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<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GL52</accession>
    <name>A0AAJ0GL52_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0T15DRAFT_488042</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717685.1">
        <property type="nucleotide sequence ID" value="XM_062866469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GL52"/>
    <dbReference type="GeneID" id="87885298"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000158">
        <property type="entry name" value="Cytochrome P450, putative (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF210">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ASQL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="418"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3301905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="489" mass="55367" checksum="6B69AC20F6E80C42" modified="2024-07-24" version="1">MVVLNMMYNLYFHPLARFPGPPLARSSLLWRLWHTMRGRSHRVIQRAHQEYGPVFRVSPNELSFASVGSWKAIYGFPGPGKDHLIKGEFYDIFGGAYKTGCVGSERNPTIHARKKKNLTAAFSVKALAAQEPIVQACLDRFVEKLGPLSEKSVGKGINVVEWLEMAAFDILGEMAFGEGFGCVEKEEHHSWMDLILKHLFEVTMVDNLRRFKVLAVLGRVLLPSLVSGVREEHSMYSRAKVQKRLDASTPRQDFFTHIVNKVRSGDVSQEEMTAHASTLIIAGGETTATALAAAVYYLLKTPGTLEKLTHEIRSRYKSYSEIDATSAQQLPYLQAVIQEALRIHPPGSQGFPRVSPGCEIDGYWVPKGTEVYTSAWTVTHDPQYFHDPMTFKPERWLDPDCADVTEASQPFSLGYRACIGRNFAFLEMASCLSKMLFRYDLKLVDNDLDWEAASRCYVMWWKAPVHVLFEERARRNDEVPPCELGELEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GL85</accession>
    <name>A0AAJ0GL85_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0T15DRAFT_505042</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3301957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717737.1">
        <property type="nucleotide sequence ID" value="XM_062867519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GL85"/>
    <dbReference type="GeneID" id="87886348"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04591">
        <property type="entry name" value="CBS_pair_voltage-gated_CLC_euk_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03684">
        <property type="entry name" value="ClC_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3080.10:FF:000011">
        <property type="entry name" value="Chloride channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.10:FF:000119">
        <property type="entry name" value="Chloride channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF6">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
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                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
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                <person name="Ament-Velasquez S.L."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 333.67</strain>
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    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Haridas S."/>
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                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
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                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
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                <person name="Chen C."/>
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                <person name="Ng V."/>
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                <person name="Ament-Velasquez S.L."/>
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                <person name="Powell A.J."/>
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                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
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                <person name="Hiltunen Thoren M."/>
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            <dbReference type="PubMed" id="37820761"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
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                <person name="Brannstrom I.O."/>
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                <person name="Cros-Aarteil S."/>
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
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                <person name="Ament-Velasquez S.L."/>
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                <person name="Barry K."/>
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                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
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        </reaction>
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    <comment type="catalytic activity">
        <reaction evidence="10">
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        </reaction>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
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    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
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    <dbReference type="GO" id="GO:0005737">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005524">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0000147">
        <property type="term" value="P:actin cortical patch assembly"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:actin filament organization"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967:SF57">
        <property type="entry name" value="AUXILIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
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        </location>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="12">
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="874"/>
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        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="12">
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        </location>
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        </location>
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        </location>
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        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="12">
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        </location>
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            <begin position="940"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3302202.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
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    <sequence length="1090" mass="116701" checksum="366F41828527BEE7" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GLR8</accession>
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        <submittedName>
            <fullName evidence="3">Microtubule associated protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">B0T15DRAFT_300211</name>
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        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Sordariomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062863805.1"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051256">
        <property type="term" value="P:mitotic spindle midzone assembly"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MAP65_Ase1_PRC1"/>
    </dbReference>
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        <property type="entry name" value="FASCETTO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN REGULATOR OF CYTOKINESIS 1 PRC1-RELATED"/>
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    </dbReference>
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    </dbReference>
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            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="226"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="401"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="480"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="505"/>
            <end position="518"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="660"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="676"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3302294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GLU0</accession>
    <name>A0AAJ0GLU0_9PEZI</name>
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        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit L</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_299745</name>
    </gene>
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        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718067.1">
        <property type="nucleotide sequence ID" value="XM_062863800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GLU0"/>
    <dbReference type="GeneID" id="87882629"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03011">
        <property type="entry name" value="eIF3l"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019382">
        <property type="entry name" value="eIF3l"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10255">
        <property type="entry name" value="Paf67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="PCI" evidence="6">
        <location>
            <begin position="254"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3302287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="473" mass="54715" checksum="5B7A60FAC39C3816" modified="2024-07-24" version="1">MSYQTGMAPARAIEDDSDVEEEALVADYKEQVQYAGDMDELDPGLLAPQAEDIQARLVQAAQPLDYQATLETKFQSYDNYCALFHYILNSEGPVDLEPPSYYWAWDVIDEFIYQFNTFCSYRARIARQANNEEEAQILRDNPNQWGCYSVLNVLYSLIQKSQITEQLAAMRRNEDPMAVAGPYGSKNLYRMLGYFSIIGLLRVHCLLGDFSLALKTLDDIELNKKAMFARVMAAHFTTYYYVGFSYMMMRRYADAIRMFSHILVYVSRTKNFQKNTQYDSITKKNDQMLALIAICVAFHPTRLDDTIHTALREKYGDQLLKLQRGGPESLPIFEELFRLACPKFISPVPPDFDRPEVNVDPVDHHLSIFMEEVKTNMWSPTIKSYLRLYTTMDLKKLAGFLDVKPEELRSMLLVTKQRTKQLRWTDNGLLEGELINISDLDYALQGDLIHISEAKMGRKLVDWYLRNLARTYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GLU8</accession>
    <name>A0AAJ0GLU8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ubiquitin carboxyl-terminal hydrolase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_514379</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718114.1">
        <property type="nucleotide sequence ID" value="XM_062868113.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87886942"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02674">
        <property type="entry name" value="Peptidase_C19R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000003">
        <property type="entry name" value="Insulin-degrading enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000005">
        <property type="entry name" value="nardilysin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000004">
        <property type="entry name" value="Putative insulin-degrading enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2230.10">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035927">
        <property type="entry name" value="DUSP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006615">
        <property type="entry name" value="Pept_C19_DUSP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050626">
        <property type="entry name" value="Peptidase_M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032632">
        <property type="entry name" value="Peptidase_M16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054734">
        <property type="entry name" value="PqqF-like_C_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF18">
        <property type="entry name" value="INSULIN-DEGRADING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06337">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16187">
        <property type="entry name" value="Peptidase_M16_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22456">
        <property type="entry name" value="PqqF-like_C_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00695">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143791">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51283">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DUSP" evidence="9">
        <location>
            <begin position="1405"/>
            <end position="1524"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="8">
        <location>
            <begin position="1765"/>
            <end position="2566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1201"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1241"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1321"/>
            <end position="1387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1611"/>
            <end position="1643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1711"/>
            <end position="1759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2051"/>
            <end position="2103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2140"/>
            <end position="2167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2249"/>
            <end position="2351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1205"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1268"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1332"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1349"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1378"/>
            <end position="1387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1611"/>
            <end position="1624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1721"/>
            <end position="1753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="2082"/>
            <end position="2091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="2143"/>
            <end position="2152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="2318"/>
            <end position="2335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3302334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="2771" mass="309260" checksum="920EA669C8B15380" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GLV6</accession>
    <name>A0AAJ0GLV6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hsp90 chaperone protein kinase-targeting subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_302693</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718141.1">
        <property type="nucleotide sequence ID" value="XM_062863833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GLV6"/>
    <dbReference type="GeneID" id="87882662"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.610:FF:000002">
        <property type="entry name" value="Hsp90 co-chaperone Cdc37, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.610">
        <property type="entry name" value="Cdc37, Hsp90 binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004918">
        <property type="entry name" value="Cdc37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013873">
        <property type="entry name" value="Cdc37_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013874">
        <property type="entry name" value="Cdc37_Hsp90-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038189">
        <property type="entry name" value="Cdc37_Hsp90-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013855">
        <property type="entry name" value="Cdc37_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12800">
        <property type="entry name" value="CDC37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12800:SF4">
        <property type="entry name" value="HSP90 CO-CHAPERONE CDC37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08564">
        <property type="entry name" value="CDC37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08565">
        <property type="entry name" value="CDC37_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03234">
        <property type="entry name" value="CDC37_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01069">
        <property type="entry name" value="CDC37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01070">
        <property type="entry name" value="CDC37_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01071">
        <property type="entry name" value="CDC37_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101391">
        <property type="entry name" value="Hsp90 co-chaperone CDC37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cdc37 N-terminal" evidence="10">
        <location>
            <begin position="16"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc37 Hsp90 binding" evidence="9">
        <location>
            <begin position="215"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc37 C-terminal" evidence="8">
        <location>
            <begin position="410"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="197"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="484"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="142"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="211"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="485"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="506"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3302361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="517" mass="57730" checksum="712EE92ED5C579A4" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GMA9</accession>
    <name>A0AAJ0GMA9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B0T15DRAFT_310672</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718371.1">
        <property type="nucleotide sequence ID" value="XM_062863922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GMA9"/>
    <dbReference type="GeneID" id="87882751"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF9">
        <property type="entry name" value="ENDOGLUCANASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042513897" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="16">
        <location>
            <begin position="20"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="17">
        <location>
            <begin position="292"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK3302591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="329" mass="32895" checksum="77599E1803896663" modified="2024-07-24" version="1">MKSLTIAALAALWAQNASAHATFQQLWVDGVDYGSQCARLPASNSPVTNVASNDVRCNVIGTRPGAKCPVKAGSTVTVEMHQQPGDRSCSSEAIGGAHYGPLMVYMTKVSDAASADGSTGWFKIFQDTWAKNPSGGSGDDDFWGVKDLNKCCGKMNVKIPADLPDGDYLLRAEVIALHTAGSPGGAQLYMTCYQLTVTGGTGTASPATVLFPGAYKASDPGIQVNIHAAMSTYVAPGPSVYAGGSTKPAGSGCTGCESTCAVGSGPSATAPKPTSSPSATSAPGGGGGSGGCAVAKYGQCGGTGYSGCTSCASGSTCSAVSPPHYSQCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GMC9</accession>
    <name>A0AAJ0GMC9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PD-(D/E)XK nuclease-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_577658</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718367.1">
        <property type="nucleotide sequence ID" value="XM_062871066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GMC9"/>
    <dbReference type="GeneID" id="87889895"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046797">
        <property type="entry name" value="PDDEXK_12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20516">
        <property type="entry name" value="PDDEXK_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PD-(D/E)XK nuclease-like" evidence="2">
        <location>
            <begin position="114"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3302587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="323" mass="36711" checksum="0604A8621C6A131B" modified="2024-07-24" version="1">MAPCPRTDSSPNPDRNQSWDNLSEVQSISTADTSGASRSGRSSPRKKEVALRRTHEWPVARVNITQLKSIPALLESLALDLKKIESMSANAGMLDQPNPDWFYTARDGQEELRAVHRQMQKICRNSLTTPSRAQNVVTFRNITLCRTLKAFHDDDPALRENKVDYGIFLQPARGDDGLAERLSDLASEDIDLTHFTLSDFAPTPLAISIKTKTLQAKPTEGSVQLANWVRAHFRQLARLVERCHHDPDYQLPVLPIIYVYGNTWRVDFAHRCDGKTMIYEGMSVGDTHTVYGCYQVCAAIRRLAAWVQEDFRRWWLETTKLPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GNI3</accession>
    <name>A0AAJ0GNI3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_268633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719033.1">
        <property type="nucleotide sequence ID" value="XM_062863436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GNI3"/>
    <dbReference type="GeneID" id="87882265"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="239"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3303253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="327" mass="33131" checksum="B43B60E73B6A308C" modified="2024-07-24" version="1">MSRVMQMPPPPPLLLTKRVTAFLRANLSAHIHSAMLTTPAGSLLAHASDLPASALRRQAAVAASLWALQGPAPGAPHTPGPAQATLPTGSTVRTSKKSGKQHSPTVTIQMDSGAVFVIRRLRCGMLFICMGGSESAAAGRQTPTPPAPHSTRLSRSPAPTAPPTPGPSSEQPPDMSAPTGQSNPPQPPTATRTHPPFIAAADAPPPPSSTIATTTPPPTAATTSASKTTSSLPVPPGAPVGSPSGASVFSAHTTHTTHTTGSSAAITVSGSSVSLMRRQVEELARWLDDRLGSLCVPEEGIGIPPNPDLGGSTTGPRGAASTEVEVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GP15</accession>
    <name>A0AAJ0GP15_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_496052</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719282.1">
        <property type="nucleotide sequence ID" value="XM_062867151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GP15"/>
    <dbReference type="GeneID" id="87885980"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF42">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="41"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="292"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="374"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="306"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="374"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3303502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="421" mass="45074" checksum="D0E9E64777453C12" modified="2024-07-24" version="1">MPSSQGLDGSPSPEYLAQSLAPTIRAVMWVSIAIPLVFVILRCYVRLVIRKVFGLDDALLVISLILLIAFGAVIEAALAKGFGRHVQWVMLEAPQDAISVALLAQVSQPLVIMSCAFGKTSIAVTLLRLAPQHCVKVVLWAVTVIMNVLHILVSILLYYRCKDPRVLWDPSVETTCWPTEVYLYVMYFIGAYSAVTDFILASIPWAVLWKLNMRKREKFGIAFAMSLGIFAGGTAIVKCTKLGANSTSTDPTYDVGTLLLWAGAENGLIIVAACVPTLRPILRAFWRSTVKSSGGEPSHPLDDISNANANNNKNRNSGFFGGGGGGGRRSKSAGGGGPGQWTVMIEAEDQNSDNNSDRSILKQHHHGADLAVVEGADSSSGASSVAGRGVRDDAESGCETTGVESPWSGRIHKTTEVTGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GPG8</accession>
    <name>A0AAJ0GPG8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cupin type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_504900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719512.1">
        <property type="nucleotide sequence ID" value="XM_062867511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GPG8"/>
    <dbReference type="GeneID" id="87886340"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02219">
        <property type="entry name" value="cupin_YjlB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047121">
        <property type="entry name" value="YjiB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36448">
        <property type="entry name" value="BLR7373 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36448:SF3">
        <property type="entry name" value="CUPIN TYPE-2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-1" evidence="2">
        <location>
            <begin position="48"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3303732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="326" mass="35529" checksum="BB4D6ED828C64F19" modified="2024-07-24" version="1">MTRSELLLNLTPLSTLQTEKHLIPPHPPSNLPNSAATNKPLLFYRQAFTFTSPTNNNNNNPSKASTAEAIEHHLRKTNIVAPQWRYGMYPTSHFHSTTHEVLCVSSGRARLLFGGEENPGRVEVVVQTGDVIVIPAGVAHRLLREEEGEEGGGFEMVGSYPVGAEQWDMCYPGEGGEEEEERVGRIKALEWFGRDPVYGETGPVLEVTRTKLSVQQCVITTTSSSSSSTSRSGRGSGSRSVLSPGSGTHAATAILTIPVVIAAVLALADGGGGSDEENGPKEEEEVEEVEEEEEVERLTDRDRWSPTALGRRNVFRKEVERQARLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GPJ5</accession>
    <name>A0AAJ0GPJ5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7735 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_496293</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719542.1">
        <property type="nucleotide sequence ID" value="XM_062867168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GPJ5"/>
    <dbReference type="GeneID" id="87885997"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056637">
        <property type="entry name" value="DUF7735"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24870">
        <property type="entry name" value="DUF7735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042558195" description="DUF7735 domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7735" evidence="3">
        <location>
            <begin position="52"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3303762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="252" mass="26421" checksum="BDB91197082F6DC2" modified="2024-07-24" version="1">MRFHICLGGLAALVAAAGISARFLADSPPATTLNPLLAARQATPTTTVSLPRRTLTPDPWQCVTENITQYFDVPKPTGNVLDAINSYAAEVNKACLVTAVGYQQRSCTMSDIKLWCGFTTAAPADVLSSYSSYASEVVSFWTAKSSMISILSTSCPVAWGRHHMADHEWQRIAGAHANCYLAAHSQTQSQSQTQTQSQTHTGTETTAPTGTVAGATTSTTPGTSKANLLGRAQTVEAMALVSAGLAVLANAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GPK0</accession>
    <name>A0AAJ0GPK0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_540501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719320.1">
        <property type="nucleotide sequence ID" value="XM_062869791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GPK0"/>
    <dbReference type="GeneID" id="87888620"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3303540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="97" mass="10957" checksum="FEDB356757A541F1" modified="2024-07-24" version="1">MADLDAANSDDSRFFWSQVSVFDFWFLQLRYVDAACIRVSSSFCMGVQVVVLGAGISVYLRMYLSIPLFFHDPGGSSKLYVREHSSIGLQSRGTYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQ03</accession>
    <name>A0AAJ0GQ03_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B0T15DRAFT_557428</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719792.1">
        <property type="nucleotide sequence ID" value="XM_062870446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQ03"/>
    <dbReference type="GeneID" id="87889275"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051735">
        <property type="entry name" value="CFEM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928:SF1">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6 15" id="KW-0349">Heme</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042603092" description="CFEM domain-containing protein" evidence="16">
        <location>
            <begin position="21"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="17">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK3304012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="272" mass="26362" checksum="5D7D248826F0D81E" modified="2024-07-24" version="1">MKISVSAVFAVVGVVAVAAAEDYPANMPACGKTCGDNMLAKAGEFNCTGTDVKPCICEKADFGYGIHDCNVQSCPDVDQANIAIGWANNMCANAGKPINIPSATAVSAAGGASGSPVATSSVVTTIISGSSTFVTTSVTTVFGSGAGSSENVSPTPITTSTWTSVFTSGSLTTTLTGETTVSGVSGVAGATSVPQTTVTSPIVSTQTSGSSTFETTVGSTTIVSSVTGDALSSELSSQASDATSTSSGQGAQVTAAPALGVLAAAGIAVALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQD7</accession>
    <name>A0AAJ0GQD7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_231885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719946.1">
        <property type="nucleotide sequence ID" value="XM_062862957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQD7"/>
    <dbReference type="GeneID" id="87881786"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3304166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="122" mass="14109" checksum="892012FD03438654" modified="2024-07-24" version="1">MSFFDRQDIPGKRRDDGAFEDDVAMLTDYCLIVADEAQDEFEMHGLVQLSMRTSLEASKQCRFVHRRLRRTPCELRGLQMPSRNCRNARDRANSLIIIVCSRMLSVLGSPTLPHPLLRLQHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQP4</accession>
    <name>A0AAJ0GQP4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alcohol dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_398858</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720168.1">
        <property type="nucleotide sequence ID" value="XM_062864976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQP4"/>
    <dbReference type="GeneID" id="87883805"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08297">
        <property type="entry name" value="CAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000002">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="9">
        <location>
            <begin position="19"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3304388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="353" mass="37502" checksum="B96B874010ECDC5A" modified="2024-07-24" version="1">MTGFDIPSEQWAQVVEKSGGPVVYKKIPVQKPGPDEVLVNVKYSGVCHTDLHAMMGDWPLATKLPLVGGHEGAGVVVAKGELVTDIEVGDYAGIKWLNGSCLACSFCMQADEPLCPHALLSGYTVDGSFQQYAIAKAAHVARIPKDVDLEAVAPVLCAGITVYKGLKESGARPGQWVAIVGAGGGLGSMAIQYAKAMGMHVIGIDGGEEKRQSCKTLGAAAYVDFMTSKDLVSEVKAATPDGLGPHAVLLLAVSEKPFQQATEYVRSRGSVICIGLPAKAFLKAPVFDTVIRMISIKGSYVGNRQDTQEALDFFQRGLVKVPFKTVGLSELQNVYDLMKAGKIVGRYVVDTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GSJ2</accession>
    <name>A0AAJ0GSJ2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_531959</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721102.1">
        <property type="nucleotide sequence ID" value="XM_062869287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GSJ2"/>
    <dbReference type="GeneID" id="87888116"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050839">
        <property type="entry name" value="Rho-assoc_Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988:SF71">
        <property type="entry name" value="CITRON RHO-INTERACTING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988">
        <property type="entry name" value="MYOTONIC DYSTROPHY S/T KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="371"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="72"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="381"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="422"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="459"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="506"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="523"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="554"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3305322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="682" mass="74933" checksum="5448D2758B6ABD0D" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GSP6</accession>
    <name>A0AAJ0GSP6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B0T15DRAFT_502358</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720995.1">
        <property type="nucleotide sequence ID" value="XM_062867430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GSP6"/>
    <dbReference type="GeneID" id="87886259"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF19">
        <property type="entry name" value="GLYCOSYLHYDROLASE FAMILY 61-8 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042574030" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="16">
        <location>
            <begin position="22"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="17">
        <location>
            <begin position="20"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK3305215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="291" mass="33361" checksum="4D69585C8E6CD1DF" modified="2024-07-24" version="1">MRLPSFLAVAWGIALPVTAHGGVFNYTIDGVDYPGESTARLPMKGQVSVQRRWWGDPIYNISHPYLACNRGYPLQVQPPKEHAPIKAGGVIQAFYAPPPCPPNWSRPDEPLFPEWNDPKPMVCLTPRSPWYHYWGPLMVYMADCGGPCDKWDGRGQRWFKIWESGYSSTSWPAGSISRASITDRRTWEQNDLWQKPITVRVPEKLKPGHYLIRHEVFFSEGSNGFPQLFPQCAQLEVSGQGTAVPSQEYLVSFLGVYKESDPAFKYLGDAYYERRRQTYEYTVPRPKVWRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GSX9</accession>
    <name>A0AAJ0GSX9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ubiquitin thioesterase OTU</fullName>
            <ecNumber evidence="9">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0T15DRAFT_485152</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="9"/>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721338.1">
        <property type="nucleotide sequence ID" value="XM_062866278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GSX9"/>
    <dbReference type="GeneID" id="87885107"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22745">
        <property type="entry name" value="OTU_OTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048857">
        <property type="entry name" value="OTU1_Ubl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057766">
        <property type="entry name" value="Znf-C2H2_OTU1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13312">
        <property type="entry name" value="HIV-INDUCED PROTEIN-7-LIKE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13312:SF0">
        <property type="entry name" value="UBIQUITIN THIOESTERASE OTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21403">
        <property type="entry name" value="OTU1_UBXL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24560">
        <property type="entry name" value="zf-C2H2_OTU1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5 9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="OTU1 Ubl" evidence="12">
        <location>
            <begin position="7"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="OTU" evidence="11">
        <location>
            <begin position="131"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="OTU1-like C-terminal C2H2-type zinc finger" evidence="13">
        <location>
            <begin position="267"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF21403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF24560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3305558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="304" mass="34059" checksum="EA349BF449D504E3" modified="2024-07-24" version="1">MLIQISLRAPNGQSRIQIDDDSPLSALVELIKTKTELANFSLKYGYPLKSLDISPALQGTPVKELNLRGETIVVASVDPSPPTPALQPASAEPKPKPFTPKGIEPDETSLQWEERGGYMAVGGAIGLDNPSRTLRNQVADYILNHPNEYNQAILGEDPQRYTTKMRRMDTWGGAIELSILSDIYNLEISSIDVKSLRVDRFGEGKSTRVIILYSGIHYDRIAFCMDLSYPVEVDVTKWSTDDEEVLEKARQLAQQLQRLHYYTDTTDFVIKCQVCNWIGQGTRDAAKHETETGHNQFGEMQITD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GT20</accession>
    <name>A0AAJ0GT20_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_202581</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721357.1">
        <property type="nucleotide sequence ID" value="XM_062862589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GT20"/>
    <dbReference type="GeneID" id="87881418"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3305577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="114" mass="12351" checksum="56D4FE7274C00847" modified="2024-07-24" version="1">MGCCGLFKKHKKNKVHDQGFAVRPVQQTVNGGNVSYHPSSQQYQYGGSGGRYQYQDPNHAARLAANRALAQGAAMGINGATHGKYSKYVGKGANMAADQFTKYQEKQGRCSPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GT36</accession>
    <name>A0AAJ0GT36_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_511542</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
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                <person name="Barry K."/>
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                <person name="Grigoriev I.V."/>
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                <person name="Johannesson H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="11">CBS 333.67</strain>
        </source>
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        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="ABC_TM1F"/>
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    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
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            <end position="380"/>
        </location>
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            <end position="1483"/>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
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                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
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            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="1">CBS 333.67</strain>
        </source>
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        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
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                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
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        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
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</entry>
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    <accession>A0AAJ0GTG1</accession>
    <name>A0AAJ0GTG1_9PEZI</name>
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            <fullName evidence="11">glutaryl-CoA dehydrogenase (ETF)</fullName>
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    </protein>
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    </gene>
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        <name type="scientific">Chaetomium strumarium</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>glutaryl-CoA + oxidized [electron-transfer flavoprotein] + 2 H(+) = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13389"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:57378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.3.8.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid metabolism; lysine degradation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Amino-acid metabolism; tryptophan metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.6" evidence="11"/>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721628.1">
        <property type="nucleotide sequence ID" value="XM_062869372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GTG1"/>
    <dbReference type="GeneID" id="87888201"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004361">
        <property type="term" value="F:glutaryl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046949">
        <property type="term" value="P:fatty-acyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01151">
        <property type="entry name" value="GCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000003">
        <property type="entry name" value="glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000006">
        <property type="entry name" value="Glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000008">
        <property type="entry name" value="Glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052033">
        <property type="entry name" value="Glutaryl-CoA_DH_mitochondrial"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42807">
        <property type="entry name" value="GLUTARYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42807:SF1">
        <property type="entry name" value="GLUTARYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0274">FAD</keyword>
    <keyword evidence="4 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="16">
        <location>
            <begin position="48"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="15">
        <location>
            <begin position="163"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="14">
        <location>
            <begin position="280"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK3305848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="428" mass="46996" checksum="0B4BBC6112E543D9" modified="2024-07-24" version="1">MSRVLFKRFPQRVLLRAQFTHGARSYASTSPASQFDWQDPLGSKNLLTEEELAISETAERYCQGHLLPRVLQAYRDEHYDPKILEEMGELGLLGATINGYGCAGVSTVAGALITRAVERVDSGYRSSMSVQSSLAMGAIHDFGSPEQKEKYLPEMAKGKIIGAFGLTEPNHGSDPGSMEAVAREHPQKKGYYLLKGSKTWITNSPIANVLVVWAKLQETGKIRGFLVDRKECPPGTLETPAIKNKTGLRASITGMIHLEDCPVPTENMFPEIEGLKGPFACLNSARYGIALGVMGALEDCIDRARTYALERKQFKGNPLAKYQLVQKKLADAATDAAYGTLAAIQVGRLKDERKATPEMISMIKRQNCDRALHNARVLQEIFGGNAVSDEYMVGRHVANLYVTQTYEGQSDIHSLILGRAITGIQAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GTH4</accession>
    <name>A0AAJ0GTH4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_211740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721621.1">
        <property type="nucleotide sequence ID" value="XM_062862685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GTH4"/>
    <dbReference type="GeneID" id="87881514"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="60"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="120"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3305841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="276" mass="31649" checksum="7A97064B3C02F56F" modified="2024-07-24" version="1">MPELADELSFQEVRAQFNEFNNPRYKQPRMTCHWCRKETNSNITRLRAHLKDCVRFQETQEPRQFSPSMLPPPLPPQPTLSQREPRFVPDWGTSLYNKGRGDPEGGPPRSDRELELIAEVQAKDQRIAALELERKKLKELLADYRRREGDRSLVAPEVAHRRAAVAGPPNGTTAAFGQRSASFPDPPIFYNDKDRDTVTFEMWFRQTTSKLKYNADHYPDDGAKQAYIESRLGPKAFELVAPFLRETHEEPVTSSRELLDLLSSCFASYPDLPSDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GTL4</accession>
    <name>A0AAJ0GTL4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPI anchored serine-threonine rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_213295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721654.1">
        <property type="nucleotide sequence ID" value="XM_062862698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GTL4"/>
    <dbReference type="GeneID" id="87881527"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042558196" description="GPI anchored serine-threonine rich protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="325"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3305874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="460" mass="45903" checksum="59DA0BD3E4471E17" modified="2024-07-24" version="1">MRGFLFLGVLPSIALAGRASRPFFLRRTDNYDAQTCEELGLQQCGTGCIPLDYSCCPDQTGGCPAEKHCVVGDDGQAGCCQNGFTCSGNGGVTETTFVTPTTTLSTLSSTDVLGPTVTLTSSTVDINTSSSSEASPSSTTDQPGSIAATDEVPSSTSTEGLQSSTITETMDSSSATASVSSTEFASTTESTGSTETASSRESSSSSEVSSSTSLSDTATTSRSTSSASASETVSPTTSASNTTTTTTSSASQTAITSTRSPSYTTSTIYTTTTKTITSCAIPTDSTHSHAPCPASSSSAILVVTETVAVSTTICPVTTATATTTITTSSSNSPSHTNPTTTALSAQQQTPNSTTVMQPVSKPDVICPGRGQGCYPATAATRHAGVAPSSVAKGSTVPTAAAAAAGAANYTGEYHPTHPAASSTTSNSKGVVTAGAANPGLDVGMGMGMVVFGLALIQGMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GU35</accession>
    <name>A0AAJ0GU35_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_219257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3306158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721938.1">
        <property type="nucleotide sequence ID" value="XM_062862793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GU35"/>
    <dbReference type="GeneID" id="87881622"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3306158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="215" mass="24009" checksum="C9C73A2C96C56CC9" modified="2024-07-24" version="1">MISPNTLYITLQYLQGANNNVEFHWGLYITDRSAPNGHFLSVIDANPPIMDLRMELREIENPTKAPRMVVCLKIATSPGLTALHSAASAVRLMENEHLPDGEHQWNSRVWVKEVLSALAKRGYIQMPWGLEQVEQNCLYTAKENIQSAGRPVVYNELAWLTRKVDGALNGPGPLVPKPRSRVELPTESPYAEAPAENSRPRAELPTGRSHEELPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GU53</accession>
    <name>A0AAJ0GU53_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_398393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3306247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722027.1">
        <property type="nucleotide sequence ID" value="XM_062864953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GU53"/>
    <dbReference type="GeneID" id="87883782"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF12">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="188"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3306247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="674" mass="76124" checksum="F6D061DB66A4CA47" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GUS1</accession>
    <name>A0AAJ0GUS1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_557081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3306225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722005.1">
        <property type="nucleotide sequence ID" value="XM_062870434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GUS1"/>
    <dbReference type="GeneID" id="87889263"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="46"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3306225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="765" mass="85105" checksum="73B36BF1B5A8E57B" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GUT1</accession>
    <name>A0AAJ0GUT1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_527493</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722313.1">
        <property type="nucleotide sequence ID" value="XM_062868976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GUT1"/>
    <dbReference type="GeneID" id="87887805"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14135">
        <property type="entry name" value="STKc_PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000078">
        <property type="entry name" value="Serine/threonine-protein kinase PRP4 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044092">
        <property type="entry name" value="STKc_PRP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF103">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PRP4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="474"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="347"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="428"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="68"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="120"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="244"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="265"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="292"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="366"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="399"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="503"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3306533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="818" mass="91141" checksum="7D3A9B27692DD4A0" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GVF1</accession>
    <name>A0AAJ0GVF1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Histone-fold-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_484105</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Protein transport. Probably involved in vesicular traffic.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722871.1">
        <property type="nucleotide sequence ID" value="XM_062864688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GVT7"/>
    <dbReference type="GeneID" id="87883517"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01867">
        <property type="entry name" value="Rab8_Rab10_Rab13_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000363">
        <property type="entry name" value="Secretion related GTPase srgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3307091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="206" mass="22771" checksum="BB146A0C1AE4B1B1" modified="2024-07-24" version="1">MSSNNRNYDFLIKLLLIGDSGVGKSCCLLRFSEDSFTPSFITTIGIDFKIRTIELDGKRVKLQIWDTAGQERFRTITTAYYRGAMGILLVYDVTDERSFNNIRTWFANVEQHATEGVNKILIGNKCDWEEKRVVSTERGQQLADELGIPFLEVSAKTNTNIDKAFYSLAADIKKRIIDTSKPEQAGAGPAVNVAEQGGAGAGGKCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GVV2</accession>
    <name>A0AAJ0GVV2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0T15DRAFT_413966</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="4"/>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722866.1">
        <property type="nucleotide sequence ID" value="XM_062865433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GVV2"/>
    <dbReference type="GeneID" id="87884262"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045025">
        <property type="term" value="C:mitochondrial degradosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000965">
        <property type="term" value="P:mitochondrial RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17913">
        <property type="entry name" value="DEXQc_Suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18805">
        <property type="entry name" value="SF2_C_suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000269">
        <property type="entry name" value="ATP-dependent RNA helicase SUPV3L1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000957">
        <property type="entry name" value="ATP-dependent RNA helicase SUV3L, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055206">
        <property type="entry name" value="DEXQc_SUV3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022192">
        <property type="entry name" value="SUV3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041082">
        <property type="entry name" value="Suv3_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044774">
        <property type="entry name" value="Suv3_DEXQc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22527">
        <property type="entry name" value="DEXQc_Suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12513">
        <property type="entry name" value="SUV3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18147">
        <property type="entry name" value="Suv3_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="355"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3307086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="736" mass="84605" checksum="47FB840780104959" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GWC2</accession>
    <name>A0AAJ0GWC2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HTH APSES-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_393581</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723067.1">
        <property type="nucleotide sequence ID" value="XM_062864692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GWC2"/>
    <dbReference type="GeneID" id="87883521"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990862">
        <property type="term" value="C:nuclear membrane complex Bqt3-Bqt4"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070197">
        <property type="term" value="P:meiotic attachment of telomere to nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044820">
        <property type="term" value="P:mitotic telomere tethering at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.260.10:FF:000002">
        <property type="entry name" value="APSES transcription factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037548">
        <property type="entry name" value="Bqt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018004">
        <property type="entry name" value="KilA/APSES_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38044">
        <property type="entry name" value="BOUQUET FORMATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38044:SF1">
        <property type="entry name" value="BOUQUET FORMATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01252">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0183">Conidiation</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0749">Sporulation</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="HTH APSES-type" evidence="7">
        <location>
            <begin position="61"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="163"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="362"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="195"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="227"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="244"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="378"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3307287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="443" mass="47771" checksum="99F9D2FC413B1D19" modified="2024-07-24" version="1">MAPNRHLPERRNPLLIDDVPSHSELVGRRRLGQTQLTARMVAAIPGSEVDTSSLGAFDYAHLRAPLPKGIVSGIFKSSPQSYFLMRRSQDGFVSATGMFKATFPWAAQEEEETERKYIKSLPTTSPEETAGNVWIPPEQALALAEEYGIAPWIRALLDPTDIPLQPSTDSGPPKHITPPPKFFSGQPTLAPPTPASTRASRSRRSVSPAKSMASKRATASPRKRRVASVQSSSVVTETQSTSTGDSVSPTLVNGETPFQSQLSAPSTSKRTAVEEATETELRIESIEKEPAVVLEPVEEEPKLKVHVDQDVTVDADGEEVKRTKVDLEVPILGELPSPQDAAKMVADARAMVEAAVKADNESTAAVAGSKGKRKADEIAQDEEGEEGEDAAVEPPRAKKVKTEAEIRKEKIRKRAFFGLTATVAVGAFGALLPVITPYVMNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GWJ5</accession>
    <name>A0AAJ0GWJ5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_530283</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723246.1">
        <property type="nucleotide sequence ID" value="XM_062869162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GWJ5"/>
    <dbReference type="GeneID" id="87887991"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042171">
        <property type="term" value="F:lysophosphatidic acid acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035965">
        <property type="term" value="P:cardiolipin acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886:SF29">
        <property type="entry name" value="PUMMELIG, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886">
        <property type="entry name" value="RE40534P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="163"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3307466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="534" mass="59839" checksum="C967BCA703B62A31" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GX97</accession>
    <name>A0AAJ0GX97_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucanase</fullName>
            <ecNumber evidence="9">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_391504</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="9">Belongs to the glycosyl hydrolase family 6.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3307824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723604.1">
        <property type="nucleotide sequence ID" value="XM_062864594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GX97"/>
    <dbReference type="GeneID" id="87883423"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.40">
        <property type="entry name" value="1, 4-beta cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016288">
        <property type="entry name" value="Beta_cellobiohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036434">
        <property type="entry name" value="Beta_cellobiohydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001524">
        <property type="entry name" value="Glyco_hydro_6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34876">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34876:SF10">
        <property type="entry name" value="GLUCANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01341">
        <property type="entry name" value="Glyco_hydro_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001100">
        <property type="entry name" value="Beta_cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00733">
        <property type="entry name" value="GLHYDRLASE6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51989">
        <property type="entry name" value="Glycosyl hydrolases family 6, cellulases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00656">
        <property type="entry name" value="GLYCOSYL_HYDROL_F6_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="4 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042314276" description="Glucanase" evidence="9">
        <location>
            <begin position="19"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6 8">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="349"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001100-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001100-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3307824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="383" mass="41620" checksum="EF7C3BF6FAA86E98" modified="2024-07-24" version="1">MRASSLLAALATGGLVSAAPSIKEPRATSAGGDVNPFQGKAQFVNPKWAAKLDQTFKSFLWKGDIANSLKVRKIQQTMGSFVWVSRIADLSNIDDAIVAARKAQKKTGKKQIVGLVLYNLPDRDCSAGESAGELHSDENGLERYKNEFIKPHAEKVAAAKDLSFAIVLEPDSLANLVTNMGVELCAKAAPTYREGIAHAIASLQYDHVHLYMDAAHGGWLGWDDNLPLAAKEFAEVVKLAGEGKKVRGFVTNVSNYNPFNAVVRENYTEWSNSWDESHYATSLAPHLQENGLPAHFIVDQGRVALPGARKEWGEWCNVFPAGFGPAPTTSTNNTVVDALVWVKPGGESDGQCGLTGAPRAGEWFDEYAQMLVKNADPSVYKWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GXS0</accession>
    <name>A0AAJ0GXS0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SGF29 tudor-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_482739</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3307815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723595.1">
        <property type="nucleotide sequence ID" value="XM_062866122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GXS0"/>
    <dbReference type="GeneID" id="87884951"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20393">
        <property type="entry name" value="Tudor_SGF29_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037802">
        <property type="entry name" value="SGF29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010750">
        <property type="entry name" value="SGF29_tudor-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047288">
        <property type="entry name" value="Tudor_SGF29_rpt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21539">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21539:SF0">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07039">
        <property type="entry name" value="SGF29_Tudor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51518">
        <property type="entry name" value="SGF29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGF29 C-terminal" evidence="2">
        <location>
            <begin position="234"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3307815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="370" mass="39885" checksum="595A1ACC8F52CDCA" modified="2024-07-24" version="1">MSSRNRNSRGPNRNSGTTQGEEAHLWGQIRDDIRSMVDGVNSSNDSLRAIVAQDSYIAKNKDDIDIGAEEQKLDNLLRSGVKGADTSKQQIDALIEHVTVLRALVKAREDSEAQTAGPSGLSGRERPSGLLAASSRSASARAASSAREKERERDSQRDRDRDPGSVYEFDGSGDSPVPSPVGRKLGGSGGAGSDRSVNRDSVPPRGGDRDTPGKADSVPPESGAIGTATAAQRAKITFFKGQDVVFKPKPATTTESTEWMLGRVQQVLGEGKSRRYKVQDADPDLPPDQRVEYRTSASSMIPIPAPGVELPELQPGKTVLALYPDSTMFYKAEVIGTDAATGKTSLRFEGEENNVTLQLVDRRFVVEYRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GXS4</accession>
    <name>A0AAJ0GXS4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_530898</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723470.1">
        <property type="nucleotide sequence ID" value="XM_062869200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GXS4"/>
    <dbReference type="GeneID" id="87888029"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF2">
        <property type="entry name" value="SRPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="22"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3307690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="384" mass="41606" checksum="F0D771CE976D9883" modified="2024-07-24" version="1">MAGQNVEAWTLLSFVLAIIGLRTFVRLRSVGFRGLQLDDYLMPVAGILAIVDLVAAIYVVSAAHGLTNSYMTEEQRAALDPDSEEYAHRVLGSKIQVFGWTFYAASLWCIKGCVAVFYSRLTTKLAHWQIYVYIAYAFIGGTWVITTCILLFGCQPMSKYWQIYPDPGICQPTNSKLYVLSVLIPDVLTDMYLLSIPLPLLWAINISLRKKLSLTLLFSGVLFVIMAAIIRAVVILTAGPDGAVSGSEWAIREQFVSIVVSNLPILHAPIRSFCKKIGLGALFSTHNTTNTPYEGRTIGGGGGSYPLRSTKATNRSNPIRTATAWDSDEQILCENGSAADPSKNITVAREIAIESEAGSLKEPAGWTAAVASGGNAQGKSRGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GY59</accession>
    <name>A0AAJ0GY59_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PapD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_88849</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3307900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723680.1">
        <property type="nucleotide sequence ID" value="XM_062871424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GY59"/>
    <dbReference type="GeneID" id="87890253"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160219">
        <property type="term" value="C:cortical endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140506">
        <property type="term" value="F:endoplasmic reticulum-autophagosome adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160214">
        <property type="term" value="F:endoplasmic reticulum-plasma membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033149">
        <property type="term" value="F:FFAT motif binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090158">
        <property type="term" value="P:endoplasmic reticulum membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051685">
        <property type="term" value="P:maintenance of ER location"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902647">
        <property type="term" value="P:negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007009">
        <property type="term" value="P:plasma membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000813">
        <property type="entry name" value="Vesicle-associated protein 1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000535">
        <property type="entry name" value="MSP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016763">
        <property type="entry name" value="VAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10809:SF6">
        <property type="entry name" value="AT11025P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10809">
        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00635">
        <property type="entry name" value="Motile_Sperm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019693">
        <property type="entry name" value="VAMP-associated"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50202">
        <property type="entry name" value="MSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="MSP" evidence="8">
        <location>
            <begin position="2"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="140"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="231"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="242"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3307900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="288" mass="31136" checksum="22B5C955DD346BCF" modified="2024-07-24" version="1">MSVEIDPLELGFRRPFTVEVAQVLRIKNPNTAPVAFKVKTTAPKQYCVRPNSGRINPGYEVEVSVLLQAMKQEPPLDAKCRDKFLVQSVLIAADKEFTNVSEIWDSVDKSEIQEKKIRVAWLPPSQGSGVATPVRRQAANGFDATPDTAPPAYSSPQEDTTVADDTAPVSQSESKDVKQEPETAPATQTNAFSTPAAVAATIKSAATETYDELKDKLAKAEATIASLKNEATSGLRQRKTTSETAEQSGATQQLAQAERPQPQATEGVPVQIVAILCLASFLLAYFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GYD0</accession>
    <name>A0AAJ0GYD0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Chitin synthase</fullName>
            <ecNumber evidence="2 10">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0T15DRAFT_508523</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the chitin synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2 10"/>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723785.1">
        <property type="nucleotide sequence ID" value="XM_062867726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GYD0"/>
    <dbReference type="GeneID" id="87886555"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF9">
        <property type="entry name" value="CHITIN SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="527"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="558"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="595"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="633"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="680"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="809"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="852"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="12">
        <location>
            <begin position="143"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="70"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="747"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3308005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="885" mass="100513" checksum="722A8A71583B9AA4" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GYJ9</accession>
    <name>A0AAJ0GYJ9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bys1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_491110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724313.1">
        <property type="nucleotide sequence ID" value="XM_062866748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GYJ9"/>
    <dbReference type="GeneID" id="87885577"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006771">
        <property type="entry name" value="CetA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36195:SF4">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G01990)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36195">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G01990)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04681">
        <property type="entry name" value="Bys1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042606809" description="Bys1 family protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3308533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="154" mass="16082" checksum="AD2F54067AAA3BA8" modified="2024-07-24" version="1">MFAKLTVLALAAAAPLTSALGMARVVNKCPDTVHVWSVGSSVTGPYALGTNGGFYAEEFRKDPVTGGKALKVTKNADGLYTGAPQTIFAYNLDGDKIWYDLSDVFGDAFVGKKLVVASQESTCPSIIWPNGVPPAGSQVKTCTASKDVVFTLCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GYQ3</accession>
    <name>A0AAJ0GYQ3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_491192</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724401.1">
        <property type="nucleotide sequence ID" value="XM_062866755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GYQ3"/>
    <dbReference type="GeneID" id="87885584"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3308621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="133" mass="14387" checksum="E5635555B877B97D" modified="2024-07-24" version="1">MTLTARLIPRLFLSTSRLGRLRHNLPSASLPPFRQATSQRGIYYTSAPLPPINNSSNNNNNNNTYNNPVPIVQRNPRIIVGVTGATGTIFAAQATLKYEMDGSNSITPVQLASFATCHYAIRDLSAPPASGSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GYT0</accession>
    <name>A0AAJ0GYT0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0T15DRAFT_114851</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724443.1">
        <property type="nucleotide sequence ID" value="XM_062861542.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87880371"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15480">
        <property type="entry name" value="fMyo2p_CBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01380">
        <property type="entry name" value="MYSc_Myo5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002710">
        <property type="entry name" value="Dilute_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046943">
        <property type="entry name" value="Fungal_Myo2/2A_CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036103">
        <property type="entry name" value="MYSc_Myo5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004009">
        <property type="entry name" value="SH3_Myosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF706">
        <property type="entry name" value="DILUTE CLASS UNCONVENTIONAL MYOSIN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01843">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM01132">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50084">
        <property type="entry name" value="Myosin S1 fragment, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51126">
        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51844">
        <property type="entry name" value="SH3_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6 9" id="KW-0518">Myosin</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Myosin N-terminal SH3-like" evidence="13">
        <location>
            <begin position="6"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="12">
        <location>
            <begin position="74"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="domain" description="Dilute" evidence="11">
        <location>
            <begin position="1229"/>
            <end position="1498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="9">
        <location>
            <begin position="657"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1033"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1563"/>
            <end position="1604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1047"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="168"/>
            <end position="175"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3308663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1604" mass="182163" checksum="C7AA9CC2F8DBA8E0" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GZ08</accession>
    <name>A0AAJ0GZ08_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oxidoreductase, molybdopterin-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_524545</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062868776.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87887605"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="SO_family_Moco_dimer"/>
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    </dbReference>
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        <property type="entry name" value="Molybdopterin binding oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="sulfite oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="entry name" value="Oxidoreductase, molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005066">
        <property type="entry name" value="MoCF_OxRdtse_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008335">
        <property type="entry name" value="Mopterin_OxRdtase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372:SF6">
        <property type="entry name" value="SULFITE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372">
        <property type="entry name" value="SULFITE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03404">
        <property type="entry name" value="Mo-co_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EUMOPTERIN"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <source>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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            <dbReference type="Pfam" id="PF03404"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3308490.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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        </submittedName>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
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                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725212.1">
        <property type="nucleotide sequence ID" value="XM_062868197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H0C7"/>
    <dbReference type="GeneID" id="87887026"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054416">
        <property type="entry name" value="GST_UstS-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22041">
        <property type="entry name" value="GST_C_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="20"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Glutathione S-transferase UstS-like C-terminal" evidence="2">
        <location>
            <begin position="109"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3309432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="28270" checksum="E3449058B698EA9B" modified="2024-07-24" version="1">MASEQIVFFDLRSKEPNSCWSLNPWKTRLLLNYKGLDYRTEWLEYPELKGRFEKHVPAQEGSMPYTIPTILLPSSGEYVMDSKKIAQRLESLHPSPPLHLDAPVLAKLEEILSQRFFPPLRPILLDRVPKRILSDASIPYWVRTRSAMVGKPLDEFCAEHTHEECFAKAEPAIREVTALLVENEAGPFFLGEEVSYVDFVWAGNLYFWQRNGEDVFEELLRRSGNAEAHRKLLEGVAPWAKRDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H0R9</accession>
    <name>A0AAJ0H0R9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Proline dehydrogenase</fullName>
            <ecNumber evidence="2 5">1.5.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_481080</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Converts proline to delta-1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.5.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the proline oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.2" evidence="2 5"/>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725120.1">
        <property type="nucleotide sequence ID" value="XM_062866001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H0R9"/>
    <dbReference type="GeneID" id="87884830"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.220:FF:000013">
        <property type="entry name" value="Proline dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015659">
        <property type="entry name" value="Proline_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914:SF30">
        <property type="entry name" value="PROLINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914">
        <property type="entry name" value="PROLINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 5" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proline dehydrogenase" evidence="6">
        <location>
            <begin position="79"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3309340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="420" mass="45810" checksum="EA89C02110BF6393" modified="2024-07-24" version="1">MVQPAPLAVLPLSNVLRSLMTTTVSSSPILLSPSLAIMSVLANTTNPVLNPDRNPFLHFLLKKTFYAQFCAGENAPQVRQTIQSLKKIGFGGVILGYAREVVLTEAQTKDLSSCSTGAAAEDCVRNEINPWADGTLETVLLASPGDFVALKFTGAGRQALHALSQRLPPSEALASAIDTICKMAVARGVRLLFDAEQQALQPGIDDWTLEYMRKYNTPDRAVVYGTYQAYLKATPATVSRHLAAAREGGFALGVKLVRGAYLGSDPRHLIHDTKADTDAAYDGIAAALLRRQWNEQLKPQSEADGKTFPNVNVVLASHNRESVFKAREILSSEGKTDTDVVFAQLQGMADEVSCELVASNGADPKPRVYKYLVWGSTGECMKYLLRRAQENRDAVQRTRAGRDAMRAELIRRVKSLFGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H0X1</accession>
    <name>A0AAJ0H0X1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_387944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725581.1">
        <property type="nucleotide sequence ID" value="XM_062864414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H0X1"/>
    <dbReference type="GeneID" id="87883243"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3309801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="218" mass="25269" checksum="3D607547AF8F8B38" modified="2024-07-24" version="1">MGVPVVLATMAACGSIVTSIKSSWELRRMVKRKQEAKECDEEAPYVFRRLRRAYHDGLMSVIEYEQWYEKFLVAKVEKDLSAMRRIRAHLRILENGAPVADGQRSKRIEGGRRRHSVSFASNPTYVDYQPSRPSLEYRPDRHAHVGARPEQFVRLERQATYSRGSSSDASSRARSRSTSVRQEPRGRPARRYDSSDSSSDSSDYYYEKRHIRGRSLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H1K8</accession>
    <name>A0AAJ0H1K8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Glucose-6-phosphate 1-dehydrogenase</fullName>
            <ecNumber evidence="3 11">1.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0T15DRAFT_481611</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15841"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="1.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glucose-6-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="3 11"/>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725927.1">
        <property type="nucleotide sequence ID" value="XM_062866039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H1K8"/>
    <dbReference type="GeneID" id="87884868"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009051">
        <property type="term" value="P:pentose-phosphate shunt, oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000015">
        <property type="entry name" value="Glucose-6-phosphate 1-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000111">
        <property type="entry name" value="Glucose-6-phosphate 1-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00966">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019796">
        <property type="entry name" value="G6P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022674">
        <property type="entry name" value="G6P_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00871">
        <property type="entry name" value="zwf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429:SF0">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00479">
        <property type="entry name" value="G6PD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000110">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00079">
        <property type="entry name" value="G6PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00069">
        <property type="entry name" value="G6P_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 11" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="6 11" id="KW-0521">NADP</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase NAD-binding" evidence="12">
        <location>
            <begin position="21"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase C-terminal" evidence="13">
        <location>
            <begin position="200"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3310147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="508" mass="58204" checksum="13C99B8BD8608AA7" modified="2024-07-24" version="1">MASDMHSAGAAVELKDNTVIVVLGASGDLAKKKTFPALFGLYRNQFLPKDIRVVGYARTKMDRDEYIKRVRSYIKTPTKDIEQQLDEFCNICTYVSGQYDKDESFLQLNKHLEELEQGRKETHRLFYMALPPSVFTIVSQHLKKCCYPTNGIARVIVEKPFGKDLASSRELQKSLEPDWKEDEIYRIDHYLGKEMVKNILILRFGNSFLGATWNRHHIDNVQITFKEPFGTEGRGGYFDEFGIIRDVMQNHLLQVLTLLAMERPISFSAEDIRDEKVRVLRAIPAIEPKNVIIGQYGKSLDGSKPSYKEDDTVPKDSRCPTFCALVAYIKNERWDGVPFIMKAGKALNEQKTEIRVQFKDVTSGIFKDIPRNELVMRIQPNESVYIKMNSKLPGLTMQTVVTELDLTYRRRFSDLKIPEAYESLILDCIKGDHSNFVRDDELDASWRIFTPLLHYLDDNKEIIPMEYPYGSRGPAVLDDFTSSYGYKFSDAAGYQWPTTSAAGPGNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H287</accession>
    <name>A0AAJ0H287_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GIT Spa2 homology (SHD) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_38418</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726226.1">
        <property type="nucleotide sequence ID" value="XM_062864268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H287"/>
    <dbReference type="GeneID" id="87883097"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005826">
        <property type="term" value="C:actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902716">
        <property type="term" value="C:cell cortex of growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005078">
        <property type="term" value="F:MAP-kinase scaffold activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022018">
        <property type="entry name" value="GIT1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013724">
        <property type="entry name" value="GIT_SHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039892">
        <property type="entry name" value="Spa2/Sph1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056439">
        <property type="entry name" value="VBS_C3G9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21601:SF0">
        <property type="entry name" value="PROTEIN SPA2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21601">
        <property type="entry name" value="SPA2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12205">
        <property type="entry name" value="GIT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08518">
        <property type="entry name" value="GIT_SHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23742">
        <property type="entry name" value="VBS_C3G9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00555">
        <property type="entry name" value="GIT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="GIT Spa2 homology (SHD)" evidence="3">
        <location>
            <begin position="133"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="GIT Spa2 homology (SHD)" evidence="3">
        <location>
            <begin position="192"/>
            <end position="222"/>
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                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726758.1">
        <property type="nucleotide sequence ID" value="XM_062871089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H350"/>
    <dbReference type="GeneID" id="87889918"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032185">
        <property type="term" value="P:septin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36414">
        <property type="entry name" value="PROTEIN SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36414:SF1">
        <property type="entry name" value="PROTEIN SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3310978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="248" mass="26875" checksum="7ABA0FD8AC582CC5" modified="2024-07-24" version="1">MARTARLAAPALLLLAASLVLLWFIILSGITRTSPLRQTYFLRADTSGIPGARSISQWTYFRVCGAGNLDCGPSRPALPLGDAWASGAGGVPAPLIGRYGNGTTSFHYWYMWRFGWVFFLLALLFEVLAFGAGLLALCSRLGSVLAGLIALAGLVFLTVAVSLMTATFVGMRNVFADAGRAASLGRYAFGFAWGSWAALLISAILFFLARHKREPAIAATSTGRTRRSWWPWRRSATRRSSRVKGDYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H3A5</accession>
    <name>A0AAJ0H3A5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nucleolar protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0T15DRAFT_489383</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726505.1">
        <property type="nucleotide sequence ID" value="XM_062866593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H3A5"/>
    <dbReference type="GeneID" id="87885422"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009383">
        <property type="term" value="F:rRNA (cytosine-C5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1170:FF:000001">
        <property type="entry name" value="Ribosomal RNA methyltransferase Nop2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1170">
        <property type="entry name" value="Sun protein, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011023">
        <property type="entry name" value="Nop2p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023273">
        <property type="entry name" value="RCMT_NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054728">
        <property type="entry name" value="RsmB-like_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018314">
        <property type="entry name" value="RsmB/NOL1/NOP2-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00446">
        <property type="entry name" value="nop2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807:SF30">
        <property type="entry name" value="28S RRNA (CYTOSINE(4447)-C(5))-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22458">
        <property type="entry name" value="RsmF-B_ferredox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02012">
        <property type="entry name" value="RCMTNOP2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01153">
        <property type="entry name" value="NOL1_NOP2_SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="12">
        <location>
            <begin position="303"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="596"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="631"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="665"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="520"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="395"/>
            <end position="401"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="419"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00082314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3310725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="721" mass="79688" checksum="DA70D5F312B1AEDD" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H3B4</accession>
    <name>A0AAJ0H3B4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_520285</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726842.1">
        <property type="nucleotide sequence ID" value="XM_062868489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H3B4"/>
    <dbReference type="GeneID" id="87887318"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013694">
        <property type="entry name" value="VIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45737">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45737:SF6">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08487">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13768">
        <property type="entry name" value="VWA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00609">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51468">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VIT" evidence="3">
        <location>
            <begin position="8"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="287"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3311062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="888" mass="97873" checksum="33CC75DABCE23079" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H3N7</accession>
    <name>A0AAJ0H3N7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor IIF subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">TFIIF medium subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">TFIIF-beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0T15DRAFT_520564</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIF beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726922.1">
        <property type="nucleotide sequence ID" value="XM_062868512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H3N7"/>
    <dbReference type="GeneID" id="87887341"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005674">
        <property type="term" value="C:transcription factor TFIIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07980">
        <property type="entry name" value="TFIIF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000035">
        <property type="entry name" value="General transcription factor IIF subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003196">
        <property type="entry name" value="TFIIF_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040450">
        <property type="entry name" value="TFIIF_beta_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040504">
        <property type="entry name" value="TFIIF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011039">
        <property type="entry name" value="TFIIF_interaction"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02270">
        <property type="entry name" value="TFIIF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17683">
        <property type="entry name" value="TFIIF_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50916">
        <property type="entry name" value="Rap30/74 interaction domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIF beta subunit N-terminal" evidence="12">
        <location>
            <begin position="42"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIF beta subunit HTH" evidence="11">
        <location>
            <begin position="250"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="317"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="334"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00081473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3311142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="349" mass="40149" checksum="5E3FF9D248B5E614" modified="2024-07-24" version="1">MAEQPQIKPDPDAGSPFMDEGLDEENPDLEFYDKLPDADAYSRMYLARLPNYVWEAWSKLDDDAEIEIGTVRQWTDKDGNLRLQMRLRSDLEAHKKVPKEYNMDVVNHDVNNTFIFSEQDLPSFAAKNKERANALAQGIPAHLLRKQQKPTEQPAERGKRGAPYARRPIPKKTKIAGKVKHEVVCTPVQNAEASRFLSLRAQAAEQTQKRTKMIYGHPTQKLTNPKEWEEFLKTREKPTKAKKMENKATRWPENQLLDAIAQCFSEHKYWSIKAFRGRIPQPEAYLREGLEKIAVLHRSGTFANHWSLKPEYQNMLGSLPKPADDAAVPKAEELSDDEDEEDIKMEDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H3Q3</accession>
    <name>A0AAJ0H3Q3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_67183</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727011.1">
        <property type="nucleotide sequence ID" value="XM_062871185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H3Q3"/>
    <dbReference type="GeneID" id="87890014"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04330">
        <property type="entry name" value="RNAP_III_Rpc25_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.120:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000221">
        <property type="entry name" value="DNA-directed RNA polymerase III subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013238">
        <property type="entry name" value="RNA_pol_III_Rbc25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08292">
        <property type="entry name" value="RNA_pol_Rbc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb7-like N-terminal" evidence="7">
        <location>
            <begin position="9"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase III subunit Rpc25" evidence="8">
        <location>
            <begin position="83"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3311231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="201" mass="22886" checksum="8319B5CFDE7A818A" modified="2024-07-24" version="1">MFILTKIADLVQIAPDDFRKQSHIAIEDNLNAKYANKVVQKIGLCICLWDILWTSEGLVGQGDGMANVNVEFRMVVFRPFKGEVIVARIADQSPEGINLATNFFDDIFVPWTELPEGSEFEPNENIWVWKEEDQVMYFDNNEMVRFRVIAEEWHDQTPSKPVDAVEASEEEPLPVINSKPPYSITGSMNGAGLGCCLWWEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H403</accession>
    <name>A0AAJ0H403_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_520527</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dpy-30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726910.1">
        <property type="nucleotide sequence ID" value="XM_062868507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H403"/>
    <dbReference type="GeneID" id="87887336"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd22965">
        <property type="entry name" value="DD_DPY30_SDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007858">
        <property type="entry name" value="Dpy-30_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049629">
        <property type="entry name" value="DPY30_SDC1_DD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05186">
        <property type="entry name" value="Dpy-30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3311130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="149" mass="15369" checksum="952563FD93821526" modified="2024-07-24" version="1">MDSIPPPATHDTAMTDAPAFHTARQQPPIQQVQTPPAAPSPTPTPQIPAAAATAPPSTSRAASTHPEPAVGGSGMPSASAITPGFAMPSEAAAHGAPVRQYINSKITGVLLEGMKLVAREQPKDPLRVLGEFLLQRSRELEGTGRADIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H446</accession>
    <name>A0AAJ0H446_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="4 15">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B0T15DRAFT_521657</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 15">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Endoplasmic reticulum membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="4 15"/>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727277.1">
        <property type="nucleotide sequence ID" value="XM_062868573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H446"/>
    <dbReference type="GeneID" id="87887402"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031502">
        <property type="term" value="C:dolichyl-phosphate-mannose-protein mannosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23283">
        <property type="entry name" value="beta-trefoil_MIR_PMT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000034">
        <property type="entry name" value="Dolichyl-phosphate-mannose-protein mannosyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF50">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 15" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="247"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="283"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="612"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="683"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="712"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="17">
        <location>
            <begin position="336"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="17">
        <location>
            <begin position="413"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="17">
        <location>
            <begin position="482"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="809"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="890"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="905"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="929"/>
            <end position="958"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK3311497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="958" mass="107127" checksum="F94047D4677728BF" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H4E4</accession>
    <name>A0AAJ0H4E4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">TLC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0T15DRAFT_499528</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingosine N-acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727356.1">
        <property type="nucleotide sequence ID" value="XM_062867340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H4E4"/>
    <dbReference type="GeneID" id="87886169"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF11">
        <property type="entry name" value="CERAMIDE SYNTHASE LAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005225">
        <property type="entry name" value="LAG1_LAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="250"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="296"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="13">
        <location>
            <begin position="163"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="21"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="384"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3311576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="425" mass="48731" checksum="32E91FA098C7F811" modified="2024-07-24" version="1">MAAASTSWSLLSTSANALQVTADDGSSPRRRAKSNSLSRRRFSLSSGLAQSSRPVKQGKVPSRHTKRSGRSLRFLFRRTWALPLALILGFLSLYAINPTESNPVYHFLFLSYKLDHQDDQYGKGPWDLAFVSFYTIVLSFTREFIMHEVLRPLAHPGGIRSRAKQQRFMEQMYTACYIAFVGPLGLYTMKRTPGLWYFETRAMYEAYPHRTHQAVFKFYYLFQAAFWVQQAVVMLLGLERRRKDFRELVAHHIITIALIGLSYRFHFTYVGIAVYITHDISDLFLAVSKSLNYLTSPLQAPAFALCIIMWVYLRHYLNLHILASVATEFRTVGPFELEWATEQYKCGISQAVTFALLAALQVLNLFWLYCLFRSAYRFVVLGVAKDDRSEAEEEEEEVGETKRATALLEEAPAIRLVVTESELVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZ13</accession>
    <name>A0AAJ0LZ13_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carboxyphosphonoenolpyruvate phosphonomutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_259765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate</text>
            <dbReference type="Rhea" id="RHEA:16809"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="EC" id="4.1.3.30"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the isocitrate lyase/PEP mutase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3302956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718736.1">
        <property type="nucleotide sequence ID" value="XM_062863310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZ13"/>
    <dbReference type="GeneID" id="87882139"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046421">
        <property type="term" value="F:methylisocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000009">
        <property type="entry name" value="2-methylisocitrate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42905">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42905:SF2">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13714">
        <property type="entry name" value="PEP_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00061405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3302956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="327" mass="35403" checksum="E9D21E52060A8601" modified="2024-07-24" version="1">MTVLNITLEEDGYYYVNGNRQVPSVSLYMPAGATKLRRMLRETDDLIVCPGVYDGLSARVAMQLGFKALYMTGAGTTASRLGQPDLGLAQLYDMRTNAEMIANLDPFGPPLIADMDTGYGGPLMVAKSVQQYIQAGVAGFHIEDQILNKRCGHLAGKRVVGLEEYLARIRAAKFTKDRLGSDIVLIARTDALQQHGYDECIRRLKAARDIGADVGLLEGFTSKELARQAVQDLAPWPLLLNMVENGAGPVITTAEAKEMGFRIMIFSFACLAPAYLGIKNALERLKVEGRTGIPDGLGPKHLFEVCGLMDSVRIDAEAGGDAFANGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZ83</accession>
    <name>A0AAJ0LZ83_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Multicopper oxidase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_262094</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718828.1">
        <property type="nucleotide sequence ID" value="XM_062863351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZ83"/>
    <dbReference type="GeneID" id="87882180"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13854">
        <property type="entry name" value="CuRO_1_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13880">
        <property type="entry name" value="CuRO_2_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13901">
        <property type="entry name" value="CuRO_3_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000021">
        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000038">
        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF71">
        <property type="entry name" value="OXIDOREDUCTASE TPCJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042539031" evidence="7">
        <location>
            <begin position="18"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="10">
        <location>
            <begin position="72"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="197"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="422"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3303048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="582" mass="63930" checksum="8FCE1D10C9A57A9D" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZE8</accession>
    <name>A0AAJ0LZE8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SRP40, C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_539923</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719141.1">
        <property type="nucleotide sequence ID" value="XM_062869764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZE8"/>
    <dbReference type="GeneID" id="87888593"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039191">
        <property type="entry name" value="Nopp140-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007718">
        <property type="entry name" value="Srp40_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23216">
        <property type="entry name" value="NUCLEOLAR AND COILED-BODY PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23216:SF1">
        <property type="entry name" value="NUCLEOLAR AND COILED-BODY PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05022">
        <property type="entry name" value="SRP40_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Srp40 C-terminal" evidence="2">
        <location>
            <begin position="440"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="175"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="251"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="372"/>
        </location>
    </feature>
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        <location>
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            <end position="397"/>
        </location>
    </feature>
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        <location>
            <begin position="421"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3303361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="509" mass="53165" checksum="AC2CF3B5B0C63770" modified="2024-07-24" version="1">MSAPPAWLFSNNSALTANHQKAITSDNKTTMPGNKGNKKPKAGKAKGKASAIEKPAPTAEPPAQLMDLVESFLSEHDFADAHHAFTKQRAEKGWKKAADKPVSAEHHSLVTVFRAWETSLNAAGGKGIKSAVGKVTKVSSSSSSSSSDSESSESESEDNGDVEMKDVEEEEESSSSESSSSSSSDSSSDSESESESEDEDKEAEKHTAAPKQAATNPLKRKAVSESSDSSDSESSDSSSDEEPPAAKKQKVAAAPAEESSSESSSESTSESSSESSDSDSGSESEAESKAETKKPAATKAAAKDEDSSSDSSSSSSESESESPSESESDSESSSDSEDDAEEAAKVPLPESGSDSGSDSDSDSDSDSSDSDAEEKTKTSGNAKSGSPEANGSDSSATIGKPSPKIYPVDKFAPLPPDPASVKTNNRGKGSNNNEKKGIVPFSRVRRDVQVDPRLASNAFQGHDWGRKAHEDLVVTRGKSFTKEKNKKKKGSYRGGRIDTHAVGGIKFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZX5</accession>
    <name>A0AAJ0LZX5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyltransferase family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_541438</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719640.1">
        <property type="nucleotide sequence ID" value="XM_062869859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZX5"/>
    <dbReference type="GeneID" id="87888688"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050879">
        <property type="entry name" value="Acyltransferase_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028:SF134">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08520)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="288"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="388"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="424"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="458"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="3">
        <location>
            <begin position="88"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3303860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="509" mass="57492" checksum="63E4D68D4E62AEBB" modified="2024-07-24" version="1">MTRVAAKGPQFTMSSPPTRSSTEEKRARHEQPHELGDLEALQHVDQASTIDDRNSRRCVTPVGRLVLSLILRFIRYPLTGSLRLRPTSWLDGVRGVAAMAVYLFHAMGCWASVVPAWRADDAQTSFLQLPLVRTIFVAGGGAVSVFFVLSGYVLTQRCLRLIRAGSGRAVYPAVASSAFRRGFRLYLPPILLTFCEMLMSRLGFPPPLNFSFVPEPTLLGQFWDWLAETNRLVNPLYNFRRAIRGSVTHPKYDAVIWTIPVEFYGSMVCYILLSLLARVSSTGPRMGFIAVFCVLSMAFGYWNIFCFTAGMFVADINLGQEEDDTVIKTGRPPPRRTLLWSSAFAISFYLAGFPTLVYKEGRMKPMPGFETLRALIPAGLDMEDPARFWWSVAGAVLLLSVSQLPRLRAVFDTYLCQYIAKISFSLYLVHEFCIVLFGLRLQGFLLRVAGVDSQHKGVGYWIICLVWFALFTMPVFALAAQVERWIDVPSVKFAKWLEERCLRMHRSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M066</accession>
    <name>A0AAJ0M066_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 20">Glutathione reductase</fullName>
            <ecNumber evidence="4 20">1.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">B0T15DRAFT_231159</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15 20">Catalyzes the reduction of glutathione disulfide (GSSG) to reduced glutathione (GSH). Constitutes the major mechanism to maintain a high GSH:GSSG ratio in the cytosol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 20">
            <text>2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="17">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 20">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.7" evidence="4 20"/>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719909.1">
        <property type="nucleotide sequence ID" value="XM_062862947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M066"/>
    <dbReference type="GeneID" id="87881776"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000003">
        <property type="entry name" value="Glutathione reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000141">
        <property type="entry name" value="Glutathione reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000671">
        <property type="entry name" value="Thioredoxin reductase 2, tandem duplicate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006322">
        <property type="entry name" value="Glutathione_Rdtase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046952">
        <property type="entry name" value="GSHR/TRXR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01421">
        <property type="entry name" value="gluta_reduc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004776">
        <property type="entry name" value="PRK06116.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737:SF2">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 20" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 17 19" id="KW-0274">FAD</keyword>
    <keyword evidence="7 19" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-0520">NAD</keyword>
    <keyword evidence="9 20" id="KW-0521">NADP</keyword>
    <keyword evidence="17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13 19" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="22">
        <location>
            <begin position="44"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="21">
        <location>
            <begin position="391"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="16">
        <location>
            <position position="493"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="219"/>
            <end position="226"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="18">
        <location>
            <begin position="81"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00056905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU365016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAK3304129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="504" mass="54693" checksum="D344B257530A1E5D" modified="2024-07-24" version="1">MQPLSVLARRSLLSSRPAAGRISNISRHFSHTSLTMAPISKETDFLVIGGGSGGLGAARAASSRYGARAMVIEGKRLGGTCVNVGCVPKKVTFNAALIAETIHEAKSYGFSVQETAPFDWTSFKKKRDAYILRLNGIYERNLANDKVEYVHGWAKLLSRNQVEVTLDDGTKTVVNAKRILLAVGGNPTIPPQIPGSELGTNSDGFFDIDKLPKKVALVGAGYIAVEFAGMFNALGVETHLFIRHDTFLRAFDPMIQEGVTKEYERLGVKLHKRSAVQKVEKDEKTGNLSIHYKEGDSEGVVSDVNHLIWAIGRTPATKGIGLEDAGVKLNEKGYVVVDDYQNTSVDNIYALGDVTGQVELTPVAIAAGRKLAARLYGPEQFRTAKLDYNFIPSVVFAHPEVGSVGLTEPQAVEKYGRENLKIYKTNFTAMYYAMMDPEQKGPTSYKLICAGPEEKVVGLHIMGLGSGEMLQGFGVAVKMGATKADFDNCVAIHPTSAEELVTMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M0A4</accession>
    <name>A0AAJ0M0A4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome c oxidase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_494724</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome c oxidase subunit 6B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720029.1">
        <property type="nucleotide sequence ID" value="XM_062867033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M0A4"/>
    <dbReference type="GeneID" id="87885862"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00926">
        <property type="entry name" value="Cyt_c_Oxidase_VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.140:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit 6B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.140">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048280">
        <property type="entry name" value="COX6B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036549">
        <property type="entry name" value="CX6/COA6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003213">
        <property type="entry name" value="Cyt_c_oxidase_su6B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46281:SF8">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 12, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46281">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02297">
        <property type="entry name" value="COX6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000278">
        <property type="entry name" value="Cyt_c_oxidase_6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47694">
        <property type="entry name" value="Cytochrome c oxidase subunit h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="32"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000278-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3304249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="87" mass="10338" checksum="4D12A9DFD4EB25DA" modified="2024-07-24" version="1">MSDSDDERVTKPFKFVTGVDARFPNVNQTKHCWQNYVDYHKCILAKGEDFAPCRQFWLAYRSLCPSGWYERWDAQREAGNFPVRLDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M0L7</accession>
    <name>A0AAJ0M0L7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_243238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720268.1">
        <property type="nucleotide sequence ID" value="XM_062863092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M0L7"/>
    <dbReference type="GeneID" id="87881921"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3304488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="188" mass="20767" checksum="4DD2EDF407857F36" modified="2024-07-24" version="1">MAKAASLLSDRTCPVVSAELYLILIQLASRALAFESCTYVLPCSSSCRPLLLLAREALVDASWPRRLPFLNKWASSLASTTRKEHSRAEARLSDPAPSKDRTTLTKVPRRSGLVHYGGQAACGCYGHRCLKSLTGFPPWKCLASRYWVGDLRLPMLRTRSRVEMKHLGGLEGKDTSGQFHFFVPSADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M154</accession>
    <name>A0AAJ0M154_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Glycoside hydrolase family 2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_188829</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720897.1">
        <property type="nucleotide sequence ID" value="XM_062862418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M154"/>
    <dbReference type="GeneID" id="87881247"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032311">
        <property type="entry name" value="DUF4982"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048229">
        <property type="entry name" value="GalB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051913">
        <property type="entry name" value="GH2_Domain-Containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040605">
        <property type="entry name" value="Glyco_hydro2_dom5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006101">
        <property type="entry name" value="Glyco_hydro_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008964">
        <property type="entry name" value="Invasin/intimin_cell_adhesion"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041463">
        <property type="entry name" value="GalB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42732">
        <property type="entry name" value="BETA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42732:SF1">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16355">
        <property type="entry name" value="DUF4982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18565">
        <property type="entry name" value="Glyco_hydro2_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00132">
        <property type="entry name" value="GLHYDRLASE2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49373">
        <property type="entry name" value="Invasin/intimin cell-adhesion fragments"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042460213" evidence="4">
        <location>
            <begin position="36"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolases family 2 sugar binding" evidence="7">
        <location>
            <begin position="144"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="5">
        <location>
            <begin position="249"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 catalytic" evidence="6">
        <location>
            <begin position="369"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4982" evidence="8">
        <location>
            <begin position="706"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2" evidence="9">
        <location>
            <begin position="777"/>
            <end position="879"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3305117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="884" mass="95445" checksum="C998F788625CA47E" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M1E2</accession>
    <name>A0AAJ0M1E2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_193799</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721108.1">
        <property type="nucleotide sequence ID" value="XM_062862479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M1E2"/>
    <dbReference type="GeneID" id="87881308"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03357">
        <property type="entry name" value="LbH_MAT_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051159">
        <property type="entry name" value="Hexapeptide_acetyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024688">
        <property type="entry name" value="Mac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416">
        <property type="entry name" value="SIALIC ACID SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416:SF76">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12464">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01266">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="243"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="276"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="416"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="484"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="125"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="194"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="310"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="360"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="428"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="438"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="462"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="491"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3305328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="706" mass="77832" checksum="A05D4C681C119E2A" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M1U6</accession>
    <name>A0AAJ0M1U6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_213985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721680.1">
        <property type="nucleotide sequence ID" value="XM_062862708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M1U6"/>
    <dbReference type="GeneID" id="87881537"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3305900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="345" mass="38017" checksum="8500F9726B9A863C" modified="2024-07-24" version="1">MTTPYRLSIGIDFGVCTSGVSYCLLRPNEAVSSAVEIEFGGEGKTLVPSALGVNGNWGNDIAAGEDKFTLFKLKLLHTDDLLQSYRQTPEQLTFVRDALGKIERAGKTDIDVVAEYLRRLWAFAADSLSVILRRKGLISLSDLEARFVFGIPAVWGVDTRSRMEQAIQHSGLFKLGDRPPAPLDFIAEPEAAAIAMFPRLAVSYNLQDGQTVVICDCGGGTVDVISYEITSLEPLTVREIVSGEGQLLGDMFMKSALVALIKSRVQEDYRDNADLDLADLDNEIEAVWDRVSKIQGNTMRRAGWCHRLDITYVDGRIGRQVVLSGRDVLRALNTCTDSIVRLLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M248</accession>
    <name>A0AAJ0M248_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">5'-deoxynucleotidase</fullName>
            <ecNumber evidence="8">3.1.3.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0T15DRAFT_483694</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18274"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:65317"/>
            <dbReference type="EC" id="3.1.3.89"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the HDDC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.89" evidence="8"/>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722051.1">
        <property type="nucleotide sequence ID" value="XM_062866180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M248"/>
    <dbReference type="GeneID" id="87885009"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002953">
        <property type="term" value="F:5'-deoxynucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009159">
        <property type="term" value="P:deoxyribonucleoside monophosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3210.10:FF:000011">
        <property type="entry name" value="HD domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039356">
        <property type="entry name" value="YfbR/HDDC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845">
        <property type="entry name" value="5'-DEOXYNUCLEOTIDASE HDDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845:SF13">
        <property type="entry name" value="5'-DEOXYNUCLEOTIDASE HDDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13023">
        <property type="entry name" value="HD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0170">Cobalt</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD/PDEase" evidence="13">
        <location>
            <begin position="102"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3306271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="287" mass="32893" checksum="226ABD645DA4AC31" modified="2024-07-24" version="1">MPYTHLLEHPHILGYHQRLTPPDCGITLERRTSIYPDPLKGNSRPPSIVTTEKVEDPWTVEKALATIDRPAEGSTSPVPFFHLLERLKTTKRAGWMRFRIQRGGSVADHSWRMAMMAALPATSLACQLDIGKCIKMYLFHDMAESLVGDLTPADDVPKTEKHRREADTISYIEGKILHKVNAGGAGQELVDLWREFEEGKSLESRFIQDFDKIEMLLQMVEYERRAKGRLDLSEFTYVETKVLLPETQAWAKKIIGERKEFWKTHGSTEAGASEIRMRKMQDAYYSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M2A1</accession>
    <name>A0AAJ0M2A1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_136988</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAK3306303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_062861828.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acetyltransferase, GNAT family, putative"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Diverse_Substrate_AcTransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545">
        <property type="entry name" value="DIAMINE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545:SF29">
        <property type="entry name" value="GH14572P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="6"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="19"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3306303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="185" mass="20881" checksum="43B39EB1113C7EEA" modified="2024-07-24" version="1">MTPNDAIVRHARREDVPAILELIRELADYEHELHSVEATEAKLLETIAFALSDTSVVSTTRSPQTEPTSPSRPARCLILLTPAGEPAGIALYFYNYSTWRARPGIYLEDLYVKQSERKNGYGKRLLVELAREVVAMQGGRLEWSVLKWNEPSIKFYENIGARMMSEWVGMRVDGEALTKLAALLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M2H9</accession>
    <name>A0AAJ0M2H9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear segregation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_146652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722382.1">
        <property type="nucleotide sequence ID" value="XM_062861941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M2H9"/>
    <dbReference type="GeneID" id="87880770"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042175">
        <property type="term" value="C:nuclear outer membrane-endoplasmic reticulum membrane network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008298">
        <property type="term" value="P:intracellular mRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039604">
        <property type="entry name" value="Bfr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31027:SF2">
        <property type="entry name" value="LEBERCILIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31027">
        <property type="entry name" value="NUCLEAR SEGREGATION PROTEIN BFR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="455"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3306602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="499" mass="55647" checksum="AEE7962B9BCDA867" modified="2024-07-24" version="1">MATDSTAPASAAASAVPAPATKPVKPDEEAFKKELAKLEKEHKEAMDKYNAVRAKIELAVPNKDKESENPTQKRRQELIAEANEIRKKQAGGKASRTSKMEQIKRLDDQLKSRIAEQKAARAKVPYKSVEEIDQKIERLEREVGSGQMKLVDEKKALTEVSSLRKLRKNFSQFDDSQKAIDQLKNQIKEIKDSMEDPESKALSERYSKVQAELDAIKAEQDEVYKNLSALRKERDELRAKQQATYQAVKQLKDTYHTQRKAARAWELQQREKRREREQAERERIAKERKMERAKAMLDEASLPAYTEELRRASSLLRFLDPSYTEEATPLVADKGLAATAQRKVDASAFQGMRALRKEDRVEEYLPAVSKKGKKGKKSPAAAETPAAGKYSCPPSVIEDCAFIGVEPPMSATEVPAVAEKVKAKIAHWKADQEEQTKKNVEKAKKEIERLEAEEAASAPAEGSGASTPAKGVNGKEADQPVVEAAEQVLETPKEVAATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M330</accession>
    <name>A0AAJ0M330_9PEZI</name>
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        <submittedName>
            <fullName evidence="11">Choline dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_492737</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723030.1">
        <property type="nucleotide sequence ID" value="XM_062866878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M330"/>
    <dbReference type="GeneID" id="87885707"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF201">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0274">FAD</keyword>
    <keyword evidence="3 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="9">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="10">
        <location>
            <begin position="287"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="574"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="619"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="573"/>
            <end position="574"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3307250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="642" mass="68549" checksum="8155E838CB7A8485" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M331</accession>
    <name>A0AAJ0M331_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine-threonine rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_167484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722997.1">
        <property type="nucleotide sequence ID" value="XM_062862180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M331"/>
    <dbReference type="GeneID" id="87881009"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="710"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="270"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="720"/>
            <end position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3307217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="786" mass="86653" checksum="7A97B0FFE70F27DB" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M3F4</accession>
    <name>A0AAJ0M3F4_9PEZI</name>
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        <recommendedName>
            <fullName evidence="4">Sequence orphan</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_173218</name>
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    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
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            <taxon>Ascomycota</taxon>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723089.1">
        <property type="nucleotide sequence ID" value="XM_062862217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M3F4"/>
    <dbReference type="GeneID" id="87881046"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038781">
        <property type="entry name" value="C365.16-ike"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37845">
        <property type="entry name" value="SEQUENCE ORPHAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37845:SF1">
        <property type="entry name" value="SEQUENCE ORPHAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3307309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="34281" checksum="8C1E60732EEADCD8" modified="2024-07-24" version="1">MKDNTMGSLEAPGGPSQLQLAAVKPSSLTTTTPPAPPRTFSASTLTVQPEAGTSQAGKWNTKNLALRLGADAISAASAAVLIAPIISIIDRSIMENASGRRSLVASLKSSFRSLLLQPHRTILSKPFALIFALYGGTYLTANALDTATSTVRSLPATHVTSGTAKFAASSAANIGLCIYKDQVFVRLFGPPGITPRPVTLPSYMLFAARDCLTIFASFNVPPLLGPVLSRRVGDEVQRYVSGLTMAQFAAPAAVQLVSTPVHLLGLDIYNRPGIEGWRERWRAVRKNWAVSTAARICRIVPAFGVGGVVNLKVRRSLMERLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M3G8</accession>
    <name>A0AAJ0M3G8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cullin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0T15DRAFT_530664</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 12">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723387.1">
        <property type="nucleotide sequence ID" value="XM_062869186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M3G8"/>
    <dbReference type="GeneID" id="87888015"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000014">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000007">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000011">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000026">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.130:FF:000003">
        <property type="entry name" value="Cullin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000029">
        <property type="entry name" value="Cullin homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cullin family profile" evidence="13">
        <location>
            <begin position="411"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3307607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="768" mass="88045" checksum="4B3053750B43B466" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M3H6</accession>
    <name>A0AAJ0M3H6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_433456</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723480.1">
        <property type="nucleotide sequence ID" value="XM_062865775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M3H6"/>
    <dbReference type="GeneID" id="87884604"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000044">
        <property type="entry name" value="AP complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016342">
        <property type="entry name" value="AP_complex_bsu_1_2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002291">
        <property type="entry name" value="AP_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="8">
        <location>
            <begin position="31"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="601"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="643"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3307700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="716" mass="80155" checksum="CFD3A8722D4738EC" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M3L2</accession>
    <name>A0AAJ0M3L2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">enoyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="11">1.3.1.104</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0T15DRAFT_428110</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 2,3-saturated acyl-[ACP] + NADP(+) = a (2E)-enoyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22564"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.104"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.104" evidence="11"/>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3307742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723522.1">
        <property type="nucleotide sequence ID" value="XM_062865681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M3L2"/>
    <dbReference type="GeneID" id="87884510"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141148">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08290">
        <property type="entry name" value="ETR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051034">
        <property type="entry name" value="Mito_Enoyl-ACP_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43981">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43981:SF2">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="13">
        <location>
            <begin position="13"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3307742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="359" mass="38324" checksum="C1F999DB34D7D684" modified="2024-07-24" version="1">MAQSLVSVSGQPGTSGYHVISHPIPDSLEDGQVLVRFLAAPVNRVDLMVLAGQYPIKPKYTAPLADQHYPIPGFDGCAVVESSTSPLFTPGDLVLPRDLGLGTWRTHAVLSATAVLKLPEGRVDPIDAALIRSGALIARLLLDEAVSPPPRAGDYVIASAGTSCVAQFLVQLAQARGVRVILVVRDRPDEELAVVRERLCALGADRVVSESELERELASKTRVLLPQEPIVLALDSVFGTVGQLLAAALAPKGKFVLVGLLAGAKASMSLTTEHLFTRQLSFLPFRGSEVLKRMGDQRAQEIIDEITGMFVEGTLKRPGMKVVDWGKAGKGEVEEALESAVHAAEGDEVGHVKTVWKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M3T7</accession>
    <name>A0AAJ0M3T7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_508533</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723795.1">
        <property type="nucleotide sequence ID" value="XM_062867729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M3T7"/>
    <dbReference type="GeneID" id="87886558"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.30">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000026">
        <property type="entry name" value="N1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016191">
        <property type="entry name" value="Ribonuclease/ribotoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00545">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53933">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="9"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="161"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="204"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3308015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="219" mass="23442" checksum="86D51969FE6DDA06" modified="2024-07-24" version="1">MSSSRPKKTTTTTTTTTISHSGGGTRSSASTSAASSSATHKIPVKITDRNGQPYAGDPYETPGSPPFVRQGSYYETNSNNEEFKYLKASDVRRQAQQAPAQNASVGRYPKPFANHEKLNLTSQGPHKEFPLSPSPGASTSTSGKPPSNYRGGDPGPVRAVYSDDRKSVDVVYHDPNGAPVAPRKGRAKPSTPYAMAKYRESPTYADTSNVKPSSSTKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M447</accession>
    <name>A0AAJ0M447_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase M20 domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_105018</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724092.1">
        <property type="nucleotide sequence ID" value="XM_062861416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M447"/>
    <dbReference type="GeneID" id="87880245"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05672">
        <property type="entry name" value="M20_ACY1L2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.360:FF:000004">
        <property type="entry name" value="Peptidase M20 domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052030">
        <property type="entry name" value="Peptidase_M20/M20A_hydrolases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017144">
        <property type="entry name" value="Xaa-Arg_dipeptidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575">
        <property type="entry name" value="PEPTIDASE M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575:SF0">
        <property type="entry name" value="XAA-ARG DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037226">
        <property type="entry name" value="Amidohydrolase_ACY1L2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="3">
        <location>
            <begin position="181"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3308312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="407" mass="43533" checksum="8D4985BCB5E16F71" modified="2024-07-24" version="1">MPLDISAIIDSELHARNAEISTINHQIHSHPELAYEEIHAHDTFVRILSTLGFDVTPHAYGLETAFSADFGHGGRLIVFNAEYDALPDIGHACGHNLIASASFAAFLGLAAALRASNQPGRVRLLGTPAEEGGGGKLKLIQAGAYQDAAASLMVHPGPGHKLPTSNSIRGVSFVRMLANVKMRAHFTGREAHAAIAPWDGINALDAVCLSYNAISMLRQQTRPYERIHGVFVSAGKRPNVTPADCSVEYYVRSATRAEAAALWGRVRKCFEGAAMATGCGVEFESLNSYADVRPSRALCEAYVEAMPRGTVAFDQPADILAGSTDMGDVCYECPGFHGVFGIGTKEGEANHTKGFAAAAGTDDAFQRALECGRGMALVGWKVLSDDGFAEKVRKEWEEDMKLAAEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M4F4</accession>
    <name>A0AAJ0M4F4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">serine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Seryl-tRNA synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Seryl-tRNA(Ser) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0T15DRAFT_483269</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="2"/>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724438.1">
        <property type="nucleotide sequence ID" value="XM_062866149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M4F4"/>
    <dbReference type="GeneID" id="87884978"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000026">
        <property type="entry name" value="Seryl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="entry name" value="Serine-tRNA synthetase, tRNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="SERYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="tRNA-binding arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="179"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="49"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="259"/>
            <end position="261"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="275"/>
            <end position="278"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="343"/>
            <end position="346"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="379"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for serine binding" evidence="10">
        <location>
            <position position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3308658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="434" mass="49699" checksum="C16261FE134CA030" modified="2024-07-24" version="1">MLDVNDFIAERGGNPELIRASQRKRHASVAAVDEVIEMFEDHRKTAYAATQINAKINEAKEDVTDLLKQKADLEKEKKDLLASAAEKEKLLKAKVRLIGNIVHESVPVSDNEDNNRVERTWAPEGVLFEKRNVLSHHEVLDKLEGYDPERGVKVVGHRGYFLRKWGVFLNQALINYGLEFLNDRDYIPLQTPQLMLRDQMAKTAQLSQFDEELYKVTGDQADKYLIATSEQPISAYHSDEWLQPKQLPLKYAGYSTCFRKEAGAHGKDVWGIFRVHEFTKVEQFCITDPEKSWEMFDSMISTSEEFYKSLGIPYRVVAIVSGALTAKKLDLEAWFPHQGEFKELVSCSNCTDYQSRDLEIRFGIKKQTDVKKTYVHCLNSTLCATTRTICAILENFQTEDGVRIPEPLRKYLPGAPDFIPFSKPVVEKKEVVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M4G5</accession>
    <name>A0AAJ0M4G5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Feruloyl esterase C</fullName>
            <ecNumber evidence="11">3.1.1.73</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Ferulic acid esterase C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0T15DRAFT_429268</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Involved in degradation of plant cell walls. Hydrolyzes the feruloyl-arabinose ester bond in arabinoxylans, and the feruloyl-galactose ester bond in pectin. Active against paranitrophenyl-acetate, methyl ferulate and wheat arabinoxylan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>feruloyl-polysaccharide + H2O = ferulate + polysaccharide.</text>
            <dbReference type="EC" id="3.1.1.73"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the faeC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.73" evidence="11"/>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724230.1">
        <property type="nucleotide sequence ID" value="XM_062865703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M4G5"/>
    <dbReference type="GeneID" id="87884532"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043595">
        <property type="entry name" value="FaeB/C/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38050:SF1">
        <property type="entry name" value="FERULOYL ESTERASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 11 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 11" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042492224" description="Feruloyl esterase C" evidence="11">
        <location>
            <begin position="26"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="231"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3308450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="296" mass="31209" checksum="3A23D10F3616FA99" modified="2024-07-24" version="1">MTRSLRQVLLSATAMIVAALHGVTAAKPSAGCGKTPTLITGGAATTPLTLTSNGKTRQYYVKLPDNYDNSHPYRLIFTLHALGGNAQQVTVGTGGYLPWYGIPALANNDTVGAVYISPNGLNNGWANQGGEDVAFLKAVMDTVESDLCIDQNLRFSTGFSYGAAMSYSLACSLGRQIRAVAVLSGNPTISGCAGGTEPVAYYGQHGIKDSVLPIAGGRQMRDRFVKNNGCAAQSSAPPEPASGSGKHVKTAYTGCDPNYPVVWNAFDGDHTPQPKDQGAQNTFSAVETWEFFSQFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M500</accession>
    <name>A0AAJ0M500_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_526749</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3309271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725051.1">
        <property type="nucleotide sequence ID" value="XM_062868923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M500"/>
    <dbReference type="GeneID" id="87887752"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF49">
        <property type="entry name" value="LYSINE BIOSYNTHESIS REGULATORY PROTEIN LYS14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="24"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="116"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="116"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="455"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3309271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="598" mass="66593" checksum="69C4E8CBEC05D74B" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M5A9</accession>
    <name>A0AAJ0M5A9_9PEZI</name>
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        <recommendedName>
            <fullName evidence="3">Nuclear pore protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_545201</name>
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        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
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            <taxon>Sordariomycetes</taxon>
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            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
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    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725219.1">
        <property type="nucleotide sequence ID" value="XM_062870123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M5A9"/>
    <dbReference type="GeneID" id="87888952"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3309439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="326" mass="37108" checksum="FD12ACB11B15300D" modified="2024-07-24" version="1">MEVFDPRGDLELVIGPEKTVFQVCSRALARSSPVWDVMLYGSFAEEDSVEGLRLALHAAHGNLTEIPPVLPQATLYAAVTVADKYDMVECLTPWWRGWIDALPDPRPDPHVLVQRLLIFCLLGDECRYRMTLKILLSCSRRDPKSGSIWSDRQEYDLRQDSDLDYLEISPHLESARHTLFSAVGKHMRHAMERLINHEASCCKSKRNKKWKRTCDCAMLGAVLRMATAMEVEAWFERGRDDDFSVHTSDSLFSLIVQLENMRHSVIDESGMSGKQNGAHRTCTPWPPFEIIDIWAEHPVEDLFPINPSQFLTRCDRLAIGGTDGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M5E7</accession>
    <name>A0AAJ0M5E7_9PEZI</name>
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        <recommendedName>
            <fullName evidence="8">Monooxygenase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_3662</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725232.1">
        <property type="nucleotide sequence ID" value="XM_062864174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M5E7"/>
    <dbReference type="GeneID" id="87883003"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051820">
        <property type="entry name" value="FAD-binding_MO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43872">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G02570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43872:SF1">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G02570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3309452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="500" mass="55770" checksum="88A5CA201577F5A0" modified="2024-07-24" version="1">MVPEPETLDIIIVGAGLTGINSAYRLQTELPHRSYGILESRSEIGGTWSFWNYPGVRTDSSMALFGFPWRPWPHNTNVAGGPAIRKYMEECAVAEGIDKKIRFGHRIVASNWSSAEQRWTLQVEVTHPGGDIERKVFKAWWVINGSGYYSYEKPLPAVIPGIEKFGGKVVHPQFWDESVDYAGKRLVVIGSGATAVTLFPTLAKTAKSITLLQRTPSYVLSMPFKDRVVAFWSKLLPLRWARSVNWWLRMVIETLFVRFLLTFPRAGRRFLVSEMRKQLPEGFDVNKHFNPWYNPFEQRLCFCPGGDFFKTLHQPNARIVTDAIDTVTETGILLKSGETLEADVIITATGLYFALLAGVAATVDGVSINDTIANRYIWNGVMLEGVPNTGLITGYTAATWTPGADVRVRQLIKVIKHMEKTGATAAAPYIDPTERTGLPIKPAVGLNSTYMVAAYDRTPKQAGRAPWINGSNWAGDMWRLVTGSVEKGMKFTFGSKKKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M5N6</accession>
    <name>A0AAJ0M5N6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Lytic polysaccharide monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_424813</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725609.1">
        <property type="nucleotide sequence ID" value="XM_062865623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M5N6"/>
    <dbReference type="GeneID" id="87884452"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182:SF2">
        <property type="entry name" value="LYTIC POLYSACCHARIDE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042564662" description="Lytic polysaccharide monooxygenase" evidence="2">
        <location>
            <begin position="23"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3309829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="452" mass="46964" checksum="29E85B796856042F" modified="2024-07-24" version="1">MMSSLVSATGVAMLYLLDGAGGHMVMNKPVPYNLHMAPLLQVNPISSGLYPFPCHNKYDFTERTPVEAGGTTLVNFTGGAQHGGGSCQFSITYDEPVDGGDWNKSAVFKTIYSIIGGCPAAFTDETHNLAPVTPDENLRQDGKHCGNDAGIDCIRQFRIQIPKFVKNGPATFAWTWFNKIGNKEMYMNCAPVYITGGTDDAEQLNSLPNIFIANYPNDPAVPNCITGTSADKVVVNFPNPGKYGRVLEPPLEPATKPANYCTEIPPPSQIPTFLPGLPPQDGNDDNHHTASSSASKITTTTTTPSSTTTTSAAWSVGPVISAEAPPANATIPRIVSTSPPAKTLPTTIATTFVVVESTSIDFATVAAETTDPAVNTTATATATATVPVAGGGGGGGGGKGKGRVVPCPAEDNGKVVCVGGGGDQFGLCDKGWAAVQAVAEGTKCRGGDIVYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M5Q0</accession>
    <name>A0AAJ0M5Q0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450 monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_506585</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725625.1">
        <property type="nucleotide sequence ID" value="XM_062867590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M5Q0"/>
    <dbReference type="GeneID" id="87886419"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002974">
        <property type="entry name" value="Cyt_P450_E_CYP52_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002402">
        <property type="entry name" value="Cyt_P450_E_grp-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF18">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE APDE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00464">
        <property type="entry name" value="EP450II"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01239">
        <property type="entry name" value="EP450IICYP52"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602402-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3309845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="502" mass="57576" checksum="B3433C0DC532CFB8" modified="2024-07-24" version="1">MLSATLAFGCAALLATCYYGLIRLYDAWQYDRKRREHCCPKMPHYKHRDPILGLDFVYAMVSALKEDRFLPFWKDLFASQGRKAFTATFMGARMVYTTESENMKAMSTSQWEDFGVQPIRLANGASLPFTMHGVSTTDPPLWEYSRNLIKPYFERAGYANLARLEVHVDNLISLLPSDGSSFDFQPLVKRWFLDTSTEFLFGQSIHSLQDPDKAEVAWAMMDVQEGLRLRLQLGRLVHFHHDAKWLAKVDLVHRFLDAHIDKTLAEVAKCKEAGSALSDRTDLLWVMANKLPDKLPLRSQLIGVWVPSNDTTSVLISNAVYALARHPRVLKKLRDEILEHAPPGKPITWEQLRSLRYLRYVINETHRLYPNSLQMVRIALRDTTLPTGGGPRGDRPIFIRKGDVVHVNRYLMHRDPDTWGPDAEEFRPERWESERPMWRFVPFGGGPRICPAHVLVDTEASYVLLRLLQQFRDIVPRDDRPYAAVMRIGPSLSWEDGKGGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M5X3</accession>
    <name>A0AAJ0M5X3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetylglucosamine-induced protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_388843</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725850.1">
        <property type="nucleotide sequence ID" value="XM_062864461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M5X3"/>
    <dbReference type="GeneID" id="87883290"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022036">
        <property type="entry name" value="DUF3605"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35020">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-INDUCED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35020:SF4">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-INDUCED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12239">
        <property type="entry name" value="DUF3605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3310070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="221" mass="26255" checksum="AD91F866A7151436" modified="2024-07-24" version="1">MGSAAEDLPYWQVNVPEHLRTAECPEFLRDITEKDRRIISTPDSEFELDSWEVVRQKVAQNRLELFQRVPSDLRRYHAFTWKLKQDYGSVMNFILTQRLQWTLPITPRGRPFEFDDDIKVLRNDWPYGIDRRIVHLVVWTKFALEEDPETGDLTDKARAEIDAYVRIVFSRIPQDHVVWFKNWASLKSVKSVEHFHIMLFDPDPEVIREITNGDVPLCEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M5Y1</accession>
    <name>A0AAJ0M5Y1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pre-mRNA-processing factor 39</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_389451</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PRP39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725894.1">
        <property type="nucleotide sequence ID" value="XM_062864490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M5Y1"/>
    <dbReference type="GeneID" id="87883319"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000243">
        <property type="term" value="C:commitment complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030627">
        <property type="term" value="F:pre-mRNA 5'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000395">
        <property type="term" value="P:mRNA 5'-splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000451">
        <property type="entry name" value="mRNA splicing protein (Prp39), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000064">
        <property type="entry name" value="Putative pre-mrna-processing factor 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059164">
        <property type="entry name" value="HAT_PRP39_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17204">
        <property type="entry name" value="PRE-MRNA PROCESSING PROTEIN PRP39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17204:SF5">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23241">
        <property type="entry name" value="HAT_PRP39_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23240">
        <property type="entry name" value="HAT_PRP39_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3310114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="587" mass="68786" checksum="8D5866976809B0BE" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M614</accession>
    <name>A0AAJ0M614_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Prohibitin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_406986</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Prohibitin probably acts as a holdase/unfoldase for the stabilization of newly synthesized mitochondrial proteins. Involved in mitophagy. Required for the switch to necrotrophic growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">The mitochondrial prohibitin complex consists of two subunits (PHB1 and PHB2). The subunits assemble into a membrane-associated ring-shaped supercomplex of approximately 1 mDa. Interacts with ATG24/SNX4; the interaction is direct and plays a role in mitophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the prohibitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725907.1">
        <property type="nucleotide sequence ID" value="XM_062865319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M614"/>
    <dbReference type="GeneID" id="87884148"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035632">
        <property type="term" value="C:mitochondrial prohibitin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03401">
        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000001">
        <property type="entry name" value="Prohibitin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PROHIBITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222:SF1">
        <property type="entry name" value="PROHIBITIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="9">
        <location>
            <begin position="61"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00053189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00066275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3310127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="314" mass="34405" checksum="BC84C33050154744" modified="2024-07-24" version="1">MSNRNPFEEYANKLREAARASSRGGFPAGGRFPGGGSPRGLGSGLAGLLLLGGGALIFQNALFNVDGGHRAIKYRRISGVSKDIYGEGTHFVIPWFETPIVYDVRAKPRNVSSLTGTKDLQMVNITCRVLSRPEISALPQIYRTLGQDYDERVLPSIVNEVLKSVVAQFNASQLITQREMVARLVREAMARRAARFNILLEDVSLTHLAFSPEFTAAVEAKQVAQQEAQRAAFIVDKARQEKQAMVVKAQGEARSAELIGEAIKKNKAYVELKKLENARAIAGLLQEAGGKNRLLLDSEGLGLNVFEDRPNDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M672</accession>
    <name>A0AAJ0M672_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cyclin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_32256</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin AB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726072.1">
        <property type="nucleotide sequence ID" value="XM_062864065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M672"/>
    <dbReference type="GeneID" id="87882894"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044772">
        <property type="term" value="P:mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20568">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20512">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000001">
        <property type="entry name" value="G2/mitotic-specific cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000005">
        <property type="entry name" value="G2/mitotic-specific cyclin B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046965">
        <property type="entry name" value="Cyclin_A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001771">
        <property type="entry name" value="Cyclin_A_B_D_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 5" id="KW-0195">Cyclin</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="257"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="8">
        <location>
            <begin position="350"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="354"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="92"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="153"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3310292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="486" mass="54551" checksum="0389A49B12682C3E" modified="2024-07-24" version="1">MPVRTRNPRSVTNENDENSNATARVTRAKSAATLTVDELAIPTKALQTKKGATNANPTRKRAALGDVSNVTKVEPTEGKKPVGRTGLVSKAAQPTGIQKKTTTTRSTTTSKEVNKKTETKRSGPGSIVAQKRKTLSTTTTNTVVKDENSEEGEPIRKKAHTLDAEKKTKTEVKTDEPARKDAVLVEAPVASEVEEPGLPEAIQALDSEDLDDPLMVAEYANDIFEYLRDLEVKSVPNPQYMSHQDELEWKTRGILIDWLVEVHTRFHLLPETLFLAVNIVDRFLSEKVVQLDRLQLVGITAMFIASKYEEVLSPHIANFRHIADDGFTENEILSAERFVLATLNYDLSYPNPMNFLRRISKADNYDIHSRTVGKYLMEISLLDHRLLAYRPSHVAAAAMYTARMILNRGPWDATLVHYAGYTEEEIQPVFLLMVDYMSRPVIHEAFFKKYASKKFLKASITSRQWAKKNASLYGIVDNHLPLDEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M6H3</accession>
    <name>A0AAJ0M6H3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_43105</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726372.1">
        <property type="nucleotide sequence ID" value="XM_062865732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M6H3"/>
    <dbReference type="GeneID" id="87884561"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042535585" evidence="3">
        <location>
            <begin position="23"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3310592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="406" mass="42265" checksum="C05A739360D88B11" modified="2024-07-24" version="1">MPGRGLALWVASFAAVRMAASAALMNDLFMRQSSCAPNFNECKNADFPPYFCCGSGQSCIALAGNTTVLCCPNGARCQRLQPIPCDISLQDGEKYPDAVVKTTALRGTLGRCGAQCCPFGYSCKSDECIMDVDQNAVPIQTAKPNPTSTASSKTSAPTDAGSSQTPDSTNGADDSSSDQESGSNGGPPIAAIAGGAAGGAVILIGAAVLAFIFLRKKKNASESGSPSKFSRSTSSFGNLISGPIVAEDTTLRSDFARVSPRQTSEDPASVTAALIDSSVTSPESGAGVLAAPPTAAQKPERQSSAPYGSFEPSAYVDMPYADYDSGGLMPHNPQQNREPSSVSINVFADPNITPDRTPESNADRRYTNMTTFTQMLDSAGLDGVARGDPYLPYQPESEQGTPMPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M6M3</accession>
    <name>A0AAJ0M6M3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosomal protein s17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_482041</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
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            <taxon>Sordariomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726629.1">
        <property type="nucleotide sequence ID" value="XM_062866069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M6M3"/>
    <dbReference type="GeneID" id="87884898"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053216">
        <property type="entry name" value="Appressorial_penetr-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34587:SF2">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34587">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042487087" description="Ribosomal protein s17" evidence="2">
        <location>
            <begin position="20"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
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        <location>
            <begin position="68"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="336"/>
            <end position="360"/>
        </location>
    </feature>
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            <end position="375"/>
        </location>
    </feature>
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        <location>
            <begin position="376"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3310849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="490" mass="48562" checksum="85B6F7C41F3172A4" modified="2024-07-24" version="1">MLMKTAVTALLGLTLAAEAASIHQHRSPVQLEQRQNRGGNRFGGGFGGGFGQGNNAGNNAGNNGGNQGNNNNNNNNNNNNNNNGGNNNNNNNGASQTCLAANALQTGSQSTGQSGGAPADGQVNSATDNANFINFCAGQTLTNGLQNRDGSCNGIPMGKIPAFNKMVSTVILNPKNNDNIQPLTTFQIQVQIANMKLGSFTNATSTYYSAPQDLAADGTVIGHTHVTVQDTGNTLNPTRPLDATQFAFFKGINDAGNGQGLLSTEVTGGLPAGCYRICTMSGASNHQPVLMPVAQRGAQEDCRYFSVGGACGNGGNGGNGGNGGNGGNGGNGNNGGNNNNNNNNNNAGGNNGNNRGNNAGNNGGNNGGNNAGNNGGRNNAGNNNNQGRGGGRNNGNNGQNNAAANGGAGAGGAAGAIGGIAAPAVQNTGNGARPFSVNGNTFANKAAAVQRACAIQNNACADAVNSGKVQGKTVGDCNTQEAACRAAGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ0M6T5_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
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            <taxon>Ascomycota</taxon>
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        </lineage>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M6T5"/>
    <dbReference type="GeneID" id="87890001"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="chain" id="PRO_5042552284" evidence="1">
        <location>
            <begin position="20"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3311208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="162" mass="17584" checksum="B2AFD10CADAD374E" modified="2024-07-24" version="1">MPNLCHCAILLGHLPCLQGLLRNDGSSRGCNSLLMAINLCHRAVPAIKVLVASIRLHAGLLPAERLSVLFGWDEFHAPQAEPATMAPGLARFKAAGGTRSSVRPKIISYSHKHMKKPRRILWAMTLKSTGRLGLVSLTGWLTTMVPSVQRHSAMHPSGTQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M6U4</accession>
    <name>A0AAJ0M6U4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chaperonin 10-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_389355</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727018.1">
        <property type="nucleotide sequence ID" value="XM_062864484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M6U4"/>
    <dbReference type="GeneID" id="87883313"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF3">
        <property type="entry name" value="ENOYL REDUCTASE (ER) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="4">
        <location>
            <begin position="21"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="351"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3311238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="387" mass="41886" checksum="4E38E7EEAFFC1C4D" modified="2024-07-24" version="1">MATTTLPSSVPDTHPAIVITAPRQPLQLLSRPTVPPKDGEALVHVTWTSSSPLDLHRADGGLALGTPPFVMGISFGGTVVALGGSKPTHLSVGDKVVGFVQDGAPDEAGFQTYITLPIWKVSKVPASMTLPEAVTVPANLVTAFHTITEDLGLDLPWPLPQGWTPPQAQERILVWGAASSVGMYVLQVLRHWGYRNVLAVASGKHHELLKGLGAKECFDYRNGNVVEEIARYLADAEGSASSAGRPRVPFFVDCIGSREGTLRPLSKIAEPGSKVAIMLPVINVHAGDEQVPEYEGDVSKVLPGDWAEGVELRGTRTFFYAKNEFFKHHLQPEIVPALLEQGVVQPNKHRIVEGNTLLERAENALKLLRNQAVSGERLVWRIADEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M6W6</accession>
    <name>A0AAJ0M6W6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit H</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_69156</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase H subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727076.1">
        <property type="nucleotide sequence ID" value="XM_062871217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M6W6"/>
    <dbReference type="GeneID" id="87890046"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000326">
        <property type="entry name" value="V-type proton ATPase subunit H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.150:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.150">
        <property type="entry name" value="V-type ATPase, subunit H, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004908">
        <property type="entry name" value="ATPase_V1-cplx_hsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011987">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038497">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11698">
        <property type="entry name" value="V-ATPase_H_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03224">
        <property type="entry name" value="V-ATPase_H_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF032184">
        <property type="entry name" value="ATPase_V1_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase V1 complex subunit H C-terminal" evidence="6">
        <location>
            <begin position="358"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR032184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF11698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3311296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="479" mass="53441" checksum="8BB8CFC0299DA793" modified="2024-07-24" version="1">MLFDPPAYLASLQNNIRQRPIPWDHAVRAGTLTEDQLARIRAVDKVKKDVRKQTVEADLGGYRTLFVGGSGTKSVLESASKRHDVVQYILVLLSDLLDGIPALAKAILETGDPYRHFLPLLAHSSNTEDPIPLLTSIVLISLMAGSRDESPATVDKAMPVIFSYLSSLTKSSDAGLQDIGVQEYSALLYGRAPRRQFWKQRSETVTPLIDILRAAAGVGNGDSSASLWSGTTGTARSGLEGSLGGGVGLQLLYRVLLVMWQLSFEAVEIGDDLNDEYDIVLLYTQLLRLSPKEKTTRLLVSTLLNLLVNNQNTLLPTAILARLPALLQNLKTRQFADPDLREDMDQLRELLDEYSKTKTTFDEYVGELNSGHLRWSPPHRSTVFWAENARRILEHDNGALIRKLADIMKKPWDNDKAVLAIACNDVACLVREVPERRSQLERLGIKTRIMELMGEADENVRWESLRALGGWLRYSFDPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M7G5</accession>
    <name>A0AAJ0M7G5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_522228</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727452.1">
        <property type="nucleotide sequence ID" value="XM_062868609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M7G5"/>
    <dbReference type="GeneID" id="87887438"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3311672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="152" mass="17335" checksum="1907653D6496D7E5" modified="2024-07-24" version="1">MAKCQHSGCHTTTAFANEAALVTHIADFHNQVSVCKMCGKDLKNAESVKRHEKMHNKMGHFKCLLPGCSATSWRKELIGSHLLNHKTELREVLNVFARFKDREDELQKAIELYEEFKDDIDVLRAALHLYKEFTKDMDMAAEHAKHANNAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GKB6</accession>
    <name>A0AAJ0GKB6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">GPI ethanolamine phosphate transferase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0T15DRAFT_544004</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI second mannose.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Endoplasmic reticulum membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the PIGG/PIGN/PIGO family. PIGG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717335.1">
        <property type="nucleotide sequence ID" value="XM_062870035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GKB6"/>
    <dbReference type="GeneID" id="87888864"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051267">
        <property type="term" value="F:CP2 mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16024">
        <property type="entry name" value="GPI_EPT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000045">
        <property type="entry name" value="GPI ethanolamine phosphate transferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037674">
        <property type="entry name" value="PIG-G_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039527">
        <property type="entry name" value="PIGG/GPI7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045687">
        <property type="entry name" value="PIGG/GPI7_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23072:SF0">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23072">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19316">
        <property type="entry name" value="PIGO_PIGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 13" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="448"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="474"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="503"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="527"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="564"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="595"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="644"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="674"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="763"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="811"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="851"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="domain" description="GPI ethanolamine phosphate transferase 2 C-terminal" evidence="14">
        <location>
            <begin position="440"/>
            <end position="878"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00056729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU367106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF19316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3301555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="884" mass="96479" checksum="1FEC93939F282F61" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GKQ8</accession>
    <name>A0AAJ0GKQ8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_570009</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717511.1">
        <property type="nucleotide sequence ID" value="XM_062870825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GKQ8"/>
    <dbReference type="GeneID" id="87889654"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3301731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="196" mass="22412" checksum="B3BFA26D2A2A14F3" modified="2024-07-24" version="1">MEFNPPRAIVHNEGCDLHYWYQGTGPPHHLRARRQWPRPAVQQHDRRPIRQIHTCATFDRRQMPASQVRLSIPQQAQDIRAVITAVGGAFDKPRASFGARLLGYDDEDEGVPKTVPPEPENEFPALLGYVPNLWRLRRNGTSIGVSVRAVRSKAKILECPKLLVLGHHHGFGVEAKEFLTYLLYMLEILEDRRRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GL44</accession>
    <name>A0AAJ0GL44_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ras family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_541508</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3301931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717711.1">
        <property type="nucleotide sequence ID" value="XM_062869861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GL44"/>
    <dbReference type="GeneID" id="87888690"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01860">
        <property type="entry name" value="Rab5_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000611">
        <property type="entry name" value="RAB GTPase Vps21/Ypt51, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="199"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3301931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="233" mass="24710" checksum="E2B735EEAE75A3A4" modified="2024-07-24" version="1">MADSNTPKPSSSVKLVLLGEAAVGKSSLVLRFVNNDFQENKEPTIGAAFLTQKCNLPTRTIKFEIWDTAGQERFASLAPMYYRNAQAALVVYDLTKPTSLIKAKHWVAELQRQASPGIVIALVGNKLDLTNDGAGSGGDADGAGSEDSGDARKVTTEEAKTYAEEEGLLFFETSAKTGYNVTEVFTAIANAIPETSLKTARGPGVSHAAGRTEEQRVNLNGPQDPNAKAGCAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GL95</accession>
    <name>A0AAJ0GL95_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_289301</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">Eukaryotic pyruvate dehydrogenase (PDH) complexes are organized as a core consisting of the oligomeric dihydrolipoamide acetyl-transferase (E2), around which are arranged multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide dehydrogenase (E3) and protein X (E3BP) bound by non-covalent bonds. The Chaetomium thermophilum PDH complex contains 60 E2 units, 12 E3BP units, about 20 E1 units, and 12 or more E3 units. The units are organized in 1 E2 60-mer, 4 E3BP trimers, about 20 E1 tetramers, and a maximum of 12 E3 dimers. The E3BP trimers are bound inside the icosahedral core with tetrahedral symmetry.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717798.1">
        <property type="nucleotide sequence ID" value="XM_062863686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GL95"/>
    <dbReference type="GeneID" id="87882515"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004742">
        <property type="term" value="F:dihydrolipoyllysine-residue acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000010">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151:SF82">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE COMPLEX PROTEIN X COMPONENT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="4" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="7">
        <location>
            <begin position="37"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="8">
        <location>
            <begin position="178"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="121"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="130"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3302018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="433" mass="45684" checksum="F1E45FA5F7D5BB28" modified="2024-07-24" version="1">MASFAAACRLSARLATRKLQSDAAVRGFRTSAIALAAQNFTMPALSPTMTEGNIATWRVKEGEKFSAGDVLLEIETDKATMDVEAQEDGILMKIMQGDGSKGVQVGTRIAVVAEEGDDISSLEIPADVSPQRTQTAEAPNVYETQTSAAPEPEAAPPSTAGPKAAAKPGAKTMKHNYPLLPSVAHLVKENGLDESDISGIIPTGPNGRLLKGDVLAYLGKINAKIPSEISSRFDKASHLDLSNIKVAKAPEPKMPLKEAAPVPPPVPVKSLVTLPVSLSAVIEAQQKIQKSLGVFLPLSTFIARATEIANDELPLPAGYQPTVDELFNQVLGLDKVTGPKVSRGSYIPQIAAIPPASALPTRSALAKKVDIIDILAGGTSKPKRAAKTTVIPGASTGPNVFSLQVPKTEERRAQVFLERVKLVLENEPGRLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GLE5</accession>
    <name>A0AAJ0GLE5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Concanavalin A-like lectin/glucanase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_541928</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717871.1">
        <property type="nucleotide sequence ID" value="XM_062869897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GLE5"/>
    <dbReference type="GeneID" id="87888726"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005537">
        <property type="term" value="F:D-mannose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07308">
        <property type="entry name" value="lectin_leg-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000095">
        <property type="entry name" value="Lectin family integral membrane protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051136">
        <property type="entry name" value="Intracellular_Lectin-GPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005052">
        <property type="entry name" value="Lectin_leg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223:SF45">
        <property type="entry name" value="RE50040P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223">
        <property type="entry name" value="VESICULAR MANNOSE-BINDING LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03388">
        <property type="entry name" value="Lectin_leg-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51328">
        <property type="entry name" value="L_LECTIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042459620" evidence="7">
        <location>
            <begin position="22"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="L-type lectin-like" evidence="8">
        <location>
            <begin position="29"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3302091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="314" mass="35236" checksum="62FD50845CC22992" modified="2024-07-24" version="1">MLKSTLSALWLATLAWGAVQADEDGNVKSIGLRTHTLVQPYLDSDMQSRWYDFGGDTIIRTDQYIRLTSDHPSQNGWLFSRVPLTATNWEVEVEFKIHGKNQLYGDGFAMWLTKERGKVGPVFGSADKFEGLGIFFDTYKNNRPGVVFPYVMAMVGDGKTSYDKDTDGKDTEFAGCSARGIRHASVPTKLRLTYFQDKYLKLELQYKSEGEWSLCFETSEPPAIPQVAYLGFSAETGELSDNHDIISIRAKNLYTAQPSGKSTPGSGRGKKTATKEGGSWTWFFMKVFFFFALIGGGYVGYTAWRANSKRSHRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GLV1</accession>
    <name>A0AAJ0GLV1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_542687</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718128.1">
        <property type="nucleotide sequence ID" value="XM_062869938.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87888767"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd07609">
        <property type="entry name" value="BAR_SIP3_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PH_SIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transcription factor SipA3"/>
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    </dbReference>
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        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039463">
        <property type="entry name" value="Sip3/Lam1_BAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042067">
        <property type="entry name" value="Sip3_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031968">
        <property type="entry name" value="VASt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14248">
        <property type="entry name" value="CYCLIN Y, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16746">
        <property type="entry name" value="BAR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16016">
        <property type="entry name" value="VASt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51778">
        <property type="entry name" value="VAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1172"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1201"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="358"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="VASt" evidence="8">
        <location>
            <begin position="924"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="682"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="851"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1129"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="892"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1129"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1141"/>
            <end position="1151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3302348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1438" mass="156991" checksum="31479E2146358BA5" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GMJ5</accession>
    <name>A0AAJ0GMJ5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_312799</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718472.1">
        <property type="nucleotide sequence ID" value="XM_062863950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GMJ5"/>
    <dbReference type="GeneID" id="87882779"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3302692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="188" mass="20825" checksum="E31D6A5DBECCA6C3" modified="2024-07-24" version="1">MPGSPPRSIRADRRRHPLPITRRGRTTKVIRDGLLLCLFLLPSRGGRSGSSRGSRIHIRILVRVIVSPVRLPVLVRDKRLLRLLLGTGGVLLLVVGHLGLPQAAEQGLEDVLQRVRLLFLCWLLLLLGGGRLLGGCLLWFLLLLLLLLWLLLFLSRLLLWLLLLQLGLGVGGHGCGLLGFGFSFRLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GMP4</accession>
    <name>A0AAJ0GMP4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Twinfilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0T15DRAFT_314456</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with G-actin; ADP-actin form.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cell cortex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718547.1">
        <property type="nucleotide sequence ID" value="XM_062863967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GMP4"/>
    <dbReference type="GeneID" id="87882796"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11284">
        <property type="entry name" value="ADF_Twf-C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11285">
        <property type="entry name" value="ADF_Twf-N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000042">
        <property type="entry name" value="Actin depolymerizing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000007">
        <property type="entry name" value="Twinfilin-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ADF-H"/>
    </dbReference>
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        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028458">
        <property type="entry name" value="Twinfilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13759">
        <property type="entry name" value="TWINFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13759:SF1">
        <property type="entry name" value="TWINFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ADF-H" evidence="12">
        <location>
            <begin position="3"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="ADF-H" evidence="12">
        <location>
            <begin position="175"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="302"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="314"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="325"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3302767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="334" mass="37109" checksum="93C046E109B41C50" modified="2024-07-24" version="1">MQSGISASQELVSQFNTLLGSDRHFGLLATIESEQLQPLKLLTPASPGGSFASNVESLLRPEIKPDEPLYVILRRYASAPALVAVTYVPDTAKVRQKMLFASTRLTLVRELGSEHFRDTFFATMSDELSPAGFEKHDAHAALEAPLTEEERSLGEVRRAEMEAGMGTATREIHLSSHMKTPIADDALEALKELAAEGRSLVMLKINPESESIELVPDQSAPSSIPELVQTISPSEPRFTFYRFTHTHDGSESSPLLFFYTCPSSFSTKAIKFRMMYPLMKRAVLSLAEKEAGLQPQKKFEVEDASEITEQGVMEELHPKTEVKRGFNRPKRPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GMU3</accession>
    <name>A0AAJ0GMU3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Concanavalin A-like lectin/glucanase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_258350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3302878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718658.1">
        <property type="nucleotide sequence ID" value="XM_062863285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GMU3"/>
    <dbReference type="GeneID" id="87882114"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02182">
        <property type="entry name" value="GH16_Strep_laminarinase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF60">
        <property type="entry name" value="GRAM-NEGATIVE BACTERIA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH16" evidence="1">
        <location>
            <begin position="26"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3302878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="271" mass="29604" checksum="D202DADB07C52480" modified="2024-07-24" version="1">MVALDSSVLVGLSVLARQSFNLVQNITFDGAPGQSVDTSQWNFITDLHVNNEVQQYTTSTDNLQLSGKGTVLVIPRKSADGKWTSGRIESKASFTPEDKKVTRFESVLRFGDAPKEKSQGIWPAFWMLGESSRQGVPWPECGELDIMERINGDAKGHGTPHCGKGDVPCGALTKTVPLGDNGFHTWALEVDRTDPDFNKQSINWFLDQTKYNTVTGADVKDEGIWKTIAHSPMYFILNIAVGGNFPGAPNDQTADGLSSMMEVKYIAVSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GMW6</accession>
    <name>A0AAJ0GMW6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_538595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3302931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718711.1">
        <property type="nucleotide sequence ID" value="XM_062869691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GMW6"/>
    <dbReference type="GeneID" id="87888520"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3302931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="203" mass="22627" checksum="F7E9780BE063A7F2" modified="2024-07-24" version="1">MTEPRGVILVLPEPDFDLSPIFSKVMHANSNSLLGSGSRKLSRYPRLSIFESTFSSREARIMSIAFMRRILYALLSPSSASAWDGFSVPSMTPLMLVELISACMAPFHRVPSFLRGQFAQIRFVPLLHLGVRRHFVRLDLVSGFAARDNGSLLGCELREREESRKSVDLRASCACQSLLLEERGYHDAENGCKNAPKHTQKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GNR8</accession>
    <name>A0AAJ0GNR8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_272007</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719139.1">
        <property type="nucleotide sequence ID" value="XM_062863475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GNR8"/>
    <dbReference type="GeneID" id="87882304"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF47">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="2">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3303359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="320" mass="33953" checksum="059AC0547FF1A17D" modified="2024-07-24" version="1">MAPHVPPSGVWCPAVTLFNPDTDTLDAPAQSLYYSYLGKQTGLAGLVILGTNAETFLLTREERKELLVLARKVLGPDFPIMAGVGGHSVRQVNEFVADAVEAGADYVLLLPPGYFKVANMGEVVEGFYAQVADAWAGKGVRIVVYNFPGVCGGVDLDSETIARLVRRHENIVGVKLTCGSVAKITRLAAEFPPERFAVFGGQSDFLIGGLAVGSAGCIAAFANVFPKTIVEVYNLYKAGKTLEALELHKKAALAEQATKTGGIAATKYAASVFTAPLAGVKDAESKMMPRRPYLPPGAEAKRKIREALAGVAEIEKSIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GP16</accession>
    <name>A0AAJ0GP16_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_496040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719269.1">
        <property type="nucleotide sequence ID" value="XM_062867147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GP16"/>
    <dbReference type="GeneID" id="87885976"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3970.10">
        <property type="entry name" value="BSD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005607">
        <property type="entry name" value="BSD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035925">
        <property type="entry name" value="BSD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051494">
        <property type="entry name" value="BSD_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16019:SF5">
        <property type="entry name" value="BSD DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16019">
        <property type="entry name" value="SYNAPSE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03909">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00751">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140383">
        <property type="entry name" value="BSD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50858">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BSD" evidence="2">
        <location>
            <begin position="242"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3303489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="422" mass="46534" checksum="4634CDC9E0336146" modified="2024-07-24" version="1">MDIAYDHILESSVAEEQRTTPAQQSSLNADLQDAYRTISSSAWGARIGGFFGSVVKQGEVVYREAQQELSAVGQDATRGFTDLRQSIINHTRSLSLNTSVPSAASSSNQATGEAGENAETTPTATKNLSSEDAIKESETVLSRLRDEAAKRLRDLQKAEDAADEALLRFGSNLRDFLRDAIKIAPPSSDQTENQSSTVLFESKDAHGKRVIHTSRFDAQLHVIHTSPDSFTKDGTGAEFEAWVKDFDIDKKTEDISSDLEKYPELRATMEKLVPDQVPYAEFWKRYYFLRHGIETAEARRRDLLKAASAEEEVGWDEDSSEEGSSDDDSEDEPEPEPEPRKAPEASRRPGSTDSSTTIHPPAAKQGLLKPSEPRKSNDEKSQADSDASYDVVGARSGVPSQAPNSPKDSRKDDDDSDEEDWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GPG5</accession>
    <name>A0AAJ0GPG5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_282738</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719494.1">
        <property type="nucleotide sequence ID" value="XM_062863601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GPG5"/>
    <dbReference type="GeneID" id="87882430"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3303714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="280" mass="30697" checksum="70CAA09F3006C7BF" modified="2024-07-24" version="1">MRDCVSPKPDGLSGTGRATAANDSNRPRTMHRITRTATRSLWKNSTRFVNTFLAVIGQRRRITSLLRQLWDFERPFPAGIEVLYNPPNAVVDIIFVHGLTGDRIKTWTAHGASEPWPKTLLPEKIPNARILTVGYDANVVGLFGAVSQNSIGNHAENLLSHVASKIDGKVKARVTFHTSPASVTALTLTLVEQSAGLLRLPQLGWSGLSRGSEPVSQESAFTPPRCPSIDPRHRFPRDTAFRGKSCYACDAFGLAPWDFQVGKRQDSGLPQRGFRSASGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GPL1</accession>
    <name>A0AAJ0GPL1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_541304</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719588.1">
        <property type="nucleotide sequence ID" value="XM_062869851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GPL1"/>
    <dbReference type="GeneID" id="87888680"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23513">
        <property type="entry name" value="INTEGRAL MEMBRANE EFFLUX PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23513:SF6">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY ASSOCIATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="22"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="422"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="470"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="516"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="516"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="548"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3303808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="560" mass="61944" checksum="7676EF507B3302E4" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQ82</accession>
    <name>A0AAJ0GQ82_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RAM signaling pathway protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_418052</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719912.1">
        <property type="nucleotide sequence ID" value="XM_062865501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQ82"/>
    <dbReference type="GeneID" id="87884330"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019487">
        <property type="entry name" value="RAM_signalling_pathway_SOG2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF54">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10428">
        <property type="entry name" value="SOG2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="258"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="394"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="488"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="400"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3304132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="972" mass="105873" checksum="B4244851874D98C7" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQJ2</accession>
    <name>A0AAJ0GQJ2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NUDIX hydrolase domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_236392</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720093.1">
        <property type="nucleotide sequence ID" value="XM_062863018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQJ2"/>
    <dbReference type="GeneID" id="87881847"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034431">
        <property type="term" value="F:bis(5'-adenosyl)-hexaphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034432">
        <property type="term" value="F:bis(5'-adenosyl)-pentaphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008486">
        <property type="term" value="F:diphosphoinositol-polyphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000298">
        <property type="term" value="F:endopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901911">
        <property type="term" value="P:adenosine 5'-(hexahydrogen pentaphosphate) catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901909">
        <property type="term" value="P:diadenosine hexaphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901907">
        <property type="term" value="P:diadenosine pentaphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071543">
        <property type="term" value="P:diphosphoinositol polyphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04666">
        <property type="entry name" value="NUDIX_DIPP2_like_Nudt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047198">
        <property type="entry name" value="DDP-like_NUDIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12629">
        <property type="entry name" value="DIPHOSPHOINOSITOL POLYPHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12629:SF0">
        <property type="entry name" value="DIPHOSPHOINOSITOL-POLYPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="6">
        <location>
            <begin position="26"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="96"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3304313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="182" mass="20812" checksum="92B965669D941FFB" modified="2024-07-24" version="1">MAASNSNGRSMESRVGRSNQRYNSKGERLVAGVVPLTEDKGHVMLIQSTRRKGWVLPKGGWETDEECHEAAAREAWEEAGILVQIDYDLGDIQELSPRKKTSSSSSSSSKGSSKDSKDGKESTKYKQRSLYRFFEVTVTSEEPDWPEREKRERKWFTFAEAKEMLKDRPELQTALERSTMKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQK5</accession>
    <name>A0AAJ0GQK5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Elongin-C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_229549</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Controls sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719870.1">
        <property type="nucleotide sequence ID" value="XM_062862931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQK5"/>
    <dbReference type="GeneID" id="87881760"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18321">
        <property type="entry name" value="BTB_POZ_EloC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000035">
        <property type="entry name" value="Elongin C transcription elongation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039948">
        <property type="entry name" value="ELC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20648">
        <property type="entry name" value="ELONGIN-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SKP1 component POZ" evidence="6">
        <location>
            <begin position="6"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00045385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3304090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="107" mass="12423" checksum="1F3DA6DD5BE57466" modified="2024-07-24" version="1">MADSKYITLVSRDGFEFVVLREAALVSPTIKGMLRSQFIEARTGRCCFPEIDGVILEKVVDYFHYWYRNRDKEEVPDMEIPVELCLELLMAANYLNLEPATGLRDWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GR22</accession>
    <name>A0AAJ0GR22_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_246337</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720354.1">
        <property type="nucleotide sequence ID" value="XM_062863128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GR22"/>
    <dbReference type="GeneID" id="87881957"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008318">
        <property type="term" value="F:protein prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF3">
        <property type="entry name" value="PROTEIN PRENYLTRANSFERASE ALPHA SUBUNIT REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3304574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="341" mass="37848" checksum="5E504ADCCF4B8504" modified="2024-07-24" version="1">MSRALDPDTAAFLRAGDPLAAYQTISKVLISPKDGLLEIEVLGKTHFLEEGQYVLQDGSAVAISKLGLVQAFMVARQFLKGHLDGTLPRPDTDVLAMTAVILLFDPEYLTAANTRKRLLQAQISSGSDVRARLETEKRFVDSLLTSRLHRHTKSPTLWSHRRWLVHMFVLLGLPVDVLGDIRDVVFVAGERHPRNYYAWCHARFLMGLKRGISHPSISAAVQAWCFQHHTDISGWSFLSFLLHQESGTNIEVGCTTFTNVLNLASSLRLANESLWVFLRTLAASRLVGDEQCAQLRAVQAAILETVATPADQAVLRAAVDWCEAYRRRSGPPLADGQLRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GRI9</accession>
    <name>A0AAJ0GRI9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Aspartic peptidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B0T15DRAFT_399909</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720355.1">
        <property type="nucleotide sequence ID" value="XM_062865032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GRI9"/>
    <dbReference type="GeneID" id="87883861"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000085">
        <property type="entry name" value="Aspartic-type endopeptidase (CtsD), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000060">
        <property type="entry name" value="Aspartic-type endopeptidase ctsD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF75">
        <property type="entry name" value="ENDOPEPTIDASE (CTSD), PUTATIVE (AFU_ORTHOLOGUE AFUA_4G07040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 13" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042513704" evidence="15">
        <location>
            <begin position="21"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="16">
        <location>
            <begin position="131"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="89"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="481"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="162"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK3304575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="535" mass="57203" checksum="FC4D0A392A16D1E9" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GRZ1</accession>
    <name>A0AAJ0GRZ1_9PEZI</name>
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        <submittedName>
            <fullName evidence="9">Glycosyltransferase family 2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_554855</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062870365.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87889194"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="GT2_HAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052427">
        <property type="entry name" value="Glycosyltrans_GT2/GT47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47844:SF1">
        <property type="entry name" value="EXOSTOSIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47844">
        <property type="entry name" value="SYNTHASE CPS1, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G02500)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glyco_tranf_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
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        <location>
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            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="378"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3305062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">Knr4/Smi1-like domain-containing protein</fullName>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="GeneID" id="87881278"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018958">
        <property type="entry name" value="Knr4/Smi1-like_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00860">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="342"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="521"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3305227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="545" mass="60235" checksum="AB47ADF70FCD1C67" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GSE7</accession>
    <name>A0AAJ0GSE7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_531771</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721041.1">
        <property type="nucleotide sequence ID" value="XM_062869275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GSE7"/>
    <dbReference type="GeneID" id="87888104"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097:SF9">
        <property type="entry name" value="EPIMERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G07320)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097">
        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3305261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="244" mass="26714" checksum="C140F9B8F723662A" modified="2024-07-24" version="1">MKLVVAGSTGFVATEVIRQALSNPSITSVVALGRRPAPEPQSTGSRADLTKLRSVTVDDLGEEYPDHVKKELSGADACIWTIAITPSKSKLFSWEQTIKVCRDYAIRGIETISQLVHESQKDKPFRFVYISGDRAERDPKKKPWILGDYCLMRGEAEERILEYAQRSDGAVEACTAKPGLISGPGKPATLVTQVFTSVIGLPRIQVSEIAAALLDQVVSGFEKDTLRNEDLVRIGQKTLAAQQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GSK7</accession>
    <name>A0AAJ0GSK7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SPX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_434095</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721131.1">
        <property type="nucleotide sequence ID" value="XM_062865792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GSK7"/>
    <dbReference type="GeneID" id="87884621"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14474">
        <property type="entry name" value="SPX_YDR089W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF1">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE COMPLEX SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="410"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="479"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="8">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="199"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="337"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3305351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="505" mass="56124" checksum="BBCF7404CABEED7A" modified="2024-07-24" version="1">MKYGEQFERESVPQWSLHNIDYNSLKHHIKAHTTKDQATAIAIPGRPNTALRKFEDDFYAELCRQHDRVDLFVTSKADEIARRIQHLSGQIHRLILRCATSGRDRIPLKRQSRFAKYEQTLLQCGDDIKALQRFVNAQIVAFRKILKKYRKWTGSSTLGSRFRDNVLSHPKSFTKRDFSQLHTQYMDLLGTLRAALPTNPDGRITMPSTEAQPSRPPTADLSPSETIVAPEPPPNVGYWNEYDYGSEAGDVDRNGDGEYAIYIDPNEDSSLAVIKGLAAFFATPFTKLSAWISPRTMKSGEDTERSALLHTHSTGSHYDYGSNRSVGEGSYFATPPGGRIGIGTETDGEDDLRSTAYPSNRHSRRTSVSNRDYTSCSDDQQFPSGYSAYRAAYVLPSIPDQRVARYRERVLLWGTLGCFAASFLLMAIATLLITTGRHKMRLEVDAGATLGIVASLGAACAGLCMTGSRRDKVSLLYRLAVWVAFAGSCVLNGVLLVMVMGNTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GSZ4</accession>
    <name>A0AAJ0GSZ4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">glucan endo-1,6-beta-glucosidase</fullName>
            <ecNumber evidence="8">3.2.1.75</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0T15DRAFT_202933</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Random hydrolysis of (1-&gt;6)-linkages in (1-&gt;6)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.75"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.75" evidence="8"/>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721367.1">
        <property type="nucleotide sequence ID" value="XM_062862592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GSZ4"/>
    <dbReference type="GeneID" id="87881421"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046557">
        <property type="term" value="F:glucan endo-1,6-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004348">
        <property type="term" value="F:glucosylceramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006680">
        <property type="term" value="P:glucosylceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000128">
        <property type="entry name" value="Endo-1,6-beta-D-glucanase neg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033452">
        <property type="entry name" value="GH30_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001139">
        <property type="entry name" value="Glyco_hydro_30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033453">
        <property type="entry name" value="Glyco_hydro_30_TIM-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069">
        <property type="entry name" value="GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069:SF23">
        <property type="entry name" value="LYSOSOMAL ACID GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02055">
        <property type="entry name" value="Glyco_hydro_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17189">
        <property type="entry name" value="Glyco_hydro_30C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00843">
        <property type="entry name" value="GLHYDRLASE30"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 9 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042585898" description="glucan endo-1,6-beta-glucosidase" evidence="10">
        <location>
            <begin position="17"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 30 TIM-barrel" evidence="11">
        <location>
            <begin position="72"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 30 beta sandwich" evidence="12">
        <location>
            <begin position="415"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00036633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3305587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="482" mass="51334" checksum="357C946616DB816D" modified="2024-07-24" version="1">MLSLALALLSLPAALGATLNARASPQAYASNKDGTYKLTPVGAPVRGAGNPGSGSTWKLSINDQPSGHKQTINGFGAAVTDATVAVFNKLPADKLTALLNQLMTDAGANFKLMRHTIASSDLSADPSYSYDDNGGTVDTALSGFNLGDRGTAMAKLLARMKSLQPDLTVVGSVWSPPGWMKLNGVLQGTTVNNNLNHAYASQYAQYFVKYLQAYRAQGVTVDAITIQNEPLNSQAGMPTMYIYADESGRLIQENVGPALRSAGFNTAIWAYDHNTDQPSYPQTVLNEASQYVNTVAWHCYAPNNDWGVLSDFHKANPSVDQYMTECWTSTQTGWSQAADFTMGPLQNWARGALAWTLATDTNQGPHLSGGSGPCTTCRGLVTVDVDAGTYAFQVDYYMMAQFSRFIPKGAVVLDGSGSYTYPGSGGIQSVATLNPDQTRTVVIENTFGNDVYVTLTTAKGETWSGNVVANSVVTWLLPASSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GT00</accession>
    <name>A0AAJ0GT00_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_493728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721356.1">
        <property type="nucleotide sequence ID" value="XM_062866966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GT00"/>
    <dbReference type="GeneID" id="87885795"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3305576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="190" mass="21711" checksum="D9B773C8A52A3753" modified="2024-07-24" version="1">MASTVTSGSLVYERRVVERIHKYHWPAVQLNLWMLIMLIASCLIIGVFATFIQIQNQLLLPIPWYFPYYITVASLTVTFIILLLWLIFQRRLLPSIVMIGGFILFVLWLTGLIVISIQLWGPDGSVNSNCDMYVFGADPQPTGQTLQTLAWLQQRNICQSWQAVFAFGLVGAIFLLWIMVMAYQVFADDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GT58</accession>
    <name>A0AAJ0GT58_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_398361</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721458.1">
        <property type="nucleotide sequence ID" value="XM_062864950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GT58"/>
    <dbReference type="GeneID" id="87883779"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF163">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="309"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="12"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3305678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="355" mass="39076" checksum="6D3BB193176751EE" modified="2024-07-24" version="1" fragment="single">PQHWRIWRKNTHVLFVNFMTFFIQFSAGMIVTSLPEIMSEFGAEDRLELSSYIVLAFVLGHLAEPLLITPLSRIYGRSVVSRVCNSGFVLSTLLCSYASSLATLIFFRSMAGIFGGGALSNGTYTMKDLKVLWGKTGLLHELSGLLGFILGPVCGGYISDGLGWRRTFALLAGAAAAVAISMVVVSRETYIPALLRQKVAHRRRETGNRHLRSALDSGLSPSQRLWRDIVRPFPVLFSNMLCTVYTCVGGIMYGLLYVMLTTIGLTLTRFYLLRTDGLGIYYLGLGGGCLLGWVSWLEFTKQAGVMEARLWPVFFSATVAMVGFGLCASTDNLANRYPESRVFVAILAMGGHIFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GTE3</accession>
    <name>A0AAJ0GTE3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine hydroxymethyltransferase</fullName>
            <ecNumber evidence="9">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_210292</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Interconversion of serine and glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="9"/>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721579.1">
        <property type="nucleotide sequence ID" value="XM_062862666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GTE3"/>
    <dbReference type="GeneID" id="87881495"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000097">
        <property type="entry name" value="Serine hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000586">
        <property type="entry name" value="PRK00011.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF28">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="7 8 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="10">
        <location>
            <begin position="26"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3305799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="487" mass="53760" checksum="7C7694106055AF93" modified="2024-07-24" version="1">MAANNTQGATYALPQTHKEMLEKSLVESDPEVAEIMKHEIQRQRESIILIASENVTSRAVFDALGSPMSNKYSEGYPGARYYGGNQHIDQIELLCQKRALEAFHLDGAKWGVNVQCLSGSPANLQVYQAIMPPHGRLMGLDLPHGGHLSHGYQTPQRKISAVSTYFETMPYRVNLDTGIIDYDELERNAQLFRPKILVAGTSAYCRLIDYERMRKIADSVGAYLVVDIAHISGLVAAEVIPSPFHYADVVTTTTHKSLRGPRGAMIFFRKGVRSVDAKTGKETLYDLEDKINFSVFPGHQGGPHNHTITALAVALKQAASPEFKEYQQKVVANAKALEKKFKELGHKLVSDGTDSHMVLLDLRPLSLDGARVEAVLEQINIACNKNSVPGDKSALTPGGLRIGTPAMTSRGFGEADFERVAVYIDESIKLCKEVQAALPKEANKLKDFKFKVASGEVSRINELKKEISDWCHTFPLPVEGWRMDAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GU62</accession>
    <name>A0AAJ0GU62_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_534100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3306025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721805.1">
        <property type="nucleotide sequence ID" value="XM_062869415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GU62"/>
    <dbReference type="GeneID" id="87888244"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042466670" description="Extracellular membrane protein CFEM domain-containing protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3306025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="189" mass="19670" checksum="B8A79EA44180D165" modified="2024-07-24" version="1">MLLVLTQPHLLLLLALTAGSNLAAAAQADDPVAMIKGMSQCQALCAVMASQPKTGCGVRFDCLCDGDGGKAWQGNVSDCFNANNFNFKDANAQQLSKRRCRDKPDAKDVKLTDLCKAYSPDKASDMVEAFKEKYPEVQDVSLRIAFGLKGPEAELSSDGAAAAGGGGARFGMVAAGMLAAVAGYAVAMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GUF4</accession>
    <name>A0AAJ0GUF4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_138605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722166.1">
        <property type="nucleotide sequence ID" value="XM_062861854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GUF4"/>
    <dbReference type="GeneID" id="87880683"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000069">
        <property type="entry name" value="HAD-superfamily subfamily IIA hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006353">
        <property type="entry name" value="HAD-SF_hydro_IIA_CECR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01456">
        <property type="entry name" value="CECR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF51">
        <property type="entry name" value="HYPOTHETICAL HAD-SUPERFAMILY HYDROLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3306386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="534" mass="59691" checksum="36BC6883D00530F9" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GUL9</accession>
    <name>A0AAJ0GUL9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_219141</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3306150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721930.1">
        <property type="nucleotide sequence ID" value="XM_062862789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GUL9"/>
    <dbReference type="GeneID" id="87881618"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF46">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="8"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3306150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="574" mass="64179" checksum="145565F91F3EAB99" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GUV2</accession>
    <name>A0AAJ0GUV2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase M20 dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_138842</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722180.1">
        <property type="nucleotide sequence ID" value="XM_062861859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GUV2"/>
    <dbReference type="GeneID" id="87880688"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000328">
        <property type="term" value="C:fungal-type vacuole lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05674">
        <property type="entry name" value="M20_yscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000085">
        <property type="entry name" value="Gly-Xaa carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017141">
        <property type="entry name" value="Pept_M20_carboxypep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047177">
        <property type="entry name" value="Pept_M20A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE/HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962:SF1">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE_HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037217">
        <property type="entry name" value="Carboxypeptidase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="9">
        <location>
            <begin position="290"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="574"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037217-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037217-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3306400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="604" mass="66169" checksum="A0650D64FBB47342" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GV03</accession>
    <name>A0AAJ0GV03_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_149593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722453.1">
        <property type="nucleotide sequence ID" value="XM_062861972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GV03"/>
    <dbReference type="GeneID" id="87880801"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3306673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="220" mass="24215" checksum="1AF428AF7C22E3CC" modified="2024-07-24" version="1">MAASVETSQYERDLRSARKEWKRTKDSAVKWSRGTRHLAGIRYNLQGDLVDGVTAPVCQLSKFRPEKKFSESHHLPKHTPNLVKMRSLHHTPLSRKAAKLHALSEIQAGDHGDASPASSPSLSRTLSASAAADAGVLYSFDRTDSPGVPLTLEVFVKKTTWRETEKLVEREYEVLDGNGEALRGRRARALLRRGGTTGEGGKEPGGDEEQGLEDDGFELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GV23</accession>
    <name>A0AAJ0GV23_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Thiamine-triphosphatase</fullName>
            <ecNumber evidence="6">3.6.1.28</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0T15DRAFT_143545</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Hydrolase highly specific for thiamine triphosphate (ThTP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>thiamine triphosphate + H2O = thiamine diphosphate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11744"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
            <dbReference type="ChEBI" id="CHEBI:58938"/>
            <dbReference type="EC" id="3.6.1.28"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ThTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.28" evidence="6"/>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722300.1">
        <property type="nucleotide sequence ID" value="XM_062861910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GV23"/>
    <dbReference type="GeneID" id="87880739"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050333">
        <property type="term" value="F:thiamine triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042357">
        <property type="term" value="P:thiamine diphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006772">
        <property type="term" value="P:thiamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07758">
        <property type="entry name" value="ThTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.320.10">
        <property type="entry name" value="Hypothetical Protein Pfu-838710-001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023577">
        <property type="entry name" value="CYTH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039582">
        <property type="entry name" value="THTPA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012177">
        <property type="entry name" value="ThTPase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14586">
        <property type="entry name" value="THIAMINE-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14586:SF1">
        <property type="entry name" value="THIAMINE-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01928">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="CYTH-like phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYTH" evidence="14">
        <location>
            <begin position="80"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00020088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3306520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="260" mass="29796" checksum="92282474F346D17E" modified="2024-07-24" version="1">MALRATRTLLMRVTQPPSPARQTKPRPTTILEVERKFRRLAVPTLTDICTTTTTKNHSNRYCYKYNPNPNFRSVVPLPTRTIHDIYYDTPDHTLCTSGGAWIRRRNGEWQAKLKRGGDFVNSRFEELRGAREIGNCIRSILGGVSSGGGVVVFQHEGENNFGLEKLAEFVTTREAWLVDGEFKVVRDRMDFGHEVGEVELQVEVPIDEAEKERGAVMMEEMDRRIEGFMKRYAWVWETGEAVGKLTAYFEMMMREKNGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GV31</accession>
    <name>A0AAJ0GV31_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_150781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722496.1">
        <property type="nucleotide sequence ID" value="XM_062861990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GV31"/>
    <dbReference type="GeneID" id="87880819"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05120">
        <property type="entry name" value="APH_ChoK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF55">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="66"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3306716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="181" mass="20488" checksum="FCB80D518353FF82" modified="2024-07-24" version="1">MMEPSLAINDSTARRFLSLAVIKVRRGFLICRAAIAMDRHILDRYPKYIRISKHLFLKTGRDVHLTEAATLRFVAEKTSIPVPRVHCAFAHDNRGIIVMERVPGVTLARAWKSLSAADRDAIFEQLRSMINELRSLPPGPGVGIESCVGGSLTDPRLERANPRFGPFKTTQEFHLWLHYDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GVJ0</accession>
    <name>A0AAJ0GVJ0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mitochondrial import receptor subunit TOM20</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Mitochondrial 20 kDa outer membrane protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Mitochondrial import receptor subunit tom20</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Translocase of outer membrane 20 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0T15DRAFT_395969</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the Tom20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722647.1">
        <property type="nucleotide sequence ID" value="XM_062864805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GVJ0"/>
    <dbReference type="GeneID" id="87883634"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005742">
        <property type="term" value="C:mitochondrial outer membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016031">
        <property type="term" value="P:tRNA import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.960.10:FF:000002">
        <property type="entry name" value="Mitochondrial import receptor subunit TOM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.10">
        <property type="entry name" value="Mitochondrial outer membrane translocase complex, subunit Tom20 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002056">
        <property type="entry name" value="MAS20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023392">
        <property type="entry name" value="Tom20_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00985">
        <property type="entry name" value="3a0801s04tom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12430">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12430:SF0">
        <property type="entry name" value="TRANSLOCASE OF OUTER MITOCHONDRIAL MEMBRANE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02064">
        <property type="entry name" value="MAS20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037707">
        <property type="entry name" value="MAS20_rcpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00351">
        <property type="entry name" value="OM20RECEPTOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47157">
        <property type="entry name" value="Mitochondrial import receptor subunit Tom20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 14" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="41"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR037707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3306867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="185" mass="20133" checksum="465CD157F54A915F" modified="2024-07-24" version="1">MSTTSRTAVVATATVAAVAAGVLAYAAYFDYRRRHSPEFRRQLRRSQRRQARAEKDQAEANLQAQRQAIRQAVDEAKEEGFPASAEEKEAYFLEQVQAGEIMGADPSKALDAALAFYKALKVYPTPGDLINIYDKTVSKPILDILAEMIAYDGSLRIGTSYTGPAGVDVAELMREMGAVPGVGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GW01</accession>
    <name>A0AAJ0GW01_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_166371</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722941.1">
        <property type="nucleotide sequence ID" value="XM_062862167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GW01"/>
    <dbReference type="GeneID" id="87880996"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3307161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="87" mass="9210" checksum="0E4D6B51B4334716" modified="2024-07-24" version="1">MAALESAIRHLHSLGVAHNGNVMVNAEGIPVLIDFGSSRAIGKKLGPSRGTAGWIEGDPSDYDTSDDGHDLYALEKIRAWLDNPAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GX65</accession>
    <name>A0AAJ0GX65_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_374495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3307737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723517.1">
        <property type="nucleotide sequence ID" value="XM_062864219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GX65"/>
    <dbReference type="GeneID" id="87883048"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3307737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="287" mass="32024" checksum="D4F986E28C35F773" modified="2024-07-24" version="1" fragment="single">PAMDGGLFVDIYTLYGIWLDTPRGPAMLPSDNCLPLDYLLKQELSRWESGRYVYDSSVEEGLRVQKWVPIPATIEGAVAYFPNLQVVEAISEWERLLCAIESKMPSSSIRTPEGENSERERGEPKFAKHFLSRARRPMGWTFVAPGIGTFTNESLCEAYATEAEDTFRRIFTTSEEGEDWVTLLLPSLSGDKRPVTVPTDPFGFGKATVGRRAGLYTSWADEWDGDLVQLVCPSGRQNAGVFSGPCPWGPSRMPRLAELLGHWANLVEDGAWCIDADGVEEDAMWFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GX76</accession>
    <name>A0AAJ0GX76_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Armadillo-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_86037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3307826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723606.1">
        <property type="nucleotide sequence ID" value="XM_062871396.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87890225"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056251">
        <property type="entry name" value="Arm_rpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055496">
        <property type="entry name" value="DUF7068"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312:SF2">
        <property type="entry name" value="NUCLEOTIDE-BINDING OLIGOMERIZATION DOMAIN-CONTAINING PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23948">
        <property type="entry name" value="ARM_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23238">
        <property type="entry name" value="DUF7068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NACHT" evidence="1">
        <location>
            <begin position="522"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3307826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1579" mass="175952" checksum="B5376B16D1CA8C33" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GXW1</accession>
    <name>A0AAJ0GXW1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable methionine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="2">6.1.1.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0T15DRAFT_523612</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(Met) + L-methionine + ATP = L-methionyl-tRNA(Met) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="2"/>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723909.1">
        <property type="nucleotide sequence ID" value="XM_062868704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GXW1"/>
    <dbReference type="GeneID" id="87887533"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.220.10:FF:000001">
        <property type="entry name" value="methionine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023457">
        <property type="entry name" value="Met-tRNA_synth_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326:SF1">
        <property type="entry name" value="METHIONINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326">
        <property type="entry name" value="METHIONYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19303">
        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="11">
        <location>
            <begin position="55"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl-tRNA synthetase anticodon-binding" evidence="12">
        <location>
            <begin position="477"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF19303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3308129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="620" mass="70604" checksum="9C44CD10FA66A4B5" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GXW6</accession>
    <name>A0AAJ0GXW6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Clathrin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_572417</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasmic vesicle membrane</location>
            <topology evidence="1 6">Peripheral membrane protein</topology>
            <orientation evidence="1 6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <location evidence="6">Coated pit</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="6">Cytoplasmic face of coated pits and vesicles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the clathrin light chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723981.1">
        <property type="nucleotide sequence ID" value="XM_062870891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GXW6"/>
    <dbReference type="GeneID" id="87889720"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030132">
        <property type="term" value="C:clathrin coat of coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032050">
        <property type="term" value="F:clathrin heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000996">
        <property type="entry name" value="Clathrin_L-chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10639">
        <property type="entry name" value="CLATHRIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10639:SF7">
        <property type="entry name" value="CLATHRIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01086">
        <property type="entry name" value="Clathrin_lg_ch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0168">Coated pit</keyword>
    <keyword evidence="5 6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="55"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3308201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="236" mass="25728" checksum="FF0974D126288416" modified="2024-07-24" version="1">MADRFPSLEDFDSGAQTDIKDTSDVPSASNFLEREKAILGEDANQFATVEDAGIDDADNDLLGGGVSSAGGNAAFESQFPDITSPNAGVTSSGPITGPSVSYNSGYQPYTEEEEEPEVIKEWREKRDAQIAKRAEQFAQQRAETIREAQQNIDDFYENYNNKKEKMIAQTRKEAEQFLASREDTTSGGTSWERISKLVDVSGKGAKGGAAGSGKERFRELLMSLRKDEKAPGAEGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GXX2</accession>
    <name>A0AAJ0GXX2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_391454</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3307765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723545.1">
        <property type="nucleotide sequence ID" value="XM_062864591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GXX2"/>
    <dbReference type="GeneID" id="87883420"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="70"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3307765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="648" mass="72482" checksum="C5F4CF1D3480E549" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GY50</accession>
    <name>A0AAJ0GY50_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_87748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3307885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723665.1">
        <property type="nucleotide sequence ID" value="XM_062871415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GY50"/>
    <dbReference type="GeneID" id="87890244"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="423"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="471"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="544"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3307885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="593" mass="65207" checksum="F37A955A6B2AA920" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GYG4</accession>
    <name>A0AAJ0GYG4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mss4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_508947</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724268.1">
        <property type="nucleotide sequence ID" value="XM_062867758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GYG4"/>
    <dbReference type="GeneID" id="87886587"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF40">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="5"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3308488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="137" mass="15764" checksum="82860B7A800AED4E" modified="2024-07-24" version="1">MAIHMQGRCVCEKLQYSLQLDTPDDARTTLCHCRSCRRAFGTNYGLTAKVPVQAFKYESGCPKTYKQKNGVTREFCDSCGAYICEYGEEAADKFRYIMWGSLDEPEKIPPKGEFFCKNRPAWMPEIPGLFHKKEIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GYG7</accession>
    <name>A0AAJ0GYG7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Domain of Kin17 curved DNA-binding protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_523784</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KIN17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723985.1">
        <property type="nucleotide sequence ID" value="XM_062868722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GYG7"/>
    <dbReference type="GeneID" id="87887551"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2030:FF:000001">
        <property type="entry name" value="DNA/RNA-binding protein KIN17, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2030">
        <property type="entry name" value="DNA/RNA-binding protein Kin17, conserved domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056767">
        <property type="entry name" value="C2H2-Znf_KIN17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019447">
        <property type="entry name" value="DNA/RNA-bd_Kin17_WH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037321">
        <property type="entry name" value="KIN17-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038254">
        <property type="entry name" value="KIN17_WH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12805:SF0">
        <property type="entry name" value="DNA_RNA-BINDING PROTEIN KIN17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12805">
        <property type="entry name" value="KIN17 KIN, ANTIGENIC DETERMINANT OF RECA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25095">
        <property type="entry name" value="C2H2-zf_KIN17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10357">
        <property type="entry name" value="WH_KIN17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01253">
        <property type="entry name" value="Kin17_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="153"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="180"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="295"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3308205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="318" mass="36167" checksum="BEACF962860A8D3F" modified="2024-07-24" version="1">MGKAEPGSTKYLSNKMKQKGLTRLRWYCQICEKACRDENAFKMHCQSESHMRRALEAGQNFKSVQEDYSKQFLHEFISLLKTAHGEKSIHANKFYQEVIAKKDHTHLNATKWHSLTDFVKYIAREGIVRAEEKEDGLFIAWIDDSPEAMKRREAVRRKEMQDKGDEEREQMIWGEEEDEEKGKELKREEGEKIKLSFGTKTTGKSTTPEVATRSPSAGAEGSGSDLTKRTSNGETKKEEEEEAKPGEVTAAVKPVSLKFGAKPQPKNVFKNAFAGAPKKVMAAQPKKMSEAERIMKEELERKRAREAGGGPPQKRPRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GYW7</accession>
    <name>A0AAJ0GYW7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_525072</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724491.1">
        <property type="nucleotide sequence ID" value="XM_062868818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GYW7"/>
    <dbReference type="GeneID" id="87887647"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF24">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHETASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G11920)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="2">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3308711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="327" mass="34946" checksum="C0B2CB71E677571B" modified="2024-07-24" version="1">MTLANGAPNGSGTTRRPLPCGIYAPTMTFFDPETEDLDIPTIKKHAERLVRDGLVGLVTMGSNGEAIHCTREEKLAVTQATREALDAAGFPDTPIIIGATEGSVRGTIELCKLAQKAGADYALILPPSYFRFLMNEEAIHDYFVAVANESPLPLILYNYPGAVAGIDMDSDLLIRLASHPNIVGTKFTCGNTGKLTRVALATDAKTPWSEGSGYMAFGGICDFTVQTLASGGSGIIAGGANVMPKLCVKVWNLYAEGKKDEAIALQKTLSKGDWVLTKAAIAGTKQAIHSYFGYGGYPRRPLKRLDKASVATIEEGVREVMELEKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GZ16</accession>
    <name>A0AAJ0GZ16_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent RNA helicase DED1</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP-dependent RNA helicase ded1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">B0T15DRAFT_390704</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724519.1">
        <property type="nucleotide sequence ID" value="XM_062864552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GZ16"/>
    <dbReference type="GeneID" id="87883381"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17967">
        <property type="entry name" value="DEADc_DDX3_DDX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000160">
        <property type="entry name" value="ATP-dependent RNA helicase DDX3X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044763">
        <property type="entry name" value="Ded1/Dbp1_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 15 20" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="19">
        <location>
            <begin position="183"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="214"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="415"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="81"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="575"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="613"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="14">
        <location>
            <begin position="183"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="109"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="580"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAK3308739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="669" mass="70706" checksum="38C640CD85468BAD" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GZD3</accession>
    <name>A0AAJ0GZD3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">SMC hinge domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0T15DRAFT_122764</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724699.1">
        <property type="nucleotide sequence ID" value="XM_062861649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GZD3"/>
    <dbReference type="GeneID" id="87880478"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03275">
        <property type="entry name" value="ABC_SMC1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028468">
        <property type="entry name" value="Smc1_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937:SF12">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="12">
        <location>
            <begin position="276"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="185"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="427"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="766"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3308919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="987" mass="113247" checksum="36CE1CF7CE86C803" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H041</accession>
    <name>A0AAJ0H041_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_515318</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
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    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="protein sequence ID" value="KAK3309366.1"/>
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        <property type="nucleotide sequence ID" value="XM_062868180.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
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        <property type="match status" value="1"/>
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            <dbReference type="EMBL" id="KAK3309366.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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        <name evidence="8" type="ORF">B0T15DRAFT_516122</name>
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    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
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        <subcellularLocation>
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        </subcellularLocation>
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        <text evidence="6">Belongs to the BRMS1 family.</text>
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    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_062868236.1"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="BREAST CANCER METASTASIS-SUPPRESSOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Sds3"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038256"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3309658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="681" mass="75773" checksum="7667CC4372041C02" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H0R3</accession>
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        <submittedName>
            <fullName evidence="8">Cullin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_388176</name>
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    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
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            <taxon>Sordariomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725491.1">
        <property type="nucleotide sequence ID" value="XM_062864431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H0R3"/>
    <dbReference type="GeneID" id="87883260"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000014">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000001">
        <property type="entry name" value="Cullin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000002">
        <property type="entry name" value="cullin-3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000061">
        <property type="entry name" value="Related to cullulin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000036">
        <property type="entry name" value="SCF ubiquitin ligase subunit CulC, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.130:FF:000011">
        <property type="entry name" value="SCF ubiquitin ligase subunit CulC, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Cullin family profile" evidence="7">
        <location>
            <begin position="432"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3309711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="820" mass="93802" checksum="259801D4A8F03440" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H0R4</accession>
    <name>A0AAJ0H0R4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_481298</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725483.1">
        <property type="nucleotide sequence ID" value="XM_062866015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H0R4"/>
    <dbReference type="GeneID" id="87884844"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021829">
        <property type="entry name" value="DUF3419"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47473">
        <property type="entry name" value="BTA1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47473:SF1">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11899">
        <property type="entry name" value="DUF3419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3309703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="711" mass="79769" checksum="160964B2B5A658BA" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H1D7</accession>
    <name>A0AAJ0H1D7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fibroin-3 related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_20607</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725778.1">
        <property type="nucleotide sequence ID" value="XM_062862623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H1D7"/>
    <dbReference type="GeneID" id="87881452"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037504">
        <property type="entry name" value="PSI_induc_2"/>
    </dbReference>
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        <property type="entry name" value="[PSI+] INDUCTION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="[PSI+] INDUCTION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="242"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="424"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3309998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="518" mass="54501" checksum="B38D7CD3686AEEB8" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H1M8</accession>
    <name>A0AAJ0H1M8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Sulfate transporter family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0T15DRAFT_488878</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062866551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H1M8"/>
    <dbReference type="GeneID" id="87885380"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034490">
        <property type="term" value="P:basic amino acid transmembrane import into vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000141">
        <property type="entry name" value="Sulfate transporter family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.750.24:FF:000012">
        <property type="entry name" value="Sulfate transporter family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052706">
        <property type="entry name" value="Membrane-Transporter-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43310:SF4">
        <property type="entry name" value="AFR304WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43310">
        <property type="entry name" value="SULFATE TRANSPORTER YBAR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="404"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="438"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="480"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="514"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="566"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="648"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="674"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="705"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="11">
        <location>
            <begin position="774"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="10">
        <location>
            <begin position="990"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="112"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="898"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3310191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1111" mass="122123" checksum="FB8BDFC444AD82EB" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H208</accession>
    <name>A0AAJ0H208_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0T15DRAFT_506790</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
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        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="JAUDZG010000001">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:phosphorelay sensor kinase activity"/>
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    </dbReference>
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        <property type="term" value="P:cellular hyperosmotic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
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    </dbReference>
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        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
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    </dbReference>
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        <property type="entry name" value="Two-component osmosensing histidine kinase"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
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    </dbReference>
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        <property type="entry name" value="Methyl-accepting chemotaxis protein (MCP) signaling domain"/>
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    </dbReference>
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        <property type="match status" value="6"/>
    </dbReference>
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        <property type="entry name" value="HIS_KIN"/>
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        <property type="entry name" value="RESPONSE_REGULATORY"/>
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    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0902">Two-component regulatory system</keyword>
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        <location>
            <begin position="173"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="15">
        <location>
            <begin position="268"/>
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    </feature>
    <feature type="domain" description="HAMP" evidence="15">
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            <begin position="360"/>
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    </feature>
    <feature type="domain" description="HAMP" evidence="15">
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    <feature type="domain" description="HAMP" evidence="15">
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    <feature type="domain" description="HAMP" evidence="15">
        <location>
            <begin position="636"/>
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        <location>
            <begin position="710"/>
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    <feature type="domain" description="Response regulatory" evidence="14">
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            <begin position="1082"/>
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    </feature>
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    <feature type="coiled-coil region" evidence="11">
        <location>
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            <position position="1131"/>
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    <evidence type="ECO:0000256" key="1">
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1291" mass="141268" checksum="F8FDE76E33B8259A" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H243</accession>
    <name>A0AAJ0H243_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Spc7 kinetochore protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_564435</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAK3310438.1"/>
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        <property type="nucleotide sequence ID" value="XM_062870640.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87889469"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990758">
        <property type="term" value="P:mitotic sister chromatid biorientation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040850">
        <property type="entry name" value="Knl1_RWD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033338">
        <property type="entry name" value="Spc105/Spc7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013253">
        <property type="entry name" value="Spc7_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28260">
        <property type="entry name" value="SPINDLE POLE BODY COMPONENT SPC105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28260:SF1">
        <property type="entry name" value="SPINDLE POLE BODY COMPONENT SPC105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18210">
        <property type="entry name" value="Knl1_RWD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15402">
        <property type="entry name" value="MELT_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08317">
        <property type="entry name" value="Spc7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00787">
        <property type="entry name" value="Spc7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01315">
        <property type="entry name" value="Spc7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spc7 kinetochore protein" evidence="3">
        <location>
            <begin position="905"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="89"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="326"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="551"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="759"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="808"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1084"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="117"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="177"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="278"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="332"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="571"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="621"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="654"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="759"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="813"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="840"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="874"/>
            <end position="892"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3310438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1419" mass="156200" checksum="2E4607C31EE2C04C" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H2Q0</accession>
    <name>A0AAJ0H2Q0_9PEZI</name>
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        <recommendedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">B0T15DRAFT_489391</name>
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    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062866595.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87885424"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
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        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053185">
        <property type="entry name" value="SET_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332:SF4">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SET"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3310734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="328" mass="35732" checksum="473C435055B1EDF7" modified="2024-07-24" version="1">MSSSGFAKESLNAAAISVETQDSSVLNGICSDGSGQHDVATLALTLTNGNVVTEISSPRIVSSKQESSRQESSKQESLENEPDAADGSNEEPDLIGVSEPIAVSTLECSGLATPPMDVTLGEQDKRGPELEDGNCPSRTLPLLVDKTTKTDFEAFFRIQPSELGGLGAFAVRELKKGETILVERPLLRTTHFRLMVDYHNLSEAAKKTYLGLHGGGGDPFNRVERIKNLNSFVVPGGIAIFEIASRFNHACRLARNVDYKFDDEQGVLSLTISQDVVPAGSELFINYGGSPLDLYWTYGFRCRCGGCTPLTDEDIRRLKEQEYGIFKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H2U3</accession>
    <name>A0AAJ0H2U3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CNH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_50299</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAK3310796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726576.1">
        <property type="nucleotide sequence ID" value="XM_062867454.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87886283"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041675">
        <property type="entry name" value="PH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057283">
        <property type="entry name" value="RGF3_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052233">
        <property type="entry name" value="Rho-type_GEFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572:SF1">
        <property type="entry name" value="RHO1 GUANINE NUCLEOTIDE EXCHANGE FACTOR TUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15405">
        <property type="entry name" value="PH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23582">
        <property type="entry name" value="WHD_RGF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="5">
        <location>
            <begin position="932"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="1159"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="6">
        <location>
            <begin position="1391"/>
            <end position="1700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="205"/>
            <end position="247"/>
        </location>
    </feature>
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        </location>
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            <begin position="1"/>
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        </location>
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            <begin position="14"/>
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            <begin position="208"/>
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        </location>
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        </location>
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        </location>
    </feature>
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    </feature>
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        </location>
    </feature>
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        </location>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3310796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1759" mass="193321" checksum="2CB0F5B8537FAC78" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H2U7</accession>
    <name>A0AAJ0H2U7_9PEZI</name>
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        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_489192</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
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            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CENP-K/MCM22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062866574.1"/>
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    <dbReference type="GeneID" id="87885403"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CENTROMERE PROTEIN K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11802">
        <property type="entry name" value="CENP-K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
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    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3310514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="328" mass="36907" checksum="F66AE38F1E88E787" modified="2024-07-24" version="1">MEAVRHSVSGPYEAELERTVQELKRMKRQLEDAVHQARLSAAASRAGLSAKDSLATMAKAYQGMTDAPPLLPPPGSVLPALLAMRRTQQTIAETNESTESYATLMEQLERKIEAERSALREQQTLEVALQNRIKSLSEGLENRQEKTEEQMAKERIAELRQQKDHWDKQTASLMKHLDWFISEHLGPMLAAEELGGPVVGELMDIDTDDLGAGFSAHGKLKKTKDQPDLDKRQRRIDDIWGPQDQQAQINKRKRDRDEASAASAEMRDLTEQLMNKLTEAAGDNTAAYVEIARESAAARFLVRSKVAVFHPKDARRLRLVDFGRELDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ0H2X8_9PEZI</name>
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        <recommendedName>
            <fullName evidence="5">Vezatin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B0T15DRAFT_518701</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Adherens junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the vezatin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726290.1">
        <property type="nucleotide sequence ID" value="XM_062868387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H2X8"/>
    <dbReference type="GeneID" id="87887216"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017022">
        <property type="term" value="F:myosin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026859">
        <property type="entry name" value="Myosin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026858">
        <property type="entry name" value="Vezatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15989">
        <property type="entry name" value="VEZATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15989:SF5">
        <property type="entry name" value="VEZATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12632">
        <property type="entry name" value="Vezatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0965">Cell junction</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin-binding" evidence="16">
        <location>
            <begin position="152"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="15"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="504"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="417"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF12632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK3310510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="612" mass="68398" checksum="382B0D35200EBFD0" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H3G8</accession>
    <name>A0AAJ0H3G8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_387562</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726639.1">
        <property type="nucleotide sequence ID" value="XM_062864391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H3G8"/>
    <dbReference type="GeneID" id="87883220"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="59"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="119"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3310859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="463" mass="50967" checksum="B67FA8E9AD8AB766" modified="2024-07-24" version="1">MAQTQDVAGGSTVSDAETRSKKRSRAETDVTDASAPATPSATEPSGDIVGSHITETGGSSVSANASSSSVSNPEPPLSESYPPSESKPSLSTGPSGSITPPYVFSGPHPAPQSLTGPTDEVEDETDQDALEEQAAAEQAEEGSIVVDSDDLGTDDGYGTDTNTTASTSLAESVRDYIYENGRRYHRFREGRYSFPNDDVEQQREDMKHSMVKLLCGQLYFAPIGEQPHEILDIGTGTGIWAIEMGDLFPNANILGVDLSPIQPEWVPPNVRFMVDDIDWLHPRNYFDYVHSRHTVMAIKDWPKLIRRALEHLRPGGWFELQEVYHFPISANKTMAPDHPVAQYWSLINEGLSNLGVTFHAVANGRLADMMRDCGFVNVTERVLHIPIGTWPKNKVLKTVGLYWRTILIDGIQAIALGPMTRGCGWTREQVELFLVDVRKAYFDNSVLAYMPLHIIYGQKPVGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H3L4</accession>
    <name>A0AAJ0H3L4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome c oxidase assembly protein COX16, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Cytochrome c oxidase assembly protein cox16, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0T15DRAFT_55116</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. May participate in merging the COX1 and COX2 assembly lines.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the COX16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726685.1">
        <property type="nucleotide sequence ID" value="XM_062870267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H3L4"/>
    <dbReference type="GeneID" id="87889096"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020164">
        <property type="entry name" value="Cyt_c_Oxase_assmbl_COX16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17130:SF14">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX16 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17130">
        <property type="entry name" value="MITOCHONDRIAL OUTER MEMBRANE PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14138">
        <property type="entry name" value="COX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3310905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="115" mass="13416" checksum="A2E9445782DFB760" modified="2024-07-24" version="1">MTVFQSRKYPSASHGNTLGARYRAMMAKHPFLLFGLPFLTVIVGASFVLTPATAIRYERYDRKVRQMTREEELGVGKDRRKVNIRDEYYRLAAKDLDNWEQKRVKRLPGEHDGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H3P1</accession>
    <name>A0AAJ0H3P1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_56830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726730.1">
        <property type="nucleotide sequence ID" value="XM_062870755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H3P1"/>
    <dbReference type="GeneID" id="87889584"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3310950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="89" mass="10196" checksum="9602D797CBBC4F7C" modified="2024-07-24" version="1">MTGKVIQATPSLMDSQTSYADRSWTMSFVEAAQRERRRREEHTTDVQQSILAYRLAAERKIEDAFRVNLFVPSSGRPTTLPARPKTKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ0H4J4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_83336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727487.1">
        <property type="nucleotide sequence ID" value="XM_062871368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H4J4"/>
    <dbReference type="GeneID" id="87890197"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="96"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3311707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="231" mass="25540" checksum="CFCA240D65A6EA8E" modified="2024-07-24" version="1">MPLEIRPAVEADSDRIGWIGRDAFRDSGSEAVFPPHLYDKSETGDIALDEAQWRAARNLARMREGKPTFVCVDVAEDDSNDTGGPERIIGYAQWEVPLPPVAGETGEAKKSGYYNQEPFPPSLDQDALFKIYKTVEDETKRALGPDGHSKMWYLMSLAVDPTQQRRGIGRKLMHHGLDLASQAGMDVFLLATPAGRGLYESLGFRQIGDSFLLADIPHYAMLWRRSGAGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H4Q6</accession>
    <name>A0AAJ0H4Q6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Kinesin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_482546</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727329.1">
        <property type="nucleotide sequence ID" value="XM_062866113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H4Q6"/>
    <dbReference type="GeneID" id="87884942"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3311549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="171" mass="18938" checksum="BDE87C115C3FC506" modified="2024-07-24" version="1">MQVIETYETKFGTDHPNTLKSIGNLASTYQNQGRWSEAEELELGPDYPDILTSMANLALTLCNQDRLEEAEELFVQAIETCKTKFGADHIETLASIYSLALIYSDQGRWLEPEELGVQVTETCKAKLGSDHPDTLRSTANLADCAQARQRVLPAEHPDTLSSLAAVAYWSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LXV4</accession>
    <name>A0AAJ0LXV4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_570007</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717506.1">
        <property type="nucleotide sequence ID" value="XM_062870824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LXV4"/>
    <dbReference type="GeneID" id="87889653"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="23"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3301726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="275" mass="31189" checksum="6B303A67F53F97F0" modified="2024-07-24" version="1">MRLLKTRDLEFEEFANDEHRPPYAILSHTWGPDEVTFAHRVGRQDPAKAGYAKIHGCCKIAESEGFQYVWIDSCCIDKSSSAELSEAINSMFQWYRDAAICYAYLSDVRVLEDPAGEMPAFSASRWFTRGWTLQELLAPTELVFFASDWTEIGTKSSLARTVSRITRIDEKILKGGDWSGYSVAQKMSWAAGRQTTRPEDEAYCLMGLFDVNMPLLYGEGRKAFLRLQQEILRVSEDQSMFAWSCDNTEELTRSEMTGGWVNTTPVSPRPPIDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LY29</accession>
    <name>A0AAJ0LY29_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-phytase</fullName>
            <ecNumber evidence="2">3.1.3.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_287850</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.8" evidence="2"/>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3301967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717747.1">
        <property type="nucleotide sequence ID" value="XM_062863667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LY29"/>
    <dbReference type="GeneID" id="87882496"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016158">
        <property type="term" value="F:inositol hexakisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF110">
        <property type="entry name" value="2-PHOSPHOXYLOSE PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3301967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="511" mass="56821" checksum="29B68EACA316ECD9" modified="2024-07-24" version="1">MTSLVPRKPYTDDELRKLYPDSLELQLVQILMRHGERTPISARFQNAGLTPWWPYCSSARHMRSAVLAAADTTTDHPFDTMKWKRRLETFGPNDEPVVARGPKGETDDICDLGSLTDLGRQSTYKLGLRLRQLYIDRLGFLPPTISSADFLYLRSTPVPRALESLQQTFSALYPPSTRNPGPDGKFPAPTILSRVPGDETLYPNDGNCRRFAALANAFAQRAADRWNNTSDMEYLQKIYGKWMPNGNKVAVDSHPRLSGIMDTVNATLAHGPETKLPKEFYDGKARDIMDKVVVEEWFAGYVESKEFRTLGIGGLLGDIVGRMVGSVEQQTGTGGPDSLLKRTGQEDHSATIRFGLSGCHDTTLAGVLASLGAYGMDRWPPFTSHVAIELFRESKIPPPEAEPAKKSWWTSLFAAAGGPTNIGRRPTTELTAAEKNKLDGYYVRIRYNDEPVTVPACRLPGNHLKGDESFCTLAAFKAVVDKFTPTDWKQQCRMNRDQPTLPTGEPEWAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LY59</accession>
    <name>A0AAJ0LY59_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0T15DRAFT_287906</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3301970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717750.1">
        <property type="nucleotide sequence ID" value="XM_062863669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LY59"/>
    <dbReference type="GeneID" id="87882498"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01874">
        <property type="entry name" value="Cdc42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000236">
        <property type="entry name" value="Cell division control protein 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037874">
        <property type="entry name" value="Cdc42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3301970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="194" mass="21722" checksum="F70A4489906D36CC" modified="2024-07-24" version="1">MRCCLGCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGDEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVTSPASFENVREKWFPEVHHHCPGVPCLIVGTQVDLREDQQVVAKLAKQKMKPVQREDGERMARELGAVKYVECSALTQYKLKDVFDEAIVAALEPPPPKKTKSHRCQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LYQ6</accession>
    <name>A0AAJ0LYQ6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_543515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718422.1">
        <property type="nucleotide sequence ID" value="XM_062869998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LYQ6"/>
    <dbReference type="GeneID" id="87888827"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042498250" evidence="2">
        <location>
            <begin position="34"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3302642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="77" mass="8470" checksum="EFC3C8BC72027FB9" modified="2024-07-24" version="1">MAIPTTARSTSDYRSPSLFLFSFFHSLLFLSLSENHSSPISSNQHQILIQVTPPEINQIPCRHGTTSPDPGMGEKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZ67</accession>
    <name>A0AAJ0LZ67_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_539018</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718859.1">
        <property type="nucleotide sequence ID" value="XM_062869714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZ67"/>
    <dbReference type="GeneID" id="87888543"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF236">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G12060)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="13"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3303079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="424" mass="47950" checksum="131D7B1A3CBD3A79" modified="2024-07-24" version="1">MADFPRLPPSGIKVIIVGAGFAGLTAAIECDRKGHSVTLFDRAPELQPLGDIISFGQNSSRIFDKWPGVREAINPLVHKSEVFHFHDWRGRFVTTQSFVDEHRTWGPRVNGHRGEIHQAVLRHAKERGIDIRLGHHIVRYFEDDACAGVETDKGERFTADLVLAAEGVRSPGRKLVLGFEDKPQPSGYAVFRTWFPSDELLKNEKTRHLVANGDSHNGWIGEDVHFLAAAIKDGKEMSWVCTHKDTGSIEESWQFPGKIEDVLRVVDGWDPVVRELVKLTPPDRLFDYKLVFRDPLPTFISPKARTALIGDAAHPFLPTSIQGASQAMEDGVVLAACLHKAGKGKVQEALKVWERIRYERVHKIQRTGVTTREQWHKADWEAIWKDPESLHLKREAWILDFDAEADAYASYDSVREQLENGRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZA2</accession>
    <name>A0AAJ0LZA2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoenolpyruvate carboxykinase (ATP)</fullName>
            <ecNumber evidence="3">4.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0T15DRAFT_401624</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>oxaloacetate + ATP = phosphoenolpyruvate + ADP + CO2</text>
            <dbReference type="Rhea" id="RHEA:18617"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.49" evidence="3"/>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719007.1">
        <property type="nucleotide sequence ID" value="XM_062865121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZA2"/>
    <dbReference type="GeneID" id="87883950"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004612">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00484">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.8.10:FF:000001">
        <property type="entry name" value="Phosphoenolpyruvate carboxykinase (ATP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.449.10:FF:000002">
        <property type="entry name" value="Phosphoenolpyruvate carboxykinase [ATP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.449.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.8.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00453">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001272">
        <property type="entry name" value="PEP_carboxykinase_ATP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013035">
        <property type="entry name" value="PEP_carboxykinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008210">
        <property type="entry name" value="PEP_carboxykinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015994">
        <property type="entry name" value="PEPCK_ATP_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00224">
        <property type="entry name" value="pckA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006820">
        <property type="entry name" value="PRK09344.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006821">
        <property type="entry name" value="PRK09344.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30031:SF0">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE (ATP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30031">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01293">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006294">
        <property type="entry name" value="PEP_crbxkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68923">
        <property type="entry name" value="PEP carboxykinase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53795">
        <property type="entry name" value="PEP carboxykinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00532">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3303227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="595" mass="65765" checksum="775FE95CE5C0A217" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M071</accession>
    <name>A0AAJ0M071_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_231426</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719924.1">
        <property type="nucleotide sequence ID" value="XM_062862948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M071"/>
    <dbReference type="GeneID" id="87881777"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF66">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3304144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="305" mass="31961" checksum="D4067A57E73672AE" modified="2024-07-24" version="1">MSDSAQRRVQAIGDQLAGETSIPPIFKVAPSGPRVAGKVVIITGTNSILGIGRASAHQFAEHGAKAVYICDYDDTNLEAHKREINALFPQVDVHTRQFDAADEKAVKEVIDDAMKRYGRLDVFFANAGTIGPHALFTEIDADDFMETMRVNSLGVFLAAKHAAPAMQVTSATKPTPSGSIIATASVAGLRSNAGSTPYSASKAAVVSMAQTVAFQLAGTGVRINALCPGLIETGMTAPVFEMARARGTQGRIGQLNPLKRAGHADEIARVALFLGSDESSYVNGQAWAVDGGLSAGHPYVPGRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M099</accession>
    <name>A0AAJ0M099_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Terpene synthase</fullName>
            <ecNumber evidence="4">4.2.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_557606</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the terpene synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.-" evidence="4"/>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719923.1">
        <property type="nucleotide sequence ID" value="XM_062870450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M099"/>
    <dbReference type="GeneID" id="87889279"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010333">
        <property type="term" value="F:terpene synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034686">
        <property type="entry name" value="Terpene_cyclase-like_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201:SF4">
        <property type="entry name" value="BETA-PINACENE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201">
        <property type="entry name" value="TERPENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19086">
        <property type="entry name" value="Terpene_syn_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3304143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="348" mass="38213" checksum="5A551FC400D427EF" modified="2024-07-24" version="1">MPSTTLHAESAHPLKDIVPPTVLSQATIHPNAEEIDREVVTYLVDTWEWPSEKHKQGFISWKLSEVVLFMFPTGETNRVKLATELLLLGFLMDDWFDHHPLAENSLVVSRLQSLLSSSSSSSPPSPLSNSISPLTLTTTIDRMHASLFARILAVPTPRDSSSRRVLEAYMAMLACHCEASRGTGAASAALGDYLAFRETDVGMPICAELLYWTEPDLDAALGGAAERAMLRPLDRVANYHVSILNDVFSFEREWKAAQALEDGAVLVNGVAVLAKEANLSVHAARQLCLGLVRAWEVEFLSMAEGLLGSYGLGGQQGEARSLMDRAIKGIERRMTGAEAFSWRTSRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M0C6</accession>
    <name>A0AAJ0M0C6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_536124</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720102.1">
        <property type="nucleotide sequence ID" value="XM_062869536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M0C6"/>
    <dbReference type="GeneID" id="87888365"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051229">
        <property type="entry name" value="ALYREF_mRNA_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025715">
        <property type="entry name" value="FoP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965">
        <property type="entry name" value="RNA AND EXPORT FACTOR BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965:SF35">
        <property type="entry name" value="RNA ANNEALING PROTEIN YRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13865">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01218">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="70"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="161"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="192"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3304322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="250" mass="25979" checksum="218128E3BE6ACEF2" modified="2024-07-24" version="1">MSAKLDQSLDEILSSQRRNQNGRRRSTRRAAGANRPAPAAPAGGIKKSSKGARNTAKPTPAKGAGLTGESKIMVSNLPKDVSEAQIKDYFQQSVGQVKKVELSYGPGGVSRGIAHVTFHHADGASKAFSTLNGLLIDNKPVKVEVVVASADLIPQPKPLSQRIVQPKAQPKSAAAVKQNGGGTKGGAASSRGGKKTGRRGRSNRPVKKTAEELDSEMMDYFESGNPENNVNGAAAAAAAGGDATMEDDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="6">Small ribosomal subunit protein mS33</fullName>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
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    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
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            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00035132"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="104" mass="12025" checksum="D07F4414FD75C478" modified="2024-07-24" version="1">MSVPRARLLDLMRARCELFATTFNPDGIRTGNKILRQRLKGPALASYYPLKLTTFRDFQNEFKPLELEVENEEELDRLEHIAALKARGKGAPKKKRTKVVNKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M0G2</accession>
    <name>A0AAJ0M0G2_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">B0T15DRAFT_512580</name>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
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                <person name="Kuo A."/>
                <person name="Mondo S."/>
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                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
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                <person name="Ament-Velasquez S.L."/>
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                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062867996.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87886825"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
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        <property type="entry name" value="ATHOOK"/>
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        <property type="entry name" value="AT_hook"/>
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    <proteinExistence type="predicted"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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    <feature type="region of interest" description="Disordered" evidence="1">
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        <location>
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        </location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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    </feature>
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        </location>
    </feature>
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    <feature type="compositionally biased region" description="Pro residues" evidence="1">
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    </feature>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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    </feature>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1477"/>
            <end position="1488"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3304427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1578" mass="170977" checksum="7B63BD39CBD2A991" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M0I4</accession>
    <name>A0AAJ0M0I4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AEX-3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_243664</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
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        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
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                <person name="Martin F."/>
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                <person name="Ament-Velasquez S.L."/>
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                <person name="Grigoriev I.V."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
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        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
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                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
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                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
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        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
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                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
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                <person name="Natvig D."/>
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                <person name="Ament-Velasquez S.L."/>
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                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
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    <name>A0AAJ0M0L4_9PEZI</name>
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    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
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                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720375.1">
        <property type="nucleotide sequence ID" value="XM_062869589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M0L4"/>
    <dbReference type="GeneID" id="87888418"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000149">
        <property type="entry name" value="Alpha-1,6-mannosyltransferase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008630">
        <property type="entry name" value="Glyco_trans_34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306:SF10">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05637">
        <property type="entry name" value="Glyco_transf_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3304595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="315" mass="35865" checksum="8FBDD3BFF12A288D" modified="2024-07-24" version="1">MHFALPPRKTSHPPPYVPRSTRLPGLRKTRLKLIALAGLAFLALVYLITRPSSGGHAARAQRAPRGNPPVVLVTVLDHSKYTKAYLDAVKENRRQYAEKHGYQTLIAQVGDYDLKGAPFSWTAVPAVRHALSKYPDCHYVWYLDANSFIMNPKLKVEEHIMQSSRLDELMKKDFPVVPPDSIIKTFSHLKGQDVDFVVTQDKEGLSPGSLIVRNGDWAKFFLETWFDPLYRSYNFQKAEKHALEHIVQWHPTILARMAIVDQRLMNAYNKGAKEALYQNGDLAVRFPDCETSGGKACETETESFVQAWRRLFEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M0X8</accession>
    <name>A0AAJ0M0X8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0T15DRAFT_437691</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720716.1">
        <property type="nucleotide sequence ID" value="XM_062865854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M0X8"/>
    <dbReference type="GeneID" id="87884683"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF13">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="108"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="493"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="532"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="565"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3304936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="612" mass="70014" checksum="CE85C9205E6326CF" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M115</accession>
    <name>A0AAJ0M115_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_531151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3305041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="472" mass="53946" checksum="08929DD8D3AC79E9" modified="2024-07-24" version="1">MEHINFDWLDGDSALNYATPEFLTTDSPGIGPAAERASPVAEQAEQQNGERPLPLLRLSGWESNKQYDKNSPECIHYDFRWKVSQRENIRARHVCSDTDPDLVLAPSDFWRVNFKTRLETLLKDKDKFPGDAYTCEETIIDISIERSRQRGLKKRFNNMEIDWKVVDGHLEGLSALFSKRRKITFSIEFIYKEVASDPTIAKGKKKKQSATEAQKLQRAAEAGLWARVYERHRCRGKHCKQGPHCWPDERGNHHRLLPRHLEDLVRHIKGNMKEGEKEEDVDVNIEIPPRILKDVLDNNRKRKPEDSIGCRNCKTHVSAHSGHHDAAGASLEDVTDVDGNRKDKLEEYCNWTLQQVKSDRWREALQAANQFALDQFLELNSILQHPTLAANLMIKGGVKPGIALQFVSNIKKFQLLRVCWENMPSSSATELRNLDSGGTLRRPAPTPVSRPSIAARLINKDKLVGLVLRYPM</sequence>
</entry>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721455.1">
        <property type="nucleotide sequence ID" value="XM_062862621.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87881450"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
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        <location>
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            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="1339"/>
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        </location>
    </feature>
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        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="485"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1367"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1386"/>
            <end position="1396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3305675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1396" mass="156997" checksum="9B8C5D5807FDB2F6" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M247</accession>
    <name>A0AAJ0M247_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
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        <lineage>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3306138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721918.1">
        <property type="nucleotide sequence ID" value="XM_062867953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M247"/>
    <dbReference type="GeneID" id="87886782"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3306138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="117" mass="13413" checksum="9827A1A11432956C" modified="2024-07-24" version="1">MSSSETTPDRTPQPRTIIPDINVPDPTADEIDLAGQSWVMATVIEDDDLMFGGKPLCDWYEEDRRALSSCIDEEQTRGRPRERAHIESHHHDKAHHHHQVKHERKVNERAASCPARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M2E5</accession>
    <name>A0AAJ0M2E5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rad60/SUMO-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_144150</name>
    </gene>
    <organism evidence="3 4">
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722325.1">
        <property type="nucleotide sequence ID" value="XM_062861916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M2E5"/>
    <dbReference type="GeneID" id="87880745"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022617">
        <property type="entry name" value="Rad60/SUMO-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11976">
        <property type="entry name" value="Rad60-SLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad60/SUMO-like" evidence="2">
        <location>
            <begin position="377"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3306545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="455" mass="50650" checksum="E50DAE6736AE983B" modified="2024-07-24" version="1">MADLDEPPKKRALPFKRTVARKQQSSAEPEKAEDENDLDLFRHSKEVFPEILREAQEEDERQHDRKRRKTSEDTPRTNRKHSSGSSDDLSYGNKRSISVDGSDDDLIMDIKGKGKEISRARTVSVPRKTVSRKATPRTPGPNGNITGTCGSNQPDGSPAFPVTIPDDNDDDDVIPLGSLNRQYAQDDDGSSVVLVDNSNDPEAGEVQQTVEQDEFSEWVAKARELQARQSHDAIVKVFLESRVPGADKPMLVKRRLNQTCQLILDVWVATATREGIEIPDDLASSLFLAWKGNKIYGHSTLSSLGVEVDERGNLKHSQGDGYSRGGIQLEIWSEQGYAEYLKHRGKERAVLGADDGDLSGSEGEEEPLPPPPKKKGIKIVLKAKEHEPLKLSTRDETTVEMLIEAFRAQRNVGPEWDVAIHFDGERLVEDALVMDIDVDPDDVNQLEVHIKKAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M303</accession>
    <name>A0AAJ0M303_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">OPT oligopeptide transporter protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_165674</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722907.1">
        <property type="nucleotide sequence ID" value="XM_062862159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M303"/>
    <dbReference type="GeneID" id="87880988"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="471"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="498"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="580"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="648"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="701"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="733"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3307127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="785" mass="86755" checksum="F6DCB07B126DC61A" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M312</accession>
    <name>A0AAJ0M312_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutathione-s-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_553608</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722937.1">
        <property type="nucleotide sequence ID" value="XM_062870326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M312"/>
    <dbReference type="GeneID" id="87889155"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03048">
        <property type="entry name" value="GST_N_Ure2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF3">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR URE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="8"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="95"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3307157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="222" mass="25363" checksum="3BB2A13896325B6A" modified="2024-07-24" version="1">MGSIVHLKPLKLYSHKRGPNPWKVAVILEELAIPYFSEYVEFEDTKVEPYILLNPNGKLPVLEDPNQEIVLFESGAIIEYLVDQYDVDGKLTPESPQEKWLARSWLHLQMSAQGPACGYKIWLNRTYAPDALVAANEFFTKEIQRVVGVLDGQLQRRKDPFLLGPKMSYADLAFVPHYLMLSLFVPGYDPAVEYPHFAAWLERMKEQSSVKKIVAAKEALLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M337</accession>
    <name>A0AAJ0M337_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Signal recognition particle subunit SRP68</fullName>
            <shortName evidence="10">SRP68</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0T15DRAFT_432085</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the SRP68 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722744.1">
        <property type="nucleotide sequence ID" value="XM_062865748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M337"/>
    <dbReference type="GeneID" id="87884577"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15481">
        <property type="entry name" value="SRP68-RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.40">
        <property type="entry name" value="Signal recognition particle, SRP68 subunit, RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026258">
        <property type="entry name" value="SRP68"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034652">
        <property type="entry name" value="SRP68-RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038253">
        <property type="entry name" value="SRP68_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 68 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860:SF0">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16969">
        <property type="entry name" value="SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038995">
        <property type="entry name" value="SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0733">Signal recognition particle</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="595"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3306964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="617" mass="67468" checksum="EDD1D745519C7740" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M3H2</accession>
    <name>A0AAJ0M3H2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrophobic surface binding protein A-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_433445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723476.1">
        <property type="nucleotide sequence ID" value="XM_062865774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M3H2"/>
    <dbReference type="GeneID" id="87884603"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021054">
        <property type="entry name" value="Cell_wall_mannoprotein_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38123">
        <property type="entry name" value="CELL WALL SERINE-THREONINE-RICH GALACTOMANNOPROTEIN MP1 (AFU_ORTHOLOGUE AFUA_4G03240)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38123:SF6">
        <property type="entry name" value="CELL WALL SERINE-THREONINE-RICH GALACTOMANNOPROTEIN MP1 (AFU_ORTHOLOGUE AFUA_4G03240)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12296">
        <property type="entry name" value="HsbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042559693" evidence="2">
        <location>
            <begin position="19"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3307696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="262" mass="26297" checksum="732E23ADDCCB1B35" modified="2024-07-24" version="1">MHLVRFVLQATLAYGAVAFPSTSERRDLGTIQSAIGTVQSALEKLNTAVNGLTADPQTAAPILTASQNAQAALQKATQDISGSDELGLISALRLQQMANGLTSAVQTAMDSLVAKKPVLDQLGVTSVAVMSLQTQQSASAAFGDALVSKVPAIGRGLARQSINQVNEILDKGIQDLQRAGAGAEGGASTATSAITTSSASATTVVGSTTAATSVAPSFVSAPINENGSETETETETATATSTVDAPEEGVSSLPPAASGLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M3L5</accession>
    <name>A0AAJ0M3L5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_522474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3307757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723537.1">
        <property type="nucleotide sequence ID" value="XM_062868634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M3L5"/>
    <dbReference type="GeneID" id="87887463"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3307757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="101" mass="11047" checksum="43B515993D9690EE" modified="2024-07-24" version="1">MVIYLWRALAGILSKAIAMAASSTVYRFCSSLVPRVIANLVTVSLVLLKRLVTITMPMALLAILVAFSRSALIIGYRRGAQGAIVYFWIVSIRSVFIPSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M3P9</accession>
    <name>A0AAJ0M3P9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,4 glucan phosphorylase</fullName>
            <ecNumber evidence="10">2.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_183931</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="10"/>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723389.1">
        <property type="nucleotide sequence ID" value="XM_062862352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M3P9"/>
    <dbReference type="GeneID" id="87881181"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04300">
        <property type="entry name" value="GT35_Glycogen_Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000002">
        <property type="entry name" value="Alpha-1,4 glucan phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000003">
        <property type="entry name" value="Alpha-1,4 glucan phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011833">
        <property type="entry name" value="Glycg_phsphrylas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035090">
        <property type="entry name" value="Pyridoxal_P_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02093">
        <property type="entry name" value="P_ylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468:SF3">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE, LIVER FORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000460">
        <property type="entry name" value="Pprylas_GlgP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00102">
        <property type="entry name" value="PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="8 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000460-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3307609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="893" mass="101214" checksum="58CEEE3822CD9F30" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M4E1</accession>
    <name>A0AAJ0M4E1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_107608</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724199.1">
        <property type="nucleotide sequence ID" value="XM_062861445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M4E1"/>
    <dbReference type="GeneID" id="87880274"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3430.10:FF:000003">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029:SF10">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="389"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="9">
        <location>
            <begin position="37"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3308419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="478" mass="50666" checksum="44BA9CA36291694F" modified="2024-07-24" version="1">MSAGPLTEYGGVTGVADDGGNSLTDDLNVYYSSGDFAWIMTSAALVLLMVPGVGFFYSGLARRKSALALIWLSLISIAVVGFQWFFWGYSLTFSHTGSAYIGDLSNFGLMKVLGQPSVGSTKVPDLLFCLYQGMFAAITPALAIGAAADRGRMLPCVVFIFVWATIVYDPIAYWTWNANGWSFKMGGLDFAGGTPVHISSGAAALAYSLMLGKRTGYTKLNGLPHRPHNVTHVVLGTVFLWVGWFGFNGGSALAANMRAVMACIVTHISACVGGFTWCLLDYRLEKKWSTVGFCSGAIAGLVAITPGSGYVPPWSAVVFGVVGGIVCNLATKLKFVLGIDDALDIFAEHAVGGIAGNILTAFFAADYIAHLDGFSEIPGGWVNHNYVQLGYQIADSVAGFSYSFVLTCVILFIMNLIPGLSLRVPAAEEEMGLDDGELGEFAYDYVEITRHVDGDLTGMSGTPAHSIKGGNIPAGKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M4I6</accession>
    <name>A0AAJ0M4I6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">INO80 chromatin remodeling complex Ies1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_411500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724528.1">
        <property type="nucleotide sequence ID" value="XM_062865395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M4I6"/>
    <dbReference type="GeneID" id="87884224"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038014">
        <property type="entry name" value="Ies1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37287">
        <property type="entry name" value="INO EIGHTY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37287:SF1">
        <property type="entry name" value="INO EIGHTY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="567"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="599"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="623"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="661"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="681"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3308748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="715" mass="79789" checksum="5A9E37A714E3C24A" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M4R1</accession>
    <name>A0AAJ0M4R1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_525945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3309017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724797.1">
        <property type="nucleotide sequence ID" value="XM_062868879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M4R1"/>
    <dbReference type="GeneID" id="87887708"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3309017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="181" mass="19731" checksum="58A2DFF96BE48F30" modified="2024-07-24" version="1">MELITPLSVPFFFPTLCHCGNHCPLTAVGLPYTIKRTLVSVRRQPRDYCPLLNANPFVVSQNIGPAQGGPLILPLVLNSPQPAETPVITNDRRSVALAQQENRINLGSFTRFKACCLWHFFSPYLSIARRGFGQVTTKRHAGMPGRSILSGSAETIGAKVWSGTIPSAIHFHGRPGPSSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M4X6</accession>
    <name>A0AAJ0M4X6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_509390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724769.1">
        <property type="nucleotide sequence ID" value="XM_062867780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M4X6"/>
    <dbReference type="GeneID" id="87886609"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057203">
        <property type="entry name" value="DUF7881"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25324">
        <property type="entry name" value="DUF7881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7881" evidence="2">
        <location>
            <begin position="8"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="HNH nuclease" evidence="1">
        <location>
            <begin position="134"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3308989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="207" mass="23175" checksum="B6597A609220E8D2" modified="2024-07-24" version="1">MSGRRALGRNVFIWHLNGDNEDRIPLGGLVLTAGVTNTGFRQMLDILLITSGDCVVQNEHGDETLRDDQPLLPGDYTVSADSVEVTKVNNEVVYTRSHSIATGTRVESFKEEVQARDAYERQWDDNNYGRWITIDPPQGVGKINSVQNGIILRADLHILFDCFAFSINPDDFPPGSDIMGEIMAGPKAAERMEFELFDRLAHHMEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M565</accession>
    <name>A0AAJ0M565_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_4203</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725263.1">
        <property type="nucleotide sequence ID" value="XM_062865538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M565"/>
    <dbReference type="GeneID" id="87884367"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658:SF8">
        <property type="entry name" value="17-BETA-HYDROXYSTEROID DEHYDROGENASE 14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="3">
        <location>
            <begin position="6"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3309483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="262" mass="27453" checksum="0115167668674AC5" modified="2024-07-24" version="1">MKISGRTFVISGGASGLGRACVRDICADGGNAVILDMNEDLGNSLAAELGPSAKFFVCDVSDTESIASAVKSTVSWVKETGKPLGGIIPAAGVGHPGLILDKQLRPVSLESVDFVLSINLRGTLDLVRQLLPHLAATTPQGPDNERGVVVMVASAAAFEGQMGQVAYAASKGAVAAMTLPMARDLSRFGIRVVTIAPSMFESNMTAALSDKVREGLQKAMEFPRRAGQPEEFASLVRQAIENVMLNGTVIRLDGATRMPSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M573</accession>
    <name>A0AAJ0M573_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycoside hydrolase family 76 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_389760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309513.1"/>
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        <location>
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        <source>
            <dbReference type="EMBL" id="KAK3309513.1"/>
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            <dbReference type="Proteomes" id="UP001273166"/>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062867567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M5J9"/>
    <dbReference type="GeneID" id="87886396"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3309617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="152" mass="17430" checksum="5AE2B640A6B1BD39" modified="2024-07-24" version="1">MRSSREYFVAQGLRRVTHTYYYFKDMKELDGLARKPTASMSCVTFWLDERQADQHYVTTMDPSDLTFIMSAVNDTANITAVVVTTITITTTPYRVHDALAASTRIVEAGKYRTYKVAVKYDSEGQVKESRCMRARVVPRSMKEMVNNFSGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M5L4</accession>
    <name>A0AAJ0M5L4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_488375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725442.1">
        <property type="nucleotide sequence ID" value="XM_062866506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M5L4"/>
    <dbReference type="GeneID" id="87885335"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="909"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="942"/>
            <end position="991"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3309662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="998" mass="111914" checksum="EF1E1DA0165495C7" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M5Z0</accession>
    <name>A0AAJ0M5Z0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoinositide 5-phosphatase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_24985</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptojanin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.36" evidence="4"/>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725895.1">
        <property type="nucleotide sequence ID" value="XM_062863158.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87881987"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043813">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09090">
        <property type="entry name" value="INPP5c_ScInp51p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000029">
        <property type="entry name" value="Inositol polyphosphate 5-phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF257">
        <property type="entry name" value="PHOSPHOINOSITIDE 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SAC" evidence="10">
        <location>
            <begin position="191"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="972"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1076"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1213"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1242"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1076"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1134"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1223"/>
            <end position="1232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3310115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1336" mass="146855" checksum="088D07A9D20A529C" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M678</accession>
    <name>A0AAJ0M678_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Signal peptide-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_37111</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726194.1">
        <property type="nucleotide sequence ID" value="XM_062864200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M678"/>
    <dbReference type="GeneID" id="87883029"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042526025" description="Signal peptide-containing protein" evidence="2">
        <location>
            <begin position="26"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3310414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="458" mass="51024" checksum="050D47B5FDB3DA11" modified="2024-07-24" version="1">MSYLVAAQSALFYFLACTPCNQLQAQRKTRQQAKKDRVIKERIVMEQPHLYRHPDPFHTNPYWGEEIRMGPSLPKKRKGSDGISKSLSQRRLTVASRDGRPSIGTGSSVVVSMSDMASISSPRPSTNPIDIHLGSAPTVVPEEEAMSPTLSKTASISTSADWNVKRYQREDEELWGHESTWSGHKLMDAIKHAGTTAGRYMESKLGLEKQVTDEDRYNFYFTPRNPPVNEYHPPVVSSKPAHKDALRWMLQPPPPAKVMEGKVPVTRSTSTMSAASRRTVSTRDGGSLGRLVGERAVEARIRRGETPFEDEWRPTSPLRKSLSRVSSATRMRSRRTARTNYSSTDSDEEPDAASNRRRRRSHRPPEVESEDDEDDEGSYASRGAETLSNTSLSTHAAQKPRLPTNPSSGYDGRGASKVEHIESAHPSRETISPTPRTEFSKPETQSAMSINTDVAVHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M715</accession>
    <name>A0AAJ0M715_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Translation initiation factor SUI1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_521461</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Additional factor that functions in concert with eIF-2 and the initiator tRNA in directing the ribosome to the proper start site of translation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SUI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727211.1">
        <property type="nucleotide sequence ID" value="XM_062868561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M715"/>
    <dbReference type="GeneID" id="87887390"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11566">
        <property type="entry name" value="eIF1_SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.780.10:FF:000005">
        <property type="entry name" value="Sui1 translation initiation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005874">
        <property type="entry name" value="SUI1_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01160">
        <property type="entry name" value="SUI1_MOF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10388">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004499">
        <property type="entry name" value="SUI1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="SUI1" evidence="6">
        <location>
            <begin position="33"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00060093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3311431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="121" mass="13691" checksum="254E72C48B241778" modified="2024-07-24" version="1">MSGEIEIQNLKSRDPFADADEDSGQTTQTQEYIHIRIQQRNGRKTLTTVQGIPAKFDHKKILKVIKKEFACNGTIISDTESKGLGEVIQLQGDHRLKIKEFLVDKEEGLGLDEKNIKIHGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GKF7</accession>
    <name>A0AAJ0GKF7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_316822</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717366.1">
        <property type="nucleotide sequence ID" value="XM_062864002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GKF7"/>
    <dbReference type="GeneID" id="87882831"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF46">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="332"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="448"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="62"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3301586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="505" mass="56556" checksum="F8039B5641214031" modified="2024-07-24" version="1">MSELKHPSDEEDAKRHGGIDNPNPTHHAFSPPYDSVSLTSGEVVCPAHTTERKITTKIDMHLIPFVSILYLMAFLDRVNIGNARAFGLEADLGLGGVEYNTALTIFFVPYIIFEIPSNILLKHFSPRVWLSICCIGFGFVTAMQGLVQNYSGLLATRFFLGLFEAAMFPGCFYLLSTWYRRHEAQKRFSFFFSSTSLAGAFGGLLASGIGKMDHVRGYRGWRWIFILEGCFTLVVGVIFLFTFPTFPEQTTWLREDEREFVKARLKASQGHSGAERKITARDVLTVMSDYKIWLGGFMYFGLIVPAYSYAYFSPTIIQSYKYDAITTQLRSVPPWAVAFGFAMVVAVASDWLKHRFLFVMGAICIAIAGFAVLLNVHDNLPVQYAALFLVCMGTYSAMPVIVCWFNMNLGGHTRRAIGSAWQIGFGNIGGIIATYSFVQSDAPFYRKGYAICVSFICLSAVSSIAYALSVVWENGKRSKQPHNLNLTESEKIELGDLNPEFRYML</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GKH3</accession>
    <name>A0AAJ0GKH3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_405114</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SWD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717380.1">
        <property type="nucleotide sequence ID" value="XM_062865283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GKH3"/>
    <dbReference type="GeneID" id="87884112"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016070">
        <property type="term" value="P:RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037867">
        <property type="entry name" value="Swd2/WDR82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861">
        <property type="entry name" value="WD40 REPEAT PROTEIN SWD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="142"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3301600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="378" mass="41205" checksum="3722DFFE7C28E7FB" modified="2024-07-24" version="1">MASTPMDIDDLPPATAPSLNITRTLGASNVPSTTAVSDVISAFRPTKLFQRDDIKEGKPQPYILSIDFDDPGELCMTSESDETIQIYNVKDGRHDKSLLSKKYGVKLAKFTHTSSSIIYASTKQNDAIRYLATHDNSFIRYFEGHEGAVTDLALHPGADNFISCSVDNTALIWNIGTKQWTGKLFLNTPYLSAWDPSGNAFAIASPSSGSVLLYDYRNYEKGPFSVFDVLKARGPADPEGAFRGWTKLEFSNDGKHLLLGSRGDGHFLLDSFDGSLKAYLKKPGASTRRLAAGEADGGNVEGSGECCFAPDGRYVLSGAKSDLLVWDTLATPGTDKVLEPAHVLEEKREAAVVAYNPRYNMIATGDQELVFWLPDPNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GKK2</accession>
    <name>A0AAJ0GKK2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytoplasmic tRNA 2-thiolation protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">NCS2</name>
        <name evidence="3" type="synonym">CTU2</name>
        <name evidence="4" type="ORF">B0T15DRAFT_317198</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CTU2/NCS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GKK2"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03054">
        <property type="entry name" value="CTU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019407">
        <property type="entry name" value="CTU2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882:SF14">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10288">
        <property type="entry name" value="CTU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3301602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="411" mass="44674" checksum="FE951C26BA9D6D2C" modified="2024-07-24" version="1">MEEEKPTEGPLTKPCVKCRAQEATLESRTHAVCRNCFTKFIAGKCIKQIGLLGKETRHPQSTAGGPPNTTRRYLLGLSLGVSSTVLLHLLNENIEFQLAKGRNAPFELRVVHIDNAILHKPQTIFSPTQQALSRLVRRYPRFQFQCIPLSSVLTDLDLTSLPLPPGTSQSIRTLLTTLPTAASREDILRLLTRQALISLARTQHCQALLLGHSTTALAELTLAETAKGRGYALPWLINDGPAPSHPDDEEEEEEVVVVTNGAGNDKPSLLIYHPLRDALRKELVTYARLIDPPLTELAVTGADGHQNGAPAVVSHRDLTIEEVMDRYFAEVEENYPSVVANVARTTGKLVRAGEEARGGGEGGGERCGLCGMPLDEIGDERWRGELGLGTGIKTADGQGRLCYGCERSTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GKK5</accession>
    <name>A0AAJ0GKK5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">MYB DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_487873</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717425.1">
        <property type="nucleotide sequence ID" value="XM_062866465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GKK5"/>
    <dbReference type="GeneID" id="87885294"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019185">
        <property type="term" value="C:snRNA-activating protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042795">
        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042796">
        <property type="term" value="P:snRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051575">
        <property type="entry name" value="Myb-like_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46621">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46621:SF1">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="217"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="7">
        <location>
            <begin position="221"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="110"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3301645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="274" mass="29529" checksum="64745B74428132A7" modified="2024-07-24" version="1">MHSARRRAPSTPERSPPAHYTAAHHPHPILTDPAHLSGHPSARHMGHPGPPHFGAGPSPHAVVAPLYPSLTPTHGHAAGLKRPRPDELDLSVSGMPGLQHGGLESMQQTPMGAAYPQAAAAPPTHHHHRLPDTGPPSKLLRRDEEGSSGGGGAPSMVGQAGMPPPAPRPRGPKLKFTPEDDQLLVDLKENKNLTWKQIADFFPGRSSGTLQVRYCTKLKAKTTQWTDETDQKLKTALQDYENEKWRIIANKVGTGFTPAACRERAAQLLGEESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GLQ0</accession>
    <name>A0AAJ0GLQ0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_403104</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717997.1">
        <property type="nucleotide sequence ID" value="XM_062865190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GLQ0"/>
    <dbReference type="GeneID" id="87884019"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF77">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="478"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3302217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="512" mass="57116" checksum="22259CDC62140198" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GNU9</accession>
    <name>A0AAJ0GNU9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">3-methyl-2-oxobutanoate hydroxymethyltransferase</fullName>
            <ecNumber evidence="3 6">2.1.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_401254</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = 2-dehydropantoate + (6S)-5,6,7,8-tetrahydrofolate</text>
            <dbReference type="Rhea" id="RHEA:11824"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the PanB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.11" evidence="3 6"/>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719182.1">
        <property type="nucleotide sequence ID" value="XM_062865098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GNU9"/>
    <dbReference type="GeneID" id="87883927"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003864">
        <property type="term" value="F:3-methyl-2-oxobutanoate hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06557">
        <property type="entry name" value="KPHMT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000003">
        <property type="entry name" value="3-methyl-2-oxobutanoate hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00156">
        <property type="entry name" value="PanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003700">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00222">
        <property type="entry name" value="panB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001452">
        <property type="entry name" value="PRK00311.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881">
        <property type="entry name" value="3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881:SF0">
        <property type="entry name" value="3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02548">
        <property type="entry name" value="Pantoate_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3303402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="340" mass="36387" checksum="B96C32AC246C2280" modified="2024-07-24" version="1">MYLSSLGRSCVSSLTRSARPSHLFLQGLRVPAVLQQSQTQARWSSHSPMGSPPTEPRKKVTIGKLRAMHRKGEPITMITAHDFPSAHVADAADIDVILVGDSLAMVALGMEDTSEIVVEEMLLHCRSVARATKSAFVVGDLPMGSYEAGPTQALQTAIRFVKEGRMQGVKLEGGKEMVPAIQKITTAGIPVLGHVGLTPQRQNMLGGFRVQGKTAASAMEVLDDALAVQKAGCFAVVLEAVPAEVAAIVTQKLSIPTIGIGAGNGCSGQVLVQIDMTGNSPPGRHLPKFVKKYGDVWSESLRAIKTYREEVKTRQYPAPEHTYPIAKEELEGFAEAVKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GPD8</accession>
    <name>A0AAJ0GPD8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_281127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719416.1">
        <property type="nucleotide sequence ID" value="XM_062863575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GPD8"/>
    <dbReference type="GeneID" id="87882404"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042467669" evidence="1">
        <location>
            <begin position="22"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3303636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="94" mass="9889" checksum="B8FE0CC8B7D86CA2" modified="2024-07-24" version="1">MVLLTLKLLLAAIFAAGVAVAQNCEVRYKPEGPRRVDGCTNISRMIVAGRLANSSLIRVSDTCSSTACKLSPSSVGHAVPVRAKRTTTRTMSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GPE8</accession>
    <name>A0AAJ0GPE8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_282427</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Luc7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719482.1">
        <property type="nucleotide sequence ID" value="XM_062863600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GPE8"/>
    <dbReference type="GeneID" id="87882429"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004882">
        <property type="entry name" value="Luc7-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12375">
        <property type="entry name" value="RNA-BINDING PROTEIN LUC7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03194">
        <property type="entry name" value="LUC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="232"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="251"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3303702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="287" mass="31666" checksum="C72EF82D846AD100" modified="2024-07-24" version="1">MAAEQRKLLEQLMGGGMASRTAQLPLTDPKVCRSYLVGTCPHDLFTNTKADLGACPRVHSEALKAEYEALPEAEKKKYGFEYDYMRDLQNRIDACNRNIDTLQRRLEKTPDEVRQTNALLKTISDLGSTIANGLLEVEILAEMGEVSRAYDEYYKVRHAQAAKAEREKELKALSETSGPSGHQKLQVCDVCGAYLSRLDNDRRLADHFFGKMHLGFAQMRKAYDAFPKEMRGRQRAPMPMGGGGDEDMGGVPTGPGGGYNDGGWGKGPRGPRSGGGYRGSRGGRRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GPQ3</accession>
    <name>A0AAJ0GPQ3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PUA-like domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_286231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719642.1">
        <property type="nucleotide sequence ID" value="XM_062863640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GPQ3"/>
    <dbReference type="GeneID" id="87882469"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3303862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="22902" checksum="24DB03A935A3DF29" modified="2024-07-24" version="1">MAPSRPELRQATLDSHFRQSTNRISKKPRPPQAESEKSRSVARPAANAKRLGGDRVLTDVLLAIKPVHLANIASQQKNHEYRKYRLHDGVTRLWFYETGDEGGRSAITHIAVIPSSVRRTPGTVPTEPFGIGNDDFNAGRKESKYGYPILELYELTKPVGLAEMKSRWGFGAPMGWRYVGADLWEDRWGDDGDNRDAKVRKVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GPX9</accession>
    <name>A0AAJ0GPX9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">chitinase</fullName>
            <ecNumber evidence="4">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B0T15DRAFT_541155</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="4"/>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719540.1">
        <property type="nucleotide sequence ID" value="XM_062869838.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87888667"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00035">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02878">
        <property type="entry name" value="GH18_zymocin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053214">
        <property type="entry name" value="LysM12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47700:SF2">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47700">
        <property type="entry name" value="V CHITINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13720)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="6" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="11 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 13 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042593050" description="chitinase" evidence="15">
        <location>
            <begin position="19"/>
            <end position="1559"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="16">
        <location>
            <begin position="354"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="17">
        <location>
            <begin position="567"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1229"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="1254"/>
            <end position="1263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK3303760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1559" mass="169406" checksum="3863BBD1A1E47461" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQK2</accession>
    <name>A0AAJ0GQK2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Class I glutamine amidotransferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_235547</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
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                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <location>
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            <end position="22"/>
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            <end position="265"/>
        </location>
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        <location>
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            <end position="224"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GR45</accession>
    <name>A0AAJ0GR45_9PEZI</name>
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        <recommendedName>
            <fullName evidence="5">GRIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="6" type="ORF">B0T15DRAFT_558388</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
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            <taxon>Sordariomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
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                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
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                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
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                <person name="Steindorff A."/>
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                <person name="Martin F."/>
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                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
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        <subcellularLocation>
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    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="GRAB"/>
    </dbReference>
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        <property type="entry name" value="GRIP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18921">
        <property type="entry name" value="MYOSIN HEAVY CHAIN - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18921:SF2">
        <property type="entry name" value="THYROID RECEPTOR-INTERACTING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10375">
        <property type="entry name" value="GRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50913">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GRIP" evidence="5">
        <location>
            <begin position="467"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="580"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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    </feature>
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        <location>
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        </location>
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    </feature>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3304571.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
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                <person name="Lalanne C."/>
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                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
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                <person name="Ng V."/>
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                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
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                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720487.1">
        <property type="nucleotide sequence ID" value="XM_062863180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GRF7"/>
    <dbReference type="GeneID" id="87882009"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="429"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="61"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="343"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="354"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="435"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="446"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3304707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="494" mass="53825" checksum="FB8EB8AD7ED56E57" modified="2024-07-24" version="1">MSSKDINTHAATVEALLRNLSANPSVKSFIDIADQNAKLRKENANLSSSLANQISSLQGCVDEARTRLNETSNRLNAVLKERETLATQLTTAKDKLAASEKEQGILKSKFEEERQGIEAEVREKEEELQRLGDFTVALKSVEGNEHDIRNALNAIFNAARSLADTYFGVNLPGDILADQTHWNEISAYNSNIPLPRSNSQLAKRMRVALVLSVMGQVLCKHIFQPTYLRDSPGIDNILKVLANKEPDLESHLRAVLLKTSNKIGIPDGSVSEAASQNVFDLLAPLVPEDKRKEFQTGLHRLCTMARKEWESIQTLEDLVVPELGFNRQSKRTYRWNSLPFDDPPSSSSASAPSQRTNGTTSSSQTKGAASAPGQANNSPAAVAQPRFDTAADITDGPAVWPAFLNLSYGGETLAAGFCLPLSLTKAAAEEEEQTAIPTPGSSSPRTHREQRVEERNMGTKRRRQSVAFANGQSDQGKVKGSFLSNGSGSGSRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GRI6</accession>
    <name>A0AAJ0GRI6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">T6SS Phospholipase effector Tle1-like catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_558718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720532.1">
        <property type="nucleotide sequence ID" value="XM_062870482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GRI6"/>
    <dbReference type="GeneID" id="87889311"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF16">
        <property type="entry name" value="DUF2235 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="1">
        <location>
            <begin position="11"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3304752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="469" mass="53072" checksum="F620747959F0732D" modified="2024-07-24" version="1">MAAPPSCGRETKTKSNINYLARMMGIDLEHGVTEYHSPQDGIHAKYFDGSGLGGDFMRYLWDGALATHAKEECSAVYDFIVQYSDWDHDRVSTEVWMFGISRGAYIVRSVAGMINNCGIIRDIPHKAKLIEDKMIYDIYRNPHPVHHPSSPEMRDFRDKASYAVRTPVKFMGLFDTVGSRGVPRLNYDSGTGFEWPEFYDACVSTAVEKVYHAVSIHDRFWGFQPCLASRAPPSKNNDNRATTITSTSNNNLKIRQKWFPGCHYDLARQEFQFLREGASWKERLVFWLLNPLSKTVWPNHKLADLALLWILQGIEREGGGALVRKELDGRTDSDIGAAIVQTRQRILHLAGDRKHLIGTGDVYDDILSYLPGGRLLSAPIRWAKRMNETAYAVLFKGVERVIPDPGIGTDAEDAPVWNEVYDYTVPDTDGLGALGVAAIRDLAGVNEKRYPSRTFQKYRVYMQTVQRQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GRU0</accession>
    <name>A0AAJ0GRU0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_256211</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720729.1">
        <property type="nucleotide sequence ID" value="XM_062863254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GRU0"/>
    <dbReference type="GeneID" id="87882083"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056693">
        <property type="entry name" value="DUF7791"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25053">
        <property type="entry name" value="DUF7791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="221"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7791" evidence="4">
        <location>
            <begin position="528"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="99"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3304949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="650" mass="74724" checksum="919AE4C21B469DF3" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GSN9</accession>
    <name>A0AAJ0GSN9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_197086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721217.1">
        <property type="nucleotide sequence ID" value="XM_062862528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GSN9"/>
    <dbReference type="GeneID" id="87881357"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3305437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="152" mass="17061" checksum="184E92A8E288FB8E" modified="2024-07-24" version="1">MQPLASSLRVKTHFPCELFLSEMLHDESTIEPAWCTLSENRKGNLLCPSRGPNMRSLGSHGSRGKGGEDIQTEDSNTTLTLPHMVKPCPRRASTEKKQRKKTYNTRHSLVVTDPTTTQALGSLTMGERTGSRVLYQVWSYVMVGMRESCLYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GT45</accession>
    <name>A0AAJ0GT45_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_203932</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721411.1">
        <property type="nucleotide sequence ID" value="XM_062862608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GT45"/>
    <dbReference type="GeneID" id="87881437"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01370">
        <property type="entry name" value="KISc_KIP3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000053">
        <property type="entry name" value="Kinesin family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF13">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF19 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="8">
        <location>
            <begin position="7"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="643"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="682"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="925"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="793"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="836"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="872"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="941"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="978"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="1063"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="133"/>
            <end position="140"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3305631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1086" mass="117573" checksum="22990A2355110A90" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GTV0</accession>
    <name>A0AAJ0GTV0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_502999</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721762.1">
        <property type="nucleotide sequence ID" value="XM_062867456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GTV0"/>
    <dbReference type="GeneID" id="87886285"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3305982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="333" mass="37585" checksum="19584C9C397E9FC3" modified="2024-07-24" version="1">MAACKLGGLPTEVLTTIFEFFCAHCRHDNVRDPYDEQTLVTLCQVSRYLRDVTQPILYHFFTSEVRTLGPSKGEDSVSNIYRKLLFLRSLVARHDLAEAVRSLHFVPQGRSWSLPSPSTLDDKLFNMSEDLFAEACGQLKIKNIQNVEHSDSFGNYTVIQLIIAHSPKCEFISLGPFSVSHRPPEQEDMWVFRRIVSPIPPAAPSPLDALRKLKEIRLYHEPRPVGNSLESLTLNLEFYGSPNVLKANSTLKAFKRLSFLKTDLDCFGGDMNAAADDLLVRVLPESLQNLTLAANHRQRNLQKQLQELSQSQHLFTELQHVSPLTSLEDGQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GUN2</accession>
    <name>A0AAJ0GUN2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_509831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722236.1">
        <property type="nucleotide sequence ID" value="XM_062867817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GUN2"/>
    <dbReference type="GeneID" id="87886646"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3306456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="211" mass="23194" checksum="EDC3837DCDE10969" modified="2024-07-24" version="1">MYIYGYTGLATQNTGFKNYHYTADADGNNDDNLQIGRSGARLEHGWINGQQVVLPPATAILRLFSMIPLFLPEEGLERSRKLVASRASLYAGAYGAFFSLFPFFTTYTFGPMLRITGIGPDPPVLQIPSNVALPRIRQCDSNGFEDLESGVWISGSLHNTTIGVGRVHPTKTSGYTMTTTPPPPPPPRITVDRQEVDAKGNRFIMVTEAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GUT7</accession>
    <name>A0AAJ0GUT7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ASTRA-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_501140</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the ASTRA complex involved in chromatin remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the ASTRA chromatin remodeling machinery complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat ASA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722254.1">
        <property type="nucleotide sequence ID" value="XM_062867394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GUT7"/>
    <dbReference type="GeneID" id="87886223"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854:SF1">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="14"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="460"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="250"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="394"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="273"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="291"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="412"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3306474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="475" mass="51556" checksum="61D4BCA461FAFAA1" modified="2024-07-24" version="1">MATEARPAQPKSILRGHKAQVHAAAFVRGNERLLTGDADGYVVAWDLTIMRPRAVWQAHANAILGIAGWGQNRLITHGRDNKLIVWKLSAEDESRLSTRLPLDPSPESRAQPWILHMLDVNTMNFCSFSHCPVSPECSATASEIFVAVPNTLASEAIDIFHLPSQTRRHTVKLGEKNGMVMAVSLLHQRDTLTLVAGYENGLATVAKLDSHGNWTVKYQAQCHSQPILSLDVCPGREFFLTSSADAIIAKHPLPTSPPSPSDETSIPPPPPSMTSSPSSKPNPAKSLLSAVLSSPDSSHPEPQQQTAAAKPSQREDIQTQPLKAVNTKHAGQQSLRIRSDGRIFATAGWDAKVRVYSTKTLAEVAVLKWHQVGCYATAFAEVVVVDSDDVASTSEALKEGEWEDGQGVGVQDEGRGGEEEEEGKEKGAGQGNKSLIPVPKLVEMTVREKRVRQVRTAHWLAAGSKDGKVSLWDVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GUW4</accession>
    <name>A0AAJ0GUW4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Diaminohydroxyphosphoribosylamino-pyrimidine deaminase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_492112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722356.1">
        <property type="nucleotide sequence ID" value="XM_062866842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GUW4"/>
    <dbReference type="GeneID" id="87885671"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF109">
        <property type="entry name" value="RIBOSOMAL LYSINE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3306576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="343" mass="36506" checksum="9E6DAE610A9A1F30" modified="2024-07-24" version="1">MKLEGLLQVLGTPVQSAEEETFELFAQDLPSQNLGFIDAKATTLELTVAGRDLTIHQSPAVLSSNRAGGTTGAVVWKITPLFAEWLTSPDNPLFTHGVLSGSSLVLELGCGISGLVALLLAPRIAGYVLTDQPYVAKLVEQNVSDNLHATSPAPAKTAVRPSRSRRTSSDRHPHPASVHRKAVANSSRARNGSRDRGGSGAGSEAARIRFTPLDWETDEATPALAGTGEAKSFDAVVACDCIYNEALIDPFVSTCVDLCRLRVNETATGTGTDAGTGAEPCVCVVAQQLRDPLVFEAWTARFARSFHTWRVPDELLVPGLRADSGFVVHVGVLKETINLEEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GV33</accession>
    <name>A0AAJ0GV33_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Deoxyhypusine hydroxylase</fullName>
            <shortName evidence="9">DOHH</shortName>
            <ecNumber evidence="9">1.14.99.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Deoxyhypusine dioxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Deoxyhypusine monooxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LIA1</name>
        <name evidence="10" type="ORF">B0T15DRAFT_527956</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>[eIF5A protein]-deoxyhypusine + AH2 + O2 = [eIF5A protein]-hypusine + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:14101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="Rhea" id="RHEA-COMP:12592"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="ChEBI" id="CHEBI:91175"/>
            <dbReference type="EC" id="1.14.99.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="9">Binds 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the deoxyhypusine hydroxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.29" evidence="9"/>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GV33"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019135">
        <property type="term" value="F:deoxyhypusine monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03101">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027517">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697:SF5">
        <property type="entry name" value="DEOXYHYPUSINE HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697">
        <property type="entry name" value="PBS LYASE HEAT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 9" id="KW-0386">Hypusine biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3306681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="336" mass="36082" checksum="3352068DCB48C69B" modified="2024-07-24" version="1">MTASTATPADSSTLAKIASLRQTLVSETTPLAVRFRALFSLKHLARQNPADSAESLAAIDAIAASFTSSSALLKHELAYCLGQTGNSAAIPYLTAVLENVGEDSMCRHEAAEALGALGDKASLDVLRRFKEREGEEVVVTETCEIAIDRIEWENGEGRKGERLRQSDFASVDPAPPMAQGQQEPTVEELGKTLMDTSLPLFKRYRAMFALRDLASPPDLPTAVPAVHALAKGFADSSALFRHEIAFVFGQLAHPASIPALTAALSNTEEASMVRHEAAEALGSLGDEDGVEETLKKFLHDKEAVVRESVIVALDMAEYEKSNQTEYALIPEVEGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GV88</accession>
    <name>A0AAJ0GV88_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_142178</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722260.1">
        <property type="nucleotide sequence ID" value="XM_062861887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GV88"/>
    <dbReference type="GeneID" id="87880716"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3306480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="300" mass="30801" checksum="76A05BAD82731086" modified="2024-07-24" version="1">MAAMSVYSEVKRLHTSLQELVGLRRRKRQLQISEPFNFRKETAVVPGLTEDEISVLREKAAASRLGIAHPDDTDDTIPVPATILPRPGSRRRLSSLPLHASSPPPRLSIPIPIPIPNANGKRHAFVGSAGGYSYSSLRSSRTTGMAQGMGLDRGEMVQVVLVPVPEGGGGPGITMRPSASVNDLDLLLFGNPSGVGRDTTTTTAGTGTGTGSALLLLSPVSAAAASTSASSSVSISPLDLTYGSSGGGGGASTGATSVTERSSDLMLEMDFEFQLGSPVSPLSPSPAGSVAVGKKGLLVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GV91</accession>
    <name>A0AAJ0GV91_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_566349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722405.1">
        <property type="nucleotide sequence ID" value="XM_062870695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GV91"/>
    <dbReference type="GeneID" id="87889524"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3306625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="258" mass="29607" checksum="04A21E0066CFCFE5" modified="2024-07-24" version="1">MASVASRPPPAQGGTMRFTNVRDLFNAIDYTARDSLTVRSIVSPCHFYIIRTRERQRRKFRFRYYDSDSRILIITIPTDSHEQLNKELYNDATRSVQQGYSGRRSKEGDSAGGPKPERATKGAWPTLVIEAGVSETLTQLRLDMRRWFDMSNYEVKIVLLAKFDGTKILLEKWEEEMRVRPGATTTRRSLQHQESVLRQSITITQDTTTDPTSYHVTSGALVPSFRFLFLREPGPGKGDFVIGVQELEEYAENIWSVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GVG0</accession>
    <name>A0AAJ0GVG0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_484142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722678.1">
        <property type="nucleotide sequence ID" value="XM_062866209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GVG0"/>
    <dbReference type="GeneID" id="87885038"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3306898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="359" mass="39402" checksum="36ECF4F9918427B7" modified="2024-07-24" version="1">MLTTLTVGGALAKRLVQDPPTGGTLLPSWIGWLFLGDVVLFLPILFVIGYTFGRVFPALAAVEDPLPAYEAVPLNDDDTPKDDNDPVHPGKPVTASIRATHRLLRSVGGWLSYFRGFGYAVAINIMTIMIIVPFYHLLPIIPIRVVHLFALYILTPWYVAWTHVVITPESNTSFLRRLVPFRRAFVATWFPTFLFWAATHVCLILPSLLAGAIGLDIELRNPLNLGPVVTNVDVGKSLCVIGVLVALQALLLIPAHTALVRVQASLLPADQDTIVPFDRSFGGLVAPEVVTGKGFASFTAALTTVSRASWLRIYLLRLKVFATLVAMYVVLIATVVLQVYLFSVKCEYGKDRLNPLKCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GWE2</accession>
    <name>A0AAJ0GWE2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase M3A/M3B catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_395783</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase M3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723097.1">
        <property type="nucleotide sequence ID" value="XM_062864798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GWE2"/>
    <dbReference type="GeneID" id="87883627"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06455">
        <property type="entry name" value="M3A_TOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000074">
        <property type="entry name" value="Metalloprotease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.40">
        <property type="entry name" value="Endopeptidase. Chain P, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024080">
        <property type="entry name" value="Neurolysin/TOP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF84">
        <property type="entry name" value="SACCHAROLYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="8">
        <location>
            <begin position="246"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3307317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="722" mass="81915" checksum="D64444A47907B145" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GWI1</accession>
    <name>A0AAJ0GWI1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_492897</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723198.1">
        <property type="nucleotide sequence ID" value="XM_062866893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GWI1"/>
    <dbReference type="GeneID" id="87885722"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.30:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerases II, IV and V subunit 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.30">
        <property type="entry name" value="RNA polymerase ii, chain L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006591">
        <property type="entry name" value="RNAP_P/RPABC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039747">
        <property type="entry name" value="RPABC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12056">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12056:SF2">
        <property type="entry name" value="GEO11084P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03604">
        <property type="entry name" value="Zn_ribbon_RPAB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00659">
        <property type="entry name" value="RPOLCX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="RNA polymerase subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3307418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="79" mass="8733" checksum="CF6F5D33F3CDF513" modified="2024-07-24" version="1">MSREQYQVPSGSPTTDGSAFKVATRDYVGGSGDNTMHYLCGDCAARVPLDKGAPIRCQRCGGRVLYKERTKRMVQFEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GXG6</accession>
    <name>A0AAJ0GXG6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chloroperoxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_433391</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723445.1">
        <property type="nucleotide sequence ID" value="XM_062865770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GXG6"/>
    <dbReference type="GeneID" id="87884599"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF19">
        <property type="entry name" value="HEME HALOPEROXIDASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042468166" evidence="8">
        <location>
            <begin position="18"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="9">
        <location>
            <begin position="22"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3307665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="264" mass="28950" checksum="968FBFD4810E1A0C" modified="2024-07-24" version="1">MKLSVFVEAGLLGLAAALREPKGHEYHRNPLDSRSPCPGLNALANHGYLPRSGLNIDLETLRYAIVAGFNFERTSQDGAFNMAIAFNLSTSGNSSTFHLDDLKLHDAIEFDGSLSRNDFYLGDDLHFDPVIWHTVAVNLDLYRTGPSEKDKYVTVEVAARAAAARAKAAKAANKHFNASAAQMVGSPGTTALYLTTLWDDDAGAAPKSWIKALFEEERIPFREGYNPATRKQKTGQDIGDMFARVMAAYTDVSKGRRGLRWGSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GXQ1</accession>
    <name>A0AAJ0GXQ1_9PEZI</name>
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        <submittedName>
            <fullName evidence="4">Up-regulated during septation-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_490643</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723817.1">
        <property type="nucleotide sequence ID" value="XM_062866696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GXQ1"/>
    <dbReference type="GeneID" id="87885525"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029191">
        <property type="entry name" value="Uds1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15456">
        <property type="entry name" value="Uds1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="351"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="75"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="119"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="618"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="431"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="203"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
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            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
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            <end position="520"/>
        </location>
    </feature>
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            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="643"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3308037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="668" mass="73199" checksum="269C1DFD87E7EE57" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GY66</accession>
    <name>A0AAJ0GY66_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_490921</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724113.1">
        <property type="nucleotide sequence ID" value="XM_062866734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GY66"/>
    <dbReference type="GeneID" id="87885563"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3308333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="163" mass="17908" checksum="E14BF067E5813204" modified="2024-07-24" version="1">MLAANYKHEENAEITRRDPSPWDGDMDILLLKLVDREKAIFERISHANSWLSALKEIMPFNFSFSSSASAVVVGSASANGHGAIKGWAYKHEAYSNNDGSGVRTTKQKLGEPPVTQTRMYDAQGRPLLTDGAGRRTGLDDSVRRIEDVTEDRPSTGSVKVAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GYX7</accession>
    <name>A0AAJ0GYX7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_392565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
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                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
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        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
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                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
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                <person name="Martin F."/>
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                <person name="Natvig D."/>
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                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
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                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
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        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <person name="Labutti K."/>
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                <person name="Gladieux P."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN SPT21"/>
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    </dbReference>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Kuo A."/>
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                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
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                <person name="Chen C."/>
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                <person name="Ng V."/>
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                <person name="Grigoriev I.V."/>
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        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <person name="Hensen N."/>
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                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
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                <person name="Thoren M.H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3309131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="729" mass="82056" checksum="45E52121773ACD81" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GZQ0</accession>
    <name>A0AAJ0GZQ0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_509508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3309119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724899.1">
        <property type="nucleotide sequence ID" value="XM_062867793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GZQ0"/>
    <dbReference type="GeneID" id="87886622"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3309119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="135" mass="14609" checksum="535198A759F1D5F6" modified="2024-07-24" version="1">MARPFLFPGFVSWTCMQHAQRITVLALVGSLTDAAFARACGAVHGSLCGDLLCIPWLIIQQHSSPEPSPLARVEPPLKRGHDREDGLARDSSARGAISPRNGPTASQTFLALHKRQPTASKERFRPAAAEKPFPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GZQ2</accession>
    <name>A0AAJ0GZQ2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Isoprenoid synthase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_483560</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3309127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724907.1">
        <property type="nucleotide sequence ID" value="XM_062866169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GZQ2"/>
    <dbReference type="GeneID" id="87884998"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046165">
        <property type="term" value="P:alcohol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF44">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="44"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3309127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="404" mass="44641" checksum="43DFF093EABEBA4A" modified="2024-07-24" version="1">MDIVWPGTGLLHDSRQPRAAIRSPSPIPPRTSSTQSTAAGALWSGPGASLPSGSATAGPAHKRQRSRKASAGATSFPFMSTAMSAPAQPPPDPNRFATEDFILTARRPWSEEKDKVLTGPFDYLNGHPGKDFRSALVKAFDAFLEVAPESLEVITKVVSMLHTASLLVDDVEDNSQLRRGFPVAHAIFGIPQTINSSNYVYFCALQELQKLKNPKVISIFTEELLNLHRGQGMDLFWRDTLTCPTEDDYLEMVGNKTGGLFRLGIKLMQAESRSLVDCVPLVNIIGLIFQIADDYHNLFSKQYTANKGMCEDLTEGKFSFPVIHSIRSNPGDMQLLNILRQKTEDVEVKRYAVAYMQSTGSVEYTKKVLAVLIERARRMADELDEGRGRAQGVHGILDRMVVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GZU4</accession>
    <name>A0AAJ0GZU4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Corticosteroid-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_133737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3309208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724988.1">
        <property type="nucleotide sequence ID" value="XM_062861781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GZU4"/>
    <dbReference type="GeneID" id="87880610"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3309208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="373" mass="41261" checksum="9B38A553D2D7E343" modified="2024-07-24" version="1">MDLPARRPRPAVHAFSFRYLLVVPVLLSILTGYVLFIHSDTNIYMLYSQCHARSRIPWLSDIPLLGSPACFLVSFFQEAIASARAFGLMAVILSFFASLLTVSTIEAARICNSPSMLIAYPTGAWLVFNLIGGAIVWELVIIPAFVHRSREIIAARKQGGPQQLSGLADPTFGETMRHLARVAETLAIPVAVAIGYVVPSLLMLVLDAPMAVLAWLFFPVWVSLVRQTVRRVVLWLREEWNVSLHLESNRPALLAVYFLPIACSVLAHAHFIWTMTQPDDRKEMTRATLKFITIDAFFVGLTVLYWVFIEAGWKVALVMVGGSVLLGPGAGVCIGWIYREQMVDLDRSVTVVVVGAQRDNGGASPSEQTPLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GZV8</accession>
    <name>A0AAJ0GZV8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_131931</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3309162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724942.1">
        <property type="nucleotide sequence ID" value="XM_062861754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GZV8"/>
    <dbReference type="GeneID" id="87880583"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000165">
        <property type="term" value="P:MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06620">
        <property type="entry name" value="PKc_Byr1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000253">
        <property type="entry name" value="MAP kinase kinase Ste7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000261">
        <property type="entry name" value="MAP kinase kinase Ste7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049613">
        <property type="entry name" value="Byr1-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050915">
        <property type="entry name" value="MAP_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE STE7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="65"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="354"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="362"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3309162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="415" mass="46237" checksum="9AA16C435AF1F627" modified="2024-07-24" version="1">MADAFAPRSMKRKNVKGLALKAPAPKPPPTAENARLGPAHGKGDDNAAQLEIGIEFNLDLKPEDLEIIKDLGAGNGGTVSKVKHIPTNTVMARKIIHVEAKKEMRKRIVRELQIMHGCHSDYIVTFYGAFLNENNDVIMCMEYMDVGSLDRISRVFGPVRVDVLGKIAEATLGGLTYLYSKHHIMHRDIKPSNILVNSRGHIKLCDFGVSGELINSVADTFVGTSTYMAPERIQGEKYTVKSDVWSFGLTIMELAIGKFPFAASEQLSDAESAPAGILDLLQQIVHEPAPQLPKSDAFPQILEDMIQKCLYKEPERRPTPQELYDRDLFVQAAKRTPVDLREWACGLMDRDNRKSHLAPQLSPATQDLLRTSDSPTYGTQATPTSNYRVDPRQAADHANLAAQVDRLYIREWDHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H0X5</accession>
    <name>A0AAJ0H0X5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_14714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725583.1">
        <property type="nucleotide sequence ID" value="XM_062861946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H0X5"/>
    <dbReference type="GeneID" id="87880775"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3309803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="229" mass="25120" checksum="982F2B2410BF2C75" modified="2024-07-24" version="1">MTMSWHCRHTSTSTSTPHASYPSVGAAVESMNLKQSGGGTQQSHAAMLAHNHIGLNRTPVQSEPRPGKRAGAHWVKLHLCCAADAMQSAAPFRPATFQENGLATQKGKFSCLSAQDLTQPHGARPFEVRQPKCAWGVGHPRSSELKWGFDRLNSNFHSIQSSIRLPETRRGSKPAPGAISFAHVSRPDLPILTRKNSSYLVKQWMPDGWLPRYLLASQTHNKTDLVVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H1F5</accession>
    <name>A0AAJ0H1F5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Retinol dehydrogenase 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_517174</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725808.1">
        <property type="nucleotide sequence ID" value="XM_062868301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H1F5"/>
    <dbReference type="GeneID" id="87887130"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF283">
        <property type="entry name" value="RETINOL DEHYDROGENASE 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3310028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="322" mass="34680" checksum="4916149F98B43122" modified="2024-07-24" version="1">MSPFNFHTTGEEVVSAWPEHIKGRTFLITGPSNKSLAAGAAIDLAKKAPEHIILVGRNKAKIDPVVEQIRSVGAGVQVTFVQCDLSDHDSVRKAADEINANGAIQKIDVVINCAGVMNIHDYTLDKQGIEMTFSACHVGHFLLTNLILPKVLAAGKGARIINVTSVGHTIGPVRFDDPNFSAGAAYDPWSAYGQAKTANILYSVELSRRLADRGVVSNAPHPGGIAETGLVRDTEMHEFDAIGPIAVRNTGREFRLDHPFKTIDGGVSSILAAALDPGFADKPGIYIRDCQPQTPYEYAADPEAAKRLWALSEQLVGQKFDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H212</accession>
    <name>A0AAJ0H212_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">tRNA-dihydrouridine synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0T15DRAFT_387945</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs. Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="8">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="9">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725860.1">
        <property type="nucleotide sequence ID" value="XM_062864415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H212"/>
    <dbReference type="GeneID" id="87883244"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052582">
        <property type="entry name" value="tRNA-DUS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45936">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45936:SF1">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="11">
        <location>
            <begin position="119"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="383"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="430"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3310080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="444" mass="48163" checksum="265276FDF7C365B0" modified="2024-07-24" version="1">MATAEETAATTATTNGISPTPSPAPTDLPRVPIPPRGVDYRGKLVLAPMVRSGELPSRLLALHYGADLVWGPETIDHALIGATRRVNPRTGMIEYTRQPSHSNSPAYVNANGNPESVIYRLDPVREKNKLVFQLGTSDPARAVAAARFVAADVAGIDVNAGCPKPFSVSGGMGAALLRTPEKLAGILEALAREIAPQFQIGISVKIRLLETAAETEALVSRLVRTGITGLTVHCRTTPMRPRERAIRGQLAMIARVCREAGVACLMNGDVECRDQAEKLVKEFGTDGAMIATAAEKNPSCFRTAEQGGLASWQETVEKYLRFAMEVENKMGNTKYLLTQMVPGRAPVYKQMHPCKSYSDLVQLFGHDELKEMARETDRVLGLGEFEVKPEPKQKQKNKQKQGGGDQEASKKRKWEDEQAEEQSAKRVAEMPEPASVAAPASVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H2C7</accession>
    <name>A0AAJ0H2C7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Insertion element IS150 protein InsJ-like helix-turn-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_518692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726286.1">
        <property type="nucleotide sequence ID" value="XM_062868385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H2C7"/>
    <dbReference type="GeneID" id="87887214"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055247">
        <property type="entry name" value="InsJ-like_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13518">
        <property type="entry name" value="HTH_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Insertion element IS150 protein InsJ-like helix-turn-helix" evidence="1">
        <location>
            <begin position="26"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3310506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="94" mass="10227" checksum="424526BF20AD2BD3" modified="2024-07-24" version="1">MVNLAEIGAKLTAGRQPGQELSPTARAAIIGAVAAGASQSAVACAFRIDRTAVYRILQRFESSTTVKSKPRTGRPEILTCREKRYILQLAKRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H2I4</accession>
    <name>A0AAJ0H2I4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0T15DRAFT_507280</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PGA52 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="3"/>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726409.1">
        <property type="nucleotide sequence ID" value="XM_062867636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H2I4"/>
    <dbReference type="GeneID" id="87886465"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018805">
        <property type="entry name" value="YJL171C/Tos1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018807">
        <property type="entry name" value="YJL171C/Tos1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31737">
        <property type="entry name" value="PROTEIN TOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31737:SF2">
        <property type="entry name" value="PROTEIN TOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10287">
        <property type="entry name" value="YJL171C_Tos1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10290">
        <property type="entry name" value="YJL171C_Tos1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042538141" description="glucan endo-1,3-beta-D-glucosidase" evidence="9">
        <location>
            <begin position="21"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="Cell wall protein YJL171C/Tos1 N-terminal" evidence="11">
        <location>
            <begin position="29"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Cell wall protein YJL171C/Tos1 C-terminal" evidence="10">
        <location>
            <begin position="292"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="203"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="258"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="474"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="204"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="270"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3310629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="538" mass="57416" checksum="9C0FB88F4BA5D387" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H2J3</accession>
    <name>A0AAJ0H2J3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_518972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726408.1">
        <property type="nucleotide sequence ID" value="XM_062868407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H2J3"/>
    <dbReference type="GeneID" id="87887236"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3310628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="263" mass="28844" checksum="591E80E951190909" modified="2024-07-24" version="1">MRCQNRGEVANLLQPPRSISSSGRVIYNRANYNFTHYLPRQGPGRRRGVRWEEEQWGVSKSTIEFREAAGTMDPLWVGVWASVCLGIFRFARDAENGRFWAVIERLAKAEAEEERTGVVGKGRYDLVSLLFDWGLFAEGLYLEKKLKKVDDDEEGSEAGRFWFPCRVLDPNANGGPTGYSDFVLVETSPTPEAGFAGWGSSDDGPATAAAAAQTGFSGAETWERDVAAALSGWTVTRDGQPVADSGGSSDFVHSPPPQNGLDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H2X1</accession>
    <name>A0AAJ0H2X1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_42065</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726339.1">
        <property type="nucleotide sequence ID" value="XM_062865542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H2X1"/>
    <dbReference type="GeneID" id="87884371"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000031">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="181"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3310559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="342" mass="38615" checksum="4338FC2460F544FD" modified="2024-07-24" version="1">MPVIKGHDVIAQAQSGTGKTATFSISVLQKIDPSLKQCQALILAPTRELAQQIQKVVVAIGDFMNIECHACIGGTSVRDDMKALQDGPQVVVGTPGRVQDMIQRRFLKTDGMKMFVLDEADEMLSRGFTEQIYDIFQLLPQSTQVVLLSATMPQDVLEVTTKFMRDPVRILVKKDELTLEGIKQFYIAVEKEDWKLDTLSDLYETVTITQAVIFCNTRRKVDWLTEKLTARDFTVSAMHGDMDQAQRDLIMKEFRSGSSRVLIATDLLARGIDVQQVSLVINYDLPANRENYIHRIGRGGRFGRKGVAINFVTAEDVRMMREIEQFYSTQIEEMPMNVADLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H391</accession>
    <name>A0AAJ0H391_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_59501</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726812.1">
        <property type="nucleotide sequence ID" value="XM_062871110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H391"/>
    <dbReference type="GeneID" id="87889939"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF4">
        <property type="entry name" value="CONIDIAL DEVELOPMENT PROTEIN FLUFFY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="72"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="204"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3311032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="824" mass="90553" checksum="16BF08446F3181D6" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H3L2</accession>
    <name>A0AAJ0H3L2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">UAA transporter family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_65543</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726961.1">
        <property type="nucleotide sequence ID" value="XM_062871157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H3L2"/>
    <dbReference type="GeneID" id="87889986"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005462">
        <property type="term" value="F:UDP-N-acetylglucosamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005464">
        <property type="term" value="F:UDP-xylose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF4">
        <property type="entry name" value="NUCLEOTIDE SUGAR TRANSPORTER SLC35B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3311181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="420" mass="45757" checksum="46609F130938CDD0" modified="2024-07-24" version="1">MTTRRRPALHKHQQTPPTSKDRGDKTYAMSAPSPRVINAGPSLEKAEMYGIDDNRPVFSRAMALAGRMFIETIPQWLAVGAMLSLIFGGCCSNVFALESIIKVEPASGTLLTFVQFLFVAAIGLPSQFDSKRPPFFLKPNKVPIRRWLVNIVLFFSINVLNNHAFSYDISVPVHIILRSGGSITTMIAGSLYGKKYSRIQVVAVLLLTVGVITAAWSDAQTKGSPADKSVGNASFGTGLAILFVAQVLSAIMGLYTEETYRIYGPQWKENLFYSHLLSLPLFLPFLPSLTRQFMKLANSAPLSLAVPSPEDLPAISPNIQRGLQKIQIPSQLFYLVLNVLTQYACIRGVNLLAAASSALTVTIVLNIRKLVSLLLSIWLFGNRLASGTLIGAVIVFFAGGLYSLDGKRKLPVRRGAAAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H3M0</accession>
    <name>A0AAJ0H3M0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_520726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726966.1">
        <property type="nucleotide sequence ID" value="XM_062868521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H3M0"/>
    <dbReference type="GeneID" id="87887350"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="416"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3311186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="596" mass="66121" checksum="F9D7B8B41AB19608" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H3P6</accession>
    <name>A0AAJ0H3P6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ER membrane protein complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0T15DRAFT_571400</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726710.1">
        <property type="nucleotide sequence ID" value="XM_062870856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H3P6"/>
    <dbReference type="GeneID" id="87889685"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058545">
        <property type="entry name" value="Beta-prop_EMC1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026895">
        <property type="entry name" value="EMC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011678">
        <property type="entry name" value="EMC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21573">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21573:SF0">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25293">
        <property type="entry name" value="Beta-prop_EMC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07774">
        <property type="entry name" value="EMC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042578738" description="ER membrane protein complex subunit 1" evidence="13">
        <location>
            <begin position="27"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="986"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="domain" description="EMC1 first beta-propeller" evidence="15">
        <location>
            <begin position="26"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="ER membrane protein complex subunit 1 C-terminal" evidence="14">
        <location>
            <begin position="785"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="96"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF25293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3310930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1019" mass="110319" checksum="829BE98B906AF267" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H3S5</accession>
    <name>A0AAJ0H3S5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">glutathione-specific gamma-glutamylcyclotransferase</fullName>
            <ecNumber evidence="1">4.3.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_521021</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.7" evidence="1"/>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727088.1">
        <property type="nucleotide sequence ID" value="XM_062868540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H3S5"/>
    <dbReference type="GeneID" id="87887369"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061928">
        <property type="term" value="F:glutathione specific gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.490.10:FF:000021">
        <property type="entry name" value="Gamma-glutamylcyclotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006840">
        <property type="entry name" value="ChaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12192">
        <property type="entry name" value="CATION TRANSPORT PROTEIN CHAC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12192:SF2">
        <property type="entry name" value="GLUTATHIONE-SPECIFIC GAMMA-GLUTAMYLCYCLOTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04752">
        <property type="entry name" value="ChaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="244"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="244"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3311308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="270" mass="31141" checksum="325EA546930EE666" modified="2024-07-24" version="1">MSGQSPPSQADEFWLFGYGSLIWKPPPHFDRRIPGWVTGYVRRFWQASEDHRGTPQAPGRVVTLISRSYWDQLTDHHDSAPEKVWGVAYRIKPDRVAEVKEYLDIREINGYTIHYTPFHPAPGVDPALLPQHCPFQTLVYIGTPDNEQFVGPQDPQKLAEHIYRSEGPSGLNRDYLWGLERALDELSPDSGDEHVTDLSTRVRALAAREEEKMKKTGEIRTEKEGILRPLYPVSVSPEWVLERERQHHGQHHDFRKVSSIDEQEETEKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H483</accession>
    <name>A0AAJ0H483_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_571854</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727281.1">
        <property type="nucleotide sequence ID" value="XM_062870872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H483"/>
    <dbReference type="GeneID" id="87889701"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3311501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="261" mass="29441" checksum="0716D57DF6090AAE" modified="2024-07-24" version="1">MALLYGDLDDEIDYIFSQASAPRAECDDWARTICTVVAGLNREKIVQFRNMNVQLDMRMLDLARQIHGKVVPVGAALGQIGDDGQRQLAIYEMDRLPGDNYAMVRTSLAEVPQSQLAAVHSLARFFAQAWRRPVALDRDLNELNILVDGRSGIITRVIDWTDAGIQPFGLTLYALEKFIGSMGRDGWVFFDNAGALRDEFWRAFTLYPGQVSYSQMRIIQAARKAGYLLRYGTFYSTGQKGVVGIENMSIEKRRLYLQAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LXV6</accession>
    <name>A0AAJ0LXV6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_544539</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717537.1">
        <property type="nucleotide sequence ID" value="XM_062870091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LXV6"/>
    <dbReference type="GeneID" id="87888920"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF12">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="128"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3301757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="715" mass="80070" checksum="889E1E378D12B467" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LY25</accession>
    <name>A0AAJ0LY25_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_544941</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717674.1">
        <property type="nucleotide sequence ID" value="XM_062870112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LY25"/>
    <dbReference type="GeneID" id="87888941"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3301894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="234" mass="25857" checksum="BD3FFBBA6A02055F" modified="2024-07-24" version="1">MRLGGVPLVDLQHCSTEDDEEVVAQDMKKNKGDKALTMKKHIVAAEAEPPWERDGSLINISTQGDPLDRKLLDRLLLVGSPECKVKQPAPCSCRTKEECRQALQCSCRRIPIPSIVRTVIKKPLRDDCLVAEEACLIAWQLQAVGLLVDGVEAVAATVDDGVHIESRPGNTAEGFARKEGESRMLGASLIEYVRSKVCKDIICIILQFWPVSASTLRSHPRVVNQDPLERGRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LYF5</accession>
    <name>A0AAJ0LYF5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_302104</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718122.1">
        <property type="nucleotide sequence ID" value="XM_062863823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LYF5"/>
    <dbReference type="GeneID" id="87882652"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02413">
        <property type="entry name" value="KH-II_40S_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1140.32:FF:000004">
        <property type="entry name" value="40S ribosomal protein S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.20:FF:000006">
        <property type="entry name" value="40S ribosomal protein S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="entry name" value="Ribosomal protein S3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057258">
        <property type="entry name" value="Ribosomal_uS3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_uS3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018280">
        <property type="entry name" value="Ribosomal_uS3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005703">
        <property type="entry name" value="Ribosomal_uS3_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003219">
        <property type="entry name" value="PRK04191.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01008">
        <property type="entry name" value="uS3_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760:SF32">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="Prokaryotic type KH domain (KH-domain type II)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="Ribosomal protein S3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00548">
        <property type="entry name" value="RIBOSOMAL_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="KH type-2" evidence="9">
        <location>
            <begin position="24"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="217"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="249"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3302342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="260" mass="28516" checksum="DE82B535D409427E" modified="2024-07-24" version="1">MAVPGTQISKRRKFVADGVFYAELNEFFQRELAEEGYSGVEVRVTPTVTDIIIRATHTQEVLGEQGRRIRELTSLIQKRFKFPENSVSLYAAKVQNRGLSAVAQCESLRYKLLNGLAVRRACYGVLRFIMESGAKGCEVVVSGKLRAARAKSMKFTDGFMIHSGQPAKDFIDSATRHVLLRQGVLGIKVKIMRGSDPEGKAGPQKTLPDAVHIIEPKEETPVVQPMSQDYGAKAAAAQAAAEAARQEEQVGEEEPAPAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LYI6</accession>
    <name>A0AAJ0LYI6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YMC020W-like alpha/beta hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_300365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718078.1">
        <property type="nucleotide sequence ID" value="XM_062863806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LYI6"/>
    <dbReference type="GeneID" id="87882635"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058934">
        <property type="entry name" value="YMC020W-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058933">
        <property type="entry name" value="YMC020W-like_ab_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47349:SF1">
        <property type="entry name" value="AER328WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47349">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26147">
        <property type="entry name" value="AB_HYDROLASE_YMC0-YMC35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YMC020W-like alpha/beta hydrolase" evidence="2">
        <location>
            <begin position="516"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="328"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="404"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="461"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3302298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="918" mass="98671" checksum="CB5EC886883F30EC" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LYN4</accession>
    <name>A0AAJ0LYN4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DMAP1-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_441033</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Sordariomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_062865913.1"/>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Cros-Aarteil S."/>
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                <person name="Kuo A."/>
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                <person name="Riley R."/>
                <person name="LaButti K."/>
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                <person name="Lipzen A."/>
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                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 333.67</strain>
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        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
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                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Guillou S."/>
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                <person name="Lipzen A."/>
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                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718887.1">
        <property type="nucleotide sequence ID" value="XM_062869720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZ60"/>
    <dbReference type="GeneID" id="87888549"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045290">
        <property type="term" value="F:D-arabinose 1-dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070485">
        <property type="term" value="P:dehydro-D-arabinono-1,4-lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42686">
        <property type="entry name" value="GH17980P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42686:SF1">
        <property type="entry name" value="GH17980P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="31"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3303107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="454" mass="49068" checksum="A35E03EBBE3C5A1A" modified="2024-07-24" version="1">MAEPSEPAASSAAAKAEPMSSRPPLHTVLPPLVLGTATFNQQYVPDPHSMPYHDIVARALSLGVNGFDTSPYYGPSETLLGNALEGLMHPDASESNPNPVVPLQRSSFFLVTKAGRIASSEFDYSPSWVRYSILRSLQRLHTRYLDLVYMHDVEFVSGAEVLAAVRELRRLRDEEGVVRYVGISGFPVEVLCELAEMIFAETGEPLDAVLSYGHFTVQNRRLGLPWVEEEEEGGRGASGREGSPLARLKSAGVDVVLNASMLGMGLLTSKGIPADPQSNVETGETASPVAQWHPSPPELRRACKKLAEAAAEAGERLESVAIRWSLAEWARIGAVAGFGVDVLVPGGGSCKVGTTVCGVSSVAELEETVAEWRGALESLGQPGKNSDEAYGLARQEKVLHLVRKVLWPALGSWLDYVWESPKPGYVNARRESERGVVPDDGVVAAYEQARQKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZT2</accession>
    <name>A0AAJ0LZT2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_541199</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719547.1">
        <property type="nucleotide sequence ID" value="XM_062869840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZT2"/>
    <dbReference type="GeneID" id="87888669"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13384">
        <property type="entry name" value="HTH_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3303767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="98" mass="10716" checksum="8AD14318DA2DE91A" modified="2024-07-24" version="1">MVNLAEIGAKLTAGRQPGQELSPTARAAIIGAVAAGASQSAIARAFRIDRTAVYHILQRFESSTTVESKPRIGRPEILTCREKRYNLQLAKRRPQLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M036</accession>
    <name>A0AAJ0M036_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Threonine synthase</fullName>
            <ecNumber evidence="5">4.2.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0T15DRAFT_512242</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-homoserine + H2O = L-threonine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10840"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.2.3.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:10841"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the threonine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="5"/>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719819.1">
        <property type="nucleotide sequence ID" value="XM_062867965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M036"/>
    <dbReference type="GeneID" id="87886794"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01560">
        <property type="entry name" value="Thr-synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000046">
        <property type="entry name" value="THR4p Threonine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1380.10:FF:000003">
        <property type="entry name" value="THR4p Threonine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1380.10">
        <property type="entry name" value="Threonine synthase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029144">
        <property type="entry name" value="Thr_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037158">
        <property type="entry name" value="Thr_synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051166">
        <property type="entry name" value="Threonine_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42690">
        <property type="entry name" value="THREONINE SYNTHASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42690:SF1">
        <property type="entry name" value="THREONINE SYNTHASE-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24857">
        <property type="entry name" value="THR4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14821">
        <property type="entry name" value="Thr_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Threonine synthase N-terminal" evidence="15">
        <location>
            <begin position="20"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="14">
        <location>
            <begin position="106"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="12">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR604450-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF14821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3304039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="548" mass="60874" checksum="5586A9E4AB994098" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M0G7</accession>
    <name>A0AAJ0M0G7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_536509</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720225.1">
        <property type="nucleotide sequence ID" value="XM_062869556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M0G7"/>
    <dbReference type="GeneID" id="87888385"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13384">
        <property type="entry name" value="HTH_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3304445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="94" mass="10326" checksum="F29B7816000023B2" modified="2024-07-24" version="1">MVNLAEIGAKLTAGRQPGQELLPTARAAIIGAVAAGASQSAIARAFRIDRTAVYRILQRFESSTTVESKPRIGRLEILICREKRYILQLAKRHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M0L8</accession>
    <name>A0AAJ0M0L8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Replication factor C subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0T15DRAFT_537059</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the activator 1 large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720386.1">
        <property type="nucleotide sequence ID" value="XM_062869593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M0L8"/>
    <dbReference type="GeneID" id="87888422"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17752">
        <property type="entry name" value="BRCT_RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000021">
        <property type="entry name" value="Replication factor C subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000005">
        <property type="entry name" value="Replication factor C subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000001">
        <property type="entry name" value="Replication factor C subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000395">
        <property type="entry name" value="Replication factor C subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
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        <property type="entry name" value="DNA_replication_fac_RFC1_C"/>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="RFC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389:SF6">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25361">
        <property type="entry name" value="AAA_lid_RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08519">
        <property type="entry name" value="RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="12">
        <location>
            <begin position="296"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="381"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="957"/>
            <end position="1034"/>
        </location>
    </feature>
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        <location>
            <begin position="142"/>
            <end position="156"/>
        </location>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
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            <begin position="228"/>
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        </location>
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            <begin position="238"/>
            <end position="248"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="387"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="957"/>
            <end position="978"/>
        </location>
    </feature>
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        <location>
            <begin position="987"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1018"/>
            <end position="1034"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00020401"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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            <dbReference type="ARBA" id="ARBA00022840"/>
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        <source>
            <dbReference type="PIRNR" id="PIRNR036578"/>
        </source>
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        <source>
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        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3304606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1034" mass="113489" checksum="B6A75F03EFFB3874" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M0U3</accession>
    <name>A0AAJ0M0U3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fungal N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_568534</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062870768.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87889597"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3304831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="16513" checksum="ED7353B9B304A549" modified="2024-07-24" version="1">MDPFSITASVVGIVAPTLHCVRHLVKDLQNIADAPDTLTALTNDLQSVGLAFASVQAVTDSQWKSLGEAVTVQSKAAIISCKTSYERFKTFLERWTRHSTDGTLSQGHIKSISEQLQNCSITLTSMASIATFSSGPATATSGNAEAIQNNHFLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M148</accession>
    <name>A0AAJ0M148_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Helicase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_502235</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720823.1">
        <property type="nucleotide sequence ID" value="XM_062867424.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87886253"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001039">
        <property type="entry name" value="ATP-dependent RNA helicase DDX60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052431">
        <property type="entry name" value="SKI2_subfamily_helicases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059032">
        <property type="entry name" value="WHD_DDX60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44533">
        <property type="entry name" value="DEAD/H RNA HELICASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44533:SF4">
        <property type="entry name" value="DEAD_H RNA HELICASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26076">
        <property type="entry name" value="WHD_DDX60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="766"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="1222"/>
            <end position="1393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="555"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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            <end position="1220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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            <end position="1762"/>
        </location>
    </feature>
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            <begin position="563"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
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            <end position="1210"/>
        </location>
    </feature>
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            <begin position="1211"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1735"/>
            <end position="1750"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3305043.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1790" mass="197438" checksum="1E6B9AD47D7FB581" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ0M175_9PEZI</name>
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        </submittedName>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_062862444.1"/>
    </dbReference>
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    </dbReference>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3305209.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M197</accession>
    <name>A0AAJ0M197_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fimbrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_434021</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721095.1">
        <property type="nucleotide sequence ID" value="XM_062865788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M197"/>
    <dbReference type="GeneID" id="87884617"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110009">
        <property type="term" value="P:formin-nucleated actin cable organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21300">
        <property type="entry name" value="CH_FIMB_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21303">
        <property type="entry name" value="CH_FIMB_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000042">
        <property type="entry name" value="Fimbrin, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000010">
        <property type="entry name" value="Plastin-3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000016">
        <property type="entry name" value="Probable fimbrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000027">
        <property type="entry name" value="Probable fimbrin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039959">
        <property type="entry name" value="Fimbrin/Plastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961:SF18">
        <property type="entry name" value="FI19014P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961">
        <property type="entry name" value="FIMBRIN/PLASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="7">
        <location>
            <begin position="139"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="7">
        <location>
            <begin position="288"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="7">
        <location>
            <begin position="413"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="7">
        <location>
            <begin position="538"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="95"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00073963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3305315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="649" mass="72490" checksum="09415A968CFB7565" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M1D6</accession>
    <name>A0AAJ0M1D6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">LYR motif-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_493585</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in efficient integration of the N-module into mitochondrial respiratory chain complex I.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I LYR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721196.1">
        <property type="nucleotide sequence ID" value="XM_062866954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M1D6"/>
    <dbReference type="GeneID" id="87885783"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd20262">
        <property type="entry name" value="Complex1_LYR_LYRM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045293">
        <property type="entry name" value="Complex1_LYR_LYRM2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13675">
        <property type="entry name" value="LYR MOTIF-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13675:SF0">
        <property type="entry name" value="LYR MOTIF-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="7">
        <location>
            <begin position="37"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00026235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3305416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="102" mass="11994" checksum="E0DEB3947BB91018" modified="2024-07-24" version="1">MRALAVPVWRSVRTYATGRQARPGTTLSLEHFIQRARALALYRSILRSTRQIADARTRAETRRFARDEFERHRGVTDIDHTRYLLSTGKTEWESMERYINGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M1P7</accession>
    <name>A0AAJ0M1P7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Pyridoxal phosphate-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_208253</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721526.1">
        <property type="nucleotide sequence ID" value="XM_062862641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M1P7"/>
    <dbReference type="GeneID" id="87881470"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45677:SF8">
        <property type="entry name" value="CYSTEINE SULFINIC ACID DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45677">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="356"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3305746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="545" mass="58600" checksum="45689C4B5D05C5FA" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M1U7</accession>
    <name>A0AAJ0M1U7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone chaperone</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0T15DRAFT_533381</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with histone H3 and histone H4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ASF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721558.1">
        <property type="nucleotide sequence ID" value="XM_062869363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M1U7"/>
    <dbReference type="GeneID" id="87888192"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006337">
        <property type="term" value="P:nucleosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1490:FF:000001">
        <property type="entry name" value="Histone chaperone ASF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1490">
        <property type="entry name" value="Histone chaperone ASF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006818">
        <property type="entry name" value="ASF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036747">
        <property type="entry name" value="ASF1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017282">
        <property type="entry name" value="Hist_deposition_Asf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12040">
        <property type="entry name" value="ANTI-SILENCING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12040:SF0">
        <property type="entry name" value="HISTONE CHAPERONE ASF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04729">
        <property type="entry name" value="ASF1_hist_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037759">
        <property type="entry name" value="Histone_Asf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101546">
        <property type="entry name" value="ASF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="178"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="178"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="213"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR037759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3305778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="282" mass="31073" checksum="77D0D06DE8A0042F" modified="2024-07-24" version="1">MSVVSLLGVNVLNNPAKFTDKYEFEITFECLEPLQKDLEWKLTYVGSAQSDHYDQELDSLLVGPIPVGINKFVFEADPPDTKRIPIDELLGVTVILLTCAYDGREFVRVGYYVNNEYESEELVNDPPAKPVFEKIRRNILAEKPRVTRFAIKWDSEASAPPEFPPDQPEADLVADEEEYGAEELAEEEDELVEEGAVNGGESAEKDARMDGVEGAEGEQGVEEDELSDEGSVDIEGESEDELLEEEDEMVEGEGGGEGDGMDVDEPEPAAGAVHKQGDAMVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M257</accession>
    <name>A0AAJ0M257_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_483712</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722081.1">
        <property type="nucleotide sequence ID" value="XM_062866182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M257"/>
    <dbReference type="GeneID" id="87885011"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF129">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="44"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="329"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3306301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="364" mass="40341" checksum="70E806D385158470" modified="2024-07-24" version="1">MRFPPPEVIASWPTPNYTDPATRGPALIIIESIFLAVSVACVGLRLYVRMGTMSAKVELDDWLMVAAETFAIGVTTCVLLAYDRYGWDMHVWDLSIDTMVAGRQISFAVQALFILATCLAKISILVSYLRLSPKNSRFRRMTFVGIWWVALSSVTFFIFLFAQCSPLSSYWDLLRNAHDCTAEGPPLIAHAATTICSDFLVWVLPLPSLYRAKLPLSQRLALIVLFSVGLLVVFAACIRTYWVHYVVDGTYDITWEGFNLWLWTAVEVQLGVICGCVPWLKALVKFWRSRNTVVDLTDTWSPTVGQRTRSDRGRSMTCGEAAGSIAARTDSVGKDGNESSEEFPDLESGSNTVVGDHGEVGLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M2B2</accession>
    <name>A0AAJ0M2B2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chaperonin 10-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_140482</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722220.1">
        <property type="nucleotide sequence ID" value="XM_062861871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M2B2"/>
    <dbReference type="GeneID" id="87880700"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="13"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3306440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="360" mass="37834" checksum="5711444BB1B79208" modified="2024-07-24" version="1">MAPPSEIKAVVITAPGKAEVKTVPLPALPDDYILIRTTAVALNPTDWKHIDAVPSAVDVGAVVGCDYAGIVEQVGPKVTKKFAKGDRVAGFVHGSNRLRPEGGAFAEYIIAKGDLQIKTPDNLSDVEAATLGVGVSTVAQGLYQALGLPLPGTASPSNPPPEILIYGGSTATGLLGIQFAKLSGYRVATTCSPSNFDYVKSLGADGVFDYRSPTVVDDIRAWSNDADALTLAWDCVATDDAPRICAAALSKTREGHYRSLLNLADEVTKAVNEKVDSGFTLAYTMFGEPLDKGSPMPAIPEDFEHGVKFWELARELLAAGKIKPARADVNRGGNGLDGVLVGLKELKDGKVSGAKLVYTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M2D0</accession>
    <name>A0AAJ0M2D0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_527259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722232.1">
        <property type="nucleotide sequence ID" value="XM_062868963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M2D0"/>
    <dbReference type="GeneID" id="87887792"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022124">
        <property type="entry name" value="DUF3659"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12396">
        <property type="entry name" value="DUF3659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3306452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="313" mass="34536" checksum="49F1475C01E8BD2C" modified="2024-07-24" version="1">MAAMSERRSQSPDTRDQTEQDGIVDIEQEDQKGGDNVPGQEDDAQQHDTPDRSRSPAYVAPIPKIGSIPHVSPGIEISATDRPFLPRLIGSLLVGKVVNEDGDIVDENSGQVLARTAGDLPSMVGRRISNAQGDILGDNGELLGYVADIEWGLARPPPTASPRSLFDVMGRARSSLMVDHLGNILDPSGNVVGKFLDKNNPLHRREKEEREARERMEALPKDDPEKQPPPATAAHPQQQQEQSQSAPPHGQQRPRRTEEERRQNAEAWRKENPNESPSDIFLDVKSTREGIQLTIRIPTTFNGQQSTPHISFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M2K1</accession>
    <name>A0AAJ0M2K1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_146383</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722383.1">
        <property type="nucleotide sequence ID" value="XM_062861939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M2K1"/>
    <dbReference type="GeneID" id="87880768"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3306603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="147" mass="15738" checksum="CE1E12E9AA41EECD" modified="2024-07-24" version="1">MVQASSPSSFLLPLASSMLGSRAARCLWEVNVQYGPTLSSHQRCCVALHVLRPSTSASTGRGAPGELTLCVVSWWIVTVPVVSCSGASWVNSGVCHRTISGYGRRCYTTYTCLLFMGGRSFGGVYINRLWPLDRPGQTESVSCTGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M2L8</accession>
    <name>A0AAJ0M2L8_9PEZI</name>
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        <submittedName>
            <fullName evidence="9">Fungal transcriptional regulatory-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_148681</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAK3306648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722428.1">
        <property type="nucleotide sequence ID" value="XM_062861959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M2L8"/>
    <dbReference type="GeneID" id="87880788"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF23">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="53"/>
            <end position="81"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="168"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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            <begin position="637"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="655"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="706"/>
            <end position="717"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3306648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="991" mass="108985" checksum="D641D8EBEF6EE11E" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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            <taxon>Sordariomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722668.1">
        <property type="nucleotide sequence ID" value="XM_062869043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M2U6"/>
    <dbReference type="GeneID" id="87887872"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3306888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="104" mass="9877" checksum="21CC96EE492D9DC4" modified="2024-07-24" version="1">MLTTTALHTVGGETVTVAPTGVEVGSLTMRYPFGPTTVITPTPGPGAAGASGALATSTGGVAGGGSGGGSRQDGEEEDAAGAVRPWLVGVIWAVGVAVGVGLML</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M2V3</accession>
    <name>A0AAJ0M2V3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Origin recognition complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0T15DRAFT_162022</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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            <taxon>Sordariales</taxon>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722805.1">
        <property type="nucleotide sequence ID" value="XM_062862116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M2V3"/>
    <dbReference type="GeneID" id="87880945"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15492">
        <property type="entry name" value="PHD_BRPF_JADE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001597">
        <property type="entry name" value="Origin recognition complex subunit Orc4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016527">
        <property type="entry name" value="ORC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032705">
        <property type="entry name" value="ORC4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12087">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12087:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14629">
        <property type="entry name" value="ORC4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13831">
        <property type="entry name" value="PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="12">
        <location>
            <begin position="332"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3307025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="863" mass="94037" checksum="27F122915F9FE3EF" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M310</accession>
    <name>A0AAJ0M310_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_164150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722863.1">
        <property type="nucleotide sequence ID" value="XM_062862143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M310"/>
    <dbReference type="GeneID" id="87880972"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3307083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="225" mass="24903" checksum="333342CFF5AF15ED" modified="2024-07-24" version="1">MSLGHKQEANCQSPSEAYVHSNCSRNRQGDPMFAFAPSNGSVAMTLPESCDAHTPTRRLCSRLPDPARSLGPAEAETSCAAESRLSDRSKAARDHAVAGLSKATSRRRRRRRSFTRSSLISWLLWESGLWSTDSYLPCRVHTKGRNSLRQKMPPACRVCGSEVRCWHGKNGQGWYVQYTSRSWAVVACPTISLCSASQMQPDGDAYPNMGLRPSGSRLICLLYFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M356</accession>
    <name>A0AAJ0M356_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycosyltransferase family 15 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_168071</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723013.1">
        <property type="nucleotide sequence ID" value="XM_062862188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M356"/>
    <dbReference type="GeneID" id="87881017"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000051">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Ktr4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF6">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="39"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3307233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="430" mass="50247" checksum="3B56677CCE8049CE" modified="2024-07-24" version="1">MTTGNARYVRYILVAFFMLAVFYFVSNSDVATLRTEIPGGGTKGGDAAHANQPAKGGETDGSSPEEMKDSPNKDKIKNNYDASEFPMAMTPNDPGWNDLTGVKGGPRINATFVTLARNSDVWEIAKSIRQVEDRFNRRYNYDWVFLNDKEFDDTFKKVTTSLVSGKTHYGLIPEEHWSFPEWIDKDKAEKVRQDMKEKKIIYGDSVSYRHMCRFESGFFFRQPLMMNYEYYWRVEPSIELFCDIHYDPFRYMHENNKKYSFVLSLYEYYETIPTLWDSVKKFMKNHPEHIAAGNSMAFLSDDGGETYNKCHFWSNFEIGSLSWLRSKAYIDYFESLDQDGGFFYERWGDAPVHSIAAGIMLPKEQIHFFNDIAYYHVPFTHCPTGEKLRATLKCHCNPDDNFDWKSYSCTSRYFDINNIEKPEGWEEQKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M3D5</accession>
    <name>A0AAJ0M3D5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Permease for cytosine/purines, uracil, thiamine, allantoin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_510545</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723029.1">
        <property type="nucleotide sequence ID" value="XM_062867859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M3D5"/>
    <dbReference type="GeneID" id="87886688"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF8">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G03000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="314"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="407"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="430"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="474"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="514"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3307249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="540" mass="58757" checksum="C157F62108D0212F" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M3K4</accession>
    <name>A0AAJ0M3K4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Alpha-L-arabinofuranosidase</fullName>
            <ecNumber evidence="9">3.2.1.55</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0T15DRAFT_567085</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.</text>
            <dbReference type="EC" id="3.2.1.55"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Glycan metabolism; L-arabinan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="9"/>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723463.1">
        <property type="nucleotide sequence ID" value="XM_062870714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M3K4"/>
    <dbReference type="GeneID" id="87889543"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23399">
        <property type="entry name" value="beta-trefoil_ABD_ABFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000059">
        <property type="entry name" value="Probable alpha-L-arabinofuranosidase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015289">
        <property type="entry name" value="A-L-arabinofuranosidase_B_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038964">
        <property type="entry name" value="ABFB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007934">
        <property type="entry name" value="AbfB_ABD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036195">
        <property type="entry name" value="AbfB_ABD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39447">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39447:SF2">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05270">
        <property type="entry name" value="AbfB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09206">
        <property type="entry name" value="ArabFuran-catal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110221">
        <property type="entry name" value="AbfB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042317391" description="Alpha-L-arabinofuranosidase" evidence="9">
        <location>
            <begin position="27"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-arabinofuranosidase B catalytic" evidence="11">
        <location>
            <begin position="28"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-arabinofuranosidase B arabinose-binding" evidence="10">
        <location>
            <begin position="310"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="364"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR638964-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR638964-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF09206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3307683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="462" mass="48354" checksum="CDA28360C0182D1F" modified="2024-07-24" version="1">MLPVLYFERAWVFTLGLAAAGTLVAAGPCDIYASGGTPCIAAHSTTRALYSAYSGRLYQVKRDSDGKTTDISPLLAGRVANAAAQDSFYANTTCLIAIIYNQSGRSNHLTQAPPGGFKGPKANGYDNLASAIGAPITFNGKKAYGVFISPGTGYRNDTASSTAIGDATEGIYGIMADLENGLFSGVNPKKNTGDLSISYRFTTAAIKGRPNQWAIRGANAASTSSMSTFYSGVRPSNGYNPMRKEGAIILGIAGDNSISAQGTFYEGAMTSGYPSDATENAVQADIAAAKYATTPLTSGPALTIGSSISLRVTTSGYTDRYIAHNSSNGIVTEAVSSSSSTTLKQQATWIVRSALNGSGGNSGCVSLESRDVAGRYMRHYNFVLQLAADDGTKQMRKDATFCPQAPLNGQGNHSIRAWNYPTRYLRHYANVAYMASNGGVHAFDAAASFTEDVSFAVGAGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M3N8</accession>
    <name>A0AAJ0M3N8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein-tyrosine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_482782</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the low molecular weight phosphotyrosine protein phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3307876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723656.1">
        <property type="nucleotide sequence ID" value="XM_062866124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M3N8"/>
    <dbReference type="GeneID" id="87884953"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004726">
        <property type="term" value="F:non-membrane spanning protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16343">
        <property type="entry name" value="LMWPTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000105">
        <property type="entry name" value="Low molecular weight phosphotyrosine protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050438">
        <property type="entry name" value="LMW_PTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002115">
        <property type="entry name" value="Tyr_Pase_low_mol_wt_mml"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017867">
        <property type="entry name" value="Tyr_phospatase_low_mol_wt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11717:SF7">
        <property type="entry name" value="LOW MOLECULAR WEIGHT PHOSPHOTYROSINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11717">
        <property type="entry name" value="LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00719">
        <property type="entry name" value="LMWPTPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00720">
        <property type="entry name" value="MAMMALPTPASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="Phosphotyrosine protein phosphatases I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphotyrosine protein phosphatase I" evidence="9">
        <location>
            <begin position="5"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR617867-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3307876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="167" mass="18928" checksum="0EB4F8FB8D0FFDD9" modified="2024-07-24" version="1">MPDQISVLFVCLGNICRSTMAEGVFQSLARKPPYEDLVGKIDSCGTGGYHIGEGPDERTMSTLEDHGITDYVHYARKVDASDFDKFDYIFAMDRGNLEDLQRIQRRKRNSKAKLMLFGEYSGTGKTEVISDPYYGGRQGFEKAYEQATRFSINFLKEVFPDVEPPNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ0M3Y1_9PEZI</name>
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            <fullName evidence="4">Ricin B lectin</fullName>
        </recommendedName>
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        <name evidence="2" type="ORF">B0T15DRAFT_565311</name>
    </gene>
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        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062870668.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87889497"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042495716" description="Ricin B lectin" evidence="1">
        <location>
            <begin position="20"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3307864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="165" mass="17807" checksum="5B52144EC9CBC1EE" modified="2024-07-24" version="1">MRLDILTLLCAYGAALSSATITFRVQKASNPTSDQADAYARIEAAMSKAVARYNRLAPRASKSLTVQYVPSVATADGNFNGNIRFGSNRAYMTERTALHETAHTLGIGQTQAFNDRSWDGASAKINCGGGHIWPYGLNYENEMSETNAERHCLLINAMLADGLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M4C2</accession>
    <name>A0AAJ0M4C2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Anaphase promoting complex subunit 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_112144</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_062861514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M4C2"/>
    <dbReference type="GeneID" id="87880343"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="APC8"/>
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        <property type="entry name" value="TPR-like_helical_dom_sf"/>
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        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF10">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04049">
        <property type="entry name" value="ANAPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
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        <location>
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            <end position="314"/>
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    </feature>
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    <feature type="compositionally biased region" description="Gly residues" evidence="8">
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    </feature>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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            <dbReference type="Pfam" id="PF04049"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M4H7</accession>
    <name>A0AAJ0M4H7_9PEZI</name>
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            <fullName evidence="1">alkaline phosphatase</fullName>
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    </protein>
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    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
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                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
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                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="3">Binds 1 Mg(2+) ion.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the alkaline phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.1" evidence="1"/>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724513.1">
        <property type="nucleotide sequence ID" value="XM_062866154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M4H7"/>
    <dbReference type="GeneID" id="87884983"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16012">
        <property type="entry name" value="ALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001952">
        <property type="entry name" value="Alkaline_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596:SF72">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00245">
        <property type="entry name" value="Alk_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00113">
        <property type="entry name" value="ALKPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00098">
        <property type="entry name" value="alkPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042611469" description="alkaline phosphatase" evidence="5">
        <location>
            <begin position="22"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="2">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="489"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="490"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="612"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3308733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="662" mass="71838" checksum="EFCDED4B92594C10" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M4L9</accession>
    <name>A0AAJ0M4L9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_524931</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724439.1">
        <property type="nucleotide sequence ID" value="XM_062868807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M4L9"/>
    <dbReference type="GeneID" id="87887636"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="11"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="49"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3308659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="232" mass="25235" checksum="E6E65CA2FFA6E684" modified="2024-07-24" version="1">MSQPLKRTFHGCLTCRRRKVRCLGGNPCLNCSRMSVTCHSSFDTNLRIRISTPTGQKDLEAKPPAQKSRKAQKPASPAAPAPVIVTDSSVPLATSWPSPDGPFPHHAAVFDPEQSNFDTLAAPLASAQEASYLNPLQHPAIWDVGTSPLDSQPFEHAFNPYLESQPATPFICPPLSLDSSTMWAPDFQHTSSPFAWNAASWNSLEQEELGRDCRLAGTQPPQGAGYRGSKGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M4T7</accession>
    <name>A0AAJ0M4T7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">COP9 signalosome complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_390502</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3309092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724872.1">
        <property type="nucleotide sequence ID" value="XM_062864540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M4T7"/>
    <dbReference type="GeneID" id="87883369"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055089">
        <property type="entry name" value="COP9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050756">
        <property type="entry name" value="CSN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758:SF1">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22788">
        <property type="entry name" value="COP9_hel_rpt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="8">
        <location>
            <begin position="229"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3309092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="485" mass="53673" checksum="B02279D955E00AB9" modified="2024-07-24" version="1">MDQAVAVLLNFPPPGGFADDAQYHSAAQSHVLEVEKLTAKADFNKSYAAQLLDHVNPALNSISYLSLLLAVRGANSLPQADLLAKFSVFLCTFDARQIRYRSSAFSVVLDLLASGSLFPASVAVDLLTTALLRLDPTGSVLTPHHVALVKLAYTTDAVEPALPLLEKDIIFYPGVKGLLETRPLSDPDLPPAAYMNREPGVQKSLSHSDILEYDLLRALCFIQRRAWRQAFDALERVLTYPARDSHSCSKIMVEAHNKWILVGLLLNGKVPTMPATMAAGAQKSLAALGKPYQSIGKAFEENTAESLKAEYESLGAQFFSQENNLNLMRLVMQHYQRWQILNLRQVYTKISLEQIRARTQSAETAAPLATEAEIEKLVQEMIDEGMLSGVIERPDGGLAHLIFVSPNEELSEAEFAQKMMRTAQRLKELEPLVKAASERLGTSRDYIKYLAGQQKKEKDGWRDYDASFVNTVEDEDLMTGVVAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M4Z9</accession>
    <name>A0AAJ0M4Z9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_526750</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3309272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725052.1">
        <property type="nucleotide sequence ID" value="XM_062868924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M4Z9"/>
    <dbReference type="GeneID" id="87887753"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051698">
        <property type="term" value="F:saccharopine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF26">
        <property type="entry name" value="L-SACCHAROPINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="13"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3309272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="430" mass="46093" checksum="34348BD3FCC4C2A4" modified="2024-07-24" version="1">MTDTGKMTPDSSILIAGAGTFGLSTAYHLAKAGYKNITVLEKSPTIPSPLSAGNDLNKILRAEYEDPFYTNLALQAMREWKHNPVFAPYYHETGYLLCTSAAAPEKSKRSLAKSLSSISSHPAWQGGVIHPVNERDDIRTLAPALDGPMHGWTGYLNKLAGYAHAADALRATHAACRALGVTFHLGDGVMELLYKDHTNNVCIGARAASGAVHTADVVVLALGAALGTVLGLVGRQITARAWSVGHVQLSEEEAGRLKGIPVTYARDLGFFFEPDEKTRLLKVCPAGAGYTNFVKNDSEASPVSVPPEDSGWIPASDEATIRKLLGETLPALADRPIVDKKLCWCADTADTEYIIDFVPGKTGVMVVSGDSGHAYKMLPVVGSWVKDVLEGGSQDIPRWRWKAGQDAGGDVSWRVGESVDIKDVQDKVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M512</accession>
    <name>A0AAJ0M512_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_136081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3309288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725068.1">
        <property type="nucleotide sequence ID" value="XM_062861812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M512"/>
    <dbReference type="GeneID" id="87880641"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3309288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="148" mass="16720" checksum="1397F25CEB67D662" modified="2024-07-24" version="1">MQLRPAANEPESQPNYSPETAQRPRRTDFLHPGYSNGIVLLSLPALDSGGIDYDTALTACGLIAGNRWGDGFFSSDRIGALRVERPNGGILREAQYFFQLPAPLDPPYPVVPRFAEWRFPHTICHPCSRDGRKMRQRPARQQRQRGYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M561</accession>
    <name>A0AAJ0M561_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_135694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3309259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725039.1">
        <property type="nucleotide sequence ID" value="XM_062861804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M561"/>
    <dbReference type="GeneID" id="87880633"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="466"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3309259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="556" mass="61232" checksum="FAFB39732935CAEC" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M5C7</accession>
    <name>A0AAJ0M5C7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_389181</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725172.1">
        <property type="nucleotide sequence ID" value="XM_062864474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M5C7"/>
    <dbReference type="GeneID" id="87883303"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3309392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="207" mass="22395" checksum="C938E26629D02C85" modified="2024-07-24" version="1" fragment="single">LLPETARSILGDGSAAVNPINKAPIPILSPKASQEGGGRPDAVPREDHRKFPNPLAALRLLRIPGTAIILVAYDINYTVYCCLQASLATLFVDTYQVSGLTARLIYLPFGVAVALSAFATGRLLDVNYSKTAAELGISVKIDEGTKLKDFPIYSARCLQLYPLRSGAACLEALDTILRRLGPGWSFLLFGVLLVLLFLCYFCCSSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M5J1</accession>
    <name>A0AAJ0M5J1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">xylan 1,4-beta-xylosidase</fullName>
            <ecNumber evidence="11">3.2.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0T15DRAFT_17150</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Hydrolysis of (1-&gt;4)-beta-D-xylans, to remove successive D-xylose residues from the non-reducing termini.</text>
            <dbReference type="EC" id="3.2.1.37"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.37" evidence="11"/>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725668.1">
        <property type="nucleotide sequence ID" value="XM_062862200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M5J1"/>
    <dbReference type="GeneID" id="87881029"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009044">
        <property type="term" value="F:xylan 1,4-beta-xylosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="P:xylan catabolic process"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
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        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
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        <property type="entry name" value="Immunoglobulins"/>
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    </dbReference>
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        <property type="entry name" value="BXL"/>
    </dbReference>
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        <property type="entry name" value="Fn3-like"/>
    </dbReference>
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        <property type="entry name" value="GH"/>
    </dbReference>
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        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
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        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721:SF3">
        <property type="entry name" value="BETA-D-XYLOSIDASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721">
        <property type="entry name" value="SUGAR HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042462320" description="xylan 1,4-beta-xylosidase" evidence="12">
        <location>
            <begin position="23"/>
            <end position="840"/>
        </location>
    </feature>
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        <location>
            <begin position="705"/>
            <end position="775"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00024574"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00026107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3309888.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="840" mass="91039" checksum="4EEB80E4A10F6C61" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ0M5N4_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">DnaJ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_12754</name>
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    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Chaetomiaceae</taxon>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062861707.1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24074">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DJLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
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        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="10"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3309722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="263" mass="27794" checksum="CD3F7EA129221BFF" modified="2024-07-24" version="1">MASKTGRPPNYYAILEISETASTSQIRDAYKRAALKTHPDRVPADHPERAQRTRKFQLVNDAYYTLSDRTRRREYDAQRKLYAGSGGSRTGGSSMPGGFGGAFTDPFADADYTSTAGAGGVPGAGAAPGGGMGAGGMPFSWAWNFFTGGQQPQEERERTENEQFADVFEEMLREEGLAEEGPGARPTGKFWSVLGGISGGALGFIVANVPGLVAGAVAGNRLGAVRDAKGKSVYAVFQELPQGDRARLLSQLAARVLSHAVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M5Z4</accession>
    <name>A0AAJ0M5Z4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_25805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725910.1">
        <property type="nucleotide sequence ID" value="XM_062863277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M5Z4"/>
    <dbReference type="GeneID" id="87882106"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11578">
        <property type="entry name" value="DUF3237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3310130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="164" mass="17439" checksum="F32BBDA0FA4E2AA6" modified="2024-07-24" version="1">MADFPKLIPAFTVQVAIDPPKPISSTLTVVPFRSEGGSIVSEPSYPIQLNAAITHGADYIKAFPDGRHVRLDVQSTARDGATGALVRFIYTGKISTLGAAGKVLRGEADAATTPFGDAFSVVEFETGDEKLTALHEKIYVGSGRFILEQGKPVIVEYKVSEVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M665</accession>
    <name>A0AAJ0M665_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-loop-helix DNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_518319</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3310369.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="1">DUF7779 domain-containing protein</fullName>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726883.1">
        <property type="nucleotide sequence ID" value="XM_062871129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M6P9"/>
    <dbReference type="GeneID" id="87889958"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056681">
        <property type="entry name" value="DUF7779"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25000">
        <property type="entry name" value="DUF7779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7779" evidence="1">
        <location>
            <begin position="187"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3311103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="364" mass="41609" checksum="AD8B1488D346C377" modified="2024-07-24" version="1">MTRIRGMSRLDFILAHGFPDNSPENKARRKNLVQDVARFFALAWKAPQKVDQAYRDRMAEGPRGSVLTTPRDFRLIAQKGGIELSVLDEESAVTLLTSMSRFNGDKLDDDERKEELDAALSIVRRIDCLPLAIMHSANLVLSDSCTFSEFLEAYSNRELIQDCEEVRLVNQSSGAAYRYSLRTVWNMSFDRLDSGAQSLIRMLSYMDPDRVQLRHLADGVGKAKDPALGFMDIAYKRNKLKVQLLRSSLVTQSKKHKELRVHRLVQASCHLRMDLEERRQSFKNALTIVKHCWPVPPRTAIYDPALWDAQQALLPHVQSLCAHYVVSCKEGNPLIPPETVNWDFPMILYEAGWYCYERALHALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M6X4</accession>
    <name>A0AAJ0M6X4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MGS207 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_482266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726944.1">
        <property type="nucleotide sequence ID" value="XM_062866088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M6X4"/>
    <dbReference type="GeneID" id="87884917"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025337">
        <property type="entry name" value="Questin_oxidase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870:SF6">
        <property type="entry name" value="MGS207 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14027">
        <property type="entry name" value="Questin_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3311164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="453" mass="51874" checksum="1C45A1E6CF1CAB03" modified="2024-07-24" version="1">MTVKRGQSYLGNHHVAVKGAPAVTLCRSLNVLPDLGDDRRPEGEVWDEVAVPGGGEEAVDEPKSIDLEPVEVHNVEANPDKRPRTLKHLLRANHVNHSIIYHNLQFDNHMPHILCSAYHLGAESHQLYHIYDEEAKELEPWKESPSEVAQDDWREFLGDKRYQRAYVDFFEDALAMKYAYNWKRVIEEYLLKGEEPLVNGLIGGLGHPLIHLGYAYEFDSREVAIEALALAATQYNFLHQYIDDPSYTRKPSFSSTSPLELINKLASDDRFDGLFKEPGFANIEPLFQKHESLILEYWNAWDLQSSDDPVRLFRESQEAAVALLVATVRPGTHAYNFFIVHVLTTSHAVRILLPLLPAKFHVSLVRQWWLLALAVYIAELRPKTDPDYVPADLKGKGWKHVEYQALNSEWATDAHYVKAIRAMKEAARTWGDVHDRYLAAAVRFVDDFEGWVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M724</accession>
    <name>A0AAJ0M724_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nop domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_482374</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PRP31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727109.1">
        <property type="nucleotide sequence ID" value="XM_062866098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M724"/>
    <dbReference type="GeneID" id="87884927"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000002">
        <property type="entry name" value="U4/U6 small nuclear ribonucleoprotein Prp31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.4070:FF:000003">
        <property type="entry name" value="U4/U6 small nuclear ribonucleoprotein PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027105">
        <property type="entry name" value="Prp31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019175">
        <property type="entry name" value="Prp31_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13904">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13904:SF0">
        <property type="entry name" value="U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09785">
        <property type="entry name" value="Prp31_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Nop" evidence="10">
        <location>
            <begin position="274"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="394"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="574"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="410"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="586"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3311329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="605" mass="64360" checksum="013EADF4C1CA6A6B" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M752</accession>
    <name>A0AAJ0M752_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_79365</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727318.1">
        <property type="nucleotide sequence ID" value="XM_062871323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M752"/>
    <dbReference type="GeneID" id="87890152"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF295">
        <property type="entry name" value="ACETYL-COA SYNTHETASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="47"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="3">
        <location>
            <begin position="542"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3311538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="657" mass="69881" checksum="255B665CA3523743" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M785</accession>
    <name>A0AAJ0M785_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_522099</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727408.1">
        <property type="nucleotide sequence ID" value="XM_062868603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M785"/>
    <dbReference type="GeneID" id="87887432"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF30">
        <property type="entry name" value="MID2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042572350" description="Mid2 domain-containing protein" evidence="7">
        <location>
            <begin position="24"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="157"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="157"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="209"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="263"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3311628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="35603" checksum="AB2228CE6825BC69" modified="2024-07-24" version="1">MKAFNPLSPTFFTLFTHLLLCQAICYYPSGDVAPQDLPCNDEAGQAACCGPAYVCLSNGICMSSGLEKQLPNQALYVRGSCTDKDWRSSKCPSFCVDPAKGHKLDGGIGIKKCPNRSDDTYHCDDGQPFDCDLLDNVLSFQGTPTVMTTIGVARSTTQLSTTTTTTTTSSLSSATTTLSSSTTPSPTPNSKPTSDPSNSVTANVAPAESSSSPGSSPQPSDSQPSNGLIIGLAVAVPSGVLGLAAAGLTFFWSRRKLKRAANARTQGTTTTNNSGMEQAPAKMDGPPVPGYINGYNMYHHHYKPPEPGLAVAEAWVPPTELPGGTGVNPVAWELPGGNRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M787</accession>
    <name>A0AAJ0M787_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0T15DRAFT_385695</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_062864292.1"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="SET2_Histone-Lys_MeTrsfase"/>
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        <property type="entry name" value="SET_dom"/>
    </dbReference>
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        <property type="entry name" value="SET_dom_sf"/>
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        <property type="entry name" value="SET DOMAIN PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PostSET"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AWS" evidence="11">
        <location>
            <begin position="447"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="9">
        <location>
            <begin position="505"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="10">
        <location>
            <begin position="629"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="136"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="170"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="295"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="645"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="734"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="800"/>
            <end position="885"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="20"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="176"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
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    </feature>
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        <location>
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    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50868"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51215"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3311480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="901" mass="96819" checksum="F4EB309729ABFD77" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GKL6</accession>
    <name>A0AAJ0GKL6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mitochondrial distribution and morphology protein 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Mitochondrial inheritance component MDM10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MDM10</name>
        <name evidence="8" type="ORF">B0T15DRAFT_319390</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. MDM10 is involved in the late assembly steps of the general translocase of the mitochondrial outer membrane (TOM complex). Functions in the TOM40-specific route of the assembly of outer membrane beta-barrel proteins, including the association of TOM40 with the receptor TOM22 and small TOM proteins. Can associate with the SAM(core) complex as well as the MDM12-MMM1 complex, both involved in late steps of the major beta-barrel assembly pathway, that is responsible for biogenesis of all outer membrane beta-barrel proteins. May act as a switch that shuttles between both complexes and channels precursor proteins into the TOM40-specific pathway. Plays a role in mitochondrial morphology and in the inheritance of mitochondria.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34. Associates with the mitochondrial outer membrane sorting assembly machinery SAM(core) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion outer membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="6">The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.</text>
    </comment>
    <comment type="domain">
        <text evidence="6">Lacks alpha-helical transmembrane segments, suggesting that it resides in the membrane via beta-sheet conformations similar to those predicted for other outer membrane proteins and porin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MDM10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAK3301635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001401">
        <property type="term" value="C:SAM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051654">
        <property type="term" value="P:establishment of mitochondrion localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070096">
        <property type="term" value="P:mitochondrial outer membrane translocase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03102">
        <property type="entry name" value="Mdm10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027539">
        <property type="entry name" value="Mdm10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28035">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28035:SF1">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12519">
        <property type="entry name" value="MDM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1 6" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="344"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="358"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="382"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3301635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="452" mass="49643" checksum="DD965A6A1CD779E6" modified="2024-07-24" version="1">MREFMYYITHAFYSATGWNEDNTYKELNATARELIDFPLPRGLRLTLSSLATPHFATSYQLGSVGIVDGSISYLHSTLPLTGIAAQSDRIPLPALLRSYRQLHDLGSGDRRQWYWGTEEPPAETAAISSTDGIPDRHGSSLFYGRLYLPRSLLEGLVIRRLTPDLQVQLSAVSERSLRNGGTLLGLAQYDRGKYGVEGLASTDGGLLGIRGLYNFGGDTSSTAATLPTNSSSSENNGGGQLGERERIYGRFSAGGEVYYGTLNKSGGMSLGARFATLPAHRGTPLTATLTINPLMGNINATYAVLARDYCSLATRMEFNVYSYESEWAVGMELWSNRRPAGFLLGADPNSQSDPDPGPPRRKERSFQAKLEWRLDDEESESEAPRREAKPAAARSGKEYRGVLKARLDQNLRIGLLWEGRVKSLIFSLGTGVDLRKLGEPFRSLGLEVQYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GKM8</accession>
    <name>A0AAJ0GKM8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_405376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717428.1">
        <property type="nucleotide sequence ID" value="XM_062865293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GKM8"/>
    <dbReference type="GeneID" id="87884122"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3301648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="255" mass="29183" checksum="63F8F9316A3A8294" modified="2024-07-24" version="1">MYRQPCLTTRATPYWIEPQCHHLTMAAIYHDTLRCMRCERQPPEGFLYRCTVDREPLILSAKAKGDRVTFDSLGDAFAEEMTLGRFGPDARRKQHSFLNEITPEEITSYTLEQLSTILEQRKNVIDDQRRECYRTGKIYPDDTMPWVRQETHECQHVVCHQCYPRGREKSWVSLNGVLNGDILPTVATGFSFSYSGSRPCADANVVRNIGCRAVPLVRITHTDPFPLRPALLTLSSHGSTRRGLPHRRIQGPPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GL23</accession>
    <name>A0AAJ0GL23_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_325624</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717653.1">
        <property type="nucleotide sequence ID" value="XM_062864111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GL23"/>
    <dbReference type="GeneID" id="87882940"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF4">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3301873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="502" mass="54493" checksum="2AFC9B8A7ED1E4AF" modified="2024-07-24" version="1">MSRSDAAPLPPKTHASSGNDAAAAGQLGQAPYDAGTGEVINMDEYRRTVPWWKRAYKHSLTQMMLLSVQAFCGPAMWDAIAGLGGGGLATPQTSNISNAINYAALALVCLIGGPLVNKIGIKWALVIGAVTFPIQGSAYYCNSAFGNQWYLIFAGFVSGIGTGCWYVAEAGAIMSLAPSGARGKYLALWIVSRNLGQLVGGAINLAKNHEKGVDGGVTPDTYIVFIVIQCLALPFAFLLSPLEKVVRSDGTRILVSEKLRSRDEFKLIKSTLTSRLILLSAFWALWSFFYSGTWSTYLATYFSTRARALSSLISPFFCIIGCFGLGFILDLKGVSQRRRAQLGLWTVVILNAGVYVWSIVMQVGFNRHNPGHIDWDEPLYAKSFLPYFFVQTTGPLSQSYMYWLLSSFATDAQANVRNGAAFRCLEAVGQAISYGMNTQIEASPLIGFIVSFALMAVALGPMLLLVRSTPERIPADVVVEEQEKALQGKLDGFRAEERQSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GLX8</accession>
    <name>A0AAJ0GLX8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Armadillo-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_301846</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphatase 2A regulatory subunit A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718120.1">
        <property type="nucleotide sequence ID" value="XM_062863820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GLX8"/>
    <dbReference type="GeneID" id="87882649"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000011">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A regulatory subunit A alpha isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055231">
        <property type="entry name" value="2AA_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054573">
        <property type="entry name" value="PP2A/SF3B1-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051023">
        <property type="entry name" value="PP2A_Regulatory_Subunit_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648:SF4">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2 (FORMERLY 2A), REGULATORY SUBUNIT A, BETA ISOFORM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A 65 KDA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22646">
        <property type="entry name" value="PPP2R1A-like_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22956">
        <property type="entry name" value="VPS15-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="91"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="207"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="248"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatase PP2A regulatory subunit A/Splicing factor 3B subunit 1-like HEAT repeat" evidence="4">
        <location>
            <begin position="281"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="287"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="326"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="365"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatase 2A Regulatory Subunit A helical" evidence="5">
        <location>
            <begin position="368"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="404"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="521"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3302340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="625" mass="69205" checksum="10CD7148BC2BFE07" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GME6</accession>
    <name>A0AAJ0GME6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nickel/cobalt efflux system</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_311582</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the NiCoT transporter (TC 2.A.52) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718416.1">
        <property type="nucleotide sequence ID" value="XM_062863933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GME6"/>
    <dbReference type="GeneID" id="87882762"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015099">
        <property type="term" value="F:nickel cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004688">
        <property type="entry name" value="Ni/Co_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011541">
        <property type="entry name" value="Ni/Co_transpt_high_affinity"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31611">
        <property type="entry name" value="HIGH-AFFINITY NICKEL TRANSPORT PROTEIN NIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31611:SF0">
        <property type="entry name" value="HIGH-AFFINITY NICKEL TRANSPORT PROTEIN NIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03824">
        <property type="entry name" value="NicO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0533">Nickel</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="209"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="279"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="366"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3302636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="397" mass="42770" checksum="418256C0C59D3447" modified="2024-07-24" version="1">MRLPGPLSAIPPRALQLIALLVLVNAIVWAVAGVVLHFHPTLISPAVLSYTLGLRHALDADHISAIDLTTRRLIASGQRPVAVGTFFSLGHSCVVIITCVVVAATAGALRERFADFQRVGGIIGTSVSAAFLLLLCVGNGWVLWRLVRRLRVVLAEQRRGETDQSVYDDDDDTTGTGQRGVQQQLEGAGLMGRAFRVVFKIVDRPWKMLPLGFLFGLGFDTSSEVALLGIASIQATNGTNIWVILIFPALFTAGMCLLDTTDGALMMALYTSKAFSRDVVAILYYSIVLTGITVFVSAFIGVIQVLSLVQNVADPEGGFWDGVSEIGEYYDVIGGCICGLFLLVGLGSVLVYRPWRRRMERRAASRAAEGQITPEPQSPDALLPPDMPRAPGYGTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GMI6</accession>
    <name>A0AAJ0GMI6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_367912</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718489.1">
        <property type="nucleotide sequence ID" value="XM_062864180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GMI6"/>
    <dbReference type="GeneID" id="87883009"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3302709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="99" mass="10648" checksum="7D4598B98526E533" modified="2024-07-24" version="1" fragment="single">GMTPFAYACRSSGIGVVELILDSYLLRDGLVNPDSTDNDGMTPLAHACKRGSIGVVKLIFDSYLLRGGLVNPNARDKSGLTPLAHACRWGRGEIIELFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GMJ7</accession>
    <name>A0AAJ0GMJ7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_562708</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718494.1">
        <property type="nucleotide sequence ID" value="XM_062870589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GMJ7"/>
    <dbReference type="GeneID" id="87889418"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3302714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="249" mass="28275" checksum="27B1812681539CCD" modified="2024-07-24" version="1">MQWTAVKVASQILRHHHGVTACVIGDLALTYYNAPGKHNVSELELCVPDSSVNAAPGLLCSTGLFEPADLRKESAVDIQLHMRLCMSKYRLHFPSLRTTGWTEPLVLILLPASFFGLGRIEDLLVKWPEGRSFHLSKYLLAEGLGQNDIERISFPRLKPLITWLGKSYLYTNDGYERHPLQDLVDGLNLDEVWIQNHLQDANPALAALLKGFIRTKRERIYMYGSDNTVTRFIKDEKEAEDVKRIPGYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GML8</accession>
    <name>A0AAJ0GML8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aspartic peptidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_314507</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718548.1">
        <property type="nucleotide sequence ID" value="XM_062863968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GML8"/>
    <dbReference type="GeneID" id="87882797"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF73">
        <property type="entry name" value="PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042564657" evidence="4">
        <location>
            <begin position="23"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="512"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="5">
        <location>
            <begin position="59"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="544"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="558"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="616"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="690"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3302768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="701" mass="74054" checksum="45610DB0DD268A77" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GMR6</accession>
    <name>A0AAJ0GMR6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_543297</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
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            <taxon>Sordariomycetidae</taxon>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
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                <person name="Natvig D.O."/>
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                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
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                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
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                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="1">CBS 333.67</strain>
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        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
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                <person name="Martin F."/>
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                <person name="Natvig D."/>
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                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
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                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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    </evidence>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
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                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
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                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
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                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
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                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <source>
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<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062869708.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87888537"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
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</entry>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="EMBL" id="JAUDZG010000006">
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062870507.1"/>
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    <dbReference type="AlphaFoldDB" id="A0AAJ0GNC9"/>
    <dbReference type="GeneID" id="87889336"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="PANTHER" id="PTHR40788:SF2">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR40788">
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    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3302910.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="721" mass="83226" checksum="C87FE9E68F3BEA3E" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ0GNF1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_576585</name>
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    <organism evidence="2 3">
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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            <dbReference type="PubMed" id="37820761"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718957.1">
        <property type="nucleotide sequence ID" value="XM_062871037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GNF1"/>
    <dbReference type="GeneID" id="87889866"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="488" mass="53629" checksum="A2CF2C3E8ACB0261" modified="2024-07-24" version="1">MASESASLEQNKPSRSSCKLVPPCRSVQHGISIDSAGQTKTKPIGKYYFTEDALKYDLAALKKGEVYSREEFYRRAKTWYKAEIDRLLHLKRIEKEDKPEVTLTTQYPTEQREEDSRLIPAQAKGDRISSPAAAPSPTPSPAKAPTRVQPARAAKRKAAERLFTRSSRAPSRRTKGKLAKPHVSDPPPSKETRHPEPEAEPETKGNYALAAYDWAQFLSGNEEEHGRSPWSYIQFQGLDVAYFVMRLERAVRRKTCEIRLGRTGEPGLWSCCAARGATSKADDEEERRKERPKQQQKADCQRRIRNPPPGTKSRCVLDGPRYTAPVAPFTPKAALAPGEDWRSPTVTTTTITSPAKAGDDRKTKTANGGPASTTETTPAASGSKPGIISWAADEVRRRDELNKRAAAAAAAVAAGLAPEAEMEVSPTLGRWQVRARKLEGEELHPVEDLEANNVVEVSSLKFAVDLCACPSEGGAMEAGEEGLRVLMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GNT3</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719168.1">
        <property type="nucleotide sequence ID" value="XM_062864248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GNT3"/>
    <dbReference type="GeneID" id="87883077"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="551"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="462"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="578"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3303388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="608" mass="65281" checksum="E75F5B3F5C4B98C6" modified="2024-07-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GNX2</accession>
    <name>A0AAJ0GNX2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pre-rRNA-processing protein TSR2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_276711</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TSR2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719268.1">
        <property type="nucleotide sequence ID" value="XM_062863528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GNX2"/>
    <dbReference type="GeneID" id="87882357"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019398">
        <property type="entry name" value="Pre-rRNA_process_TSR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21250">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN TSR2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10273">
        <property type="entry name" value="WGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="72"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="165"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="175"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3303488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="232" mass="25844" checksum="37911EFC985BF11F" modified="2024-07-24" version="1">MSSNASPSPATCQETFEQGVALALHLWPALTLAVQNNWGGPDSSDKRDWFAGVIVELFPDVSKLTPSQLQQRIQWQQHKLPPPPPPQQQQQTLAQNGAGSGANEEPDQEDVEERLLQVMLDEFEVNVDDESAWDIAGQVVQLRAECLRGKFEGVEALRKRWEGRKGSKVVIAQAEDQDGETDWDTDDDEEGGEEGDVEMDEAPALAEAPARKQREEPEVDEDGFTKVTRKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GP45</accession>
    <name>A0AAJ0GP45_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidase signature domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_486960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719373.1">
        <property type="nucleotide sequence ID" value="XM_062866399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GP45"/>
    <dbReference type="GeneID" id="87885228"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF67">
        <property type="entry name" value="AMIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="128"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3303593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="582" mass="63564" checksum="24CC908E94A8F57D" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GPG2</accession>
    <name>A0AAJ0GPG2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_439433</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719466.1">
        <property type="nucleotide sequence ID" value="XM_062865890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GPG2"/>
    <dbReference type="GeneID" id="87884719"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF31">
        <property type="entry name" value="STERYL ACETYL HYDROLASE MUG81-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="155"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="289"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3303686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="422" mass="45349" checksum="8B527ECE69E26775" modified="2024-07-24" version="1">MTRSFRLRHSRGEPPAAEHDEHDEAPPFGALSWLSLLSRATCITGHLAFKAITALPPSRRAGLSFHEYVAYEGMRDYQCGLDAVGIQHLLAPTTTTCRRYARRHKIPYSEIRLPDGTVAAWLGPRNHRHPSSSPPSSSSSSSSSSSKGGGVRVRVLFHGGGYMSPALPDHLDMAFGFPAGQTPEAGVAVVVLEYALASERRNHYPAQLAQAACLLEHLLRVEKVPPARVTLLGDSAGGHLLLGLLLHVRHPNPDPAVPAVAVEEDGRFAGAALVSPWVELGKPSFSLSSASGMGESSSSGGGGGGGGKRDIVTPESLAYWARNLLGGAEADPWNSPLLAPREWWADLPVDEVLVTYGGAELFRDDVARLGEILRSEHPRTTTVAACEGEIHVHMVMNRFLKIRKPCQSEEVFVRWLAGRSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GPV1</accession>
    <name>A0AAJ0GPV1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hypervirulence associated protein TUDOR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_398935</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3303943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719723.1">
        <property type="nucleotide sequence ID" value="XM_062864981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GPV1"/>
    <dbReference type="GeneID" id="87883810"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021331">
        <property type="entry name" value="Hva1_TUDOR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11160">
        <property type="entry name" value="Hva1_TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hypervirulence associated protein TUDOR" evidence="2">
        <location>
            <begin position="5"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3303943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="73" mass="8077" checksum="E2B218BEF24F586A" modified="2024-07-24" version="1">MYKVGQTVRYKPVGGPGSNTSESTGVIKNVLTEPGRQAERNVQASQDRPRYEIENSNTGKMTSVYEDNILEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQI6</accession>
    <name>A0AAJ0GQI6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Shugoshin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0T15DRAFT_485965</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the shugoshin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720062.1">
        <property type="nucleotide sequence ID" value="XM_062866326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQI6"/>
    <dbReference type="GeneID" id="87885155"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000779">
        <property type="term" value="C:condensed chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720503.1">
        <property type="nucleotide sequence ID" value="XM_062863188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GRC4"/>
    <dbReference type="GeneID" id="87882017"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3304723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="225" mass="24544" checksum="E4FFD29043F95C37" modified="2024-07-24" version="1">MTMTDEELDRDWQPNGRRPQSTIAQMFSQELMDIFRIENSVTDLDEQVDKRKQQIDAQTSELEALEARIREMERRLKMQTNPDNPGGSGAQSGTPGGQSQAPPEKGYSAADLSRAWEQRDHLQQQIKNASRPGTAQQNQPAVRGGLPPTPAGSEGEFESPVSHPSQLVLRPRRARAQPDPGAAVPSSSPLKEGGDSDSIKAMSESASCADYVIVPKPDGDRERGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GRC7</accession>
    <name>A0AAJ0GRC7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_558658</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720466.1">
        <property type="nucleotide sequence ID" value="XM_062870478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GRC7"/>
    <dbReference type="GeneID" id="87889307"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="49"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3304686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="695" mass="79088" checksum="E9A40348370CC6A5" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GRG2</accession>
    <name>A0AAJ0GRG2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_400344</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720310.1">
        <property type="nucleotide sequence ID" value="XM_062865054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GRG2"/>
    <dbReference type="GeneID" id="87883883"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005371">
        <property type="term" value="F:tricarboxylate secondary active transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015742">
        <property type="term" value="P:alpha-ketoglutarate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006843">
        <property type="term" value="P:mitochondrial citrate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000053">
        <property type="entry name" value="Mitochondrial DNA replication protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000085">
        <property type="entry name" value="Tricarboxylate carrier, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053017">
        <property type="entry name" value="Mito_Cit/Oxoglu_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46982">
        <property type="entry name" value="CITRATE/OXOGLUTARATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46982:SF1">
        <property type="entry name" value="CITRATE_OXOGLUTARATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="6">
        <location>
            <begin position="21"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="6">
        <location>
            <begin position="114"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="6">
        <location>
            <begin position="215"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3304530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="316" mass="33957" checksum="4852D0247ED2E102" modified="2024-07-24" version="1">MSAAVAPAPAAQPPKLEKKPIKFSNLLLGAGLNMFEVTTLGQPLEVIKTTMAAHRGDGFTTALGRIWNRGGILGFYQGLIPWAWIEASTKGAVLLFVASEAEYYARRAGANDFGSGIIGGVTGGVAQAYATMGFCTCMKTVEITKHKVAASGQKPPGTWATFMDIYRREGIRGINKGVNAVAIRQMTNWGSRFGLSRLAEQGIRKVTGKEHGEKLSAFEKIIASALGGGLSAWNQPIEVIRVEMQSKKEDPNRPKKMTVGNTFKYIYQTNGVKGLYRGVTPRIGLGVWQTVCMVAMGDMCVSLPSNGAPLLPGRRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ0GRP7_9PEZI</name>
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        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_400636</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720666.1">
        <property type="nucleotide sequence ID" value="XM_062865073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GRP7"/>
    <dbReference type="GeneID" id="87883902"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042460168" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3304886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="335" mass="34857" checksum="B03B4B7AFD2F874E" modified="2024-07-24" version="1">MRAFGHIILLLTFFHVCVAKNKCYYPNGVQSDSDFPCDPNAEQSPCCGGSFGSVCLTNKLCRGPDGNLIRGSCTAQDWSAPECAHYCLGATRGGTDLISCQNVTGTDTLFCCDPGRAFCCNDGVARFEVLPSKPQILATWDMSASQFVVVLKTASPSSSLSVSTTLATTTWTQGPPASTSSGAADQSTGQTQQTTSSGSSGGLPVAAQAGIGAGVAVLAISLGIIAFLLWKLRQRNKLEKGAAAHHPAGGPRLYEPGDRTLGGEPWHYPASGSGEGVAAAGLVGVTAEMPEKEPQEMQGWDPHNPAYGYGSNLQPGGRDAVARAELPVSPRDRAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ0GS83_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ecp2 effector protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_574566</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720939.1">
        <property type="nucleotide sequence ID" value="XM_062870961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GS83"/>
    <dbReference type="GeneID" id="87889790"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35605">
        <property type="entry name" value="ECP2 EFFECTOR PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35605:SF1">
        <property type="entry name" value="ECP2 EFFECTOR PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042520161" description="Ecp2 effector protein domain-containing protein" evidence="1">
        <location>
            <begin position="28"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3305159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="212" mass="22800" checksum="84765CFAD558C971" modified="2024-07-24" version="1">MKAKSFAATFFFSMGAIAAALPDPMQGYSITAMAWEVPLFPGSDERLVFNGTVEDVHTEVLKHNRNWDADFLARCTSPAPAGAGAGAGAGAGGSVVDKRETDFGGGAYFCGARWPYANHWRVMQGVDYLSHIPGKVQLAAGPGACSRVSCSYRAAIYVCNDNNRDIELDSFIRIADGARYIAGWCVQQPGPTVAGQLFHPDNWNVIVREDDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GSE6</accession>
    <name>A0AAJ0GSE6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_192273</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">Uncharacterized protein</fullName>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
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                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    <organism evidence="3 4">
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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            <dbReference type="PubMed" id="37820761"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721507.1">
        <property type="nucleotide sequence ID" value="XM_062869354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GTB5"/>
    <dbReference type="GeneID" id="87888183"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3305727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="357" mass="40636" checksum="60E6D014B6322038" modified="2024-07-24" version="1">MPPKGKARLTPTTTKKGGIPSSPPHPFKPVPSSLQPFVATLPTQHVYITHIDPRPPAFKRNIFLVPVAMNLAVVGLFVWRMRAILPWYLDLVTSALGYANETTLRASELTYRELARAILWRALTFLLDFVLAVFVWPWPYEFVVGTRGRSSPVAWRWAVGFRPMEVYVRRSRESWDSVLQEKGMELFDEASKEARAARDAVLGRVREATAPMRIQEKTGYLTMDGEWDLDWKGMADATRLVDKKEIALEAFGTVVLLHHKKFGWLSVDLGMGEAVEQDERRRQVFAFRDALTALGKEDLFFRWVEMIQFETTQPGGFTPEKQVEAAKKIRDMFKSNGVDFDELWKETVGTDGLAGMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GTM1</accession>
    <name>A0AAJ0GTM1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_215117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721742.1">
        <property type="nucleotide sequence ID" value="XM_062862722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GTM1"/>
    <dbReference type="GeneID" id="87881551"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3305962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="235" mass="26397" checksum="39855D4E73C5CECA" modified="2024-07-24" version="1">MSKDRDSSPSYHDRQELGFAGISNSFSSSSEAPMQSPSSHATEVPRHGETSAGDQQKAVRSDSKALATWRERSPSPAPRQLRQIAEEVGRSQKLLQEHRQRQEVASIWKSKYEAVLASAEQKEAEIARLMKQLNSATTAADELRSLLREEIQKNWELQYDLQDAESEVRALREQLMNSIPVRFQGGSGDEDNDNDVEAGLLGGLPWEKYESSRITDLKEELRRVKRDVAIGTSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GTW1</accession>
    <name>A0AAJ0GTW1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_215789</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721777.1">
        <property type="nucleotide sequence ID" value="XM_062862735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GTW1"/>
    <dbReference type="GeneID" id="87881564"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009403">
        <property type="term" value="P:toxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000047">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF230">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3305997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="506" mass="57442" checksum="AE14EFB34FE82C7A" modified="2024-07-24" version="1">MALLHLNIGQIIGLGLAPLTLYITWHILYNLFFHPLRGYPGPVFMRATRWGYNLRLLSGTLPFDMLALHKRYGPVVRVAPDELAFSDPQAWKDIMGHRGSGSGIETGAGSSAAEMEKWDKFYLPIEGIPRDIVNAGREEHALLRRTMAHGFSDRSMREQQPLIKGSIDLLIRRLRERAEDGKVAVDMVAWYNYTTFDVIGDLAFGESFGCLDNADYHPWVKSIFELARGGTVFQSLAHYPILMKLLLALIPAKFLEERERHMQMTLAKLKRRMEAGKERADLVEGLLKRADEWGLTLEKLQVNSSILIIGGSETTATLLSGVTFLLLTNSEVVKKLTGEIRGAFKSEDEINFVSVSTLPYLLACLDEALRIYPPVPTGLPRVVPKGGARICGNYVPEKTVVAIHQWAMYHNDENFRDPFAYRPERWLGDPAFAGDRKVAFQPFHVGPRNCLGRNLAYVEMRLILARILWNFDLSIAEESLDWMRKQRIYNLWEKGKLNVYLTPVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GU31</accession>
    <name>A0AAJ0GU31_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_372454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3306102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721882.1">
        <property type="nucleotide sequence ID" value="XM_062864212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GU31"/>
    <dbReference type="GeneID" id="87883041"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3306102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="233" mass="26547" checksum="A93C08B69E80E41B" modified="2024-07-24" version="1" fragment="single">WKPDETLAAFVDRVYPRWAAPVDDRRSTSIAVGRITAHALAADARIRIEWTDRLTDHLELLVGADWKTVYVFRYPCYLKMCLKALLASKPELDHNTADALALGCLPPDLLVETLSTYNLLFPSTDEASQVMLRDAVKQDHAFAEGFSVFSRGHEGPRDARNPENMADLYKNYPHWAERLDVLWREIENPTPVTRIERWSERRKSARWATWLVVLGLLCALLFGLMATVLGALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GUZ5</accession>
    <name>A0AAJ0GUZ5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Heat shock protein 70 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_509980</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722401.1">
        <property type="nucleotide sequence ID" value="XM_062867835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GUZ5"/>
    <dbReference type="GeneID" id="87886664"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd24094">
        <property type="entry name" value="ASKHA_NBD_HSP70_ScSse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000004">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000011">
        <property type="entry name" value="Heat shock protein hsp88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF4">
        <property type="entry name" value="HSC70CB, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="505"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="743"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="511"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="571"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="592"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="743"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3306621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="796" mass="88001" checksum="89C43D9AF0E0ACD7" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GV56</accession>
    <name>A0AAJ0GV56_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Endoplasmic reticulum protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_151455</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PER33/POM33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722528.1">
        <property type="nucleotide sequence ID" value="XM_062862002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GV56"/>
    <dbReference type="GeneID" id="87880831"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="P:endoplasmic reticulum tubular network organization"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051645">
        <property type="entry name" value="PER33/POM33_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005344">
        <property type="entry name" value="TMEM33/Pom33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12703">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12703:SF4">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03661">
        <property type="entry name" value="TMEM33_Pom33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3306748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="32018" checksum="DD11529FED934DE4" modified="2024-07-24" version="1">MAPPPSADLPLVQRFQRIATTLQFSWFMGHAALLLCVFRYSFSWLRMNYYGGMAQFCYRFAFISAAATYAIVVYKTWRARQKTGAKQPGGVVGYLADENVQYLAMALIWLFMPQYPLALVPYAIYSTFHVATYIRATLIPTIIPPQKINPPEGASPNAKPQYAAHPGSEAIGAFVKRYYDSSMSVVASLEILLWIRLLLSAVLFQRRSWILLGIYTAFLRARFAQSSHVQSSFGQLEARIDNLIGAQGTPPVARQVWDGVKGTARQFHTATDVNKYVNGAAAPKKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GVM3</accession>
    <name>A0AAJ0GVM3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosome 60S biogenesis N-terminal-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_160823</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722781.1">
        <property type="nucleotide sequence ID" value="XM_062862101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GVM3"/>
    <dbReference type="GeneID" id="87880930"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059018">
        <property type="entry name" value="HEAT_URB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039844">
        <property type="entry name" value="URB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032436">
        <property type="entry name" value="URB1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021714">
        <property type="entry name" value="URB1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13500:SF0">
        <property type="entry name" value="NUCLEOLAR PRE-RIBOSOMAL-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13500">
        <property type="entry name" value="NUCLEOLAR PRERIBOSOMAL-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26140">
        <property type="entry name" value="HEAT_URB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16201">
        <property type="entry name" value="NopRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11707">
        <property type="entry name" value="Npa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="URB1 N-terminal" evidence="2">
        <location>
            <begin position="97"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="URB1 central HEAT repeat" evidence="4">
        <location>
            <begin position="631"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="domain" description="URB1 C-terminal" evidence="3">
        <location>
            <begin position="898"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="826"/>
            <end position="852"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF26140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3307001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1138" mass="126224" checksum="74C04430AF50A495" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GVW3</accession>
    <name>A0AAJ0GVW3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_162229</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722814.1">
        <property type="nucleotide sequence ID" value="XM_062862123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GVW3"/>
    <dbReference type="GeneID" id="87880952"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17330">
        <property type="entry name" value="MFS_SLC46_TetA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF15">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="327"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="509"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="21"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="536"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="556"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3307034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="572" mass="61959" checksum="F4248845AE09E7C4" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GW06</accession>
    <name>A0AAJ0GW06_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_156383</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722665.1">
        <property type="nucleotide sequence ID" value="XM_062862059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GW06"/>
    <dbReference type="GeneID" id="87880888"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001113">
        <property type="entry name" value="RNP domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051945">
        <property type="entry name" value="RRM_MRD1_RNA_proc_ribogen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN 14B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039:SF5">
        <property type="entry name" value="RNA-BINDING PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="51"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="239"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="127"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="328"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="180"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="197"/>
            <end position="230"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3306885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="360" mass="38323" checksum="EB6BC062F6ACE4CB" modified="2024-07-24" version="1">MSTAVEKISDAATAAVHDVANTLADISITGKGSDDKSGNNDAVLASAAEGRRLYIGNLAYQTTEGELRDFFKGYLVESVSIPKNPRTDRPVGYAFVDLSTPSEAERAIAELSGTEILERKVSVQLARKPDTNEKTEGANAEGADGARRRQSTRGRGRAGRGRGGRARGGRGSGDEKKQTGAPSAQDPTAASAPQTDVLKDVTNEATGEKDRDAKSGKPQARPRERRERGPPADGIPSKTKVMVANLPYDLTEDKLKELFAAYNPLSAKIALRPIPRFMIKKLQARGEPRKGRGFGFVTLASEELQQKAVAEMNGREIEGREIAVKVAIDSPDKTDDVQAPQGADTNGAEKAEVAPAEATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GW59</accession>
    <name>A0AAJ0GW59_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_510553</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723038.1">
        <property type="nucleotide sequence ID" value="XM_062867860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GW59"/>
    <dbReference type="GeneID" id="87886689"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3307258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="148" mass="16320" checksum="A14B11F676859D2D" modified="2024-07-24" version="1">MAQNESIPVILCGKTFEVGEKVTPLLKPEIEVIHFVNSYEDAKADLGHLLAGRGPQTSTPNHIGSHDYSRPPRAVMFGRAFQADDVKEMHRLYSGKGVGTIAWIAGDPSIVPPENPGPGYAEKAAENVKRAFFKWQEDGANTEEIIWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ0GWB8_9PEZI</name>
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        <submittedName>
            <fullName evidence="3">Mob1/phocein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_163016</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722830.1">
        <property type="nucleotide sequence ID" value="XM_062862129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GWB8"/>
    <dbReference type="GeneID" id="87880958"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="265"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="290"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="432"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="462"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3307050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="513" mass="55216" checksum="0DC14E4412369083" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GWP5</accession>
    <name>A0AAJ0GWP5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_554373</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Sordariomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723321.1">
        <property type="nucleotide sequence ID" value="XM_062870351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GWP5"/>
    <dbReference type="GeneID" id="87889180"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
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        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="36"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3307541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="186" mass="20517" checksum="1DA80CB14A50FAD3" modified="2024-07-24" version="1">MAGNTYVFSQDQHGHLIPYIAALHASCITLDHMVGPFLPPLTNEKLLPWWKERIAEAAHGTRVIVLLLPENSLGKKPQGPDLRGLAMLKLSETETGSFRGHIDAVLVDRRYRRQGGAKALVAALEYEAAKRGRSLLLVDTETGSVAESAFKKFGYIEIGRVPHFSRALPSGKKGETFFYKEFAPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GX41</accession>
    <name>A0AAJ0GX41_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_522453</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Sordariomycetes</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3307748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723528.1">
        <property type="nucleotide sequence ID" value="XM_062868631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GX41"/>
    <dbReference type="GeneID" id="87887460"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3307748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="266" mass="27889" checksum="A87A398312E39C68" modified="2024-07-24" version="1">MKCYDWLMQVPHVKAYCRTSEGNCLVAVGCYEMGGDGHSSWFIFCGTIPRGDLRAYVEDHGGHAAKHWYHAATRDTSGQPVAKLKLHAEDTVLALMNEVMRTLTVKGDAEGIRLLVVGSLYHGRPGLVYLCNGGTKTPSCSIVAERLGVKVIKSGQTVEFFDSQDRLPRYGRGGRGGRGGNGQESGNGNGQGSVSGSAGTGGGHTDRGPHGGSNAVCSSNSGGASYTYRVSRSDHGGNYTQTTADDIAVGMSGLSIGADSTPRSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GXL7</accession>
    <name>A0AAJ0GXL7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_183758</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723380.1">
        <property type="nucleotide sequence ID" value="XM_062862347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GXL7"/>
    <dbReference type="GeneID" id="87881176"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3307600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="226" mass="25030" checksum="7238ECEAB44F689A" modified="2024-07-24" version="1">MPAPIEASKGALSVAQAADILLDSHKASLPRYQAYVRARHRFWEAFPGGLYTRLPTPGTDLECGFHALRLSMLHQLSSSSSSSSSSRSDETAAGIVDRKGIRIPTLEELREVFRGDTVARENERVGMANETWFTADQLAAVFSEWGRRFLGDQEGLRCQLGYVTHDSGGMPVMMNTPWVETGETGEGILRVWVYNDGLSLRGGVGHFEGLRRPTPEETQRILGEYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GY02</accession>
    <name>A0AAJ0GY02_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_100538</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723967.1">
        <property type="nucleotide sequence ID" value="XM_062861351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GY02"/>
    <dbReference type="GeneID" id="87880180"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050320">
        <property type="entry name" value="N5-glutamine_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18895">
        <property type="entry name" value="HEMK METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18895:SF74">
        <property type="entry name" value="MTRF1L RELEASE FACTOR GLUTAMINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3308187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="386" mass="43164" checksum="A6E2DFB3426E3D0D" modified="2024-07-24" version="1">MPRLPPSLFWRARREISPMAAQLLPACRDLESAANELRWIRQHVRDTRSPVPPALRVWRLVEKRGRGVPLQYVLGTQPFGHLEIRCKPGVLIPRPETEAYTLYLASLLCKEQALSTNPPPSLSILDLCTGTGCIPLLLLHSLRQCPSLSQTSLHAHGIDISPHAVRLARLNQAHNHHHLLLSPASSVSKRTTHHDSNLKLEESVEFHFTQADIFSPNLPLPPSYLSQPRRYPHAWDVLTCNPPYISACGFGRDTARGVRNHEPRLALVPPDAGPRPGGLLLAAQYGCRPEDVFYARVLEMAAVLKPRRVVLEVGGWEQARRVVGELLSRRRDVAGLYPTVEIWRDDPDAGEGMTREVVEIGGREVRVIGEGMGRVVYLYHGTKERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GY77</accession>
    <name>A0AAJ0GY77_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_483045</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51220"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <dbReference type="ChEBI" id="CHEBI:34718"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:133977"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 glutathione + H2O2 = glutathione disulfide + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:16833"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="EC" id="1.11.1.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724142.1">
        <property type="nucleotide sequence ID" value="XM_062866141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GY77"/>
    <dbReference type="GeneID" id="87884970"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015038">
        <property type="term" value="F:glutathione disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03419">
        <property type="entry name" value="GRX_GRXh_1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000026">
        <property type="entry name" value="Glutaredoxin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011767">
        <property type="entry name" value="GLR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011899">
        <property type="entry name" value="Glutaredoxin_euk/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02180">
        <property type="entry name" value="GRX_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694:SF18">
        <property type="entry name" value="GLUTAREDOXIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00195">
        <property type="entry name" value="GLUTAREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="8">
        <location>
            <begin position="33"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3308362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="124" mass="13846" checksum="227D9BB5F10356A8" modified="2024-07-24" version="1">MSFIFRRLFGTTSSVTMEAAQKKAQQLIDDNAVMVFSKSYCPYCNNTKRILDELNAKYKAIELNQESDGDTIQDALQQMTGQRTVPNIFINKVHIGGNSDLEDVVKNGKNGKKIEELLKEAGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GYK9</accession>
    <name>A0AAJ0GYK9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Porphobilinogen deaminase</fullName>
            <ecNumber evidence="5">2.5.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Hydroxymethylbilane synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Pre-uroporphyrinogen synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0T15DRAFT_110634</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57845"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="EC" id="2.5.1.61"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>dipyrromethane</name>
            <dbReference type="ChEBI" id="CHEBI:60342"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HMBS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.61" evidence="5"/>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724337.1">
        <property type="nucleotide sequence ID" value="XM_062861497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GYK9"/>
    <dbReference type="GeneID" id="87880326"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004418">
        <property type="term" value="F:hydroxymethylbilane synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.40:FF:000002">
        <property type="entry name" value="Porphobilinogen deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000005">
        <property type="entry name" value="Porphobilinogen deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000086">
        <property type="entry name" value="Probable porphobilinogen deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.40">
        <property type="entry name" value="Porphobilinogen deaminase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00260">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000860">
        <property type="entry name" value="HemC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022419">
        <property type="entry name" value="Porphobilin_deaminase_cofac_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022417">
        <property type="entry name" value="Porphobilin_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022418">
        <property type="entry name" value="Porphobilinogen_deaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036803">
        <property type="entry name" value="Porphobilinogen_deaminase_C_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00212">
        <property type="entry name" value="hemC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557">
        <property type="entry name" value="PORPHOBILINOGEN DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557:SF0">
        <property type="entry name" value="PORPHOBILINOGEN DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01379">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03900">
        <property type="entry name" value="Porphobil_deamC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001438">
        <property type="entry name" value="4pyrrol_synth_OHMeBilane_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00151">
        <property type="entry name" value="PORPHBDMNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54782">
        <property type="entry name" value="Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00533">
        <property type="entry name" value="PORPHOBILINOGEN_DEAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="9" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Porphobilinogen deaminase N-terminal" evidence="13">
        <location>
            <begin position="10"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Porphobilinogen deaminase C-terminal" evidence="14">
        <location>
            <begin position="240"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3308557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="347" mass="37542" checksum="C15AFAAAC04AC309" modified="2024-07-24" version="1">MAPHPEPLTVKVGTRRSALALRQTDQVIDALKQAHPHITFEVHAMATMGDRDKTTPLPALGKGLWTSELEAKLVSRELDMVVHSLKDMPTTLPPGCVLGCVTGREDRRDVLVFSKRHEEEGRCKTLGDLPEGAVVGTSSVRRAAQLKRRYPGLVFRDVRGNIETRLRKCDEEGYDAIILAAAGLLRLDYGKRIAQFLDSSTEGGGLLHAVGQGALGLEVREDDERLKDLLRVVEDTPTMLACFAERSVMRTLEGGCSVPIGVETSWVEAKEEAGGAKKTLRLRATVVSLDGSEAVDGEKTQEITSLAQAETMGKELAEKLAGMGAQKILDDINKGRALGTALKVSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GYS9</accession>
    <name>A0AAJ0GYS9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_508842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cyclase 1 superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724150.1">
        <property type="nucleotide sequence ID" value="XM_062867750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GYS9"/>
    <dbReference type="GeneID" id="87886579"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861:SF10">
        <property type="entry name" value="CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3308370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="336" mass="36814" checksum="4860EB18242BB1EF" modified="2024-07-24" version="1">MDPSSVPDFDDLPPVEGQPQGCAWGIFDKDGKKDVLGTLNFLTPQIVAAAAAEVRDGVSISLNWPLNGIKFPLPGRKPPVHRANPLREMGMDCEGWDDELEFNTQFSSQWDSLCHVTTDGVTYNGLQPTKEGLHVQSTAENPLPTIEHWHARGALAGRGVLIDWKRYHEETTGTPYHPLDGYRITPDDLEKAARHQGVEFKHGDILIVRTGYTEMLAAPTPADFAKFQAGTLSGVHGTVDTARWVWNHRFAAVAGDAHGFEAIPALKPDGTVGGISDLVLHMWFLNQFGMSIGELWDLKALSEYCKKTGRYSFLLTSAPLNHPGLVASPPNALALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GZ55</accession>
    <name>A0AAJ0GZ55_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_118185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724552.1">
        <property type="nucleotide sequence ID" value="XM_062861587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GZ55"/>
    <dbReference type="GeneID" id="87880416"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3308772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="384" mass="40918" checksum="0CC43A7C8F9D9B4B" modified="2024-07-24" version="1">MSHRWPAEPVMDPQYARRRAPPMEQASNAAYTHSRSRTTSSNTFPTGMPAHYPPNPYQPQTHLAEPQMNHQRRSPSVNTFSSISSGGMAPPAAYGTPPTLDIRRSTSSRSGGAPGSPQSSGYVALLRKQKATVWCDRAQYEDPRLLAQQRAAKMRANLAVVGGSGLGIGGVSSGRTSTGLSSTGGKVAAKIRHHGKPTVIGYSPGSNYNGIGGVPLRLSATEVEGEESEEDDAAIQQRLHHRRTGSSGRNSIASGRRTTPYRSSGGLGTTATQHSGSTKWSPSDTPERSGSMVEDKPGEQALAGDDARSGKARSFESGSSGERLDNVPELTTGNTTHFANHSMKHATVTREKSVKSIDELKRRGSVDERAMSLTAGRLYIANPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GZ61</accession>
    <name>A0AAJ0GZ61_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Translation initiation factor eIF 4e-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_120683</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724623.1">
        <property type="nucleotide sequence ID" value="XM_062861620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GZ61"/>
    <dbReference type="GeneID" id="87880449"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.760.10:FF:000016">
        <property type="entry name" value="Translation initiation factor eIF4E, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF66">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E TYPE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="243"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="250"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3308843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="286" mass="31837" checksum="29C53271F6EF6EA3" modified="2024-07-24" version="1">MSTRPSLFTRGLSGLSQQSDPNSPMSVSSPAEQRDDAKRNFLKAMRPLPTQHYWNVWFDRQAKDQQQSKTTDGGNGEYHAQLEQLGDRIESVQDFWRYNNNTPVDQIKMRESIYLFKSGFKPIWEDRRNILGGSWTFRVPKSIGPDVWTRVQLLAIGEKLQSVLEEGDQICGVGLSVRFNSHLISIWHRDASRQGSIDAMLQCVLDELPTELRPTSNNYFYKKHSDHAGFKVPPELQAVIDSQRAREAAAKAAQEQAAAAGPGAGTDAAGQGAAPDIVEVPPSGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GZC6</accession>
    <name>A0AAJ0GZC6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ornithine decarboxylase</fullName>
            <ecNumber evidence="10">4.1.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B0T15DRAFT_122897</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-ornithine + H(+) = putrescine + CO2</text>
            <dbReference type="Rhea" id="RHEA:22964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="4.1.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homodimer. Only the dimer is catalytically active, as the active sites are constructed of residues from both monomers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Orn/Lys/Arg decarboxylase class-II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.17" evidence="10"/>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724704.1">
        <property type="nucleotide sequence ID" value="XM_062861652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GZC6"/>
    <dbReference type="GeneID" id="87880481"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004586">
        <property type="term" value="F:ornithine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033387">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00622">
        <property type="entry name" value="PLPDE_III_ODC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.37.10:FF:000010">
        <property type="entry name" value="Ornithine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000005">
        <property type="entry name" value="Ornithine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="entry name" value="Lyase, Ornithine Decarboxylase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022657">
        <property type="entry name" value="De-COase2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002433">
        <property type="entry name" value="Orn_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482">
        <property type="entry name" value="ARGININE/DIAMINOPIMELATE/ORNITHINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482:SF6">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01182">
        <property type="entry name" value="ORNDCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="Alanine racemase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00879">
        <property type="entry name" value="ODR_DC_2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="6 15" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn/DAP/Arg decarboxylase 2 N-terminal" evidence="16">
        <location>
            <begin position="85"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="398"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="15">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR600183-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK3308924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="461" mass="51249" checksum="CF8AEFC491B55420" modified="2024-07-24" version="1">MVMPTLVTDRFASLDYPEDTNHHVFIKNRNNVFLDNVSQHVHHQDRRGHDAAKQLIGNALRERVESIDYEFCEPGDEDTFFVADLGEVYRQHLRWKMNLPRVRPFYAVKCNPDPKLLELLSALGTGFDCASKNEIEQVLGLGVDPSRIIYAQPCKTNSYVRYVASQGVRQMTFDNADELRKIARLYPEAELFLRILTDDSSSLCRLSLKFGASLDSTDNLLALARELGLNVVGVSFHVGSGASDPGAFLKAVQDAHVVFQQAAAHGFCLRTLDVGGGFCSDNSFEQMAGVLRSALDEYFPAHSGINVIAEPGRYYASSAFTLACNIIARRTIEDVSATSYMVYVNDGLYGNFSSMMFDHQHPVAKVLRARGRTLYNTSAAEATDVVDGIEYSIWGPTCDGIDRITESIRFSVLLDVGDWLYFEDMGAYTMCSATTFNGFTNNHDVIYVCSEPGAKALLDLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H054</accession>
    <name>A0AAJ0H054_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_545043</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725092.1">
        <property type="nucleotide sequence ID" value="XM_062870117.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87888946"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="MFS_dom"/>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
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        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="158"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="385"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="417"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="450"/>
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        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="44"/>
            <end position="472"/>
        </location>
    </feature>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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        <location>
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        <source>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3309312.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H0K5</accession>
    <name>A0AAJ0H0K5_9PEZI</name>
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        <recommendedName>
            <fullName evidence="4">Thymidylate kinase</fullName>
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    </protein>
    <gene>
        <name evidence="12" type="ORF">B0T15DRAFT_391968</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTTP biosynthesis.</text>
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    <comment type="similarity">
        <text evidence="2">Belongs to the thymidylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_062864611.1"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:dTMP kinase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:dTTP biosynthetic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006227">
        <property type="term" value="P:dUDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="TMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Thymidylate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="Thymidylate_kin-like_dom"/>
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        <property type="entry name" value="Thymidylate_kin_CS"/>
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    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00041">
        <property type="entry name" value="DTMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344:SF1">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="THYMIDYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="8 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
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            <begin position="54"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="13"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017144"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3309235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="299" mass="32891" checksum="84B95DFB015FEAC7" modified="2024-07-24" version="1">MASINDLATAAVSALAEAPPPRAPPSSLPDSAQNQIDDRHPREPPVARGALVVLEGLDRSGKTTQVKLLEQRFVELARKVKVMRFPDRTTPIGQMIDSYLKSQVDMDDHVIHLLFSANRWEAAKTITSLLSSGVTVLCDRYYHSGIVYSAAKQNPSLTLSWARAPEVGLPRPDLVLFLDLDESQARLRGGWGGEAYEKAEMQRRVRELFWGLSLGKIETASVIAEEGAVGPKEELAVGPPTTQALTGTEYRFRQEEEDLHVVDASSSVEDVAEEIWKVVKARVEAVERGEVGRAVRKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H0L9</accession>
    <name>A0AAJ0H0L9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Molybdopterin synthase sulfur carrier subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Common component for nitrate reductase and xanthine dehydrogenase protein G</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Molybdenum cofactor synthesis protein 2 small subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Molybdenum cofactor synthesis protein 2A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Sulfur carrier protein MOCS2A</fullName>
            <shortName evidence="3">MOCS2A</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cnxG</name>
        <name evidence="5" type="ORF">B0T15DRAFT_488340</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Acts as a sulfur carrier required for molybdopterin biosynthesis. Component of the molybdopterin synthase complex that catalyzes the conversion of precursor Z into molybdopterin by mediating the incorporation of 2 sulfur atoms into precursor Z to generate a dithiolene group. In the complex, serves as sulfur donor by being thiocarboxylated (-COSH) at its C-terminus by UBA4. After interaction with MOCS2B, the sulfur is then transferred to precursor Z to form molybdopterin.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="3">C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of UBA4, then thiocarboxylated (-COSH) via the rhodanese domain of UBA4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MoaD family. MOCS2A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H0L9"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990140">
        <property type="term" value="C:molybdopterin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030366">
        <property type="term" value="F:molybdopterin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00754">
        <property type="entry name" value="Ubl_MoaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03051">
        <property type="entry name" value="MOCS2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028887">
        <property type="entry name" value="MOCS2A_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF10">
        <property type="entry name" value="TOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="MoaD/ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="4">
        <location>
            <begin position="198"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="modified residue" description="1-thioglycine; alternate" evidence="3">
        <location>
            <position position="733"/>
        </location>
    </feature>
    <feature type="modified residue" description="Glycyl adenylate; alternate" evidence="3">
        <location>
            <position position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3309622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="733" mass="83381" checksum="EBB98D6F3AB6C395" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H0U6</accession>
    <name>A0AAJ0H0U6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_488195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725245.1">
        <property type="nucleotide sequence ID" value="XM_062866482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H0U6"/>
    <dbReference type="GeneID" id="87885311"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052184">
        <property type="entry name" value="SDR_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458:SF3">
        <property type="entry name" value="CHAIN DEHYDROGENASE (ATSC), PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3309465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="246" mass="26511" checksum="0520F2BFFBF8FC88" modified="2024-07-24" version="1">MPSYVITDVSKGLEFEMLRILSKNRQYIVIGLVRGKAATEKAPRPTRAAITGGKLDYLIANGGYVPQWDAYDPIGELAEEADMVSEKLAKLYQTNIAGNIQLCRYFLPLILRGDVKKVIAFLSGLADLNSLNGLGLTNSPLYALTTAGLNVLMAKYSAQYKKDGVLFVSIWPGMVDVGHFDNAGSSQGHGGQVQGGHTRLPGPTKPDVAMQNVINLWEKASIENGIQGAQGGNLQLHRLLVQSTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H0W1</accession>
    <name>A0AAJ0H0W1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_570468</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725539.1">
        <property type="nucleotide sequence ID" value="XM_062870836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H0W1"/>
    <dbReference type="GeneID" id="87889665"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3309759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="298" mass="32643" checksum="A6E49FDF1339DCB3" modified="2024-07-24" version="1">MAGVPCGNSTVCKAGTYGETLRDKMSGPPIQPPAMARRQELLVVPLLLSQPPVGTVTTTSKLEGQSKASETSKDIVEVLYLDICMGVFVWRFLLAGGLSGNLSLLENFEEERRKVTLDLVSFDSRFNSNEGFVLVEFPTSRSPRGPSSSRTSIRLSSTSDDVLSADLDSQSRQIVSAGTLFISSPSTLAKQRMIAVVGSHSVGKSSLAVRYVDGHFVESYYPSIGSTISKEFHGYIRHSMRMLLLRPQLQPSIKTLLDDVVVKFGSRFIRSLVSGQHTQPSIGAEIRGRDHRLGRYCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H166</accession>
    <name>A0AAJ0H166_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_18727</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725718.1">
        <property type="nucleotide sequence ID" value="XM_062862395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H166"/>
    <dbReference type="GeneID" id="87881224"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3309938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="208" mass="22942" checksum="5ECA9F66698D43F6" modified="2024-07-24" version="1">MYDRPVEQIFTEYTIKCTRDNGNLDILSDVEDSSLRTIPGLPSWVPGFSFPLTLTQWLRGRQARTKVSNRHLGCQGGWSAQNGGADIALAGCPIGGRFALASKESAAENMIIHQLQEWAAMIEPMPADYPSGCHKALIRDRGDEDQYPAPVEYGDYYETLQELIQLNQDLDRRIESGEDGGAAARILCQGSGIHPADLPRLMAESAEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H185</accession>
    <name>A0AAJ0H185_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SIN3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_498130</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725719.1">
        <property type="nucleotide sequence ID" value="XM_062867304.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87886133"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000001">
        <property type="entry name" value="Paired amphipathic helix protein Sin3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000002">
        <property type="entry name" value="Paired amphipathic helix protein SIN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000003">
        <property type="entry name" value="Paired amphipathic helix SIN3-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1160.11">
        <property type="entry name" value="Paired amphipathic helix"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013194">
        <property type="entry name" value="HDAC_interact_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003822">
        <property type="entry name" value="PAH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036600">
        <property type="entry name" value="PAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039774">
        <property type="entry name" value="Sin3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031693">
        <property type="entry name" value="Sin3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346:SF0">
        <property type="entry name" value="SIN3A, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346">
        <property type="entry name" value="SIN3B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02671">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08295">
        <property type="entry name" value="Sin3_corepress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16879">
        <property type="entry name" value="Sin3a_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00761">
        <property type="entry name" value="HDAC_interact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47762">
        <property type="entry name" value="PAH2 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51477">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase interacting" evidence="9">
        <location>
            <begin position="716"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="352"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="505"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1005"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="12"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="103"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="360"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="406"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="572"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1005"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1072"/>
            <end position="1081"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3309939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1488" mass="166445" checksum="4AAC5ADA8DB6948D" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H1K5</accession>
    <name>A0AAJ0H1K5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AA1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_25189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725899.1">
        <property type="nucleotide sequence ID" value="XM_062863191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H1K5"/>
    <dbReference type="GeneID" id="87882020"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042586560" description="AA1-like domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3310119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="171" mass="18283" checksum="48B2A2B3DD5015FE" modified="2024-07-24" version="1">MLRSVFALAAVAHLSAASPTYKIPLAMSKAMLESDGCILPEAFVVQNFYIWTPSAGNNSSRVINFDYADNSTSINTKCHFNATSVNVGSEGLAPRYACDNTVVQFIWEDERLTMIEKACPENSQFEAAGSVTPHLVCSKSAVNSTVGAGNACSSMQKSMAANFTSLQPTPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H2B9</accession>
    <name>A0AAJ0H2B9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Vacuolar fusion protein MON1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_41552</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">In complex with CCZ1, is required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis. The MON1-CCZ1 complex acts at the fusion of vesicles with the vacuole, through its regulation of the SNARE complex during the coordinated priming and docking stages of fusion, and particularly at the stage of tethering/docking.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endosome</location>
            <location evidence="4">Multivesicular body membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 4">Prevacuolar compartment membrane</location>
            <topology evidence="1 4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Vacuole membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MON1/SAND family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726323.1">
        <property type="nucleotide sequence ID" value="XM_062865462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H2B9"/>
    <dbReference type="GeneID" id="87884291"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035658">
        <property type="term" value="C:Mon1-Ccz1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032585">
        <property type="term" value="C:multivesicular body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043972">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043971">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043970">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004353">
        <property type="entry name" value="Mon1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13027">
        <property type="entry name" value="SAND PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13027:SF7">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN MON1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19036">
        <property type="entry name" value="Fuz_longin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19037">
        <property type="entry name" value="Fuz_longin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19038">
        <property type="entry name" value="Fuz_longin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01546">
        <property type="entry name" value="YEAST73DUF"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="FUZ/MON1/HPS1 first Longin" evidence="6">
        <location>
            <begin position="181"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="FUZ/MON1/HPS1 second Longin" evidence="7">
        <location>
            <begin position="343"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="FUZ/MON1/HPS1 third Longin" evidence="8">
        <location>
            <begin position="511"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="425"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF19036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF19037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF19038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3310543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="627" mass="68086" checksum="90682CC5561E8461" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H2R1</accession>
    <name>A0AAJ0H2R1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutaredoxin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_37379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726200.1">
        <property type="nucleotide sequence ID" value="XM_062864217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H2R1"/>
    <dbReference type="GeneID" id="87883046"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008554">
        <property type="entry name" value="Glutaredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052565">
        <property type="entry name" value="Glutaredoxin-like_YDR286C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33558">
        <property type="entry name" value="GLUTAREDOXIN-LIKE PROTEIN C5ORF63 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33558:SF1">
        <property type="entry name" value="GLUTAREDOXIN-LIKE PROTEIN C5ORF63 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05768">
        <property type="entry name" value="Glrx-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3310420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="105" mass="12214" checksum="7265939AC492AD23" modified="2024-07-24" version="1">MRVTGRLLHSCRITLFTRENCGLCSQARSVLSDVWDKRPFAFKEVDIIKPESRAWRDLYDFDVPVIHISKTQSPDEDPKLSSKATRLMHRFTVDEVMAKMDSVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H2T0</accession>
    <name>A0AAJ0H2T0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Acyl-CoA dehydrogenase/oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_49736</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726561.1">
        <property type="nucleotide sequence ID" value="XM_062867259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H2T0"/>
    <dbReference type="GeneID" id="87886088"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008470">
        <property type="term" value="F:3-methylbutanoyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000021">
        <property type="entry name" value="Isovaleryl-CoA dehydrogenase IvdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000003">
        <property type="entry name" value="isovaleryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000004">
        <property type="entry name" value="Isovaleryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF18">
        <property type="entry name" value="ISOVALERYL-COENZYME A DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016578">
        <property type="entry name" value="HsaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="9">
        <location>
            <begin position="67"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="8">
        <location>
            <begin position="181"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="7">
        <location>
            <begin position="288"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3310781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="446" mass="47946" checksum="28E0C331F3870D62" modified="2024-07-24" version="1">MASPTISRALARAMPRRQLGVSHASRPSSLASTSHRAARSAFALQQRRNASSSKHPKGFEPPSPSDLAELRERVHEFTRRELTEEVAAATDKNNNFPPDMWGKLGEAGFLGITADEDVGGLAMGYQAHCVVMEELSRASGSIALSYAAHSQLCVNQLQLNGSPEQKQKYLPDLISGQTVGALAMSESGSGSDVVSMRTRATEVDGGYVLNGSKMWITNGPDADVVVVYAKTVPDGGSKGITAFIVETKTPGFACLRKLDKMGMRGSNTGELVFENVFVPRENVLGQINGGVRVLMEGLDLERLVLSAGPLGLMQAALDVALPYAHSRKQFGTPIGQFQFVQGKLADMYTKLQASRAYTYATARAVDEQGLIKTQDCAGAILYAAERATECALDCIQVLGGMGYTEEMPASRILRDAKLYEIGAGTSEVRRMVIGRAFNKEYAHLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H358</accession>
    <name>A0AAJ0H358_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_520063</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726767.1">
        <property type="nucleotide sequence ID" value="XM_062868470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H358"/>
    <dbReference type="GeneID" id="87887299"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="BPL/LPL catalytic" evidence="5">
        <location>
            <begin position="61"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3310987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="210" mass="22302" checksum="AA5F47C6E303A954" modified="2024-07-24" version="1">MTISIGSSAQWRQILSSHSIVIVDFYADWCGPCKMIAPTFESLSTKYSKPNKIAFCKVDVDNQRDVAQQYGVRAMPTFLVLRNGSVIETIQGANPPALTAAVEKAVKLAGPGGGGGGGATFSGSGQRLGGSGVGPKTVRRPMRWALKPVLEAVIAFFGLYFWSLFSLDPYKSAENSPFNKINPPARVQSGTGTRLAARPGFKTLADLGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H3G1</accession>
    <name>A0AAJ0H3G1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Superoxide dismutase [Cu-Zn]</fullName>
            <ecNumber evidence="4 12">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0T15DRAFT_482012</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="12">Binds 1 copper ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="4 12"/>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726575.1">
        <property type="nucleotide sequence ID" value="XM_062866065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H3G1"/>
    <dbReference type="GeneID" id="87884894"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00305">
        <property type="entry name" value="Cu-Zn_Superoxide_Dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.200:FF:000001">
        <property type="entry name" value="Superoxide dismutase [Cu-Zn]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018152">
        <property type="entry name" value="SOD_Cu/Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="SUPEROXIDE DISMUTASE CU-ZN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00068">
        <property type="entry name" value="CUZNDISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00087">
        <property type="entry name" value="SOD_CU_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00332">
        <property type="entry name" value="SOD_CU_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="10 12" id="KW-0186">Copper</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Superoxide dismutase copper/zinc binding" evidence="14">
        <location>
            <begin position="14"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="125"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3310795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="154" mass="15935" checksum="568440613AF4891E" modified="2024-07-24" version="1">MVKAVAVVRGDSKVTGTVVFEQESESAPTTVTWDITGHDPNAKRGMHIHTFGDNTNGCTSAGPHFNPHGKTHGAPTDENRHVGDLGNIETDAQGNSKGSVTDKFIKLIGPESVIGRTVVVHAGTDDLGKGGNEESLKTGNAGPRPACGVIGISQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H3K3</accession>
    <name>A0AAJ0H3K3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">uS12 prolyl 3,4-dihydroxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0T15DRAFT_489792</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + 2-oxoglutarate + O2 = [ribosomal protein uS12]-(3S)-3,4-dihydroxy-L-proline + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:54160"/>
            <dbReference type="Rhea" id="RHEA-COMP:13817"/>
            <dbReference type="Rhea" id="RHEA-COMP:13818"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:85428"/>
            <dbReference type="ChEBI" id="CHEBI:138052"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[ribosomal protein uS12]-L-proline + 2-oxoglutarate + O2 = [ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:54156"/>
            <dbReference type="Rhea" id="RHEA-COMP:13816"/>
            <dbReference type="Rhea" id="RHEA-COMP:13818"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:50342"/>
            <dbReference type="ChEBI" id="CHEBI:85428"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726946.1">
        <property type="nucleotide sequence ID" value="XM_062866626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H3K3"/>
    <dbReference type="GeneID" id="87885455"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031543">
        <property type="term" value="F:peptidyl-proline dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009896">
        <property type="term" value="P:positive regulation of catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010604">
        <property type="term" value="P:positive regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006449">
        <property type="term" value="P:regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000014">
        <property type="entry name" value="Prolyl 3,4-dihydroxylase TPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019601">
        <property type="entry name" value="Oxoglutarate/Fe-dep_Oase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039558">
        <property type="entry name" value="TPA1/OFD1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051842">
        <property type="entry name" value="uS12_prolyl_hydroxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12117">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12117:SF0">
        <property type="entry name" value="PROLYL 3-HYDROXYLASE OGFOD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13661">
        <property type="entry name" value="2OG-FeII_Oxy_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10637">
        <property type="entry name" value="Ofd1_CTDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0847">Vitamin C</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="14">
        <location>
            <begin position="143"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="293"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="464"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="626"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="298"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="488"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="527"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="626"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="657"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00081607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3311166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="668" mass="74285" checksum="DF5D39C3491CD39B" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H3M6</accession>
    <name>A0AAJ0H3M6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_547824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726680.1">
        <property type="nucleotide sequence ID" value="XM_062870185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H3M6"/>
    <dbReference type="GeneID" id="87889014"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="640"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="706"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="788"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="788"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="809"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="827"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="841"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="882"/>
            <end position="894"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3310900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="987" mass="107817" checksum="2355153EC18EDDF6" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H3Y6</accession>
    <name>A0AAJ0H3Y6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA polymerase II transcription elongation factor-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_72778</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727159.1">
        <property type="nucleotide sequence ID" value="XM_062871256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H3Y6"/>
    <dbReference type="GeneID" id="87890085"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019194">
        <property type="entry name" value="Tscrpt_elong_fac_Eaf_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09816">
        <property type="entry name" value="EAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription elongation factor Eaf N-terminal" evidence="2">
        <location>
            <begin position="15"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3311379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="384" mass="42214" checksum="9A2EF9195D3B5D0E" modified="2024-07-24" version="1">MATPGIIDPTKAGQYPVILSDALLGKASNETYTGIRYNHRPTLSSDSAPSTARLKRSAKDESYNLGFDDQGDKYQYNGVRTHDDGNYVLIFDPTRKAFVLHRVDSTFHMNITRTPTESNAANLRKQFPHLEITSSIPAKKPRVKATEKANTTNTTNSTNSTPSKAKDGASSKPDKKAVALTLPTLSGTPASSGSPSSQQLEKKSEPPAAQSDQEKKPKRRALSPVESEEEDEDDGDDVLTLEIPQGNPDAFRGSNFSGTMPVSLTRRFSEFARDMERETDEDDDTRMEEELEAGYEEEDEDEGEDEEPPRQPPVQGSHTKTENLVAVEPEVYTFDDGDDDSNADAGGNDALDQDFGDLEAELERELEMVQNEGHESDSSVSEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H443</accession>
    <name>A0AAJ0H443_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Prefoldin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_65811</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726970.1">
        <property type="nucleotide sequence ID" value="XM_062871162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H443"/>
    <dbReference type="GeneID" id="87889991"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23164">
        <property type="entry name" value="Prefoldin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20903:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20903">
        <property type="entry name" value="PREFOLDIN SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3311190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="121" mass="13309" checksum="E19CD1A7E1C240F4" modified="2024-07-24" version="1">MSISNEALQKLLREVETQAIAAQQQISLVRTQVASKQREMRLAQLTRSEIASLPPDTAVYEGVGKMFVAVPVPALQEKLGGQMKDIETEVDALGKRLHYLETTAKNSQEHIEKILKGGGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H551</accession>
    <name>A0AAJ0H551_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein S16 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_387968</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727450.1">
        <property type="nucleotide sequence ID" value="XM_062864416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H551"/>
    <dbReference type="GeneID" id="87883245"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00385">
        <property type="entry name" value="Ribosomal_bS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000307">
        <property type="entry name" value="Ribosomal_bS16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020592">
        <property type="entry name" value="Ribosomal_bS16_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023803">
        <property type="entry name" value="Ribosomal_bS16_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00002">
        <property type="entry name" value="S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919:SF20">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS16M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00886">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54565">
        <property type="entry name" value="Ribosomal protein S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00732">
        <property type="entry name" value="RIBOSOMAL_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="101"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3311670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="116" mass="13052" checksum="A2BBAED8C666A227" modified="2024-07-24" version="1">MVVKIRLARFGRTNHPFYNIVVAHARTARNSRPLEVIGTYDPIPKKDPYDDSGRLHKDIKLDITRAKYWIGVGAQPTDTMWRLLSMVGILPPKYRPAAPAPSQNTQSTPQASRSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LXS9</accession>
    <name>A0AAJ0LXS9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Aspartic peptidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_405055</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717462.1">
        <property type="nucleotide sequence ID" value="XM_062865281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LXS9"/>
    <dbReference type="GeneID" id="87884110"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05474">
        <property type="entry name" value="SAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033876">
        <property type="entry name" value="SAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF65">
        <property type="entry name" value="ASPARTIC-TYPE ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042529885" evidence="9">
        <location>
            <begin position="22"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="10">
        <location>
            <begin position="65"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="443"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="456"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="313"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3301682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="495" mass="51538" checksum="25520DC8273756C1" modified="2024-07-24" version="1">MAVSFLFSASVLLIALFCCHATALQQTTHDTGCIHLPVVHSTNVNYFSSKRGVQLQLANRSDVAYYAQLSIGTPPQPVFVQLDTGSFELWVNPDCTTVSGADAVFCERAGQYDTTKSSTATSLGTTRTLRYGIGSANITYFTDTVTLAGSPTALQGVQFGVATASEDAFSGILGIGYGKGIATRYLNFVDQLRAQNVTRVKAYTLALGSKDAQEGVIVFGGIDTSKFAGSLVKLPIIPAQQSPDGVPRFWVGLKSVSITPPNGVNRAYDDSSTPVFLDSGSTMTLLPPNLTRAIARDFGVQEPDSNGFFRIDCSLAALNGTLDFAFDGVTIKVPYKELTREVSSNPPACFLGIMPSERFTLLGDTFLRSAYAVFDLETDGIWMAQATDCGSSPAALGNIQDLSAVTGACGVTASAVNGASGTPIASPGVESVEAVPVPSVVPPTIGLPPASGTAQGTASQGSPSPTSSTGCGPQSPIGRVWSLGIMVLLHILLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LXU6</accession>
    <name>A0AAJ0LXU6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_544460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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            <end position="224"/>
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            <end position="138"/>
        </location>
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        </source>
    </evidence>
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</entry>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
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                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
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                <person name="Lalanne C."/>
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                <person name="Ament-Velasquez S.L."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
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                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
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                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
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    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
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        <submittedName>
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        </submittedName>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Hiltunen Thoren M."/>
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        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <person name="Labutti K."/>
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                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF85">
        <property type="entry name" value="DUF803 DOMAIN MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G15880)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    </feature>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3302343.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ0LYN2_9PEZI</name>
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        <recommendedName>
            <fullName evidence="4">DNA-directed DNA polymerase</fullName>
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        </alternativeName>
    </protein>
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    <organism evidence="17 18">
        <name type="scientific">Chaetomium strumarium</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Involved in the replication of mitochondrial DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 19">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA polymerase type-A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="4"/>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718228.1">
        <property type="nucleotide sequence ID" value="XM_062869953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LYN2"/>
    <dbReference type="GeneID" id="87888782"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005760">
        <property type="term" value="C:gamma DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006264">
        <property type="term" value="P:mitochondrial DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08641">
        <property type="entry name" value="DNA_pol_gammaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000035">
        <property type="entry name" value="DNA polymerase gamma, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.390:FF:000003">
        <property type="entry name" value="DNA polymerase gamma, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.390:FF:000006">
        <property type="entry name" value="DNA polymerase gamma, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019760">
        <property type="entry name" value="DNA-dir_DNA_pol_A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002297">
        <property type="entry name" value="DNA-dir_DNA_pol_A_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041336">
        <property type="entry name" value="DNApol_Exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047580">
        <property type="entry name" value="POLG_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10267">
        <property type="entry name" value="DNA POLYMERASE SUBUNIT GAMMA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10267:SF0">
        <property type="entry name" value="DNA POLYMERASE SUBUNIT GAMMA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18136">
        <property type="entry name" value="DNApol_Exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00867">
        <property type="entry name" value="DNAPOLG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00447">
        <property type="entry name" value="DNA_POLYMERASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family A palm" evidence="16">
        <location>
            <begin position="706"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="478"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1077"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1089"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1099"/>
            <end position="1113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00057053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK3302448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1175" mass="132225" checksum="6DF0AEAA0AC2472D" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LYU0</accession>
    <name>A0AAJ0LYU0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_543376</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718393.1">
        <property type="nucleotide sequence ID" value="XM_062869989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LYU0"/>
    <dbReference type="GeneID" id="87888818"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF106">
        <property type="entry name" value="NIMA-LIKE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="285"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="325"/>
            <end position="424"/>
        </location>
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        </source>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3302613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="424" mass="46351" checksum="E0558F197D21D3CB" modified="2024-07-24" version="1">MACKIVQAHHDPIMRVYQQRELGIWYKACRGARNVAMIYDAAYNARDGTAYIYMELLPGGDTWNLGGKIVSNGDVMHPLLLTTIAYQTALGLAEIHGRKLQHRDLKPDNILLTKKITPGMNKALWELERKGRPSSAHRDDLVEAYNILREPRLAVLTDFGLAHDHAAPAANHGIATKMGGFSAAYNAPEMVEGNNDQSPWADVFSFGLCIYMLSTMRFLKHHSERGNLPKTYSSDLQRLYLGCTQEDWERRPIAIEAASKLQEIQKAEMASIAKLYTAWKASERSAPAAQGSSRPVASSSRGGGGGGGMSAEHKRLIAAEMAQVEVERKRDDARRAAARGGGGGARGGTGGVTEAMGRLRVADDRNTRNAGNTPYYGGTSQQQGTRPAARRPEDASRRVAQGQSTRTGGGGSSRDYDGYDRYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ0LZ65_9PEZI</name>
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            <fullName evidence="5">Protein sip5</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">B0T15DRAFT_263649</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
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                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
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                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
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                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
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                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
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                <person name="Barry K."/>
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                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 333.67</strain>
        </source>
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    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Cros-Aarteil S."/>
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
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                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
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                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIP5 family.</text>
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    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
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                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
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                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
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                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
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                <person name="Cros-Aarteil S."/>
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                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
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                <person name="Chen C."/>
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                <person name="Daum C."/>
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                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_062869728.1"/>
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    <dbReference type="GeneID" id="87888557"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3303166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="272" mass="28838" checksum="AD7DD08044876F24" modified="2024-07-24" version="1">MWADEPELVTGTRLSMTAAGSLDGDMDMMDTSEPASGPYQPSFQGQPVTEPASFQRDQSGPSVSGRMPTPIQPTFAAQIRGKSWNGGNATHGDALATTPEEPNAASFGRNELVDISPQPLGGAAASQVMTDWSMVQNRRLPSPISECGGDDSLESTRMALDSSTLSEGPLSHLTHEHPLLAGLPPRASSAMEGRSVRQATPASENLSGSAMDVEAPAATSPPKKGHTRSKHTVNSWTALQPGMKRSFSIGYRADCEKCRMKVPGHFNHIIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZM9</accession>
    <name>A0AAJ0LZM9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_576878</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719339.1">
        <property type="nucleotide sequence ID" value="XM_062871044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZM9"/>
    <dbReference type="GeneID" id="87889873"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF7">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="226"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="179"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="609"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="660"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="179"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="210"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="665"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3303559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="680" mass="75210" checksum="56A9EC304404351F" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZV3</accession>
    <name>A0AAJ0LZV3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_513931</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719580.1">
        <property type="nucleotide sequence ID" value="XM_062868083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZV3"/>
    <dbReference type="GeneID" id="87886912"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF224">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="266"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="301"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="52"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3303800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="457" mass="48976" checksum="B4429937C93DE965" modified="2024-07-24" version="1">MSFEKAAPTDTDTGEGVFQSPDESQLSQGPDNKSDNEVQLQADSGPPDGGTGAWLAVLGAWCCSFNSFGWMNSVGVFQSYYEFGPLKDYDSSTISWIPSLEIFFLFFLGPAVGFLFDKYGPTPLILVGTFLHVFGLMMASLATEYYQFLLAQGVCSAIGLSFLYSPAISTIATWFQKKRGLAMGVMVTGSSIGGVVFPIMINRLIQNPSTGYPWAMRIAAFLILALQIVAIFTLRPRTAPGPKKTVAVSNAGRAATLAAPFKEFPFVVMLVGMFILMYGIFIPVNYLALQALEEAHVSESMSLYLVAIFNGASLFGRLGSGYWSDIAGRWNVFVLAGATSGIVELALWIPATYQSAAIGFAVTFGFLSGAFVSLLAALPASVSPLPQIGYRIGVVMLVLSVPALTMAPIGGRILQSASSVENGWLHVKIFGGVMSLAGSAVVFYARVLYSKKFWAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZW9</accession>
    <name>A0AAJ0LZW9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lactonase, 7-bladed beta-propeller-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_504989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cycloisomerase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719624.1">
        <property type="nucleotide sequence ID" value="XM_062867517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZW9"/>
    <dbReference type="GeneID" id="87886346"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050282">
        <property type="entry name" value="Cycloisomerase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344:SF1">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3303844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="397" mass="41728" checksum="5AB3A6C96ACA02B5" modified="2024-07-24" version="1">MSTYSTMARLTQIVAGIALAPGALGAALIASHFAGGVYTLDFAGTNTSGTLSMVSQTSGCGTTPGWIELYSDSGKLYCFDESWTGRGVISEYNVASDGRLTLTGQARTTGNTVHGVLYGGADGRGFVATAEYSPSTITTYKMPLLSSAVLQLEKFTMAQRGPNPRQDVPHPHEVHLDPTGKFIITPDLGADVVRIFKIDATSGKLTACSEGKADAGDGPRHIEFWKSAAGVQKAYTVNELGNSVSAWDVTYPSSNGSGCLSLKKTQTLSTYAPGKKGGPTTKAAEIRVVGNFLYATNRADQTFGSQQDSIATYTINPTTGALAWLEAANSYSYYPRTFQFNKNGTLLAVGGQTSSNVAIIARDPATGRLGKLVANLQVGQKGRAGEEDGLSAVVWVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZY4</accession>
    <name>A0AAJ0LZY4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_223622</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3303890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719670.1">
        <property type="nucleotide sequence ID" value="XM_062862841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZY4"/>
    <dbReference type="GeneID" id="87881670"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF49">
        <property type="entry name" value="LYSINE BIOSYNTHESIS REGULATORY PROTEIN LYS14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="9"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3303890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="518" mass="57628" checksum="8A3D0B3007EDF008" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M0S2</accession>
    <name>A0AAJ0M0S2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Permease for cytosine/purines, uracil, thiamine, allantoin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_537544</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720551.1">
        <property type="nucleotide sequence ID" value="XM_062869626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M0S2"/>
    <dbReference type="GeneID" id="87888455"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015851">
        <property type="term" value="P:nucleobase transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000002">
        <property type="entry name" value="Purine-cytosine permease fcyB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF7">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G04690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="296"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="388"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="459"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="502"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3304771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="524" mass="56601" checksum="C31F890825D17AC9" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M0X0</accession>
    <name>A0AAJ0M0X0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_512990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720687.1">
        <property type="nucleotide sequence ID" value="XM_062868017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M0X0"/>
    <dbReference type="GeneID" id="87886846"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042528243" description="CR-type domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3304907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="154" mass="16104" checksum="EAD39D2724F3D3A5" modified="2024-07-24" version="1">MGHIAFSLVIGWVTVSSRGSGSGAPAYAGRSSGLRTGSGSGGSSGGSRPSSRGSGDSQKFDPCCDYCRGSGKYTVQKSEQLRCTACGGSGGSYRQVPCTNCYKGKMSIKGPVGPKCNRTCTVNGPRRTCNTCFGLGHTTRVWTEEYICDCKGYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M190</accession>
    <name>A0AAJ0M190_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Six-hairpin glycosidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_531747</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721034.1">
        <property type="nucleotide sequence ID" value="XM_062869274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M190"/>
    <dbReference type="GeneID" id="87888103"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052043">
        <property type="entry name" value="PolySaccharide_Degr_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33886">
        <property type="entry name" value="UNSATURATED RHAMNOGALACTURONAN HYDROLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33886:SF8">
        <property type="entry name" value="UNSATURATED RHAMNOGALACTURONAN HYDROLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="77"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3305254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="505" mass="57155" checksum="9FD219B1B1AB89C5" modified="2024-07-24" version="1">MVRFTDERVWGPDPLADSTGSDPWFPLSSSPCLPPRHRCTPRRNRPRALSSSSKNPPPDFRVSGWLTRGYFSTKHDPRTGDDFLKSAESTGSQSKGKKRLEREELRINRPLALERLPQKEKKKKTSKMPTSHAGIASADIHAKIELLISALVNIRDSTGEFLLTLPDGRVIDTKGWHDWEWTHGIGLYGIWQYYCLTQSPRHLGIIEAWFRDRFAAGGTTKNINTMSVFLTLACVYEHTGNKRYLPWLDGWAEWAYHDLVRTKHGGMQHITYLEENRQQLWDDTLMMTVLPLAKIGLVLGRPHYVDEAKRQFLLHIQYLFDAKTGLFFHGWEFNETGPGGHNFAEARWARGNSWLTIAIPEFLELLSEAGVRDVAFEQVLRSTLQAQCEALRPLQIAETGLWRTLLDVPESEGSYPEASATAGFAYGALKGQRKKYVGGEFEEMAVRAVRGVLANVSAEGELLNTSFGTGMGRDLQHYKDIPVTSMPYGQAMAIMALVEFARRYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M275</accession>
    <name>A0AAJ0M275_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6604 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_509739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722130.1">
        <property type="nucleotide sequence ID" value="XM_062867805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M275"/>
    <dbReference type="GeneID" id="87886634"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046539">
        <property type="entry name" value="DUF6604"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795:SF1">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20253">
        <property type="entry name" value="DUF6604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6604" evidence="1">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3306350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="467" mass="52734" checksum="928FA71D471CFB31" modified="2024-07-24" version="1">MAELVAKRKLALRSSIAKVLERVICLREAFAQLLQERGVVNAEEVTARKHSHFVDILKQVHNILGGAHRINASTGSIAPPSPRQCLSTAFAALRLYEPSHQFLDAPDVTLPAPEYDIAEDEAGLEEAATAIDLARKMEEKAAPVLDRFGGVAKFIVDHYHTAASAEGLDPSHRVADGDDINIDAYGISKRTMYEAYHLLDRIRKACLEDPEMPPLYNGQPYGWFQPGKVHKSHSAHERYDRDCAGFAEVVSETAILARKLKWSSVQDEFTRGDRLIMADPSQPIPFWVVFASQLFIDNFEILGDQLENGWTDVISKWKRRLLPSIVKPQSILVKRNAVFAGVWAHHLLTLFHTTAIAFVNVWGAVFAMNQFYHAMIRLTWMATRSHPKPGDRRFWVGQEPQEIKDFWKQWCLCNDTAGHARVNMTLEDVRNIVGEGGWIEVDPSPGNVYEMVHEYDRASSRPFREAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M2F0</accession>
    <name>A0AAJ0M2F0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="8">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_527567</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="8"/>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722340.1">
        <property type="nucleotide sequence ID" value="XM_062868983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M2F0"/>
    <dbReference type="GeneID" id="87887812"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF20">
        <property type="entry name" value="[3-METHYL-2-OXOBUTANOATE DEHYDROGENASE [LIPOAMIDE]] KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="280"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="314"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3306560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="460" mass="50814" checksum="BD6AB027804F570C" modified="2024-07-24" version="1">MRGSIVRPLRYSRSAIPQINCWRRASSTLQHLKNASTAHHRPQHHHPHEREHDFVPHLAKQPLHPLSLADLVKHGRPPLSADALLASARFTLSLLPIRLAHRIQALRNLPYIVVSNPNISRIYNNYQHSLSTLLPWQGRTISNLEDEIRFTEVLAELVQTHTDTIPILARGFLECRKYISPAEVTRFLDEHLRARIGTRLVAEQHIALHFSSTPHFDPAASPTPCPEHPSYIGVIDTALRPALTIDSCGGFVADICELNYGVRPRWIVDGEPDTTFAFVPMHLEYIVTELLKNAFRATVENGMNREPVVITIAPEPPAVKPPPPQQGQVRLEPPRESRGAFDRDAIAPLDDNAPGVTIRIRDRGGGIGPDVLPHIWSYSFTTFSESDDDVPGGSSSWTGGDALNVISAASHGRSSIAGLGYGLPLSRAYAEYFGGGIAVQSLHGWGTDVYLRLKGVGKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M2K7</accession>
    <name>A0AAJ0M2K7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ClpP/crotonase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_431625</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722546.1">
        <property type="nucleotide sequence ID" value="XM_062865739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M2K7"/>
    <dbReference type="GeneID" id="87884568"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000074">
        <property type="entry name" value="Enoyl-CoA hydratase (AFU_orthologue AFUA_2G10650)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF158">
        <property type="entry name" value="ENOYL-COA HYDRATASE (AFU_ORTHOLOGUE AFUA_2G10650)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3306766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="283" mass="30405" checksum="C267EA8469DA3B0B" modified="2024-07-24" version="1">MTLSPTLSPPPEVPNVLLSLPHPNVLLVTLNRPRALNAIPSFQHVAMASLWAWYDAQPQLRCAVLTGGADARAFCAGADLREWDATHASSNNGTSSSKRWSQEGFGGLSNRTGKKPVIAAVNGLCFGGGMEMVINCDLVVADGKRARFGLPEVKRGVVAVAGALPRLVRTVGRQRAAEMALLGRTGYTAEQMREWGIVNFVVAEGQAVAEAIKLAEEIAANSPDSVITSREGLRLGWEGIGPQMGTEVLERGMYGRIDGGENMKEGVKSFVERREPVWKDSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M2T0</accession>
    <name>A0AAJ0M2T0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Clasp N terminal-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_413739</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Microtubule binding protein that promotes the stabilization of dynamic microtubules. Required for mitotic spindle formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLASP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722756.1">
        <property type="nucleotide sequence ID" value="XM_062865429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M2T0"/>
    <dbReference type="GeneID" id="87884258"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060172">
        <property type="term" value="P:astral microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024395">
        <property type="entry name" value="CLASP_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567">
        <property type="entry name" value="CLASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567:SF9">
        <property type="entry name" value="CLIP-ASSOCIATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12348">
        <property type="entry name" value="CLASP_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TOG" evidence="9">
        <location>
            <begin position="1"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="9">
        <location>
            <begin position="281"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="234"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="507"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="573"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="736"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="534"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="573"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="595"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="699"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="769"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3306976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1129" mass="121784" checksum="9BAB3DA91D40E079" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M2Y2</accession>
    <name>A0AAJ0M2Y2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL44</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_529091</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ribonuclease III family. Mitochondrion-specific ribosomal protein mL44 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722847.1">
        <property type="nucleotide sequence ID" value="XM_062869083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M2Y2"/>
    <dbReference type="GeneID" id="87887912"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19873">
        <property type="entry name" value="DSRM_MRPL3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000043">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044443">
        <property type="entry name" value="Ribosomal_mL44_DSRM_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044444">
        <property type="entry name" value="Ribosomal_mL44_DSRM_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207:SF32">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207">
        <property type="entry name" value="RIBONUCLEASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22892">
        <property type="entry name" value="DSRM_MRPL44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNase III" evidence="9">
        <location>
            <begin position="94"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="43"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3307067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="421" mass="46640" checksum="48D29323B2C18FE8" modified="2024-07-24" version="1">MKRLRLDRWTGQLLVARPGASSASTPRAALRSPAMCRCMTVRNQSTAASPQIPQEDDYYDGTDHSRFPPLEQLPPRATSLPSPPPERALQSAKLAALHARLSLPEKVPLQTLGRALVDASADDNPQYNNTNLAFVGHTLINYHVGEWLMCRYPRLPMEVLYAAMKGYAGPTALHHVARSWGVEHAAAPGGEVDPGLLQFSMHKPGEAVTVFGYKRAEYDGLRKHQWRHGISSRVVFDDDFGEIVQSEEEKDQMRARADTEYGNEYTRTLAEAAYATCARAVVGAIYAHTGREAAKAFIKAHILSRTLDLSRLFFFKKPTRELSLLCAREDFEPPVARLLSETGRMSRTPVFVVGIFSGKDKLGEAAAASLEHARAKAAMNALKSWYLYSPGEHVRVPSDMLSEDAQPWDPAYIDIGEIIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M351</accession>
    <name>A0AAJ0M351_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell morphogenesis N-terminal-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_528909</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722789.1">
        <property type="nucleotide sequence ID" value="XM_062869067.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87887896"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025614">
        <property type="entry name" value="Cell_morpho_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025481">
        <property type="entry name" value="Cell_Morphogen_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039867">
        <property type="entry name" value="Furry/Tao3/Mor2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029473">
        <property type="entry name" value="MOR2-PAG1_mid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295">
        <property type="entry name" value="FURRY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295:SF30">
        <property type="entry name" value="PROTEIN FURRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14225">
        <property type="entry name" value="MOR2-PAG1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14228">
        <property type="entry name" value="MOR2-PAG1_mid"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14222">
        <property type="entry name" value="MOR2-PAG1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cell morphogenesis protein N-terminal" evidence="2">
        <location>
            <begin position="365"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis central region" evidence="4">
        <location>
            <begin position="1005"/>
            <end position="1486"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis central region" evidence="4">
        <location>
            <begin position="1489"/>
            <end position="1723"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis central region" evidence="4">
        <location>
            <begin position="1793"/>
            <end position="1961"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis protein C-terminal" evidence="3">
        <location>
            <begin position="2010"/>
            <end position="2260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1151"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1200"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2475"/>
            <end position="2557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2580"/>
            <end position="2605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2620"/>
            <end position="2640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="163"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1202"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2475"/>
            <end position="2493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="2525"/>
            <end position="2540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2590"/>
            <end position="2605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3307009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="2640" mass="292788" checksum="6E4ED59BE0AFDA29" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M3D7</accession>
    <name>A0AAJ0M3D7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_510745</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723253.1">
        <property type="nucleotide sequence ID" value="XM_062867875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M3D7"/>
    <dbReference type="GeneID" id="87886704"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16861">
        <property type="entry name" value="GLYCOPROTEIN 38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16861:SF4">
        <property type="entry name" value="SH3 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G13610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042467820" description="WSC domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="4">
        <location>
            <begin position="37"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3307473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="356" mass="37544" checksum="725F1EEDC1F821CA" modified="2024-07-24" version="1">MPLQSTALLWASLSIAAAFKAGPTPMRRADDRLSGPSIPVEYCATVNTADMDPFNSIYQSEGRCYTNCTDLNFALAIVQEKNCWCSNLIPNSDDRTSLSDCRSPCPGYPTDYCGGDGVFGYTSRRGQSQGYGASGRLCHCLASQLLTITLSQTPSSASSSSTSDSSSSSTSSESSSTAASTTQSQSQSPVVQTVTIGGTVRTVTATAGITQPDADKDKSINGGAIAGIIIGILGGLCVAAGAIFFWLRRRREKQLNEKGMGSPVGRGGSPAMMTTTTTGEGSAAGGSAGLDSNKRRSYLMPIDPRLDPFATGIYTGDHNRSRESFNSLQDNHDYSRRVHDPPRVLRAINPDPADDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M3F7</accession>
    <name>A0AAJ0M3F7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">endo-polygalacturonase</fullName>
            <ecNumber evidence="3">3.2.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Pectinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B0T15DRAFT_185175</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(1,4-alpha-D-galacturonosyl)n+m + H2O = (1,4-alpha-D-galacturonosyl)n + (1,4-alpha-D-galacturonosyl)m.</text>
            <dbReference type="EC" id="3.2.1.15"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.15" evidence="3"/>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723431.1">
        <property type="nucleotide sequence ID" value="XM_062862362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M3F7"/>
    <dbReference type="GeneID" id="87881191"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000002">
        <property type="entry name" value="Endopolygalacturonase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050434">
        <property type="entry name" value="Glycosyl_hydrlase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884:SF1">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00502">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 15 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042463351" description="endo-polygalacturonase" evidence="16">
        <location>
            <begin position="17"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="active site" evidence="14">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00083621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK3307651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="360" mass="36946" checksum="8D4037F697C618BB" modified="2024-07-24" version="1">MIPSVLILSLGALAAANPLPAKRASCTFTDAASAISGKKSCSTITLKDITVPAKTILDLTKLNDGTKVIFSGKTSFGYEEWDGPLISVSGNNIHVEGAPGHVIDGNGAKWWDGKGSNGGKKKPKFFYAHSMKNSVIKGLNVKNTPVQAFSINGATNLEVYDVTLDNSAGDSQGGHNTDAFDVGSSTGVYISGAVVKNQDDCLAINSGTNITFTGGSCSGGHGLSIGSVGGRKDNTVKTVRILNSSISNSQNGVRIKTVYGAKGSVSDVEYSGITLSGITKYGIVIEQDYENGSPTGKPTSGVPITDLTVKGVTGSVKSSATDVYILCAKGACSNWKWSGVSVTGGKKSSKCSNVPSPAAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M3G9</accession>
    <name>A0AAJ0M3G9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_174528</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723134.1">
        <property type="nucleotide sequence ID" value="XM_062862238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M3G9"/>
    <dbReference type="GeneID" id="87881067"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3307354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="393" mass="42707" checksum="B334303410B00B26" modified="2024-07-24" version="1">MADSSPTNKPATGTGTPSKVGSPKSAGSPKSAKSPPKSPPKSPSEASEAAAGPSTDILPPETWTEIGSDAGDVDSALGDDDEGSTASLTASLLEYRTYHGRTYHSNVGNAQYWGSNDERAAEAMDINHHMLTLALGGKLFLAPLEKDKVKKAIDIGTGTGVWAIDFADAFPQTQVIGTDLSPIQPSWVPPNLSFEIDDATQPWTFRPNSVDYIHMRYLLGSIADWDALYREAYHTLAPGGWIEHYEAAPYLESDDGTVDENSAMGQWGKIFVAGSKVTGRSFTVVPDGVQRSGMEKAGFEDIQTWDFKCPIGGWPKDPQLREIGLYGRMALETDIEGYVLFITNVISGWSREQVLVYIAHLRRELRNNAIHGYCRLRVVWGRKPVKSTATANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M3Q9</accession>
    <name>A0AAJ0M3Q9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome biogenesis protein RLP24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_184973</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723419.1">
        <property type="nucleotide sequence ID" value="XM_062862360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M3Q9"/>
    <dbReference type="GeneID" id="87881189"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902626">
        <property type="term" value="P:assembly of large subunit precursor of preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.20:FF:000001">
        <property type="entry name" value="probable ribosome biogenesis protein RLP24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="entry name" value="Ribosomal protein L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056366">
        <property type="entry name" value="Ribosomal_eL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_eL24-rel_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792:SF8">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN RLP24-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="TRASH" evidence="5">
        <location>
            <begin position="6"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="187"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3307639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="221" mass="25773" checksum="762730B8BFD5F077" modified="2024-07-24" version="1">MRVDNCFFCGRPAWPSKGITFMRNDGKSFRFCRSKCHKNFKMKRNPRKLKWTKAYRKNAGKEMVVDSTLQFAARRNVPVRYDRELFAKTLKAMERISEIRARRERVFYKKRMAGKRARELAAARKLVAENEHLLPRLRGSEKRRLAELAAERGVDVEELEREELANARASKKSKAFGGEVRRLRVRTDGGVEEITESMGGRMEEDMDDDDDEDDDDGMDTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M3W4</accession>
    <name>A0AAJ0M3W4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Thiol-specific monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_95632</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FMO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723837.1">
        <property type="nucleotide sequence ID" value="XM_062871489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M3W4"/>
    <dbReference type="GeneID" id="87890318"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000138">
        <property type="entry name" value="Flavin-containing monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3308057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="467" mass="52288" checksum="374E40A3E05D7D0B" modified="2024-07-24" version="1">MGSQGVVRQFDVSNIAIIGAGPCGLAFAKYLLAQNAFKKIDIFEQQSEAGGVWNYSPRPSDTLQVPQVSADCPADPPLSVPGEEAPVFPSPMYELLHTNIPRALMRYSDLPIRQDSLIFPSRVHIQEYVVEYAKDIRHLIRFSTQVRDVRLRQVDGQDRWDLDALCLRTGKTTSATYDAVVVASGHYTAVHIPDARGIREFHQAHPGVILHSKQYRSPAPFANKKVVIVGNAASGLDIAAQISSVCKKPLLLSVQSPTPQANLEYAGAEEVPVIEEFLVVERGIRFQDGRVERDVDTVIFATGYLFAFPFLRSLKPPVVADGRRVHGLYQHLFHIDHPTLVFSRLPIKVVPFPLSESQAAVVARTWANLLPLPPAQEMRKWEEEEAQRQGAKFHVWPEGGDAAYINSVHDLITRSGTPGKEPPHWDPELVWQRQIYFQAKLKFELDGRRAHTLEELGFKYSPNVENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M450</accession>
    <name>A0AAJ0M450_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribonuclease T2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_104244</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the RNase T2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724063.1">
        <property type="nucleotide sequence ID" value="XM_062861403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M450"/>
    <dbReference type="GeneID" id="87880232"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033897">
        <property type="term" value="F:ribonuclease T2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.730.10">
        <property type="entry name" value="Ribonuclease T2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001568">
        <property type="entry name" value="RNase_T2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036430">
        <property type="entry name" value="RNase_T2-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240:SF22">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00445">
        <property type="entry name" value="Ribonuclease_T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55895">
        <property type="entry name" value="Ribonuclease Rh-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3308283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="300" mass="33265" checksum="0725B86FBEA13952" modified="2024-07-24" version="1">MAPSLRALVSYASSLVSRLPFFNSNDVRDVSPYEPLSAAPFCPFDGPMSCHNDTPVTGDSCCFVYPSGRMLLAQRWDQDIHVHGAEEDWTLRGLWADLCDGSKAHHCSLTPKYTNITAILRHYGQGELLEFMNRYWFAASGPNADLWTSEFNKHGTCINTLSPACYGPSHRPGIEVIDYFVRAAALFRMLDTYRALQQVGIVPDAGRQYALADVRKALERFSGGRVVLRCSSAAGDDEDVSQQAKGDDVLREVRYVFFITGSLQTGQFVPAQELGLGPDGNAGNCAPRVRYLPKRRMLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M4B5</accession>
    <name>A0AAJ0M4B5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_524697</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062868790.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87887619"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
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    <dbReference type="PANTHER" id="PTHR24171:SF10">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 29-LIKE"/>
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        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
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                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
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                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
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                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <proteinExistence type="predicted"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3310516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
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    <sequence length="79" mass="8768" checksum="1383BC2D4A38DC3B" modified="2024-07-24" version="1">MADNVPSGTEYRAGRKESVSSTTSTTSTTTAPPYRRSSHALFETLQAQKRKDDPVSIARRQSLNEQRPVGGVVAQFWNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
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                <person name="Ament-Velasquez S.L."/>
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                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
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                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_062864265.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SH3-like_dom_sf"/>
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        <property type="entry name" value="SH3_domain"/>
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    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
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        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="SH3"/>
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    <proteinExistence type="predicted"/>
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            <end position="365"/>
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    <feature type="region of interest" description="Disordered" evidence="3">
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    <feature type="region of interest" description="Disordered" evidence="3">
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    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="272"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="386"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="400"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3310444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="549" mass="58985" checksum="35F5E63C28850449" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M6C7</accession>
    <name>A0AAJ0M6C7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_518828</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726344.1">
        <property type="nucleotide sequence ID" value="XM_062868391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M6C7"/>
    <dbReference type="GeneID" id="87887220"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF2">
        <property type="entry name" value="PROLYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="73"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3310564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="475" mass="53258" checksum="138856B600202E41" modified="2024-07-24" version="1">MAAVQAARLLSRRAHVLPGRLHVTELFFEVPKNHAKPEDGTLKLFGRCVRKYSRPIVPPSKSELEVQEKLPYLVYLEGGPGFGNREAQNVSLTRTALERGYQVLYLDYRGTGLSTPVNADSVLAQGEPPEQAGYLKLFRADSIVRDLEAVRLCLTKDFDEGAKAWSIFGQSFGGFVALTYLSKYPQGLREAFLTGGLAPIRRTAEEVYTATYKKVIERNQAYYKKYPEDIANLRRLATYILSQPGGRIQLPAGGYLTVQLLLTIGLAFGGHGGLDDVHSLVLRLATDLDQFGFFTRASLAAFEAQIAFDTHPIYAILHEAIYCRNAKGAAPSNWAAYRVGRDLPQFSWLVDPRTACASTPESQPLYFSGEMVFPFHVTDSPELKRIAEAVEILAQTTEWGDDLYDEEQLRRNEVPVYAVSYIDDMYVDFEFARETAALVRGIKVLETNGWYHDAVRSKAEDVLTELFKLRDDEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GKL9</accession>
    <name>A0AAJ0GKL9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_320920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717454.1">
        <property type="nucleotide sequence ID" value="XM_062864047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GKL9"/>
    <dbReference type="GeneID" id="87882876"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3301674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="293" mass="32851" checksum="0DCA3745B737BB24" modified="2024-07-24" version="1">MPTYYTLPPTPSGSSLHSPMDSASSSASSSRSNSNSRSRVPRLQASNKEKGDSKTKKSIPYLFLGSVVGASLLAHKYWPRGFPHGDKEDWEISELGRRARQRRLAEKAARRGRGGGGATEDRGRSRSRSRSRSRSRGPNRRWLRSESRERSVECRECVVVSCCCRGRSCSRSRSRHRHRSRSVSRERTAVLAATERHYPATTGSSERYRLMDRSASISRSLSVSSTGSRYSLERSASSAAPRYLRLPAQGQYYDRDAHGSEHGYRESRAIARRLSLDAGGAERRDDGVVWRCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GKT4</accession>
    <name>A0AAJ0GKT4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HPP family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_405184</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062865284.1"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007065">
        <property type="entry name" value="HPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058581">
        <property type="entry name" value="TM_HPP"/>
    </dbReference>
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        <property type="entry name" value="TRANSMEMBRANE PROTEIN DDB_G0269096-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33741:SF5">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN DDB_G0269096-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TM_HPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
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        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
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        <location>
            <begin position="54"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
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            <begin position="267"/>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3301740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="337" mass="35931" checksum="0D61D6408BE47C33" modified="2024-07-24" version="1">MTATHHPRRGPSRWHFDIDKHLNPFFPPSALPYLPSPVAHFLGYRTHAPPPSLGNLAMIFWAVVGVFSSLAIIGAVAQEVPAFQSRAVPIIIGSFGAAAVLDFYAIESPLAQPRNAILGQLVSALVGIVICKLFALSPHFEAVRWLGASLACALATAAMALTGTVHPPAGATALMAVLDPSVSALGWFLFLPLLLGCALMLAVALLVNNIQRRFPYYWWSPGETGLFWEQRRGGRIETEPCEKREKVGGGGVGVGERKKGRDEGEESSGSTSTTSGSTAGGDVESNMGSTGQLARTVSVMSGRGPEIVIRRGVVKIPESLSLRPEEILSLEMLSERL</sequence>
</entry>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717542.1">
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <end position="59"/>
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        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3301762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="470" mass="52922" checksum="5F0DDD544009EA24" modified="2024-07-24" version="1">MSRFSRHHHDFSYGYGGASNPWDTRTVFIGVDNDDDEDNDEADRYSRVTLGGRSRRPSASVSVIGYGDLEFRPRPRAARDRDSRDTDRNRVRVRHRDGSYRANPLKPSLSTGLVDYETETLKQRLRLSDRSPPPAPPPPPPAPGTYARQHNHRDSHHHHHHHPRARSLSLSRLSAGDSDEESDRLVAHAHGGGWDSATVVPDPPGGYYRHPRLSLSSPRVGLAGAGWPLVSSRPGTRSPSLERERERERERYERGYQVVPVVPPYGNEDDLRLRLGGVGSPRVPARKGRSESFERYDGTLMNGRDGGSPGTGGRVRAASKYRGVRPQYNQVHALILTWSFHDLRTEDYTAPPSSDYVSLEEETARLRDTFESYGYTVHEFLIPMHRSVESLKAKLKQFCRYAADDTLLIIYYHGHGALDDDNELVFSSHDHPDNPGWSQAAAAELYAALLSGDACATHGRRERYQELLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ0GLH8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062863744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GLH8"/>
    <dbReference type="GeneID" id="87882573"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3302144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="225" mass="25543" checksum="0ADC5652067DACEA" modified="2024-07-24" version="1">MRHRYTACGSQQRIGLNWCRRYRPRGSKRRWSLCALGCSSRRRRLNTLIKQDHHYYGRTAGVGRRGRGCLMRRESRRGRGAQLPLTSSGRTDEQNAKASQQADRSATRLPGSATQICYPDRKCGIIMGLLRHSHGLTMWSAARPCGCSVWRRQPGTLLRRLSQWQLCGDMIFAALRTGATLSKRSVAQFHCRPGTLRVPIRVVLRLIARTPEAGSYRRARGVLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GLJ1</accession>
    <name>A0AAJ0GLJ1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_294638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717934.1">
        <property type="nucleotide sequence ID" value="XM_062863746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GLJ1"/>
    <dbReference type="GeneID" id="87882575"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042599538" evidence="1">
        <location>
            <begin position="17"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3302154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="147" mass="13783" checksum="DE5EA03BD4BF2957" modified="2024-07-24" version="1">MRCVALLAAFAALASAQDTTTPVTTANSASSTSSSTDLSSAISSVISSIESQGSSLVSSVTSDAGSVLSSLSSVAATATGSAAASLSSEIASISSSIESVISSSINPSISSAIESASTATSIGGAPMQTAAVAVGALFGGAAVLANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GLK2</accession>
    <name>A0AAJ0GLK2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_487367</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717917.1">
        <property type="nucleotide sequence ID" value="XM_062866429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GLK2"/>
    <dbReference type="GeneID" id="87885258"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032862">
        <property type="entry name" value="ALKBH6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46030">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46030:SF1">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="8">
        <location>
            <begin position="118"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3302137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="259" mass="29460" checksum="CA108EA2D3739116" modified="2024-07-24" version="1">MSHHQNILGLRERLLEVSLLLFDLSNRRSPPAAYYIANFLTEEEEQTILHKVETAPKARWRQLTHRRLQTWPSDLVKDTLLDAAPLPDWLENPVVSRILSIPLSDDEPNIFAGSPHLRPNHVLINEYPPNTGIMPHKDGAAYYPVVCTVSLGSSLCLNLHKNKEDGALDPEPVWRILQEPRSLLITTAALYSEYLHGIEPISADIDLSERTIANWHLLRSPSLYTDGVNQRETRTSLTYRDVLKVSRLGTKLGPLFKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GMA8</accession>
    <name>A0AAJ0GMA8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Abnormal eversion of vulva protein 20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B0T15DRAFT_487644</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">GTP-binding protein that functions in embryogenesis, cytokinesis, germline development and microtubulule cytoskeleton dynamics.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718343.1">
        <property type="nucleotide sequence ID" value="XM_062866452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GMA8"/>
    <dbReference type="GeneID" id="87885281"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04154">
        <property type="entry name" value="Arl2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000981">
        <property type="entry name" value="ADP-ribosylation factor-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045873">
        <property type="entry name" value="Arl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044612">
        <property type="entry name" value="ARL2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45697">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="9 15 17" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0519">Myristate</keyword>
    <keyword evidence="8 15 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="21"/>
            <end position="28"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="123"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00055307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00077919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK3302563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="181" mass="20653" checksum="0E9E44DFECBFF499" modified="2024-07-24" version="1">MLSILRKARLKDKELRILMLGLDNAGKTTIVKKIMGEDINTVSPTLGFIIKTIDYEGYKLNIWDVGGQKTLRSYWRNYFEKTDALIWVVDATDRLRIDDCRDELHGLLQEERLSGASLLVFANKTDVRGCMTGDELSEALRLGEIRTHRWNILQCSAMTGGNLKEGLAWVVEDAKARLFLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GMF9</accession>
    <name>A0AAJ0GMF9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_562606</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718434.1">
        <property type="nucleotide sequence ID" value="XM_062870585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GMF9"/>
    <dbReference type="GeneID" id="87889414"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="595"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="619"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="693"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="464"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="513"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="626"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="698"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="717"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3302654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="737" mass="79051" checksum="812899C584057DFE" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GMG9</accession>
    <name>A0AAJ0GMG9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0T15DRAFT_543627</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 13">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718459.1">
        <property type="nucleotide sequence ID" value="XM_062870009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GMG9"/>
    <dbReference type="GeneID" id="87888838"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001193">
        <property type="term" value="P:maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
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        <property type="entry name" value="Zn_ribbon_TFIIS"/>
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        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc beta-ribbon"/>
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    </dbReference>
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        <property type="entry name" value="ZF_TFIIS_1"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3 9 13" id="KW-0240">DNA-directed RNA polymerase</keyword>
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    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="14">
        <location>
            <begin position="88"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="11">
        <location>
            <begin position="24"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
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    <feature type="binding site" evidence="10">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
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    <feature type="binding site" evidence="10">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
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    <feature type="binding site" evidence="10">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
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    <feature type="binding site" evidence="10">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
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    <feature type="binding site" evidence="10">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
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    <feature type="binding site" evidence="10">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
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        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
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        <source>
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        </source>
    </evidence>
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        </source>
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        <source>
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        </source>
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        <source>
            <dbReference type="EMBL" id="KAK3302679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="128" mass="14266" checksum="CF82FB006D409F62" modified="2024-07-24" version="1">MSSPTNPTSGNRKKPAEQITFRFCSECSNMLYPKEDEVERKLMFTCRTCSFSEEATSSCIFRNAMNNAAGETAGVTQDVGSDPTLPRANRTCPACKHEEAVFFQSQQRSAETGMKLFYVCCECGNIFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GMY5</accession>
    <name>A0AAJ0GMY5_9PEZI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name evidence="1" type="ORF">B0T15DRAFT_495531</name>
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    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Chaetomium</taxon>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
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    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ0GMZ2_9PEZI</name>
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            <fullName evidence="1">NACHT-NTPase and P-loop NTPases N-terminal domain-containing protein</fullName>
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    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_402363</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
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            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
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                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0AAJ0GMZ2"/>
    <dbReference type="GeneID" id="87883986"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031352">
        <property type="entry name" value="SesA"/>
    </dbReference>
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        <property type="entry name" value="SesA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NACHT-NTPase and P-loop NTPases N-terminal" evidence="1">
        <location>
            <begin position="10"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3302953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="219" mass="23174" checksum="1FA51F653FB8B8C7" modified="2024-07-24" version="1">MSGAELIGIISGIVSLAQASIKIYQAVDNASGLPKSFQDVFARLPLVQSTLEAAAAGIAEEEEAGDNLASDRSRAALGKVLESCRDKAAALNKILRAVMPTAGAKRMERYLKAIKTTPNADKVENLMDGILRDMQVLTVSQVVNAPIRSQMKELIAAIERMEVERTDDGSCAPAVSLYSAGSGSQYVHSGRGDQNVVAGHGVQITGKSTGPFYFGRTYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GNP0</accession>
    <name>A0AAJ0GNP0_9PEZI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_513522</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719108.1">
        <property type="nucleotide sequence ID" value="XM_062868044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GNP0"/>
    <dbReference type="GeneID" id="87886873"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3303328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="132" mass="14860" checksum="F26535D2AAB399BF" modified="2024-07-24" version="1">MGTEYTPYGYCCRHHLGFRAFFNRWPLCVLAAATKRRMSMLLLNGNPWPRFSQYLQQNTGSRPLSLSQATKGRTSTQVGDHWGILGVRREPIPRRYDGSGVVNVVLANDFYIFHEISACKANVAASAKHIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GPG6</accession>
    <name>A0AAJ0GPG6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_541067</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719507.1">
        <property type="nucleotide sequence ID" value="XM_062869830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GPG6"/>
    <dbReference type="GeneID" id="87888659"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF18">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="104"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="490"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="612"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="131"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="383"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="622"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3303727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="732" mass="79623" checksum="AD7D75A6C15B0476" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GPP1</accession>
    <name>A0AAJ0GPP1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_487156</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719633.1">
        <property type="nucleotide sequence ID" value="XM_062866416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GPP1"/>
    <dbReference type="GeneID" id="87885245"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF21">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3303853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="446" mass="49262" checksum="E1B06419FB15E4EF" modified="2024-07-24" version="1">MTRRINLKTDLALLPMLSLLYLLNGLDRGNIGNAQTQGFTDDIGAQPRDLNFAVPLFFITFVLFQPLSATVDWWLGPRHWIPIMELQGDPEQISWGVVTATQAVIQGRAALITTRLPIGVLEAGFYPTVVMYLDLGLFYSQYAIANAFSGALSYGNFLIHHPRLKPWQLLFVIEGSATCCLAVISWFWLPAGPGTAWFLTKQERAFASDRVRSGSPDDGVSPKLTRRDVVETAKDGKLWFALRLSVFLPLVVRGMGYRTLEANLTSVPPAVCSALGLYLFAFSSDRRQERGYHIMAAIVVSLARLVAVVTAPTSAGRYAALCIFLFGGYVPPLLTVAWHSGNTPAAGKRALVLGANGWGNLAGVIGSQLYRPEYAPEYRKPFLVTLGFVATALVGFLAYWAALQTVNRRRAAVMNSKTPEEIEMERANDQRYADRNRQRGVETRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GPS1</accession>
    <name>A0AAJ0GPS1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Suppressor of anucleate metulae protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_485695</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3303898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719678.1">
        <property type="nucleotide sequence ID" value="XM_062866304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GPS1"/>
    <dbReference type="GeneID" id="87885133"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053185">
        <property type="entry name" value="SET_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332:SF2">
        <property type="entry name" value="SET-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="5">
        <location>
            <begin position="3"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="478"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3303898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="552" mass="62161" checksum="F78BFFDCB7250979" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQ42</accession>
    <name>A0AAJ0GQ42_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_286058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719630.1">
        <property type="nucleotide sequence ID" value="XM_062863636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQ42"/>
    <dbReference type="GeneID" id="87882465"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3303850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="494" mass="58656" checksum="CF1F41350DCEBD9C" modified="2024-07-24" version="1">MDPYLQLPPELLQLIVRQLDPVSLIALSQTSRAWRALISPIHHDFVQRLLVLELQPKHGGIVPLFTERDDAFSFTPPWTIERWKTINYACCGCMKLRGHMMFDNRAILGRRYRKPPPGSVEARKATLTDWEPLNHGARWRLIQKRAGEEEQRRQNWRDVARRIYKPHGPPPHPFAQQPPIHDVAYYRVLERLFAGTSRQNRRCIECRYQRGDWRKQPVFGGQILRGNAKCPVVVSRQFPFPSLWERHFPGLPLPGPMPAPKAPRRWRVLREWVDSGNDYYTLYAVRCPSCGKWQESSAFRQWTLWHRRFPDMGQPVHCLRLLCNHCHLNTYKDKGLLAKELNDGAILTINKERREMFSCLTRGWRLIHNDFYHPKGALSDLKYQAVRGEIFDGVTLADCRVEVDMTSFDVTDLRLYRLRFDRLREFINHELDLKTRAEILQSWLRVWFEEYELIEDMYCWLNYQEIAISSNPYYVFNYVMEKAPYYIDTIYGNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQD1</accession>
    <name>A0AAJ0GQD1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_231458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719926.1">
        <property type="nucleotide sequence ID" value="XM_062862951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQD1"/>
    <dbReference type="GeneID" id="87881780"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3304146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="107" mass="11914" checksum="A16835F491F05F47" modified="2024-07-24" version="1">MAFEWLALFIFSLSVCYSVLIAGSYCCILPLVYVLDLLYCPRGAGLSRWLFLFVFRGLNAQVLLRGECTYSILIEQETNMLSPSARSGYLHQPAHNSLAAHSSECTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQE7</accession>
    <name>A0AAJ0GQE7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Triose-phosphate transporter family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_233692</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720018.1">
        <property type="nucleotide sequence ID" value="XM_062862981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQE7"/>
    <dbReference type="GeneID" id="87881810"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="10">
        <location>
            <begin position="42"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3304238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="400" mass="44131" checksum="F6E149C8D18FC562" modified="2024-07-24" version="1">MGVEEKSRASGDQPRDQNGPVLPTVNPEAEKSQPPKPSLHPAFYVSVWIALSSSVILFNKWILSTLNFSYPVLLTTYHLTFATIMTQLLARYTTLLDGRKTVKMTGRVYLRAIVPIGFFFSLSLICGNLTYLYLSVAFIQMLKATTPVAVLISSWALGVSQPNLKVFLNVSAIVIGVIIASFGEIKFVWIGFIYQIAGIIFEALRLTMVQRLLSSAEFKMDPLVSLYYFAPVCAAMNFVIALLWEVPKVSMAEIYDVGLFTFFLNGLCAFLLNVSVVFLIGKTSSLVLTLCGVLKDVLLVVASMIIWGTQVTALQFFGYSIALGGMIYYKLGYDAIKGYAGEASRQWADFGNRRPILRRLAVILLALMTVFVLLGGLAPADIDATQYLNEAKEKIGITKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQG3</accession>
    <name>A0AAJ0GQG3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Endonuclease/exonuclease/phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0T15DRAFT_494742</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">PML body</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720048.1">
        <property type="nucleotide sequence ID" value="XM_062867037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQG3"/>
    <dbReference type="GeneID" id="87885866"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070260">
        <property type="term" value="F:5'-tyrosyl-DNA phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09080">
        <property type="entry name" value="TDP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051547">
        <property type="entry name" value="TDP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15822">
        <property type="entry name" value="TRAF AND TNF RECEPTOR-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15822:SF4">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="12" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="11">
        <location>
            <begin position="5"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3304268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="271" mass="30260" checksum="039671A65F115544" modified="2024-07-24" version="1">MRPEDEARMASALKHLRSLVSRQADPSVIMLNEMTEGDLTLIKQADWVRQDYNITDASTVHWASPAYGTTMLVHRSLPIKSVFRVHYERTGMQRDALCVDIALPQGQTLRVATSHLESLKRDPPLRPSQLATAAKYLHEDGVYAGIIGGDFNAIEDFDRTLHVGNNLNDAYLESGGVEDAEEGMTWGQMAGRSQRQRFGLSRMDKIMFCGRVELVGFERFGMGVQVEDEGAAQQLLEGTDLERPWVTDHLGVKAQFRIESPETVGENRAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQN0</accession>
    <name>A0AAJ0GQN0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Urease accessory protein ureG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_235561</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720081.1">
        <property type="nucleotide sequence ID" value="XM_062863011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQN0"/>
    <dbReference type="GeneID" id="87881840"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05540">
        <property type="entry name" value="UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000208">
        <property type="entry name" value="Urease accessory protein UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01389">
        <property type="entry name" value="UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004400">
        <property type="entry name" value="UreG"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00101">
        <property type="entry name" value="ureG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31715">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31715:SF0">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW/HypB/UreG nucleotide-binding" evidence="7">
        <location>
            <begin position="60"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3304301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="279" mass="29622" checksum="A8595F6DCAE3F0D4" modified="2024-07-24" version="1">MSGVTHSHDGVHSHSHAHSHDTFNAAEHGHSHEILDGPGSYVGREMPLTEGRNWNDRAFTVGIGGPVGSGKTALMLALSRALRKSYSVAAVTNDIFTREDAEFLTAHRALPASRIRAIETGGCPHAAVREDISANLAALEDLHRQFDTDILLIESGGDNLAANYSRELADYIIYVIDVSGGDKVPRKGGPGITQSDLLVVNKTDLAEAVGADLGVMERDARKMREGGPTVFAQVKKGVAVDHIVNLILSAWRASGAEEARKAVGGPRPTAGLEELGEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GR08</accession>
    <name>A0AAJ0GR08_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_235192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062863006.1"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3304290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="384" mass="41130" checksum="6E94E6D128130C40" modified="2024-07-24" version="1">MSSTSPSDPPKRPRLSLQIKAAANCSTGRTSRCIAAAVDVKSPTAFNTLSNVYATAVDRSTPVQENPPTAILGRRPMLRLQTQGVTGKDRNTPTPYRGPYLDTPITAQPMSPAVAQQICFPSAAMTATPPLSAQPPDQTGTQVFTFDGATPATAVSEAPRAPAPAAQHPKRRTSMPTGTTKLPYTHPRSLRSILRNSPLPPLSTRSPESPRRQSLRLQEKAARRVAYNSPLTQEITTSKYTKSHIDLLAEDATPISPSTSSSDDGDSSLDLAMADAASDNTRDGGQTPGPFEEMRRRMANMQASTPMALSPTGGGIRKRGGKRREKKRRWVWTIGQDEEGEESESAATRTSGAAEPVKTEPSMSVPVLAVPAPRPRTARTLSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GRH5</accession>
    <name>A0AAJ0GRH5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_512906</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720579.1">
        <property type="nucleotide sequence ID" value="XM_062868010.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87886839"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02249">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="993"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="1029"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="1134"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="1168"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="1201"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
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        </location>
    </feature>
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        <location>
            <begin position="1409"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="9">
        <location>
            <begin position="1531"/>
            <end position="1573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1581"/>
            <end position="1625"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="33"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1601"/>
            <end position="1610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3304799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1625" mass="179871" checksum="1CFF8A4E876C7CA8" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GRJ8</accession>
    <name>A0AAJ0GRJ8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7514 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_247815</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720370.1">
        <property type="nucleotide sequence ID" value="XM_062863134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GRJ8"/>
    <dbReference type="GeneID" id="87881963"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055936">
        <property type="entry name" value="DUF7514"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39611:SF1">
        <property type="entry name" value="HYDROXYPROLINE-RICH GLYCOPROTEIN DZ-HRGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39611">
        <property type="entry name" value="HYDROXYPROLINE-RICH GLYCOPROTEIN DZ-HRGP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24355">
        <property type="entry name" value="DUF7514"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7514" evidence="2">
        <location>
            <begin position="213"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="390"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3304590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="660" mass="73791" checksum="806D78619133D151" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GRN5</accession>
    <name>A0AAJ0GRN5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MutL C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_568435</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720455.1">
        <property type="nucleotide sequence ID" value="XM_062870764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GRN5"/>
    <dbReference type="GeneID" id="87889593"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032300">
        <property type="term" value="C:mismatch repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="entry name" value="MutL, C-terminal domain, dimerisation subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="entry name" value="MutL, C-terminal domain, regulatory subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF47">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="DNA mismatch repair protein MutL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MutL C-terminal dimerisation" evidence="3">
        <location>
            <begin position="681"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="406"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="427"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="445"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="474"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="492"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3304675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="951" mass="104581" checksum="F3FB595663C31830" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GS99</accession>
    <name>A0AAJ0GS99_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Short chain dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_531575</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720969.1">
        <property type="nucleotide sequence ID" value="XM_062869258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GS99"/>
    <dbReference type="GeneID" id="87888087"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051122">
        <property type="entry name" value="SDR_DHRS6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057571">
        <property type="entry name" value="SDR_PhqE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43477">
        <property type="entry name" value="DIHYDROANTICAPSIN 7-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43477:SF1">
        <property type="entry name" value="DIHYDROANTICAPSIN 7-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23441">
        <property type="entry name" value="SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3305189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="266" mass="28667" checksum="C6F76B6FFD6D57A5" modified="2024-07-24" version="1">MSDQKKYANKLHGARVLVIGGSSGIGFCTAEACVEYGALVTVASSNPAKVEAAVARLQASYPSAKANVHGLTVDLSKPDTLESELQSLFERAAQAMGGSELLDHVVFTAGDALATMKLADMTMEAILQAGQIRFFAPLLAAKFIPRYVRPSRESSYTITTGSISERPMPDWSVIGSFAGGHHSMVRNLALDLRPIRVNGVSPGPVDTELWRVPKEEKDRLMEQYGKRMATGRTGRPEDVAESYVACIRDYNMDGAIIRTDGGGLLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GSC1</accession>
    <name>A0AAJ0GSC1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_397993</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721038.1">
        <property type="nucleotide sequence ID" value="XM_062864933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GSC1"/>
    <dbReference type="GeneID" id="87883762"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="141"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3305258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="264" mass="28945" checksum="3A88504E027326C5" modified="2024-07-24" version="1">MSGLPAPSSSYQNPVCPSLGAGSSQTSEPSLPWIGSPVFADSPMSHDGPNMPNEGLVNPFEGFDFKAMLDACSGDLDLSTVDLAPDHAMSMETFNNCLDTEMLASFDWGLGSDFLDPFGTPSLVGSESPVDSVLDFTSGTSSPLERFSPAPFPTAGTSPASRSPATSAPRQVHRCAETSCTKVFSRRSDLKKHERSTHRQPFRCHLQGCGKGHADQRALHRHFWTRHREYAELHNIPSERAKCPHCDYEGRGDNLKRHMKKHMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GSS8</accession>
    <name>A0AAJ0GSS8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_484923</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721040.1">
        <property type="nucleotide sequence ID" value="XM_062866256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GSS8"/>
    <dbReference type="GeneID" id="87885085"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030798">
        <property type="term" value="F:trans-aconitate 2-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.290">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023149">
        <property type="entry name" value="Trans_acon_MeTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861:SF1">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="3">
        <location>
            <begin position="46"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3305260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="280" mass="32141" checksum="602962F826D67E41" modified="2024-07-24" version="1">MSKSTGSETRGSDWSPDQYLLFADARNRPIHDLIAFLSPEYSPSSIIDLGCGPGNSTELLAKRFPNAKISGVDSSPAMLARARTALPNIDFTQADLRWYEPPPGVDLLFSNAVFHWLRQDERIFHITRLLRTLKPGGILALQMPDNYHEGSHRAMRDMMKTSSLALHFKDLPREERPWIDETEEPIEYYNALMPHCRAVETWTTRYVHVLDAYEDIVEWVKGTGLQPYLNLLPDERLRDTFLKEYKARLRREYARAQDGKVLLAYPRRFVVAYSAGGAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GT23</accession>
    <name>A0AAJ0GT23_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_434222</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721190.1">
        <property type="nucleotide sequence ID" value="XM_062865794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GT23"/>
    <dbReference type="GeneID" id="87884623"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503">
        <property type="entry name" value="MCG48959-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503:SF2">
        <property type="entry name" value="NEGATIVE REGULATOR OF SPORULATION MDS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="54"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="176"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="782"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="960"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="221"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="782"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="960"/>
            <end position="982"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3305410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1057" mass="112391" checksum="50F44B2C4B6EB552" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GT54</accession>
    <name>A0AAJ0GT54_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycoside hydrolase family 79 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_398322</name>
    </gene>
    <organism evidence="8 9">
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721444.1">
        <property type="nucleotide sequence ID" value="XM_062864946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GT54"/>
    <dbReference type="GeneID" id="87883775"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052974">
        <property type="entry name" value="GH79_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031728">
        <property type="entry name" value="GlcAase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183:SF3">
        <property type="entry name" value="BETA-GLUCURONIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16862">
        <property type="entry name" value="Glyco_hydro_79C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042501275" evidence="5">
        <location>
            <begin position="21"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="6">
        <location>
            <begin position="156"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-glucuronidase C-terminal" evidence="7">
        <location>
            <begin position="376"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3305664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GT62</accession>
    <name>A0AAJ0GT62_9PEZI</name>
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        <submittedName>
            <fullName evidence="8">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_198375</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721250.1">
        <property type="nucleotide sequence ID" value="XM_062862545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GT62"/>
    <dbReference type="GeneID" id="87881374"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF35">
        <property type="entry name" value="ACID TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="439"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="469"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="531"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="559"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="7">
        <location>
            <begin position="74"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="28"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3305470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="634" mass="70474" checksum="0C6AA0F9C4092F2E" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GTC3</accession>
    <name>A0AAJ0GTC3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_208650</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XFP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721536.1">
        <property type="nucleotide sequence ID" value="XM_062862644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GTC3"/>
    <dbReference type="GeneID" id="87881473"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02011">
        <property type="entry name" value="TPP_PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01403">
        <property type="entry name" value="Phosphoketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023962">
        <property type="entry name" value="Phosphoketolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005593">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018969">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019790">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018970">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019789">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_ThDP_BS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003617">
        <property type="entry name" value="PRK05261.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003619">
        <property type="entry name" value="PRK05261.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31273">
        <property type="entry name" value="PHOSPHOKETOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31273:SF0">
        <property type="entry name" value="PHOSPHOKETOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03894">
        <property type="entry name" value="XFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09363">
        <property type="entry name" value="XFP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09364">
        <property type="entry name" value="XFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017245">
        <property type="entry name" value="Phosphoketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60002">
        <property type="entry name" value="PHOSPHOKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60003">
        <property type="entry name" value="PHOSPHOKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal" evidence="6">
        <location>
            <begin position="26"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal" evidence="5">
        <location>
            <begin position="603"/>
            <end position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3305756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="819" mass="92172" checksum="D02AEC2636ABAAC3" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GTR8</accession>
    <name>A0AAJ0GTR8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Galactose mutarotase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_216146</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldose epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3306013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721793.1">
        <property type="nucleotide sequence ID" value="XM_062862740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GTR8"/>
    <dbReference type="GeneID" id="87881569"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09019">
        <property type="entry name" value="galactose_mutarotase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.10:FF:000015">
        <property type="entry name" value="Aldose 1-epimerase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018052">
        <property type="entry name" value="Ald1_epimerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047215">
        <property type="entry name" value="Galactose_mutarotase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091">
        <property type="entry name" value="ALDOSE-1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091:SF0">
        <property type="entry name" value="GALACTOSE MUTAROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00545">
        <property type="entry name" value="ALDOSE_1_EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3306013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="341" mass="36817" checksum="FBA03335832E9C2F" modified="2024-07-24" version="1">MADAPVSFLPLGAIIQELRVGGVNIVQGFPEQSQYQRYNDPYFGETIGRVANRIKGARLENLNGGKVYPLAANNGPNNLHGGVVGWGKKIWNGPTPVGVRQIPGIEGLEGGESVKFTLTSEDGDEGFPGTVEVRVVYTVGKQVQGGKEVIVLGMEYEAELVGGVDETVINMTNHSYFNLTGGPSIEGTVVTLATNSYLPVDDGGIPTDGPKPFSKVDANKAFTLGAQEPDIDDCFIVNEAADAVPIDTRSLPLTKLVSAHHPESNIHLEVLSTEPAFQFYTGKYINVPEVAGVAARKARSGFCVEPSRYVNACNVDEWKSQMLLKKGEKYGCRIVYRAWKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GUA6</accession>
    <name>A0AAJ0GUA6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_136860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722078.1">
        <property type="nucleotide sequence ID" value="XM_062861825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GUA6"/>
    <dbReference type="GeneID" id="87880654"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3306298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="87" mass="9536" checksum="4D818323DA7AFC31" modified="2024-07-24" version="1">MAARNRHLETAGWGSKPQRLPLCDPSAVWVFASVTLSFAGVPDFLLAATFLNNGYRRSASGTGIITIQLWWAAHVFGLVNCLIYRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GUA7</accession>
    <name>A0AAJ0GUA7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_136264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722056.1">
        <property type="nucleotide sequence ID" value="XM_062861814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GUA7"/>
    <dbReference type="GeneID" id="87880643"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3306276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="212" mass="22999" checksum="31091B75804CC3A8" modified="2024-07-24" version="1">MLGSLMTTCQRGIVSAPSAFAPCSRRRRPKGARAFPRNMPTQNTRTRFLGCAHPSMIGRSRRKTSRASLSTCSSGIGSIGSLDISSPWAGEAERAEWSPDPVASICRQYFRAEEAARRQEFLNSHAADMAMTLTAGLRVRRLPEPVVESLSDTASEAGEGRAGPSSAAKAADAAMQANPERPVDVPATAKITTRNPLGFYLPREFRWTYHMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GW17</accession>
    <name>A0AAJ0GW17_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_166039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722914.1">
        <property type="nucleotide sequence ID" value="XM_062862163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GW17"/>
    <dbReference type="GeneID" id="87880992"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007146">
        <property type="entry name" value="Sas10/Utp3/C1D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237:SF9">
        <property type="entry name" value="NEUROGUIDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04000">
        <property type="entry name" value="Sas10_Utp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3307134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="376" mass="41233" checksum="A3E30E5BAF3C904C" modified="2024-07-24" version="1">MAAPATLLALLDSLTKSLTSTLEVAPKLANLELPKEGISLLDVKNELLLTYLQNLVFLILIKLRQAKKGVSGDKTENGSLGDVVVSKLVELRLYLEKGARPLEDKLRFQIDKVLRAADDAERNAKAAEEASTANGHGSGFESESGSEDDEEGDEDEREEAVDGRKIADLQHRPNLAGFQRPTAAAQAGKEKDASGVYRPPRIAPVVMPTTERREKAKERPLKSATLDEFIADEMSTAPIAEHSIGTTIVNGGRKIKTASERRREEELRNYEETNFVRLPKESKKDKAKRSKLEGRSARMSFGGEEWRELSGSVDRISRLTKGKSSGGGTKALLEKSRKRGIDTVDGPRGNGANMGERYQKRLKVLESGRGSRGKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GWG3</accession>
    <name>A0AAJ0GWG3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 18">Galactose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="5 18">2.7.7.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">B0T15DRAFT_510642</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:13989"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="2.7.7.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="17">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="16">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 18">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.12" evidence="5 18"/>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723139.1">
        <property type="nucleotide sequence ID" value="XM_062867868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GWG3"/>
    <dbReference type="GeneID" id="87886697"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008108">
        <property type="term" value="F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00608">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000001">
        <property type="entry name" value="Galactose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000009">
        <property type="entry name" value="Galactose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001937">
        <property type="entry name" value="GalP_UDPtransf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019779">
        <property type="entry name" value="GalP_UDPtransf1_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005850">
        <property type="entry name" value="GalP_Utransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005849">
        <property type="entry name" value="GalP_Utransf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00209">
        <property type="entry name" value="galT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943">
        <property type="entry name" value="GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943:SF1">
        <property type="entry name" value="GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02744">
        <property type="entry name" value="GalP_UDP_tr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01087">
        <property type="entry name" value="GalP_UDP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000808">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00117">
        <property type="entry name" value="GAL_P_UDP_TRANSF_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 18" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="12 18" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="11 17" id="KW-0408">Iron</keyword>
    <keyword evidence="9 16 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 18 21" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 16" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Galactose-1-phosphate uridyl transferase N-terminal" evidence="19">
        <location>
            <begin position="7"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Galactose-1-phosphate uridyl transferase C-terminal" evidence="20">
        <location>
            <begin position="220"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-UMP-histidine intermediate" evidence="14">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="28"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <begin position="77"/>
            <end position="78"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <begin position="194"/>
            <end position="196"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="356"/>
            <end position="357"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="361"/>
            <end position="362"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001107"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010951"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012384"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">Uncharacterized protein</fullName>
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    <organism evidence="2 3">
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723392.1">
        <property type="nucleotide sequence ID" value="XM_062870952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GWU7"/>
    <dbReference type="GeneID" id="87889781"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="196"/>
            <end position="213"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3307612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="400" mass="44344" checksum="69F031B350DC79EF" modified="2024-07-24" version="1">MPDHITGHTYSSFASPLDSPEPTSIVLQLAGILPLTALIEFINVPTKLHVFELAGCVPLWNWPMTPARARLLLATLDNAHACCLDREERCTALHCVDGRYGDCYPSSTPTRLAVASQSTQAVRVANTCPNMRERSIRRQTLNLVLLERAGGVPSTSVPFGSLRRSKSWTRFRSRALACGGWLALASTLVLRLASGLYVAAAYLLLLPLTGLAVRATHGGGGRRLVDDGVSGRTEYQPLVLCTSSWNGTHWWAFMGPSPIVNSLLNKPLFRTGASPGRTQRLWSAVLQVLIAGQWAVALLSCAQQDWNAIVISIWLAFCAIASSFLIKPHDCVRDWLHTLERRTSWINPILAHCEERREWESALLEYIENGVPTDQEATKKYWWKFITEGVESRYPETLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GX89</accession>
    <name>A0AAJ0GX89_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_522651</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPA43 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3307809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723589.1">
        <property type="nucleotide sequence ID" value="XM_062868642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GX89"/>
    <dbReference type="GeneID" id="87887471"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055029">
        <property type="term" value="C:nuclear DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04328">
        <property type="entry name" value="RNAP_I_Rpa43_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041901">
        <property type="entry name" value="RNAP_I_Rpa43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041178">
        <property type="entry name" value="RPA43_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF5">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17875">
        <property type="entry name" value="RPA43_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb7-like N-terminal" evidence="9">
        <location>
            <begin position="300"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="RPA43 OB" evidence="10">
        <location>
            <begin position="388"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="38"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="434"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="529"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="553"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="95"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="129"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="219"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU369086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3307809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="584" mass="64954" checksum="AB72C3901696D551" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GXB6</accession>
    <name>A0AAJ0GXB6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_522714</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3307827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723607.1">
        <property type="nucleotide sequence ID" value="XM_062868646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GXB6"/>
    <dbReference type="GeneID" id="87887475"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3307827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="293" mass="33311" checksum="E6B5E6147CFF9245" modified="2024-07-24" version="1">MATPTGHKGLIDLPVDALVQAAPNLHCLCLGSTEYDASRLSFPTAPLINLRRLFFDVSCNLHSTLLTEIVSNAPKLEFLALHWAGFTRMYEMRFHSGEAVVRCTTGVWDVIQTCRDSLRELRVHISDYIKSKVPEERDSPRDFRRLEVLKLNDHALSALYDAWKKKNRYTGEPDSFLSSILPPMIREVTFWDLKGLAMRAAMQSFARVAAFGPFRYLEKVTVAPSEAKYGPNSPWYNWRTWADVEAELEENFTKAGASFELVKSDQVIIWGWDFRLDPVLYLARSGLSLSGCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GXD5</accession>
    <name>A0AAJ0GXD5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rhodanese-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_86845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3307857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723637.1">
        <property type="nucleotide sequence ID" value="XM_062871404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GXD5"/>
    <dbReference type="GeneID" id="87890233"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01443">
        <property type="entry name" value="Cdc25_Acr2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828:SF50">
        <property type="entry name" value="REDUCTASE (ARC2), PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13400)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="44"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3307857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="161" mass="17271" checksum="B86FEF9FBB1154BC" modified="2024-07-24" version="1">MATADASKAASEAPWYAAYPAPKSEVATISREEVLEMLKTTPLEKRDFILVDLRRNDFEGGTIRGSINLPAQSLYPTLPTLYALFKAAGLQKVIFYCGSSTGRGSRATAWLADHLASVGDTTMKSLALAGGIKGWAAAGQEYVEWMDEYDPAVWAKTGGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GY96</accession>
    <name>A0AAJ0GY96_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_392495</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DCP1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SWI5/SAE3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724158.1">
        <property type="nucleotide sequence ID" value="XM_062864635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GY96"/>
    <dbReference type="GeneID" id="87883464"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031087">
        <property type="term" value="P:deadenylation-independent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13182">
        <property type="entry name" value="EVH1-like_Dcp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010334">
        <property type="entry name" value="Dcp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010760">
        <property type="entry name" value="DNA-repair_Swi5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16290:SF0">
        <property type="entry name" value="DECAPPING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16290">
        <property type="entry name" value="TRANSCRIPTION FACTOR SMIF DECAPPING ENZYME DCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06058">
        <property type="entry name" value="DCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07061">
        <property type="entry name" value="Swi5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3308378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="505" mass="55771" checksum="29DF5FA6A52BDB88" modified="2024-07-24" version="1">MSRPTPRKARHRHHASNSGPRQVNASDYESDTAQYMENREQMAAAPNPEPARDNTELSLRVLRRYQPSIRSILAIAANAVSYTFLEATQGWEKHGIEGTMFVCEQEPIVTPTGQELPRVCVFVLNRRSMDNLVLDLLRVTDFEVVEELMVFRFEDDAGTNNSQGAEDGSAGKKIIGLWIHADESNTREVHASLILNAWQQGRQAFDAYIQAATAGISGGFGPGAESSAAAASRLDGTHPATRQLKSSLCAVRGAPNKPARSLVVTRACLTLNSTSVPTVLPSRSPHCATNIESSSTPRTGEGDDVIHTAVQTQLSLLSSFKQWLARTIESDGDLKALASRLQSRLEDYQRWLCEVERTPSGLVLEDAQPWYIEARVQLGSDNETIIVVAGPGSEESIEIAAEGRKQAEDFLRHGRLGELMTICRAFSKAQDTMSALLRSRREMKQEEAQLSQPAEATVNTYIRRLQEYNDMKDIGQQLMGLVAENRGVPVRTLYETGEYGVNFPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GYL8</accession>
    <name>A0AAJ0GYL8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">FAD binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_524046</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724060.1">
        <property type="nucleotide sequence ID" value="XM_062868738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GYL8"/>
    <dbReference type="GeneID" id="87887567"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF19">
        <property type="entry name" value="BINDING MONOOXYGENASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="6"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="8">
        <location>
            <begin position="581"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3308280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="663" mass="71219" checksum="693B0BC45DC3EB3C" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GYN3</accession>
    <name>A0AAJ0GYN3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_110450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724329.1">
        <property type="nucleotide sequence ID" value="XM_062861493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GYN3"/>
    <dbReference type="GeneID" id="87880322"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="195"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3308549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="267" mass="29161" checksum="80313F31015C1A6E" modified="2024-07-24" version="1">MPGKGHHRSRSSIDRVIDLLADLEENQIAVLLDDLNHTTSSNVPVSDAIALFEHHTSKDIRKNTRSPSPVRALQVELERRHSRRISAAPESGPRAKRASFQPPAPRQPTSLSLPVTQPTDRPGRSDYTGHNDQSLLTLPSPTHVERPQPSSSEASSSGFRPRSYKRISRPTFLSPTATAELHLLLLAFFNGETPASATTTATPSPTTPQFFGMSHSPFSSDFELEEPNTPGLDLLEPSPTRTPSFSSGRSIRTIPSMGSIFEVLSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GYZ3</accession>
    <name>A0AAJ0GYZ3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 19</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 19</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MED19</name>
        <name evidence="11" type="ORF">B0T15DRAFT_115874</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GYZ3"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013942">
        <property type="entry name" value="Mediator_Med19_fun"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08633">
        <property type="entry name" value="Rox3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3308697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="207" mass="22987" checksum="50B47E73B785CAF4" modified="2024-07-24" version="1">MSFHPQTPQSPSLSPGTSDPTTSMTGSLASTTTTLPTPAHSVNGSSLPSEMVHDNIMGETSPRKRKREVDDMGDRAQKKVHVSEKYLICKFPHPLPRPQVSEDLFKMYGLTRLATEVARVLPNGEKNALRKTYKGHIKKLGVQGHFDEVKEDPYRQDGLIALMKTPQDVWDVHFTRGRAMQDGLSHETRQILPRAMTMAKGTPITGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GZ33</accession>
    <name>A0AAJ0GZ33_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_119292</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724592.1">
        <property type="nucleotide sequence ID" value="XM_062861604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GZ33"/>
    <dbReference type="GeneID" id="87880433"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.20">
        <property type="entry name" value="Gas2-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003108">
        <property type="entry name" value="GAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036534">
        <property type="entry name" value="GAR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02187">
        <property type="entry name" value="GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143575">
        <property type="entry name" value="GAS2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51460">
        <property type="entry name" value="GAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAR" evidence="5">
        <location>
            <begin position="676"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="362"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="636"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="756"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="374"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="434"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="535"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="550"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="577"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="662"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="762"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="838"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="874"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="962"/>
            <end position="972"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3308812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="972" mass="104608" checksum="3EF223433DA40378" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H0B4</accession>
    <name>A0AAJ0H0B4_9PEZI</name>
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        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
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        <name evidence="10" type="ORF">B0T15DRAFT_481170</name>
    </gene>
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        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
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                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAUDZG010000001">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725258.1">
        <property type="nucleotide sequence ID" value="XM_062866009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H0B4"/>
    <dbReference type="GeneID" id="87884838"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895">
        <property type="entry name" value="CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895:SF32">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="59"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3309478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H0D6</accession>
    <name>A0AAJ0H0D6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_515523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725227.1">
        <property type="nucleotide sequence ID" value="XM_062868202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H0D6"/>
    <dbReference type="GeneID" id="87887031"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3309447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="255" mass="28655" checksum="11DC8CB50D1ACA10" modified="2024-07-24" version="1">MIVPKMDLYVFAMSAEALMVGNGNRIARHVASSGTYGRPNVRSRYIPHLPGTLTRSRRISAEHTVPSGASHIPIIYRYCKLRQTNVWQYLQTPPFQIRSVKCHLGVLHLCDYRVLQALHAMSPEEDDSICHGSHGHTPMSGTSSDNNNRAGHLLAAEDFLSTLHHGAQKFGFTSSLRKGWQLTKTGPFYMANHSRHKERLVVGSEGIISTSNQGLVYVLSSLVQAFRMDKSYFLLLRHSIPHRLRAVTYWPVTPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H0I4</accession>
    <name>A0AAJ0H0I4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0T15DRAFT_7342</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetyltransferase family. GCN5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725371.1">
        <property type="nucleotide sequence ID" value="XM_062871262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H0I4"/>
    <dbReference type="GeneID" id="87890091"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010484">
        <property type="term" value="F:histone H3 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05509">
        <property type="entry name" value="Bromo_gcn5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000004">
        <property type="entry name" value="Histone acetyltransferase KAT2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037800">
        <property type="entry name" value="GCN5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750">
        <property type="entry name" value="GH11602P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750:SF3">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 12" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="15">
        <location>
            <begin position="57"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="14">
        <location>
            <begin position="300"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3309591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="396" mass="45576" checksum="A956914D9B4C588D" modified="2024-07-24" version="1">MKDENGKRKATDEPSSPVASKRVKHDPSDEPEKQPAKVPAIPFPEKPAVIEERNGEIEFRVVNNDGERESIIILTGLKCLFQKQLPKMPKDYIARLVYDRTHLSIAIVKKPLEVVGGITYRPFKGRQFAEIVFCAISSDQQVKGYGAHLMSHLKDYVKATSDVKHFLTYADNYAIGYFKKQGFTKEITLPESIWMGYIKDYEGGTIMQCTMLPRIRYLEVGRMLLKQKECVQAKIRAYSKSHIVHEPPKQWQKNGVSPIDPLSIEAIRASGWSPAMDELARQPRHGPNYNQLLHLLNDLQNHPSAWPFLVPVNKDEVLDYYDVIKEPMDLSTMETKLEADQYNTPEDFIRDAKLIFDNCRKYNSETTSYAKSANKLEKFMWQQIRAIPEWSHLENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H1Z2</accession>
    <name>A0AAJ0H1Z2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Magnesium transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_32479</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the membrane magnesium transporter (TC 1.A.67) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726078.1">
        <property type="nucleotide sequence ID" value="XM_062864094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H1Z2"/>
    <dbReference type="GeneID" id="87882923"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053279">
        <property type="entry name" value="EMC_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018937">
        <property type="entry name" value="MMgT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28144">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28144:SF1">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10270">
        <property type="entry name" value="MMgT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3310298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="151" mass="16553" checksum="D89CEC272B98CF72" modified="2024-07-24" version="1">MTFLSRVITAFGGLLLTHACYSAREHTALQSLRAATASSLTSSPTVSSSLPLDIILETLISTLIILVGLVLGTRPLRPIEWRVWAGKIEREGEAGFTDGSGVVDRDYMGNPFSVFESRPNFVDIRKQRKEFAEWVQKGGAEATRYYAGGTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H256</accession>
    <name>A0AAJ0H256_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Extracellular serine-rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_25891</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725915.1">
        <property type="nucleotide sequence ID" value="XM_062863295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H256"/>
    <dbReference type="GeneID" id="87882124"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052953">
        <property type="entry name" value="Ser-rich/MCO-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883:SF8">
        <property type="entry name" value="EXTRACELLULAR SERINE-RICH PROTEIN (AFU_ORTHOLOGUE AFUA_6G00670)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883">
        <property type="entry name" value="SERINE-RICH PROTEIN, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042508790" description="Extracellular serine-rich protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3310135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="424" mass="43402" checksum="844FC710642B8731" modified="2024-07-24" version="1">MFALRVLALSAVLASTATAQDDETVTAAPTPTGEAASSSSASSTTSSSSGPATVTIAVGATGHVFTPHEATAKVGDIIRFNFYPGGHRVARAEFGWPCIPYEYANINKAGFYTGIFEPQVVSNNPPHYEVRVNDTAPIFFYCAAPGSCVDYHMIGVINPNATQSYDAQLEYAQNTTYQLAPGEPFPSETPVPRPTPGSGSTISSDSSSGGNGGGSSHHGLSGGAIAGIAIGAAAVLILGAALIYLCGRRGGFDKAYRKTFHVPPSAAAARSTDSPGMVEAKYANGGVGGGVVVDPKSPGQTTLSGASSTFPGHDNASTLRSSYHAGAGQPPYYGIGTSPSPHLTTPSPGLPQYGYANGHHHEGYGGGDYTSPHASPRPDQYTPFVAPPVELPSGDVAVPTQSPPPGYQGRESWQQGGYQPGGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H2C5</accession>
    <name>A0AAJ0H2C5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_41928</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726338.1">
        <property type="nucleotide sequence ID" value="XM_062865527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H2C5"/>
    <dbReference type="GeneID" id="87884356"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12418">
        <property type="entry name" value="RRM_Aly_REF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051229">
        <property type="entry name" value="ALYREF_mRNA_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025715">
        <property type="entry name" value="FoP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965">
        <property type="entry name" value="RNA AND EXPORT FACTOR BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965:SF82">
        <property type="entry name" value="THO COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01218">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
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        </location>
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        </location>
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        </location>
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        </location>
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        </location>
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        <source>
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        </source>
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        </source>
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    </evidence>
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        <source>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
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                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
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                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Cros-Aarteil S."/>
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                <person name="Kuo A."/>
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                <person name="Riley R."/>
                <person name="LaButti K."/>
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                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
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                <person name="Lalanne C."/>
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                <person name="Ament-Velasquez S.L."/>
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                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
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            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
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                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
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                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="3">Uncharacterized protein</fullName>
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    <organism evidence="3 4">
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726475.1">
        <property type="nucleotide sequence ID" value="XM_062865969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H386"/>
    <dbReference type="GeneID" id="87884798"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="29"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3310695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="165" mass="18029" checksum="EBD48DE474DA2FA8" modified="2024-07-24" version="1">MAPAANTARPRRTSGGGRATADSDSDAEYQAYNGRLKEASAARARLRKAKQSRDKHRTALATAYESSLKQIESRIEKSVAKHKDLRTAMHLSHLTRLKQTLDRRDEAAGQIARKLAEHQRRMLNLAIQLRALYEGRKEDVGALMGDAAAVPGGGPAGTGEEVRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H3B5</accession>
    <name>A0AAJ0H3B5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_47819</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726520.1">
        <property type="nucleotide sequence ID" value="XM_062865995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H3B5"/>
    <dbReference type="GeneID" id="87884824"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000021">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF236">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="7">
        <location>
            <begin position="132"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3310740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="248" mass="27635" checksum="ECE0C3BF2D185098" modified="2024-07-24" version="1">MAKDKRSKAPGPPQSTTTTTTKPLTTTAPSWPPFKPSLPVADLALEPLVEDKVVVVRSFFPRSLCRDYISFLRDLPLATTPGKPKRGEAVRVNDRLQLDDAGFANRLWAETGLKEVLLSEDVSHLWGGEVVGLNPNIRIYRYRPGQFFDAHYDDSNNVTVPTGTGSQVSARTTWTLLLYLTSSADGCIGGETVFYPHDRRSVKEEIAVSLETGMLLLHKHGRDCMLHEGREVTAGEKWVIRTDLCIKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H3U5</accession>
    <name>A0AAJ0H3U5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Aminomethyltransferase</fullName>
            <ecNumber evidence="4 12">2.1.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 12">Glycine cleavage system T protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0T15DRAFT_386506</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[protein] + (6S)-5,6,7,8-tetrahydrofolate = N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16945"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10492"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="2.1.2.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the GcvT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.10" evidence="4 12"/>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727099.1">
        <property type="nucleotide sequence ID" value="XM_062864326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H3U5"/>
    <dbReference type="GeneID" id="87883155"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004047">
        <property type="term" value="F:aminomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006546">
        <property type="term" value="P:glycine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.110:FF:000002">
        <property type="entry name" value="Aminomethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1400:FF:000001">
        <property type="entry name" value="Aminomethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1250.10:FF:000002">
        <property type="entry name" value="Aminomethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.110">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1400">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1250.10">
        <property type="entry name" value="Aminomethyltransferase fragment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GcvT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GcvT/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GcvT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCVT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00528">
        <property type="entry name" value="gcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PRK00389.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757:SF2">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006487">
        <property type="entry name" value="GcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="GCVT N-terminal" evidence="13">
        <location>
            <begin position="85"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Aminomethyltransferase C-terminal" evidence="14">
        <location>
            <begin position="391"/>
            <end position="473"/>
        </location>
    </feature>
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        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00011690"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00031395"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006487-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3311319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="482" mass="52169" checksum="97E13F27D39BF69F" modified="2024-07-24" version="1">MQCSRSTSLAKTLRGACRSPSHPARRYASRAIATPALQQQCSAGQSHRPIYQHASTIRPRQHTHPLIQVRHASSSSSEPLQKTPLYDLHLAHGAKMVPFGGFYMPVQYASLSVSQSHLFTREHASLFDVSHMVQRLFSGPGAAQFLQRITPSGVESLAEHRSTLSCLLQSDGSGGIVDDTIVTRLKEGKFYVVTNAACRDKDNAYLETEMAKWNQEAGHEHLQVKEERLDGQGLVALQGPESEGILAQVLADESTLHLKKLLFGQSAYAKLKLRGMQLSSPVLISRGGYTGEDGFEISIPGDETVDVTEALLAAGPEKVQLAGLGARDSLRLEAGMCLYGHDLDDSTTPVEAGLSWIIPKERRSVDAGFYGADVIAKQLVAKSKGGTGVERRRVGLIVEGAPAREGAEIVSRAEEGKEPVKLGIVTSGCPSPSLSKNISMGYIRDGFHKAGTEVDVLVRGRPRKAVVAKMPFVPTRYWKGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H3U8</accession>
    <name>A0AAJ0H3U8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_67221</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAK3311232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727012.1">
        <property type="nucleotide sequence ID" value="XM_062871186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H3U8"/>
    <dbReference type="GeneID" id="87890015"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039136">
        <property type="entry name" value="NUFIP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019496">
        <property type="entry name" value="NUFIP1_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13309:SF0">
        <property type="entry name" value="FMR1-INTERACTING PROTEIN NUFIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13309">
        <property type="entry name" value="NUCLEAR FRAGILE X MENTAL RETARDATION PROTEIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10453">
        <property type="entry name" value="NUFIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="455"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="455"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="362"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="529"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="110"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="199"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="212"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="248"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="274"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="316"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="376"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="432"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3311232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="601" mass="64511" checksum="4693E3D5E2E2F92E" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H3V2</accession>
    <name>A0AAJ0H3V2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DnaJ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_520147</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726800.1">
        <property type="nucleotide sequence ID" value="XM_062868481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H3V2"/>
    <dbReference type="GeneID" id="87887310"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051083">
        <property type="term" value="P:'de novo' cotranslational protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23953">
        <property type="entry name" value="zuotin_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.840">
        <property type="entry name" value="Ribosome-associated complex head domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032003">
        <property type="entry name" value="RAC_head"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042569">
        <property type="entry name" value="RAC_head_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054076">
        <property type="entry name" value="ZUO1-like_ZHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044634">
        <property type="entry name" value="Zuotin/DnaJC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058871">
        <property type="entry name" value="Zuotin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43999">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43999:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16717">
        <property type="entry name" value="RAC_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21884">
        <property type="entry name" value="ZUO1-like_ZHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26185">
        <property type="entry name" value="Zuotin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="5">
        <location>
            <begin position="102"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="319"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="255"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="319"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3311020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="446" mass="50913" checksum="47FB26AEE18349D1" modified="2024-07-24" version="1">MEATVVPLPLPVLPEGWEGENGFKVIGKITKESASQRTLEPVGPYFLAHARRARHKRTFSEDDRIQAQERAKKVEDDNDSEISEPEDAMMLQRDAKDWKTQDHYKVLGLSKYRYKATEEQIKRAHRKKVLKHHPDKKAAAGRADDDNFFKCIQKATEILLDPVKRRQYDSVDEEADVDPPTKKQLAKGNYYKLWGNVFKSEARFSKVHPVPSFGDENSTKEEVENFYNFWYNFDSWRTFEYLDEDVPDDNENRDQKRHMERKNANARKKKKAEDNARLRKLLDDCSAGDERIKRFRQEANAAKNKKRLEREAAEKKAAEEARLKKEAEEKAAKEAEEKAKADREAAKKAKEAAKNAVKKNKRVLRGSVKDANYFVEGDASAATIDAVLGDVELVQAKIDADEIAALAGKLNGLKVADEIKSVWKEEVERLVAAGKIKEGEVKALVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H3Y4</accession>
    <name>A0AAJ0H3Y4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">SEN1 N terminal-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0T15DRAFT_548822</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727156.1">
        <property type="nucleotide sequence ID" value="XM_062870204.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87889033"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001147">
        <property type="term" value="F:transcription termination site sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18042">
        <property type="entry name" value="DEXXQc_SETX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000326">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001152">
        <property type="entry name" value="tRNA-splicing endonuclease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024481">
        <property type="entry name" value="Helicase_Sen1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056474">
        <property type="entry name" value="SEN1_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF495">
        <property type="entry name" value="HELICASE SENATAXIN ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23576">
        <property type="entry name" value="SEN1_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12726">
        <property type="entry name" value="SEN1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase Sen1 N-terminal" evidence="9">
        <location>
            <begin position="90"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase SEN1 beta-barrel" evidence="12">
        <location>
            <begin position="1171"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="10">
        <location>
            <begin position="1319"/>
            <end position="1610"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="11">
        <location>
            <begin position="1617"/>
            <end position="1813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="24"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1858"/>
            <end position="2068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1896"/>
            <end position="1905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="2016"/>
            <end position="2032"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="2068"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3311376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="2068" mass="231221" checksum="52C8E2F3A2F44E65" modified="2024-07-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H450</accession>
    <name>A0AAJ0H450_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_386889</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727264.1">
        <property type="nucleotide sequence ID" value="XM_062864351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H450"/>
    <dbReference type="GeneID" id="87883180"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21383">
        <property type="entry name" value="GAT_GGA_Tom1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038425">
        <property type="entry name" value="GAT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50909">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="6">
        <location>
            <begin position="49"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="GAT" evidence="7">
        <location>
            <begin position="218"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="314"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="285"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="351"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="407"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="466"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3311484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="475" mass="51303" checksum="905667C7686128B6" modified="2024-07-24" version="1">MAGFSMNKVLGTMKKRPTFGGGSAAETPVDPANETPEAVATRCVKQFCNSVGSASGDDVVFLPSIVEAAVASPVAAAECARLIRKFMSKDYWTKPSCQYNAVMLIRILVDNPGPGFTRYMDKKFVDTAKELLRTGRDASVRQILMETLDSFENTRASDEGLALMIEMWKKEKEKAYKAYGGVPVAPGPRGMIAPPFDPRHQHHQPYYQQSQHHSKRLPDPIELANRLEEARTSAKLLEQVVACTPPLEVLSNDLIKEFADRCTSASRSIQGYMSAENPGPDNDTMESLIDTNEQLQQALNHHHRAVLQAKKQLGVNDGRSSNSSPAPPSQRPPAGQPRSPPPQVPRKGVAGSSSSSNGNGKGKSNLDVLRSSAIAGPSRSTNATPRHDTNEDDDDGQDPFRDPEPAGSSSRAAGNMSGSTPRLSYEPFHPGFGGSSSSAAAGGEKARREPATAVSDEEEDAYRATPKKEGRENRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H451</accession>
    <name>A0AAJ0H451_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ankyrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_548513</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726985.1">
        <property type="nucleotide sequence ID" value="XM_062870198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H451"/>
    <dbReference type="GeneID" id="87889027"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050889">
        <property type="entry name" value="Dendritic_Spine_Reg/Scaffold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166:SF48">
        <property type="entry name" value="PROTEIN VAPYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166">
        <property type="entry name" value="ROLLING PEBBLES, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="432"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3311205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="498" mass="54816" checksum="0C3AE597BB879CDC" modified="2024-07-24" version="1">MEAASQSTATSYESDDFPIATLDNTPNELGEEPVPTYTRTDTTPVTTLLDTLPLSISRHLQLPLTSYPAPPQTWDATAAATTHPLPRDPTLTYSEKIAVYKSQQQIIASFFSAISSRNIEAVTLLVQRGLVSPDVPDSLTPGRTPLITAVEAGDGAMVCTLVGLGAHVDGWGQRTALMVAAARGNLALVRLLREDFGADDAAIAPDDGQLALRLAAEAGHRDVVEYLPARRGGAWRRWESHHAVAMARARKAARGIYVFFRALLYYVPRCFLWDVPKHAVMKPLGKAGKWCWVNKHRFGPWCKEQARKFPGRAKRAGKAVWRGARMVPRVVWGVAKGIPRVVERLLRWLWTVVITRIPAAMKQVCVWIWESLKRVGKAVGHAFLRIVGALHTAIAAVLDFFRNIRVRDVWNGVCDVCEAVFVGLPRAVWRGIVSAGAVAAGVVIGLFGLTGKLVVFLVKVLWYVAKYVPQQLVAIISAIWTSVAKGYHEILVWINPKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H4C7</accession>
    <name>A0AAJ0H4C7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_80483</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727373.1">
        <property type="nucleotide sequence ID" value="XM_062871337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H4C7"/>
    <dbReference type="GeneID" id="87890166"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052099">
        <property type="entry name" value="Regulatory_TF_Diverse"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="237"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3311593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="377" mass="40402" checksum="044F796FC393A386" modified="2024-07-24" version="1">MSGATIASSMSFDMSATSFDGSQLQVPTYSDFSQVSLFDTEDFGTDFTSDSAHSPLSPLSPALSASSFGLPAAEAYTTWDAAEMYVETENLFDCQTFGSDSSLSPAINPLDLRVKPRMYQSQAMSASVPAQQQQQQQYQSQGVHQQELAAQATAPLLASPTSSTSRSASPSSTTTADAGPKRYPSRVPKRKLGSEEEPATRPANAAPTATTQPTTTPSTRRVPFKSKDSSDSGVLAPKKTAHNMIEKRYRTNLNDKILQLRDAVPSLRLMAQRAKLAEEGGSAESEDAGAGAGDVSMDSSAGMNFETCTTKLHKATILSKAAEYIQQLEYRNHGLETENLALRERMQGLEIMLFGKQAAAARLGMETGGEGFSSTWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H4I7</accession>
    <name>A0AAJ0H4I7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_508218</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727459.1">
        <property type="nucleotide sequence ID" value="XM_062867704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H4I7"/>
    <dbReference type="GeneID" id="87886533"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14686">
        <property type="entry name" value="bZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031106">
        <property type="entry name" value="C/EBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23334:SF20">
        <property type="entry name" value="BASIC LEUCINE ZIPPER 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23334">
        <property type="entry name" value="CCAAT/ENHANCER BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042480038" description="BZIP domain-containing protein" evidence="3">
        <location>
            <begin position="25"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="BZIP" evidence="4">
        <location>
            <begin position="336"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="234"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="341"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="234"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3311679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="404" mass="44324" checksum="E5663AF5703779F5" modified="2024-07-24" version="1">MLVAWRLTILSPALFVPFLPGVDARSKQPAGLVDLGYHPTCANTGTGFETVLLPADLDCSLPDGQQDSAGSRQWGLAWIQGHISVGVKELRRVDVFEVRMQRRIIWWTHFRPLPQGGRHSALQEWPHPYSPEWHALVSSLSSSTSLSYAACHSLPPSSQHNDFDLLNPFAWDQAAANYLDLDPASTAATDLSSLPTPELDQQHNDNVPTPHFDTSTPFLDCFPSTSFPVPLSYSTDTSLSNTPSTSTVQSPPDEAPNNNSNGAAALVPGLKLPPQRPSNKPGRKPAAASSLTRTTDGRITKKRITTTTTTTPSGRASLLFPAGDELDDDPDDVVLRRQRNNLAAKRYRQKKLDRIEELEKEVERVKQERDELKIRVARQEAEVAALREMLQLQKGGGSGTGSKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H500</accession>
    <name>A0AAJ0H500_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kelch repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_389206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727375.1">
        <property type="nucleotide sequence ID" value="XM_062864476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H500"/>
    <dbReference type="GeneID" id="87883305"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042477812" description="Kelch repeat-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3311595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="416" mass="45544" checksum="572D1EA122AC71D5" modified="2024-07-24" version="1">MRSGRLGSGLAALFGLGSVAVVGVAGLSDAPTVDNFIRRGTQSATVIGNYVYIDGGEISQYSDGTAILGRTSNQVNSTLSIDLSKSWTTSDVAFKIIERPWWSKACQAIWTNHDEGTFYVWGGKWIWGMNMTENQLWKFTPDGNGGGGWAVEEPTNANLFKGLHQSEFGAYASSNDTGFYIGGIASGWTELYRARNQVLPGMVTYDMKSKVWDNGTTAFSPFTTLAGAAAHYIPTFGPNGLVMVFGGSSHSVVGEPDWSAARSWDFRNLTFFDPRSKKQYWQATTGDIPPDAPRAFFCVAGFPNSDGGYEIFLSGGSNQRTQVQYQDAYVLSLPGFVWRKAADSPGGARSWHNCLSVGKRQVLSIGGWTGDWTKKDAYAQGLKLFDMTEMTWKDSYDATVAMYERNADLKSWYTNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H590</accession>
    <name>A0AAJ0H590_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine phosphatase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_522356</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727510.1">
        <property type="nucleotide sequence ID" value="XM_062868621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H590"/>
    <dbReference type="GeneID" id="87887450"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050278">
        <property type="term" value="F:sedoheptulose-bisphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046390">
        <property type="term" value="P:ribose phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07040">
        <property type="entry name" value="HP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF15">
        <property type="entry name" value="SEDOHEPTULOSE 1,7-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="1">
        <location>
            <position position="16"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="28"/>
            <end position="29"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="102"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3311730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="130" mass="14631" checksum="D4C75E3243FBD7AB" modified="2024-07-24" version="1">MSDQDALTPRVFLVRHRETSWAKSGRHTGTIEIELTAEGAAQVSSTTASLVGAGKLLDPSRLVYVFISPRTRTRRTFELLLSPSLGTGEWNKSVTYTEDIAEWNYGDYKGLMAGEIRKLRKKKGLDRERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZF1</accession>
    <name>A0AAJ0LZF1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_495808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719023.1">
        <property type="nucleotide sequence ID" value="XM_062867126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZF1"/>
    <dbReference type="GeneID" id="87885955"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3303243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="173" mass="16397" checksum="6768E24AAE7DA881" modified="2024-07-24" version="1">MADRGNPPALAFGAFDNLKGKLKAAFKKRGEKKKAAKADPKKTEDKKPEEATATATAPAAGAAGAAAAATEATKTETAAAPAAAPAPVAEAATTAPAVEAPAVEAPAAAEQKAAETPAAVAPAVEATPAPAPAAAPATPATATETAAAPATEEPKKEEPAAAAAAAPAPAPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZG0</accession>
    <name>A0AAJ0LZG0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose 1-dehydrogenase (NADP(+), D-xylono-1,5-lactone-forming)</fullName>
            <ecNumber evidence="3">1.1.1.179</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">D-xylose-NADP dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_495963</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-xylose + NADP(+) = D-xylono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22000"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15867"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.179"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.179" evidence="3"/>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719187.1">
        <property type="nucleotide sequence ID" value="XM_062867137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZG0"/>
    <dbReference type="GeneID" id="87885966"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047837">
        <property type="term" value="F:D-xylose 1-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050984">
        <property type="entry name" value="Gfo/Idh/MocA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604">
        <property type="entry name" value="OXIDOREDUCTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604:SF105">
        <property type="entry name" value="TRANS-1,2-DIHYDROBENZENE-1,2-DIOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="48"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3303407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="210" mass="23164" checksum="FE89A3AFE220D4D0" modified="2024-07-24" version="1">MNLSVGFKEWAQRHIRSRFFPPTPPTKAGNALRFGIMSGGSVAPEVLIDPARLHPEVVVAAVVAATNSARAERFAKEHGIPRVLTSFDELINDPTIDAVYIGAGMDAQRLFHSFPILRPDGPVFLEAIPYRFHPSWIEFQRRIDKYRVSEVRVTVMTPVASNAAPGNARFMAEQSGSARMGPAYAFSILQGIFGFGVPRCEQWNVSQSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZI7</accession>
    <name>A0AAJ0LZI7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)</fullName>
            <ecNumber evidence="2">1.2.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_540351</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 3-methyl-2-oxobutanoate + H(+) = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13457"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10497"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83142"/>
            <dbReference type="EC" id="1.2.4.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:13458"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.4" evidence="2"/>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719261.1">
        <property type="nucleotide sequence ID" value="XM_062869782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZI7"/>
    <dbReference type="GeneID" id="87888611"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003863">
        <property type="term" value="F:branched-chain 2-oxo acid dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009083">
        <property type="term" value="P:branched-chain amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006091">
        <property type="term" value="P:generation of precursor metabolites and energy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007584">
        <property type="term" value="P:response to nutrient"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07036">
        <property type="entry name" value="TPP_PYR_E1-PDHc-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42980:SF1">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42980">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="6">
        <location>
            <begin position="79"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="24"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00051764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3303481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="403" mass="43653" checksum="9990E95E6D5F288F" modified="2024-07-24" version="1">MAGTSIRTLSRVLTRGSSLASSTPALVSSRRQYSSHPPNARLNLPTDYSTTPLLAHSSQSALSNPELPPEARNGTTKRMNLFQAVNDALSIALAEDESVLIFGEDVAFGGVFRCTGKLAETYGGARVFNTPLTEQGIMGFAIGVAAEGMRPVAEIQFADYVYPAFDQLVNEAAKFRYRDGACGRSAGGLTVRMPCGGVGHGALYHSQSPESLFTHIPGLRVIMPRSPLQAKGLLLSAIRSNDPCVFMEPKILYRAAVEQVPTAAYTLPLSKAEVLKEGSNVTIVSYGQPLYKCMAALKQAEHDFGISVELIDLRTIYPWDKETVFQSVRKTGRCLVVHEAMINAGVGAEVAAAIQEDPETFIRLEAPVARVAGWSIHTPLLYEAFNAPDVARIYDNLKKVLEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZL4</accession>
    <name>A0AAJ0LZL4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_540440</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Required to prevent the proteolysis of the CreB deubiquitinating enzyme in the absence of carbon catabolite repression. CreB deubiquitinating enzyme stabilized in a complex with the CreC leads to the expression of genes such as those in the proline and quinate pathways.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Interacts with creB.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat creC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719294.1">
        <property type="nucleotide sequence ID" value="XM_062869786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZL4"/>
    <dbReference type="GeneID" id="87888615"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045013">
        <property type="term" value="P:carbon catabolite repression of transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051362">
        <property type="entry name" value="WD_repeat_creC_regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14107:SF16">
        <property type="entry name" value="AT02583P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14107">
        <property type="entry name" value="WD REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="415"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="106"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="106"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="120"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="141"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3303514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="494" mass="54673" checksum="02DBF68B8CE4CD30" modified="2024-07-24" version="1" fragment="single">MFVLPPPPRYTSQQGYNGMSASQPMPMIETNNVLTNPSGPEYQFLVGEGLYVLKEDLHLATPPPHPSEAPVVNPNPLATAPQPATAGTRLSLINLDVSPLSPAFYRTTSRSDGAQGSIQEHVEEGQSSSDVRESSSDAGRLNSSDAQLVASNTPAFGEGNSFLAPTSQKDAHKRRKPKNNMAKSNSSFISRVINHEALSKRLQDRPRDGLFAFGNVNRAFQWLDLSSPMKAEYLTKILFTKAHCLCHDVNKVTKSSTHIDVIMGFSTGEIIWWEPITQRYTRLNKNGIVNGTPVSEIGWIPGSESLFLAAHMDGTLVVYDKEKEDAIFTPEDEGISRTSGETSGTGRVNYSSQIHVHKSVHSKNQKTNPVAVWKLCNHRINAFAFSPDNRHLAVVSEDGTLRIIDYLKEELLDLFYAYYGGLTCVCWSPDGKYVVTGGQDDLISIWCPFDQAPNTALIARCQGHHSWVTSVAFDPWRCDDRNYRFGSVGEDRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZQ9</accession>
    <name>A0AAJ0LZQ9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_282275</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719471.1">
        <property type="nucleotide sequence ID" value="XM_062863596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZQ9"/>
    <dbReference type="GeneID" id="87882425"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05227">
        <property type="entry name" value="AR_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF579">
        <property type="entry name" value="3-BETA HYDROXYSTEROID DEHYDROGENASE_ISOMERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G02250)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="8"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3303691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="348" mass="37646" checksum="A5AFF29473A9D48D" modified="2024-07-24" version="1">MTQTIQYVLVTGATGFIGAHVVDQLLSRGIRVRGATRSLAKGEAMVKARPQYAGQLDFVQIRDFDGVSEADEASIFEDAVKGVDGVIHTASPLTYNTTDNEKELILPAIAGVRAILTAASRAPSVRRVVLTSSFAAVMDANRAAPPYFTYTAADWNPLSYAEAADAATSAVIAYRGSKKFAELAAWDFVRDRAPHFDLATLCPPMTFGPVVHPVESVDRLNESNAMLWKVASGQRPLPVARVPFWVDVRDVAQAHVEALLRPGAGGKRFLPAAPERFSYGLAARIVLEEFDWAKARGVREEEQTIDESHGVDGETAARELGLRYRSFRQTAKELVAQAAAMKGAGLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M0E5</accession>
    <name>A0AAJ0M0E5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC transporter transmembrane region 2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_239573</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720165.1">
        <property type="nucleotide sequence ID" value="XM_062863051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M0E5"/>
    <dbReference type="GeneID" id="87881880"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03223">
        <property type="entry name" value="ABCD_peroxisomal_ALDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000636">
        <property type="entry name" value="ATP-binding cassette sub-family D member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF69">
        <property type="entry name" value="PEROXISOMAL LONG-CHAIN FATTY ACID IMPORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="473"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3304385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="719" mass="81490" checksum="1DE09616FB770BD9" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M0M5</accession>
    <name>A0AAJ0M0M5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GrpE protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_399701</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the GrpE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720389.1">
        <property type="nucleotide sequence ID" value="XM_062865024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M0M5"/>
    <dbReference type="GeneID" id="87883853"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.22.10:FF:000002">
        <property type="entry name" value="GrpE protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="GRPE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237:SF23">
        <property type="entry name" value="GRPE PROTEIN HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="Coiled-coil domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01071">
        <property type="entry name" value="GRPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="50"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3304609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="247" mass="28165" checksum="89BC1CF012BA38CA" modified="2024-07-24" version="1">MLRQTISATSRALRSTVRPGTQRPTITLVQSYQRPLAAARALVPRTRWYSSEADASKAEESKNNGEEAKKQGEEESPEATFKKQLEAKDAEIRDLKDRYLRSVADFRNLQDRTARDMKAARDFAIQRFAQDLVESVDNFDRALSMVPEEKLKTPVEGQEKAEHQQDLVNLYEGLKMTETILLQTLKKHGLERFDPSGLVFNPNEHEATFMTPMPDKEHNTVFHVQQKGFKLNGRVLRPAKVGVVKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M0M6</accession>
    <name>A0AAJ0M0M6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_244237</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720298.1">
        <property type="nucleotide sequence ID" value="XM_062863102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M0M6"/>
    <dbReference type="GeneID" id="87881931"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="57"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="170"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="57"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3304518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="293" mass="31201" checksum="47FD4641040D41BA" modified="2024-07-24" version="1">MSSAPWDYIAKLVCIGDSGCGKSSLTIRLCEGRFVTHHDVTIGVEFGSRIVPVGPPYSTTSCTTSPSSSQSPPDGKEPPAASGLPEPPTIQASSQKHMKLSLWDTAGQETYKSVTRSYFRGASGALLVFDLTRKSTFQHAIDWLNDLRQIAEPDIVVVLVGNKADLASPDAVVEEDADDSRRPEAQAQAQAQEAKAGGGLRGGNKREVTRQEAEEWARRNGVLEYVETSAKSGENVEMAFMRVAERIFQNIQAGKYDLNDRRSGVKGASAGGGVPRGGGTVRLKSQAAAGGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M0R3</accession>
    <name>A0AAJ0M0R3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_558686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720507.1">
        <property type="nucleotide sequence ID" value="XM_062870479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M0R3"/>
    <dbReference type="GeneID" id="87889308"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042564311" description="Ig-like domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3304727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="505" mass="53668" checksum="7AF6199826E6EEF5" modified="2024-07-24" version="1">MAVSISHFLLVASAVVLVSGQFGQIPAPSPHAGCTESSFSIPSWLIQNVKYTDDNVTFDLQNRATNSTASLGCPRKESGYNPCSIQGPPSSNLTLGAAVQVGETSATFLVKETWTCSDRGKSLTFNAAGNNSAALNYTSPILVKGSLYSPVAITPAYADGPKGHDSPGCTAKSEKPSWVLSLIHFTDEPGDASTAPFQNFNLIVTNPATGYQASCMPGGSFGDTPNLSPLVCAGDEFQSSRVGLHPITTQASFDPVTSSFTLNQTWFCDDTDAAKPLQINAAGSTTLPLQCTTQEVNNNRTNKYCTVDGDVTLPGKLGTVVTLAPYSLEDPTPQSRGDGCTLTSIFHPAWQFSNFEVTTIADDHTNSSSVVTSFEVILAAENRGFQYPIPIYQGQALGGGDDNDDDDGGFFQCDIGADGGNDLPLWPYQCRFRYAPERKELVLEAEWACLDLDGANPVKFSGATTTIINSSLTCETVDGRSRCATADPGYTWVAEIANVTWGKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M185</accession>
    <name>A0AAJ0M185_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Catenin-beta-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_502380</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721019.1">
        <property type="nucleotide sequence ID" value="XM_062867434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M185"/>
    <dbReference type="GeneID" id="87886263"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:001136">
        <property type="entry name" value="Beta-catenin-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039678">
        <property type="entry name" value="CTNNBL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013180">
        <property type="entry name" value="CTNNBL1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14978:SF0">
        <property type="entry name" value="BETA-CATENIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14978">
        <property type="entry name" value="BETA-CATENIN-LIKE PROTEIN 1 NUCLEAR ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08216">
        <property type="entry name" value="CTNNBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01156">
        <property type="entry name" value="DUF1716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Beta-catenin-like protein 1 N-terminal" evidence="7">
        <location>
            <begin position="97"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3305239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="600" mass="66520" checksum="8DB06456CE70665F" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M1C1</accession>
    <name>A0AAJ0M1C1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">O-methyltransferase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_396965</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721048.1">
        <property type="nucleotide sequence ID" value="XM_062864874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M1C1"/>
    <dbReference type="GeneID" id="87883703"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF16">
        <property type="entry name" value="O-METHYLTRANSFERASE ELCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005739">
        <property type="entry name" value="O-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="5">
        <location>
            <begin position="195"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR005739-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3305268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="412" mass="46234" checksum="0D51DA6A9B6C7A59" modified="2024-07-24" version="1">MEGSKIADKLDALAQTLSGVAQKLRAGKVSLQTDTEQRMELVKAGNELINTVSQPEDKVHLYLTQLCHMTALRLFLKWDAFDKIPKGRRSDGTPLTISYIQLANKLGADVSLITRLGKVLVANGTLEQRIEIVERLAHTPFSARLTTPQQKATMELLFEDHCPTLMALPDYFNHFGRIEPKDRLQTPVAFAAGMLGSPAWDIIQSDERRRKTFMLAMSTGLEWAIFQSTYDFSWIVREAKKQPSDRVIFVDVGGGRGQVLKNLFDTYPTLPREQCVLEDLPGVIDQAKREQQPELAGVQMVGMDFHKEQPIKGALVYYIRRCLHDYHDETCVGILRQIANAMVLDSRLLISETVINNPPTAYQSAIDLMMLLLSGKERGLDGFKEMADQAGLVVTQALYAREDNGVIECVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M1V1</accession>
    <name>A0AAJ0M1V1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glycosyltransferase family 4 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_533845</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721695.1">
        <property type="nucleotide sequence ID" value="XM_062869387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M1V1"/>
    <dbReference type="GeneID" id="87888216"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03792">
        <property type="entry name" value="GT4_trehalose_phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052078">
        <property type="entry name" value="Trehalose_Metab_GTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049438">
        <property type="entry name" value="TreT_GT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47779">
        <property type="entry name" value="SYNTHASE (CCG-9), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12100)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47779:SF1">
        <property type="entry name" value="SYNTHASE (CCG-9), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12100)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21269">
        <property type="entry name" value="TreT_GT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Trehalose synthase N-terminal" evidence="8">
        <location>
            <begin position="228"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="7">
        <location>
            <begin position="449"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3305915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="700" mass="78381" checksum="419BF94E84ED2BFB" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M267</accession>
    <name>A0AAJ0M267_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_137761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722111.1">
        <property type="nucleotide sequence ID" value="XM_062861841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M267"/>
    <dbReference type="GeneID" id="87880670"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3306331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="296" mass="32406" checksum="188ADB139E8274A9" modified="2024-07-24" version="1">MSEDGNQLHLVRDATTDGATILVRMLADGGVPTAIGGIIAATHYGGGLCPLDIELIVNGADQERAFNILTSHGARPSVPEDPEQQQQQQQQQQQQPATFQQWRERAPYYRFGDRRRMRLCCVPIYELPETGDPVDDALRPFVILYSAETVGLPGLRLTGRGSGETAAAAASECGSSYTPISSIVTAYRATSTCLVPTFRCLVAAEMHVLLRHADYQSLPWGQHAAQLSELLRSPSCPGGYDSLPELVNPELARFADWMRLYLRDGSVDGDLGQLKEAYCRRMTSSQDTTDHSSCMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M268</accession>
    <name>A0AAJ0M268_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_534697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3306213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721993.1">
        <property type="nucleotide sequence ID" value="XM_062869454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M268"/>
    <dbReference type="GeneID" id="87888283"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042491363" evidence="1">
        <location>
            <begin position="17"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3306213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="211" mass="22624" checksum="59F30FCFB4DB5E04" modified="2024-07-24" version="1">MKTGLITALFAGAALSSPMAAADDGPVSTPSPTTLQPGAYWIRAVVPPNYHKYLQTKPANVAGTAILDSHTTAGQFNVEDGQLVNKVSSPPLYLWVEEPADKASPPPRTLATFFNTTRNPFGTFAWQGDTLTWSVPSIKRQNVAAWLVCANQALFINTGAYGYQTPAGCADQTVGFLFFLLSPPLLFCLPSASSDIFNCITVLFVCCRSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M2P6</accession>
    <name>A0AAJ0M2P6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_552707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722518.1">
        <property type="nucleotide sequence ID" value="XM_062870303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M2P6"/>
    <dbReference type="GeneID" id="87889132"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35605">
        <property type="entry name" value="ECP2 EFFECTOR PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35605:SF1">
        <property type="entry name" value="ECP2 EFFECTOR PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042530888" description="Secreted protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3306738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="210" mass="23544" checksum="21A67E9B9E787D84" modified="2024-07-24" version="1">MKISLSALSCIFYGTLSIALLSPSRIHNETVPRRRPLSVFACDERCIENYRKRLSIRDDEASTTESKLNPADWMRILEAILADRHDIMLKDLSPVQLRAFNGKIECGMQFGKRAIAKTIQGQVRTLDKRGGICHVEARTCLRLACARGGAITWCNDGDKPVARQCRDIATDAKSVMARCKHGHPKHGIIWTRGQIRDSDTTRVLVNKALC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M2W4</accession>
    <name>A0AAJ0M2W4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BAR domain-containing family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_529067</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722835.1">
        <property type="nucleotide sequence ID" value="XM_062869077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M2W4"/>
    <dbReference type="GeneID" id="87887906"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07600">
        <property type="entry name" value="BAR_Gvp36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018859">
        <property type="entry name" value="BAR_dom-cont"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10455">
        <property type="entry name" value="BAR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAR" evidence="2">
        <location>
            <begin position="17"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3307055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="322" mass="35333" checksum="9CB487668B85CF31" modified="2024-07-24" version="1">MDAFKGLGKSLSSLGGQITPFASRTFQYTKEQLGQADDKTQLPPDYIDLEKRVDALKAVHQKMLAVTSQYSHEAYDYPPNIKETFQDLGRTVSEKVQLLSTATSPAEAQAALTAPPTAKPQPKTFHHAVARASLASSQTLHQQHTGAGDDPLATALEKYALAMERVGEARLAQDAQIQSRFLAGWNTTLNTNIMFATRARKAVEKARLTLDAVKARVKGTTWKLGGSSPRAEAHEEPELSPEAQEEIEKAEDEFVTQTEEAVGVMKNVLDTPEPLRNLAELIAAQMEFHKKAHEILSELAPIIDGLQVEQEASYRKSRESAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M2X0</accession>
    <name>A0AAJ0M2X0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ARP5-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_164456</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722876.1">
        <property type="nucleotide sequence ID" value="XM_062862147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M2X0"/>
    <dbReference type="GeneID" id="87880976"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10211">
        <property type="entry name" value="ASKHA_NBD_Arp5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000087">
        <property type="entry name" value="Actin-like ATPase domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000139">
        <property type="entry name" value="Chromatin remodeling complex subunit (Arp5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="428"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="514"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="304"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="560"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="435"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3307096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="786" mass="88893" checksum="E6F6033E6B89A77A" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        <lineage>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062869062.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87887891"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41805">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41805:SF1">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN FYV7"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
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        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
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        </location>
    </feature>
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        <location>
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            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3306978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="28708" checksum="99E4B754DC5A0F41" modified="2024-07-24" version="1">MCAKRARDEDAISEAGTSPAPEDTRKPKKAKHGFRVGPENLPDGPWRRKVTKIKKELITKAKVKKQYAKIKAEHQKQATASTTTQTVTEENTKAEDSAGAPARSEPQQQEHDFPPPAPAQIHPYRQAMLGSASQPSKLDNEESQPKQPDQQVSGEDTAGARPERRQQRRHPRKQRPDYFARELAAAERAKKQAEERAAELARREQERQQRIAERERYRKMMAKAKTPGKDGKRKIGREGKVLLERVKKVMGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ0M2Z6_9PEZI</name>
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        <submittedName>
            <fullName evidence="3">CRAL-TRIO domain-containing protein</fullName>
        </submittedName>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
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                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
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                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
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                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
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                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
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                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GeneID" id="87887938"/>
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    <dbReference type="InterPro" id="IPR051026">
        <property type="entry name" value="PI/PC_transfer"/>
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    <dbReference type="PANTHER" id="PTHR45657">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
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        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G09260)-RELATED"/>
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            <begin position="398"/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M3B0</accession>
    <name>A0AAJ0M3B0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">B0T15DRAFT_181178</name>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723296.1">
        <property type="nucleotide sequence ID" value="XM_062862312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M3B0"/>
    <dbReference type="GeneID" id="87881141"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40640">
        <property type="entry name" value="ANCHORED GLYCOPROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40640:SF1">
        <property type="entry name" value="ANCHORED GLYCOPROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042594826" evidence="2">
        <location>
            <begin position="24"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3307516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="220" mass="22693" checksum="9080BB60758597CA" modified="2024-07-24" version="1">MMRSQGPAALLAWLCAAASSALAQLTVSVFLPEYSDSDWVALRGSILSSSPLTTAPQDNSATAYTVFCAEQAPSCQIAGELPFVFTEGPHTLVYTGSDPGTLTADLRCELDGTTAATCTGSSSFGSNYRDGTLTGPTQTSWTKTFAAADVTWGVLALTTPGPLPGTTDIDGTVAATVTSSGSIPEPTTSGAHRQRRVRAGMAGSMFMMVVAVMLGFLQFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M3D6</accession>
    <name>A0AAJ0M3D6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ysc84 actin-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_554450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723371.1">
        <property type="nucleotide sequence ID" value="XM_062870354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M3D6"/>
    <dbReference type="GeneID" id="87889183"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11524">
        <property type="entry name" value="SYLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051702">
        <property type="entry name" value="SH3_domain_YSC84-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007461">
        <property type="entry name" value="Ysc84_actin-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629:SF8">
        <property type="entry name" value="DUF500 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G07310)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629">
        <property type="entry name" value="SH3YL1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04366">
        <property type="entry name" value="Ysc84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ysc84 actin-binding" evidence="2">
        <location>
            <begin position="161"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="547"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="603"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="636"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="648"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="691"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="730"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3307591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="758" mass="81990" checksum="73613939F13423F2" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M3L9</accession>
    <name>A0AAJ0M3L9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Mannose-6-phosphate isomerase</fullName>
            <ecNumber evidence="5 12">5.3.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B0T15DRAFT_522671</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>D-mannose 6-phosphate = D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12356"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="5.3.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11 12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 14">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the mannose-6-phosphate isomerase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.8" evidence="5 12"/>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3307816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723596.1">
        <property type="nucleotide sequence ID" value="XM_062868644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M3L9"/>
    <dbReference type="GeneID" id="87887473"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07011">
        <property type="entry name" value="cupin_PMI_type_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.441.10">
        <property type="entry name" value="Phosphomannose Isomerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001250">
        <property type="entry name" value="Man6P_Isoase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016305">
        <property type="entry name" value="Mannose-6-P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018050">
        <property type="entry name" value="Pmannose_isomerase-type1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046456">
        <property type="entry name" value="PMI_typeI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046457">
        <property type="entry name" value="PMI_typeI_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046458">
        <property type="entry name" value="PMI_typeI_hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00218">
        <property type="entry name" value="manA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309:SF0">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01238">
        <property type="entry name" value="PMI_typeI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20511">
        <property type="entry name" value="PMI_typeI_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MAN6PISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00965">
        <property type="entry name" value="PMI_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00966">
        <property type="entry name" value="PMI_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12 18" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phosphomannose isomerase type I catalytic" evidence="16">
        <location>
            <begin position="5"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphomannose isomerase type I helical insertion" evidence="17">
        <location>
            <begin position="167"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphomannose isomerase type I C-terminal" evidence="15">
        <location>
            <begin position="358"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
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    <feature type="binding site" evidence="11">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
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    <feature type="binding site" evidence="11">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000757"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00002564"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004666"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010772"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011956"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00018236"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR001480-1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR001480-2"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01238"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF20511"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF20512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK3307816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="453" mass="49021" checksum="1CEC9CDC8C0386AE" modified="2024-07-24" version="1">MQVPLIRLQCGANSYEWGKKGSASAVARFAAATPSDDFAVQDDRPYAELWMGTHPSNPSKDVTTGRTLLDLVQDNKALLASSVAARYENKLPFLFKILSIGKALSIQAHPNKKLAEQLHARDPRNYPDDNHKPEMAIAITPFEGLCGFRPLEEIAHFLRSVPALRQLVGDDKAKEFANLVESTKDDESAEAVERRKKALQKVFAAVMSSSEADMAAATKVLVESTASAGSDFAGGGVSATSGSVLAELVTRLHGQFGPDYGLFVLFFLNYVTLQPGEALFLRADDIHAYVSGDIVECMASSDNVVRAGFTPKFKDVGTLVNMLTYNYAPIDEQKMHPVDYPYATLNRTAYSSGSAITLYDPPIDEFSVVRTNLRGSGAKATFDPVDGPSIIICTAGKGKISVGPTVQEIKEGYVFFVGATAECVLESEGASDDDEFITFKAFCEVEDHRNGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M475</accession>
    <name>A0AAJ0M475_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase family 16 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_490759</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723944.1">
        <property type="nucleotide sequence ID" value="XM_062866714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M475"/>
    <dbReference type="GeneID" id="87885543"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02181">
        <property type="entry name" value="GH16_fungal_Lam16A_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF42">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_5G02280)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="2">
        <location>
            <begin position="66"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3308164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="383" mass="41836" checksum="656DBBF180A4BEBD" modified="2024-07-24" version="1">MRPNEPKVTAYEARESHISRSEWDPRSWSRRIWLILVTIIIIIVVAIVATVVGVRATRNSGNGKDDRYPNYTRLNYTLVDTYSGTSFFDKFDYFNTYDPAGGFVHYVSPGDAKLHNLTYATESTVLIRVDTSVGPGSEPDASTGRFSVRLESKTQYGPGLFLFDVRHTPYGCATWPALWLTDPNNWPTHGEIDIMEAVNQANSGNMVALHTTAGCDMSDIRRSMTGTAGQGDCHNATNSNTGCIVLATSPATYGPAFNAAGGGIVALEWRNEGIRVWVFSRNGAGAQGLTALPAAGETMLQGPDTQTWGPPLADFPATNCDMARHFRNQSIIVNIDLCGYLTEARWADSGCSKQKCTDFVANNPSAFTDAYWEFGGFQVYSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M4J6</accession>
    <name>A0AAJ0M4J6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_119781</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724602.1">
        <property type="nucleotide sequence ID" value="XM_062861610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M4J6"/>
    <dbReference type="GeneID" id="87880439"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="228"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="575"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="579"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="616"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="642"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="653"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3308822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="685" mass="74447" checksum="F9F7BABF5D65648F" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M4M2</accession>
    <name>A0AAJ0M4M2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Derlin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_525635</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the derlin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724676.1">
        <property type="nucleotide sequence ID" value="XM_062868860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M4M2"/>
    <dbReference type="GeneID" id="87887689"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007599">
        <property type="entry name" value="DER1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11009">
        <property type="entry name" value="DER1-LIKE PROTEIN, DERLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04511">
        <property type="entry name" value="DER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="225"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="231"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3308896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="260" mass="28857" checksum="1D2DE213F2E32CFC" modified="2024-07-24" version="1">MSSEIMDAYWAAPPMARTLATAILITSVSVYFGLLSTSWIYFTEDRLFRLPPEIWRLATSFLLSGPQLGILLDPYFAYQYLKQLETQNPKFPRKEDVLWYLMTVGGFIILINRTVLNGVFYLPGLIMALTYTATQDARGVKTSFFFFTVPAQTVPYCMLVASLLMSPGVIPLQISGIVSAHLHDFLTRLWPEFGGGWNLLPTPSLISRLVQTPRVFQREYGTAIRPPSAQASGSTTGAATGSVLPDSWKTRGTGRRLGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M4N3</accession>
    <name>A0AAJ0M4N3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase family C78-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_483270</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724440.1">
        <property type="nucleotide sequence ID" value="XM_062866150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M4N3"/>
    <dbReference type="GeneID" id="87884979"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019783">
        <property type="term" value="F:ubiquitin-like protein peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012462">
        <property type="entry name" value="UFSP1/2_DUB_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48153:SF4">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE MUG105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48153">
        <property type="entry name" value="UFM1-SPECIFIC PROTEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07910">
        <property type="entry name" value="Peptidase_C78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UFSP1/2/DUB catalytic" evidence="3">
        <location>
            <begin position="231"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="82"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3308660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="455" mass="51072" checksum="928C7D259F96BCA9" modified="2024-07-24" version="1">MGEGKPLVCPFCGWTNEAGEYEMLLHMETLHAEGESPCVVKEDWSPASIDTPEDTPYTECPVDGCGELLPLQELEYHMELHAEESSDDLQDESAPSTEPHATTKEAELLSSGPSRARREAEGNREPNHSSTSERQAKAISSWRQLLRMPGALTVNVFLPKSLTRDGKQAGVGSNTRSFTRGRRLGRAQLGKYAHEERMPDSLVNLLRKKGQVTAQDVIPVLAQLLEQSSSTKYAYLCHPCVQHVSKLKREGGFCGYRNIQMLASWIINTNSKGHEHFKGAIPSIFQIQEYIETAWDRGINAQGRVETGGIRGTRKYIGTPEALAVFALLGIPCECRAIDHREPGKSEAQLMEYVEEYFQSGVEDPTQRIRRTNLPPLYFQHAGHSMTIIGLEKLKNGSKQLLVFDPSFHDSSSILRLVGKKFVHPLPDLPLKLYRRGNRYLRAYREFELLRLVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M4X8</accession>
    <name>A0AAJ0M4X8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ORMDL family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_133204</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3309183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724963.1">
        <property type="nucleotide sequence ID" value="XM_062861768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M4X8"/>
    <dbReference type="GeneID" id="87880597"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007203">
        <property type="entry name" value="ORMDL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12665">
        <property type="entry name" value="ORMDL PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04061">
        <property type="entry name" value="ORMDL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018147">
        <property type="entry name" value="ORMDL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3309183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="180" mass="20682" checksum="87CFD3B14E28A8A4" modified="2024-07-24" version="1">MTDKTGRRRRSSSILQVYHEPPEPIEQLSDQSALPNLNANWVNAKGAWTIHFVLIICLKIFYDTIPGVSQETSWTLTNITYMFGSYIMFHHVRGVPFEFNGGAFDNLNMWEQIDDGAQYTPTKKFLLSVPIMLFLLSTHYTHYDMAYFTINFLAVLAVIIPKLPFSHRMRVGLFSGVPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M5G1</accession>
    <name>A0AAJ0M5G1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pescadillo homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Nucleolar protein 7 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">NOP7</name>
        <name evidence="8" type="ORF">B0T15DRAFT_515651</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the pescadillo family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M5G1"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17709">
        <property type="entry name" value="BRCT_pescadillo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000056">
        <property type="entry name" value="Pescadillo homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03028">
        <property type="entry name" value="Pescadillo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010613">
        <property type="entry name" value="PES"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12221">
        <property type="entry name" value="PESCADILLO - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12221:SF6">
        <property type="entry name" value="PESCADILLO HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06732">
        <property type="entry name" value="Pescadillo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="BRCT" evidence="7">
        <location>
            <begin position="361"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="312"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="485"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="320"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="332"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="353"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="505"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="594"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3309497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="666" mass="75389" checksum="763498BD8380DD4D" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M637</accession>
    <name>A0AAJ0M637_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription initiation factor IID, 31kD subunit-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_518621</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726253.1">
        <property type="nucleotide sequence ID" value="XM_062868377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M637"/>
    <dbReference type="GeneID" id="87887206"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07979">
        <property type="entry name" value="HFD_TAF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000069">
        <property type="entry name" value="Transcription initiation factor TFIID subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003162">
        <property type="entry name" value="TFIID-31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051431">
        <property type="entry name" value="TFIID_subunit_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068">
        <property type="entry name" value="TAF9 RNA POLYMERASE II, TATA BOX-BINDING PROTEIN (TBP)-ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068:SF4">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02291">
        <property type="entry name" value="TFIID-31kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="232"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="233"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="283"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3310473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="296" mass="30685" checksum="C36D96E9198645D6" modified="2024-07-24" version="1">MSATGAAAAQTNGAPAPSTSQSVSFSQQPQPAQSQANAPPSQIQPNSQLASQNQLQQQQQPTTTTATQSTTAPRPRDARTIELLLTAQGVTSFEQRVPLLLLDFAYRHTASILSDALHLSADPYTSHAGARPSAASGAAPVNVGEATISSNAVQLAIASRLGFQFRGGAGGGTGGTGGGGASKDWMMELAREKNKVALPRVLPSEWGVRLPSERFVLSGVSWGLRDVWAGQEGLEESSEEDEDQDDEMMVDGPGAGRAADAMDVETEDVGGDGVEGGTIGDVFGDEGMEDEDMTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M657</accession>
    <name>A0AAJ0M657_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA mismatch repair protein S5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_425660</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726090.1">
        <property type="nucleotide sequence ID" value="XM_062865636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M657"/>
    <dbReference type="GeneID" id="87884465"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061982">
        <property type="term" value="P:meiosis I cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03485">
        <property type="entry name" value="MutL_Trans_hPMS_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000017">
        <property type="entry name" value="PMS1 homolog 1, mismatch repair system component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF41">
        <property type="entry name" value="MISMATCH REPAIR PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="4">
        <location>
            <begin position="216"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="411"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="549"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="413"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="472"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="549"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="568"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="588"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3310310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="793" mass="86280" checksum="56B8E0222CF08009" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M669</accession>
    <name>A0AAJ0M669_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytoskeleton-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_42633</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726356.1">
        <property type="nucleotide sequence ID" value="XM_062865647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M669"/>
    <dbReference type="GeneID" id="87884476"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3310576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="337" mass="38798" checksum="F559B30E5EA99FCD" modified="2024-07-24" version="1">MGLLIRFIRDDRVLFGYLALNAVGWLWGVRILLRKWRDEAEIKPVQPKTQYITQETEDALKLGTLDTLLGHYNYSIRETAAKIVCDRAVNDRDAIEMLLWGITRQDYEERLKNLRALSIIIADAESLERLHTWKAYAALVRCLELSLDPKQDVLEAEGFDEYALRDITERVCLMYVSQLLSCYDAEKLVKAKFVEKWLAKQNWGITKEDRQRNFAQYMRCRGNHIADIVASIRACPSGQEALERAELVAPPSPTDSDPEDNAPLIERFKVLLPNNISVRNLSEDDPTALLIRSLQTVHSVEVEEQRMRHRHREAMVLNDGSRPVNSDDIIQRPDSPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M6R5</accession>
    <name>A0AAJ0M6R5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipase, GDSL-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_482063</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726657.1">
        <property type="nucleotide sequence ID" value="XM_062866072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M6R5"/>
    <dbReference type="GeneID" id="87884901"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01831">
        <property type="entry name" value="Endoglucanase_E_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037461">
        <property type="entry name" value="CtCE2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052762">
        <property type="entry name" value="PCW_deacetylase/CE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37834:SF2">
        <property type="entry name" value="ESTERASE, SGNH HYDROLASE-TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37834">
        <property type="entry name" value="GDSL-LIKE LIPASE/ACYLHYDROLASE DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G00620)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042572484" evidence="1">
        <location>
            <begin position="21"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="2">
        <location>
            <begin position="174"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3310877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="433" mass="48201" checksum="BC964BD8B8CEBCDB" modified="2024-07-24" version="1">MVSLSSMAVFGLALLSRVSATILQNGQVRATSFPDTRIDPSAYSFRTYPANASEISYKGRWDSKYVSWWSGPGIKFGYTGQTVAISFGNLTSNGVLVGYRIGGLDWMFTNITAGATHILVSPDTPGSNLTGPVNPWTFELRVTNWAYGVQIDAVHVAAGARLIRIPDYDRRIEVIGDSLAAGMYTSYEGLSSWAYGLGAGLGNTEYSVTAYPGICAADQDCWGNPRGQVHQWFYTSDTSYRASVMYGDDPEPWDFKKHPAADIVVINIGTNDQNKENSVTTEAYIDALTKIIQGVHGKYPKAHVIVMSLWLGFYQSGNTYLPNAPQGFVKEIHQMVEWFNSDAYLRNPIVYDGVTKMRSRTGRKTKPFVHYFNTTGILQHNDIAPQWHPTDVGAIKVASHLQQFIRMTFGWDFHATGPEVFHETLYWNDEPSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M6Y7</accession>
    <name>A0AAJ0M6Y7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Eukaryotic translation initiation factor 1A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 4C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_387796</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the eIF-1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727138.1">
        <property type="nucleotide sequence ID" value="XM_062864407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M6Y7"/>
    <dbReference type="GeneID" id="87883236"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05793">
        <property type="entry name" value="S1_IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000071">
        <property type="entry name" value="Eukaryotic translation initiation factor 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00216">
        <property type="entry name" value="aIF_1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001253">
        <property type="entry name" value="TIF_eIF-1A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00523">
        <property type="entry name" value="eIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21668">
        <property type="entry name" value="EIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00652">
        <property type="entry name" value="eIF1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1-like" evidence="10">
        <location>
            <begin position="22"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="114"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3311358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="158" mass="17844" checksum="B40E41C5B3AC9142" modified="2024-07-24" version="1">MPKNKGKGGKNRRRGKNENDNEKRELTFKEEGQEYAQVVKMLGNGRLEAMCFDGVKRLGLIRGKLRKKIWINNGDIILVSLREYQDNKGDVILKYSADEARSLKAYGELPDHAKINETDTFGPNEDGDCGFEFDEDRDSEAEEDGAADGKKEISIDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M788</accession>
    <name>A0AAJ0M788_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase family 55 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_405903</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727421.1">
        <property type="nucleotide sequence ID" value="XM_062865305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M788"/>
    <dbReference type="GeneID" id="87884134"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23668">
        <property type="entry name" value="GH55_beta13glucanase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039279">
        <property type="entry name" value="QRT3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="RHGA/B-epi-like_pectate_lyase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928:SF2">
        <property type="entry name" value="PECTATE LYASE SUPERFAMILY PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928">
        <property type="entry name" value="POLYGALACTURONASE QRT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pect-lyase_RHGA_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042549990" evidence="1">
        <location>
            <begin position="18"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="2">
        <location>
            <begin position="41"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3311641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="802" mass="86190" checksum="568829EC5FB92499" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GKI7</accession>
    <name>A0AAJ0GKI7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Autophagy-related protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">B0T15DRAFT_316830</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer. Forms a ternary complex with ATG13 and ATG17.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Preautophagosomal structure membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717368.1">
        <property type="nucleotide sequence ID" value="XM_062864003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GKI7"/>
    <dbReference type="GeneID" id="87882832"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="STKc_ATG1_ULK_like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000817">
        <property type="entry name" value="Serine/threonine-protein kinase ATG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048941">
        <property type="entry name" value="ATG1-like_MIT2"/>
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    <dbReference type="InterPro" id="IPR022708">
        <property type="entry name" value="Atg1-like_tMIT"/>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF22">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12063">
        <property type="entry name" value="ATG1-like_MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATG1-like_MIT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="22"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="338"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="522"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="792"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="876"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="932"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="536"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="560"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="570"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="799"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="932"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00060750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAK3301588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="959" mass="105302" checksum="A664B80220BEE0C0" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GKW9</accession>
    <name>A0AAJ0GKW9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_323480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717562.1">
        <property type="nucleotide sequence ID" value="XM_062864077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GKW9"/>
    <dbReference type="GeneID" id="87882906"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3301782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="464" mass="50043" checksum="452A41AC0A936861" modified="2024-07-24" version="1">MADMGLQLEPISQGLEQYGPWHFADVRFQQDHRAELQAALLQTAAISELSDTLREISKAGRADCHSSSRPEVTLSVLREPEPTAEKSSRRSSPGGCTSDAATNEIGRSLFPRILHPSLGFRQVVPSGEDVVTFPFSAPPSRPGSFLKRRRPATDVDGPGTYSLSRKKRRLLRHLITSRLSQPFSLPATHILNRESVATGDKRFIKLAAIMSARRGFNSTVTTQPHSPLPQPQQPSPSTWLRRAAVLNSLRSRVRAEVVERGHVQVSDLAAKAAVFQQGHGNSVFVGGRYLITMTTPSVAAPMTPGPRGVSQPSSSGCPPPTLPPPPPPPPGSLQSPPGLRLQPGSIHVPMAGGPPPTCATTCLRIPSPKLRPLRSPELRVTRPLVPLEDIEELDGDDDGGGGVAFPTSEHESRYEDEPSDEVYADFSVIFGGADGEDSDEEGGGGDHFEDYMDDLDGIPWNARC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GL30</accession>
    <name>A0AAJ0GL30_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_286429</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays an important role in cellulose degradation. Shows hydrolytic activity against several glycosidic compounds.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3"/>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3301914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717694.1">
        <property type="nucleotide sequence ID" value="XM_062863642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GL30"/>
    <dbReference type="GeneID" id="87882471"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080079">
        <property type="term" value="F:cellobiose glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000011">
        <property type="entry name" value="Cytosolic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="GH_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF36">
        <property type="entry name" value="LP05116P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00056775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3301914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="476" mass="54137" checksum="D50BD62117B48657" modified="2024-07-24" version="1">MSLPKGFKWGFATASYQIEGSTTEDGRGPSIWDTFCAIPGKIADGSSGAVACDSYKRTKEDIDLLKSLGATAYRFSISWSRIIPLGGRNDPINQKGIDHYVKFVDDLLEAGIEPFITLFHWDLPDALDKRYGGFLNKEEFSADFENYARVLFKAIPKCKHWITFNEPWCSSILGYNSGYFAPGHTSDRSKSPVGDSAREPWIVGHNILIAHGKAVKCYREEFKPTQGGEIGITLNGDATLPWDPEDPLDVEACDRKIEFAISWFADPIYFGHYPESMRKQLGDRLPTFTPEEVALVKGSNDFYGMNHYTANYIKHKKGVPPEDDFLGNLETLFYNKNGDCIGPETQSFWLRPHPQGFRDLLNWLSKRYGYPKIYVTENGTSLKGENDMSLEQIVEDDFRVRYFHDYVHAMALAHAEDGVNVQGYMAWSLMDNFEWAEGYETRFGVTYVDYANDQKRYPKKSAKSLKPLFDSLIKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GL46</accession>
    <name>A0AAJ0GL46_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_487191</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3301943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717723.1">
        <property type="nucleotide sequence ID" value="XM_062866419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GL46"/>
    <dbReference type="GeneID" id="87885248"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000165">
        <property type="term" value="P:MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000294">
        <property type="entry name" value="Map kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000263">
        <property type="entry name" value="MAP kinase skh1/pek1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050915">
        <property type="entry name" value="MAP_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448:SF5">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINAE MKK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="177"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3301943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="478" mass="51695" checksum="F0F0336BAE4D528E" modified="2024-07-24" version="1">MGGPRPGGRAGPRLGLAIPPSANVKPVGNQGAPPPRPALPTLNIATPMGSTVVPQEQPHKALSLQSASGGSESSAAHSRSGSFGPLDGRASNPTSAGSQFSALSFASHYGIGSTRQTGDPVSAVGSLYSNASESIGEEGSLHGLESFDKLSLEKARTADVEDLDDEGWRIVSMEKRIIELGTLGEGAGGAVTKCKLKGGNTMFALKIITTNPDPDAKRQIIRELGFNKECASQHICRYYGAFVDPATATISIAMEFCEGGSLDSIYKEVKRLGGRTGEKVLGKIAEGVLQGLTYLHSKKIIHRDIKPSNILLCRNGDVKLCDFGVSGEFGTKGDASTFIGTSYYMAPERITGQSYTITSDVWSTGITLLEVAQHRFPFPVDGTEMQPRAGPLDLLTYIVKHPTPKLKDEPDANIFWSGNFKYFIDCCLEKEPSRRATPWRMMEHPWMKEMSTKRVNMRRYLSQVWGWDDQEPQAPQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GLD1</accession>
    <name>A0AAJ0GLD1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_403224</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717802.1">
        <property type="nucleotide sequence ID" value="XM_062865194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GLD1"/>
    <dbReference type="GeneID" id="87884023"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF9">
        <property type="entry name" value="TAH-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="492"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="260"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3302022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="752" mass="82937" checksum="8A2E0D7703446B7E" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GLD2</accession>
    <name>A0AAJ0GLD2_9PEZI</name>
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        <recommendedName>
            <fullName evidence="3">Signal peptidase complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_290717</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Dispensable for SPC enzymatic activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPCS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717860.1">
        <property type="nucleotide sequence ID" value="XM_062863709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GLD2"/>
    <dbReference type="GeneID" id="87882538"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009542">
        <property type="entry name" value="Spc1/SPCS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13202">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 12 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13202:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06645">
        <property type="entry name" value="SPC12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3302080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="102" mass="11268" checksum="E5E3B20AB31293F6" modified="2024-07-24" version="1">MADQILDQVRDLFEGQIDFEGQKLAELLVNVALTVVGVVAYLVGYFLQDIKLALYITLAGTAATFVLVVPPWPFFNRHPVKWLPVGGITPPANLVVDDKAFR</sequence>
</entry>
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        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 5">
            <text>4-nitrophenyl phosphate + H2O = 4-nitrophenol + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21664"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57917"/>
            <dbReference type="ChEBI" id="CHEBI:61146"/>
            <dbReference type="EC" id="3.1.3.41"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Divalent metal ions. Mg(2+) is the most effective.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.41" evidence="3 5"/>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717835.1">
        <property type="nucleotide sequence ID" value="XM_062869891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GLF8"/>
    <dbReference type="GeneID" id="87888720"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008967">
        <property type="term" value="F:phosphoglycolate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000039">
        <property type="entry name" value="Phosphoglycolate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006349">
        <property type="entry name" value="PGP_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01452">
        <property type="entry name" value="PGP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288">
        <property type="entry name" value="4-NITROPHENYLPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288:SF46">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000915">
        <property type="entry name" value="PGP-type_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="27"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="29"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00050247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00066659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00069197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3302055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="310" mass="33894" checksum="47BA7D4D73E7F349" modified="2024-07-24" version="1">MSTPKYLTGDVAAINEFIDQFDVFLLDCDGVIWSGDHVFEGIPQTLELLRSRGKKVVFVTNNSTKSRQEYVKKFTALGIPSEAEEIFGSAYSSAIYISRILKLAPPKNKVFVIGEAGIENELRSENIPFIGGTDPAFRRDMTPEDWKGIADGTLLDPDVGCVLAGLDFHINYLKLSHALQYLRRGAVFLATNIDSTFPMNHNFFPGAGSMSMPLAYMTGQQPLALGKPSQAMMHAIEGKFQLNRERTCMVGDRLNTDIKFGIEGRLGGTLAVLTGVSQQADWEAADAVAVPAFYVDKLSDLGAAARVDTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GM43</accession>
    <name>A0AAJ0GM43_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SNF5-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_305886</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718232.1">
        <property type="nucleotide sequence ID" value="XM_062863866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GM43"/>
    <dbReference type="GeneID" id="87882695"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006939">
        <property type="entry name" value="SNF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10019">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04855">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="383"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="442"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="559"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="383"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="460"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="511"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="617"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3302452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="747" mass="82578" checksum="0AD29173D678C9BC" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GMB6</accession>
    <name>A0AAJ0GMB6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_497038</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718358.1">
        <property type="nucleotide sequence ID" value="XM_062867237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GMB6"/>
    <dbReference type="GeneID" id="87886066"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3302578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="75" mass="8534" checksum="796D385C31A5CD54" modified="2024-07-24" version="1">MDPHEAAEKMLHCRYTVDDCKAGKAFGEYAQTMLKYATRLAWLMIRLIPKEALGFASATPAQNRVVDWIAFMRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GMD6</accession>
    <name>A0AAJ0GMD6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_514642</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718401.1">
        <property type="nucleotide sequence ID" value="XM_062868137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GMD6"/>
    <dbReference type="GeneID" id="87886966"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3302621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="311" mass="33978" checksum="7780384831DA976D" modified="2024-07-24" version="1">MPIPIPVLLPIPVLLPIPSQAKAAYAHSQRHPQEPQPLGAFLDAANKRTRLLFLPSDPEFFELKHAAVKGHQSLASKWKDILWEVDKDKSIRSLRVLAVSQSIYNVAYDAIIRGASTTALLTFRVYFDPSSNNDVSLLNTSTSTILVVSRSQPDDPGHQEIRVYHLAQIGPGQGAGLPVNIRTLSAVRNQGVNTATLHPLIDLRAGRTIELIGSRPEEKYLVTRIENLSDSRSSSVWRAMISILTPDHLSVVAKVLKSTGSAKSAATIWLRKTNIHSKLGAGGLPTIMQLLGLDARIYSLYLKDIATPSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GMG1</accession>
    <name>A0AAJ0GMG1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_505673</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718458.1">
        <property type="nucleotide sequence ID" value="XM_062867535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GMG1"/>
    <dbReference type="GeneID" id="87886364"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060261">
        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000066">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000026">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051370">
        <property type="entry name" value="PPIase_Pin1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10657">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10657:SF4">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00639">
        <property type="entry name" value="Rotamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="WW" evidence="6">
        <location>
            <begin position="7"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="PpiC" evidence="7">
        <location>
            <begin position="71"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3302678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="182" mass="20524" checksum="7096BDA6C0CB11BF" modified="2024-07-24" version="1">MADQPETGLPPNWEVRHSQSKNLPYYFNAVEKVSRWEPPPETDTEKLKIYMATYHSNKGGLAAGSGEERQPGKIRAAHLLVKHRDSRRPSSWRENTITRSKEEAYDMIRAHERRIQSGEISLGQLALTESDCVSARKQGDLGYFGRGDMQKEFEDAAFALKPGEISGIVETASGLHLIERLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GNH5</accession>
    <name>A0AAJ0GNH5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA polymerase II transcription factor B subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_539456</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the TFB2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718969.1">
        <property type="nucleotide sequence ID" value="XM_062869734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GNH5"/>
    <dbReference type="GeneID" id="87888563"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2610:FF:000001">
        <property type="entry name" value="General transcription factor IIH subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040662">
        <property type="entry name" value="Tfb2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004598">
        <property type="entry name" value="TFIIH_p52/Tfb2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00625">
        <property type="entry name" value="tfb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13152:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13152">
        <property type="entry name" value="TFIIH, POLYPEPTIDE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03849">
        <property type="entry name" value="Tfb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18307">
        <property type="entry name" value="Tfb2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor Tfb2 C-terminal" evidence="10">
        <location>
            <begin position="433"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3303189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="504" mass="55882" checksum="C93DA710CC120CBF" modified="2024-07-24" version="1">MSVAPQSYQLSDYLEKLPGTTFRKLYQQPSTAFAIFRRMLPPLAKVFVQALLYMPSPLLLSELDVWVRPEGKMHRDRALSILRSLHIIQITPPGRDKPQEIQLTTNFKNSLRLALEGGGTHNSFGVPSKLPVDPKIDIAYLDNYARKKWEDILHYVVNSVPVHGDAGGGASGGGPKASVKELLLAGRLVERRPNTRGGVGITQAGFTFLLQEANAQVWTLLLLWLEAADHTKAAAGDAKGPTKPDSIDMLSFLFMLASLELGRAYDTDALTETRRNMLPALVDFGLIYIPREDPRQYLPTRLATTLTSSASALRSVSSGFSAATANNPGDASSLGIAPEATSKGSIIIETNYRLYAYTSSPLQIAVLALFTQLNMRFAGMVTGRLTRDSIRRAIGFGITADQIIRYLASHAHEQMVRAAAATGRPVLPPTVVDQIRLWQLENERMRTTAGFLFKDFDSVEEYLSLSEYAEEIGVLVWKSDRKRMFFASKFEQLRDYLKSRKKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GNR1</accession>
    <name>A0AAJ0GNR1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Fumarylacetoacetase</fullName>
            <ecNumber evidence="3 13">3.7.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Fumarylacetoacetate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0T15DRAFT_402140</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10244"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18034"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="3.7.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the FAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.2" evidence="3 13"/>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718925.1">
        <property type="nucleotide sequence ID" value="XM_062865142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GNR1"/>
    <dbReference type="GeneID" id="87883971"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004334">
        <property type="term" value="F:fumarylacetoacetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902000">
        <property type="term" value="P:homogentisate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000009">
        <property type="entry name" value="Fumarylacetoacetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.230">
        <property type="entry name" value="Fumarylacetoacetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005959">
        <property type="entry name" value="Fumarylacetoacetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015377">
        <property type="entry name" value="Fumarylacetoacetase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036462">
        <property type="entry name" value="Fumarylacetoacetase_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01266">
        <property type="entry name" value="fum_ac_acetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069">
        <property type="entry name" value="FUMARYLACETOACETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069:SF2">
        <property type="entry name" value="FUMARYLACETOACETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09298">
        <property type="entry name" value="FAA_hydrolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63433">
        <property type="entry name" value="Fumarylacetoacetate hydrolase, FAH, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 13" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Fumarylacetoacetase N-terminal" evidence="15">
        <location>
            <begin position="18"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="14">
        <location>
            <begin position="144"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU366008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF09298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3303145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="433" mass="47198" checksum="866B5100C4D0AB29" modified="2024-07-24" version="1">MASSWVPDIDPCSDFSLANIPFGIISTADDRSPHAGVAIGSYVLDLKVLAANTDLTAVFPGINGLTETFSQPTLNAFARLGRAVHRQVRAGIQDLLSADTTQPSILRDNPDLRQKALLPQRAVKMHMPMEIGDYTDFYAGYHHAYAVGVMFRGPQNALQPNYLHMPVGYHGRASSVVVSGTPIHRPVGQILLDPSQAGPKQPVTAPSRKLDIELELGCFIARGNEIGRGISVGEAEEYIFGYVLLNDWSARDIQMWEYVPLGPFNGKNFATTISPWVVLADALEPFRARAIENKTELQAYLEEKREDNVFDIKLEVDLTTAEGDTTTIGRTSSKHLIWSFPQMIAHHTLGGCPMRTGDLLGSGTISGPGGAGERGSLLEMTENGKREVLLYGMDMRTFLKDGDTVTLRGFCGPEGGRVGFGECRGRIYSSLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GP27</accession>
    <name>A0AAJ0GP27_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nitronate monooxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_568919</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719050.1">
        <property type="nucleotide sequence ID" value="XM_062870786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GP27"/>
    <dbReference type="GeneID" id="87889615"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF28">
        <property type="entry name" value="DIOXYGENASE FAMILY OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G09600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3303270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="330" mass="35729" checksum="F2B48AA261A491E3" modified="2024-07-24" version="1">MPFNTELTRRLGITVPVVQGGMQHVGTAEMASAVSNAGGLGIITALIWPEPEGLRQEIRKCRKLTSKPFGVNITLLPALVPPDYGAYAQVVIDEGVKIVETAGNSPGPVISKLKKAGCIILHKCTTIRHAQSAVKLGVDFLSIDGFECAGHVGESDITNFILLSKARQTLKVPFIASGGFADGQGLAAALCLGACGINMGTRFLCTVESPIHHNIKEQIVKAEETDTALVLRRWRNTTRLYRNKVTEQALKVEQESKTGEFSEIAPYVSGKRGREVFINGDPEYGVWTAGQVIGLIHDIPTCKELVARIEKEAEETLRERLGLFTPSSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GP80</accession>
    <name>A0AAJ0GP80_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_280650</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719393.1">
        <property type="nucleotide sequence ID" value="XM_062863573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GP80"/>
    <dbReference type="GeneID" id="87882402"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004574">
        <property type="entry name" value="Alkb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16557">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16557:SF2">
        <property type="entry name" value="NUCLEIC ACID DIOXYGENASE ALKBH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="7">
        <location>
            <begin position="218"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="274"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604574-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3303613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="394" mass="44970" checksum="6C43D0BF152A05E3" modified="2024-07-24" version="1">MTVDIKHLDAHEQPSDELRAKWKTFSKAEPKDLLNSSDIDDLEDPESATEFSLAGSIPIDTLNTSFRHICPNNGAEFKATKDAPIYYHPLLPGLLVVPSLVPPSVQKALLRHLIHRDLSQPHHQTNLHLHFNLPYPTSEDPSFFSYPPSSAVTFAPKDPSVHKPLSIKQVLERKLHWVTLGGQYDWTNRVYPEDGGPAMPAFPADVARFLETLFPETKAQAAIVNFYTPGDTMMMHRDVSEETDKGLVSLSLGCEAFFMIAPNEGDVDADAAGLEERREHRPDAESGEKEKEEKKKEGEKKEGEKKEEKDEEKKEKKEKKEEKKKEFLLLRLRSGDAIYMTKESRVAWHGVPKVLKGTCPEYLEDWPAEDGKYEDWRGWMRSKRINLNVRQMRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GPE0</accession>
    <name>A0AAJ0GPE0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NmrA-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_540904</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719436.1">
        <property type="nucleotide sequence ID" value="XM_062869818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GPE0"/>
    <dbReference type="GeneID" id="87888647"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051604">
        <property type="entry name" value="Ergot_Alk_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43162">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43162:SF1">
        <property type="entry name" value="PRESTALK A DIFFERENTIATION PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3303656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="320" mass="33816" checksum="311FECF2318D687A" modified="2024-07-24" version="1">MASPKVIVFGPTGGVGSAAALTAQQCGAQVVLAMRDTHKPIPGLTPEQERAGGFERVQADLTKPETVQAAVVQTGAKRAFIYVAIGAPDHMRAAITALKAGGVEFVVILSSCSVQGQGDDLRRYTPAEFINWQHAQVELVLEEVFGTDRFATIRPGYFASNFFGFKKAIAAGGTVKIPYPEAKFDYIAPEDIGRVSGTVLAGGPQAVAAAGGKHIIYLAGPQLVPQGDVLVMIGKALGKDLKVEGFADDEEAVKFLVSVQGTPEPVAKQLVRGYKATAEGQDVFPAGTLEEAVANSEKYGRKPGTKIQDWVETNKDRFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GPI5</accession>
    <name>A0AAJ0GPI5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_513886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719527.1">
        <property type="nucleotide sequence ID" value="XM_062868075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GPI5"/>
    <dbReference type="GeneID" id="87886904"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3303747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="266" mass="29926" checksum="D7EC812A01333181" modified="2024-07-24" version="1">MPRHSLQQMRRSRTRLVYDLLEEHELEEPQQERDHDPECILPSAHDDRRFFRCMTWLGLLACLGFTGVAIGVIVKFLADGSKLGLDVASADFALNKNSGFQECRAREPPTDPATCPDVLANLLSPAWDNRRGMASEFNDVTNYYFVSKNRTRTPGGQPVVYDWCEAVSCLDSTFTVVPSIPRGAAFGATSLSTWCSITVTLFTAVWGYESLERRRGKERACRALGDVAWYDCHGYNLCSFAWWWVSFASYVVGRAYKLPPGLSAGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GPV7</accession>
    <name>A0AAJ0GPV7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Maleylacetate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_223279</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3303876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719656.1">
        <property type="nucleotide sequence ID" value="XM_062862840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GPV7"/>
    <dbReference type="GeneID" id="87881669"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08192">
        <property type="entry name" value="MAR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056798">
        <property type="entry name" value="ADH_Fe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018211">
        <property type="entry name" value="ADH_Fe_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496:SF97">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE IRON-TYPE_GLYCEROL DEHYDROGENASE GLDA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25137">
        <property type="entry name" value="ADH_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00060">
        <property type="entry name" value="ADH_IRON_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA" evidence="2">
        <location>
            <begin position="30"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-containing alcohol dehydrogenase-like C-terminal" evidence="3">
        <location>
            <begin position="196"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3303876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="401" mass="42510" checksum="66B44E6945F123EF" modified="2024-07-24" version="1">MSHGSRLVPCSDGSPLFGAWMPHAHLKQLYYGPSCVEQHLLRTLPCPGSRVFIVTSQSLATKTPLIRQLETLLGEHHAGTFAGIRQHGEAVGVDQAFAAVVSAHPAIDTILSVGGGSAIDAAKVVSFRISQQRGGVFLTHLAIPTTLSAAECTPGGGFTRPDGTKEGFMAAGMGVSAIFYDPAFARYTPRRLLLGSGMRAVDHAVESVYHPNASLVPWKAMACWALGVLFQYLPQVADHFDNDPQQHGGGMDDDALTMLMLASFASSGFRGTNFAGGMGLSHSLGHALGSPYGIPHGETSCLTLAPVIRLLASERPPAASQISRFLLPAIGRQPTGDAVHDSADFAASLDELVLRLGLQQPSLSDRGVGRDQIPIIVERAVKGPEEKELRAAVRRLVEALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GPW8</accession>
    <name>A0AAJ0GPW8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein-ribulosamine 3-kinase</fullName>
            <ecNumber evidence="1">2.7.1.172</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_535121</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>N(6)-D-ribulosyl-L-lysyl-[protein] + ATP = N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48432"/>
            <dbReference type="Rhea" id="RHEA-COMP:12103"/>
            <dbReference type="Rhea" id="RHEA-COMP:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:90418"/>
            <dbReference type="ChEBI" id="CHEBI:90420"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.172"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:48433"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fructosamine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.172" evidence="1"/>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3303959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719739.1">
        <property type="nucleotide sequence ID" value="XM_062869480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GPW8"/>
    <dbReference type="GeneID" id="87888309"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102193">
        <property type="term" value="F:protein-ribulosamine 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1200.10:FF:000018">
        <property type="entry name" value="Fructosamine-3-kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016477">
        <property type="entry name" value="Fructo-/Ketosamine-3-kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149">
        <property type="entry name" value="FRUCTOSAMINE 3 KINASE-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149:SF8">
        <property type="entry name" value="PROTEIN-RIBULOSAMINE 3-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03881">
        <property type="entry name" value="Fructosamin_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006221">
        <property type="entry name" value="Ketosamine-3-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00048655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR006221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3303959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="327" mass="35105" checksum="B50E5E27D5DDE374" modified="2024-07-24" version="1">MPPNVDPAILEALGLEATSSKLIPHGGSGFSSTFKLVATKDGEDIAYFVKTKSGPDAEIMFRGEHASLNAIHAVDPTLCPRSYAHGAMRSSPGEFFLVTDFLNLGTSATTGGGGGGTGLSLAAKLAKLHTTPAPIPKGLSKPMFGFPVPTCCGATKQDNAWTESWAEFYAEHRLRAILREGVRNNGRNKELAEAVETVAGMVVPRLLGDGHLKGAVPVVVHGDLWSGNHGRGTIAGKGGVEEVVFDPACVYGHSEYELGIMRMFGGFGRGFWQEYEALVPNAEPKEEWEDRIALYELYHHLNHYALFGGGYRAGAMSIMRRLIAKYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQA8</accession>
    <name>A0AAJ0GQA8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_398996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719944.1">
        <property type="nucleotide sequence ID" value="XM_062864984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQA8"/>
    <dbReference type="GeneID" id="87883813"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022025">
        <property type="entry name" value="Amidoligase_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36847">
        <property type="entry name" value="AMIDOLIGASE ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36847:SF1">
        <property type="entry name" value="AMIDOLIGASE ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12224">
        <property type="entry name" value="Amidoligase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="416"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="482"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3304164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="510" mass="57044" checksum="59FADD41D81CE0A9" modified="2024-07-24" version="1">MASSRSARAAPSAGPAYRPYFGVEIEIFVKLRDGLEQRLKDIHHDRYNGRAYQNLPAYYQQWNFTLSNAADNGSREIAEQKAKQRLCVGLAVEHLIKEVLGKNNGWACKPDASLREFEIKDAESRWKWWGIEIVSPAMSTSRPWRTEIESVFKAVGKEFEFWTHECCSTHVHVSPGPDKKTKYRLSDLVDKAKGAYLWEEALCELIEPKRRKSVWARPNHKVYAGLEYANVANYGWKVVFDELENAAMDGTERFLNRMRGGPVGTSDCTRYVSTSFHPTDRLGTVELRRQAGSASATTVIYRVLFAVTLHVSGLSYPYAKASDRRDHPTAQELIAELSYCMGQLPKTCSSTSFINWLRWCVARYAGGYQPSELETNVHEMKLRLGAVYPNVNLPARTRPQGPSIPDATSRDSPSGSRTITRPAPTPTHAASPPPSRPVAGIVRYDLPERPAPRRDSRDGRARSPPPPATQGRRAVSRPPPGSSSRAAPEARAQLIALDETRAGRSRRPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQN8</accession>
    <name>A0AAJ0GQN8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_239369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720158.1">
        <property type="nucleotide sequence ID" value="XM_062863048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQN8"/>
    <dbReference type="GeneID" id="87881877"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007175">
        <property type="entry name" value="Rpr2/Snm1/Rpp21"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04032">
        <property type="entry name" value="Rpr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3304378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="206" mass="21789" checksum="EA64EC92932C8811" modified="2024-07-24" version="1">MASNEGTATLRFLTDAGHLLAGTAPETSADLMRRRNELMFEHEMPLSDRQRQNVCGCCGHIMVLGLGSELQVEAGKRTGKKPRSARGLKVNKARGNTLQTRPGPTKAITCGHCGRFTKVELPAPAPITRHKVKAGKIPEPSGPGVNLSLSSASREPPSQKSSANASSKKRAKSRKAGLQALLSQSNAARNAGPGLGLSLADFMQKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQR1</accession>
    <name>A0AAJ0GQR1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_494653</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719950.1">
        <property type="nucleotide sequence ID" value="XM_062867024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQR1"/>
    <dbReference type="GeneID" id="87885853"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000149">
        <property type="entry name" value="MFS transporter, SP family, general alpha glucoside:H+ symporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF76">
        <property type="entry name" value="MALTOSE PERMEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G07240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="412"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="450"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="480"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="64"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3304170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="564" mass="62622" checksum="50D1B76081063F91" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQT8</accession>
    <name>A0AAJ0GQT8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EKC/KEOPS complex subunit GON7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0T15DRAFT_535803</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. GON7 likely plays a supporting role to the catalytic subunit KAE1 in the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GON7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719990.1">
        <property type="nucleotide sequence ID" value="XM_062869523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQT8"/>
    <dbReference type="GeneID" id="87888352"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014849">
        <property type="entry name" value="EKC/KEOPS_Gon7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08738">
        <property type="entry name" value="Gon7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0779">Telomere</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="65"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3304210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="105" mass="11622" checksum="06ABB0DA163E501F" modified="2024-07-24" version="1">MTSSQSQPTLSANYTSTGNASFTIHHPLTAPPSSTTVENKIASLAELRRSIIVLQNQINQELTARMEEDQARNSSATKANGVKKIIDDEKEEENYGEEVQDEEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GR73</accession>
    <name>A0AAJ0GR73_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-CH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_512729</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720376.1">
        <property type="nucleotide sequence ID" value="XM_062868002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GR73"/>
    <dbReference type="GeneID" id="87886831"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16495">
        <property type="entry name" value="RING_CH-C4HC3_MARCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46347">
        <property type="entry name" value="RING/FYVE/PHD ZINC FINGER SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46347:SF1">
        <property type="entry name" value="RING_FYVE_PHD ZINC FINGER SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="6">
        <location>
            <begin position="50"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="297"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="300"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3304596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="327" mass="36972" checksum="46DE5A7A73167DD6" modified="2024-07-24" version="1">MASGSFQSQWAFPSGMDSQNDGDRSGGQQPRDAASTSEASSQGPTPTQRQRHYKPRTCRICLEVVNPTTELDDSLAGRLFSSKARVYYVSEDPELGRLISPCKCKGSQRYVHEGCLRAWRNAAPLSDRNYWRCPTCHFEYRLQRLRWGRWISSKLLRGILTFFIMVATIFVLGFIADPIINFWVDPFGTVAETLLTGLKFDEPIVVDDEAGWSAHFMKGFLSLGLLGFLKTMFVMSPWNWFNIRVGGRGRRRGTGRDRMEQVNWALVVIGVITFLGATWKFVNHLTAKTLEMASDRVVDVQEDTPDDDEEDDIPDAGAGPQESRKDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GRG6</accession>
    <name>A0AAJ0GRG6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_398840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720526.1">
        <property type="nucleotide sequence ID" value="XM_062864975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GRG6"/>
    <dbReference type="GeneID" id="87883804"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="67"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3304746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="233" mass="25944" checksum="BEEA8BAF111636F4" modified="2024-07-24" version="1">MMLRLATEADLEAMTAVLVWASPLDPVYPYRFPDRELYPDEFAALCRRKCAEYLETSTVVVCEMPVDPYRSETQVVAFSAWDMPSAAQPERSRRASAVGNLTRQSAFRTALAHHKSTLFDSRYRPQGGHVFLKILLCHPSYQRRGAGTALTSWGIEQARRLGVHTTVFASPMGLRLYKKLGFREVGTFRVQPEGDREYLEIPALALGPGYVGGMREAAWFGGGGVPHLESVCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GRM6</accession>
    <name>A0AAJ0GRM6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Azaphilone pigments biosynthesis cluster protein L N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_253682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720607.1">
        <property type="nucleotide sequence ID" value="XM_062863222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GRM6"/>
    <dbReference type="GeneID" id="87882051"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031348">
        <property type="entry name" value="PigL_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17111">
        <property type="entry name" value="PigL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Azaphilone pigments biosynthesis cluster protein L N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3304827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="155" mass="17032" checksum="C25C3D80DECF1DBB" modified="2024-07-24" version="1">MDPLSVTAAVVGIAAPTAHCIRLLIDDIQKIVDAPETINSLRKDLLSIDQALASVRAISDTQWKSLGETVVSQLKAATTLCRESCNKFRADLSRWTRHSEDGKLSLRDRAMVGFLKQGSVKSISEQLQQCNITLTSVVCIATLYSSLQQMQVTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GRQ8</accession>
    <name>A0AAJ0GRQ8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_371683</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720694.1">
        <property type="nucleotide sequence ID" value="XM_062864205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GRQ8"/>
    <dbReference type="GeneID" id="87883034"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF16">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3304914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="188" mass="21671" checksum="00A71CE8EC4C2FBB" modified="2024-07-24" version="1" fragment="single">VIIVIDALDECNPATRRQFLNAIESILRDSSSLVKIFVSSRDDQDIVYKLQEYPNLELSSDRNQDDIAKFVESETNSMIKSGAMLRYSTSKEELRQRIIEEVTKGAHGAERRGRFRWAALQLQALCDLSSDAAVRERIGRLPPTLEDLYRESLEKLDNYQAEADRKYARRIIGWLLCARRNSARTNFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GS57</accession>
    <name>A0AAJ0GS57_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_484840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720901.1">
        <property type="nucleotide sequence ID" value="XM_062866249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GS57"/>
    <dbReference type="GeneID" id="87885078"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF55">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="186"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3305121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="269" mass="31027" checksum="EE9A36DAC46D5895" modified="2024-07-24" version="1">MQKSYQVCGWVKVWRIAPEILRPDFTWPLQRLGDRPLASRITPCPPPLAPGLLLWLRIIGRCHAFLQDFSRYYCAWFGFPHNHAMSALPFGLLLKWSDGTSLDEVNATRAVRAAGIPAPKVISCGLGDVQDFLEEEEKETVERELGVILEIMRSWPNPVGPKQDLRRRSLTGHSLQGRKMEELKHTIVFSHGDFYMHKILVHEGHVSGLIDWETAGWYPEYWEFTTPLRWASLLHEWRGMLLRLGGDKYARELEAEQAIGKLTVDSWIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GS95</accession>
    <name>A0AAJ0GS95_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_531552</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720961.1">
        <property type="nucleotide sequence ID" value="XM_062869254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GS95"/>
    <dbReference type="GeneID" id="87888083"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3305181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="91" mass="10687" checksum="DAB9B51A1532EB57" modified="2024-07-24" version="1">MTSTKGVHFHVGASDESKDLTYIHWSVFGGYANFRRPEQMQLEPWIIPYYHSSSCGVRSGVVCYQLSHKFTFPTSHDEWEHYQRENLEFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GSD7</accession>
    <name>A0AAJ0GSD7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Aquaporin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0T15DRAFT_397956</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H2O(in) = H2O(out)</text>
            <dbReference type="Rhea" id="RHEA:29667"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>glycerol(in) = glycerol(out)</text>
            <dbReference type="Rhea" id="RHEA:29675"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721024.1">
        <property type="nucleotide sequence ID" value="XM_062864930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GSD7"/>
    <dbReference type="GeneID" id="87883759"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015254">
        <property type="term" value="F:glycerol channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1080.10:FF:000027">
        <property type="entry name" value="MIP aquaporin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050363">
        <property type="entry name" value="MIP/Aquaporin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00861">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829">
        <property type="entry name" value="AQUAPORIN OR AQUAGLYCEROPORIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829:SF9">
        <property type="entry name" value="AQUAPORIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02019">
        <property type="entry name" value="AQUAPORIN7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="314"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="91"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3305244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="460" mass="50746" checksum="A542ED5271B03CCC" modified="2024-07-24" version="1">MDPRGQDLEPQPQECHTLPSRDSTNNTTAGNPTHNITKVETRQEVEHTQHHHHKQQQQRIAEDADEKEDALLDNNGNNSNTHRVTSASSSHHSHSRTAVRHTTSKTTTTCHGVNDHGNGGVQRVTSSPTIRNTRARLGLRPAAPINEEEQIAQWQGLRWSRVRVALREPFSEFFGVVTMVVLGNASVAQVLLSTGQREAPGGGGYGGYQSINWGWGIGVMLGLYVAGDSGAYLNPAITFSNCLFRQLPWRRFPSYAVAQLLGAFVGSGIVYANYVNAIDHYEGKGIRTVPPSEKATASIFCTFPQPFLSRSGQFFSEFIASAILVLVVFALRDPGNNGIEKDGKWFPLMMMFLIFALGSGLGWETGNAINPARDLGPRIMATLLGYGSEMWTAGGYYFWIPIVAPFCGCVFGGLLYDVFIYTGASPINTPWMGLKHIFRPDYGWRVARERYRKGIEEGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GSS1</accession>
    <name>A0AAJ0GSS1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rhodanese-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_485069</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721236.1">
        <property type="nucleotide sequence ID" value="XM_062866273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GSS1"/>
    <dbReference type="GeneID" id="87885102"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01448">
        <property type="entry name" value="TST_Repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01449">
        <property type="entry name" value="TST_Repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000001">
        <property type="entry name" value="Sulfurtransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000033">
        <property type="entry name" value="Thiosulfate sulfurtransferase TUM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045078">
        <property type="entry name" value="TST/MPST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364:SF27">
        <property type="entry name" value="SULFURTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364">
        <property type="entry name" value="THIOSULFATE SULFERTANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="86"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="227"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3305456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="351" mass="39093" checksum="86C2175E206311AF" modified="2024-07-24" version="1">MAFIAALNLLRTSLPPRGVRQLCRSTAPPVTAGFTNTKLGVRRSFSSYLVSPQELADALKKSPPSPISSEPRVIPLCASWFLPNDPQGRTGIQVFREKRIPKARFFDLDKVIDKRSPYPHMLPSPKSFAEAMSELGIRHDDTVVVYDSQELGIFSAPRVAWTMKVFGHPKVHILNNFRLWVEQGLPTESGNVWTVECAPYPIPKMDEEKVAHFEQVREVAQDYKKEGAEGVQILDARSYGRWSGKEPEPRPGLSSGHVPGSINIPFDLVLDPETKAFLPADKLRDVFSKKGVDPEKPIISSCGTGVTACVLETALSEAQFGPPEKRKVYDGSWTEWAQRVKPSESLIRSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GT32</accession>
    <name>A0AAJ0GT32_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0T15DRAFT_532137</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family. PPIase D subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721165.1">
        <property type="nucleotide sequence ID" value="XM_062869293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GT32"/>
    <dbReference type="GeneID" id="87888122"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000029">
        <property type="entry name" value="peptidyl-prolyl cis-trans isomerase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000009">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0697">Rotamase</keyword>
    <keyword evidence="8 11" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="12">
        <location>
            <begin position="14"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="11">
        <location>
            <begin position="311"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010898"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3305385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="374" mass="40618" checksum="3E57F8C7D63B58FD" modified="2024-07-24" version="1">MTTDEDKKSRSRVFFDITIGGKPAGRIIFELYNDVVPKTAENFRALCTGEKGVGKGGKPLHYKGSIFHRVIKEFMIQGGDFTAGNGTGGESIYGAKFEDENFELKHDRPFLLSMANAGPGTNGSQFFITTVPTPHLDGKHVVFGEVLSGKSVVRQVENLRTVSDKPTKDAVIADCGELSPSEVVAADTKAPDAYGDEYEDFPEDQVTGDEVLSASQILKIATDCKDFGNKAFKAGDLSVALDKYQKGLRYLNEDPDLDKEPADTKTQMDALRISLNSNAALMNLKLGAWDETVRAADNALAVSGISDKDKAKALYRRGYAQVRLKDEDAALESLEQAKKLAPEDAAINAELVTVKKAAAARLAKEKAAYKKFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GT73</accession>
    <name>A0AAJ0GT73_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8004 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_378526</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721487.1">
        <property type="nucleotide sequence ID" value="XM_062864240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GT73"/>
    <dbReference type="GeneID" id="87883069"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058317">
        <property type="entry name" value="DUF8004"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39601">
        <property type="entry name" value="CHORIOGENIN HMINOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39601:SF2">
        <property type="entry name" value="CHORIOGENIN HMINOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26013">
        <property type="entry name" value="DUF8004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="422"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="670"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="827"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3305707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="827" mass="91814" checksum="F652653E21721FAB" modified="2024-07-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GTA9</accession>
    <name>A0AAJ0GTA9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_533296</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
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            <taxon>Sordariomycetes</taxon>
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            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721533.1">
        <property type="nucleotide sequence ID" value="XM_062869360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GTA9"/>
    <dbReference type="GeneID" id="87888189"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42044:SF1">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42044">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="545"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3305753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="570" mass="63141" checksum="21162B987A2D6858" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GTL6</accession>
    <name>A0AAJ0GTL6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RmlC-like cupin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_203589</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721405.1">
        <property type="nucleotide sequence ID" value="XM_062862602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GTL6"/>
    <dbReference type="GeneID" id="87881431"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02208">
        <property type="entry name" value="cupin_RmlC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="2">
        <location>
            <begin position="69"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3305625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="172" mass="18497" checksum="90CAB2A5F435CED5" modified="2024-07-24" version="1">MASLLPLIQDILPMILPASVAVTKAADILPAQTQPAESESQREGEASGLRVICRNALVDKADKMCASVLVVKPNSSSSVRHHGEQEAILYTVSGNGALLTQPEGDDEKPKRHEIGPGDFAFIPAWTEHQVVNESGVDFHLVVIRSGSKPVEVSLTDWGGPQTREEPQKPMTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GU23</accession>
    <name>A0AAJ0GU23_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BRO1-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_494290</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the palA/RIM20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3306178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721958.1">
        <property type="nucleotide sequence ID" value="XM_062867002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GU23"/>
    <dbReference type="GeneID" id="87885831"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09241">
        <property type="entry name" value="BRO1_ScRim20-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.560">
        <property type="entry name" value="alix/aip1 in complex with the ypdl late domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.50">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025304">
        <property type="entry name" value="ALIX_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030">
        <property type="entry name" value="PCD6 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030:SF39">
        <property type="entry name" value="PROGRAMMED CELL DEATH 6-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13949">
        <property type="entry name" value="ALIX_LYPXL_bnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="4">
        <location>
            <begin position="5"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="479"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="744"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="293"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="640"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="744"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="802"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="845"/>
            <end position="854"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3306178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="870" mass="97695" checksum="8896D66DD136334C" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GUE3</accession>
    <name>A0AAJ0GUE3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Beta-glucosidase cel3A</fullName>
            <ecNumber evidence="5">3.2.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Beta-D-glucoside glucohydrolase cel3A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Cellobiase cel3A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Gentiobiase cel3A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">B0T15DRAFT_375856</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="5"/>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722101.1">
        <property type="nucleotide sequence ID" value="XM_062864230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GUE3"/>
    <dbReference type="GeneID" id="87883059"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000757">
        <property type="entry name" value="Beta-glucosidase G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000003">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF28">
        <property type="entry name" value="BETA-GLUCOSIDASE L-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8 20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 18" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042487648" description="Beta-glucosidase cel3A" evidence="18">
        <location>
            <begin position="17"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="19">
        <location>
            <begin position="654"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="20">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="20">
        <location>
            <position position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00070030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00078013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00083231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00083611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAK3306321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="730" mass="76617" checksum="391A35B0461B08B1" modified="2024-07-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GUT9</accession>
    <name>A0AAJ0GUT9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_527614</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722361.1">
        <property type="nucleotide sequence ID" value="XM_062868987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GUT9"/>
    <dbReference type="GeneID" id="87887816"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="705"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="536"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="323"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="358"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="410"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="541"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="554"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="633"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3306581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="752" mass="79981" checksum="23E70975AE46C58E" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GUW3</accession>
    <name>A0AAJ0GUW3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_136895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722080.1">
        <property type="nucleotide sequence ID" value="XM_062861826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GUW3"/>
    <dbReference type="GeneID" id="87880655"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3306300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="164" mass="18246" checksum="03D25323A624EA9F" modified="2024-07-24" version="1">MPLSASFLRRTNSSPKWRPSMVVLYAYTASARIDGSSGISSRPAANCSTGKKTNWLASACHTMKIKRRLTIRDPVKATLQLAVQPLLELLHGRVLGVLERRLHRLRCRLGDGRDRRRLDVAHARRAALHCRARRNLDLAARPDSRPSAALAGLGCRGRHERGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GV34</accession>
    <name>A0AAJ0GV34_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 5B</fullName>
            <ecNumber evidence="3">3.6.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Translation initiation factor IF-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0T15DRAFT_147551</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="3"/>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722407.1">
        <property type="nucleotide sequence ID" value="XM_062861952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GV34"/>
    <dbReference type="GeneID" id="87880781"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03703">
        <property type="entry name" value="aeIF5B_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01887">
        <property type="entry name" value="IF2_eIF5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000013">
        <property type="entry name" value="eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000026">
        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10050:FF:000002">
        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000112">
        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="entry name" value="Translation initiation factor IF- 2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029459">
        <property type="entry name" value="EFTU-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003078">
        <property type="entry name" value="PRK04004.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381:SF4">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14578">
        <property type="entry name" value="GTP_EFTU_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="Initiation factor IF2/eIF5b, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="15">
        <location>
            <begin position="504"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="227"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="175"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="227"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="321"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="342"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="383"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="393"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="422"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="454"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="467"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3306627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1099" mass="121096" checksum="6707836A4727D1BE" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GV85</accession>
    <name>A0AAJ0GV85_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_566430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722538.1">
        <property type="nucleotide sequence ID" value="XM_062870696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GV85"/>
    <dbReference type="GeneID" id="87889525"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05120">
        <property type="entry name" value="APH_ChoK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="48"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3306758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="240" mass="27994" checksum="B91EE6B54DAA0B98" modified="2024-07-24" version="1">MARNERCNSQGCFATTPDRKYYRRGNAFIKRCLRPREFLPGPQGIHIPRFRKESLKNEADTLRFIRRYTEIPVPMLFADFEDDDAYYLITEYVEGVNMADLPEHQKDVVIAELEGHLAKLKELRSHRMGGPSGIVIPPYRVLCETEREDWSQLRPAESRVYVFCHNDCSQHNIIVNPTTLKIAAIVDWEYAGFYPPYFEFPFYKRNGPSVALGEEEDDTFELLNFLNSQLVDMTTSRTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GVL9</accession>
    <name>A0AAJ0GVL9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NEDD8-activating enzyme E1 regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_484192</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Regulatory subunit of the dimeric UBA3-ULA1 E1 enzyme.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722733.1">
        <property type="nucleotide sequence ID" value="XM_062866213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GVL9"/>
    <dbReference type="GeneID" id="87885042"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019781">
        <property type="term" value="F:NEDD8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01493">
        <property type="entry name" value="APPBP1_RUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030667">
        <property type="entry name" value="APP-BP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF29">
        <property type="entry name" value="NEDD8-ACTIVATING ENZYME E1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039099">
        <property type="entry name" value="APP-BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="5">
        <location>
            <begin position="23"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR039099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3306953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="539" mass="58914" checksum="67C8F21194A1151B" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GVY3</accession>
    <name>A0AAJ0GVY3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">C2H2 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_414043</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722898.1">
        <property type="nucleotide sequence ID" value="XM_062865434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GVY3"/>
    <dbReference type="GeneID" id="87884263"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="180"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="387"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="HTH CENPB-type" evidence="9">
        <location>
            <begin position="761"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="182"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="157"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="354"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="746"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1003"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1135"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="242"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="361"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="751"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1013"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1137"/>
            <end position="1159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3307118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1236" mass="136485" checksum="0AADDA6FD4C33775" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GWC0</accession>
    <name>A0AAJ0GWC0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase M20 dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_553856</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723054.1">
        <property type="nucleotide sequence ID" value="XM_062870336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GWC0"/>
    <dbReference type="GeneID" id="87889165"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03887">
        <property type="entry name" value="M20_Acy1L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.360:FF:000004">
        <property type="entry name" value="Peptidase M20 domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052030">
        <property type="entry name" value="Peptidase_M20/M20A_hydrolases"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575">
        <property type="entry name" value="PEPTIDASE M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575:SF4">
        <property type="entry name" value="PEPTIDASE M20 DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="562"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="570"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3307274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="581" mass="61554" checksum="33A8FAE8CFC6B69F" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GWE8</accession>
    <name>A0AAJ0GWE8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Putative transcription factor kapC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_510408</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Putative transcription factor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the bZIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722875.1">
        <property type="nucleotide sequence ID" value="XM_062867851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GWE8"/>
    <dbReference type="GeneID" id="87886680"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF11">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="10">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="93"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3307095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="205" mass="21791" checksum="B850D371422EBDC2" modified="2024-07-24" version="1">MSGPHAPVAPAVGPVQSPESSADGRKAKRELSQSKRAAQNRAAQRAFRQRKEGYIKSLEQQVRDYQKMEVSYKALQSEHYLLTEYVGTLQSRLLETQGEYPPPPPGLEFTQQPPPSRPDSGATTAQAAVAAGDPAAPAPNPVEVAAQAVAGLSRGEHLAARHPYAQPVRADDDATTAEEITRQLQAEGGSDQLPAVPDGLPAAPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GWH0</accession>
    <name>A0AAJ0GWH0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Immunoglobulin E-set</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_393777</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rho GDI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723065.1">
        <property type="nucleotide sequence ID" value="XM_062864704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GWH0"/>
    <dbReference type="GeneID" id="87883533"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005094">
        <property type="term" value="F:Rho GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.50.30:FF:000004">
        <property type="entry name" value="Rho GDP-dissociation inhibitor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.30">
        <property type="entry name" value="Coagulation Factor XIII, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000406">
        <property type="entry name" value="Rho_GDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024792">
        <property type="entry name" value="RhoGDI_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10980:SF3">
        <property type="entry name" value="LD16419P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10980">
        <property type="entry name" value="RHO GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02115">
        <property type="entry name" value="Rho_GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3307285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="234" mass="25938" checksum="B356E6FC7EAB5F4B" modified="2024-07-24" version="1">MGAEGEFQVQGAQVPRRVRARSPYPRSIPQDEREELSRVVLRVQSSASAILSLSCFQAEADSDIADEGDESLQRYKQSLGLGGGKDLSDPNDPRVCIIQSLTMESPGRDPVVIDLTAPGSVDNLKKTPFKIKEGATFTMTAQFKVQHEILSGLHYVQVIKRKGIRIPGGKSDEMIGSYAPNTDKQPIYTKKFAEETAPSGWAVRGAYTVNSSFVDDDKKTHLQFEWAFEIDKDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GWN1</accession>
    <name>A0AAJ0GWN1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_530427</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723286.1">
        <property type="nucleotide sequence ID" value="XM_062869171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GWN1"/>
    <dbReference type="GeneID" id="87888000"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3307506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="269" mass="29934" checksum="398C255CA677993D" modified="2024-07-24" version="1" fragment="single">MVMGYGLWLWLLPVENGETLNHVTRAGEREGRTKKQTGRQLLILFTLLLFLFFSFSSRFICFSRNSKKGSTSRWNNGKGKGSRATKHGICKDTRRIYCLFAFCAHLFLFLHWLASFFSSLSPSVASSTLPCSGVFLPLFFDYFPLTGLDLAYDDDICPPALSRPSMRKVGGLKERIPSTPCHRGSCRGRQTDRQTRKRGRLGREGGEGKGGWIAPNLKGTALVPAAGQWSIRARPAAKVPTYLVSPSLLLLLPPPPALGLLLFLYEFCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GWR5</accession>
    <name>A0AAJ0GWR5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">O-methylsterigmatocystin oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_492746</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723040.1">
        <property type="nucleotide sequence ID" value="XM_062866880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GWR5"/>
    <dbReference type="GeneID" id="87885709"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF11">
        <property type="entry name" value="OXIDOREDUCTASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3307260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="538" mass="60822" checksum="148A8C8552D0BD12" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GXA3</accession>
    <name>A0AAJ0GXA3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">B30.2/SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_182357</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cclA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723340.1">
        <property type="nucleotide sequence ID" value="XM_062862324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GXA3"/>
    <dbReference type="GeneID" id="87881153"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12872">
        <property type="entry name" value="SPRY_Ash2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037353">
        <property type="entry name" value="ASH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10598">
        <property type="entry name" value="SET1/ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10598:SF0">
        <property type="entry name" value="SET1_ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="5">
        <location>
            <begin position="156"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="519"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3307560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="543" mass="60633" checksum="4ED33CCC8ECF5870" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GXF3</accession>
    <name>A0AAJ0GXF3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">50S ribosomal protein L30e-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_482791</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3307887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_062866125.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87884954"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RIBOSOMAL PROTEIN L30"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="4">
        <location>
            <begin position="14"/>
            <end position="104"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00007326"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3307887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="109" mass="11646" checksum="37939D3E3B4F6D0C" modified="2024-07-24" version="1">MAPKKSKSDAQSIGAKLALVIKSGKVVLGYRSTLKALRSGKAKLILIAANTPPLRKSELEYYSMMSKTAVHHYTGTNIELGTACGKLFRCSTMAILDAGDSDILSDQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GXW4</accession>
    <name>A0AAJ0GXW4_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Vacuolar segregation subunit 7-domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">B0T15DRAFT_88312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
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                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3307890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062871420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GXW4"/>
    <dbReference type="GeneID" id="87890249"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070772">
        <property type="term" value="C:PAS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0010513">
        <property type="term" value="P:positive regulation of phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903778">
        <property type="term" value="P:protein localization to vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000011">
        <property type="term" value="P:vacuole inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024260">
        <property type="entry name" value="Vac7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28258">
        <property type="entry name" value="VACUOLAR SEGREGATION PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28258:SF1">
        <property type="entry name" value="VACUOLAR SEGREGATION PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12751">
        <property type="entry name" value="Vac7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="486"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="912"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="352"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="518"/>
        </location>
    </feature>
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        <location>
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            <end position="561"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3307890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="953" mass="101538" checksum="DBDB2B292E8C4025" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GXZ1</accession>
    <name>A0AAJ0GXZ1_9PEZI</name>
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        <recommendedName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase</fullName>
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    </protein>
    <gene>
        <name evidence="19" type="ORF">B0T15DRAFT_523872</name>
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    <organism evidence="19 20">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
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            <taxon>Sordariomycetes</taxon>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HRD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724007.1">
        <property type="nucleotide sequence ID" value="XM_062868727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GXZ1"/>
    <dbReference type="GeneID" id="87887556"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16479">
        <property type="entry name" value="RING-H2_synoviolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050731">
        <property type="entry name" value="HRD1_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057992">
        <property type="entry name" value="TPR_SYVN1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024766">
        <property type="entry name" value="Znf_RING_H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058051">
        <property type="entry name" value="Znf_RING_synoviolin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763:SF184">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SYNOVIOLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763">
        <property type="entry name" value="RING ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25563">
        <property type="entry name" value="TPR_SYVN1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12678">
        <property type="entry name" value="zf-rbx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="343"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="421"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="488"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="694"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="426"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="491"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="501"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="773"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAK3308227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="847" mass="92875" checksum="A6B06C0CCE785378" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GYU6</accession>
    <name>A0AAJ0GYU6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_491240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724457.1">
        <property type="nucleotide sequence ID" value="XM_062866759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GYU6"/>
    <dbReference type="GeneID" id="87885588"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3308677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="151" mass="17406" checksum="8C7DD732F3CCD448" modified="2024-07-24" version="1">MVGAFHRHTGKLADILTRFNAQEKFGIYLIYGHFRLDEGNIMLGTTLTTVRRCWTKPTRITEVKPAEIHGHIFRLAPNGEMQAYEYHEGPITNLDGIDLAFFRELIKYADVNDLTNVLGLQVLSKVPEMYEFDLKNNGTVMLHEDHIKTRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GYW4</accession>
    <name>A0AAJ0GYW4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_116418</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724493.1">
        <property type="nucleotide sequence ID" value="XM_062861564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GYW4"/>
    <dbReference type="GeneID" id="87880393"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3308713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="104" mass="11163" checksum="43C850E8FFAA6A4B" modified="2024-07-24" version="1">MLAANAATTLPSRFTLCLAIPDHMLKQAPKSSIGFVLGQSVFKLLITGTRLVGHHDTLVYVASAVPRHGRDSGRSKDENHGLAARTFWRGPPHVSAPHHPPGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GZ92</accession>
    <name>A0AAJ0GZ92_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FMN-dependent dehydrogenase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_121129</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724639.1">
        <property type="nucleotide sequence ID" value="XM_062861627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GZ92"/>
    <dbReference type="GeneID" id="87880456"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF104">
        <property type="entry name" value="CYTOCHROME B2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="4">
        <location>
            <begin position="4"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="5">
        <location>
            <begin position="101"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="237"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3308859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="522" mass="55354" checksum="71A3F14F5FEA028E" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GZA4</accession>
    <name>A0AAJ0GZA4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA polymerase</fullName>
            <ecNumber evidence="13">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0T15DRAFT_122748</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the DNA polymerase type-X family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="13"/>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724697.1">
        <property type="nucleotide sequence ID" value="XM_062861646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GZA4"/>
    <dbReference type="GeneID" id="87880475"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00141">
        <property type="entry name" value="NT_POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000062">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.210.10:FF:000005">
        <property type="entry name" value="DNA polymerase IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000010">
        <property type="entry name" value="DNA polymerase lambda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.110:FF:000005">
        <property type="entry name" value="DNA polymerase POL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA polymerase, thumb domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
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        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="DNA-dir_DNA_pol_X"/>
    </dbReference>
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        <property type="entry name" value="DNA_pol-X_BS"/>
    </dbReference>
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        <property type="entry name" value="DNA_pol_B_palm_palm"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037160">
        <property type="entry name" value="DNA_Pol_thumb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022312">
        <property type="entry name" value="DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002008">
        <property type="entry name" value="DNA_pol_X_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="HHH_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029398">
        <property type="entry name" value="PolB_thumb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276">
        <property type="entry name" value="DNA POLYMERASE TYPE-X FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276:SF29">
        <property type="entry name" value="DNA POLYMERASE TYPE-X FAMILY PROTEIN POL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14792">
        <property type="entry name" value="DNA_pol_B_palm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14791">
        <property type="entry name" value="DNA_pol_B_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10391">
        <property type="entry name" value="DNA_pol_lambd_f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00869">
        <property type="entry name" value="DNAPOLX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00870">
        <property type="entry name" value="DNAPOLXBETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00483">
        <property type="entry name" value="POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81585">
        <property type="entry name" value="PsbU/PolX domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00522">
        <property type="entry name" value="DNA_POLYMERASE_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 13" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BRCT" evidence="15">
        <location>
            <begin position="130"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="185"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="568"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU366014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3308917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="614" mass="69079" checksum="4EE0DCE66264FED7" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GZA6</accession>
    <name>A0AAJ0GZA6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_122038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724674.1">
        <property type="nucleotide sequence ID" value="XM_062861637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GZA6"/>
    <dbReference type="GeneID" id="87880466"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042558367" evidence="1">
        <location>
            <begin position="19"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3308894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="303" mass="33019" checksum="E4D3035DAFCCA038" modified="2024-07-24" version="1">MIPRTICLLALLLPLASAEVLGSYTIPTFARNCTADACTYRLALEVAYNNSTEVDATENDQTNCTFTVRAVSPLLAANITNFKNVTCDEDERYRFNGGFNVTGGFLTLVPTDTVAGTYAFFGYSDSEMEAGEVGPRTVDAYRVGTFGDDEWDDGQLGFAASDGREVKEVAVMKRGAGVVGAAEEDPESWWEVRRLTRTPVIQSNTTKTEMVEFSIADVDAGTQTNCTVNLLNQGLTASWYGKPCGLDFRWSISWGYNSDADSAVMTVCYVSNGTAAWFGYEKISNTTSFGDSVKEPVWKTGCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GZW1</accession>
    <name>A0AAJ0GZW1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">HTAFII28-like protein conserved region-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_134736</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3309233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725013.1">
        <property type="nucleotide sequence ID" value="XM_062861794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GZW1"/>
    <dbReference type="GeneID" id="87880623"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08048">
        <property type="entry name" value="HFD_TAF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045127">
        <property type="entry name" value="TAF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006809">
        <property type="entry name" value="TAFII28_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13218:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13218">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04719">
        <property type="entry name" value="TAFII28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAFII28-like protein" evidence="7">
        <location>
            <begin position="184"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="259"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="149"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="311"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3309233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="371" mass="39566" checksum="A2C1A329690EB268" modified="2024-07-24" version="1">MASPTAHSPPHTSHIQLANINTMTSNKKRASEGAAPPALKRRAISTPSGPGSAHPLRQTSFPPDDAGTPYGPMSPSSIADVDAMSTVSGSLVNAAAPVKKKRGRKSKAEKAREQTPSVVGGRAPTAISGVSEGGGRGTKSVSGAAGGAGDEDGEGDDEGPTEVAATADIQTKEQKEEEHRKRQMLISALSEEQFDRYENWRAGNLSKASVRRLINATTSQSVPENVVITMRAVSKVFIGDIIEGARRVQGEWIKNGEKQTDLPADQMPGQTLAQSSSQAQSAAQTESPAQATPDSASKADTQEQPPPPQQHRQETDDRRGPLRPDHLREAIRRYRVSGEGGGVGMQRIFHQQQQGGAERFPMRTGGYRIFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GZZ9</accession>
    <name>A0AAJ0GZZ9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glucan 1,3-beta-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_526785</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3309291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725071.1">
        <property type="nucleotide sequence ID" value="XM_062868926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GZZ9"/>
    <dbReference type="GeneID" id="87887755"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000130">
        <property type="entry name" value="Endoglucanase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF13">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="6">
        <location>
            <begin position="101"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3309291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="504" mass="57197" checksum="D31431AA6667854C" modified="2024-07-24" version="1">MSTATTRTTAGLAQDVSVRVELTHTPPRLTMLRASGTDIVNAAGDKVILKGAGLGGMLNMENFITGYSGHEHEHRVALAEVLGKEKAAFFFDRLIHHFFTDADAALFVSLGLNCLRVPFNYRHFMDDDNPNVIKPEGFALLNRVVDICGRHGIYVVLDLHAVPGGQNQDWHSDSGLSRALFWEFRDFQDRAVQLWRAIAAHYAGNPVVAGYNPLNEPADPQHARLVAWYERVERAIRAVDPDHMLFLDGNTYAMDFSAFDPARALPNAVYSCHDYARLGFPGGEQYDGSDAQRLHLRASFARKVAFMRAAGVPIWNGEFGPVYQQHDRDGAESAEATNERRFALLREQLRIYREFDAPVSWSIWLWKDIGYQGMVHLDPDSAYMRLVRPFVEKKKRLGLDFWGVADKSAVDGEVYAPFIAKLREMVPAHLLRKKYPNTWTFDRQVERVVRECLMSEYLGWEMAELFANKTEVELEELASSFALEKCVTRVRLNEILRSDAQLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H0T6</accession>
    <name>A0AAJ0H0T6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADP-dependent dehydrogenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_388058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725230.1">
        <property type="nucleotide sequence ID" value="XM_062864422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H0T6"/>
    <dbReference type="GeneID" id="87883251"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052184">
        <property type="entry name" value="SDR_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458:SF1">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3309450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="254" mass="26761" checksum="CDB25C2DFB89F131" modified="2024-07-24" version="1">MPVYVITGARTGIGLEYVRQLSRAVPPQSNTIFAVVRKLDSDLTALRAVQSSVPNPETKVHIVECDISSPASIAALPDRIRNANPSNPAAEIRIDTLINNAATLHSREETALSLTPSALQSHIASNVLGPALVLQALLPLLSPRAKVANVSSGIASMALVRDGSIKAEITPYSVSKAALNMLTVHQARQLRGIDAYKEVVVVAVDPGHVKTEMGGPNAVVEVADSASGVLKVLEGLGVKDTGRFLLYTGAELPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H1G2</accession>
    <name>A0AAJ0H1G2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Proteasome stabiliser-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_516524</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725575.1">
        <property type="nucleotide sequence ID" value="XM_062868259.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87887088"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024372">
        <property type="entry name" value="Ecm29_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055443">
        <property type="entry name" value="HEAT_ECM29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346:SF19">
        <property type="entry name" value="PROTEASOME ADAPTER AND SCAFFOLD PROTEIN ECM29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR GCN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23731">
        <property type="entry name" value="ARM_ECM29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13001">
        <property type="entry name" value="ECM29_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24492">
        <property type="entry name" value="HEAT_ECM29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Proteasome component Ecm29 N-terminal" evidence="6">
        <location>
            <begin position="15"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome adapter and scaffold protein ECM29 HEAT-repeat" evidence="7">
        <location>
            <begin position="1287"/>
            <end position="1447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1695"/>
            <end position="1725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1772"/>
            <end position="1794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1695"/>
            <end position="1704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1705"/>
            <end position="1715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1772"/>
            <end position="1781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1782"/>
            <end position="1793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3309795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1936" mass="211428" checksum="B088F00CF2711B24" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H1L7</accession>
    <name>A0AAJ0H1L7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">calcium/calmodulin-dependent protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0T15DRAFT_481625</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.17" evidence="2"/>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725942.1">
        <property type="nucleotide sequence ID" value="XM_062866042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H1L7"/>
    <dbReference type="GeneID" id="87884871"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004683">
        <property type="term" value="F:calcium/calmodulin-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000449">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000278">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
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        <property type="entry name" value="PROTEIN_KINASE_ST"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="3 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
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        <location>
            <begin position="23"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00005354"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00047430"/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3310162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="401" mass="45654" checksum="F2A10767755454FB" modified="2024-07-24" version="1">MSFTNMLNRLHGQPESYDKKSRYRFGRTLGAGTYGIVREAEGPQGRVAIKIILKKVVRGNERMVLDELEMLQRLKHPHIVKFVDWFESRDKYYIVTELATGGELFDRICQYGKFTEKDASQTIKQVLDAVNYLHQNNVVHRDLKPENLLYLTKDADSDLVLADFGIAKMLGTKDEVLTTMAGSFGYAAPEVMLKQGHGKPVDMWSLGIITYTLLCGYPPFRSENLQDLIDECTACRVVFHERYWKDVSNDAKDFIMSLLRAKPEERWTSERALSHPWLSGQNATDHNLLPEIRAYLTRARLRRGIEMVKLANRIEALKAQEEDPENSDMPKDATLAADQTRHFNTLAANNHGSDSVEGGGKRTLSKTIKGAIFREVVLAKVREMKEKEETLKLTEEASKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H2G8</accession>
    <name>A0AAJ0H2G8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0T15DRAFT_31972</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062864037.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87882866"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="Nitrogen regulatory AreA, N-terminal"/>
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    </dbReference>
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        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
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    </dbReference>
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        <property type="entry name" value="AreA_GATA"/>
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        <property type="entry name" value="Transcription_factor_GATA"/>
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        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF281">
        <property type="entry name" value="BOX A-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08550">
        <property type="entry name" value="GATA_AreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="11">
        <location>
            <begin position="696"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
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            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="281"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
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            <begin position="544"/>
            <end position="702"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="10">
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            <end position="839"/>
        </location>
    </feature>
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    </feature>
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            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
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            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
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            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="606"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
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            <begin position="677"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
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            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
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            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
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            <end position="835"/>
        </location>
    </feature>
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        <location>
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            <end position="872"/>
        </location>
    </feature>
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            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="919"/>
            <end position="947"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3310285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="970" mass="101052" checksum="2835A89BD7096CF1" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H2H7</accession>
    <name>A0AAJ0H2H7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_488984</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
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        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <person name="Hensen N."/>
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                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
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                <person name="Cros-Aarteil S."/>
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
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                <person name="Kuo A."/>
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                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
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                <person name="Chen C."/>
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                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
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                <person name="Ament-Velasquez S.L."/>
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                <person name="Grigoriev I.V."/>
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        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Cros-Aarteil S."/>
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
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                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
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                <person name="Chen C."/>
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                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        </location>
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            <dbReference type="Proteomes" id="UP001273166"/>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Grigoriev I.V."/>
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                <person name="Hiltunen Thoren M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="5">CBS 333.67</strain>
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        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
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                <person name="Labutti K."/>
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                <person name="Grigoriev I.V."/>
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                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
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        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
    <dbReference type="Pfam" id="PF00013">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="120"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="203"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="405"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="301"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="370"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3310515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="490" mass="51289" checksum="9B8EDD79BD0B8FE7" modified="2024-07-24" version="1">MSTSPQPTQSAKRPLEETSSPSVADQPEAKRPALDKVIKDQQEIAEPIAASNGNDSTVPAAAPEANGAAKPNGEKSDVKDAQGDTVVPDAPETKPITSTASGSTSQEQSNPPQAAHDETAWIHVRAVISSPEAATIIGKGGENVSKIRQMSGAKCTVSDYQKGAVERILTVSGIVDAVAKAFGLIIRTLNNEPLTEPSSQHSKTYPLRLLIPHILIGSIIGKGGARIKEIQEASGARLNASDSCLPLSTERSLVVMGVADAVHIATYYVGSTLLQQLNERFGGAAASAYATRSGGPAGAVPGGMQVIPYNPQPASGNYGNRDHYHRGRPDPRAHPMPPQSYVPQYGHPHATHPTAAVPMPYGAHAAAGYPAGPHVGPHPAGPAGPHAHPAPHGAPLPGGAAIPGAPLTQQIYIPNDMVGAIIGKGGQKINEIRQISGSVIKINEPQDNSNERLVTITGTEECNRMALYMLYSRLGKLREQHSHQSQSQQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H3T5</accession>
    <name>A0AAJ0H3T5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein transport protein SFT2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_521071</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Nonessential protein required for the fusion of transport vesicles derived from the endocytic pathway with the Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Golgi apparatus membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the SFT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727103.1">
        <property type="nucleotide sequence ID" value="XM_062868542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H3T5"/>
    <dbReference type="GeneID" id="87887371"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011691">
        <property type="entry name" value="Vesicle_transpt_SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137:SF36">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN SFT2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3311323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="190" mass="20818" checksum="DC01B852245469BD" modified="2024-07-24" version="1">MASTSFRDSINSLGWSRRDADLPVNTSRQGGFLSSLQSLNPFGDRGYVRLPTTEGAGAPLPAPSRREEEDAWFALSRWDRLLIFGACNLGALACFVICFALFPVISLGRPRKLVVLWTLGSMLFLSSFAAIMGPWAYLQHLASTPRLPFTAAYFGSLGLTLYFSIGVSQTLHPKDRNLDTEASFSCKAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LYR9</accession>
    <name>A0AAJ0LYR9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_497014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718333.1">
        <property type="nucleotide sequence ID" value="XM_062867234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LYR9"/>
    <dbReference type="GeneID" id="87886063"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF291">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3302553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="217" mass="23784" checksum="07F7AAFC0CAE60DE" modified="2024-07-24" version="1">MADNTSLINLPTGFDFKDYIGGGNSGIVLLDKHTLTVIKIRLDGDHSPEIDIERQIYERFIERGGQKGIPIFYGTFKHGIRLDHVAEALDFVHECGVIHGDVQGFNVLIDWRLDAKLADFAGSSLDGSPLLIATNESHTCPGRGLSRKGDIFALGSTNYELMTGCPPYAGLSDSVIRSRYSKGQYPDTKSLGAVGSIITKCWRGNCEELHSRLLVTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M0B2</accession>
    <name>A0AAJ0M0B2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_494748</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720057.1">
        <property type="nucleotide sequence ID" value="XM_062867039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M0B2"/>
    <dbReference type="GeneID" id="87885868"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF30">
        <property type="entry name" value="MID2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="270"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="33"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="99"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="116"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="217"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="287"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="359"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3304277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="421" mass="42825" checksum="C0CD741517CD5262" modified="2024-07-24" version="1">MPFRSAHVETDMADPYRDFPRLKRQTFTMSNNTSSIDGAADTSTTAAPSPPQTTTTEVTSSSPSSTPPAPPPSTTSTTSSSSSTAPPPAPPTTSTSSSSPPPVAPPPSSTTPPPSSSQGESSVSSLPPDDVTSTPPSTTFIIITETSTHPGGTGSITSSSATSTSTSGSAISPSDGSDGGGLSNGGKIAVAVVVPIAAVALLLLAGIFFWRKRKQRKDAEEQRRKEVEDYGYNPNADPTIPAVAGTAYEMREDGSSGYRGWGSTPIVGSTGRKASTTMSGGAGAYSDATSPTRATADTRSGEPLMGDVPPSPEGEILGAMGPSAANNRADVRRGPSNASSSYSAAGRSDGSGDPPIGVAYGGGDQYYDQYGGGNPYTDNGYPPHPGPSASPVIRDVTARRNTRIENPAHYPQQTAGISQNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M0E0</accession>
    <name>A0AAJ0M0E0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">2-(3-amino-3-carboxypropyl)histidine synthase subunit 1</fullName>
            <ecNumber evidence="3 11">2.5.1.108</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0T15DRAFT_238840</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36783"/>
            <dbReference type="Rhea" id="RHEA-COMP:9748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="EC" id="2.5.1.108"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the DPH1/DPH2 family. DPH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.108" evidence="3 11"/>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720146.1">
        <property type="nucleotide sequence ID" value="XM_062863045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M0E0"/>
    <dbReference type="GeneID" id="87881874"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11840:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11850:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11860:FF:000002">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11850">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042264">
        <property type="entry name" value="DPH1/DPH2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035435">
        <property type="entry name" value="DPH1/DPH2_euk_archaea"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF1">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004967">
        <property type="entry name" value="DPH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3304366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="445" mass="49008" checksum="02A73846AE36C60C" modified="2024-07-24" version="1">MEGHSEHVELGAIAEVEERPNHENTVKQPKKRFVGKRAAAEAAKSNSGAASIEDSGAIQVAQPRRAPRMVNQIPHEILNDEALKAAIALLPANYAFEIPKTIHRIRSLGAKKVALQMPEGLLMFATTISDILTEFCPGIETLIMGDVTYGACCIDDYTARAMGCDLLVHYAHSCLIPAGVTKIKTLYVFVNISIDTSHMLTTLERNFSPGKTIAIVGTIQFNATIHGVRSTLEKAGFKVVIPQIAPLSKGEILGCTSPDLSTYTDSPIDLILYLGDGRFHLESIMIQNPGIPAYRYDPYSRKLTHETYGHDEMQDVRRDAIRKAKTARKWGLILGSLGRQGNPHTMALIETKLRQMGIPFVNLLLSEIFESKLAMMGDIECWVQVACPRLSIDWGYRFPRPLLTPYEALVALEEREDWGKGPYPMDYYGKEGLGRTAPVAAGGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M0I9</accession>
    <name>A0AAJ0M0I9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_494974</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720300.1">
        <property type="nucleotide sequence ID" value="XM_062867069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M0I9"/>
    <dbReference type="GeneID" id="87885898"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="13"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3304520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="321" mass="32176" checksum="282B2542773724D1" modified="2024-07-24" version="1">MADFEAPPGPPPPKVPEGWIVRWNEQYKEWFYVNSYTKKSQWEKPTEPARPPEDDLAPPGAPPSYTPGGHTPGPTDVKHNPFDPAPGNQAGAGQAGAPSSSAVSHNTEEEDARLARQLQAEEDARARGAHSPNPPYSAHSPSPFPEQLPPRPDGGSAYPAGGAGGDKGRGLLGKLFGGGKNKQSSSHGGGMPGALGGLMAGGSSHHGAGHHQGGYGGYPGGGYGGGGAYGAPPYGGGYPPPQPYGGYPPHGGYYPPQQAYGHSGRSGGGGMGAMGGAALGLGAGVLGGALIADAIDDSQDAAYAEGYNDGADGGDFDGGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M0N7</accession>
    <name>A0AAJ0M0N7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_249289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720419.1">
        <property type="nucleotide sequence ID" value="XM_062863152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M0N7"/>
    <dbReference type="GeneID" id="87881981"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042582711" evidence="1">
        <location>
            <begin position="26"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3304639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="143" mass="14593" checksum="312533A8C5982054" modified="2024-07-24" version="1">MKLIAALPHVSLAVAAVLEPRHCAGNNCNRAVTGTRPGLLPLASRSADCSSFLLTTVTPAATTVTVTVDEEDLPSPTAAKRGAVLQGRQVTVVPSAIPDYAANCANAAEYISACSCFGVTGSVTTAPTPTVTVTTTVDYCEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M1B3</accession>
    <name>A0AAJ0M1B3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Parallel beta-helix repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_531897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721077.1">
        <property type="nucleotide sequence ID" value="XM_062869283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M1B3"/>
    <dbReference type="GeneID" id="87888112"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042560923" description="Parallel beta-helix repeat protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3305297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="36637" checksum="26C01D6E62553075" modified="2024-07-24" version="1">MVQFMLSVLAAALSLASAVTAQCGSGSPHATVTGSGSSFKATRGSSTVYSGSDYRAAIQAALDSISSGQRVAVMASGSIGASTITISSGKIFEGCGTINVGNRAGRGAIESTNTADVQIPYLTMTGNPYFGLRFSGTRNLSLGRITMNLSGGLGIRFDRDAAANSNVKMDVISVTGAGSHAVETWNIDGLTINQVIARNVGESGLLLQKTTNAQVGLVDGNNVGAGTGYATLRMANNNGQNANGNYNTNVYVDRVVSRGGGRGVFCVSQSGAAVIKEVDLASNGNNAILIENCYNVSIRGGIVNGGGEVRLAARSEFPNNRDIWITLTVNNNSVRESPCGENTNWTLSGNAAKNIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M1C7</accession>
    <name>A0AAJ0M1C7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridine nucleotide-disulfide oxidoreductase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_555520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721185.1">
        <property type="nucleotide sequence ID" value="XM_062870394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M1C7"/>
    <dbReference type="GeneID" id="87889223"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF24">
        <property type="entry name" value="NUCLEOTIDE-DISULPHIDE OXIDOREDUCTASE AMID-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17180)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="1">
        <location>
            <begin position="10"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3305405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="425" mass="46051" checksum="40F572C8AFE904A5" modified="2024-07-24" version="1">MGSIPTEPVRVLVAGGSYGGLSAALNLQDLCRGLPPRCGPKPAAGEQQVERPQFEVEITVVDERDGFYHLIGSPLALASEAYAEKCWVKYDDIPALRRAENNIRVLHGTVQSVDPQRKVATYAAHGAATPPLELQYDYFVAASGLRRVWPVVPQSLRRKQYLFEAGDHIRAATAARHGVVIVGGGAVGIEMAAELKLVQPHIKVTLVHSRDKLLSSEPLPEEVKDVSLELVREAGVDVLMSHRLDRTEETEDEHGNKCLRLHFTNGHTMLADQVSLAVSRPTPSTSFLPSSVLDEEGYVKIQANLNFPATTPNAADHFAIGDLVKWSGIKRCGAAMHMGYYAANNIHQRMQNKTADDGSSSSSFLELAEIPPMIGLAVGKKAVSYWPEGGVTAGEEVTKLFFGDDLGFSICWNHLGLGGDKVVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M1G9</accession>
    <name>A0AAJ0M1G9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase kappa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_396338</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721242.1">
        <property type="nucleotide sequence ID" value="XM_062864832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M1G9"/>
    <dbReference type="GeneID" id="87883661"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03586">
        <property type="entry name" value="PolY_Pol_IV_kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.810:FF:000001">
        <property type="entry name" value="DNA polymerase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.810:FF:000003">
        <property type="entry name" value="DNA polymerase kappa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000014">
        <property type="entry name" value="DNA polymerase kappa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.100:FF:000010">
        <property type="entry name" value="DNA-directed polymerase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000039">
        <property type="entry name" value="Polymerase (DNA directed) kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.60:FF:000012">
        <property type="entry name" value="Putative DNA-directed polymerase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DDI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722426.1">
        <property type="nucleotide sequence ID" value="XM_062861957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M2G7"/>
    <dbReference type="GeneID" id="87880786"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01796">
        <property type="entry name" value="Ubl_Ddi1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033882">
        <property type="entry name" value="DDI1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12917">
        <property type="entry name" value="ASPARTYL PROTEASE DDI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12917:SF1">
        <property type="entry name" value="AT13091P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="6">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="205"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="225"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="293"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="314"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="331"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="343"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3306646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="397" mass="43566" checksum="EC68EDC0C0F2C23C" modified="2024-07-24" version="1">MRITLSITNSEPQSDEQDLLSLEVYPEMTIETLRSSIQAETTHHPSAQHLYHNGQLLTDNSKTLAELGVTDGDMLALHVRDMRGNTAVPAAGRQQAAQGGPRSAQRPPAEQDPEVIRLQILGDPNLRGELARSRPDLVASLEDPQAFARLFADSLNRERREREERHRQIQMLNADPFDPEAQAKILEIIRQDQVMENLQNAMEHNPEGAGGLGRASNHHEPAVRRGLRHHAPGRQALRRCRTGCRHRQHHRPRALGADEDWPALPAVQLHGHGGQAGGVAPGPRHAEAPSSLHRSRQRQAGHPGHRGAIPWSGRHSEGQRSRDSGGADRARSRRDHHRTALRRSACTGSGTSATPSGPSRPKHAAEGSSSARTEFPKRTHRTAHGARGIRAESNPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M2P3</accession>
    <name>A0AAJ0M2P3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidine acid phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_566519</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722651.1">
        <property type="nucleotide sequence ID" value="XM_062870697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M2P3"/>
    <dbReference type="GeneID" id="87889526"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000065">
        <property type="entry name" value="Similar to histidine acid phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016274">
        <property type="entry name" value="Histidine_acid_Pase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF14">
        <property type="entry name" value="ACID PHOSPHATASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000894">
        <property type="entry name" value="Acid_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="57"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="197"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="245"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="406"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000894-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3306871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="464" mass="51437" checksum="B15F0ACDA3DCB0CE" modified="2024-07-24" version="1">MVQEQGPISRFLPFAQFASGKTLYSTYSFNPLEHLGGVAPYFEPQDPPTDPAPPQGCTPSRVAYLNRHAAIYANDYDYDEYIGPFVEKLENNTAIDWSKIPSLNFLADWTAPFSEAEAELLTQVGKLEATQLGVSLDLRYPQLRPPSKVWTSSAERTYKSARSFVRGLETDDNQINVVSIYESKEAGADSLTPYKSCPAYSSSAGSDQSSVYKERFTKPIMARLNALAPGFNFTSDDIYGMMELCGYETVVRGKSPFCDLDLFSPNDWLAWEYSEDIRYHYNVGYGNQVSGPVGLPWFNATAHILMTDTAAEDMYVSFTHRELPPMVLVAMGLFNNSDIGGTETTINDTMPLDRINYRRAWKSSHVLPFMSNIAIERLNCTGSYGYDNGDYYRVLVNSASQELPGCGDGPGNSCSKNGFAKYVQERVAMFDGFSEKCGVSYKNTTDVLSIYSDPSVGNGTVVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M326</accession>
    <name>A0AAJ0M326_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7704 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_510502</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722982.1">
        <property type="nucleotide sequence ID" value="XM_062867857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M326"/>
    <dbReference type="GeneID" id="87886686"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056121">
        <property type="entry name" value="DUF7704"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37019">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37019:SF2">
        <property type="entry name" value="EXPERA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24803">
        <property type="entry name" value="DUF7704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7704" evidence="2">
        <location>
            <begin position="4"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3307202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="158" mass="17117" checksum="3AF63943A1AAC30B" modified="2024-07-24" version="1">MARSTLPTFPLLVFGIIEPLLLVWAYIIGMGNPHEYLAKQIPGGSPSTTSFSPQAEGVTLQLINVFLLLAPMAVICCFSSDPATVKGYLFAVALADYGHMYATYRAVGEEVFFNTSLWNDMVWGGVAVNATLNVLRWLTLFGAFGRIAPAAGKAKKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M364</accession>
    <name>A0AAJ0M364_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_484290</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722819.1">
        <property type="nucleotide sequence ID" value="XM_062866222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M364"/>
    <dbReference type="GeneID" id="87885051"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.590:FF:000010">
        <property type="entry name" value="GRF zinc finger domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032854">
        <property type="entry name" value="ALKBH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010666">
        <property type="entry name" value="Znf_GRF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212:SF4">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06839">
        <property type="entry name" value="Zn_ribbon_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51999">
        <property type="entry name" value="ZF_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CUE" evidence="6">
        <location>
            <begin position="30"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="7">
        <location>
            <begin position="247"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="GRF-type" evidence="8">
        <location>
            <begin position="373"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="422"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3307039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="452" mass="50666" checksum="AB2374DE0CD2956E" modified="2024-07-24" version="1">MDAFVTRKKRKSRPDSESSATPGNDAHEDSTDMKLAILSSLHPHSDQETLLDILLAHDGDVGATSQALKTPLLPKKTGGSSTVAAQSSLRSFGLASPSSGSSPSSKRAKLLSRKGATLHLYDPIDISEHTPCTIIHNFLPAEQADSLLLELLEESKTFEKITFKLFDNVVSSPHTSGFYVGSYKELQEQKHEYIYNGMKLTDVRTLTPQLERVRARVQEAVNKEIQDRIRTHYGGKKLRYQSPEPWTPNAAFVNCYNGPQENVGWHSDRLTYLGPRAVIGSLSLGVTREFRVRRIVPDDEPDKPNKPDLAGQIAIHLPHNSLLVMHADMQEEWKHSVSPALAIDPHPVAGSRRINITYRHYRAGFHPRNTPRCPCGVPAVLRVVTKKRENWGRYFWMCYAGNVPGKEACEFFRWAEFDDDGNPVGMKQQDWGLRDEARPDAAEQKKIEVTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M391</accession>
    <name>A0AAJ0M391_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_484559</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723225.1">
        <property type="nucleotide sequence ID" value="XM_062866232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M391"/>
    <dbReference type="GeneID" id="87885061"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF17">
        <property type="entry name" value="HELICASE-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="285"/>
            <end position="444"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="475"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
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            <begin position="296"/>
            <end position="305"/>
        </location>
    </feature>
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        <location>
            <begin position="490"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="506"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3307445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="521" mass="59198" checksum="AFE8A104B7CCEB4D" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M3A0</accession>
    <name>A0AAJ0M3A0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">VASt domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_530368</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YSP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_062869166.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:endoplasmic reticulum-plasma membrane contact site"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120015">
        <property type="term" value="F:sterol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Cholesterol_transport"/>
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        <property type="entry name" value="GRAM"/>
    </dbReference>
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        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031968">
        <property type="entry name" value="VASt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319:SF4">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16016">
        <property type="entry name" value="VASt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51778">
        <property type="entry name" value="VAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="977"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="domain" description="VASt" evidence="8">
        <location>
            <begin position="742"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="318"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="392"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="643"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="919"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="103"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="264"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="342"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="414"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="660"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="925"/>
            <end position="934"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3307486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1102" mass="117531" checksum="6C1DF1C98EE67051" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M3T3</accession>
    <name>A0AAJ0M3T3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SSCRP protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_502181</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723494.1">
        <property type="nucleotide sequence ID" value="XM_062867417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M3T3"/>
    <dbReference type="GeneID" id="87886246"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="PANTHER" id="PTHR40368">
        <property type="entry name" value="YALI0F14399P"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="YALI0F14399P"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042536814" description="SSCRP protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3307714.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="31969" checksum="DF9540AC9E119C7F" modified="2024-07-24" version="1">MMVISALFVVAASLAQALAAGHENSLPAYHYGAPIRVECMNRSSETGEHIENAAHEIQWVPFPVCNETNKPLEFHYGIEGEQNCTIAMVSDPFFHLLEFYIHSDAPLSCRLPARPPPHVEVVGEDAPKQEYIPLVFALAGTLQLSHMHISTHLNVLLHSTPKHHIHRHDSGVLDSATAYSTSPLTHMEGSATRRLVIGDPLPLSFSVRWFPTPALPKIDGKVEWSGMGGHIYASTVFYSLVSFCAGAVVSAAYFFGSVLPRRLNGRRLGGATPLGYGLHGVGNGWGYQKRAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M400</accession>
    <name>A0AAJ0M400_9PEZI</name>
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        <recommendedName>
            <fullName evidence="10">Protein transport protein sec16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0T15DRAFT_100618</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Involved in the initiation of assembly of the COPII coat required for the formation of transport vesicles from the endoplasmic reticulum (ER) and the selection of cargo molecules. Also involved in autophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SEC16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723971.1">
        <property type="nucleotide sequence ID" value="XM_062861354.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87880183"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09233">
        <property type="entry name" value="ACE1-Sec16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1030:FF:000008">
        <property type="entry name" value="Protein transport protein sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024340">
        <property type="entry name" value="Sec16_CCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024298">
        <property type="entry name" value="Sec16_Sec23-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13402">
        <property type="entry name" value="RGPR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13402:SF6">
        <property type="entry name" value="SECRETORY 16, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12932">
        <property type="entry name" value="Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12931">
        <property type="entry name" value="TPR_Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Sec16 central conserved" evidence="13">
        <location>
            <begin position="967"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="domain" description="Sec16 Sec23-binding" evidence="12">
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            <end position="1449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="11">
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    <feature type="region of interest" description="Disordered" evidence="11">
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    <feature type="compositionally biased region" description="Polar residues" evidence="11">
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            <end position="20"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="11">
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            <end position="193"/>
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            <end position="256"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
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    <feature type="compositionally biased region" description="Pro residues" evidence="11">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
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    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="11">
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    <feature type="compositionally biased region" description="Low complexity" evidence="11">
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    <feature type="compositionally biased region" description="Low complexity" evidence="11">
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1948"/>
            <end position="1957"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3308191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1965" mass="206835" checksum="74EEDAAF47883927" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M412</accession>
    <name>A0AAJ0M412_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Methionine aminopeptidase 2</fullName>
            <shortName evidence="9">MAP 2</shortName>
            <shortName evidence="9">MetAP 2</shortName>
            <ecNumber evidence="9">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0T15DRAFT_91372</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9 10">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="9">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="9"/>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3307954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723734.1">
        <property type="nucleotide sequence ID" value="XM_062871446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M412"/>
    <dbReference type="GeneID" id="87890275"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01088">
        <property type="entry name" value="MetAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03175">
        <property type="entry name" value="MetAP_2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050247">
        <property type="entry name" value="Met_Aminopeptidase_Type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002468">
        <property type="entry name" value="Pept_M24A_MAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018349">
        <property type="entry name" value="Pept_M24A_MAP2_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00501">
        <property type="entry name" value="met_pdase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777:SF2">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01202">
        <property type="entry name" value="MAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="12">
        <location>
            <begin position="128"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="58"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="424"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="424"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3307954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="443" mass="48677" checksum="63C52DF662FEC890" modified="2024-07-24" version="1">MAAQAPTEELNQLSVEDAGSKPKPDASATSNGNLNHDSDDSEDDAEDPAAAGGEGGAAKKKKKRKPRKKKKNPKQQSDPPRVLISQLFPDKKYPKGEEVEYVNENRYRTTSDEKRHLDNLKSEFVNDYRHAAEAHRQVRQWAQKNIKPGQTLTEIAVGIEDAVRALTGHQGLEEGDALVAGMGFPTGLSINHCAAHYTPNAGNKMVLQDDDVMKIDFGVHVNGNIVDSAFTMAFNPRYDPLLEAVRAATNEGIKQAGIDARLGEIGGAIQEVMESYEVEIDGTTYPVKSIKNLNGHTILPYNIHGTKSVPIVKSNDTTKMEEGDVFAIETFGSTGQGFVREDGEVSHYALRSDAPKGDLRLTSAKSLLNVIKKNFGTLPFCRRYLDRLGQDKYLLGLNNLVSNGIVESYPPLVDRKGSYTAQFEHTILIRPTVKEVISRGDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M4C9</accession>
    <name>A0AAJ0M4C9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_524270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724154.1">
        <property type="nucleotide sequence ID" value="XM_062868752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M4C9"/>
    <dbReference type="GeneID" id="87887581"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3308374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="71" mass="7772" checksum="79C3C05FE04379A1" modified="2024-07-24" version="1">MSWCGQGPYINGELSAGGMTLWATTGEYGTLRLNGTAYTGRVDAVHGWDCVSDPALPDHREWDGHHVPDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M4K6</accession>
    <name>A0AAJ0M4K6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cupin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_491404</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724632.1">
        <property type="nucleotide sequence ID" value="XM_062866773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M4K6"/>
    <dbReference type="GeneID" id="87885602"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF99">
        <property type="entry name" value="BIFUNCTIONAL PEPTIDASE AND (3S)-LYSYL HYDROXYLASE JMJD7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="2">
        <location>
            <begin position="171"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3308852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="384" mass="43077" checksum="7A2E8111CD7E0358" modified="2024-07-24" version="1">MEDQKSQDPVEELIINYNELNSSVIEELSEEPSPLEFMRFVARNTPFVVRGAAADWRATRTWNVNFLKELLDDEAVNVAVTPAGNADAPTPFTSPDGTTTLVFAKPHEEDQPFGAFLDYLIAQEQHSRRLPASQASSSPSRRTPARAPTRRSAEESQREEIRYAQTQNDNLRHEYRALFAHVPPSIPFARIALAREPEAINLWIGNSHSVTALHKDNYENVYVQIAGQKHFVLLPPVCHACVNETALKPAHYRRSSVGRRSSEGEDERDRREDEQAGGGSLGGAGLELVVEEGEEEVPFAVWDPDTPEENSTPYSALAQPMRVTLNPGDMLYLPCMWYHKVAQSCSPEGVCIAVNYWYDMDFTGPLYPLSTFVRSVSNRRDMAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M4S3</accession>
    <name>A0AAJ0M4S3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">U3 small nucleolar RNA-associated protein 25</fullName>
            <shortName evidence="10">U3 snoRNA-associated protein 25</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0T15DRAFT_127793</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 10">Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Nucleus</location>
            <location evidence="2 10">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the UTP25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3309046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724826.1">
        <property type="nucleotide sequence ID" value="XM_062861711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M4S3"/>
    <dbReference type="GeneID" id="87880540"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002356">
        <property type="entry name" value="U3 small nucleolar RNA-associated protein 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010678">
        <property type="entry name" value="UTP25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053939">
        <property type="entry name" value="UTP25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053940">
        <property type="entry name" value="UTP25_NTPase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12933">
        <property type="entry name" value="ORF PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12933:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 25 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06862">
        <property type="entry name" value="Utp25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22916">
        <property type="entry name" value="UTP25_NTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 10" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7 10" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="UTP25 NTP hydrolase-like" evidence="13">
        <location>
            <begin position="260"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="UTP25 C-terminal" evidence="12">
        <location>
            <begin position="528"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="62"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
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                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
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                <person name="Ng V."/>
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                <person name="Steindorff A."/>
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                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
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                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
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                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 333.67</strain>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
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                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
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                <person name="Ament-Velasquez S.L."/>
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                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Guillou S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="4">CBS 333.67</strain>
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    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
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                <person name="Cros-Aarteil S."/>
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
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                <person name="Steindorff A."/>
                <person name="Ohm R."/>
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                <person name="Ament-Velasquez S.L."/>
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                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
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    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725683.1">
        <property type="nucleotide sequence ID" value="XM_062864251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M5J6"/>
    <dbReference type="GeneID" id="87883080"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF90">
        <property type="entry name" value="CENTROMERE DNA-BINDING PROTEIN COMPLEX CBF3 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="15"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3309903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="357" mass="40985" checksum="1C6E3AF668CD6BB7" modified="2024-07-24" version="1" fragment="single">VWMMPREQAAALVQDYVDHVYPLLPAIHGPTTQNQVMDFYARLSRGEQIEPRLAALILGIGAVSAYFWQPDAAHHSRFASAEEAAQASFAWRKWAYDILTEAQGSSRNSTLEDLQAWTLLSFMVHNVDGCSYRFRFLHNCALNAARELKVHLVDSPRAETKDNRVSREVKRRIWWQLVGTDWMLGFMGGPTEGTYSIHPRHMNVKYPRNLNDNDIATWDESTTAPLNVHTQMSFSLQRIRIAEIARSILDARQPGSPEVDVTDYNQVLALDRLFEQAFIDLPPFYHLHYGSPFHPERDSSLELQRVLVQLGLLSRRARLHRPFLLQGNRDDPRHQQCREICLQSTRTAVSISISIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M5N0</accession>
    <name>A0AAJ0M5N0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_386405</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725565.1">
        <property type="nucleotide sequence ID" value="XM_062864322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M5N0"/>
    <dbReference type="GeneID" id="87883151"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF19">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01812)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="338"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="455"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="51"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3309785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="512" mass="57437" checksum="6A210F10472F68F8" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M5S6</accession>
    <name>A0AAJ0M5S6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl transferase/acyl hydrolase/lysophospholipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_407004</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable lipid hydrolase.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725921.1">
        <property type="nucleotide sequence ID" value="XM_062865320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M5S6"/>
    <dbReference type="GeneID" id="87884149"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07229">
        <property type="entry name" value="Pat_TGL3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021771">
        <property type="entry name" value="Triacylglycerol_lipase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF44">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11815">
        <property type="entry name" value="DUF3336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="8">
        <location>
            <begin position="230"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="606"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3310141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="627" mass="70508" checksum="70BF73F58786D7E6" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M651</accession>
    <name>A0AAJ0M651_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Non-histone chromosomal protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_489006</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA-binding protein that induces severe bending of DNA. Required for DNA-binding by the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. Also augments the fidelity of transcription by RNA polymerase III independently of any role in the FACT complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NHP6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726104.1">
        <property type="nucleotide sequence ID" value="XM_062866562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M651"/>
    <dbReference type="GeneID" id="87885391"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01390">
        <property type="entry name" value="HMG-box_NHP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000016">
        <property type="entry name" value="FACT complex subunit SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF22">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION FACTOR A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="8">
        <location>
            <begin position="25"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="6">
        <location>
            <begin position="25"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="69"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00057588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00067275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3310324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="104" mass="11791" checksum="86FF846D824BB8A7" modified="2024-07-24" version="1">MPKQAKGKSGKVEKQRRAKKDPNAPKRGLSAYMFFANEQRENVREENPGVSFGQVGKILGERWKALSEKQRAPYEAKAAADKKRYEDEKQAYNAQAEADEEESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M655</accession>
    <name>A0AAJ0M655_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Actin binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_387196</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726119.1">
        <property type="nucleotide sequence ID" value="XM_062864368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M655"/>
    <dbReference type="GeneID" id="87883197"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11281">
        <property type="entry name" value="ADF_drebrin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11962">
        <property type="entry name" value="SH3_Abp1_fungi_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11961">
        <property type="entry name" value="SH3_Abp1_fungi_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000242">
        <property type="entry name" value="Actin binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000273">
        <property type="entry name" value="Actin binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000045">
        <property type="entry name" value="Actin binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035719">
        <property type="entry name" value="Abp1_fungi_SH3_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035718">
        <property type="entry name" value="Abp1_fungi_SH3_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829">
        <property type="entry name" value="CORTACTIN AND DREBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829:SF25">
        <property type="entry name" value="DREBRIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="ADF-H" evidence="5">
        <location>
            <begin position="5"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="640"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="734"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="157"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="311"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="703"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="601"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="707"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="724"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3310339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="792" mass="82818" checksum="153D224C6E569BD8" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M688</accession>
    <name>A0AAJ0M688_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_489084</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the engrailed homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726180.1">
        <property type="nucleotide sequence ID" value="XM_062866567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M688"/>
    <dbReference type="GeneID" id="87885396"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050720">
        <property type="entry name" value="Engrailed_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24341">
        <property type="entry name" value="HOMEOBOX PROTEIN ENGRAILED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24341:SF6">
        <property type="entry name" value="HOMEOBOX PROTEIN INVECTED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="60"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="62"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="108"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="350"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="612"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="117"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="386"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="620"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="636"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3310400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="654" mass="70321" checksum="7F454452113DEFA1" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M6L3</accession>
    <name>A0AAJ0M6L3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">enoyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="11">1.3.1.104</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0T15DRAFT_519428</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 2,3-saturated acyl-[ACP] + NADP(+) = a (2E)-enoyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22564"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.104"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.104" evidence="11"/>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726555.1">
        <property type="nucleotide sequence ID" value="XM_062868430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M6L3"/>
    <dbReference type="GeneID" id="87887259"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141148">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08290">
        <property type="entry name" value="ETR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000112">
        <property type="entry name" value="Enoyl-[acyl-carrier-protein] reductase 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051034">
        <property type="entry name" value="Mito_Enoyl-ACP_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43981">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43981:SF2">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="13">
        <location>
            <begin position="75"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3310775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="442" mass="47681" checksum="E8F44723615E3804" modified="2024-07-24" version="1">MASVLGRPSPLRLGLVARRTTTTTNTIAATASGSRVLSPFLPSSTHNCYPRRYKSGPYGYTLAKTLVFSRFGEPKDVLSLHTHSISPTLPDGAVLLRALAAPVNPADVNTIQGTYGAKPSFSPLLGTPEPAAVPGNEGCFEVVSVGAQTPGLARGDWVIPATSGFGTFRTHALVEDAARQLIRIGGEKGTEGLSAKQVATVSVNPCSAYRMLKDYVDLVDLSVKSFARGGDGATGGAWFLQNGANSGVGRSAIQLGRLWGLRSINVIRERATPEETEALKKELQELGATVVVTEDEFLDRSFSARLKEEWTRGGREPVLLGLNCVGGKSASAMVKALSPGGCMVTYGGMSRQSFPFPTGPQIFKRLRFEGFWLSEWAKEHPTEKRNTINEILEHMRNGRFKEAPFQEVEWGWDTEEKVLKDAVQGTLEGFRSGKGIFVFGDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M761</accession>
    <name>A0AAJ0M761_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SMP-30/Gluconolactonase/LRE-like region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_521869</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727346.1">
        <property type="nucleotide sequence ID" value="XM_062868583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M761"/>
    <dbReference type="GeneID" id="87887412"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052988">
        <property type="entry name" value="Oryzine_lactonohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47064">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G08990)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47064:SF2">
        <property type="entry name" value="SMP-30_GLUCONOLACTONASE_LRE-LIKE REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042610950" description="SMP-30/Gluconolactonase/LRE-like region domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="2">
        <location>
            <begin position="219"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3311566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="430" mass="46824" checksum="7CE70C74B61DEC71" modified="2024-07-24" version="1">MAFLRSPLVGAVLVQLLSTSNPGWPASGLGVTALPKEDTIPSQAQIIDQRSFNVFYTVAPPHHHDGFTQFVPPETTEASLVARPFHIYDEGFLDIIGDNPTLTLLNHTTEDPIFHEAPVWYPAKDEMFFVQNAGSPAAGTGLAKSAIIQKISLSAITTDITSKMNASGSIEVEVVNSDPMVMNPNGGTNYRGQILFLGEGQGDHIAPAMYLMNPESPYNTTVILDNFFGRQFNSLNDVSINPRNGEIYFTDPTYGYFQWFRPEPGLPKQVWRFNEATGAVTVAADGFDSPNGIVFSPTGSHVYVADSGMTHVFYGNDFTRPATIYRYDVNDDGTLDNRKTFAYVTPVVPDGMHVDTKGNLYVGCGDGVQVYNPSGKLLGKIYLGGTSANFQFAGKGRMVILAETKLYYATLAAEGAFPGKLYQKDQGCEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M781</accession>
    <name>A0AAJ0M781_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphoadenylyl-sulfate reductase (thioredoxin)</fullName>
            <ecNumber evidence="3">1.8.4.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">3'-phosphoadenylylsulfate reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">PAPS reductase, thioredoxin dependent</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">PAdoPS reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0T15DRAFT_73795</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[thioredoxin]-disulfide + sulfite + adenosine 3',5'-bisphosphate + 2 H(+) = [thioredoxin]-dithiol + 3'-phosphoadenylyl sulfate</text>
            <dbReference type="Rhea" id="RHEA:11724"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="EC" id="1.8.4.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PAPS reductase family. CysH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.8" evidence="3"/>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727182.1">
        <property type="nucleotide sequence ID" value="XM_062871268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M781"/>
    <dbReference type="GeneID" id="87890097"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004604">
        <property type="term" value="F:phosphoadenylyl-sulfate reductase (thioredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019379">
        <property type="term" value="P:sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23945">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000151">
        <property type="entry name" value="Phosphoadenosine phosphosulfate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00063">
        <property type="entry name" value="CysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004511">
        <property type="entry name" value="PAPS/APS_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011800">
        <property type="entry name" value="PAPS_reductase_CysH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00434">
        <property type="entry name" value="cysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02057">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002537">
        <property type="entry name" value="PRK02090.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46509">
        <property type="entry name" value="PHOSPHOADENOSINE PHOSPHOSULFATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46509:SF1">
        <property type="entry name" value="PHOSPHOADENOSINE PHOSPHOSULFATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000857">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoadenosine phosphosulphate reductase" evidence="14">
        <location>
            <begin position="72"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00078053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00082553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3311402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="299" mass="33851" checksum="C5D3264926CC625B" modified="2024-07-24" version="1">MADDSRAETSSQLSSNTDHGSVDSGFVSGNTSTVSLPRISITRPHLDHLNKQLESLHPMDILRFSKIFFPNLYQSTAFGLTGLVTIDMLSKINADSPSPQPVDLIFLDTLYHFEETYDLVERVKARYNVHVHVFKPADVETVSQFEELYGEKLYETSSELYDWIAKVEPLQRAYSELKVAAVLTGRRRSQGGQRGDIKVIELDEERGVVKINPFANWTFTQVKAYIDEHNVPYNALLDRGYKSVGDWHSTVPVGEGEDERAGRWKGQDKTECGIHNKQSRYAQWLAQNARQKAQEVQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GLC6</accession>
    <name>A0AAJ0GLC6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WSC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_404504</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717790.1">
        <property type="nucleotide sequence ID" value="XM_062865256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GLC6"/>
    <dbReference type="GeneID" id="87884085"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051589">
        <property type="entry name" value="Sialate-O-sulfotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45964">
        <property type="entry name" value="WSCD FAMILY MEMBER CG9164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45964:SF5">
        <property type="entry name" value="WSCD FAMILY MEMBER CG9164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042532481" evidence="3">
        <location>
            <begin position="17"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="4">
        <location>
            <begin position="30"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="4">
        <location>
            <begin position="134"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="240"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="385"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="242"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="397"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3302010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="573" mass="61225" checksum="60D2158B4F54C2DC" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GLG1</accession>
    <name>A0AAJ0GLG1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ribosomal protein L23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_541895</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717863.1">
        <property type="nucleotide sequence ID" value="XM_062869896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GLG1"/>
    <dbReference type="GeneID" id="87888725"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000035">
        <property type="entry name" value="60S ribosomal protein L23a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_A">
        <property type="entry name" value="Ribosomal_uL23_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_uL23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005633">
        <property type="entry name" value="Ribosomal_uL23_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011118">
        <property type="entry name" value="PRK14548.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L23A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03939">
        <property type="entry name" value="Ribosomal_L23eN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL23 N-terminal" evidence="7">
        <location>
            <begin position="17"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3302083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="156" mass="17130" checksum="10552C8C236C5ABE" modified="2024-07-24" version="1">MAPKDNKKGGASKAGKGAQAKKAAQAALKGVHSHKKTKVRHTTTFHRPKTLVLSRAPKYPRKSIPHAPRLDEHKIIVHPLNTEGALKKIEEQNTLVFIVDVKANKAQIKQALKKLYDIDTVKINTLIRPDGSKKAFARLTPDVDALDIAATKLNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GLK1</accession>
    <name>A0AAJ0GLK1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sin3 associated polypeptide p18-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_295579</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717963.1">
        <property type="nucleotide sequence ID" value="XM_062863759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GLK1"/>
    <dbReference type="GeneID" id="87882588"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.550">
        <property type="entry name" value="ASAP complex, SAP18 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010516">
        <property type="entry name" value="SAP18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042534">
        <property type="entry name" value="SAP18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13082:SF0">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13082">
        <property type="entry name" value="SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06487">
        <property type="entry name" value="SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="154"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3302183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="250" mass="26563" checksum="D7F8D4823A82B432" modified="2024-07-24" version="1">MSTPELKRDETPPFLVKLFYRTGAFHRPDEFNTPSLPPHLTIHTWKDCTLTELSHHMVGASPPILPDPAIGTRLAFRLIYADTRARLDVPPRYVAKDLGSLVLGGGGPGAGPDEGFAGDEPDDGAKTLADARFITGDYISCAILPPNELTGDVAPASSARMGRGAGVGEARGLTGAPPPPPASRERDYGPPGGLRGRGIRGGGTRGYGGRRYGDRDEPFLRGGGGMPQGEWRRGDMLSEDEPSGPARWGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GLQ6</accession>
    <name>A0AAJ0GLQ6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">TLC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0T15DRAFT_542406</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingosine N-acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718028.1">
        <property type="nucleotide sequence ID" value="XM_062869918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GLQ6"/>
    <dbReference type="GeneID" id="87888747"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF11">
        <property type="entry name" value="CERAMIDE SYNTHASE LAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="268"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="315"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="370"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="12">
        <location>
            <begin position="183"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="407"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3302248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="449" mass="51472" checksum="6C84D69F1B7A962B" modified="2024-07-24" version="1">MAGGTEPFPPLTSAADRQLHSEANATRRRRKSSILGTELRVGDTGAPSIATGIAHLNGIAKEPMTSPATPSKRFSKRRKARSALRRAKNIAVKHTWVIPLVILLVFLSLYAMNPSESNPVHHFLFLSYKLPQTESDERPQYGKGLWDVAFVSFYTVVLSFTREFIMQEILRPMARWAGLRSRGKQARYMEQMYTALYFGIMGPVGVWVMSRTPVWYFNTRGMYENFPHMTHDAAFKFYYLFQAAYWAQQAIVLLLGMEKPRKDFKELVCHHIVSLALIGLSYRFHFTYMGLAVYITHDISDFFLATSKTLNYLDHWLTGPYYFTFMCVWIYLRHYLNLRILFSLFTEFRTVGPFELNWETQQYKCLLSQVITLALLSALQALNLFWLFFIIRIAYRFVVHNVAKDDRSEPEESEAEEANGAPLVANGKAKSTALTPNGAANGVAKKSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GLS8</accession>
    <name>A0AAJ0GLS8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_496776</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPRTase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="4"/>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718086.1">
        <property type="nucleotide sequence ID" value="XM_062867209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GLS8"/>
    <dbReference type="GeneID" id="87886038"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000049">
        <property type="entry name" value="Putative uracil phosphoribosyltransferase urg2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050054">
        <property type="entry name" value="UPRTase/APRTase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001097">
        <property type="entry name" value="PRK00129.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315:SF4">
        <property type="entry name" value="URACIL PHOSPHORIBOSYLTRANSFERASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="6 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="10">
        <location>
            <begin position="10"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3302306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="226" mass="23865" checksum="1E6DFDF03E6D5EB7" modified="2024-07-24" version="1">MSNLPPNVHVSQHPCLLAKLSQLRSKGTAARDVKALIHDITLIVGCEALAKGLTSVSGPTDQTPLGFEYETRHVQPSAVSLVPILRSGLGMVEAIQTLLPDPVPVHHLGLYREPVTLSPVEYYNNLPNHLSSGAGSVSNLTVILDPVIATGGTCAAAIETLREWGTRRIIVISVLGAAPGVKAAADVWPEGVEIWLAGVDPELTDRGMIKPGIGDVGDRLFLTIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GM17</accession>
    <name>A0AAJ0GM17_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 20">Serine/threonine-protein kinase Tel1</fullName>
            <ecNumber evidence="5 20">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">B0T15DRAFT_505486</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17 20">Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Associates with DNA double-strand breaks.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 20">Chromosome</location>
            <location evidence="2 20">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 20">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the PI3/PI4-kinase family. ATM subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5 20"/>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718231.1">
        <property type="nucleotide sequence ID" value="XM_062867529.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87886358"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05171">
        <property type="entry name" value="PIKKc_ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000019">
        <property type="entry name" value="Serine/threonine-protein kinase Tel1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038980">
        <property type="entry name" value="ATM_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044107">
        <property type="entry name" value="PIKKc_ATM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021668">
        <property type="entry name" value="TAN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37079">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37079:SF4">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11640">
        <property type="entry name" value="TAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01342">
        <property type="entry name" value="TAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14 20" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7 20" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11 20" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16 20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 20" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="15 20" id="KW-0779">Telomere</keyword>
    <keyword evidence="9 20" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAT" evidence="23">
        <location>
            <begin position="1864"/>
            <end position="2465"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="22">
        <location>
            <begin position="2571"/>
            <end position="2887"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="24">
        <location>
            <begin position="2919"/>
            <end position="2951"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="421"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="695"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="2859"/>
            <end position="2907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="191"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="695"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00025079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU365027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KAK3302451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="2951" mass="328684" checksum="AC1A2C2B03FBFAF8" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GM32</accession>
    <name>A0AAJ0GM32_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_306593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718249.1">
        <property type="nucleotide sequence ID" value="XM_062863874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GM32"/>
    <dbReference type="GeneID" id="87882703"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3302469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="181" mass="20035" checksum="6948A6129ECEFACA" modified="2024-07-24" version="1">MDSFARLVARGSEQTDDKSSTVNLLIALLCVVLFGLLALASLVLLRRMRRQKKMMEETLPQYQDVKRTGNHRGLTIQTSGGNGRSSVIVVNGGGQPMLANPHSPPHSPDNVPEIHITFPDEQDEQGRRKSGRVVVVRVGETTVGLEPLNEEQLPAYEKESSTQFYSVDIDKIGGLKEKEFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GMB8</accession>
    <name>A0AAJ0GMB8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_514381</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718115.1">
        <property type="nucleotide sequence ID" value="XM_062868114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GMB8"/>
    <dbReference type="GeneID" id="87886943"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="287"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="39"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="143"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="168"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="296"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3302335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="305" mass="32540" checksum="9C9AE5B47B1F9860" modified="2024-07-24" version="1">MPPKTAAAPPPMAKQSTPKTMSSRLMTMKFMQRGAAVAAAAAAAGTPEAGSPVTPRTDDGSAKRRKVAHSPSAASSPATPLYDQKAIQAAIEEEEKKRKAAIEKRAAELGDSHWVLQGALTLPKTGPRALLDVVPVGFAQIDSAGTSGEADDPFDMGSMPVQPQIKRFNMKKSKACLRRRVTKAAGDRSSSSGSDSDSDSGSEEDSGDERSPVSTGEPGRGRRITLADEERKRARSSVSRRREEERRKAQQLAGKRRKKEIKLNKLTSISSAGGQDFGRPSSTTFSCHGCGKTGHKVADCPKKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GMT7</accession>
    <name>A0AAJ0GMT7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 18">Mevalonate kinase</fullName>
            <shortName evidence="18">MK</shortName>
            <ecNumber evidence="3 18">2.7.1.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">B0T15DRAFT_568650</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Mevalonate kinase; part of the second module of ergosterol biosynthesis pathway that includes the middle steps of the pathway. The second module is carried out in the vacuole and involves the formation of farnesyl diphosphate, which is also an important intermediate in the biosynthesis of ubiquinone, dolichol, heme and prenylated proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>(R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17065"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:58146"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.36"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="17 18">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 18">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 18">Belongs to the GHMP kinase family. Mevalonate kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.36" evidence="3 18"/>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3302886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718666.1">
        <property type="nucleotide sequence ID" value="XM_062870778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GMT7"/>
    <dbReference type="GeneID" id="87889607"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004496">
        <property type="term" value="F:mevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.890:FF:000003">
        <property type="entry name" value="Mevalonate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006205">
        <property type="entry name" value="Mev_gal_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00549">
        <property type="entry name" value="mevalon_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43290">
        <property type="entry name" value="MEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43290:SF2">
        <property type="entry name" value="MEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00959">
        <property type="entry name" value="MEVGALKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 18" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 18 21" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 18" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="14 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 18" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="16 18" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="13 18" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="15 18" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="6 18" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="19">
        <location>
            <begin position="125"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="20">
        <location>
            <begin position="305"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU363087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAK3302886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="445" mass="48713" checksum="0E988AC71EFD61E7" modified="2024-07-24" version="1">MERKISSPMAPTFMVSAPGKVIVFGEHAAVFGKPAVAAAISLRCYLLVTTFSKYRFLNHTWTIDTLPWPVFHHVSKKKFYYSVVDSLDPELLDAIRPHAEAVSRDLSKKQREMHVQSATAFLYLFLSLGSPQSPGFVYTLRSTIPIGAGLCSSASVCVCLSTALLLQTRTLTGPHPDQPLKEAEVQIERINHWAFVGELCIHGDPSGVDNTISSRGKAVLIQKSTSGAPSVTPLVNFPKLRLLLVDTRQPRSTATQVEKVRRLKDNHPTTIDLVLDAIGQLTASALELLSSANFNGNGTCDALDRLGMLTRMNHGLLDALGVSHPRLQRVCELVEHSGVGWAKLTSAGGGGCAITLLRPDVKEETLEELERRFTAEGFQKYDAILGADGVGVLWPAVFRNGSARENGEEIDQEKFENAIGAWGIEQLVGVGEDREGWRFWTRADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GMV0</accession>
    <name>A0AAJ0GMV0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyl transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_568643</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3302877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718657.1">
        <property type="nucleotide sequence ID" value="XM_062870777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GMV0"/>
    <dbReference type="GeneID" id="87889606"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46830:SF2">
        <property type="entry name" value="ALPHA-1,4-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46830">
        <property type="entry name" value="TRANSFERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3302877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="357" mass="40746" checksum="CB524CCA27BE6FA2" modified="2024-07-24" version="1">MPMFTQGRTRLDLSPPPPACTNRAPDDDVIPNQVHFVYILKNTSHDFNFEFSHFLSIYAAWHYWRPQAIYLHTNVAADSRSVARARNGTAGKWNHYIFTFFNLTVHEVDVPTHAGNGVELQNIEHKSDFVRVKALYELGGVYIDFDVHPLRNIRPLRESGFRAIAGRQLGGQINSGTFMTARGGKLARLWMEQMHVAYTGGWTTHSNEVITRVGQRLVREPGEMLIMEQDAFAPGSWKDEDTDALFAVHGDAPSNLPPNDTSATTDVKLDLPSHDEAFADRWDHPERFPEWERDWSHTYLLHAFTPDRWHHKVPGFDHITPRYVLERRSNFARAVYPVAKVLLDQGLIGVEDSHTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GND6</accession>
    <name>A0AAJ0GND6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_264647</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="2"/>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718909.1">
        <property type="nucleotide sequence ID" value="XM_062863384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GND6"/>
    <dbReference type="GeneID" id="87882213"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010605">
        <property type="term" value="P:negative regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043634">
        <property type="term" value="P:polyadenylation-dependent ncRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045862">
        <property type="entry name" value="Trf4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092:SF15">
        <property type="entry name" value="INACTIVE NON-CANONICAL POLY(A) RNA POLYMERASE PROTEIN TRF4-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092">
        <property type="entry name" value="POLY(A) RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="7">
        <location>
            <begin position="449"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="6">
        <location>
            <begin position="649"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="208"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="774"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="239"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="802"/>
            <end position="813"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3303129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="813" mass="91673" checksum="EBFFF53E122B7B33" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ0GNJ6_9PEZI</name>
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        <recommendedName>
            <fullName evidence="2">CR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_504464</name>
    </gene>
    <organism evidence="3 4">
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        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718996.1">
        <property type="nucleotide sequence ID" value="XM_062867498.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87886327"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="1"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3303216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719222.1">
        <property type="nucleotide sequence ID" value="XM_062863505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GNX9"/>
    <dbReference type="GeneID" id="87882334"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
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        <location>
            <begin position="335"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3303442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="346" mass="36325" checksum="679456726D401B96" modified="2024-07-24" version="1">MATSTSVLATTTSPTPLVITSFPTIPLTTTFTRPNEGCGGIYLPDDPPLFMIDDRPSCLPSRFSTSDSSFFYSPGIACPSGYWTACYDTTGVSSITTVTCCPTYGDIKLSCVADPLTLSSVWETLFCTWVAPAETGTVITTTERRGKTSVGTAQVTAPGGINAYGVRMVYQSTDLYTSTSTSSSSSASDTTDTAAPSTTASPGDPPAISGSASSSADSSSGLSTGAKAAIGVVIPLVVIGALILGLLFWRRRKQQVLPLSPEQEYAATAATASVAPPDEHHQLTEQPKLPVYYYGSPPQPTQPHPHEMPGTYYLPEMPSARQAAAELPADPTEPTPTYTSYYGYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GP62</accession>
    <name>A0AAJ0GP62_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_279400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719347.1">
        <property type="nucleotide sequence ID" value="XM_062863558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GP62"/>
    <dbReference type="GeneID" id="87882387"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3303567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="205" mass="22967" checksum="830E6C3C4BFF1339" modified="2024-07-24" version="1">MLLVSGRCKPGMSPTPPSYTTCPLQCSLRAQVLLQFILRDLSPTRYRSAALVFTMPDWEDYSTPRVVLAARSEIENQGCRTHGGVGIFQKIVTVSFRGHTSLRLSDKAERNGSVMFSARRRRYVDSIWFNRGPLILNLHWLRARGVTGRWRSSTGDADSLQSRVNPLRRNCPGDSRNVRVRQEAGHWSGNGPGTGTPDTTPRDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GPD2</accession>
    <name>A0AAJ0GPD2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HORMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_281785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719452.1">
        <property type="nucleotide sequence ID" value="XM_062863587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GPD2"/>
    <dbReference type="GeneID" id="87882416"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3303672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="595" mass="66074" checksum="EA65D165387008B4" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GPL3</accession>
    <name>A0AAJ0GPL3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_487116</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polyketide transferase af380 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719582.1">
        <property type="nucleotide sequence ID" value="XM_062866413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GPL3"/>
    <dbReference type="GeneID" id="87885242"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051411">
        <property type="entry name" value="Polyketide_trans_af380"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47751:SF2">
        <property type="entry name" value="DLTD N-TERMINAL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G00380)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47751">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G16580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="57"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3303802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="304" mass="34245" checksum="B8D4CD2463640735" modified="2024-07-24" version="1">MADSAPPRLDADIKTLDGTTLRGWLFPAASRGPAMIMTPGFNFPKDANLPDIAKWFQEHGVTTLLYDPRGIGASEGEPRNEVDPRQQIEDLHDIVTWLKEHPLVDEAKIALWGLCWGGNVTLAATAFEYVRNDSAQTKRVAATIAMAPMINTDGSPERRKPLLELAMHDRTSQLLSGQSPMYLPYIDEDGNMPNGQEMAPEIVPALERLGIALENRISVQTYYKCLAWNLLHVVKYVAPTPAMMVSPELDETSPLDSQLHCFTQMGYPKELDILKGSGHLDWMFKDLEQILRRQFDFLKKYMEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GPR2</accession>
    <name>A0AAJ0GPR2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_561280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719616.1">
        <property type="nucleotide sequence ID" value="XM_062870552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GPR2"/>
    <dbReference type="GeneID" id="87889381"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF410">
        <property type="entry name" value="LYSINE-SPECIFIC HISTONE DEMETHYLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="1">
        <location>
            <begin position="57"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3303836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="397" mass="43516" checksum="E0324E4B7DA57D4B" modified="2024-07-24" version="1">MINPPGHRSRDGFQWTREGGLQAGIPSLGVIKPTNNLSPAGTNDAVFDVIVVGGGYTGLTAIRDLALAGHRVLLPEARDRIGGRSWSSNIDGYPYELGGTWLFRYGMSSALEISMVTESGLNKCFVDMGSNRLEMSHEREDIPSESALIKYIDVDGHLARTVIPFPHDPHYDKEAVAHYDAMSMADRLAEIADELTPVEYSMLEQFLAVTCGSGRFEDASFFEVLRWWALMNYSYRDFIALGLTYKLRHGQPALARGFFDEALATGNLRRSSSNSSSSSAGTGTTATFRAHRVICTVPLNVLYKIDFSPPLSQAKSEASKLGHVNQVAKCHAELGHPELRSVTAFSRDAKLTYGFGDGTTPAGNTHPEEDIQETLQAWRDLIVGRNTPGTTMMEGVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GPS6</accession>
    <name>A0AAJ0GPS6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_281634</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719440.1">
        <property type="nucleotide sequence ID" value="XM_062863581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GPS6"/>
    <dbReference type="GeneID" id="87882410"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053002">
        <property type="entry name" value="Metalloproteinase_M10B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021917">
        <property type="entry name" value="Unchr_Zn-peptidase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21054:SF2">
        <property type="entry name" value="MIP04191P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21054">
        <property type="entry name" value="ZINC METALLOPROTEINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12044">
        <property type="entry name" value="Metallopep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="659"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="661"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="693"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3303660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="722" mass="79684" checksum="41BC0E7C7B369047" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQ26</accession>
    <name>A0AAJ0GQ26_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_485833</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719843.1">
        <property type="nucleotide sequence ID" value="XM_062866315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQ26"/>
    <dbReference type="GeneID" id="87885144"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057683">
        <property type="entry name" value="DUF7923"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057654">
        <property type="entry name" value="Znf-CCCH_tandem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37543">
        <property type="entry name" value="CCCH ZINC FINGER DNA BINDING PROTEIN (AFU_ORTHOLOGUE AFUA_5G12760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37543:SF1">
        <property type="entry name" value="CCCH ZINC FINGER DNA BINDING PROTEIN (AFU_ORTHOLOGUE AFUA_5G12760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25540">
        <property type="entry name" value="DUF7923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25542">
        <property type="entry name" value="zf-CCCH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25543">
        <property type="entry name" value="zf-CCCH_tandem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="4">
        <location>
            <begin position="376"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="376"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="338"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="40"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3304063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="470" mass="51883" checksum="A63DCACF7953905B" modified="2024-07-24" version="1">MAEFVRRYQSLSAHRDSQEELIKDLILYSESVESSLRAENTNLMSRLRDAELDLEDATRSRRELQQQIQQLEAYHEAALQDSYLKNSNPYVTVLIDGDCLLFKESLIGQGIEGGKKAAYALRAAILEQCGSHASSIEIIAKVYANLAGLCRAMRRDGCSSNESDLKDFSLGFTQAKASFDFVDVGHGKERADNKIRETTKWHLRNSNCKQVILGISHDAGYAPFLDELFQDASLRVRVTVLEGFPTVRELVATGVNILNLNDRLFRSEKLVDKVSLGPTLIPAPSDVRGVAASVTSASILTPSTSIASTPAQVSATTYARAIKNATPPPQITLPMQLKPATASARPSQQPQNPGPRGLDPPLLVSQTALDTIKKRRDNHKLCNNHYLRGPCTKGSACMFEHDYKPTRDELVAIAFLTRLNPCSKGQECDIPDCIYGHHCPSVRDGACTHPFCRFAKEDHPPGTKLRVHRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GR46</accession>
    <name>A0AAJ0GR46_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase</fullName>
            <ecNumber evidence="4 14">2.4.1.131</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B0T15DRAFT_537098</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes, on the cytoplasmic face of the endoplasmic reticulum, the addition of the fourth and fifth mannose residues to the dolichol-linked oligosaccharide chain, to produce Man(5)GlcNAc(2)-PP-dolichol core oligosaccharide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>an alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + 2 GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + 2 GDP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:29523"/>
            <dbReference type="Rhea" id="RHEA-COMP:19515"/>
            <dbReference type="Rhea" id="RHEA-COMP:19516"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:132511"/>
            <dbReference type="ChEBI" id="CHEBI:132515"/>
            <dbReference type="EC" id="2.4.1.131"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12 14">
            <dbReference type="Rhea" id="RHEA:29524"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.131" evidence="4 14"/>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720407.1">
        <property type="nucleotide sequence ID" value="XM_062869598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GR46"/>
    <dbReference type="GeneID" id="87888427"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004377">
        <property type="term" value="F:GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03806">
        <property type="entry name" value="GT4_ALG11-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000168">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Alg11), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038013">
        <property type="entry name" value="ALG11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031814">
        <property type="entry name" value="ALG11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45919">
        <property type="entry name" value="GDP-MAN:MAN(3)GLCNAC(2)-PP-DOL ALPHA-1,2-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45919:SF1">
        <property type="entry name" value="GDP-MAN:MAN(3)GLCNAC(2)-PP-DOL ALPHA-1,2-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15924">
        <property type="entry name" value="ALG11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="ALG11 mannosyltransferase N-terminal" evidence="16">
        <location>
            <begin position="126"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="15">
        <location>
            <begin position="376"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00056799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF15924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK3304627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="575" mass="63889" checksum="950137EE17D615DF" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GR70</accession>
    <name>A0AAJ0GR70_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_250192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720438.1">
        <property type="nucleotide sequence ID" value="XM_062863161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GR70"/>
    <dbReference type="GeneID" id="87881990"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053226">
        <property type="entry name" value="Pyrrolopyrazine_biosynth_F"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48419">
        <property type="entry name" value="SULFOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48419:SF1">
        <property type="entry name" value="SULFOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3304658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="381" mass="42502" checksum="A11061769B889A55" modified="2024-07-24" version="1">MATTTTSSSSAPANGTAPHPHRLLLVSAPRTASNLLVKILNIHQQPNVLTNDKGGYFFFDAYTSGIGNERFKTPLNQWPEEWRTELRNLYQQSLDKLEEWSARAAAENKIMFSKEHSFLFLNPAILFAPPGGGDDASSSSEPMSKEEEFFRLRIPATERYGGGAQQQTWSAGNRTVLSDEYLRTWQMAFLIRHPALAFPSMFRAVTRMTREGILNEDGVRGSSPNSTLTLRWTRMLFDWCAAQAQTSNNNNGDAAAAAAMMPLLLDAHDVIHNPNVVLRFAEAAGLDKDAVQFEWNAEEKKLDWGLIGNNDFGARSQAIMLSTLQNSTGIVKEKAPDVIDIKAEAEKWKEEFGPEVGGMIEKAVLDAMPDYEYLREKRVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GS14</accession>
    <name>A0AAJ0GS14_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tyrosinase copper-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_188054</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720841.1">
        <property type="nucleotide sequence ID" value="XM_062862408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GS14"/>
    <dbReference type="GeneID" id="87881237"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="2">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3305061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="431" mass="49053" checksum="74A8631D3ABDA0B9" modified="2024-07-24" version="1">MNHDKGSYRNFVQSRCQTNPCVTGLAEYLRCRPGAASTIVTLDYPRSGQSAPNPRTVAQVDLAELIDTTPTTAGRILLVENIQPHLISLLGEILDVDPIFFAGHVTTDFQDIEKAPLPPSLAFFPSQIAEKGYLHLHYQQVLDLRSSGAFKSSSYSLKSDSNVPRNVRRLPHLSGRQLALARACCSILVKKIKDSWICLVLVDPPIKMVVETLGSGGRKSHPSMLLHGGFEDFGHSTSFASFGSVSSDRLPDKKSMLSDLLHYFRHQPPGFMVAKPRTLSLGYYPIRIVLAEWILYIHVTSRYFKYYEYSLHDIENRLHDGDIIDLQRWRRRYLQSRHKLILLSEFIDYWLQQEADKQPWVSVQKDIKHMLSQLEQYSRSLEHMVPMATSMVQLLDSRRSMLEAANVSRLTFIAVVFVPLSWVASLFSMCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GS89</accession>
    <name>A0AAJ0GS89_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_555146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720992.1">
        <property type="nucleotide sequence ID" value="XM_062870381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GS89"/>
    <dbReference type="GeneID" id="87889210"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3305212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="147" mass="16798" checksum="4EFAE2616010C772" modified="2024-07-24" version="1">MSSRGQPNPPGTDVLLITVMSIRQKEEATKANLAHMERQLAEMQRKNKSPSEKNPIKRRIARLRTERDQWPETIADVLTHWLLSLPSDPSGPLPTLPQEVKNQIPASLSNTRIARIEQEAYKKIQEKMKEEAAHNAQRSSHSSRRYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GSF2</accession>
    <name>A0AAJ0GSF2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GPI anchored cell wall protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_193015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721082.1">
        <property type="nucleotide sequence ID" value="XM_062862465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GSF2"/>
    <dbReference type="GeneID" id="87881294"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042526353" description="GPI anchored cell wall protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3305302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="19795" checksum="E08B151CF344A8BD" modified="2024-07-24" version="1">MRSFTTTLAAAATLASLVVAQNNSVNMFIEDGINGQGLYAASIISACKDQTVYALRCTSARDDDIKPTICGPDVSALTVTAGPSVYMVSYVTETSAGGHEAAVSVFESCSLQGTTAASCFATGAIEIDDRATATSFSTVLSGADYHRYQVAITGGAEKTASATGECKPNAGAGTHPNVVRAVGASLAIGLLGVLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GSN8</accession>
    <name>A0AAJ0GSN8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_567343</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721189.1">
        <property type="nucleotide sequence ID" value="XM_062870724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GSN8"/>
    <dbReference type="GeneID" id="87889553"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
    </dbReference>
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        <property type="entry name" value="MFS_dom"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF33">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="573"/>
            <end position="593"/>
        </location>
    </feature>
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            <begin position="87"/>
            <end position="602"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3305409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="604" mass="64556" checksum="6CDB60B893985959" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
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        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3306053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="214" mass="23669" checksum="9329786C7FAD2433" modified="2024-07-24" version="1">MRWRIAFPSRSRARPHLEAHACSRSIRYKDFPSPHISACFDKPVSEKTMAHRPPGPRCPKETEGPDADPAQAQAEPAAVAAFELPEPESISGWDKLPRLPQNTEPRYKGILTALVMAIEQIPPCIYVVNLHTEPIRWWYPSTVQGIEASSNGPSTSHSVFRFGYSRLPTGGSVMLKEMMDEGCGLSLPVFMANLIVALTAATFGFPLLLWSVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GU27</accession>
    <name>A0AAJ0GU27_9PEZI</name>
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        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_215158</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721745.1">
        <property type="nucleotide sequence ID" value="XM_062862724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GU27"/>
    <dbReference type="GeneID" id="87881553"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF19">
        <property type="entry name" value="MEMBRANE PROTEIN PTH11-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14080)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="39"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="284"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="418"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="292"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="371"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="437"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3305965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="453" mass="49417" checksum="6B3F51CD7F77E3A8" modified="2024-07-24" version="1">MGSSLYSSPPPPRPLSDDKPTLLTSWWITLLCAVIILFRLLGRCVRVEKLFREDLYAAAALIPLFVRMGLVHPILLYGTNNVLFDGLSPPSHIEIHRRSVASRLVLVSRLLHCAILWLLKVVTLEFFDRLVGQSGKNRYTILLRFMRASLGVTFVAVVIADLAECKPFTHYWQVLPDPGGQCRQGYAFLITMTACNVLTDLLLMVFPVPIVFKSRISKGRKALLIALFCLHIFTVVVAIYRVPKILGEDGYQATRTMWASAEILMATFAANALTLGTFMRDTGVKKKKPNRYQPTESSGARSGQRASKVTKKASWQDPDSEGDDEPAMPYGARSPRPGETAPSVAGATTPAPEGETDVPRTGSVDSLIPRTRSEAGKPDSDAKVLKTTTIEVTVAPAEDSLYSGPGETINGLVIPAVSSAGPASGWGRRRGSPIPLRHMEPLPDRDQAANGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GU75</accession>
    <name>A0AAJ0GU75_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_417327</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the NRP synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3306162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721942.1">
        <property type="nucleotide sequence ID" value="XM_062865488.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87884317"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19534">
        <property type="entry name" value="E_NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000002">
        <property type="entry name" value="Nonribosomal peptide synthase Pes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45398">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45398:SF1">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="21"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="271"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="1824"/>
            <end position="1900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2499"/>
            <end position="2599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2631"/>
            <end position="2715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2736"/>
            <end position="2780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2797"/>
            <end position="2855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2505"/>
            <end position="2528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="2643"/>
            <end position="2653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2736"/>
            <end position="2752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="2823"/>
            <end position="2834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3306162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="2855" mass="312671" checksum="BAF3F92E45005636" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GUJ8</accession>
    <name>A0AAJ0GUJ8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_527106</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722178.1">
        <property type="nucleotide sequence ID" value="XM_062868949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GUJ8"/>
    <dbReference type="GeneID" id="87887778"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF31">
        <property type="entry name" value="DUF636 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G12650)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="18"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3306398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="434" mass="47128" checksum="2FCBC00F01BE44A4" modified="2024-07-24" version="1">MAADLHLPRQLPGAYKTLTAECHCRSVHFRVTVPTSALPLPVHLCHCSICRFTHGSLCCFHAPLPKGIEPEFIAPSSLESSVTGYIHSPQAASERFFCSTCGCHIGDRDVKPDPETGKPEWRVATSIFAAHGEDTFQIRSHWMSDAATEPNLSTWLPAINSRPVHVHNPRPDDPNFPLAAAAGRQAAKPEGLPDGNDVLLAQCHCGGVRFTIPRPSAEEVADPFLSRFLRPSPTPSTTTITTEFRSKTESQSENGPCTRLTGQPTLKRVATICLCRDCRLTTGTHAVAWTAAPLRSLSPPIPPSLQGGLGMDGTMTTLKSYRSSERVRRGFCGVCGATALYALDDDDWVAPRSESEEEEKRVVEIAVGILRGSSSDDSVVAVEGWLAWRTGRLAGLETGREFDPGFADALAEGLREWGVKRHGESVSFDIPQEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GVD0</accession>
    <name>A0AAJ0GVD0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_510099</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.67" evidence="1"/>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722529.1">
        <property type="nucleotide sequence ID" value="XM_062867839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GVD0"/>
    <dbReference type="GeneID" id="87886668"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016314">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043491">
        <property type="term" value="P:phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051896">
        <property type="term" value="P:regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14497">
        <property type="entry name" value="PTP_PTEN-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051281">
        <property type="entry name" value="Dual-spec_lipid-protein_phosph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029023">
        <property type="entry name" value="Tensin_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12305">
        <property type="entry name" value="PHOSPHATASE WITH HOMOLOGY TO TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12305:SF81">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51181">
        <property type="entry name" value="PPASE_TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatase tensin-type" evidence="5">
        <location>
            <begin position="12"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="4">
        <location>
            <begin position="155"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="119"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="317"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="525"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="408"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="569"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3306749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="656" mass="70603" checksum="0D2FBDE7ACFD25FD" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GVN7</accession>
    <name>A0AAJ0GVN7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Serine/threonine-protein kinase RIO2</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Serine/threonine-protein kinase rio2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B0T15DRAFT_573894</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722792.1">
        <property type="nucleotide sequence ID" value="XM_062870940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GVN7"/>
    <dbReference type="GeneID" id="87889769"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05144">
        <property type="entry name" value="RIO2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000053">
        <property type="entry name" value="Serine/threonine-protein kinase RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000566">
        <property type="entry name" value="Serine/threonine-protein kinase rio2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000052">
        <property type="entry name" value="Serine/threonine-protein kinase RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030484">
        <property type="entry name" value="Rio2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015285">
        <property type="entry name" value="RIO2_wHTH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018935">
        <property type="entry name" value="RIO_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45852">
        <property type="entry name" value="SER/THR-PROTEIN KINASE RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45852:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09202">
        <property type="entry name" value="Rio2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01245">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO kinase" evidence="16">
        <location>
            <begin position="67"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="339"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="348"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00068353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00068837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK3307012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="403" mass="44632" checksum="02D067C5E8F09352" modified="2024-07-24" version="1">MKLDTRAMRHLTAEDWRVLTAVEMGGKNHEIVPTPLIERIARLKGGASGVHKSISALAKVGLIARMKEAKYDGYRLTYGGLDYLALHTHAARKHVYSVGSRIGVGKESDIMIVADDKGTQKVLKIHRLGRISFRTVKANRDYLKNRASGSWMYLSRLAAIKEYAFMQALREEGFPVPEPIAQSRHTIVMSLIDAMPMRQVSSVPDPAGLYAELIDLILRLAKHGLIHGDFNEFNILIREDKDAQDPDKITLTPIIIDFPQMVSMDHANAEMYFDRDVECIKRFFSRRFHFVSTTPGPFFKDAKKTVGRDGARRLDAAAEASGFTKKMAKDLEAAIREQQANSNGDAGGSEDDLEDESDEEEESGSDVGDTDDGEGRPLVIGDLVSVPLGSEEGLEKLTINDGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GVR1</accession>
    <name>A0AAJ0GVR1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">26S proteasome regulatory subunit RPN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_161591</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the proteasome subunit S2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722793.1">
        <property type="nucleotide sequence ID" value="XM_062862112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GVR1"/>
    <dbReference type="GeneID" id="87880941"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000026">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016643">
        <property type="entry name" value="26S_Psome_Rpn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002015">
        <property type="entry name" value="Proteasome/cyclosome_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041433">
        <property type="entry name" value="RPN1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040892">
        <property type="entry name" value="RPN1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01851">
        <property type="entry name" value="PC_rep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18051">
        <property type="entry name" value="RPN1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17781">
        <property type="entry name" value="RPN1_RPN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015965">
        <property type="entry name" value="26S_Psome_Rpn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="RPN1 N-terminal" evidence="7">
        <location>
            <begin position="59"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit RPN1 C-terminal" evidence="8">
        <location>
            <begin position="844"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005460"/>
        </source>
    </evidence>
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    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723016.1">
        <property type="nucleotide sequence ID" value="XM_062862190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GW53"/>
    <dbReference type="GeneID" id="87881019"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004697">
        <property type="term" value="F:diacylglycerol-dependent serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20822">
        <property type="entry name" value="C1_ScPKC1-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20823">
        <property type="entry name" value="C1_ScPKC1-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11620">
        <property type="entry name" value="HR1_PKC-like_2_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.160:FF:000004">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000103">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000014">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000034">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.160">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011072">
        <property type="entry name" value="HR1_rho-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036274">
        <property type="entry name" value="HR1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037312">
        <property type="entry name" value="PKC-like_HR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF390">
        <property type="entry name" value="PROTEIN KINASE C, BRAIN ISOZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02185">
        <property type="entry name" value="HR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00742">
        <property type="entry name" value="Hr1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46585">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51860">
        <property type="entry name" value="REM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="REM-1" evidence="17">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="REM-1" evidence="17">
        <location>
            <begin position="138"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="14">
        <location>
            <begin position="220"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="16">
        <location>
            <begin position="450"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="16">
        <location>
            <begin position="518"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="821"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="69"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="347"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="585"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="593"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="614"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="643"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="711"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="741"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="850"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK3307236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="924" mass="102953" checksum="47A6676D008E041C" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GWG0</accession>
    <name>A0AAJ0GWG0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_484525</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723168.1">
        <property type="nucleotide sequence ID" value="XM_062866229.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87885058"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000209">
        <property type="entry name" value="Polyketide synthase Pks12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF18">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="9">
        <location>
            <begin position="1"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="10">
        <location>
            <begin position="812"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="2301"/>
            <end position="2377"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="6">
        <location>
            <begin position="812"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="6">
        <location>
            <begin position="965"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1295"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1308"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="6">
        <location>
            <position position="844"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="6">
        <location>
            <position position="1030"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3307388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2390" mass="257596" checksum="A7D50CB75EF53F88" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GWK1</accession>
    <name>A0AAJ0GWK1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_554231</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723228.1">
        <property type="nucleotide sequence ID" value="XM_062870346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GWK1"/>
    <dbReference type="GeneID" id="87889175"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3307448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="275" mass="30121" checksum="CCC231DFA563423F" modified="2024-07-24" version="1">MRFNSKQLQSRDILYTVEPEIILDEQGCELVPRLTTIPASNNRLNSTRRLIDHGVDLSRYDERIGSSRPDSIELRTTYAILSAMKGLIGHRFLAIGADPEGVRYLTFVSSLTSVLRLPIQHAVPLSSTSSLSGNTILRLAAAQLIAAAIAGAFSWIRLPLYAEVSQLLPADIAVFVSFSSQESANEQTLLSALPPYCRGETVGWYRASCVANVGAIISVGYITQSARQLDLTVANIHLTHLSEEDFHQMFAEAIEAGFPDSPDRPETEFSTGLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GWX7</accession>
    <name>A0AAJ0GWX7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_554572</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723423.1">
        <property type="nucleotide sequence ID" value="XM_062870358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GWX7"/>
    <dbReference type="GeneID" id="87889187"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF282">
        <property type="entry name" value="WW DOMAIN-CONTAINING OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3307643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="336" mass="36232" checksum="9845ED482A95B341" modified="2024-07-24" version="1">MLDLQTLTAGARVTVFGSGNQRGVLFDPVKDIPSLAGKVILITGGAGDLGKQVAIELARHNPARIYIADLPRADDGDSVVRAITRDALSDSDQHAPPTPIRYLAVDLSSFESIKRAAAAFCAAEDRLDIAVLNAGIMRVRPGTTAEGYEVAFGINYLGHALLTRLLLPKLLHTAALPRGADVRVVAVSSEGHAMAPRGGILFDKLKGPCEDITYYQRYGQSKVAIIGFARELAARCPQIKTVAVHPGRIITGMAHGLRKESLLFRVTAPLSPLFCVPAAIGVRNHLWAATGPNVETGKYYEPVGVPDKETAIARDPTLSRRLWEWTEKEFENAIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GXC2</accession>
    <name>A0AAJ0GXC2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_183378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723370.1">
        <property type="nucleotide sequence ID" value="XM_062862340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GXC2"/>
    <dbReference type="GeneID" id="87881169"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042517819" description="Secreted protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3307590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="90" mass="9969" checksum="9A60F446C288BB5D" modified="2024-07-24" version="1">MLRLLLVVVSCARLSHVTSVQHCLVSHARYGALALTSGPHGMTSSYCNKSRDWQHHRHLRNEQVSSLEQDGIHVRPTIACNLSNATPQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GXE9</accession>
    <name>A0AAJ0GXE9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Uridine kinase</fullName>
            <ecNumber evidence="8">2.7.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_530724</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>cytidine + ATP = CMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>uridine + ATP = UMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16825"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.48"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the uridine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.48" evidence="8"/>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723415.1">
        <property type="nucleotide sequence ID" value="XM_062869191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GXE9"/>
    <dbReference type="GeneID" id="87888020"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004849">
        <property type="term" value="F:uridine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008655">
        <property type="term" value="P:pyrimidine-containing compound salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02023">
        <property type="entry name" value="UMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000339">
        <property type="entry name" value="Uridine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000010">
        <property type="entry name" value="Uridine-cytidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000764">
        <property type="entry name" value="Uridine_kinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004018">
        <property type="entry name" value="PRK05480.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00235">
        <property type="entry name" value="udk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00988">
        <property type="entry name" value="URIDINKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="37"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3307635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="467" mass="52031" checksum="DDDFF041514D567B" modified="2024-07-24" version="1">MPAPVPIEPEAFLNGTTDPETDSTIATRAHYAPPWADVSIIGIAGSSGSGKSTLSQAIVNKLNLPWVVILSIDSFYKSLDAESSKKAFRNEYDFDAPDAIDFDALVERLQDLKAGKRAEIPVYSFEKHARLDRTMSIYSPHVLIVEGIFALYDPRVLSLMDMKIFCEADADTCLSRRILRDQKERGRDIHGIIKQWFTFVKPNFEKYVNPQRNVADIIVPRGVENQVAMTMVVQFIQQKLLEKSARHRAALTRLEIGAQSEPLSSKVVVAKQTTQMRGMNTIIHDIDTSSEDFIFYFDRLAALLVEQALNNIPFLSSDITTPQGLTYLGLRPKGEVSAVIVLRGGAALEAGLHRCITDCKTGRMLIQSNIRTGEPELHYLVLPPDIDQHEAVLLLDAQMSSGGSALMAVQVLIDHGVKAERIVLVTYSAGRIGLHRLTKVFPGITAVIGQIVQDIEERWVEKRYFRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GXJ7</accession>
    <name>A0AAJ0GXJ7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_530959</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723490.1">
        <property type="nucleotide sequence ID" value="XM_062869205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GXJ7"/>
    <dbReference type="GeneID" id="87888034"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990275">
        <property type="term" value="F:preribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002838">
        <property type="entry name" value="Uncharacterized ATPase YjoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF132">
        <property type="entry name" value="ATP-DEPENDENT ZN PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="233"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3307710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="469" mass="52809" checksum="BE43321E35358EBA" modified="2024-07-24" version="1">MATTPPPPPPPPSRGLKPTSDETARQFFKHSSGKRINTDAIIAKTLQAEYPNLNLVIVPAWGVDLLGYASAGHASFTPVNQPHGKVPSSLIWKSYVPPARRIDGSPGGLRQDVDFAKFLYKWQDADFIVYMVDGRDGSSPYPRVLNYYLLTPDPAKADALVIAAGQWGSALHGEVWVWDGGAWTKSAELYDSIRKASWDNVILEEGMKKALIEDHQSFFDSRDTYARLKIPWKRGVIYHGPPGNGKTISIKAMMHTLYERKDPVPALYVRSFSSFMGPEYSIGQIFAKARQFAPCYLIFEDLDSLVTYNVRSYFLNEIDGLRSNDGIFIVGSTNHLERLDPGISKRPSRFDRKYYFPDPDLEQRVAYCRFWQRKLADNKDIEFPDKLCKAIAEITDGFSFAYIQEAFVAALLVIARDSNGLTGWSDSVGSEDGWVRVDDDEGDDLEDLILWIEIKKQVAILREGMDEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GXW7</accession>
    <name>A0AAJ0GXW7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_523672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723934.1">
        <property type="nucleotide sequence ID" value="XM_062868711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GXW7"/>
    <dbReference type="GeneID" id="87887540"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3308154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="127" mass="14450" checksum="D72565772DEA0278" modified="2024-07-24" version="1">MRSANLHFLQHFPFRLLQVHSTLSRYFVDFSFTWLVFFCFFHRSPSIAGPDNEWLDFLHGLCSIVGLGLCLTLVLWLQVTTHCTFYYLPRSASPAPALLGLKASGYGDEGMTCSGRRKRRVEGMARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GYB6</accession>
    <name>A0AAJ0GYB6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cyclin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_524371</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin C subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724188.1">
        <property type="nucleotide sequence ID" value="XM_062868761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GYB6"/>
    <dbReference type="GeneID" id="87887590"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20524">
        <property type="entry name" value="CYCLIN_CCNH_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20525">
        <property type="entry name" value="CYCLIN_CCNH_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031658">
        <property type="entry name" value="Cyclin_C_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16899">
        <property type="entry name" value="Cyclin_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0195">Cyclin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="4">
        <location>
            <begin position="73"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="244"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="347"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="250"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="269"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3308408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="401" mass="44198" checksum="790EED38E92C5D7B" modified="2024-07-24" version="1">MATEDARYRESSQYQLWSFSPTQLAAMREKTNAAARASIAGRLASMPPRASTPALPEFLTPAEEALLVTFNTSELLRAGDHAEMSDEIKATAAAFFRRFYVTNSIMTYPPTEMLMVALYFACKAEGVFLSITDFIKTFGRENPEEIIAGEFLLCQGLRFAIDVKHPFRALRGSIMELSALPDIEPARLAAAEHRAREILRFSPLITDAYFHYTPSQIMLAALSLADRGLAERLIAETFHYVAPPANNSGADTPASSGPDAPAPSRRSAPRSDGEDRTQIIGSHIRDKVLGTIEACRDMLSKELPERREHWTNKTVIKAQITPLRKKLNKCHDPERWNLVELQRARREQASKKADSEDGDAEDGPAGGTVEADGAVFGGPLPRDSKRRKVGKGLDDPFGPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GYH3</accession>
    <name>A0AAJ0GYH3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_524483</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724239.1">
        <property type="nucleotide sequence ID" value="XM_062868767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GYH3"/>
    <dbReference type="GeneID" id="87887596"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05327">
        <property type="entry name" value="retinol-DH_like_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF281">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14310)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3308459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="329" mass="35926" checksum="A448C8614611E3AF" modified="2024-07-24" version="1">MQSVLQSVTGLGPKPVHPDNLDGCVAVVVGGAFGIGFEVSRALANAGCRVIMVNRKQDQGEDAKATIAAESPGAQAEWVECDMGNLKQVREVFSQLAKEKLDRLDYLVLSAGINTNEFGLDADGIDRHFGVNFLGQFYVCNLLWPVLRKTARKGSQPRVVFEASEMHRGAPNNVHFASLEEINDSNLGPTELYARTKLAMILFAKYGLAGKVIKENEDDIIATTVHPGAVNTAMQQQWKDAYPGITGKLLTWAMLAFGRDVKQGAYSALWALTSDKVQNGWYYNDPDQPGKESAQASDEKLGIALWDLSHRIIKEKLGEDALADWNACA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GYM9</accession>
    <name>A0AAJ0GYM9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_109693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724309.1">
        <property type="nucleotide sequence ID" value="XM_062861485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GYM9"/>
    <dbReference type="GeneID" id="87880314"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="541"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="563"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="588"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3308529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="673" mass="73592" checksum="37255828085B5B40" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GYY6</accession>
    <name>A0AAJ0GYY6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aryl-alcohol dehydrogenase Aad14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_108327</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724240.1">
        <property type="nucleotide sequence ID" value="XM_062861461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GYY6"/>
    <dbReference type="GeneID" id="87880290"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF2">
        <property type="entry name" value="ARYL-ALCOHOL DEHYDROGENASE AAD10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="34"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3308460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="387" mass="42413" checksum="2A50742791847F96" modified="2024-07-24" version="1">MAGFAPPPMPPDPPTELGRLRILSKTAGIRVSPLALGGGNIGQAWNASWGVMTKERSFELLDAYLEAGGNFIDTASTYQDGESEVWIGEWMAARKVRDRLVVATKYTSDFGMYDFANPGVQKGQKANHGGNSRRSLHMSVRQSLRRLQTDWIDILYVHWWDYTTSVEEVVDSLHILVQQGKVLYLGVCNTPAWIVSAANTYAKAHGKTQFSVYSGRWSLLVRDMEREIVPMARAFGMAIVPWGVLGQGKFQSDEAIKEREESGEPLRPYGGGREVELSRALTTVAAEQGTNSVTAIALAYILRKAALLGVHNVFPVVGGRKTEQLKDNIAALSIWLTEAQVAYLESVKDFDIGYPSSMIGEDPNVTGIPGHMSATSAYLAFPGATKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GYZ6</accession>
    <name>A0AAJ0GYZ6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Superoxide dismutase</fullName>
            <ecNumber evidence="13">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0T15DRAFT_392023</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="function">
        <text evidence="2">Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="13"/>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724130.1">
        <property type="nucleotide sequence ID" value="XM_062864613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GYZ6"/>
    <dbReference type="GeneID" id="87883442"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.990:FF:000001">
        <property type="entry name" value="Superoxide dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.55.40.20:FF:000004">
        <property type="entry name" value="Superoxide dismutase [Fe]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050265">
        <property type="entry name" value="Fe/Mn_Superoxide_Dismutase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404:SF29">
        <property type="entry name" value="SUPEROXIDE DISMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404">
        <property type="entry name" value="SUPEROXIDE DISMUTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase N-terminal" evidence="14">
        <location>
            <begin position="36"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="15">
        <location>
            <begin position="130"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3308350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="241" mass="26456" checksum="0DAAF5D641609538" modified="2024-07-24" version="1">MVNISNLWHYLALQSPLHSTTLSGDSFNITTMGLTTYTLPALPYAYDALEPHISAQIMELHHSKHHQAYVTNLNKALESHAAALAANDVAAQIALQQAIKFNGGGHINHSLFWKNLAPTGSEETRPDAAKELVAAIEKTWGSFDSFKKAFSATLLSLQGSGWGWLVKEAGNGGGLRIVTTKDQDPVVGGDVPIFGVDMWEHAYYLQYLNGKAAYVENIWNVINWETAEARFSGRSDEKTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GZ00</accession>
    <name>A0AAJ0GZ00_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_117633</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724532.1">
        <property type="nucleotide sequence ID" value="XM_062861580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GZ00"/>
    <dbReference type="GeneID" id="87880409"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3308752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="140" mass="15707" checksum="4095E9ECDA4BA8F3" modified="2024-07-24" version="1">MEISKPTSKYTKTLFELGTVGYVILIESPSQQTQLSHDTVLAAAKILRDNSKLTLEVIQEVVQRDLIPGCSPRELDFLMRIAVQAMFMIDPNVKDAHGRDFTIRTYRHVSQLAQGGHCRLRDKMFPSGLSRESEPSCLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GZ50</accession>
    <name>A0AAJ0GZ50_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">guanosine-diphosphatase</fullName>
            <ecNumber evidence="5">3.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_430054</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">After transfer of sugars to endogenous macromolecular acceptors, the enzyme converts nucleoside diphosphates to nucleoside monophosphates which in turn exit the Golgi lumen in a coupled antiporter reaction, allowing entry of additional nucleotide sugar from the cytosol.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.42" evidence="5"/>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724626.1">
        <property type="nucleotide sequence ID" value="XM_062865715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GZ50"/>
    <dbReference type="GeneID" id="87884544"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004382">
        <property type="term" value="F:GDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045134">
        <property type="term" value="F:UDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009134">
        <property type="term" value="P:nucleoside diphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24040">
        <property type="entry name" value="ASKHA_NBD_GDA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782">
        <property type="entry name" value="ADENOSINE/GUANOSINE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782:SF83">
        <property type="entry name" value="GUANOSINE-DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01238">
        <property type="entry name" value="GDA1_CD39_NTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="81"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="277"/>
            <end position="281"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3308846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="554" mass="60777" checksum="0420CA6AB3E038BD" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GZM9</accession>
    <name>A0AAJ0GZM9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 17">Delta-aminolevulinic acid dehydratase</fullName>
            <ecNumber evidence="5 17">4.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B0T15DRAFT_127726</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 17">
            <text>2 5-aminolevulinate = porphobilinogen + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="4.2.1.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 17">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the ALAD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.24" evidence="5 17"/>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3309042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724822.1">
        <property type="nucleotide sequence ID" value="XM_062861708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GZM9"/>
    <dbReference type="GeneID" id="87880537"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004655">
        <property type="term" value="F:porphobilinogen synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04824">
        <property type="entry name" value="eu_ALAD_PBGS_cysteine_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000048">
        <property type="entry name" value="Delta-aminolevulinic acid dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001731">
        <property type="entry name" value="ALAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030656">
        <property type="entry name" value="ALAD_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006762">
        <property type="entry name" value="PRK09283.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458">
        <property type="entry name" value="DELTA-AMINOLEVULINIC ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458:SF0">
        <property type="entry name" value="DELTA-AMINOLEVULINIC ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00490">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001415">
        <property type="entry name" value="Porphbilin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00144">
        <property type="entry name" value="DALDHYDRTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01004">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00169">
        <property type="entry name" value="D_ALA_DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="10 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 17" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="14">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="14">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="371"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAK3309042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="382" mass="41638" checksum="34A6D8847764EC95" modified="2024-07-24" version="1">MSFSSLVQDLSLRDSSAPRRRADASVSTIDDRASHLSLAKSYTSTAATSVSISGDIASQLHAGYCHPLARSWQAERQLTKSMLIYPLFISDQDDEEVLIPSLPNQYRRGINRLVPFLEPLVHKGLRSVILFGVPMRPGTKDALGTAADDPEGPVIRSIRLLRQRFPHLYIVVDVCLCEYTSHGHCGILRDDGSLNNQLSVDRISDVAVAYARAGAHCVAPSDMNDGRIRAIKLKLIEEGIVHSVTLMSYAAKFSGCLYGPFRDAAGSAPSFGDRRCYQLPPGGRGLARRAIVRDIAEGADIIMVKPAGQYLDIISDAKELGRDLPIAAYQVSGEFAMIHAAAKAGVFDLKTMAFESTEGILRAGATIIISYFVPEFLDWLDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GZR5</accession>
    <name>A0AAJ0GZR5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dual-specificity kinase</fullName>
            <ecNumber evidence="2">2.7.12.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0T15DRAFT_483563</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.1" evidence="2"/>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3309129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724909.1">
        <property type="nucleotide sequence ID" value="XM_062866170.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87884999"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14210">
        <property type="entry name" value="PKc_DYRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000112">
        <property type="entry name" value="Putative dual specificity tyrosine-phosphorylation-regulated kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.10.30">
        <property type="entry name" value="DYRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042521">
        <property type="entry name" value="DYRK"/>
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    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF22">
        <property type="entry name" value="DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="934"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="113"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="287"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="432"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="495"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1226"/>
            <end position="1382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="113"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="215"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="233"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="308"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="328"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="344"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="360"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="433"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="455"/>
            <end position="466"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="511"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="545"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="577"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="645"/>
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    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="658"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
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        <location>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="771"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="12">
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    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="12">
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    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1323"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1370"/>
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    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="963"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049003"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3309129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1382" mass="149455" checksum="89023B06B606F557" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GZS3</accession>
    <name>A0AAJ0GZS3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bactericidal permeability-increasing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_412218</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3309191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_062865403.1"/>
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    <dbReference type="AlphaFoldDB" id="A0AAJ0GZS3"/>
    <dbReference type="GeneID" id="87884232"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017943">
        <property type="entry name" value="Bactericidal_perm-incr_a/b_dom"/>
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    <dbReference type="InterPro" id="IPR027842">
        <property type="entry name" value="HAM1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045967">
        <property type="entry name" value="HAM1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31138">
        <property type="entry name" value="CHROMOSOME 19, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31138:SF4">
        <property type="entry name" value="DUF5923 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14613">
        <property type="entry name" value="HAM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19343">
        <property type="entry name" value="HAM1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55394">
        <property type="entry name" value="Bactericidal permeability-increasing protein, BPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="209"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="HAM1-like C-terminal" evidence="2">
        <location>
            <begin position="595"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3309191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="743" mass="84704" checksum="CDA3A660A5856729" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GZT0</accession>
    <name>A0AAJ0GZT0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_118155</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724550.1">
        <property type="nucleotide sequence ID" value="XM_062861585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GZT0"/>
    <dbReference type="GeneID" id="87880414"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017102">
        <property type="term" value="C:methionyl glutamyl tRNA synthetase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050132">
        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF5">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="7">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3308770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="149" mass="16430" checksum="773622DDC91DA341" modified="2024-07-24" version="1">MASSKVMDWAPSLSAPDFKAVEAVLLELERYLTLRTYLQGYQLSTADKDIWTALRTNKVANGIVRKGSLTNVARWSSFIEASHPEIQGEIKAAQTKEKEKRAAASRAGGNYNIGLKNTENGIVTRFPPEPSGYLHIGHAKAAFLNDYFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H092</accession>
    <name>A0AAJ0H092_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_545205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725223.1">
        <property type="nucleotide sequence ID" value="XM_062870124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H092"/>
    <dbReference type="GeneID" id="87888953"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="300"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3309443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="358" mass="41070" checksum="690849A1D9AEF27D" modified="2024-07-24" version="1">MASQMTSDSLDRVTAPSSSEDERPVEPVWLDVSTVKEILQHIVDSRRSGSESTFAFHWQPTQVYDLSDQLDAGLAELGQPKVRRFEYDFKSGTVYLDVMSESVLHFMVQIGLHDHFKYIIARLLATADEPIIRDSLQSVVDRGTASLNIDDKILTQPDAETRPHVEEKARKYIDLSDNKIQVVLILDLQRPGIKKAWVSLLVVDDSSSHWIRQHELFHDDNLDQQPVGHIDLYLSDFVGIAGLPAIYCRPSTAELTAGITRNPIATLTYEQLRAIFRRARHCHNPTEFTTEVGDKEENPYEEAERRVVEVRNKERLESERRLAEEWIKADRRLAEVEWQVADLKRRVAGFEQQCRGPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H0A6</accession>
    <name>A0AAJ0H0A6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_488193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725243.1">
        <property type="nucleotide sequence ID" value="XM_062866481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H0A6"/>
    <dbReference type="GeneID" id="87885310"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042484793" evidence="1">
        <location>
            <begin position="20"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3309463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="92" mass="10304" checksum="C936084A61BF7FCB" modified="2024-07-24" version="1">MKLTVSLSFLTLILGLALAQQDFPECTQDLLRTDECAAVVNPTACYNQFRWSARTLGCIDGTDDADRKRKACKCCSCVGTVMCNWVRQNRFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H0D2</accession>
    <name>A0AAJ0H0D2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">MICOS complex subunit MIC60</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Mitofilin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0T15DRAFT_515636</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a role in keeping cristae membranes connected to the inner boundary membrane. Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 13">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion inner membrane</location>
            <topology evidence="1 13">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the MICOS complex subunit Mic60 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725269.1">
        <property type="nucleotide sequence ID" value="XM_062868207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H0D2"/>
    <dbReference type="GeneID" id="87887036"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019133">
        <property type="entry name" value="MIC60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15415:SF7">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15415">
        <property type="entry name" value="MITOFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09731">
        <property type="entry name" value="Mitofilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="45"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="171"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="400"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="267"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3309489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="670" mass="73631" checksum="09395A54E8D57DF8" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H132</accession>
    <name>A0AAJ0H132_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribonuclease H1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_570549</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725644.1">
        <property type="nucleotide sequence ID" value="XM_062870840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H132"/>
    <dbReference type="GeneID" id="87889669"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.970.10">
        <property type="entry name" value="Ribonuclease H1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_bL9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011320">
        <property type="entry name" value="RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037056">
        <property type="entry name" value="RNase_H1_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01693">
        <property type="entry name" value="Cauli_VI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="L9 N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribonuclease H1 N-terminal" evidence="2">
        <location>
            <begin position="29"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="Ribonuclease H1 N-terminal" evidence="2">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3309864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="202" mass="22525" checksum="82D3573BC9BE6332" modified="2024-07-24" version="1">MSSASRKVVSATTAEPPSKKRKMDASEQKYYAVRARFKPGVYTSWAQCQQQIAGFKGAQYAAAFAAGRSPSSATSDNKPPRFYGVAVGRKPGVHTEWSAAQEAIICTDTGEYRVRYVGFGALGLGCLHFASPRPTQLKMTKQAPENYFDVEDILSVKVKYWHFDPRLQQQFHEEKGSVEAWIAREIRDLETAPEGRPPFNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H181</accession>
    <name>A0AAJ0H181_9PEZI</name>
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        <submittedName>
            <fullName evidence="6">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="6" type="ORF">B0T15DRAFT_516962</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062868292.1"/>
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    <dbReference type="GeneID" id="87887121"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19846:SF0">
        <property type="entry name" value="PRE-MRNA PROCESSING FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19846">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
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        <property type="match status" value="6"/>
    </dbReference>
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        <property type="entry name" value="GPROTEINBRPT"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158230">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
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        </location>
    </feature>
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        <location>
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        </location>
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        </location>
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    </evidence>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="5">Transmembrane protein</fullName>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
    <dbReference type="RefSeq" id="XP_062725747.1">
        <property type="nucleotide sequence ID" value="XM_062866531.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87885360"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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        <location>
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        </location>
    </feature>
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        <location>
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            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3309967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="26188" checksum="7703447637181C99" modified="2024-07-24" version="1">MSNNDNDSSPKPAVSNPPTASPPSTHNHSSPGHIQPQPPPPLPPPPQQVKEGGEEPPHLTSSMSRPNPNKWWPALSFSFSFAPTTTDNVIELLWDVALAFFAVRLALLYAALVAGSSILLLLLLPLHFPAPLPLPVPVTVVLACSAFWARVVVKWCEVPPVAGFRLAVGGAAVVLVLLAEGVGGFVWCEVLRRQGVGMMMMGGWMSLLGALAGFGLMPALLMMVGGGGKGEKGRANAAAAAAGLGEGSWEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H1B4</accession>
    <name>A0AAJ0H1B4_9PEZI</name>
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        <recommendedName>
            <fullName evidence="4">Protein DSF2</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">B0T15DRAFT_20051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
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    <reference evidence="2" key="1">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
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                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAK3309984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062862565.1"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:negative regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Sel1-like"/>
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        <property type="entry name" value="TPR-like_helical_dom_sf"/>
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        <property type="entry name" value="PROTEIN DSF2"/>
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        <property type="match status" value="3"/>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H1D3</accession>
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    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
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                <person name="Barry K."/>
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                <person name="Grigoriev I.V."/>
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        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <person name="Labutti K."/>
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                <person name="Ament-Velasquez S.L."/>
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                <person name="Barry K."/>
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                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
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    </reference>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="entry name" value="MFS_dom"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF48">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G02700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <begin position="131"/>
            <end position="153"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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    </feature>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3309750.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H1F7</accession>
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        <recommendedName>
            <fullName evidence="9">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Chaetomium strumarium</name>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
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                <person name="Kruys A."/>
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                <person name="Powell A.J."/>
                <person name="Barry K."/>
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                <person name="Grigoriev I.V."/>
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                <person name="Hiltunen Thoren M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
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                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
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                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        </source>
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        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
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                <person name="Riley R."/>
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                <person name="Chen C."/>
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                <person name="Ng V."/>
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    </reference>
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        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
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                <person name="Ng V."/>
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                <person name="Steindorff A."/>
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                <person name="Martin F."/>
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                <person name="Natvig D."/>
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                <person name="Powell A.J."/>
                <person name="Barry K."/>
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                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Ng V."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
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                <person name="Ng V."/>
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                <person name="Steindorff A."/>
                <person name="Ohm R."/>
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                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER. Is required for secretory polypeptide translocation. May physically associate with SEC63 protein in the endoplasmic reticulum and this interaction may be regulated by ATP hydrolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.10" evidence="3"/>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725990.1">
        <property type="nucleotide sequence ID" value="XM_062868328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H2A8"/>
    <dbReference type="GeneID" id="87887157"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10241">
        <property type="entry name" value="ASKHA_NBD_HSP70_BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000005">
        <property type="entry name" value="Heat shock protein ssb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042050">
        <property type="entry name" value="BIP_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0346">Stress response</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042604518" description="Endoplasmic reticulum chaperone BiP" evidence="14">
        <location>
            <begin position="37"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="594"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3310210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="614" mass="67067" checksum="A25FF14F1817982D" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H2D1</accession>
    <name>A0AAJ0H2D1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein uL10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">60S acidic ribosomal protein P0</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_385551</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726351.1">
        <property type="nucleotide sequence ID" value="XM_062864285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H2D1"/>
    <dbReference type="GeneID" id="87883114"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05795">
        <property type="entry name" value="Ribosomal_P0_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1730:FF:000002">
        <property type="entry name" value="60S acidic ribosomal protein P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.105.20:FF:000001">
        <property type="entry name" value="60S acidic ribosomal protein P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050323">
        <property type="entry name" value="Ribosomal_protein_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030670">
        <property type="entry name" value="uL10_eukaryotes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039087">
        <property type="entry name" value="L10E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL10-like insertion" evidence="8">
        <location>
            <begin position="109"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="277"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="277"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="294"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3310571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="330" mass="35328" checksum="79B6A34513EF36F6" modified="2024-07-24" version="1">MGGKSGNKAGYFDKLKGLLEEYRSIFIVSVDNVSSQQMHEIRQALRGEGVVLMGKNTMVRRALKTFVADTPEYERLLPFVKGNVGFVFTNGDLKDIRDKILSNRVAAPARAGAIAPVDVWVPAGNTGMEPGKTSFFQALGVPTKIARGTIEITTDLKLVEAGGKVGPSEATLLNMLNISPFTYGMGIAQVYDQGNTFPASVLDIGEEQLLKSFSSAVTTIAAISLALNFPTLPSVIHSLVNSYKKVLAVAIETDISWPEIEQLKDRIANPEAYAAAAPAAAAASGPAETKAEEKEEEKEEESDEDGGFGDLLFVPPRLTSSRTMLTIDSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H2H5</accession>
    <name>A0AAJ0H2H5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RED-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_518878</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726361.1">
        <property type="nucleotide sequence ID" value="XM_062868394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H2H5"/>
    <dbReference type="GeneID" id="87887223"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039896">
        <property type="entry name" value="Red-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012916">
        <property type="entry name" value="RED_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12765">
        <property type="entry name" value="RED PROTEIN IK FACTOR CYTOKINE IK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07808">
        <property type="entry name" value="RED_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RED-like N-terminal" evidence="4">
        <location>
            <begin position="75"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="74"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="164"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="241"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="328"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="426"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="255"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="432"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="502"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3310581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="533" mass="59291" checksum="A31C1875EE2888A9" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H2S4</accession>
    <name>A0AAJ0H2S4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">D-arabinitol dehydrogenase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_498858</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726563.1">
        <property type="nucleotide sequence ID" value="XM_062867325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H2S4"/>
    <dbReference type="GeneID" id="87886154"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050085">
        <property type="term" value="F:mannitol 2-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019594">
        <property type="term" value="P:mannitol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000090">
        <property type="entry name" value="NADP-dependent mannitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF14">
        <property type="entry name" value="DEHYDROGENASE ARBD, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="46"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3310783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="400" mass="42404" checksum="6AC98F15FD462535" modified="2024-07-24" version="1">MSLQLGRVLRTAAGRRGPASRILGNAPGSVSTAIVTAPARLRASAGFHTVPAVRRQDQNRTTGTKSTSNNNNNNNKTEKKEKKKKPTDEEIAAVAGSYARTDDSITVEYPPDEQLPSSKPVAGAGRAGAHVFPTLASFSLQGKVGVVTGGARGLGLVMGQGMVISGADLAIVDLNKEEAVRQAENIVETFKRDHPDAKKIPKVTAHYADVSDPASVDACIAEIVAAHGKIDNLVTSAGFTENFEAINYPIDRMRKLWGVNVDGTYLFATAVARHLMARNAKGSMVFIGSMSGAIVNVPQPQAPYNAAKAAVRHLCASLSVEWAKAGIRVNCISPGYMLTALTQKILDDKPDLKRQWTSLIPQGHMGSPEDLMGPVTFLLSDASSYVTGADLRVDGGYTVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H2X7</accession>
    <name>A0AAJ0H2X7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_507388</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726532.1">
        <property type="nucleotide sequence ID" value="XM_062867644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H2X7"/>
    <dbReference type="GeneID" id="87886473"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000088">
        <property type="entry name" value="Ras-related C3 botulinum toxin substrate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0636">Prenylation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3310752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="202" mass="22179" checksum="B1A4C85E2721BC1D" modified="2024-07-24" version="1">MAAQGNVQSIKCVVTGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSASVTVDGKPISLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLISPPSFDNVKAKWYPEIDHHAPNIPIILVGTKLDKRDDRETCDKLAEQRMAPISFAKGVACAQEIGAYKYVECSALTQVNLKAVFDNAIRAVLEPKKQTKQANKPKSKCTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H306</accession>
    <name>A0AAJ0H306_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nucleolar protein 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_426116</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726355.1">
        <property type="nucleotide sequence ID" value="XM_062865643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H306"/>
    <dbReference type="GeneID" id="87884472"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030692">
        <property type="term" value="C:Noc4p-Nop14p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007276">
        <property type="entry name" value="Nop14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23183">
        <property type="entry name" value="NOP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23183:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04147">
        <property type="entry name" value="Nop14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="139"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="315"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="425"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="900"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="839"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="216"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="315"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="356"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="909"/>
            <end position="919"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3310575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="919" mass="104988" checksum="E02CBCC7082E10CE" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H369</accession>
    <name>A0AAJ0H369_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_46639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726489.1">
        <property type="nucleotide sequence ID" value="XM_062865976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H369"/>
    <dbReference type="GeneID" id="87884805"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3310709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="414" mass="47621" checksum="C481CB5DB3DB9EE2" modified="2024-07-24" version="1">MAPFMTVERAHRSYGPVDKEALAGRLSKSERGMLRMGLVKSEQWRQLPTEGLYQVVISEVLDDGATYPLERGGGRAFAVTCVLDLGLRMLESARGRSALESLAGKAIRVWRERPLGPIREPASVDVPAAVDEFLRCVRHRFPAVKLDDRNGFCHEEENKKMPYSWVDELSTLEQSKFNPKAAAVLHLNWQLMEKLYWTRLKADVARRQRRDDEHQAETVRFHRLQFHLGAMVTHHLCHLFVNFLRQFEDLAYEVTDADFMRLVRRYDPGAEFEIDFFGGRPKLFVDYRGPRQESYAGQSYVIKRGRNGMRMAAAVAQYKIESYLRGDFSVPLLTEVEGDVFPMERYQDVKRRHGSSGQESQWREGQTGSRRVAEVGSADQQPLSVPWDIKGVEYQLVKRACFDPAIRIVDFKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H3C4</accession>
    <name>A0AAJ0H3C4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SPT8-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_59985</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726826.1">
        <property type="nucleotide sequence ID" value="XM_062871113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H3C4"/>
    <dbReference type="GeneID" id="87889942"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057544">
        <property type="entry name" value="Beta-prop_SPT8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23798">
        <property type="entry name" value="Beta-prop_SPT8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Transcription factor spt8 beta-propeller" evidence="5">
        <location>
            <begin position="113"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="243"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor spt8 beta-propeller" evidence="5">
        <location>
            <begin position="539"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="318"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="479"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="383"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="434"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="479"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="500"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="511"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3311046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="711" mass="75033" checksum="4A1EE83A9B89137D" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H3G6</accession>
    <name>A0AAJ0H3G6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0T15DRAFT_62083</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726903.1">
        <property type="nucleotide sequence ID" value="XM_062871134.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87889963"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05611">
        <property type="entry name" value="STKc_Rim15_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000340">
        <property type="entry name" value="Serine threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000664">
        <property type="entry name" value="Serine threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000377">
        <property type="entry name" value="Serine threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000139">
        <property type="entry name" value="Serine threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE GREATWALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="14">
        <location>
            <begin position="36"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="716"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="15">
        <location>
            <begin position="1145"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="13">
        <location>
            <begin position="1516"/>
            <end position="1630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="293"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="461"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="505"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="889"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="970"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1184"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1278"/>
            <end position="1453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1657"/>
            <end position="1680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1750"/>
            <end position="1854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1909"/>
            <end position="1986"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="26"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="565"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="891"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="912"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="970"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="999"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="1014"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1281"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1308"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1361"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1392"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1415"/>
            <end position="1428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1429"/>
            <end position="1449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1770"/>
            <end position="1788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="1811"/>
            <end position="1828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1829"/>
            <end position="1839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1840"/>
            <end position="1849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3311123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1986" mass="214677" checksum="F329CE1395360640" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H3I6</accession>
    <name>A0AAJ0H3I6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">cAMP-dependent protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0T15DRAFT_51757</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.11" evidence="1"/>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726620.1">
        <property type="nucleotide sequence ID" value="XM_062868315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H3I6"/>
    <dbReference type="GeneID" id="87887144"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd05580">
        <property type="entry name" value="STKc_PKA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF37">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="61"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="333"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3310840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="390" mass="44051" checksum="DDCE9A158E3127A4" modified="2024-07-24" version="1">MAATVAQSQGISPGLHPLQAAALRAASSAEQGQGQGQQQQQRGFDDEPFDICSGKLSVGDFVRVRTLGTGTFARVCLVRPSHGSDAERCKVYALKILRKTEVIKLKQLDHVRHERQILADVKGHPFITNFLASFSDRNFLYILLDYVPGGELFSYLRKLRRFDEDTARFYAAEIVLILEHLHEHQGGIAYRDMKPENLLLDADGHIKLVDFGFAKRLGNNESGHPVETYTLCGTPEYLAPEVIHNKGHTTAVDWWALGILIYEFLTGYPPFWHQNPLEIYKQIVGRPVVFPQEPVISDAAKDIIRQFCTVDRSHRLGNISGGAAKVKEHPFFAGVDWDAIYQKRHKGPIVPPVRYPGDAQCFDVYPEEDVAKDEYTDEMAERYDDYFADF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H4H7</accession>
    <name>A0AAJ0H4H7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_386360</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727444.1">
        <property type="nucleotide sequence ID" value="XM_062864319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H4H7"/>
    <dbReference type="GeneID" id="87883148"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003838">
        <property type="term" value="F:sterol 24-C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050447">
        <property type="entry name" value="Erg6_SMT_methyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068:SF1">
        <property type="entry name" value="HYPOTHETICAL LOC100005854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068">
        <property type="entry name" value="ZGC:194242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="3">
        <location>
            <begin position="79"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3311664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="303" mass="34614" checksum="7AB38D53D8878A64" modified="2024-07-24" version="1">MAAHRRDSTEPLIEPNPHLKSYYESLESRIGYRLVLGGTRHFGYYEKDTYWPFPVGKALRAMEDKMFRALDLPVGSQVLDAGCGVAHVALYMARRGLRITGVDIIDHHIAKAKRNVARAGLPPGQISIQKMDYHHLDAIPDQSHDGVYTMETFVHATDPEQVLADFYRILKPGGRLVLFEYDHEIDADERVPQHVVEDMNLVNQYAAMPTNARSHKGVFASMLEHTGFSDIKEEDYSKNIRPMLRLFWVMAAIPYFIIKLLRLERWFINTVAGAQGYLHQEHWRYVAITATKPGPKIEAAKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H4T4</accession>
    <name>A0AAJ0H4T4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_389203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727285.1">
        <property type="nucleotide sequence ID" value="XM_062864475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H4T4"/>
    <dbReference type="GeneID" id="87883304"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="256"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3311505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="509" mass="53461" checksum="B6F0BE1C83983F71" modified="2024-07-24" version="1">MGSQQTTPKLQSRDASPSPRVDTTESASSLPTSADTEHPEVTPIAPLNPRRATPEVSTMSQPVLSLPPFETGSTLQASTDSPVKDSDMLSAEIIKSLSPGQEVASGTDVVEGSTATYNAPVADPTRESSYLGDVYGDYWATTEDKAEPSVLTSARADEPGKAAQNHPPPSPNAPADNQAVVESKRGSTSSSIPSINTLAKSPEVQAETATESGGLRRRFSWEAALEGSVPVGLSSPGAALFTEQKALGSGAETVSTPTTKPTAPETEPSRPAQYAEGMKSADDLRAESAPELLGPAPSTDRRRESPSPLSVLSDERKESKRLSLAEEKIVLQPDLPSPPLEQHPVFATVQESRRAEPATPPSPQNLLGFRTIMEMSLASERIKHYKETRWQFSAVDTGLDDWLKAMLSRHPEHANAVMSYASAAASQAQHGSQGAAPASGQGARAPAHLPMAHLQHSLGGLGHSSNQMGAKSKELLMAAGKAGKGFGKGLLSKGRSKLRGTGDKVFSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LY65</accession>
    <name>A0AAJ0LY65_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="8">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_403648</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="8"/>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717794.1">
        <property type="nucleotide sequence ID" value="XM_062865219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LY65"/>
    <dbReference type="GeneID" id="87884048"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000164">
        <property type="term" value="C:protein phosphatase type 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07414">
        <property type="entry name" value="MPP_PP1_PPKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000004">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF300">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="10">
        <location>
            <begin position="121"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="314"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3302014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="324" mass="37174" checksum="AF61FA4FB0233BA1" modified="2024-07-24" version="1">MADQHEVDLDSIIDRLLEVRGSRPGKQVQLLEAEIRYLCTKAREIFISQPILLELEAPIKICGDIHGQYYDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFILRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIIDEKIFTMHGGLSPDLNSMEQIRRVMRPTDIPDCGLLCDLLWSDPDKDITGWSENDRGVSFTFGPDVVSRFLQKHDMDLICRAHQVVEDGYEFFSKRQLVTLFSAPNYCGEFDNAGAMMSVDESLLCSFQILKPAEKKQKYVHGLGGGSRPTTPRKQSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LYT6</accession>
    <name>A0AAJ0LYT6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_487737</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718512.1">
        <property type="nucleotide sequence ID" value="XM_062866458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LYT6"/>
    <dbReference type="GeneID" id="87885287"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF155">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="37"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="325"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="435"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="355"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="440"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3302732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="459" mass="48891" checksum="140A15D474C96666" modified="2024-07-24" version="1">MSSAAPLPAHLAAEDKGPGIIATICVVTVLETLFCAARIYTRGRILGRLHLDDYLVMLSVSQVMGWASVTFSIMAVRSGNGKHFDILTTEQKSGAILWTMVGFCPGILSFGIPKLAVIALLSRLMNPSRKHRIFLWTLGIVCVLSLLGCVVVLFGRCTPSRSLWDFDVAPESCFDVWILVNYAIYAGTFSAFTDLYLAVYPAIVLFSLRMNMRKKLALSGALGVGSIATIVAIYKTTRLPGLASPDFSYDTSDLVVWTAVEGATIIIASCIPVLQPFVDKVVSSRIFGSFSGTRGGRGGYHQNNSSGPNSKGDYYYHGRSGGHVTTSGGGGGIELSRSSHKRSAVKDPNSLTFLDETRAGSEESILKNNGQPEPLAAVPEYESNNNSNNNRSERAATFGGGEGSSSIELQAPSPTATVGANAGIVRTTVVSVSYGGQEASEDHNTGRTRWEARGPGSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZH0</accession>
    <name>A0AAJ0LZH0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_540225</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719217.1">
        <property type="nucleotide sequence ID" value="XM_062869777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZH0"/>
    <dbReference type="GeneID" id="87888606"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049680">
        <property type="entry name" value="FLVCR1-2_SLC49-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924:SF6">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 49 MEMBER A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="296"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3303437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="382" mass="40204" checksum="7FDD60135A2A06B4" modified="2024-07-24" version="1">MTPMVIYVLHLGPKLSIVTAAALILVGNWIRFAGSHSGSGGLFGVVMFGQILTGLAQPFVLAAPSRYSDLWFSNRGRVAATALTSLANPFGAALGQLIVPFWVGQPSDISRMVLYVSIISSVCAVPSFFIPARPPTPVAPSSETAKLSLRASTAILFNHVEFWLLFIPFAIYVGLFNSTSSLLNQILLPYGYDDVEAGIAGAILIVVGLVASAVTSPLIDRTKSYLLAIRVAVPLIGLCYLVFVWMPATRNDDDGGGVAGPYVVLAVLGAASFSLLPVVVEYLVELTHPISPEVTSTLAWSGGQLLGGVFIVVSGALKADPGEGDPPANMHDALIFAAVMALAAVPLPLCLGLFGRKENLQLRRVRSDEEGRVSGDSAEDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZU4</accession>
    <name>A0AAJ0LZU4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_283860</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719561.1">
        <property type="nucleotide sequence ID" value="XM_062863613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZU4"/>
    <dbReference type="GeneID" id="87882442"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000140">
        <property type="term" value="F:acylglycerone-phosphate reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169:SF6">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="5">
        <location>
            <begin position="6"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3303781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="284" mass="29834" checksum="4ED105BC0F18DB42" modified="2024-07-24" version="1">MATPKKTVLITGCSAGGIGAALAHELAKQGHHVYATARNTAKIPAELSGLPNVTTFALDVASDASVREAAKTVAESGKALDVLINNAGYGYTMPLLDVDIAHAQQLHDTNLWGVLRCVQAFSDLLIASKGRIVNISSVGAVVNTPWIGTYASSKAALNSLSDTLRLELSPFGVTVVTIMVGTVATPFHANEPEVVLPPKSRYAAIRDTINRWAKGEAGPKGGPVEELARSVVPDIVGKEKRAQVWKGANAGAVKFVSRWVPSSMLDGMMSNGQGLDKLAKSLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZU6</accession>
    <name>A0AAJ0LZU6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoribosylaminoimidazole-succinocarboxamide synthase</fullName>
            <ecNumber evidence="3">6.3.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">SAICAR synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_487094</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAICAR synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.6" evidence="3"/>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719550.1">
        <property type="nucleotide sequence ID" value="XM_062866410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZU6"/>
    <dbReference type="GeneID" id="87885239"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004639">
        <property type="term" value="F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01414">
        <property type="entry name" value="SAICAR_synt_Sc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000015">
        <property type="entry name" value="Phosphoribosylaminoimidazole-succinocarboxamide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00137">
        <property type="entry name" value="SAICAR_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028923">
        <property type="entry name" value="SAICAR_synt/ADE2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001636">
        <property type="entry name" value="SAICAR_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018236">
        <property type="entry name" value="SAICAR_synthetase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010568">
        <property type="entry name" value="PRK13961.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00081">
        <property type="entry name" value="purC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43700">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43700:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01259">
        <property type="entry name" value="SAICAR_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01057">
        <property type="entry name" value="SAICAR_SYNTHETASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01058">
        <property type="entry name" value="SAICAR_SYNTHETASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAICAR synthetase/ADE2 N-terminal" evidence="10">
        <location>
            <begin position="17"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3303770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="315" mass="35382" checksum="8AE735E085535B5B" modified="2024-07-24" version="1">MAAEVLTDMQLTSLPKISQGKVRDLFSLPDGDKPTLLFVTSDRISAYDVILKNGIPTKGVILTLLSAKWFEILSSRVPGLKHHFLHLGPPTSPGLITEDEKNMLRGRSMTVRRLKIFPIEAIVRGYVTGSAWAEYEKTQTIHGLPQPAGLRRCERLPEPIYTPSTKAELGDKDINISPEEARKLVGDKYASRIEELALACYKAGAAYAEERGIIIADTKFEFGLDDVTDEIYLVDEVLTPDSSRFWSRADYQVGREQDSFDKQVLRNWLTDHGLKGKPDVEMPPEVVEKTKARYTEVFERLIGNSFEDALKNLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZY6</accession>
    <name>A0AAJ0LZY6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LTD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_485707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3303917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719697.1">
        <property type="nucleotide sequence ID" value="XM_062866305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZY6"/>
    <dbReference type="GeneID" id="87885134"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1260">
        <property type="entry name" value="Lamin Tail domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019268">
        <property type="entry name" value="DUF2278"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001322">
        <property type="entry name" value="Lamin_tail_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036415">
        <property type="entry name" value="Lamin_tail_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10042">
        <property type="entry name" value="DUF2278"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00932">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74853">
        <property type="entry name" value="Lamin A/C globular tail domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51841">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LTD" evidence="1">
        <location>
            <begin position="219"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3303917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="351" mass="39012" checksum="6F06BEC422C8B077" modified="2024-07-24" version="1">MIILCSLYPIRPIRYTYEDRDQDSVSPHLSLYFADNEDGEGRAAINIKSGDRRESRLAYWTVPRFAHPITQKLAALDNGFRRLAGTSEQGPGTLAIDFIRSNLFRRSDGRILPHDVDGPNNDILDQLKPILDRAILAGATVYIYGTQFSNGKGIHNVHMNQGNPQRWGWENGVFQDGALILDFEDHWEAIFIGFASQAVHTEDGPNEAGQPLPRTGYMTWANFLAPKSAFDDRSRAKYDLDDSPVFITRALVNPLRRDNQPGTPPQTVTLANRKDKEQDLSGWKIRNEATEDQELPAPQKIAAKGTVIVKVPDAPLNNQGGTITLLNAQGFKVHGVSYTKAQAQDGTVSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M041</accession>
    <name>A0AAJ0M041_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">T-complex protein 11-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_228284</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TCP11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719834.1">
        <property type="nucleotide sequence ID" value="XM_062862910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M041"/>
    <dbReference type="GeneID" id="87881739"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010737">
        <property type="term" value="P:protein kinase A signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008862">
        <property type="entry name" value="Tcp11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12832:SF11">
        <property type="entry name" value="LD23868P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12832">
        <property type="entry name" value="TESTIS-SPECIFIC PROTEIN PBS13 T-COMPLEX 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05794">
        <property type="entry name" value="Tcp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="60"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="103"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3304054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="692" mass="77036" checksum="B8562F6AC40A83BD" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M048</accession>
    <name>A0AAJ0M048_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription factor CBF/NF-Y/archaeal histone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_535470</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the CENP-W/WIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719865.1">
        <property type="nucleotide sequence ID" value="XM_062869498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M048"/>
    <dbReference type="GeneID" id="87888327"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13732">
        <property type="entry name" value="HFD_CENP-W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000075">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052484">
        <property type="entry name" value="CENP-W/WIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34832">
        <property type="entry name" value="CENTROMERE PROTEIN W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34832:SF1">
        <property type="entry name" value="CENTROMERE PROTEIN W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="8">
        <location>
            <begin position="8"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3304085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="77" mass="8583" checksum="0790E0564059AF63" modified="2024-07-24" version="1">MAGQKLYPRATVKKIVKAHSNCNVSKNADVMMFLDYMLFMQTLMREATIEAKQGGERGITARSVKKVTADSLAKFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M052</accession>
    <name>A0AAJ0M052_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_512298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719880.1">
        <property type="nucleotide sequence ID" value="XM_062867972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M052"/>
    <dbReference type="GeneID" id="87886801"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3304100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="504" mass="55217" checksum="062304886615AEAD" modified="2024-07-24" version="1">MGRLASKLVRGASLPELIVANLASLRSFLQRSARRPPYPEEEGIELPELSSTGVALPHPAPAKLSIRRFPVANTPSSRRFRRRLSRHAPSVEEEGIELSELSELASIGVALPPRPSPSSPPDPACGFRPSTSTFTGPPRVHKPPPEPPPEPSPVNIFGISDDPGNWADLEVETEDDPEPPRSKIGNFLSALGNRLRKRPGHPRIAHHLRKLQGIATTRHPYPNNHKLFNFDTKPLLCRLFHPPDANREYRAELRRRLYDQMADALCLELCGIGPWAPVSCGDFFQWVAPRGPHGRPLGRWAHETAYLPRGSCESALRGDDPLDTAAFPDQTASPFFPVYARPLSSSQPGPACGGSINGTAAGSALLTPSCPSETATIRRTATGSVLLAPSRPDDTSAKRRTAAGRDFARNPPEAHVPPIHTSVVGRKHLSGKEGTRHQWSRPFRHPASSKAWVRRKRPSRRSRSNQLLVGLPSALPSIPEEGLADMLMQQIYDLQDQMLSDTNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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        <name evidence="2" type="ORF">B0T15DRAFT_575674</name>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719951.1">
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    <dbReference type="GeneID" id="87889828"/>
    <dbReference type="Proteomes" id="UP001273166">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3304171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="189" mass="21736" checksum="003E91093F0B9D17" modified="2024-07-24" version="1">MPEGPVTTILRGFKVPVAVLDRFLQANGIDETCGWPPRYNTLDEPSKLLRTKLGDSKTRLFIPHRLGHRLSAFAYVAYGSIFVFAQRKILPEELPPSPPPGFAKLCNEIIGYANEQEREQPRLKPDDLTAMYVINTDDQSYWFQEPYVRKSDVRCDGCNTTFMTWVEKVNHRRDVHRSKESPIDLPNDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M0Z8</accession>
    <name>A0AAJ0M0Z8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyanovirin-N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_255292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720673.1">
        <property type="nucleotide sequence ID" value="XM_062863237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M0Z8"/>
    <dbReference type="GeneID" id="87882066"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042519940" description="Cyanovirin-N domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3304893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="21691" checksum="4C9AE0D7FA7CEF5C" modified="2024-07-24" version="1">MKLIALFTVCMSLAVALDPARPETRVNHPRRRIARSNKLTLDYTTSISTPTDQRSKATLHQVPAELVQSAVRPRGESSNAPQMQRRQLTANDFFECTNPNPSPSSADCNVIVNQVLATSQDYLFDANTCITFSFGTCQAFFCSLCETLATSSSFIGSQLDTVAALCVDNGQAGTIVGEDVPQWDAGFVRTGQGLPTYDVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M1Q0</accession>
    <name>A0AAJ0M1Q0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit DAM1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Outer kinetochore protein DAM1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0T15DRAFT_533188</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721497.1">
        <property type="nucleotide sequence ID" value="XM_062869351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M1Q0"/>
    <dbReference type="GeneID" id="87888180"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990537">
        <property type="term" value="C:mitotic spindle polar microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990758">
        <property type="term" value="P:mitotic sister chromatid biorientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013962">
        <property type="entry name" value="DASH_Dam1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28113">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28113:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08653">
        <property type="entry name" value="DASH_Dam1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3305717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="128" mass="14449" checksum="0E38B3EBFCEC089A" modified="2024-07-24" version="1">MAPDGQEQNTQRRARSTSRSRPTTPLRPSSRASLRDSARSSVHGESASFPLNAFEPAFAELSDAVADLEANMMHFQLMHESLARFSESFASFLYGLNMNAFCVDFPEAPMAESFRRMKLKEEEQQGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M1R0</accession>
    <name>A0AAJ0M1R0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">U3 small nucleolar RNA-associated protein 22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0T15DRAFT_533383</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
            <location evidence="1 5">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the NRAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721559.1">
        <property type="nucleotide sequence ID" value="XM_062869364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M1R0"/>
    <dbReference type="GeneID" id="87888193"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032545">
        <property type="term" value="C:CURI complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005554">
        <property type="entry name" value="NOL6/Upt22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035082">
        <property type="entry name" value="Nrap_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035367">
        <property type="entry name" value="Nrap_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035368">
        <property type="entry name" value="Nrap_D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035369">
        <property type="entry name" value="Nrap_D4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035370">
        <property type="entry name" value="Nrap_D5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035371">
        <property type="entry name" value="Nrap_D6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17972:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17972">
        <property type="entry name" value="NUCLEOLAR RNA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03813">
        <property type="entry name" value="Nrap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17403">
        <property type="entry name" value="Nrap_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17404">
        <property type="entry name" value="Nrap_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17405">
        <property type="entry name" value="Nrap_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17406">
        <property type="entry name" value="Nrap_D5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17407">
        <property type="entry name" value="Nrap_D6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Nrap protein" evidence="7">
        <location>
            <begin position="138"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="8">
        <location>
            <begin position="290"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="9">
        <location>
            <begin position="440"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="10">
        <location>
            <begin position="620"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="11">
        <location>
            <begin position="807"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="12">
        <location>
            <begin position="969"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1076"/>
            <end position="1099"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3305779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1130" mass="125787" checksum="A6666B07A67E6E8A" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M1U9</accession>
    <name>A0AAJ0M1U9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_213970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721679.1">
        <property type="nucleotide sequence ID" value="XM_062862707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M1U9"/>
    <dbReference type="GeneID" id="87881536"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3305899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="210" mass="23364" checksum="A47209E751985BE1" modified="2024-07-24" version="1">MDGVEEKTGRGPDLILVVGGFGCSKFLQSELCRNLGHSNVAFTGEDGMIAVKHGAAIYGALRNFVAMNQHEADQFNLPRVTNVPPTIYIRSRVARYSYGYSVPNGAWNAITWFVTKGQDVDFSATFTLPRNAFIFTIQNRPCAVIYRSPQSAPSNEEARQECRIKCERPDILGQLQSVPVRMRLMGSGMQFEVHGAGNEQETTFTVLYPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M1Y4</accession>
    <name>A0AAJ0M1Y4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_534087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3306020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721800.1">
        <property type="nucleotide sequence ID" value="XM_062869412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M1Y4"/>
    <dbReference type="GeneID" id="87888241"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009836">
        <property type="entry name" value="GRDP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34365">
        <property type="entry name" value="ENOLASE (DUF1399)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34365:SF7">
        <property type="entry name" value="GLYCINE-RICH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07173">
        <property type="entry name" value="GRDP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3306020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="525" mass="60229" checksum="6E2985D3BD99ABC4" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M2G3</accession>
    <name>A0AAJ0M2G3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_393187</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722337.1">
        <property type="nucleotide sequence ID" value="XM_062864676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M2G3"/>
    <dbReference type="GeneID" id="87883505"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040085">
        <property type="entry name" value="MJ0674-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016431">
        <property type="entry name" value="Pyrv-formate_lyase-activ_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43075">
        <property type="entry name" value="FORMATE LYASE ACTIVATING ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G15630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43075:SF1">
        <property type="entry name" value="FORMATE LYASE ACTIVATING ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G15630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004869">
        <property type="entry name" value="PflX_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01099">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="104"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="305"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR004869-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3306557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="356" mass="39741" checksum="47E4EA89230CC305" modified="2024-07-24" version="1">MRRPAALHASQLGNKRSLHLAPPFLLDDYTPRYMTLSSVDAAKKRSKAYAHLRNCNLCPRLCGVNRYETTGMCLIGHNVKVNTIAPHFGEEPCIQGHNGSGSVFFSMCNLRCVFCQNHDIAHQRNGQDLTPEELGDWYLKLQEVGNVHNINLITPEHVVPQVALSILHARDNGLTLPIVYNTSAYDSLASLELLDGLVDIYLPDFKLWFPVSSRRLLKAEDYAATARESIKAMHAQVGDLCFTADGIAKRGLLVRHLVMPGFEAESAEIMNFLANEVSKDCFVNIMEQYHPDAYVGKPKSRSKRSAADKDDSASERRYADINRAVTKDEISSVRKAAEAAGLWRFCDPPRHDGFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M2G9</accession>
    <name>A0AAJ0M2G9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LYR motif-containing protein Cup1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_395791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722084.1">
        <property type="nucleotide sequence ID" value="XM_062864799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M2G9"/>
    <dbReference type="GeneID" id="87883628"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20273">
        <property type="entry name" value="Complex1_LYR_unchar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046896">
        <property type="entry name" value="Cup1-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20263">
        <property type="entry name" value="LYRM2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LYR motif-containing protein Cup1-like N-terminal" evidence="1">
        <location>
            <begin position="16"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3306304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="360" mass="41412" checksum="198320E40F954308" modified="2024-07-24" version="1">MSRPLRIPHPETPWRLYRHLLREASYLPPIARPFVDSQIKARFRQHQEDYPGAENTEARIRQAHRELRILRAANAGDLTRMRRVLLRVFGRVGRRRRELMADLLHRDLPTNTEELQKYAAEASDIASTGRKIDWLDRWDLKKLRTFANSQIQAGLVNNPKSDLTAAQINPSKSIPTENAWGRPLTPKLARTKLKKLWKTAADKCLPPLPVEEWERLGVLAKGLVHSLPPPRRPVARSMSNDGQGNREWDWRSYATKPVAVVDRPANRRNKLLTGAVDDNTPTGDPQPIVCHKYTPRTWQRLLASIWRLTATMEKRPDGQSWKIEWGKLDFRPAPASAGDLEFFRDFPLPEKQGKKGKRGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M3D2</accession>
    <name>A0AAJ0M3D2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_574236</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723238.1">
        <property type="nucleotide sequence ID" value="XM_062870948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M3D2"/>
    <dbReference type="GeneID" id="87889777"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11887">
        <property type="entry name" value="SH3_Bbc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057402">
        <property type="entry name" value="AIM3_BBC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035552">
        <property type="entry name" value="Mti1_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050670">
        <property type="entry name" value="STAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929:SF6">
        <property type="entry name" value="SH3 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G10320)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25459">
        <property type="entry name" value="AIM3_BBC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="41"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1161"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="114"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="129"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="149"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="235"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="257"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="295"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="317"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="348"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="398"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="425"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="444"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="508"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="528"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="559"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="619"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="668"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="717"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="740"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="766"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="800"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="820"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="834"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="866"/>
            <end position="876"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3307458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1183" mass="126507" checksum="6E2DA923E577420B" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M3K5</accession>
    <name>A0AAJ0M3K5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glutamate carboxypeptidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_522567</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3307786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723566.1">
        <property type="nucleotide sequence ID" value="XM_062868637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M3K5"/>
    <dbReference type="GeneID" id="87887466"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05676">
        <property type="entry name" value="M20_dipept_like_CNDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051458">
        <property type="entry name" value="Cyt/Met_Dipeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270">
        <property type="entry name" value="BETA-ALA-HIS DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270:SF4">
        <property type="entry name" value="CARNOSINE DIPEPTIDASE 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="6">
        <location>
            <begin position="284"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3307786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="549" mass="60491" checksum="E9328E3110F36888" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M3N7</accession>
    <name>A0AAJ0M3N7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ornithine decarboxylase antizyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_549634</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with ODC and thereby sterically blocks ODC homodimerization.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ODC antizyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3307788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723568.1">
        <property type="nucleotide sequence ID" value="XM_062870223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M3N7"/>
    <dbReference type="GeneID" id="87889052"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008073">
        <property type="term" value="F:ornithine decarboxylase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045732">
        <property type="term" value="P:positive regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075523">
        <property type="term" value="P:viral translational frameshifting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002993">
        <property type="entry name" value="ODC_AZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038581">
        <property type="entry name" value="ODC_AZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10279">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE ANTIZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10279:SF10">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE ANTIZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02100">
        <property type="entry name" value="ODC_AZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0688">Ribosomal frameshifting</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="64"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3307788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="313" mass="34107" checksum="8B5E3147AB33C8EA" modified="2024-07-24" version="1">MAPMKSPRSNHTSSNYGEGIVRQANILASCYGPSGIPEVPSTGLPSPPSSPPLAALTTTNQLALTPKARSPSSRASSVGRNGSGTSAWHRRRGGAALRIREECERFFCETLRVMFLGERNATMQSSGLASVNDNFDNVNHNNNIFDHSGSNDISRNDGHGRAPVMGHYGQLTPPDDFPITGETMMGHQRRQGHDARRGITGWLEIWDYAGGSSFRGFVAEDASRGVTSLFVFFDAHSITRDMKQALVALIELAEGPLACSHMVICIERSIPEEEAKALTKGLQWAGFSLTTLDFWSSGFDVLSDRWLFMGMEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M4N8</accession>
    <name>A0AAJ0M4N8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_390154</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724455.1">
        <property type="nucleotide sequence ID" value="XM_062864525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M4N8"/>
    <dbReference type="GeneID" id="87883354"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF3">
        <property type="entry name" value="FERROPTOSIS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="5">
        <location>
            <begin position="4"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3308675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="389" mass="42107" checksum="AED4BD02E10573D7" modified="2024-07-24" version="1">MAKTIVILGASYAGIPIAHYLLKHTTAKVKGLKVIIVAPNTHMYWNVAAVRGILPDMMPDEKLFLPLAPAFSKYPSDQYEFVRGVAENVDASRNVVEVRGNDGHTKTIQYDELVIATGSSFKADMPFKNLSSTEKTKDTLHDWSRRIKSAKSIVVAGAGATGIEIAGELGQEYAVTGKKQVILVSDQELPLTSKFTRAVRETAKKELERLKVKVITNAKAAASSTSPNTITLTKPDGTTTSITADLVIPTYGITPNTSFLPPAMLDSRGFVKQTARLRAEGHDNIFVVGDAGNLEDAQGLHTDAQVVHVVKFIDARLLGSAEAEAQVPDYKPADKVVLAASLGKNRGIGQVGKMRLWGWLIAWLKGKHLGTNHAAAFVRGERTLSAKEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M6L7</accession>
    <name>A0AAJ0M6L7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome c oxidase assembly protein PET191-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_519469</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PET191 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726570.1">
        <property type="nucleotide sequence ID" value="XM_062868433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M6L7"/>
    <dbReference type="GeneID" id="87887262"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018793">
        <property type="entry name" value="Cyt_c_oxidase_assmbl_Pet191"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28627">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28627:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10203">
        <property type="entry name" value="Pet191_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="101"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3310790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="133" mass="14983" checksum="86B8EBA3C7FE26A8" modified="2024-07-24" version="1">MPSSCKELRAALAECLQQSECVMVQRHTAAECLREPLVNTLPLKCQQLKKGFGECRRGMLDMRKRFRGNQPVAFRHLEQAEKTGEGYQLYAGKSAFGGGRGETDGNEKEPQDWRDMENEKYRAALAAEKATKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M716</accession>
    <name>A0AAJ0M716_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PD-(D/E)XK nuclease-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_69627</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727079.1">
        <property type="nucleotide sequence ID" value="XM_062871222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M716"/>
    <dbReference type="GeneID" id="87890051"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046797">
        <property type="entry name" value="PDDEXK_12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20516">
        <property type="entry name" value="PDDEXK_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PD-(D/E)XK nuclease-like" evidence="1">
        <location>
            <begin position="40"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3311299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="232" mass="25934" checksum="78582B95BFEF4771" modified="2024-07-24" version="1">MTRPRLKGLKRSKSSTNWNASWSRRPCRLMTMRMVGGFWVHFPILRLVFGDQQDPDTQPDEHAVVPEAIAFAGMVKACVPQFAPDRNGLYACSYKETSTSGVSSEARTWNSARELANSGKPGGGRKVDYALLLQCRRDSQLHVAISQACFSLQSQIGGKSHVNETDYQKIQFKPIAVAIEAKRITAGGDRVVQLGLWTAAWHARMEQFRMLQAQPTRVLLQLEMAVGLYHCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M727</accession>
    <name>A0AAJ0M727_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Golgi SNAP receptor complex member 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0T15DRAFT_507860</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of several multiprotein Golgi SNARE complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the GOSR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727065.1">
        <property type="nucleotide sequence ID" value="XM_062867672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M727"/>
    <dbReference type="GeneID" id="87886501"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048219">
        <property type="term" value="P:inter-Golgi cisterna vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023601">
        <property type="entry name" value="Golgi_SNAP_su1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21094:SF2">
        <property type="entry name" value="GOLGI SNAP RECEPTOR COMPLEX MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21094">
        <property type="entry name" value="GOS-28 SNARE- RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027109">
        <property type="entry name" value="Golgi_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR027109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3311285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="220" mass="24569" checksum="C3C1072DE08FF82B" modified="2024-07-24" version="1">MATTAGQGWAQLRQQARSLESQTETSLQTYAQFSTQTNIPPKPTEEEKNAEAKRETVIGQLGRLLDSEATLTSSALKQNNLALLRDKLSEHRRDLARLRTTLQEARDRANLLGSVRDDISAYRAANPAAAEAEYMLDERARLDRSHDVADSVLSQAYAVQDSFTLQRETLANINRRITLAASQVPGINTLIGRISAKKRRDGIIMGSFIALCFLVFWFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M7C1</accession>
    <name>A0AAJ0M7C1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_78855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727302.1">
        <property type="nucleotide sequence ID" value="XM_062871316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M7C1"/>
    <dbReference type="GeneID" id="87890145"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42083">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42083:SF1">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3311522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="154" mass="17568" checksum="8E7209613A64E93C" modified="2024-07-24" version="1">MALGDTSRAYLFFTLLHFFQFALAITVCALYGINLDRARKAGAHADGRWVYAEVVGGLSALTAILYCIPFILRFALVWAWNLILFILWIALFGVFGRLYIHEDAGGNGDVQRMKNAVWVVLTSAILWLIGVLAHFIYWWGHRERRSRFTSRAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GKH0</accession>
    <name>A0AAJ0GKH0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal L28e protein family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_315548</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717340.1">
        <property type="nucleotide sequence ID" value="XM_062863983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GKH0"/>
    <dbReference type="GeneID" id="87882812"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.110:FF:000002">
        <property type="entry name" value="60S ribosomal protein L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002672">
        <property type="entry name" value="Ribosomal_eL28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029004">
        <property type="entry name" value="Ribosomal_eL28/Mak16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10544">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01778">
        <property type="entry name" value="Ribosomal_L28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal eL28/Mak16" evidence="5">
        <location>
            <begin position="8"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="142"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3301560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="153" mass="16497" checksum="ADA40587B683C9B8" modified="2024-07-24" version="1">MSNVSADLIWEITRSQNAYLVKRKTGGAPQLSRDPLNLTNVHSRKFAGFVNDKALGIVPGEKGGIQVISKKPASANKPAAGLYTVTYGANKSTRKTYKAVANQVAKNSYRPDLRQAAVARASAIRRAQSLRIKPEPERKLRGAAARKAAAAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GLA9</accession>
    <name>A0AAJ0GLA9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Protein-S-isoprenylcysteine O-methyltransferase</fullName>
            <ecNumber evidence="3 10">2.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0T15DRAFT_288893</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12125"/>
            <dbReference type="Rhea" id="RHEA-COMP:12126"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90510"/>
            <dbReference type="ChEBI" id="CHEBI:90511"/>
            <dbReference type="EC" id="2.1.1.100"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endoplasmic reticulum membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.100" evidence="3 10"/>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717788.1">
        <property type="nucleotide sequence ID" value="XM_062863683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GLA9"/>
    <dbReference type="GeneID" id="87882512"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025770">
        <property type="entry name" value="PPMT_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714">
        <property type="entry name" value="PROTEIN-S ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714:SF9">
        <property type="entry name" value="PROTEIN-S-ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51564">
        <property type="entry name" value="SAM_ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3302008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="266" mass="30143" checksum="215FCA32BAA5611A" modified="2024-07-24" version="1">MSRMDSSSSSRRRPWSPEIDNPNSSQDDASLYLPHQPKSLAGIAIRSFCLGIALTLGLVATLTIYFYTSSPLWRLPFFLAALSLFHFLEFWTTAAYNTRAAEVSSFLLTSNWPAYAIAHSFATLECLLTHLLWPNARWAPFGLGPALTLAGWALVVLGQAVRSVAMIHAGRSFNHLVQYRRQSGHVLVTTGIYGVLRHPSYFGFYWWALGTQMVMGNVVSFVGYAVVLWRFFSSRIHYEEELLVAFFGDEYVNYRRRVRTLIPFVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GLE2</accession>
    <name>A0AAJ0GLE2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_291644</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717875.1">
        <property type="nucleotide sequence ID" value="XM_062863720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GLE2"/>
    <dbReference type="GeneID" id="87882549"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3302095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="175" mass="19879" checksum="5DDCCF4FFE3DEEF3" modified="2024-07-24" version="1">MRWIYPGVIRGRHVLARRFRLFCSAGRLPTPDLLARTPCATSRRLQPLIIPARSTTSSEVPVRGWTRRFAPRRFWASGLGASILGAKSGVSLSKDKKVNVSGSQIGVFTDYMQNTSQCDTIRARMRVHFKSSSCGTASTRLYSIFPYLLTIDAWDTRHFREQHERKAEQTFKQAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GLS3</accession>
    <name>A0AAJ0GLS3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Probable vacuolar protein sorting-associated protein 16 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_542567</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Essential for vacuolar protein sorting. Required for vacuole biogenesis, stability and to maintain vacuole morphology.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the VPS16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718081.1">
        <property type="nucleotide sequence ID" value="XM_062869929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GLS3"/>
    <dbReference type="GeneID" id="87888758"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000635">
        <property type="entry name" value="Probable vacuolar protein sorting-associated protein 16 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.780">
        <property type="entry name" value="Vps16, C-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016534">
        <property type="entry name" value="VPS16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006925">
        <property type="entry name" value="Vps16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038132">
        <property type="entry name" value="Vps16_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006926">
        <property type="entry name" value="Vps16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12811">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12811:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04840">
        <property type="entry name" value="Vps16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04841">
        <property type="entry name" value="Vps16_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007949">
        <property type="entry name" value="VPS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vps16 N-terminal" evidence="4">
        <location>
            <begin position="6"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Vps16 C-terminal" evidence="3">
        <location>
            <begin position="504"/>
            <end position="813"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR007949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3302301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="834" mass="93500" checksum="8E2CC17D83E69F19" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GM26</accession>
    <name>A0AAJ0GM26_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Store-operated calcium entry-associated regulatory factor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Transmembrane protein 66</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B0T15DRAFT_505451</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SARAF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718195.1">
        <property type="nucleotide sequence ID" value="XM_062867527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GM26"/>
    <dbReference type="GeneID" id="87886356"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006816">
        <property type="term" value="P:calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001256">
        <property type="term" value="P:regulation of store-operated calcium entry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009567">
        <property type="entry name" value="SARAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15929">
        <property type="entry name" value="STORE-OPERATED CALCIUM ENTRY-ASSOCIATED REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15929:SF0">
        <property type="entry name" value="STORE-OPERATED CALCIUM ENTRY-ASSOCIATED REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06682">
        <property type="entry name" value="SARAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0732">Signal</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042512841" description="Store-operated calcium entry-associated regulatory factor" evidence="16">
        <location>
            <begin position="25"/>
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        </location>
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            <begin position="168"/>
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        </location>
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        </location>
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            <begin position="206"/>
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        </location>
    </feature>
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            <begin position="240"/>
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        </location>
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    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
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        </location>
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        </location>
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        </source>
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        </source>
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        </source>
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        </source>
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        </source>
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        </source>
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        </source>
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        </source>
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        </source>
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        </source>
    </evidence>
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        </source>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3302415.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="335" mass="34241" checksum="080E327550BB3905" modified="2024-07-24" version="1">MRLLDPSLSPILLALLALSSPTLAARPKDAILLSEVKSLTLRSPGQTTSRRVPAIPQLRCLSLRALCRLAEPIQTMRCTNQGSSYTSQDIEWACAATVPSTVRLDRTEVICEGYDHADDAYVLKGSCGVEYTVRLTEEGERKYPELLRGGGGGGGDNDDNAQVGWAEMLFGLVFVGVLGWIVYSACVRARENSRVGGGQNRRRRGGGGGGGGGGGWGPGWGPGGGGGGGGGGGGGGGWDDPPPPYPGSGPKPSSSTATEQGWRPGFWSGLAGGAAAGYMAGNRGQRNNDRNYGTGGGAGSWGSGSGWGSGRSSSSSSSGSAPRHESTGYGSTSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GM54</accession>
    <name>A0AAJ0GM54_9PEZI</name>
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        <submittedName>
            <fullName evidence="8">Sas10 C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_505525</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
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                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
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                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062867530.1"/>
    </dbReference>
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        <property type="term" value="C:small-subunit processome"/>
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    </dbReference>
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        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Sas10_C_dom"/>
    </dbReference>
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        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 10-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="Sas10"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sas10_Utp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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            <end position="32"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="569"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010979"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF09368"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3302498.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="627" mass="70199" checksum="FFFF8F1CCA4313CC" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ0GME7_9PEZI</name>
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            <fullName evidence="2">25S rRNA (uridine-N(3))-methyltransferase BMT5-like domain-containing protein</fullName>
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    </protein>
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        <name evidence="3" type="ORF">B0T15DRAFT_422464</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
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                <person name="Calhoun S."/>
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                <person name="Kuo A."/>
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                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718175.1">
        <property type="nucleotide sequence ID" value="XM_062865572.1"/>
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    <dbReference type="GeneID" id="87884401"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070042">
        <property type="term" value="F:rRNA (uridine-N3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019446">
        <property type="entry name" value="BMT5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF26">
        <property type="entry name" value="FERREDOXIN-FOLD ANTICODON-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10354">
        <property type="entry name" value="BMT5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="25S rRNA (uridine-N(3))-methyltransferase BMT5-like" evidence="2">
        <location>
            <begin position="76"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3302395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="290" mass="31870" checksum="D9581B7F01B49631" modified="2024-07-24" version="1" fragment="single">MGKRHGLLRHAAKAAKEQAQKKVAPGSRSGPGSKPVTKTQPGAGPPAAKKQKTGNNSRVQQNQKPTIPFSPADSILLVGEGDLSFAASLIAHHKCTDVTATVLEKDFAELSAKYPHVSSNIAVIDNPFNPNCRLLYGIDARKLHPPFTTSTTTTTSNKENKQQRQGAMKRIIFNFPHTGGKSTDVNRQVRHNQELLVDFFRRAQHSLAPGGTIVVTLFEGEPYTLWNIRDLARHAGLQVQRSFRFVAAAYPGYGHARTLGVVKNKRGEVARHAWKGEERPARSYVFVRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GMN8</accession>
    <name>A0AAJ0GMN8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_315069</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718566.1">
        <property type="nucleotide sequence ID" value="XM_062863978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GMN8"/>
    <dbReference type="GeneID" id="87882807"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF8">
        <property type="entry name" value="CYTOCHROME P450 2E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042544974" evidence="7">
        <location>
            <begin position="18"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="567"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3302786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="592" mass="67825" checksum="80DF37408B6A2B8B" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GNN4</accession>
    <name>A0AAJ0GNN4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_270033</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719072.1">
        <property type="nucleotide sequence ID" value="XM_062863450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GNN4"/>
    <dbReference type="GeneID" id="87882279"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF18">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G12480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3303292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="306" mass="31755" checksum="296AE1B770C3A43E" modified="2024-07-24" version="1">MSQTAGSINPGELFSVKGLVALVTGGGTGIGLMIAHALADAGAERVYIAGRRMDVLQEAAAAAASANRAGVIVPLCCDITSKASLEGAVATVERDSGYLHLVVCNAGIAGPQVRPPVAGETSLEEWRQRQMEDVEGFTDTFRVNSSSVWFTAMAFLKLLDEGNRKPFDQQVSSQVVVVSSIAGFNKHATGGYAYGPSKAAATHIAKMLSNVLPTWGIRANCICPGLFPSEMAAPIVRRATGGGELGDADDSTVTLDTSVVPLGRMGDNKDMAGQILYLTSRAGAYLNGNTIVVDGGRLGTFPSAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GNZ9</accession>
    <name>A0AAJ0GNZ9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_365181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719005.1">
        <property type="nucleotide sequence ID" value="XM_062864169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GNZ9"/>
    <dbReference type="GeneID" id="87882998"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="259"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3303225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="259" mass="29287" checksum="B9C48702B197C5AF" modified="2024-07-24" version="1" fragment="single">PPVFFPGSKKWFIPNHKRSSADLSPYLSERLNDHMVPFELVLAGDGELGTTRFIRFDAPFALFVAALAYNKAHLARECFADLYITQFPLSDLPKELQDDFPMPEFLAAADPAPVDNAVPDVYSSSLWLGLEPTYTPWHCDPNHNLFCQLAGSKVIRLMPPEAGLMLFQKVKRGLGGPGSPFIRGEEMMQGPERKAFFDAVWSAAPPEGMLEVELRPRDVLYLNKHWWHSVRSVGDSGRLNASVNWWFQWRNLSPSRGWG</sequence>
</entry>
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            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719567.1">
        <property type="nucleotide sequence ID" value="XM_062869845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GPK3"/>
    <dbReference type="GeneID" id="87888674"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3303787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="196" mass="21623" checksum="A8EDAE7334EE5705" modified="2024-07-24" version="1">MQIQFKEDNDDIRNEIRIRETLIGRLLEARDIDTEMMRRFHVVPIQAVVLADGAASGRWAPGSVAGGLMPYCGPPLERFAIDEEKATELPVTGRQLQELVQAVRDLDGCGVKLGWREAAYGGIVFQSGTGGGEGRLLFADFGSLSEIGIVWGKKETKSMGRLLRWCAQRAHPLRNDSGARQCVLDMARKLESVTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GPR5</accession>
    <name>A0AAJ0GPR5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RTA1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_223226</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3303867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719647.1">
        <property type="nucleotide sequence ID" value="XM_062862839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GPR5"/>
    <dbReference type="GeneID" id="87881668"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF1">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3303867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="298" mass="33422" checksum="DFCB11E8137794C9" modified="2024-07-24" version="1">MYLPIREDAAAPPVNPFKLYHYDPSIAGAVVVLLLFLGTTALHFWQLFRARCWFMLPLAIGGIFEFVGYAARAKSGAESPNWTLGPYIIQAILLLVAPALFAATIYMQLGRIILLLHGESRALIKKKWLTKIFVTGDVLSFFLQAGGGGYQATGTLEALNNGATVIIVGLFVQLVFFGVFMVVAVAFILSIRRAPTSQSQTHSSIWRRQMFALCVGSMLIMVRSVFRAIEYLQGFDGYLLSHEAYLYVFDAVLMFLVMVLFNYIHPSEVAELLVREDREWKMGILPDNRYDTRLDSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GPU5</accession>
    <name>A0AAJ0GPU5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">alcohol dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="9">1.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0T15DRAFT_402686</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a primary alcohol + NADP(+) = an aldehyde + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15937"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:15938"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:15939"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.2" evidence="9"/>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719470.1">
        <property type="nucleotide sequence ID" value="XM_062865174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GPU5"/>
    <dbReference type="GeneID" id="87884003"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008106">
        <property type="term" value="F:alcohol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000158">
        <property type="entry name" value="Zinc-binding alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="12">
        <location>
            <begin position="18"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3303690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="360" mass="38779" checksum="69ABB2073CD8BB3C" modified="2024-07-24" version="1">MYPDTFEGFAIPAADQWTQPRRIEFKPKPFGDYDIDVKITCCGVCGSDLHTATGGWGNKNWPIIPGHEIVGTAVKVGPKVTTVKVGDRVGVGAQISACLDCAQCKEGNETYCKKQQDTYNSFYPDGTLAHGGYSSHIRAHEHFTFPIPDALPSELAAPMLCAGLTAYSPLVRNGVGPGKKVGIIGIGGIGHFGILFAKALGASVWAISRGTSKKADALAMGADGFLATQEKGWNTGPELEMTFDMLLCTASADDDGFDLAAYLSLLKVHGRFISVGLPEGDGWRVRPMSLLANGCLIGAAHLGSRRETLDMLRLAAERGIKSWVETIPVGEKGVGEALERLHNNDVRYRFTLVDYDKQFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQ28</accession>
    <name>A0AAJ0GQ28_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin-related protein 2/3 complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_227895</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ARPC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719824.1">
        <property type="nucleotide sequence ID" value="XM_062862905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQ28"/>
    <dbReference type="GeneID" id="87881734"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.190">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006789">
        <property type="entry name" value="ARPC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036743">
        <property type="entry name" value="ARPC5_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12644">
        <property type="entry name" value="ARP2/3 COMPLEX 16 KD SUBUNIT P16-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04699">
        <property type="entry name" value="P16-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039096">
        <property type="entry name" value="p16-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69103">
        <property type="entry name" value="Arp2/3 complex 16 kDa subunit ARPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="136"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3304044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="204" mass="21943" checksum="176CA261935B82A7" modified="2024-07-24" version="1">MSIIREHTQATLSDAWRTINIDALQEDSSVNFDTATLHPPQPEISEGDARQIQSQVRQLLRGGDAEGALRGCLETPVYNGGELARETHLQTVIEVLQSIKASEMTPMLQRIYSSPGGSECLDVLMKYLYKGMAGSSSSSAGSAPRTPSRMTPQPTGFSQVGARPGAPAESTGAAMSVLLSWHEKVVEVAGLGCIGRVMTDWRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQB2</accession>
    <name>A0AAJ0GQB2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Double-strand break repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">B0T15DRAFT_485738</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Core component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases. The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage. Within the MRN complex, MRE11 possesses both single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. MRE11 first endonucleolytically cleaves the 5' strand at DNA DSB ends to prevent non-homologous end joining (NHEJ) and licence HR. It then generates a single-stranded DNA gap via 3' to 5' exonucleolytic degradation, which is required for single-strand invasion and recombination.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the MRN complex composed of two heterodimers RAD50 and MRE11 associated with a single NBS1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 17">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17 19">Belongs to the MRE11/RAD32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3303955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719735.1">
        <property type="nucleotide sequence ID" value="XM_062866308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQB2"/>
    <dbReference type="GeneID" id="87885137"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097552">
        <property type="term" value="P:mitochondrial double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000011">
        <property type="entry name" value="Double-strand break repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.110">
        <property type="entry name" value="Mre11, capping domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003701">
        <property type="entry name" value="Mre11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038487">
        <property type="entry name" value="Mre11_capping_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007281">
        <property type="entry name" value="Mre11_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00583">
        <property type="entry name" value="mre11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10139">
        <property type="entry name" value="DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10139:SF1">
        <property type="entry name" value="DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04152">
        <property type="entry name" value="Mre11_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000882">
        <property type="entry name" value="DSB_repair_MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01347">
        <property type="entry name" value="Mre11_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 17 19" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 17 19" id="KW-0234">DNA repair</keyword>
    <keyword evidence="22" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 17 19" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11 17 19" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10 17 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 17 19" id="KW-0464">Manganese</keyword>
    <keyword evidence="15 17 19" id="KW-0469">Meiosis</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 17 19" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14 17 19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mre11 DNA-binding" evidence="21">
        <location>
            <begin position="290"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="516"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="613"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="642"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="688"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="709"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="18">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00064981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR000882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000882-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM01347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAK3303955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="731" mass="81982" checksum="7B5FA31EBE3A626E" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQN2</accession>
    <name>A0AAJ0GQN2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_238361</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720139.1">
        <property type="nucleotide sequence ID" value="XM_062863040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQN2"/>
    <dbReference type="GeneID" id="87881869"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF5">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="472"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3304359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="532" mass="60683" checksum="71D84F881C5EA09D" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQP0</accession>
    <name>A0AAJ0GQP0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_536344</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720154.1">
        <property type="nucleotide sequence ID" value="XM_062869543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQP0"/>
    <dbReference type="GeneID" id="87888372"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3304374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="73" mass="8528" checksum="94D5ECD442B8AACF" modified="2024-07-24" version="1">MSTYPLFKGLPLSFAVVLYNLAPLHLPPLSMISCRHFHPYPFRRPERAPPMRAFHCHCREVTRTQSLGTYRDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQY9</accession>
    <name>A0AAJ0GQY9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine-threonine rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_575959</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720317.1">
        <property type="nucleotide sequence ID" value="XM_062871009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQY9"/>
    <dbReference type="GeneID" id="87889838"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00920">
        <property type="entry name" value="Cupredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052953">
        <property type="entry name" value="Ser-rich/MCO-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883:SF4">
        <property type="entry name" value="CUPREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883">
        <property type="entry name" value="SERINE-RICH PROTEIN, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042540708" description="Serine-threonine rich protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3304537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="378" mass="37122" checksum="00267C9941E38AB8" modified="2024-07-24" version="1">MKFSVATAMVLGMAPLAMGKAVHNLYPGRRSMHAQEVSVNKVSTNSVKASQEQLAELQRLIGLQTGQGTTINFLWVNLGGGAATTVVGSASTVTVTQTVVGGEATAPPAVTTGEAATTTAAAPATGTTVVAGGATHSVTVGGPQGLAFDPPQLSANPGDTVIFTFLSQNHTATQSTFDKPCEPLTGGMDSGFQANPNNTINPPPQVAMQVMVSTPLWFYCRQKGHCGKGMVFSINPTAEKTAAQFQALAIQQAGSGTGSAITGGGNANATAGAGTDASASASASASPSASADAGNVGGDAAASTSVEASTPAVTEGATATSGGIVTGTGTIGANGACVCAVQCSVGGFPNAQMQGRDSFGGWGGAVPVPAVEAARFRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GR02</accession>
    <name>A0AAJ0GR02_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">5'-3' exoribonuclease</fullName>
            <ecNumber evidence="17">3.1.13.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">B0T15DRAFT_436950</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Possesses 5'-&gt;3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II.</text>
    </comment>
    <comment type="function">
        <text evidence="15">Possesses 5'-&gt;3' exoribonuclease activity. Required for the processing of nuclear mRNA and rRNA precursors. May promote the termination of transcription by RNA polymerase II. Essential for vegetative cell growth and chromosome segregation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Interacts with RAI1; the interaction is direct, stabilizes RAT1 protein structure and may stimulate its exoribonuclease activity. The interaction also stimulates RAI1 pyrophosphohydrolase activity, probably by recruiting it to mRNA substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.-" evidence="17"/>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720276.1">
        <property type="nucleotide sequence ID" value="XM_062865837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GR02"/>
    <dbReference type="GeneID" id="87884666"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18673">
        <property type="entry name" value="PIN_XRN1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1050:FF:000002">
        <property type="entry name" value="5'-3' exoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12390:FF:000003">
        <property type="entry name" value="5'-3' exoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12390:FF:000005">
        <property type="entry name" value="5'-3' exoribonuclease 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027073">
        <property type="entry name" value="5_3_exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041412">
        <property type="entry name" value="Xrn1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004859">
        <property type="entry name" value="Xrn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017151">
        <property type="entry name" value="Xrn2/3/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341:SF41">
        <property type="entry name" value="5'-3' EXORIBONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341">
        <property type="entry name" value="5'-&gt;3' EXORIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17846">
        <property type="entry name" value="XRN_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03159">
        <property type="entry name" value="XRN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037239">
        <property type="entry name" value="Exonuclease_Xrn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10 17" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="8 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 17" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 17" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0806">Transcription termination</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="18" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="20">
        <location>
            <begin position="271"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="412"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="514"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="849"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="925"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="412"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="516"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="19">
        <location>
            <begin position="889"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="931"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="19">
        <location>
            <begin position="960"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1003"/>
            <end position="1025"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00046137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00046943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR037239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAK3304496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1025" mass="114831" checksum="08B5273B326D5D5B" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GRD4</accession>
    <name>A0AAJ0GRD4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NUC173 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_436981</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720290.1">
        <property type="nucleotide sequence ID" value="XM_062865838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GRD4"/>
    <dbReference type="GeneID" id="87884667"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM-like"/>
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        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
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        <location>
            <begin position="15"/>
            <end position="266"/>
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    <feature type="domain" description="RRP12 HEAT" evidence="6">
        <location>
            <begin position="335"/>
            <end position="626"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="982"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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        <location>
            <begin position="1152"/>
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        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="181"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="987"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1091"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1153"/>
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        </location>
    </feature>
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        <location>
            <begin position="1169"/>
            <end position="1184"/>
        </location>
    </feature>
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        <location>
            <begin position="1210"/>
            <end position="1230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007690"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3304510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1263" mass="137696" checksum="C29A30C9DA39C365" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GRF8</accession>
    <name>A0AAJ0GRF8_9PEZI</name>
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        <submittedName>
            <fullName evidence="6">Dip2/Utp12 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="6" type="ORF">B0T15DRAFT_252969</name>
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    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UTP5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="87882034"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052414">
        <property type="entry name" value="U3_snoRNA-assoc_WDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44267">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44267:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="5">
        <location>
            <begin position="171"/>
            <end position="273"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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            <end position="411"/>
        </location>
    </feature>
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        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
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        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3304779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ0GSJ7_9PEZI</name>
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        <recommendedName>
            <fullName evidence="3">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_554966</name>
    </gene>
    <organism evidence="4 5">
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            <taxon>Ascomycota</taxon>
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            <taxon>Sordariomycetes</taxon>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720880.1">
        <property type="nucleotide sequence ID" value="XM_062870374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GSJ7"/>
    <dbReference type="GeneID" id="87889203"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001638">
        <property type="entry name" value="NACHT and WD40 domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF13">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NACHT" evidence="3">
        <location>
            <begin position="303"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="2">
        <location>
            <begin position="831"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="2">
        <location>
            <begin position="873"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="2">
        <location>
            <begin position="915"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="943"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3305100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="943" mass="106760" checksum="3DB78966C0E97F0F" modified="2024-07-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GSW7</accession>
    <name>A0AAJ0GSW7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B0T15DRAFT_493496</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721100.1">
        <property type="nucleotide sequence ID" value="XM_062866948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GSW7"/>
    <dbReference type="GeneID" id="87885777"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000016">
        <property type="entry name" value="Solute carrier family 25 member 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 15" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="44"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="142"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="246"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK3305320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="348" mass="38304" checksum="F0ED7D2684D38074" modified="2024-07-24" version="1">MSAVQSTKSNEGSEPKPELATPTTVPSSSKKLSLFDRFRAAISEPVVAAFCAGGVAGAVSRTVVSPLERLKILFQVQSAGREAYQLSVGKALAKMWREEGWRGFMRGNGTNCIRIVPYSAVQFGSYNFYKKHFFERHPGDSLTPMSRLTCGGLAGITSVTFTYPLDIVRTRLSIQSASFAELGEKPKKLPGMWQTMVMMYRTEGGFTALYRGIVPTVAGVAPYVGLNFMTYEFVRQYLTLDGEQNPSAVRKLAAGAISGAVAQTCTYPFDVLRRRFQINTMSGMGYQYKSIPEAVRLIVAQEGIKGLYKGIVPNLLKVAPSMASSWLSFEICRDFFVSLKPEETPLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GTM3</accession>
    <name>A0AAJ0GTM3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Snf7 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_533752</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721669.1">
        <property type="nucleotide sequence ID" value="XM_062869382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GTM3"/>
    <dbReference type="GeneID" id="87888211"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF12">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="58"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3305889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="215" mass="23896" checksum="EF795A35C13122D5" modified="2024-07-24" version="1">MNRLFGTTAPKAPKPTLNSAINNLDTRIASIDVKLAAINAELQGYQTKLSKMREGPGKTALKQKALKVLQRRKQYEAQRDQLTSQVWNMEQAQTMQDNLKNTMVTIDALKSTNKALKKEYGKVDIDKIERLQDEMADLLDVGNEIQESLARSYDVPDDVDEAELDAELEALGQEVELEREMAGTEGALPSFMQDEVPEFIDEPPATTGKVKEAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GTV8</accession>
    <name>A0AAJ0GTV8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Orc1-like AAA ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_502896</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721640.1">
        <property type="nucleotide sequence ID" value="XM_062867447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GTV8"/>
    <dbReference type="GeneID" id="87886276"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056808">
        <property type="entry name" value="HTH_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36168">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36168:SF1">
        <property type="entry name" value="ORC1-LIKE AAA ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24913">
        <property type="entry name" value="WHD_AAA_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Orc1-like AAA ATPase" evidence="3">
        <location>
            <begin position="168"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="AAA protein C-terminal winged helix" evidence="4">
        <location>
            <begin position="397"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3305860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="563" mass="63318" checksum="FB25DAFE57032D1C" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GU03</accession>
    <name>A0AAJ0GU03_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Capsule polysaccharide biosynthesis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_534446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3306126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721906.1">
        <property type="nucleotide sequence ID" value="XM_062869439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GU03"/>
    <dbReference type="GeneID" id="87888268"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008441">
        <property type="entry name" value="AfumC-like_glycosyl_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05704">
        <property type="entry name" value="Caps_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3306126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="425" mass="46759" checksum="8FBF98B853A891FE" modified="2024-07-24" version="1">MSWQHDLPEGTRLRPSSAQDPRTDSEIIAALTSPPREVTSQKNIWAFWDKGFSQLHGWQQRNIIGWVRKLGPTGWTVRVLDNVRGSPANVFHYLDYNNDNSTTLPVPEAVVANGSGGSNLGPHSGQHMSDLVRLPLLHRYGGIYLDVGVMLLGDIDKSLWQPIADASTAYRIGGFAHQHRANSWGSMQNFCIAAQAGEELLARWQRIMVAAWSGHSNSNSSSEGLSRHPVFDGVPSAINPRVLMTIQPGSEQRLLDYWVNLLAWEKLKVTIDSTSAFNGPEYVRKHVLLLDPMQEAFAAEVRTRLNTARLFALLTCPRDINKPVDVVGGGVGGGVDPELHAEAKALVEYLLSSSTLLKLYHGHGYMLAPPLATFWEAPGNEDADARPGTFGELLRYGGEVVDQLREVRPIVLPAYDGPVLRGTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GUG0</accession>
    <name>A0AAJ0GUG0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_500994</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
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                <person name="Barry K."/>
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                <person name="Grigoriev I.V."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062867389.1"/>
    </dbReference>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
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                <person name="Ament-Velasquez S.L."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
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                <person name="Steindorff A."/>
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                <person name="Martin F."/>
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                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062861860.1"/>
    </dbReference>
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    <proteinExistence type="predicted"/>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3306403.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GUP1</accession>
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            <fullName evidence="5 6">Tyrosinase copper-binding domain-containing protein</fullName>
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    </protein>
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    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
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                <person name="Kruys A."/>
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                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
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                <person name="Hiltunen Thoren M."/>
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            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062868973.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
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        <property type="entry name" value="Tyrosinase_Cu-bd"/>
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        <property type="entry name" value="N-ACETYL-6-HYDROXYTRYPTOPHAN OXIDASE IVOB-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
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    </dbReference>
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        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="TYROSINASE"/>
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        <property type="entry name" value="Di-copper centre-containing domain"/>
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    </dbReference>
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        <property type="entry name" value="TYROSINASE_1"/>
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    </dbReference>
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        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042569966" description="Tyrosinase copper-binding domain-containing protein" evidence="4">
        <location>
            <begin position="19"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="5">
        <location>
            <begin position="257"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="6">
        <location>
            <begin position="409"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="40"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="49"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="125"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3306517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="485" mass="51470" checksum="50A1609D3109B13E" modified="2024-07-24" version="1">MHIASLAVGALLLGASHAAVTIVVTATTTICPVPRPTRTCDASSVDFASTDGTTTRGLSTSSTSAEGTTQGLSTSSSSSTSVQQVSISPTSTEQVSISSTTQTSWSSSVVPPPSQTTLLTRTKESSVVSTSTTGKASSASSSSKPSSASSSSTAAAEPTSIPRAYPADVVDKLRDSTVDKLKTYLEGQPSDTGCTLENASVRREWSDLSVAEREQYIAAVKCLQSASPKSPEQLVPGARSRFDDFVATHINQTNSIHNTANFLSWHRYYVWTYEKALREECGYSGFQPYWNWDRYAADPANSPLFNGNASSMSGNSKNGACVSSGPFANFQVNLGPGLSLKYNPRCLKRDISKSQAAQTTADKTYALITRSRDIASFQDTMQGVPGVHAGGHFTIGGDPGSDIFASPGDPVFYLHHAMIDRVWWIWQMQDPSSRLTQVAGSVAGSRRQGKGTDLVDLGINAPAVAINDLLDTMGGLDGQMCYIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GUQ6</accession>
    <name>A0AAJ0GUQ6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_492062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722303.1">
        <property type="nucleotide sequence ID" value="XM_062866832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GUQ6"/>
    <dbReference type="GeneID" id="87885661"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="397"/>
        </location>
    </feature>
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        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
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            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="327"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3306523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="397" mass="43196" checksum="C6EC601C1947918C" modified="2024-07-24" version="1">MPRQLPWKVGAAATKQTPSRPKAAASPAPSAGRSPAPSHRPTPRPKAESTPEPSRRARRSLALSSGIYSPTADHVTTLTSEPARSPSTSPPPEPPKEEFMIEGVDHDDKYRMVEDEFLAVAGEFTRHLHAAEYQRLRGLAKSQNAETIQNISRPVTGEMTDLVKRRHAALDAASKQRKGIASTLGKRAKNEEEGSTRRALTSLQGLMDSPRKQAAPLSLTTGSRPGTSSRDAMDASPSRRRHEVKGLLRTSSSLVSDGKYGGQAVRFKREPTPDSDDGDDDLDNQPSWRPKSGVRHPDQATETSAPRSAVATPPIRSKSEPSAPNNPLRAAGAAPRQALAHGAPRSEATDAPNDGDDDFFSRLRARRTEQKRRRETKAQERNIKSETQTPLDEIPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GUT2</accession>
    <name>A0AAJ0GUT2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_509757</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722150.1">
        <property type="nucleotide sequence ID" value="XM_062867808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GUT2"/>
    <dbReference type="GeneID" id="87886637"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051430">
        <property type="entry name" value="Fungal_TF_Env_Response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944:SF131">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="44"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="86"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="773"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3306370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="843" mass="93011" checksum="70260C3CEFBDD04F" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GVC5</accession>
    <name>A0AAJ0GVC5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CSN8/PSMD8/EIF3K domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_527509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722320.1">
        <property type="nucleotide sequence ID" value="XM_062868977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GVC5"/>
    <dbReference type="GeneID" id="87887806"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39398:SF1">
        <property type="entry name" value="CSN8_PSMD8_EIF3K DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39398">
        <property type="entry name" value="YALI0F14311P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3306540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="350" mass="38809" checksum="CAF8F6DE63FA2F6C" modified="2024-07-24" version="1">MQRKSGRASSGHLSRLKPVEHDPLTEYGLPSKGEKRLLSTKVQEAYYTKIIERYLAFCTEAGDREGLQKQFARLAIADRGSSAAASPLPPPATSPSKLRPLPSNDKVSQIFSALRKLREALVASHRTDDFATQVYLFSARLGILASSYETYYPSLLHLLRRHQQAQRQQRQQQAHIPPSATTPTSTGRPSSSSSSSSQPNNSGVSSSSASGDLTSVEYHEVTAYLVLDAACRRADLAEAYALRHAHRLRDPKIDVILASLVGDNWVVWRRVKKQVDGYRVRLMEFAEPQVRAHTLKAFGRAHLSVPLGVLEAQTGASWAELRERFGVGWELGEGEGDERRVVIRKVQARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GVQ1</accession>
    <name>A0AAJ0GVQ1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_160918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722778.1">
        <property type="nucleotide sequence ID" value="XM_062862104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GVQ1"/>
    <dbReference type="GeneID" id="87880933"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3306998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="206" mass="22632" checksum="3176786AB9947C0F" modified="2024-07-24" version="1">MADRMGGHERNMLHALMLPQPQGGRYPTNNQVHSHMRLPVHVFFVFCQLSSTDVVVLVQGIIVGQGCRKHPGRQGGDTSGRRRGPVSSVGRSGVGSSRGPGEASTVRPIDNVPARAQTWYLQCVCKSLVGASSSWLGWDWEGLRRCGSHRWALQVTLGYVCPLPITTHGLPMLWNSSIHRWLRVHGGMQGGQLTPSVIYPCRRPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GW98</accession>
    <name>A0AAJ0GW98_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_168329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723024.1">
        <property type="nucleotide sequence ID" value="XM_062862194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GW98"/>
    <dbReference type="GeneID" id="87881023"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3307244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="260" mass="28285" checksum="CD04981482BA6F02" modified="2024-07-24" version="1">MHQMLDKAFVELKHAGLFTSAAGVEDEAYEDDDYKDGGEEEQMEEEMEEMGEDVMKQDSGEDEVMEVGEPRHDEPAATPARSERAMLPGRAMSRVPGLASGAPLCRALHRRSALCLPRSEADAQSSPERGDAGTSFVVKASNDLSAYKDKGQPVYDFKIYDLDGHRVTRCAKTTIVMDSSSTLLHGAFLFLKVNGRDSRRQARAGSSRFPSPSLREEGSVDGRTQKSSEPITAQQAMVSGDSALPPTDQLDVISPESIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GWC6</accession>
    <name>A0AAJ0GWC6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Very-long-chain 3-oxoacyl-CoA reductase</fullName>
            <ecNumber evidence="12">1.1.1.330</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">3-ketoacyl-CoA reductase</fullName>
            <shortName evidence="12">3-ketoreductase</shortName>
            <shortName evidence="12">KAR</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Microsomal beta-keto-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0T15DRAFT_501875</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3-ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP(+) = a very-long-chain 3-oxoacyl-CoA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85440"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="EC" id="1.1.1.330"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Endoplasmic reticulum membrane</location>
            <topology evidence="12">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.330" evidence="12"/>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723137.1">
        <property type="nucleotide sequence ID" value="XM_062867406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GWC6"/>
    <dbReference type="GeneID" id="87886235"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045703">
        <property type="term" value="F:ketoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141040">
        <property type="term" value="F:very-long-chain 3-oxoacyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05356">
        <property type="entry name" value="17beta-HSD1_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000317">
        <property type="entry name" value="Very-long-chain 3-oxoacyl-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03107">
        <property type="entry name" value="3_ketoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027533">
        <property type="entry name" value="3_ketoreductase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43086:SF2">
        <property type="entry name" value="HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43086">
        <property type="entry name" value="VERY-LONG-CHAIN 3-OXOOACYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000126">
        <property type="entry name" value="11-beta-HSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 12" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0521">NADP</keyword>
    <keyword evidence="8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3307357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="344" mass="38062" checksum="551CB8C16F961439" modified="2024-07-24" version="1">MAFNLNFTRQESLDKAIELWTSLPQGAQWALAGLGALSLARGALSFLQLLLNCFILSGTNLRKYGKKGTWAVITGASDGLGKEFAEQLAAKGFNLVLISRTQSKLDDLARALTLRWTGFQAKTLAMDYSQDNDADYQRLAELISGLDVGILINNVGQSHSIPVPFLETARDELQNIVTINCLGTLKTTQVVAPKLVERKRGLILTMGSFAGVMPTPYLATYSGSKAFLQHWSSSLASELQPHGVDVHLVVSYLVTTAMSKIRRTSLLIPNPKQFVRSALGKVGLSSTEVFPNTYTPWWSHAVFKWVIENTVGSTSAFTIWYNRKMHVDIRKRALRKAEREAKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GWP1</accession>
    <name>A0AAJ0GWP1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rab-GTPase-TBC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_510787</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723301.1">
        <property type="nucleotide sequence ID" value="XM_062867879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GWP1"/>
    <dbReference type="GeneID" id="87886708"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.750:FF:000003">
        <property type="entry name" value="GTPase activating protein (Evi5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000027">
        <property type="entry name" value="GTPase activating protein (Evi5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000001">
        <property type="entry name" value="TBC1 domain family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23436">
        <property type="entry name" value="RabGap-TBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
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                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
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                <person name="Cros-Aarteil S."/>
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                <person name="Labutti K."/>
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                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
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                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 333.67</strain>
        </source>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Hiltunen Thoren M."/>
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        <source>
            <strain evidence="2">CBS 333.67</strain>
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    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
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                <person name="Martin F."/>
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                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
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                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
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        <location>
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        </location>
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        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="25954" checksum="5AD7E61A44D4FBDB" modified="2024-07-24" version="1">MQLSLLAFSLVAALPLVSAYPVKADTLNCRSGPGTSYKVIKTYKKGADLKITCQETGEVVQGSSLWDKTSDNCYVADYYVKTGTSGYVAPKCSSGGGSGGGEGTLPGLNKVQSSHARAIIAQAKKDGVGRHGCEAGIATALVETNIYVYANKNVPKSLNYPHDKVGSDHDSVGIFQQRVMYYPDIAADMDPAKSAGQFFKKMKGVSGWKTMAVGKLCQKVQVSAYPDRYAKRVAEATKICSAGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GXQ0</accession>
    <name>A0AAJ0GXQ0_9PEZI</name>
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        <submittedName>
            <fullName evidence="7">RF-1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_523418</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
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            <taxon>Chaetomiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723844.1">
        <property type="nucleotide sequence ID" value="XM_062868688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GXQ0"/>
    <dbReference type="GeneID" id="87887517"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000065">
        <property type="entry name" value="Peptidyl-tRNA hydrolase domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052405">
        <property type="entry name" value="Mito_Transl_Release_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46203:SF1">
        <property type="entry name" value="MITOCHONDRIAL TRANSLATION RELEASE FACTOR IN RESCUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46203">
        <property type="entry name" value="PROBABLE PEPTIDE CHAIN RELEASE FACTOR C12ORF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="6">
        <location>
            <begin position="49"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="36"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="130"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="130"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="168"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3308064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="198" mass="21697" checksum="6314A8E890A19C81" modified="2024-07-24" version="1">MLRFLPNARHLLHVAGPLQRCNGPLIIAPFTTTAPASLKQLPPRPKPPPESEIEESFLKGSGPGGQKINKTNSAVQLRHIPTGIVVKSQATRSRSQNRKIARELLAARLDELTNGTQSRTAIVAEVKKKRAASKAKKSRRKYRKLAEEQEKEGEEEEEGGEDEDELEEGSRSDEVEEKTKITGSINTTGTQVISQGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GXR8</accession>
    <name>A0AAJ0GXR8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_508583</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723849.1">
        <property type="nucleotide sequence ID" value="XM_062867733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GXR8"/>
    <dbReference type="GeneID" id="87886562"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3308069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="255" mass="27802" checksum="AD609CB3C877E537" modified="2024-07-24" version="1">MPAAGIAQDEIAQSALSAICDRFTTSSPDFYFLEASSVRIICPAPTEVGGSMKELADECNNQFCREASAECPPCGLQSRGIYTWRSRITPGDPETERRPLRPHDSSESEPFHLKRKIAEADPRTWDGDAEVRKPRRQGRLDDPASHDMAATREARKALLSFEVAKPGMGRTGVKNLHHAYLGPVPSVVYYITSDVGTGRGHVMVCSARSAALTEGSNVLHGAPHVDKIAPPVRNATTCRRHGQHVSLTMDLESVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GY15</accession>
    <name>A0AAJ0GY15_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallo-dependent phosphatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_508758</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724051.1">
        <property type="nucleotide sequence ID" value="XM_062867744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GY15"/>
    <dbReference type="GeneID" id="87886573"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07379">
        <property type="entry name" value="MPP_239FB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051693">
        <property type="entry name" value="UPF0046_metallophosphoest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905:SF16">
        <property type="entry name" value="SER_THR PROTEIN PHOSPHATASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G06000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="15"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3308271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="388" mass="42063" checksum="B3D21D57C53B1F7A" modified="2024-07-24" version="1">MPSSSGVLRPTRRTRIVCISDTHNSTIKLPKGDVLIHAGDLTNQGSYSEVRRAVQWLEKADFEAKIVIAGNHDITLDHDFYAKHGSNFHNNNPQDPARCLSLLTGSRTITYLQHSSATVRLTRPDGPCTEFKVFGSPYCPEYGTWAFMYKYPRPGLGAEASRSDDSPTAANPSAAELWAAIPPDTDILVTHTPAYTHCDDSFGCENLREALAKVRPRVHVCGHVHQGRGAERVRWDTDGLSVRNEVAAQVSVERWQDPAPDPSSAKISLVDLTGRGGKRPLDFHDRASLNGAQALYGTYDVPDPAQELSGSSPTDLAGRNDNTSALEPEARPGSTNTAGALDRAGRRETCVINWYVKSAMFVSLSGCLGGHCAPETGTFTSKAPPTTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GY90</accession>
    <name>A0AAJ0GY90_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type I 3-dehydroquinase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_91110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3307945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723725.1">
        <property type="nucleotide sequence ID" value="XM_062871442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GY90"/>
    <dbReference type="GeneID" id="87890271"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00502">
        <property type="entry name" value="DHQase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000135">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001381">
        <property type="entry name" value="DHquinase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050068">
        <property type="entry name" value="MurA_subfamily"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01093">
        <property type="entry name" value="aroD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43783">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43783:SF1">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01487">
        <property type="entry name" value="DHquinase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="525"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3307945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="761" mass="83028" checksum="17953FDE31E4F770" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GZ17</accession>
    <name>A0AAJ0GZ17_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Methylenetetrahydrofolate reductase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_118855</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methylenetetrahydrofolate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724576.1">
        <property type="nucleotide sequence ID" value="XM_062861599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GZ17"/>
    <dbReference type="GeneID" id="87880428"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004489">
        <property type="term" value="F:methylenetetrahydrofolate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00537">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.220:FF:000002">
        <property type="entry name" value="Methylenetetrahydrofolate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004621">
        <property type="entry name" value="Fadh2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053806">
        <property type="entry name" value="MTHFR_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00677">
        <property type="entry name" value="fadh2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754:SF1">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02219">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21895">
        <property type="entry name" value="MTHFR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MTHFR SAM-binding regulatory" evidence="10">
        <location>
            <begin position="431"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="359"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3308796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="696" mass="77253" checksum="A0FB7CA899F202FA" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GZI9</accession>
    <name>A0AAJ0GZI9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">U3 small nucleolar ribonucleoprotein protein IMP3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">U3 small nucleolar ribonucleoprotein protein imp3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0T15DRAFT_483523</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3309038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724818.1">
        <property type="nucleotide sequence ID" value="XM_062866167.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87884996"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="U3 small nucleolar ribonucleoprotein IMP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_uS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS4 N-terminal" evidence="12">
        <location>
            <begin position="4"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-binding S4" evidence="11">
        <location>
            <begin position="109"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00069727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3309038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="183" mass="21839" checksum="4D38EF1A161E663E" modified="2024-07-24" version="1">MTRKLKFHEQKLLKKHDFINYKQDNDHRHHDVARRYMIQKPEDYHKYNRLCGSLRQLAHRLSLLPPENEVRRKHETLLLDKLYDMGILSTKSKLSQVEHNVTVSAFARRRLPVVMTRLRMAETVQAATKLIEQGHVRVGVEEVRDPAFLVTRNMEDFVTWTHGSKIKQNILKYRDKLDDFELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GZY0</accession>
    <name>A0AAJ0GZY0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ca2+ regulator and membrane fusion protein Fig1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_483673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3309263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725043.1">
        <property type="nucleotide sequence ID" value="XM_062866178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GZY0"/>
    <dbReference type="GeneID" id="87885007"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000747">
        <property type="term" value="P:conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033481">
        <property type="entry name" value="Dni1/Fig1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28092">
        <property type="entry name" value="FACTOR-INDUCED GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28092:SF1">
        <property type="entry name" value="FACTOR-INDUCED GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12351">
        <property type="entry name" value="Fig1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3309263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="252" mass="27364" checksum="67B7AA18F0043284" modified="2024-07-24" version="1">MVFSQLKSYIPFRYIGFHHGLELLLVISIILLSILLVGCTTESMKDIYLLSLSYTGTEPTTTDTTIITANVSSCMTLAAASKTLLTVRVGYFGYCIVDNGVTSCSSDAGSLATLLRQTNSSDPLNMLYMVKSFHDQTIFSALPYLTRPGTASDSDSEREVKPFPWKAVSWLAWFMTLVATLFSLVAALWQHLSSAATATMVNTLTYGTVSGTVGAGAMAFAWIATGVLFIAVIGLLLMIMSMLAFELFYDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H056</accession>
    <name>A0AAJ0H056_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60S ribosomal protein L22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_525827</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724760.1">
        <property type="nucleotide sequence ID" value="XM_062868871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H056"/>
    <dbReference type="GeneID" id="87887700"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.210:FF:000001">
        <property type="entry name" value="60S ribosomal protein L22 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002671">
        <property type="entry name" value="Ribosomal_eL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038526">
        <property type="entry name" value="Ribosomal_eL22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064:SF31">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL22A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01776">
        <property type="entry name" value="Ribosomal_L22e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3308980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="126" mass="14237" checksum="B546B70B24A807EA" modified="2024-07-24" version="1">MAPIAKKSGAKKGPKVTKKFVINASQPASDKIFDVSAFEKFLNEKIKVEGRVGNLGETIKISQQGEGKIEIIAHNDLSGRYLKYLTKKFLKKMQLRDWLRVVSTSKGVYELKFFNVVNDEAEDDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H086</accession>
    <name>A0AAJ0H086_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein-tyrosine phosphatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_526010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3309040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724820.1">
        <property type="nucleotide sequence ID" value="XM_062868884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H086"/>
    <dbReference type="GeneID" id="87887713"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026893">
        <property type="entry name" value="Tyr/Ser_Pase_IphP-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13350">
        <property type="entry name" value="Y_phosphatase3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="1">
        <location>
            <begin position="155"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3309040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="286" mass="30594" checksum="91D7FCB7F563C2DF" modified="2024-07-24" version="1">MSDLDLLTLASTDVATPLPAHAVHAALSSPPFLLLPDTFNTRDLGLVPGSPIRPGLAYRSGGFLAGLSAEGKEALAGGKVTIRKVFDLRSVREHEARPDPDDIGGGKGLEVEVVWVRPDEEDALVGLEDFVEGGGEGGYVKMYMDVLKVYRGGIRAVLEHVRDGRGEEGFLFHCTAGRDRTGVMAGLLLSLAGASKETVALDYMLSRIGTEPAREQLLAFALKGSMAENTDAPGFHNLCNLRVSCWEAFVGAVESEYGGFEGYVTRTLGFSEQDLAKIKANLVLQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H0T0</accession>
    <name>A0AAJ0H0T0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_13286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725523.1">
        <property type="nucleotide sequence ID" value="XM_062861765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H0T0"/>
    <dbReference type="GeneID" id="87880594"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042520162" description="Secreted protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3309743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="119" mass="12665" checksum="B3C5568CB7098F88" modified="2024-07-24" version="1">MRPDSFCWLVGWPVCVLLFPQALLLCHGAICSSPGSMPALQLPALSVVSSMHPFPNAAWGGAEPNPISSMTPFRAPFLGCSAPGSHSTERWTQRSSALIGCRICIEPQLGISTGRGWAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H0Y3</accession>
    <name>A0AAJ0H0Y3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7721 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_515716</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725305.1">
        <property type="nucleotide sequence ID" value="XM_062868216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H0Y3"/>
    <dbReference type="GeneID" id="87887045"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056138">
        <property type="entry name" value="DUF7721"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39477:SF1">
        <property type="entry name" value="BETA-FLANKING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39477">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24845">
        <property type="entry name" value="DUF7721"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7721" evidence="2">
        <location>
            <begin position="50"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3309525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="220" mass="22433" checksum="42AC8EA9D094D5BD" modified="2024-07-24" version="1">MDKLIGKAVDKVFGDDDERRQEGLHQGGGNLTHGGAYPAGGGYPQHADADLRGAASVAAKDADDDEGFFSDVLGKLLQNKPPSQIADDDLDEEDAVQSHRKFFGLGGSEPAAHEQQASSSSLGSAAAMQALKLFTSGETGASSAQGSQSQSAFVGLAMAQAAKLFDAQASQGKVAPEADKQSVVMKAGEMALKMYLKSHGSQAGGSAGAGGLLSLASKFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H0Z6</accession>
    <name>A0AAJ0H0Z6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0T15DRAFT_3749</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725240.1">
        <property type="nucleotide sequence ID" value="XM_062864222.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87883051"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009584">
        <property type="term" value="P:detection of visible light"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000048">
        <property type="entry name" value="Sensor histidine kinase/response regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.270:FF:000002">
        <property type="entry name" value="Sensor histidine kinase/response regulator, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013654">
        <property type="entry name" value="PAS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016132">
        <property type="entry name" value="Phyto_chromo_attachment"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013515">
        <property type="entry name" value="Phytochrome_cen-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043150">
        <property type="entry name" value="Phytochrome_PHY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43065:SF10">
        <property type="entry name" value="PEROXIDE STRESS-ACTIVATED HISTIDINE KINASE MAK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43065">
        <property type="entry name" value="SENSOR HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08446">
        <property type="entry name" value="PAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00360">
        <property type="entry name" value="PHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50046">
        <property type="entry name" value="PHYTOCHROME_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0157">Chromophore</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 11" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="1" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Phytochrome chromophore attachment site" evidence="13">
        <location>
            <begin position="465"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="14">
        <location>
            <begin position="841"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="15">
        <location>
            <begin position="1325"/>
            <end position="1455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="98"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1078"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1297"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1482"/>
            <end position="1560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="130"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1124"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1156"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1179"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1208"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="1304"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1521"/>
            <end position="1560"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="11">
        <location>
            <position position="1376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50046"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3309460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1560" mass="171488" checksum="E9FD7F6903F35F71" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H1B3</accession>
    <name>A0AAJ0H1B3_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_570439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="249"/>
        </location>
    </feature>
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        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3309720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="249" mass="26895" checksum="08A3BDA66CE686AE" modified="2024-07-24" version="1">MYPASSVGSREDTFHDGSNVSPRVSRPTNPQRTEEARFPSPVQTRASSPAPEEHESPAGASTQGLSVKDALQRLVLNNCRITIIINQHAHTSPSGLDSDAFIETPHLLPRVPSPPLARNPTPGVSVPSHHDDFDSASLFCDDSSVDGDRDIDPGVDGGFAYMRQGRYGLEVDLPRGQGFWDRWDGRYRTEPVVRCPTPFGGVDVNPGEEGPQSDMWGGADVSTTVANDGYEDSDPTPERRATAGDQVDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ0H242_9PEZI</name>
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        <submittedName>
            <fullName evidence="4">CBF/Mak21 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_33798</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
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            <taxon>Sordariomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726112.1">
        <property type="nucleotide sequence ID" value="XM_062864132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H242"/>
    <dbReference type="GeneID" id="87882961"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040155">
        <property type="entry name" value="CEBPZ/Mak21-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12048">
        <property type="entry name" value="CCAAT-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12048:SF0">
        <property type="entry name" value="CCAAT_ENHANCER-BINDING PROTEIN ZETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCAAT-binding factor" evidence="3">
        <location>
            <begin position="592"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="138"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="520"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="692"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="874"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="902"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="693"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="704"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="874"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="907"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="939"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="950"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="960"/>
            <end position="971"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3310332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1020" mass="113252" checksum="C74BD1C7F93AA42C" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H2U6</accession>
    <name>A0AAJ0H2U6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_507411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726556.1">
        <property type="nucleotide sequence ID" value="XM_062867647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H2U6"/>
    <dbReference type="GeneID" id="87886476"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3310776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="223" mass="23342" checksum="DCEE795670CBF6A5" modified="2024-07-24" version="1">MPPQTSNATAASTGTAVPGKRFELPALEFKFGSLTDGTDIPPPLPSPVQEKKTAPATPDTPNARKPQQEGRDVTDRKPGNASPSSQLSGGSPAGSKRHAEDAPASPTLSSRPASIRRLLSRNNLMHQPHANGDGTEPDGRPQSRGNTSVADSRKAKRLSGWFGRLRGNESAASKPASPLSPTSPPVVEDKKPKGPPPPKIPELSKLGIQADSGFGSDLFKDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H374</accession>
    <name>A0AAJ0H374_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Hsp70-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_57604</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726751.1">
        <property type="nucleotide sequence ID" value="XM_062871010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H374"/>
    <dbReference type="GeneID" id="87889839"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF79">
        <property type="entry name" value="HSP70 FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G15200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="23"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="102"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="120"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="158"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3310971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="756" mass="82255" checksum="1892CC8C223A7914" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H3H0</accession>
    <name>A0AAJ0H3H0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable endonuclease LCL3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Probable endonuclease lcl3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B0T15DRAFT_388985</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LCL3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726919.1">
        <property type="nucleotide sequence ID" value="XM_062864469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H3H0"/>
    <dbReference type="GeneID" id="87883298"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.90:FF:000029">
        <property type="entry name" value="Probable endonuclease lcl3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302">
        <property type="entry name" value="EBNA2 BINDING PROTEIN P100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00318">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="Staphylococcal nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50830">
        <property type="entry name" value="TNASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="TNase-like" evidence="16">
        <location>
            <begin position="77"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK3311139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="275" mass="30837" checksum="C2CF65DF7F351B1E" modified="2024-07-24" version="1">MTGNDARRPSTPAPTKNEKSRLDTIANSIREHLSVPHNWIAPVIAAGLTLGLWTFYQSYLRRIPGTDHITPGFFRRRSLLGKVTSVGDGDGFHMFHTPGGRLAGWGWLRHVPKDRKELKGRTISVRIAGVDAPEGAHFGRPAQPYAAEALAFLESYVLHRRVRAYIYRRDQYERVVATVYVRRPPFFFPRKDVGLELLKHGLATTYEGKTGAEFGGPKLEAVYRVAEATAKSKGKGLWARAGPARSGKQQELESPMAYKKRMKMLEMPVEQKGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H419</accession>
    <name>A0AAJ0H419_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-(apurinic or apyrimidinic site) endonuclease 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0T15DRAFT_521505</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="11">Probably binds two magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727232.1">
        <property type="nucleotide sequence ID" value="XM_062868567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H419"/>
    <dbReference type="GeneID" id="87887396"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008311">
        <property type="term" value="F:double-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09088">
        <property type="entry name" value="Ape2-like_AP-endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000079">
        <property type="entry name" value="DNA-(apurinic or apyrimidinic site) lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020847">
        <property type="entry name" value="AP_endonuclease_F1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020848">
        <property type="entry name" value="AP_endonuclease_F1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010666">
        <property type="entry name" value="Znf_GRF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="AP ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748:SF4">
        <property type="entry name" value="DNA-(APURINIC OR APYRIMIDINIC SITE) ENDONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00726">
        <property type="entry name" value="AP_NUCLEASE_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00728">
        <property type="entry name" value="AP_NUCLEASE_F1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51999">
        <property type="entry name" value="ZF_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GRF-type" evidence="15">
        <location>
            <begin position="589"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="380"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="383"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="409"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="478"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="527"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="12">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="12">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA substrate" evidence="12">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3311452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="645" mass="71748" checksum="89CF6716F02FD3F5" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H4D9</accession>
    <name>A0AAJ0H4D9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_81535</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727412.1">
        <property type="nucleotide sequence ID" value="XM_062871350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H4D9"/>
    <dbReference type="GeneID" id="87890179"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05251">
        <property type="entry name" value="NmrA_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF31">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3311632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="313" mass="33515" checksum="33B6080D4EEA7E05" modified="2024-07-24" version="1">MTKLLTVFGATGVQGGSVIRAVLADSTLSKTFKIRAVTRDVSKPAAQALAQQGIEVTAADMGSRSSVDAAVQGTHTLFLVTLPDMMTGAPAGTETAQGKTVADAAKAAGVQHLIFSSLIDVTKASGGKLPHVHHFDSKARVEDYIRAQGIPATFLQPGYYMTNFTNLGLLRKGDDGSYTLAGPTGATKAQLPLIFTEDDMGKYFIAIAKQPLSKILNKTIPAAADYYTPQRIMDEFTAVTGHRGQYVQLDHGVYKGFLPPPIAQEILENELLCEHPGFFAGASLTDGHELLAEVGLKVTTWKEYLEARKGQFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H4G3</accession>
    <name>A0AAJ0H4G3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6604 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_482623</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727433.1">
        <property type="nucleotide sequence ID" value="XM_062866115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H4G3"/>
    <dbReference type="GeneID" id="87884944"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046539">
        <property type="entry name" value="DUF6604"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795:SF1">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20253">
        <property type="entry name" value="DUF6604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="438"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6604" evidence="3">
        <location>
            <begin position="7"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="571"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3311653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="708" mass="80477" checksum="AC88A502BC5E33BA" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H4I1</accession>
    <name>A0AAJ0H4I1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Mitochondrial outer membrane translocase complex, subunit Tom5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_490214</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="12 13 14" key="3">
        <citation type="journal article" date="2025" name="Proc. Natl. Acad. Sci. U.S.A." volume="122" first="e2507279122" last="e2507279122">
            <title>Structures of &amp;lt;i&amp;gt;Chaetomium thermophilum&amp;lt;/i&amp;gt; TOM complexes with bound preproteins.</title>
            <authorList>
                <person name="Agip A.A."/>
                <person name="Ornelas P."/>
                <person name="Yang T.J."/>
                <person name="Uboldi E."/>
                <person name="Hader S."/>
                <person name="McDowell M.A."/>
                <person name="Kuhlbrandt W."/>
            </authorList>
            <dbReference type="PubMed" id="40674418"/>
            <dbReference type="DOI" id="10.1073/pnas.2507279122"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS)</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Tom5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="method" value="EM"/>
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        <property type="resolution" value="3.80 A"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:mitochondrial outer membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:protein transmembrane transporter activity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Tom5"/>
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        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM5"/>
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    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
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            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00025716"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3311616.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        <name evidence="3" type="ORF">B0T15DRAFT_490321</name>
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        <name type="scientific">Chaetomium strumarium</name>
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            <taxon>Eukaryota</taxon>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
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                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
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        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727508.1">
        <property type="nucleotide sequence ID" value="XM_062866671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H4L3"/>
    <dbReference type="GeneID" id="87885500"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053018">
        <property type="entry name" value="Elsinochrome_Biosynth-Asso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37577">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37577:SF1">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
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        <location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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    </feature>
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    </feature>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3311728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="700" mass="77634" checksum="2E7220CCFBB31D5B" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LXQ9</accession>
    <name>A0AAJ0LXQ9_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_317244</name>
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    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717386.1">
        <property type="nucleotide sequence ID" value="XM_062864012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LXQ9"/>
    <dbReference type="GeneID" id="87882841"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="296"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3301606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="386" mass="39640" checksum="24ECC7200E8C780D" modified="2024-07-24" version="1">MAARRPPLPLDLLPQIVNEVIVTTGKAFKAAKRDGKANPAEVSVAINERIPAAVERFNSVLDDLEADILRAKSVLLRDLNQIRAQRNPPPPEPKPVAPPAPMSIDLTSPKLTAKPEPLTGLPGPTPPVNQANKPVAPFPNMGFDSASRQMAPTPSPKMAAKPRDVKGHGRPAGAVGGVAAGRASTAPLKKETKVPAPQVPRPGVAATAPQPTLNPSAPIKGSPTTVPSRPAPATTKTTINAPGPAARSSAPPAAGNEKLFTDMTFSPAPPPRDLPTPKQGTQPPANPPAQQPQPPGAGAANLGAGELPGLSMEPLARGPADVADMSSVDAKIDGLFSLGSGDMENLNHDYGFGSGDNSNFNDMYFATADSNGGAGDLDDTFFSLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LXU8</accession>
    <name>A0AAJ0LXU8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0T15DRAFT_405240</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717388.1">
        <property type="nucleotide sequence ID" value="XM_062865287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LXU8"/>
    <dbReference type="GeneID" id="87884116"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14212">
        <property type="entry name" value="PKc_YAK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000087">
        <property type="entry name" value="Dual specificity tyrosine-phosphorylation-regulated kinase 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000380">
        <property type="entry name" value="Serine/threonine-protein kinase ppk15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF17">
        <property type="entry name" value="HOMEODOMAIN INTERACTING PROTEIN KINASE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="334"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="185"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="678"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="730"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="791"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="844"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="149"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="680"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="732"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="851"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3301608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="898" mass="100348" checksum="5DF19DA3ED6D7EF4" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LXW6</accession>
    <name>A0AAJ0LXW6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_497400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717465.1">
        <property type="nucleotide sequence ID" value="XM_062867264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LXW6"/>
    <dbReference type="GeneID" id="87886093"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3301685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="207" mass="22066" checksum="B57FED9BE56E860C" modified="2024-07-24" version="1">MPVQPPNDDAYPSTKPNPMRNLSEYAVADTPGTCTPGPQRADYFRHDSLHCETAPAPLAAPATTFGPDTTQTSSKEGGKEGGVPSALGHGVVGGSGPTNERERKETRYVDVDVEGGDQTRRGAMEEQNDGVDADGKTAVYSEGQVADAVERGEITLDASEADLERKKQQQAAARKQVMDARKRGEDVDGRGTSMTSRRYPSANIEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LYB7</accession>
    <name>A0AAJ0LYB7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Emopamil-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0T15DRAFT_561933</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718001.1">
        <property type="nucleotide sequence ID" value="XM_062870562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LYB7"/>
    <dbReference type="GeneID" id="87889391"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000247">
        <property type="term" value="F:C-8 sterol isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047750">
        <property type="term" value="F:cholestenol delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004769">
        <property type="term" value="F:steroid Delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007905">
        <property type="entry name" value="EBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033118">
        <property type="entry name" value="EXPERA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14207:SF0">
        <property type="entry name" value="3-BETA-HYDROXYSTEROID-DELTA(8),DELTA(7)-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14207">
        <property type="entry name" value="STEROL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05241">
        <property type="entry name" value="EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51751">
        <property type="entry name" value="EXPERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="7" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="10" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="15">
        <location>
            <begin position="63"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3302221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="237" mass="26270" checksum="33531E929D99EDE4" modified="2024-07-24" version="1">MTAGAIFPSQGHPYFPQDAVIPGYVLNTTGLPLILSAFGAVVGVFVLGCIALSKQYNPTLRRADQLTVGWFALCGFLHCFFEGYFVLHHASVPSSQSLFAQLWKEYGLSDSRYLTSDPFMLCIETLTVLTWGPLSLATAVLTARSRPREQGTRHLLQAVVCVGHLYGVALYYGTCGFAEHMRGISYSRPEPVYYWGYYVGMNAPWVLVPCLLLWQSARAIQKAFAAVADLEERKKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LYV6</accession>
    <name>A0AAJ0LYV6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">tRNA pseudouridine synthase 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">tRNA pseudouridylate synthase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">tRNA-uridine isomerase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B0T15DRAFT_313750</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Formation of pseudouridine at positions 27 and 28 in the anticodon stem and loop of transfer RNAs; at positions 34 and 36 of intron-containing precursor tRNA(Ile) and at position 35 in the intron-containing tRNA(Tyr). Catalyzes pseudouridylation at position 44 in U2 snRNA. Also catalyzes pseudouridylation of mRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a uridine in tRNA = a pseudouridine in tRNA</text>
            <dbReference type="Rhea" id="RHEA:54572"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13934"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>uridine in snRNA = pseudouridine in snRNA</text>
            <dbReference type="Rhea" id="RHEA:51124"/>
            <dbReference type="Rhea" id="RHEA-COMP:12891"/>
            <dbReference type="Rhea" id="RHEA-COMP:12892"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718515.1">
        <property type="nucleotide sequence ID" value="XM_062863960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LYV6"/>
    <dbReference type="GeneID" id="87882789"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02568">
        <property type="entry name" value="PseudoU_synth_PUS1_PUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.580:FF:000002">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.660:FF:000002">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041708">
        <property type="entry name" value="PUS1/PUS2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00071">
        <property type="entry name" value="hisT_truA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF4">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase I TruA alpha/beta" evidence="17">
        <location>
            <begin position="400"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="305"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="354"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="14">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00036943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00053072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00073968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00079072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR641708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR641708-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK3302735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="606" mass="67747" checksum="732B03802D3C6800" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LYX2</accession>
    <name>A0AAJ0LYX2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Xaa-Pro aminopeptidase</fullName>
            <ecNumber evidence="5">3.4.11.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Aminoacylproline aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0T15DRAFT_487727</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.</text>
            <dbReference type="EC" id="3.4.11.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M24B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.9" evidence="5"/>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718498.1">
        <property type="nucleotide sequence ID" value="XM_062866457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LYX2"/>
    <dbReference type="GeneID" id="87885286"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01087">
        <property type="entry name" value="Prolidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000002">
        <property type="entry name" value="Xaa-Pro aminopeptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226:SF1">
        <property type="entry name" value="XAA-PRO DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase P N-terminal" evidence="12">
        <location>
            <begin position="11"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3302718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="460" mass="51473" checksum="B1D618F2BD2972D5" modified="2024-07-24" version="1">MDFDAILQGKYPARQHARRVVDYIRSKVPDATGVLYLESRMTKLLEDNDEPEPFRQRRFFYYLTGCELADSYVIHDMDSSKTTLFIPPINPESVIWSGLPVSAEEAMQKYDVDEVKYTTDVNAQLAHVAGQKAKSTVFAIPNQVSEHVTFLGFDNTNFSILKEAIEVCRVVKDEYELAMIAKANDISSKAHRVVMERAKHAKNERELEARFLADCISAGARNQAYHGIFAGGKAAATLHYVHNNAPLKGKLNLLVDAGAEWDCYASDITRTFPINGKFTKESRAIYDIVLKMQLECIAALKEDVLWDDVHLLAHKVAIDGLLELGILKGDKDEILANRTSVAFFPHGLGHYLGMDTHDTGGNPNYADEDTLFRYLRVRGRVPAGSVVTVEPGIYFCSFIIEPFLKDPKHAKYIDAEVLERYWDVGGVRIEDNVVVTKGGAENLTTAIKDPDHIEKIIASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZ55</accession>
    <name>A0AAJ0LZ55_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methylthioribose-1-phosphate isomerase</fullName>
            <shortName evidence="6">M1Pi</shortName>
            <shortName evidence="6">MTR-1-P isomerase</shortName>
            <ecNumber evidence="6">5.3.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">S-methyl-5-thioribose-1-phosphate isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MRI1</name>
        <name evidence="7" type="ORF">B0T15DRAFT_539074</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5-(methylsulfanyl)-alpha-D-ribose 1-phosphate = 5-(methylsulfanyl)-D-ribulose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19989"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="EC" id="5.3.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.23" evidence="6"/>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZ55"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046523">
        <property type="term" value="F:S-methyl-5-thioribose-1-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.420:FF:000003">
        <property type="entry name" value="Methylthioribose-1-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10470:FF:000003">
        <property type="entry name" value="Methylthioribose-1-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.420">
        <property type="entry name" value="translation initiation factor eif-2b, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01678">
        <property type="entry name" value="Salvage_MtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005251">
        <property type="entry name" value="IF-M1Pi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011559">
        <property type="entry name" value="Initiation_fac_2B_a/b/d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027363">
        <property type="entry name" value="M1Pi_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00524">
        <property type="entry name" value="eIF-2B_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004326">
        <property type="entry name" value="PRK05720.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00512">
        <property type="entry name" value="salvage_mtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475">
        <property type="entry name" value="METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475:SF1">
        <property type="entry name" value="METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 6" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3303092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="388" mass="42205" checksum="85B554AD10EC7976" modified="2024-07-24" version="1">MATLQAIKYERGRLLVLDQLRLPHENHYDEVSTAEEAFECIRSMRVRGAPAIAIVAALAHAVELHNGSCTATTPEETVAYIESRLDFLRESRPTAVDLSNAISLLKLAARAAKIEGLAHPEAKAAILNSYIEAAEKILEKDIENNKSIGRYGSLWLSQQFNARRDRPISVLTHCNTGSLATSGHGTALGIIRTLHSEGLLKHAYCTETRPYNQGSRLTSFELVFEGIPSTLITDSMAGALFALHRERMNIGAVIVGADRVVRNGDTANKIGTYALAVLARHHGVKFVVAAPTTSIDLETETGEGIKIEERKPEELTQITGAVVNADGSVDTSRTARVATADQRIGVWNPAFDVTPHALIDVIVTERGAVVKGADGKFNFSQVLPERWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZ62</accession>
    <name>A0AAJ0LZ62_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_262003</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718815.1">
        <property type="nucleotide sequence ID" value="XM_062863348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZ62"/>
    <dbReference type="GeneID" id="87882177"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF91">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G12070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042512671" description="FAD-binding PCMH-type domain-containing protein" evidence="4">
        <location>
            <begin position="25"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="172"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="547"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="547"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3303035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="665" mass="71897" checksum="07FA9DADC621777D" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZ86</accession>
    <name>A0AAJ0LZ86_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Rhamnogalacturonate lyase</fullName>
            <ecNumber evidence="11">4.2.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0T15DRAFT_263708</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Endotype eliminative cleavage of L-alpha-rhamnopyranosyl-(1-&gt;4)-alpha-D-galactopyranosyluronic acid bonds of rhamnogalacturonan I domains in ramified hairy regions of pectin leaving L-rhamnopyranose at the reducing end and 4-deoxy-4,5-unsaturated D-galactopyranosyluronic acid at the non-reducing end.</text>
            <dbReference type="EC" id="4.2.2.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the polysaccharide lyase 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.23" evidence="11"/>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718890.1">
        <property type="nucleotide sequence ID" value="XM_062863375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZ86"/>
    <dbReference type="GeneID" id="87882204"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102210">
        <property type="term" value="F:rhamnogalacturonan endolyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10317">
        <property type="entry name" value="RGL4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10316">
        <property type="entry name" value="RGL4_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10320">
        <property type="entry name" value="RGL4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000102">
        <property type="entry name" value="Rhamnogalacturonate lyase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1120:FF:000017">
        <property type="entry name" value="Rhamnogalacturonate lyase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.10:FF:000020">
        <property type="entry name" value="Rhamnogalacturonate lyase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1120">
        <property type="entry name" value="Carboxypeptidase-like, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029413">
        <property type="entry name" value="RG-lyase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029411">
        <property type="entry name" value="RG-lyase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016590">
        <property type="entry name" value="Rhamnogalacturonase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015364">
        <property type="entry name" value="RhgB_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36574">
        <property type="entry name" value="RHAMNOGALACTURONATE LYASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36574:SF1">
        <property type="entry name" value="RHAMNOGALACTURONATE LYASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14683">
        <property type="entry name" value="CBM-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14686">
        <property type="entry name" value="fn3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09284">
        <property type="entry name" value="RhgB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011794">
        <property type="entry name" value="Rhamnogalacturonase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 11 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042319232" description="Rhamnogalacturonate lyase" evidence="11">
        <location>
            <begin position="24"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase B N-terminal" evidence="13">
        <location>
            <begin position="25"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonan lyase" evidence="15">
        <location>
            <begin position="286"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonan lyase" evidence="14">
        <location>
            <begin position="372"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="53"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="191"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR011794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR011794-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF09284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF14683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF14686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3303110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="539" mass="57452" checksum="A4B3A463F0127D6B" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZK0</accession>
    <name>A0AAJ0LZK0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_401417</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719291.1">
        <property type="nucleotide sequence ID" value="XM_062865105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZK0"/>
    <dbReference type="GeneID" id="87883934"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13311">
        <property type="entry name" value="PH_Slm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046868">
        <property type="entry name" value="BAR_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046869">
        <property type="entry name" value="SLM1/RGC1-like_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043453">
        <property type="entry name" value="Slm1_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31941">
        <property type="entry name" value="CYTOSKELETAL SIGNALING PROTEIN SLM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31941:SF1">
        <property type="entry name" value="CYTOSKELETAL SIGNALING PROTEIN SLM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20400">
        <property type="entry name" value="BAR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20399">
        <property type="entry name" value="PH_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="300"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="274"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="437"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="450"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="492"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3303511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="504" mass="54381" checksum="C7A1F6B16725D555" modified="2024-07-24" version="1">MATHEPTAPSRQETLASIASDEAVPDTDPNTTAGLLAERLRAWKHAVVYLEEYMGAVEKIHKEQAKEYERVLKTISKPLREGEHFDQSLGGVAGFFENMRVNTQELINSNLETEKSIKGTALPIVERLHKEIKHKAKELVHGAEKAAKEVEKARNTTQKHIELLGQHTAAFEATGGKANPTDDPYVISRGVIHRLNKQVMEENNQHNDLVAVQTNFETFERHIVQVIHQAMETFNNFTGGQALKVQALHADMLGAVQRIPPDFEWKAFLKRSSDKLANPNEPPRTVESITFPNMDHPSTKPLIEGSLERKSRNKLSWGYSTGYYVVTPSKFLHEFKDDDNFRKDPTPELSIYLPDAIISVPSGEKFSVKGKDRSGGIGGKLAGTSELSFKAHSPAEAQKWFEVLKRAAGTTGPAAVVSATPTPGSEVANPIDAAAAAGEKPKPTVAVPAPQQQETGITGSETVASPVTVPGTPISVKAADGGGSGSSEKKGSVGSAGTGSAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZK7</accession>
    <name>A0AAJ0LZK7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_496050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719280.1">
        <property type="nucleotide sequence ID" value="XM_062867150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZK7"/>
    <dbReference type="GeneID" id="87885979"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="47"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3303500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="467" mass="51179" checksum="8158BDA7EAA0B669" modified="2024-07-24" version="1">MKLYVVSPDCAPNDQCLRINGAGWGLLEQDIADTQVLQLHPSEHADFICVSYSWGRGRCPSPFHPPFEVSDRTLPALTATIAQRPTCHRIWIDAFCVPPPSNPHLRAATLESMGFIYSRAAEVIVVVSSQALPVLQYITTTKDWVTRAWTYQEAVNARQLHFTTTTTISAAAAAGSGVLVDSMQLFSRLGHALALLAKTAPKERKRYPRLSAFEDVMCDRAVAAYLERSALQVMTVMEERTQTWPDDHFYAMMGAISTEPARASGAESACEAFMALCEQKGDWSFVFTSARRDGKIGGTRWRPTKEGGEGLKPIIKLPSWGGGLKGEWKDGCLVLEHIVVLGLGTAAHEVGAWIRWWLEGFDPRRYGSDAKLGPAAFEALRELGFSGSSEYLATENGLVFPQNPVPPSAQVEVLVTAEIRWSPGAPALVRYHGDTGTDPGLFFYEPAVFGEMPKLLAVHRPTAVSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZW5</accession>
    <name>A0AAJ0LZW5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pyruvate/Phosphoenolpyruvate kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_541435</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719637.1">
        <property type="nucleotide sequence ID" value="XM_062869858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZW5"/>
    <dbReference type="GeneID" id="87888687"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050251">
        <property type="entry name" value="HpcH-HpaI_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502">
        <property type="entry name" value="2-KETO-3-DEOXY-L-RHAMNONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502:SF8">
        <property type="entry name" value="SYNTHASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HpcH/HpaI aldolase/citrate lyase" evidence="3">
        <location>
            <begin position="58"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3303857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="316" mass="33869" checksum="2916A1263D5EF5CC" modified="2024-07-24" version="1">MTSRPFPEQPALHTVAQHRAGMLTYPGNLREALRQAQADPTKTLLGVAQGIPSVFVTKVLASTQPDFIWLDVEHAMFDRLTLFDAIQAAQHHSEGKSMVVVRVPKNDETALSTALDAGAAGIIIPHCESAQEVKDKIKEAFYPPLGERSFSPWTFTPGISDRSLYPNDAFNIQTSNRHICVIPQVESVKGIENIDEIAAVEGVSGLMFGPGDFSIDAGLELKLGGEPHPTFMAAMQKFVAAGKKYGKPLVGAAQVPQMIPMMIQQGYGAIAVVFDYWGLANMVHNGLKEAKGILDTAAASQSKTENGDAANGSAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M056</accession>
    <name>A0AAJ0M056_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphoesterase family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_230204</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAK3304099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062862935.1"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Probable acid phosphatase Pho610"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
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                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
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                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
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                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
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                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
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                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 333.67</strain>
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    </reference>
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                <person name="Cros-Aarteil S."/>
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062869525.1"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2790">
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    </dbReference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="409" mass="43701" checksum="0FAED4142FCA0A38" modified="2024-07-24" version="1">MAWDSKASRRRQSSAASGTKNIAIQARQQSRRVVQPQSPHVADPFLQHFLGPAFDPAAYLNAALPPLQTSSRVPGSQGATQPGAVPLAELSIQAQSVLSQLSAHTTRLTNTLTELTNDILRSGGRLAYEVELLRGETLGLAETLTERLEDDIAKFVPGGIRDNLAEPKAAADSHGSSSSHQRRMSILAPPAAATTAGASTPNEATTATSAAAQAPSPDEPASIAQLRTLTLVRSRLDSVIKTFGEAMEFVFPPSEVSVSSSFLSVSAPDAGGENHSTEEKGQQVLQALRDEISRLLNHPSDPIKGIEDAARRIEELKELATVWKGTAEEKGRTKFIESLARTVEDRHRELLREVEQSSNNRRDNTSRPPQLEAGAAGKAAADADAGQAETRSYGAYGLISQLQKLRNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
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                <person name="Kuo A."/>
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                <person name="Riley R."/>
                <person name="LaButti K."/>
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                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
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                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
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                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
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                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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            <end position="800"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="524"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="621"/>
            <end position="630"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
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                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
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                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
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                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
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        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        </alternativeName>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Chen C."/>
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                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
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                <person name="Ohm R.A."/>
                <person name="Martin F."/>
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                <person name="Lalanne C."/>
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                <person name="Ament-Velasquez S.L."/>
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                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
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    </reference>
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        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <person name="Kuo A."/>
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                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
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                <person name="Grigoriev I.V."/>
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                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
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    </reference>
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        <text evidence="7">Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation.</text>
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        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
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        <property type="entry name" value="OS-9-like"/>
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        <property type="entry name" value="OS9-like_dom"/>
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    <dbReference type="PANTHER" id="PTHR15414:SF0">
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        <property type="entry name" value="OS-9-RELATED"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
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        <location>
            <begin position="1"/>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3304802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="533" mass="58106" checksum="419B71268B43070E" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M0U1</accession>
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        <submittedName>
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            <taxon>Sordariomycetes</taxon>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
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        </source>
    </reference>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
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                <person name="Natvig D.O."/>
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                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
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                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
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        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
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                <person name="Kuo A."/>
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                <person name="LaButti K."/>
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    <reference evidence="2" key="2">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
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                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
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                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
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                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
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                <person name="Steindorff A."/>
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                <person name="Ament-Velasquez S.L."/>
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                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
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    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <begin position="21"/>
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        </location>
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        <source>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
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    <accession>A0AAJ0M2H8</accession>
    <name>A0AAJ0M2H8_9PEZI</name>
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        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
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    </protein>
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        <name type="scientific">Chaetomium strumarium</name>
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    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
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                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
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            <dbReference type="PubMed" id="37820761"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
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                <person name="Natvig D."/>
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                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
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                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
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        </subcellularLocation>
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    <comment type="similarity">
        <text evidence="3">Belongs to the WHI5/NRM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    <dbReference type="InterPro" id="IPR013734">
        <property type="entry name" value="TF_Nrm1/Whi5"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR28246:SF1">
        <property type="entry name" value="G1-SPECIFIC TRANSCRIPTIONAL REPRESSOR WHI5-RELATED"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
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        </location>
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    </feature>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
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            <end position="253"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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        </location>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3306334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="582" mass="60762" checksum="A175B3728F5B1902" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M2N6</accession>
    <name>A0AAJ0M2N6_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_509885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722294.1">
        <property type="nucleotide sequence ID" value="XM_062867824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M2N6"/>
    <dbReference type="GeneID" id="87886653"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF3">
        <property type="entry name" value="OXIDOREDUCTASE AN1597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3306514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="260" mass="30163" checksum="0E023BE6D05CB4AD" modified="2024-07-24" version="1">MATVTSSINYTAPLDLYKVEKPFYSNVPAPDGRQSNQVAWKYDAIEFHDIRADVSRFTLDENGFEIFRFGEESEEGVDKFDSDSWIEQSYYPVVESLLKARLGDVVVKVFDHTVRRRKTASDLLQIAGKYIRATRQPSFSAHCGFPFVQDQTLLSGENRIKFHMGPAAADLLKRRCRIINVWRPLFGPLEDCPLTYCDWRTVDIARDYKPADLIFPHYIGEQYLVTQHPDHRWHFLSGQRTNEFTLLKCWDNRTDVARSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M2S5</accession>
    <name>A0AAJ0M2S5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-2-hydroxyglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="7">1.1.99.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_566594</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2</text>
            <dbReference type="Rhea" id="RHEA:21252"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:16782"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="EC" id="1.1.99.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the L2HGDH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.2" evidence="7"/>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722741.1">
        <property type="nucleotide sequence ID" value="XM_062870700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M2S5"/>
    <dbReference type="GeneID" id="87889529"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047545">
        <property type="term" value="F:(S)-2-hydroxyglutarate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43104">
        <property type="entry name" value="L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43104:SF4">
        <property type="entry name" value="L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="9">
        <location>
            <begin position="29"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3306961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="403" mass="43714" checksum="CEC06C6E358574E7" modified="2024-07-24" version="1">MCQRYYYHAFSRPFSHTRPPAAKADFTHAVIGGGVVGLAIAQELAVRTGDSTLLLERHGAIGTETSSRNSEVIHAGIYYGPSSLKTELCIRGKDQLYSFCAAHGIPHRRTGKWIVAQNDAQLAALQQIHDFCTKEIHVPMRWVGPEEASRREPAVRAEKGILESPTTGIVDSHALMLCLLGRFEDAGGTLALSSAVEGITPLGSNGNEGWQLRVRDASTGEVSTVTAGSLINSAGLGAVAVHNMIVPPERRREMFYAKGNYFSYGASSPRVSTLIYPAPEPGHGGLGTHLTLDLAGRIKFGPDVEWVDSPDDLVVNQSRLAQTVREVKKYLPGLDETQLQPDYAGIRPKLGRQGAVALGKGFVDFVIQKEEGYQGWVNLLNIESPGLTSCLAIAERVRRLLYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M379</accession>
    <name>A0AAJ0M379_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Endo-chitosanase</fullName>
            <ecNumber evidence="10">3.2.1.132</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_393308</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Chitosanase catalyzing the endo-type cleavage of chitosan, the deacylated form of chitin. Chitosanase may be crucial in the degradation of the deacetylated portion of chitin in the fungal cell wall.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Endohydrolysis of beta-(1-&gt;4)-linkages between D-glucosamine residues in a partly acetylated chitosan.</text>
            <dbReference type="EC" id="3.2.1.132"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 75 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.132" evidence="10"/>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723132.1">
        <property type="nucleotide sequence ID" value="XM_062864680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M379"/>
    <dbReference type="GeneID" id="87883509"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016977">
        <property type="term" value="F:chitosanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009939">
        <property type="entry name" value="Chitosanase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42061">
        <property type="entry name" value="ENDO-CHITOSANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42061:SF6">
        <property type="entry name" value="ENDO-CHITOSANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07335">
        <property type="entry name" value="Glyco_hydro_75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 10 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042317347" description="Endo-chitosanase" evidence="10">
        <location>
            <begin position="32"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3307352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="268" mass="28262" checksum="1060B2B1C9AEFC61" modified="2024-07-24" version="1">MYGSSHLFALSSALLPSALLPALLDTAGVSAREVPANIQCLYDALRANGTCRHQLATGFFAKDDGPSTFFYCGDHLADFGYVYLKGPDSALADMDVDCDGVQHGPGDDGRCASSNDTQAETSFQGIVAGYNKGITDLNPFVHPYVVFGNRGSKPGWPTFDPREYGIEPHAVVPVVCNNQLHFAVWGDENGDDGDKPMIGEASISLATLCFGDSVNGNSGHDGADVLYMPFAGPDAVPGPDGADWAATTPQAFEASLEAIGTRLLQRIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M3X3</accession>
    <name>A0AAJ0M3X3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_97213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723867.1">
        <property type="nucleotide sequence ID" value="XM_062871502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M3X3"/>
    <dbReference type="GeneID" id="87890331"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3308087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="114" mass="12977" checksum="B7D4C322F76D88A5" modified="2024-07-24" version="1">MNMSVGFAMVIGTWPFCASHAHHMCALHARHVSLCFSPRHGDAGGVANGCQKPFRRQHRTRRKEPKRYTASFTFTIKRGFGEGRGDPETERKVKQRRRNGMRQTSPHLLGISCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M3Y7</accession>
    <name>A0AAJ0M3Y7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_490728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723912.1">
        <property type="nucleotide sequence ID" value="XM_062866707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M3Y7"/>
    <dbReference type="GeneID" id="87885536"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3308132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="506" mass="58081" checksum="F1F8BDDB599D8186" modified="2024-07-24" version="1">MDLDAPQSGQPMDPDDLGPMQTLSHGLKRTASNRDDNNEDSLMDGDAIMLEASAGAQPISPRITLRANSRAGQPPVVIDLTGSDNDDDLMIIDPPAAELSDKPYPKRLKLAQATWTQPTIQPQARHLVDFFTLPLEVRDKIYRLLLVSQGPIHVRQLWTERIRRPSRRHSKSDDLQTRIDTAILSVCRRTAAEGTRILYSENTFLYQLRDHAEQCWPRSEYRGQKDQATRKISLKKYGHLLRHMAIELEPNRTDEAYERLMAAALGTLTARPNNVRDNDHLLPDCGPIHLRTFTITISPLWETAKNGSRFLSVISFFSQGSDVLKQLQRIHVDFLRIVVHVNSHIKLYGINGRKIAQPDRHPSEMRYDLEMTLDLRCLSDPSHKKSDDEIGFLWQNDHLIREARQQQADKMAETLRNLRRHIEEACVRPDKAHLEGKLWENHTAAVQRRREERARLEARLNGDNLTVKDDDEEDGEEDEDWRIGGEKKILIISFVEIGGQKRAYRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M411</accession>
    <name>A0AAJ0M411_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carbohydrate-binding module family 48 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_523787</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 5'-AMP-activated protein kinase beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723987.1">
        <property type="nucleotide sequence ID" value="XM_062868723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M411"/>
    <dbReference type="GeneID" id="87887552"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000562">
        <property type="entry name" value="Snf1 kinase complex beta-subunit Gal83"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.250.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006828">
        <property type="entry name" value="ASC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037256">
        <property type="entry name" value="ASC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050827">
        <property type="entry name" value="CRP1_MDG1_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE , BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343:SF84">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04739">
        <property type="entry name" value="AMPKBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01010">
        <property type="entry name" value="AMPKBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160219">
        <property type="entry name" value="AMPKBI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Association with the SNF1 complex (ASC)" evidence="5">
        <location>
            <begin position="352"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="306"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="341"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3308207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="464" mass="49855" checksum="553DF85AA824C48A" modified="2024-07-24" version="1">MGNSPSTSKSTSQSSSQQAHSQHDRPVRRENKSPFPVQNHAVAAPPEPSLTQAQGTAVQPPSNTSSRSNPLQTRPFGPGGSSDFSAASSATTAASSTSSATPVDIKPGSLGTSHVPTKPVAVPNSHNLPSSPRSEDNCDSATMPYSSLQEVSYLTRPPRLPLPIEEEVHTPGSPIIAPTDVDQPVGDVEGLDATGLTHPVSNLSDNSVLEEDDTEELLVDKTRPTVPTRLEWRHGGDKVYLTGTIFQWNRKTRLHPVEGQPGVFATTINILPGTHHIRFLVDGQMQTSPDYPTTVDFGNNLVNYIEITPDDLPPTPAEADGVPESKSSQQQEQAHAAPTEEESKVPIAKDRDVPPANQFANKVPKYLLDLDQSEDSPLYQNAVLATERLPNPPGLPSFLSKPILNAATPRKDDNSVLTQPNHTVLNHLATSSIKNNVLAVSATTRYKSKYVTTIMYKPTTAEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M4A6</accession>
    <name>A0AAJ0M4A6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_109556</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724302.1">
        <property type="nucleotide sequence ID" value="XM_062861482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M4A6"/>
    <dbReference type="GeneID" id="87880311"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36427">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36427:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL1M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="289"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3308522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="302" mass="33100" checksum="AED915CF642FF2A3" modified="2024-07-24" version="1">MASLNQCLASLARLSLSTPARPILTPTIPKFLIPSATAPLVRHASGGGGMRKRPVKKKKTYKTYKTWDLSEIEQFSLCDALRYLRAFEVGRPPAVVKYELAVKLRTQKGGPVIRNRIRLPFPVKTDTRIGVICPEDSPLMIEAQQLGAVAVGQESLFESIRAGQLPFNKLICHVDSVEALRKANLGKILGPKGLMPSPKTKTITSDLKATVQELIGADEYRERDGVVRMAVGQLGFTPQMLSDNIKSFMNLLKQDISNSDDNHPKALDEVVLSSTNGPGFSLNGSFHPTDPKLKPEDLQSVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M4P2</accession>
    <name>A0AAJ0M4P2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CST complex subunit Ten1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_509375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724752.1">
        <property type="nucleotide sequence ID" value="XM_062867778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M4P2"/>
    <dbReference type="GeneID" id="87886607"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990879">
        <property type="term" value="C:CST complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043047">
        <property type="term" value="F:single-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016233">
        <property type="term" value="P:telomere capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024222">
        <property type="entry name" value="Ten1_fungal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12658">
        <property type="entry name" value="Ten1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3308972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="141" mass="15252" checksum="A0A33359D7E775A9" modified="2024-07-24" version="1">MFNGPRPSQLCLLSSLPSKQVGSKVRFLGCVRSYSPASGVLTLEHRLPEETCSVLAMVDVNLVLESLGPDQTRIGEWVNVIGYITDIPPLADGKEPNQQRSTVHAQAIVLWSAGPVDVRRYETSIKAFQPERATGSGSSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M4T0</accession>
    <name>A0AAJ0M4T0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_491567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3309033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724813.1">
        <property type="nucleotide sequence ID" value="XM_062866791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M4T0"/>
    <dbReference type="GeneID" id="87885620"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019034">
        <property type="entry name" value="UPF0390"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09495">
        <property type="entry name" value="DUF2462"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3309033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="98" mass="10297" checksum="729036126DCE1D4B" modified="2024-07-24" version="1">MVSAQMAQGAVKKTPKPALGGKGGKAAGKQQAKKSGISKPQAKKSKTTADKIQKKYTSGLVAKTEQMLGERAGHLELIGKGRKKGEEQKFKGGSRKFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M4W1</accession>
    <name>A0AAJ0M4W1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transcriptional Coactivator p15-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_491682</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transcriptional coactivator PC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3309151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724931.1">
        <property type="nucleotide sequence ID" value="XM_062866803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M4W1"/>
    <dbReference type="GeneID" id="87885632"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060261">
        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.31.10">
        <property type="entry name" value="Transcriptional Coactivator Pc4, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003173">
        <property type="entry name" value="PC4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009044">
        <property type="entry name" value="ssDNA-bd_transcriptional_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045125">
        <property type="entry name" value="Sub1/Tcp4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13215">
        <property type="entry name" value="RNA POLYMERASE II TRANSCRIPTIONAL COACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02229">
        <property type="entry name" value="PC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54447">
        <property type="entry name" value="ssDNA-binding transcriptional regulator domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcriptional coactivator p15 (PC4) C-terminal" evidence="8">
        <location>
            <begin position="45"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="107"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3309151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="161" mass="17955" checksum="D545D6FC96D42C79" modified="2024-07-24" version="1">MPFKKRRQIEADSDGEAQVTKKAKGDNKPKKDLSKGNDAEGNPYWEIGSNRRVGSSQFKGATLVNIREYYTTPDGELRPGKKGISLSLDQYKALLKVIPELNEELRSQGHAVDETQVSGTSDALVKAEKPTKSKKPKKPNFEQTSEEEEGDDEEEGKDEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M523</accession>
    <name>A0AAJ0M523_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SRR1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_515264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725126.1">
        <property type="nucleotide sequence ID" value="XM_062868174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M523"/>
    <dbReference type="GeneID" id="87887003"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012942">
        <property type="entry name" value="SRR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42080">
        <property type="entry name" value="SRR1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42080:SF3">
        <property type="entry name" value="SRR1-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07985">
        <property type="entry name" value="SRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRR1-like" evidence="1">
        <location>
            <begin position="201"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3309346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="377" mass="41985" checksum="B89F295C8A59987A" modified="2024-07-24" version="1">MSLRPQVDGDGDDDGVFIVVAYADLPDPPMTLDEKSERMTAAHRLIQAKYDAGILFFTKDSFRDVVRQFESDGNLDRLVSVTGLDGVAVHFPLEIGREYLTPMYEDDYVCIMTKPRLVYHPIERLLAAPGVSSYSVRRSCLPIEVAHSTEIRDARTNELVGLWPTSDYAAVKQRFERATRSLASSKEFVHLKSTLASVAIPPGIDKIVAFACSTMSWAGNDITRSMAQHALALAVRDFLANSDMTGADGEDVGGIKCYAQDPIYTPVDERVLSEAGFTVVDDPRAFLEVDEASVIIAMNPDIPVRQIIADLARPAIMIWNKVTVDDRNMAVTDPVSLRVERMVEEYIELPFPAEDEFFGRNLAIYIRRRGEKKNETG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M5H0</accession>
    <name>A0AAJ0M5H0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0T15DRAFT_515724</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SMC family. RAD50 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725307.1">
        <property type="nucleotide sequence ID" value="XM_062868217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M5H0"/>
    <dbReference type="GeneID" id="87887046"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003691">
        <property type="term" value="F:double-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051880">
        <property type="term" value="F:G-quadruplex DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043047">
        <property type="term" value="F:single-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000947">
        <property type="entry name" value="DNA repair protein RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867:SF12">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867">
        <property type="entry name" value="RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13558">
        <property type="entry name" value="SbcC_Walker_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="203"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="681"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="56"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="262"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="339"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="470"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="621"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="749"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="845"/>
            <end position="923"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3309527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1180" mass="136677" checksum="DD558B7EFCB78F73" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M5V6</accession>
    <name>A0AAJ0M5V6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_19015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725727.1">
        <property type="nucleotide sequence ID" value="XM_062862432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M5V6"/>
    <dbReference type="GeneID" id="87881261"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039328">
        <property type="entry name" value="WDR89"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22889">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22889:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3309947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="333" mass="35928" checksum="72395E6186BA572B" modified="2024-07-24" version="1">MYQLVNTDVFNYPRHDIFVLDILPVSTGFAATASDQTLSLFDPLRLSQGPVKRLRTDHGNLTAAKVYDAANSIICSTGENGTVSVWDLRLDPGRAQALQIGGNQSSLLSLACSNETNAIAAGTELADHQASIIIWDLRSPSIPRTQFNEVHSDDITELTYHPTNPSLLLSGSTDGLVNITDTSIADEDEAVQQTFNHGSVHRAGFLNETEVFAASHDEKFALYDMAEQTHTGAATVDFGDVRTLLGCQYLAAVAPKLGGMGAVVGVGTHDQDMFQLFHLAKGTGGWVLDRETVVGLPGAHESELVRSFCFYDEQQLVFTAGEDGCVKAWRPGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M6D3</accession>
    <name>A0AAJ0M6D3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_507406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726551.1">
        <property type="nucleotide sequence ID" value="XM_062867646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M6D3"/>
    <dbReference type="GeneID" id="87886475"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025638">
        <property type="entry name" value="DUF4336"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33835:SF1">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33835">
        <property type="entry name" value="YALI0C07656P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14234">
        <property type="entry name" value="DUF4336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042472481" description="Metallo-beta-lactamase domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3310771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="289" mass="31841" checksum="7F5974229FAE5C6D" modified="2024-07-24" version="1">MAGVVLLGAAVTLTLISRHKDSREEKKENARAMSSKLIPPNPDEVMVIRDITPNVVTFSVPFLRFGRFPIGGRGTLVRLRSGALAVFSPVALTEATKAKVASLGGDVRYLVATDIEHHIFLSEWAAVYPNAKLVGPEGLPEKRRKAAGSDPKVGDEPFAVAYVHAHPNKELVFLYKPDKVLIQADLMFNLPAVEQYSRVPDAEKPRLGMLGKMFGGMQSTEGEALGMKRFLWYAISRKDRTGFNESVRRIAGWDFETIVPCHGETIVGNGKELFEKVFAWHLEGKGARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M6N7</accession>
    <name>A0AAJ0M6N7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_571512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726851.1">
        <property type="nucleotide sequence ID" value="XM_062870862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M6N7"/>
    <dbReference type="GeneID" id="87889691"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3311071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="214" mass="24316" checksum="5DA62D510DAFD559" modified="2024-07-24" version="1">MDSRRRLEAELRNGAAFYEFIRSLTTNANNDLLTRLFDKATRLTQQRRGDASIATPLAYKQQLKRRLRLRAVWSRCPPRFFIMWFSLLRAARERRRNDPRSQQLLERETESRRRLRRAIDAFLDADTLDWSRPAPAGGPRYVLSSASNEVAPQGSSEMAVDGGSDEMAVDSGENGIRDDDNGAGESMNVDSLEQAMRDLDISGTEDASVDDRME</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M6U8</accession>
    <name>A0AAJ0M6U8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_58289</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726762.1">
        <property type="nucleotide sequence ID" value="XM_062871092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M6U8"/>
    <dbReference type="GeneID" id="87889921"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="293"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3310982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="751" mass="81718" checksum="41752B9E8940C75A" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M6V0</accession>
    <name>A0AAJ0M6V0_9PEZI</name>
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        <submittedName>
            <fullName evidence="13">FAD binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0T15DRAFT_426992</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062865661.1"/>
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    <dbReference type="GeneID" id="87884490"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:intracellular iron ion homeostasis"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF3">
        <property type="entry name" value="REDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
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    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
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        <location>
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            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="277"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
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    </feature>
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        <location>
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            <end position="481"/>
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    </feature>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
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        </location>
    </feature>
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        <location>
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            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3311089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="664" mass="73906" checksum="763B815571A9C4FC" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M7E1</accession>
    <name>A0AAJ0M7E1_9PEZI</name>
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        <submittedName>
            <fullName evidence="1">ATP synthase j chain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_490246</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727425.1">
        <property type="nucleotide sequence ID" value="XM_062866665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M7E1"/>
    <dbReference type="GeneID" id="87885494"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="ATP_synth_F0_jsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28060">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT J, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28060:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT J, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04911">
        <property type="entry name" value="ATP-synt_J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3311645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="62" mass="6568" checksum="315BC9C32D664B22" modified="2024-07-24" version="1">MSWLGVSLPKKFPTPVLRPMAPFLAAALIVGYGVNSAQNAMMNSAEFKNDPRNPNVKAGGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GKJ6</accession>
    <name>A0AAJ0GKJ6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_544105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717383.1">
        <property type="nucleotide sequence ID" value="XM_062870045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GKJ6"/>
    <dbReference type="GeneID" id="87888874"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="56"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3301603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="383" mass="41886" checksum="B24DD88A24B7BD20" modified="2024-07-24" version="1">MAHPQSAKVSEEILQDLSGTEYACSSLEPLSGGTANFLFKGILTRRLPDGTQEVAVKHGKAFVASMPDFQLSTARCRAEVECLKAFEELLVPPPLPPPQPTATDQTSPFTVRAPRLHHFSATTNTQVQEYLPNALSLKDYALKHFSASAAPAAAASRKPLCLELGRSLGGWLRDFHQRASSLLRDVVSANEPMQQLKHYVNYGTLVDTVANFPSILGDAKETFEKIREVTAQELQGPDLGVIHGDFWTGNALLSDEPLTEGAKTTVFIVDWEMCQLGVAPVDLGQMIAELYELSLFKGTDEGKWLIEGFAAGYGHVDDQFAFRTALHVGTHLVAWGSRVPGWGSEMQVQQVVGLGKEVILHAWHQDRAWFEAGDLACLFASTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GL02</accession>
    <name>A0AAJ0GL02_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_544775</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717610.1">
        <property type="nucleotide sequence ID" value="XM_062870103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GL02"/>
    <dbReference type="GeneID" id="87888932"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3301830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="516" mass="57986" checksum="51142EC4C1D0B672" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GL64</accession>
    <name>A0AAJ0GL64_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fatty acid hydroxylase superfamily-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_287658</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3301961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717741.1">
        <property type="nucleotide sequence ID" value="XM_062863662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GL64"/>
    <dbReference type="GeneID" id="87882491"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="7">
        <location>
            <begin position="202"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3301961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="375" mass="42471" checksum="7E3CB18D8C37F03D" modified="2024-07-24" version="1">MANITVASDLPPLPAYETRPMPDLLPFISDFWLLAILPHIAYWVVSLIFHVIDIYDLYPQYRLHTPEEITQRNLASRWEVLRDVIIEQVIQIITSAVLTLSEAQQTTGMEEYDVAVWATRIRLAQRTLPSVLGVLGLNAAAISKNMAATHPLLAGALAGGHYPFLTTTLDDVTGAAVPAFATWELLLAKAIYWVLIPCFQFWVAVAFLDTWQYFMHRAMHVNKWMYTHWHARHHRLYVPYAYGALYNHPVEGFVMDTLGAGAAYKVACMSPRMAMVFFTFSTMKTVDDHCGYKLPWDPLQHITSNNAAYHDIHHQSWGIKSNFSQPFFIIWDRLLGTMWTGDAKAKYERTRAAAAEKKKDVATGARTANGKAKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GLJ5</accession>
    <name>A0AAJ0GLJ5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_542166</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717954.1">
        <property type="nucleotide sequence ID" value="XM_062869912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GLJ5"/>
    <dbReference type="GeneID" id="87888741"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF5">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="46"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="313"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="462"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="318"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="359"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3302174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="584" mass="65528" checksum="E1DE502B23B06269" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GLT9</accession>
    <name>A0AAJ0GLT9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_505367</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718099.1">
        <property type="nucleotide sequence ID" value="XM_062867526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GLT9"/>
    <dbReference type="GeneID" id="87886355"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25391">
        <property type="entry name" value="WD40_Gbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GN-bd_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
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    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
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        <location>
            <begin position="67"/>
            <end position="108"/>
        </location>
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    <feature type="repeat" description="WD" evidence="5">
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            <begin position="156"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
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            <begin position="197"/>
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        </location>
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            <begin position="240"/>
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        </location>
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            <begin position="291"/>
            <end position="325"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3302319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="372" mass="40964" checksum="BC1CF050B8AA6ECA" modified="2024-07-24" version="1">MESGRPSDVSPEAMQARIQQARREAETLKDRIKRKKEELADTTLRAVASQAHEPIPKTQMMRTKRTLKGHLAKIYAMHWSTDRRHLVSASQDGKLIIWDAYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLNQNRDGPTRVARELSGHAGYLSCCRFINDRSILTSSGDMTCMKWDIETGSKVVEFADHLGDVMSISLNPTNQNTFISGACDAFAKLWDIRAGKAVQTFAGHESDINAIQFFPDGHSFVTGSDDATCRLFDIRADRELNFYGSESILCGITSVATSVSGRLLFAGYDDFECKVWDVTRGEKVGSLVGHENRVSCLGVSNDGISLCTGSWDAFVSPIVCHDNSWGLQLLTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ0GM65_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">B0T15DRAFT_308280</name>
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    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomium</taxon>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062863893.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87882722"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    </feature>
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            <begin position="208"/>
            <end position="218"/>
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    </feature>
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        <location>
            <begin position="422"/>
            <end position="444"/>
        </location>
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        <location>
            <begin position="497"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3302516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="538" mass="59974" checksum="E7AAB68EFC5C9224" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GMP7</accession>
    <name>A0AAJ0GMP7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">B0T15DRAFT_543975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718579.1">
        <property type="nucleotide sequence ID" value="XM_062870032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GMP7"/>
    <dbReference type="GeneID" id="87888861"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3302799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="488" mass="55930" checksum="C348E66FDF34DD7C" modified="2024-07-24" version="1">MKDLQPNCTGIPNFPPSRGALNARAIMSDLDLLPDVAIAEEARDNTVNGQAIYELIVQQPTRYAVMDDYNRLVRDTPIPGASLNGDTCVRSMLDKPQPAGDLVNADTVAKLYFDITEDRNISVTGILPTERPVSPETVRLLFTPLPRDLPAVDKDILILISAWSGDIDRYARLRRPVPVPGELQCVVRGIYHNTFFAKWWSTLPHVQHERLLGSEGRNLEHIHARLVMNNDLSWLTDSTPESELPRLIRHPHFANRVTYEELVRRRPSMKKTCVIACMHYNDKEAFTRFGEVIPDDDLLDAASDHDHHGWHCKWIETRAKELDIDLFPYMTDRQREEWQERRWKELWPMAMVHCKLWRSVYRTSMLYREITTGHLGFHNETPAMPGWKAAMNDCGRYAGIDMIELHVSALENVSRLVPEGYELRDLVVAYRDWEWVEERHIKMLGLYPDPAQPGGGAYRGRGRGRGGRVLPPFRRTSRSTMPSPGSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GNH6</accession>
    <name>A0AAJ0GNH6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NRDE protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_266245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062863408.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87882237"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="SER/THR-RICH PROTEIN T10 IN DGCR REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 2 HOMOLOG"/>
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    </dbReference>
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        <property type="entry name" value="TANGO2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3303186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="375" mass="41258" checksum="64A9B90C0B0CE6D1" modified="2024-07-24" version="1">MCIVLLTTAHPQYALVVLDNRDEYILRPTSRPHWWTAKPEHHTANGSAQGSNAVTSAKSDEVEVLSSRDLQRAERGTWLGITKGGNFAVLTNYRETDTRDAAHPVAGQRSRGGMVTAWLAADPAESTDQFVHRMLDDGGVKGVGGFSLICGKLRKARRGGNIEPLAIISNRCDHAGQVPWICGERDSLYGLSNATYLEPSEANRELLWPKIRDGLDLLNDAVASVGGESTEDEFVASLFKILDTENFPSDHTMELEDGIPLLKDSIFIPAFGGIEHQQEMSDAQQRGNVKQKSPNSDATETLTITARPDETPNGFQTGLYGTQRQTVILVDWDGNVRYTERALWDCNGNAIPRGEGDQTFGFKIEGWEQDAELCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GNV4</accession>
    <name>A0AAJ0GNV4_9PEZI</name>
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        <submittedName>
            <fullName evidence="3">DnaJ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_540173</name>
    </gene>
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        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719198.1">
        <property type="nucleotide sequence ID" value="XM_062869774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GNV4"/>
    <dbReference type="GeneID" id="87888603"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000110">
        <property type="entry name" value="DnaJ domain protein (AFU_orthologue AFUA_2G13210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
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    <dbReference type="InterPro" id="IPR056453">
        <property type="entry name" value="HTH_DNAJC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052594">
        <property type="entry name" value="J_domain-containing_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44144">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44144:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23302">
        <property type="entry name" value="HTH_DNAJC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="34"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3303418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + 4 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 4 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56008"/>
            <dbReference type="Rhea" id="RHEA-COMP:14356"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:139493"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) + 3 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 3 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56028"/>
            <dbReference type="Rhea" id="RHEA-COMP:14358"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60628"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="14"/>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719229.1">
        <property type="nucleotide sequence ID" value="XM_062863509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GNX6"/>
    <dbReference type="GeneID" id="87882338"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000047">
        <property type="entry name" value="Mannosyl-oligosaccharide alpha-1,2-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF101">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 14 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042573505" description="alpha-1,2-Mannosidase" evidence="15">
        <location>
            <begin position="23"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="373"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="417"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="509"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="330"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3303449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="529" mass="58576" checksum="B155CD3304200192" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GPC4</accession>
    <name>A0AAJ0GPC4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidase signature domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_540288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719240.1">
        <property type="nucleotide sequence ID" value="XM_062869778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GPC4"/>
    <dbReference type="GeneID" id="87888607"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678:SF34">
        <property type="entry name" value="OS04G0183300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="27"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3303460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="495" mass="52488" checksum="234C2D335FFBB070" modified="2024-07-24" version="1">MQLDVLTSTAADLRHLLEAGKTSSVQIVLAHLSQIERHEHKLHAFISVAPRELLLAIAADRDEERRRGRARGPLHGIPVVLKDSFITAGSELGIGTTAGSRALVGARASANSAIAQRLLDQGMIILGKTNMTEFAGMKMAGMTPGWSSAGGQTVSPYVGPIAEDETLLGHTNPGGSSTGSAVAVAAGFSPLAMGTETIGSIVTPAVRAGLYALKPTVGVQDVGGLFTLTDFFDSPGPMAKCAEDVLVMAEILLGRSFSRAGLGTWEGLAVGFLDPDVWKMAEETCRQHEGTAEQMKAEYEAVASKLEALGCAVKYPIHLVDASELTVDGMDAIMPIAFWEFKNICIPRFLSAFDQSPVRTLADIVAFNDAHKDNCLPSPYTNQDDLIKALNNTEAAAHIEVLKRGLRAAGRRILDQAFDNEAVDVIIAPGDCSLCIHAAAAGYPIAIAPLGQLRYNGRPFGLCMVAKENNEEVLLRFMAAYDSSGVGGRRPVPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQ40</accession>
    <name>A0AAJ0GQ40_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Up-regulated during septation-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_398771</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719827.1">
        <property type="nucleotide sequence ID" value="XM_062864968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQ40"/>
    <dbReference type="GeneID" id="87883797"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056703">
        <property type="entry name" value="DUF7801"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029191">
        <property type="entry name" value="Uds1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25078">
        <property type="entry name" value="DUF7801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15456">
        <property type="entry name" value="Uds1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Up-regulated during septation protein 1" evidence="3">
        <location>
            <begin position="86"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7801" evidence="4">
        <location>
            <begin position="808"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="346"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="602"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="661"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="755"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1034"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="497"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="864"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="610"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="762"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1042"/>
            <end position="1057"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3304047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1057" mass="117141" checksum="B7268D1D9F48D49C" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQ54</accession>
    <name>A0AAJ0GQ54_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Multicopper like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0T15DRAFT_512229</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Single-pass type I membrane protein</topology>
            <orientation evidence="7">Extracellular side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719806.1">
        <property type="nucleotide sequence ID" value="XM_062867963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQ54"/>
    <dbReference type="GeneID" id="87886792"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010106">
        <property type="term" value="P:cellular response to iron ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033215">
        <property type="term" value="P:reductive iron assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13851">
        <property type="entry name" value="CuRO_1_Fet3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13877">
        <property type="entry name" value="CuRO_2_Fet3p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13899">
        <property type="entry name" value="CuRO_3_Fet3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000022">
        <property type="entry name" value="FET5p Multicopper oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000024">
        <property type="entry name" value="FET5p Multicopper oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044130">
        <property type="entry name" value="CuRO_2_Fet3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF361">
        <property type="entry name" value="IRON TRANSPORT MULTICOPPER OXIDASE FET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="578"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="11">
        <location>
            <begin position="50"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="175"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="10">
        <location>
            <begin position="383"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3304026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="602" mass="65958" checksum="E67DA80FF2E7B09C" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQ57</accession>
    <name>A0AAJ0GQ57_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C2H2 type master regulator of conidiophore development brlA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_399372</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062865003.1"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP001273166">
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    <dbReference type="GO" id="GO:0000785">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:transcription regulator complex"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_sf"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF19">
        <property type="entry name" value="YY2 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <location>
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        <location>
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        </location>
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        <location>
            <position position="1"/>
        </location>
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        <source>
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        </source>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
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</entry>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
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                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
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            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3304403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    </protein>
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        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
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            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720136.1">
        <property type="nucleotide sequence ID" value="XM_062863039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQS4"/>
    <dbReference type="GeneID" id="87881868"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057646">
        <property type="entry name" value="WD40_WDHD1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022100">
        <property type="entry name" value="WDHD1/CFT4_beta-prop_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048591">
        <property type="entry name" value="WDHD1/CFT4_hel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19932">
        <property type="entry name" value="WD REPEAT AND HMG-BOX DNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19932:SF10">
        <property type="entry name" value="WD REPEAT AND HMG-BOX DNA-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20946">
        <property type="entry name" value="Ctf4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12341">
        <property type="entry name" value="Mcl1_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24817">
        <property type="entry name" value="WD40_WDHD1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDHD1 first WD40" evidence="9">
        <location>
            <begin position="12"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="230"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="WDHD1/CFT4 second beta-propeller" evidence="7">
        <location>
            <begin position="416"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="domain" description="WDHD1/CFT4 helical bundle" evidence="8">
        <location>
            <begin position="767"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="329"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="707"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="866"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="709"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="724"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="872"/>
            <end position="887"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3304356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="887" mass="98916" checksum="245C70E02B5008B4" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQY0</accession>
    <name>A0AAJ0GQY0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">O-acetylhomoserine aminocarboxypropyltransferase</fullName>
            <ecNumber evidence="12">2.5.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0T15DRAFT_536744</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-acetyl-L-homoserine + hydrogen sulfide = L-homocysteine + acetate</text>
            <dbReference type="Rhea" id="RHEA:27822"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57716"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="2.5.1.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-acetyl-L-homoserine + methanethiol = L-methionine + acetate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10048"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16007"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57716"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="EC" id="2.5.1.49"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homocysteine from O-acetyl-L-homoserine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.49" evidence="12"/>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720302.1">
        <property type="nucleotide sequence ID" value="XM_062869572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQY0"/>
    <dbReference type="GeneID" id="87888401"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003961">
        <property type="term" value="F:O-acetylhomoserine aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071269">
        <property type="term" value="P:L-homocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000083">
        <property type="entry name" value="O-acetylhomoserine sulfhydrylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000035">
        <property type="entry name" value="O-succinylhomoserine sulfhydrylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006235">
        <property type="entry name" value="OAc-hSer/O-AcSer_sulfhydrylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01326">
        <property type="entry name" value="OAH_OAS_sulfhy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43797">
        <property type="entry name" value="HOMOCYSTEINE/CYSTEINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43797:SF2">
        <property type="entry name" value="HOMOCYSTEINE_CYSTEINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="7 13 14" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="371"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="13">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00066529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3304522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="394" mass="42122" checksum="3B61F8A56B114C98" modified="2024-07-24" version="1">MNPTVDVFEKRIAALEGGVAAVAASSGQAAQFMAIAALAHAGDNIVSTSNLYGGTYNQFKVLFSRFGITTKFVNGDRAEDIAAAIDDKTKAVYIESIGNPRYNVPDFDAIVQVAHEKGVPVVVDNTFGAGGYFVRPIEHGADIVVHSATKWIGGHGTTIGGIIVDSGRFDWGKHAKRFPQMVEPSEGYHGLKFWETFGSITFAIRVRVELLRDLGACLNPFAAQQLLLGIETLSLRAERHAQNALALARYLEKSPHVSWVSYPGLESHQSHETAKKYLKRGFGGVLSFGVKGGGAAGSQIVDGFKLISNLANVGDSKTLAIHPWSTTHEQLTDEEKINSGVTEDLIRISVGTEHIDDIIADFEQSFKAAGTAKTEGGDKSAAEGAKAEEAPVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GR19</accession>
    <name>A0AAJ0GR19_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_495036</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720362.1">
        <property type="nucleotide sequence ID" value="XM_062867075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GR19"/>
    <dbReference type="GeneID" id="87885904"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043424">
        <property type="term" value="F:protein histidine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00088">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="entry name" value="HPT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045871">
        <property type="entry name" value="AHP1-5/YPD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28242">
        <property type="entry name" value="PHOSPHORELAY INTERMEDIATE PROTEIN YPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28242:SF52">
        <property type="entry name" value="PHOSPHORELAY INTERMEDIATE PROTEIN YPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="Histidine-containing phosphotransfer domain, HPT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HPt" evidence="2">
        <location>
            <begin position="58"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="1">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3304582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="167" mass="18619" checksum="AF4FB2236531A6F6" modified="2024-07-24" version="1">MAGDSTGVCDVEWQAIPAANRRSLSQDSQDMENTPDFGDHVDDQIFSQILEMDEDQSDRDFSAPLVFGFFEQAHETFEKMQDALSANDLSTLSGLGHFLKGSAATLGFNKIRDSCQVIQQYGHKLNVDGTSEPDEKVCLKKISEALETVEVDTKELEKIMNGFFKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GRF5</accession>
    <name>A0AAJ0GRF5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein BTN</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_252813</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Vacuole membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the battenin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720548.1">
        <property type="nucleotide sequence ID" value="XM_062863202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GRF5"/>
    <dbReference type="GeneID" id="87882031"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003492">
        <property type="entry name" value="Battenin_disease_Cln3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018460">
        <property type="entry name" value="Battenin_disease_Cln3_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981:SF0">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02487">
        <property type="entry name" value="CLN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015974">
        <property type="entry name" value="CLN3_BTN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01315">
        <property type="entry name" value="BATTENIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3304768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="471" mass="50581" checksum="5D5BF67F728560D0" modified="2024-07-24" version="1">MNRSPSASGLLPLPGAPSSSWALYRARIAAVFRNTEVSVLVAFWLFGLINNVLYVILLSAAQDLVGTSVPKGVVLLADVMPSFLTKLVAPYFIHRVPYSLRICVFVTLSSAGMLLVAFTPATTGSVSAKMLGVVLASLSSGGGELSFLGLTHYYGHLSLAAWGSGTGGAGLIGAGLYVVLTGWIGLGVKESLLVGAVLPGIMLVAFFGVLPRRRLEGWRGEYEPLREGDNVNGSVAAVGRERRERDEEEEDGFEDVPAGAASASLLAPGPSVAASAYGSGGGKGSFAANLRRARALFFPYMLPLLLVYVAEYTINQGVAPTLLFPLEQSPFSEFRAFYPFYGFLYQLGVFISRSSTPFVRIHHLYFPSLLQVANLMLLTLHALLNFIPSVYLVFVVVFWEGLLGGAVYVNTFAEIMEKVPAEDREFSLGATSVSDSGGICIAGFLGMAMEVWLCGWQVRHGRDYCRRIEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GRL7</accession>
    <name>A0AAJ0GRL7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP citrate synthase</fullName>
            <ecNumber evidence="2">2.3.3.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ATP-citrate (pro-S-)-lyase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Citrate cleavage enzyme subunit 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B0T15DRAFT_248641</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the formation of cytosolic acetyl-CoA, which is mainly used for the biosynthesis of fatty acids and sterols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>oxaloacetate + acetyl-CoA + ADP + phosphate = citrate + ATP + CoA</text>
            <dbReference type="Rhea" id="RHEA:21160"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.3.3.8"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Composed of two subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.8" evidence="2"/>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720400.1">
        <property type="nucleotide sequence ID" value="XM_062863142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GRL7"/>
    <dbReference type="GeneID" id="87881971"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003878">
        <property type="term" value="F:ATP citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06100">
        <property type="entry name" value="CCL_ACL-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000003">
        <property type="entry name" value="ATP-citrate synthase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.230.10:FF:000005">
        <property type="entry name" value="ATP-citrate synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000024">
        <property type="entry name" value="Probable ATP-citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23118">
        <property type="entry name" value="ATP-CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23118:SF42">
        <property type="entry name" value="ATP-CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01798">
        <property type="entry name" value="SCOASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA-binding" evidence="18">
        <location>
            <begin position="35"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00054002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00060724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00062455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00076189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00083544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAK3304620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="657" mass="71689" checksum="D52992653FC7D944" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GRV0</accession>
    <name>A0AAJ0GRV0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycoside hydrolase family 13 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_256012</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720712.1">
        <property type="nucleotide sequence ID" value="XM_062863247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GRV0"/>
    <dbReference type="GeneID" id="87882076"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033934">
        <property type="term" value="F:glucan 1,4-alpha-maltotriohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004574">
        <property type="term" value="F:oligo-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000025">
        <property type="term" value="P:maltose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11333">
        <property type="entry name" value="AmyAc_SI_OligoGlu_DGase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000064">
        <property type="entry name" value="Oligo-1,6-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.400.10:FF:000004">
        <property type="entry name" value="Oligo-1,6-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000087">
        <property type="entry name" value="Oligo-1,6-glucosidase IMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="entry name" value="Oligo-1,6-glucosidase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF179">
        <property type="entry name" value="NEUTRAL AND BASIC AMINO ACID TRANSPORT PROTEIN RBAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0462">Maltose metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="5">
        <location>
            <begin position="18"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3304932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="598" mass="68403" checksum="D9697B6C23C3F7EE" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GST5</accession>
    <name>A0AAJ0GST5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetrapyrrole biosynthesis, uroporphyrinogen III synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_574826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721283.1">
        <property type="nucleotide sequence ID" value="XM_062870970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GST5"/>
    <dbReference type="GeneID" id="87889799"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006780">
        <property type="term" value="P:uroporphyrinogen III biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06578">
        <property type="entry name" value="HemD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10090:FF:000011">
        <property type="entry name" value="Uroporphyrinogen-III synthase (UroS), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039793">
        <property type="entry name" value="UROS/Hem4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12390">
        <property type="entry name" value="UROPORPHYRINOGEN III SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12390:SF0">
        <property type="entry name" value="UROPORPHYRINOGEN-III SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="HemD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrapyrrole biosynthesis uroporphyrinogen III synthase" evidence="1">
        <location>
            <begin position="33"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3305503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="294" mass="32989" checksum="59DBD95C881D04A9" modified="2024-07-24" version="1">MTQKTPILLLKTKSVPGDSYEELFSTPSDGLVFEPSFVPVLEHRFDEQGMAKVRSFVQNRSISTAEDSAYGGLIFTSQRAVEAFTKLVEEKRGEVGWPHLQDVPVYSVGPATTRALKAVPQIPSLQVFGEHTGTGEKLAPFILEHYGEWYRDRKSKPPLLFLVGEKRRDIIPRILTEAEWQVDEVVVYGTGESKSFKDEFARRLEETAGHPRRWVVVFSPSGCDSMLSAMDMLDESTGKAKPKRPDRTTFVATIGPTTRDHLIHEFGYEPDVCAERPTPEGVWQGISRFVKGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GST7</accession>
    <name>A0AAJ0GST7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_502406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721055.1">
        <property type="nucleotide sequence ID" value="XM_062867435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GST7"/>
    <dbReference type="GeneID" id="87886264"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="245"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3305275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="486" mass="52841" checksum="36E1398ED423455C" modified="2024-07-24" version="1">MLLVSLPNRPYRYHQQQQHQQQPEPTTMSDTTTTTTTTTTPDTITPPSSPPPPNPRAATEGETTATATATTTITTTDPTRHDETHESAKRPKPRPGAILVRSRPSPTTTAAAAPDNFTSHDLTRWYEHKHIPEVLATGGVGFAVRYQLQASQQQEQEQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQLPRLSRAGTKRKRRRGTGGGGGGGGTGAGGKRKRAGLSGESASTTTSSRSGSGPGEGDAEEDSQSHTQDQSQTLGAETQLPFLAVYCLGDMGWLHDDGCPFWGVSLELDEEKPDGPLGLEKGDVPVDSAGGKGVRSVVEVAEFEAGFWEVVARVGFGEDERKGTPGPEGPAKHLVLVYLDAAQGDGNDPETVLRVSWPGLTAVGRVRSTLFRTDPTCPCPPAARALKGEGGIRPDEKKYLCMHEVWADGDNMAAILVANTLHYTLLSAFWGGEGGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GT76</accession>
    <name>A0AAJ0GT76_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fumarate reductase</fullName>
            <ecNumber evidence="4">1.3.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_485059</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Irreversibly catalyzes the reduction of fumarate to succinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>succinate + NAD(+) = fumarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18281"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.3.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="4">Binds 1 FAD per monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.6" evidence="4"/>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721225.1">
        <property type="nucleotide sequence ID" value="XM_062866272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GT76"/>
    <dbReference type="GeneID" id="87885101"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016156">
        <property type="term" value="F:fumarate reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050315">
        <property type="entry name" value="FAD-oxidoreductase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010960">
        <property type="entry name" value="Flavocytochrome_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01813">
        <property type="entry name" value="flavo_cyto_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400:SF12">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0274">FAD</keyword>
    <keyword evidence="1 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="5">
        <location>
            <begin position="9"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3305445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="489" mass="51218" checksum="1C05C9024B8D1A4A" modified="2024-07-24" version="1">MASPNPPPVIVVGAGLAGLSAAYSALQAGAPSVRLLERAAKPGGNSIKASSGISGAPTRFQNVAKYGVDHSFWDDTVKSAGTRLHASVAEPIRTQRQGLISLLTNRSASAIDFLTDLGVDLSVVAQLGGHSKPRTHRGAGKTPPGAAIVTTLLAKLKQAEPRFELVTEAEVTQLLTEDSRVAGVEYRKGGAVQALHGPVVFTTGGFGGDTHGLLAKYRPDLGGLPSTNDPRPGTHTLLSDVGAKLVDMESVQIHPTGFVDPANAQTPIKFLAAEVLRGEGGILLHKGKRIVNELETRERVSKVIMDLLPEGEGEGEGEGGDLRQWDVQLLLDPGATEAAAGHVGFYLWKGLVQKKKVRDLDVTTRETLREYAAVVRGDKKDAFGRIAFGHWNLGAEGADIDEDAEVCVGRVTPIVHFTMGGAVFNEQAQVLASELGEPQKPIPGLWAAGEITGGIHGDNRLGGSSLLECVVFGRIAGEQAAQSALKGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GT86</accession>
    <name>A0AAJ0GT86_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MEMO1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_415976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MEMO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721240.1">
        <property type="nucleotide sequence ID" value="XM_062865464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GT86"/>
    <dbReference type="GeneID" id="87884293"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07361">
        <property type="entry name" value="MEMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00055">
        <property type="entry name" value="MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002737">
        <property type="entry name" value="MEMO1_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04336">
        <property type="entry name" value="AmmeMemoSam_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060:SF0">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01875">
        <property type="entry name" value="Memo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3305460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="336" mass="37832" checksum="76639D20794F622E" modified="2024-07-24" version="1">MGTREASHAGSWYEDDPNELSSQLEKFLGHVPATLDGSDLPIPGARVIIAPHAGYTYSGPCAAWAYKSLDLRSAKRVFILGPSHTYYLRGCALTTFDKYETPFGDFVVDKATISELRQTGRFSNMPPRRDVDEHSLEMHIPYLWKRLEQTFGHDSSSYPSIVPILVGDGSEEEEKSFGKLLSRYLKDPETAWVVSSDFCHWGPRFSYRPVFREGVIRNLDAPRHKRDLQAPLDWNDVADNPESPEIHEVIKALDQMAMDAVEHGAHSRFYKVVQETQNTVCGRHPIGVTMAALEELQKEGLEEGKGKFKFVQYQRSSLVKEALDSSVSYASAYAII</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GTM4</accession>
    <name>A0AAJ0GTM4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_502973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721731.1">
        <property type="nucleotide sequence ID" value="XM_062867453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GTM4"/>
    <dbReference type="GeneID" id="87886282"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054208">
        <property type="entry name" value="DUF6914"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21858">
        <property type="entry name" value="DUF6914"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3305951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="217" mass="24052" checksum="1BB22F7572183F0A" modified="2024-07-24" version="1">MPSQFQPNSLYLSLNYLETDNGKHNYHWGLYVTGSTPPAGTLYHASNVDRRTRTIVPYRYENRPVTNDPTSSKSMVVSLLICPLPPTLVQYMDINIRPFEPLALKPKPRPPRGESDWNCRVWAKEILNLLQEKGVAMPADTNTIERQALLAANTNLRTHLGNAKVINDLSWLRAPAPRHAPPAPATAPAPAPTRAPAPARREGGGQKTTGDASKRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GTZ0</accession>
    <name>A0AAJ0GTZ0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_485572</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3306131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721911.1">
        <property type="nucleotide sequence ID" value="XM_062866297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GTZ0"/>
    <dbReference type="GeneID" id="87885126"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF73">
        <property type="entry name" value="TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="451"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3306131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="543" mass="60152" checksum="C96C1DFF76F7133A" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GUE6</accession>
    <name>A0AAJ0GUE6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_138227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722138.1">
        <property type="nucleotide sequence ID" value="XM_062861848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GUE6"/>
    <dbReference type="GeneID" id="87880677"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3306358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="207" mass="22723" checksum="628A45DD0B0D59C6" modified="2024-07-24" version="1">MCVGSCAVVYPQHLQLLVIENVGDPALDVLLAVFGSVFDIFMPCPQERCDHKHVTEISSLLMSLHHHLQYNDLAGTGMAEDTIFGSPSPGHVLRSESASPKISERSLKAAVVGIAVGSSVAGLLILALLIWTLLRIRRRRREVLEVRPAPWPNSPFPFVPPNLDKQLATQHVPIVVHEMPGSAVEPRHELPTPANSMTRFVAETPWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GV63</accession>
    <name>A0AAJ0GV63_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">G protein-coupled glucose receptor regulating Gpa2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_151012</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722506.1">
        <property type="nucleotide sequence ID" value="XM_062861993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GV63"/>
    <dbReference type="GeneID" id="87880822"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023041">
        <property type="entry name" value="Glucose_rcpt_Git3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022596">
        <property type="entry name" value="GPR1/2/3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF37">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR GPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11710">
        <property type="entry name" value="Git3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11970">
        <property type="entry name" value="GPR_Gpa2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="468"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="500"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose receptor Git3-like N-terminal" evidence="7">
        <location>
            <begin position="47"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="G protein-coupled receptor GPR1/2/3 C-terminal" evidence="8">
        <location>
            <begin position="456"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="259"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="619"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="294"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="323"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="382"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="619"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3306726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="644" mass="71784" checksum="7BE0645C61D65020" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GVA9</accession>
    <name>A0AAJ0GVA9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0T15DRAFT_393880</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722568.1">
        <property type="nucleotide sequence ID" value="XM_062864709.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87883538"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18604">
        <property type="entry name" value="ABC_6TM_VMR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001577">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF415">
        <property type="entry name" value="FI20190P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="805"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="900"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="972"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="999"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="95"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="519"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="900"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1174"/>
            <end position="1417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="187"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="259"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="754"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1401"/>
            <end position="1432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="214"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="264"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="278"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="764"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1403"/>
            <end position="1432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3306788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1432" mass="158955" checksum="8854B6C0771497D9" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GVC3</accession>
    <name>A0AAJ0GVC3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SMODS and SLOG-associating 2TM effector domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_510158</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722596.1">
        <property type="nucleotide sequence ID" value="XM_062867842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GVC3"/>
    <dbReference type="GeneID" id="87886671"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041622">
        <property type="entry name" value="SLATT_fungi"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033635">
        <property type="entry name" value="SLATT_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38793">
        <property type="entry name" value="SLATT_FUNGAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38793:SF3">
        <property type="entry name" value="SMODS AND SLOG-ASSOCIATING 2TM EFFECTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18142">
        <property type="entry name" value="SLATT_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="SMODS and SLOG-associating 2TM effector" evidence="3">
        <location>
            <begin position="165"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="308"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3306816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="329" mass="34726" checksum="C2CF79B104BBFF39" modified="2024-07-24" version="1">MPASPDSKVQPLPPQVHTTVTEVPPAVAPEPTTNTTTTTTTHLKPTAAILDHAYDRDFKQPNPNPPSNNPSQSDVGLGSLGVVGVGVGAGGGGSVLPRADTELSWGAPAGLHIRGLNDENLVIFRRAVGINSTLVAGPGPGSSSTDPASLEEGRRRAEGIYAAALSAVRRKTWSYHFLSWLINACHFVQIIIGASLTALGPSAGSHVVVITLLGAINTVIAGVLALIKGQGLPDRLYHDRAEYRRLQDWIEQTEALLAVGIIGRDRKEVGVLVQTAFKKYNAAMQCVESNLPENYTHPPESEQLSVAGSRKGSPSPSGHHGRSPGPYHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GVK2</accession>
    <name>A0AAJ0GVK2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NUDIX hydrolase domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_484051</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722570.1">
        <property type="nucleotide sequence ID" value="XM_062866201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GVK2"/>
    <dbReference type="GeneID" id="87885030"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43046">
        <property type="entry name" value="GDP-MANNOSE MANNOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43046:SF14">
        <property type="entry name" value="MUTT_NUDIX FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="24"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3306790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="186" mass="20546" checksum="3849F02B993E72D5" modified="2024-07-24" version="1">MMTATSSFPDPKVIGTKKPGVSYTDRHSARVVAFNAGGEVAILYAKRENYYKLPGGGIEPGEDHETAAKREFQEETGGLIRLRGNGCVAATEEFRFQQRQVSYCYCADLVDDSGEPALIEEEREDGLGHLWMSVDEAKKAMAAAEPSSEFGRSVKERDMYLLDQASKYIAIQLPFTRGNPDDQQAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GVL2</accession>
    <name>A0AAJ0GVL2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Solute carrier family 40 member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_394240</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in iron transport and iron homeostasis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722766.1">
        <property type="nucleotide sequence ID" value="XM_062864720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GVL2"/>
    <dbReference type="GeneID" id="87883549"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005381">
        <property type="term" value="F:iron ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17480">
        <property type="entry name" value="MFS_SLC40A1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009716">
        <property type="entry name" value="Ferroportin-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11660">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 40 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11660:SF57">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 40 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06963">
        <property type="entry name" value="FPN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3306986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="479" mass="52107" checksum="28F894864ABDCEF7" modified="2024-07-24" version="1">MTVEAGGVGSRQHAGRYRDTVPRSLEVRLYTSHFLSTWNSRLFEFAAVLFLASIFPDTLLPMSVYALARSGAAIVLARPVGRLIDKGDRLAVVRASIIGQRLAVAASCALFWALERRGRRMAARLGDGLFALAVILACVEKLCSLMNLVAVERDWAAVITEGDELARRVLNARVRRIDLVCKLLGPLAISTIAISSTLVAIIATLAMNLVSVLVEYICIAQVYKQVPSLARGPAASDNELPPSTRPSTGAWLRPSISHVLPVSSLPFYFRHAAFLPSFSLTLLYLTVLSFSGQMITYLLSVGYNSLHVGIARTVSTVFELSATWIAPRLMERIGVVRGGIWSLCWQMVWLAAGISWFFADFSGMGTNSAISATGLAVGVALSRVGLWGYDLCAQNIVQDEVEAELRGTFSTAEASFQNLFELLSYVATIVFSRPDQFQWPVVISVIAVYAAGGLYASFVRRRRGHLFHPPPCGCKQGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GWZ2</accession>
    <name>A0AAJ0GWZ2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_530788</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723451.1">
        <property type="nucleotide sequence ID" value="XM_062869195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GWZ2"/>
    <dbReference type="GeneID" id="87888024"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3307671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="98" mass="11578" checksum="66D917133222D541" modified="2024-07-24" version="1">MTVPRQSRFSETGQGRVNALLQAYTASAIEEEGNKKPFVALGTKAERDRIWDTWTEILRDVPWQLYLTPSIPEGDVFYKQLARWKAFRNWQKYNRDIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GWZ7</accession>
    <name>A0AAJ0GWZ7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inositolphosphorylceramide synthase subunit Kei1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_510937</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723471.1">
        <property type="nucleotide sequence ID" value="XM_062867884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GWZ7"/>
    <dbReference type="GeneID" id="87886713"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070916">
        <property type="term" value="C:inositol phosphoceramide synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070917">
        <property type="term" value="F:inositol phosphoceramide synthase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006673">
        <property type="term" value="P:inositol phosphoceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013862">
        <property type="entry name" value="Kei1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28077">
        <property type="entry name" value="INOSITOL PHOSPHORYLCERAMIDE SYNTHASE REGULATORY SUBUNIT KEI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28077:SF1">
        <property type="entry name" value="INOSITOL PHOSPHORYLCERAMIDE SYNTHASE REGULATORY SUBUNIT KEI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08552">
        <property type="entry name" value="Kei1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="285"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3307691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="384" mass="42110" checksum="2F87488CF3AD1684" modified="2024-07-24" version="1">MDALYFTVLDAMSVWCTVTMHSLYFVHFCGKYYRRRDRLLREGVGAVIESRRMPSAREEAHRMQPMPSAKSAKTETLGQLADASDASTYTVSSKHVVANAGSHHWRERPKHTIRNALRSGNDIGPEFNMPSIPKTSWLRVPRPRSFLGLLSLQTGTELISVALVFNKATGVYGLLTLFTGYSLSALQVTAYLGSILVLVALALCVPHIRKQSPLQNLALAWVYAIDTVVSAAYTTAFATSWYLALRNDPTGPAGHEEAPGTQSANGQVRRDGGQAKAAAGVEDTAASMVLIVAFSLVRVYFSLVVMAYARMVLLRFVDERMADAEDVSGTTADPFAVGAPLGEGWRGQLGRAMVSVGRGYWLGGKKEDEEWARRVKAKFRSTRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GX48</accession>
    <name>A0AAJ0GX48_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Microbial-type PARG catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_493173</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723487.1">
        <property type="nucleotide sequence ID" value="XM_062866925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GX48"/>
    <dbReference type="GeneID" id="87885754"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012664">
        <property type="entry name" value="CHP02452"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019261">
        <property type="entry name" value="PARG_cat_microbial"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02452">
        <property type="entry name" value="TIGR02452 family protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35596">
        <property type="entry name" value="DUF2263 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35596:SF1">
        <property type="entry name" value="MICROBIAL-TYPE PARG CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10021">
        <property type="entry name" value="PARG_cat_microb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Microbial-type PARG catalytic" evidence="2">
        <location>
            <begin position="119"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3307707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="386" mass="42051" checksum="37C4DF7AAD8E38CD" modified="2024-07-24" version="1">MWRKKYYENPRRLALAAIAKETQERTPTIAARLPHLDVSKSEKLDLPSLPPLDPAKCPQFRIPNQGSLVGTTTRVFNRDSFDAALSMSSSILDLHPTPGEKSITSTENEKEILSHLEPLSASPTNLNPSTAARVAVLNMASDRNPGGGWLNGASAQEEALCFRSTLAASLHRAYYPLRRREGLYTPDVVVFRRSAAAGGEEGHKLMVPETAVGELPVVSVLSVAGIRGPEVRPEGEEGGREEGGQEKKAVGKEAAESGRKEAEGDQERGKGKTKTPKGPFVFADPAARELTKDKMRLCLRMAGAKGHTMLVLGALGCGAFRNPPQEVARCWQEVLGEAEFAGGWFREIWFAVYDRRNEGNFDVFRDAFDGKVVGERKLSGLGEVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GXC9</accession>
    <name>A0AAJ0GXC9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_428463</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alkylbase DNA glycosidase AlkA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3307918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723698.1">
        <property type="nucleotide sequence ID" value="XM_062865688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GXC9"/>
    <dbReference type="GeneID" id="87884517"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032993">
        <property type="term" value="C:protein-DNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032131">
        <property type="term" value="F:alkylated DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008725">
        <property type="term" value="F:DNA-3-methyladenine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043916">
        <property type="term" value="F:DNA-7-methylguanine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000004">
        <property type="entry name" value="DNA-3-methyladenine glycosylase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051912">
        <property type="entry name" value="Alkylbase_DNA_Glycosylase/TA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43003">
        <property type="entry name" value="DNA-3-METHYLADENINE GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43003:SF5">
        <property type="entry name" value="DNA-3-METHYLADENINE GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="5">
        <location>
            <begin position="194"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3307918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="372" mass="40829" checksum="B5CD3649BF9CB5F4" modified="2024-07-24" version="1">MASRRSARLAALISNNGSITDPAPPPPPPVASRKRKAATQASATVEESGRKVPSTPRRRRTAKQDAGEPPTPTPNPVSLIAEEAHSRKPRPAAITRLADPSRTNALLRSPKTSRIISSTPVDAVPSKLREMIKPTAGTTTTTTTANILEEACAHLIKVDPRMKPLIDKHHCRIFSPEGLAEQIDPFESLCSSIISQQVSGAAAKSIKARFIALFNSKDNSNTIFPRPDQVAATPLETLRTAGLSQRKAEYVKGLAEKFASGELTAQMLADAPYEEILEKLTAVRGLGKWSVEMFACFALKRMDVFSTGDLGVQRGMAAFVGRDVAKLKAKGGKWKYISEKEMEEISERFRPFRSVFMWYMWRVEETDISTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GXF7</accession>
    <name>A0AAJ0GXF7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_493116</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723430.1">
        <property type="nucleotide sequence ID" value="XM_062866920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GXF7"/>
    <dbReference type="GeneID" id="87885749"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="191"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="11"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="193"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="228"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="258"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3307650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="268" mass="30453" checksum="2B03DC4A93816321" modified="2024-07-24" version="1">MEHSNTTLCVVQKTEARLREAEAMCARLAAEKENLQASLRAMSVELDVTRRQCERVKAERKNLRSHVKAIKSLRVDLATAKRECEILKKERDELRGQVQALGKTPIQLAAAREECEYTKVERNRLQHRLDVVEADLANLEKKHIFACNELAAMQGGRLNFQVQLHMPREPLPNVQSTASDFEKPPLFARSLGEDTQSTSDHATPSREWQATPGRTAETKTPNNILVPIKEEPGQERRGVKEGMQLYRPPRAGRKDALEDMEPGEIWED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GXG0</accession>
    <name>A0AAJ0GXG0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cell wall biogenesis protein Mhp1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_90684</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3307929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723709.1">
        <property type="nucleotide sequence ID" value="XM_062871437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GXG0"/>
    <dbReference type="GeneID" id="87890266"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052410">
        <property type="entry name" value="DRC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24107:SF2">
        <property type="entry name" value="NLR FAMILY CARD DOMAIN CONTAINING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24107">
        <property type="entry name" value="YNEIN REGULATORY COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="227"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="981"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1178"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="231"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="249"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="291"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="318"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="371"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="981"/>
            <end position="998"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3307929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1199" mass="129215" checksum="D27654A51F777298" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GXJ2</accession>
    <name>A0AAJ0GXJ2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0T15DRAFT_523098</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">The twin Cx2C motifs are involved in the recognition by the mitochondrial MIA40-ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the anamorsin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3307947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723727.1">
        <property type="nucleotide sequence ID" value="XM_062868667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GXJ2"/>
    <dbReference type="GeneID" id="87887496"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03115">
        <property type="entry name" value="Anamorsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007785">
        <property type="entry name" value="Anamorsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046408">
        <property type="entry name" value="CIAPIN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031838">
        <property type="entry name" value="Dre2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13273">
        <property type="entry name" value="ANAMORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13273:SF14">
        <property type="entry name" value="ANAMORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05093">
        <property type="entry name" value="CIAPIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16803">
        <property type="entry name" value="DRE2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0408">Iron</keyword>
    <keyword evidence="8 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-S cluster assembly protein Dre2 N-terminal" evidence="13">
        <location>
            <begin position="45"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Anamorsin C-terminal" evidence="12">
        <location>
            <begin position="260"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Fe-S binding site A" evidence="10">
        <location>
            <begin position="265"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Fe-S binding site B" evidence="10">
        <location>
            <begin position="326"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cx2C motif 1" evidence="10">
        <location>
            <begin position="326"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cx2C motif 2" evidence="10">
        <location>
            <begin position="337"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="16"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3307947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="363" mass="38254" checksum="4FF94FC23F535558" modified="2024-07-24" version="1">MSPSLEMDLTPDFDPANRAGAGAGAPPSTKTATTNDTSSSSSSSSRTLLLAPPSLASRQDRIGALFATHPRATTDLQMLDRLAAGLVTLPAATYDLVLVLTDPDGSRRAEAFALLRDRAVWARLVPALKAGGTLRSEDGSLAPGPDAGAEAREAVLAGLVAAGGDGVDGFTKPEYEEEVVVPLRFGLSKTNGKSTNGGEEATQKQNGTNGEAKAAAPAGVGFVDFSDELDLDVDLDAEDDDDVIDEDTLLTEEDLRRPIQQPPECQPQPGKKRRACKDCTCGLAARMEAEDKARRAKADKELNTLKLKSEDLNELDFTVPGKTGSCGSCYLGDAFRCSDCPYIGLPAFKPGEEVKILNNTVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GYI9</accession>
    <name>A0AAJ0GYI9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conidiation protein 6-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_108308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724237.1">
        <property type="nucleotide sequence ID" value="XM_062861460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GYI9"/>
    <dbReference type="GeneID" id="87880289"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018824">
        <property type="entry name" value="Conidiation-specific_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052670">
        <property type="entry name" value="UPF0654_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36576:SF2">
        <property type="entry name" value="PROTEIN CON-6, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03615)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36576">
        <property type="entry name" value="UPF0654 PROTEIN C11D3.01C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10346">
        <property type="entry name" value="Con-6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3308457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="143" mass="15708" checksum="F56B1DC5E31BE96E" modified="2024-07-24" version="1">MSDKNRERGLKAAIHNPRVSEEAKQHDRELLASEFGEQVEEPEQTGKSKRRSSTSRSAAPRLHQTKRETQPGSSTAAPEAHASGTKARRASSGDTGGSQQIGEEKDRGNVIRGLKAALKNPHVSEKAKEEDRKRLQEMGETVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GYM0</accession>
    <name>A0AAJ0GYM0_9PEZI</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">B0T15DRAFT_524594</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724294.1">
        <property type="nucleotide sequence ID" value="XM_062868780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GYM0"/>
    <dbReference type="GeneID" id="87887609"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042527273" evidence="2">
        <location>
            <begin position="22"/>
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        </location>
    </feature>
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        <location>
            <begin position="368"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="476"/>
        </location>
    </feature>
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            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="466"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3308514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="505" mass="52486" checksum="A85730B22654E678" modified="2024-07-24" version="1">MLSTLPTIAATLGLLTQAVNGWREKPQHAHSSVSIDCDSSAIHDFVTVYNTTTVEITHWVAVTVNTTHINTVTVDVTQTALATVTATDTDSVTITNSTTITNTATDSVTITNLTTITETDSVTITNTDSVTTTETDSTTVTNTTSVTTTETDSTTVTNTETDSATVTNTYIDSTTITETDTTTATVPTTTYTTRTIFSTTYEPCPKFCSISADTVSLYYWPTNKPYTYPATYYDRKLSYTFTSPSVYMLIPTAVGINSANQTAGPQTTSWILPLDLYDVSTIFAGTSTRQLTLNDLGTNCPQTVDPTAIASLPTECNPVLAAPTQVRKWAYPCNACGRFGMVDPPYAVPTLTGGLVIEPTTTRATTWLEGPSSAIPSSGTVGTAAPSPVTSVPAPTGTGTGTGTGTTTLAVVPGTDTDTHTATGVPGSASTDVPNSSGTFTETYTSTYTSTFTGSVPDPASTGEQGSAPTTTTASTAGGARLAVGEGVGMWLVSVGGVVIATFWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GZE6</accession>
    <name>A0AAJ0GZE6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">GPI biosynthesis protein family Pig-F-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_124404</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
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            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724758.1">
        <property type="nucleotide sequence ID" value="XM_062861681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GZE6"/>
    <dbReference type="GeneID" id="87880510"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009580">
        <property type="entry name" value="GPI_biosynthesis_protein_Pig-F"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06699">
        <property type="entry name" value="PIG-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3308978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="262" mass="27054" checksum="39FBE49E1F6D63AC" modified="2024-07-24" version="1">MPLVDPITMSSSLVKGAAAQAQATSSKAATVTSPSSTPLHPVQTKQTPLAQTARHALPALLAGLFLVRFGALVSDPVSAMTTALPVTAALQMSYAVLCLPAAGSQGAKPARKPRPGEKKRIGAEATGPNAFATSLLSLLLSLLVTPFLHAALVLFGAPFLTHGAHTLLCAAHLSLLALFPLFYVHGVDAAAWAAVGGFSAPFDETFGGLVGGAVGAWLGAVPIPLDWDREWQKWPVTILCGLYGGYVLGRVLGGTLLWGKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GZP8</accession>
    <name>A0AAJ0GZP8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ACT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_116914</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724505.1">
        <property type="nucleotide sequence ID" value="XM_062861572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GZP8"/>
    <dbReference type="GeneID" id="87880401"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2130.10">
        <property type="entry name" value="VC0802-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027795">
        <property type="entry name" value="CASTOR_ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051719">
        <property type="entry name" value="CASTOR_mTORC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31131:SF6">
        <property type="entry name" value="CASTOR ACT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31131">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13840">
        <property type="entry name" value="ACT_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CASTOR ACT" evidence="2">
        <location>
            <begin position="98"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3308725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="422" mass="44734" checksum="4859F4CA4EF55543" modified="2024-07-24" version="1">MTAQVSFLDGTLSLIHIPLDLYTSLLQPILKVVLPPSQDPTQSLQANLTSNSHKHGFLNISVTPIECSIVCNSAWAQSVFEPAIKRLPREQAKSVAISKDTYAALSVYGAGVDAGSRVADLTSPLALAGIPIFFITTYYSDFILVPIKDRQVVVKTLLGRGFVFSEDDQSQLISAQPSPTATSHNHHGFGIFGGYNGPPADNPPSSPAHNELSELQERTFDLLKRRHVTPHVEPGLTLVQCTGIRGAGINHASSLSHRSRGFGANGDSRRGSKTTPSWVDTIDTKLYTSVVAALVAQPHFLSVTLADEDPPSLLLDRELLGLFGDSVVGPTEGALVPIFLDLADLPFEATGIVSGVAGRLVREMGMGNGMAVGMGAVGGDGVGELSYLSTARAGAVILSREQAEMALRVLKPLLGREEPGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GZR3</accession>
    <name>A0AAJ0GZR3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_120894</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat cdt2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724630.1">
        <property type="nucleotide sequence ID" value="XM_062861621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GZR3"/>
    <dbReference type="GeneID" id="87880450"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051865">
        <property type="entry name" value="WD-repeat_CDT2_adapter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22852:SF0">
        <property type="entry name" value="DENTICLELESS PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22852">
        <property type="entry name" value="LETHAL 2 DENTICLELESS PROTEIN RETINOIC ACID-REGULATED NUCLEAR MATRIX-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="285"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="327"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="680"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="75"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="536"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3308850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="749" mass="81287" checksum="046ED029495BF4D9" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GZY9</accession>
    <name>A0AAJ0GZY9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Suppressor of anucleate metulae protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_509657</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3309278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725058.1">
        <property type="nucleotide sequence ID" value="XM_062867801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GZY9"/>
    <dbReference type="GeneID" id="87886630"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="P:methylation"/>
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        <property type="entry name" value="Rubisco_LSMT_subst-bd"/>
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        <property type="entry name" value="SETD3_SETD6_MTase"/>
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        <property type="entry name" value="Znf_MYND"/>
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        <property type="entry name" value="N-LYSINE METHYLTRANSFERASE SETD6"/>
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    </dbReference>
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        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
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    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81822">
        <property type="entry name" value="RuBisCo LSMT C-terminal, substrate-binding domain"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SET"/>
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        <property type="entry name" value="ZF_MYND_1"/>
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    </dbReference>
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        <property type="entry name" value="ZF_MYND_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="8">
        <location>
            <begin position="26"/>
            <end position="246"/>
        </location>
    </feature>
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        <location>
            <begin position="431"/>
            <end position="469"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
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            <dbReference type="ARBA" id="ARBA00022691"/>
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            <dbReference type="ARBA" id="ARBA00022723"/>
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        <source>
            <dbReference type="EMBL" id="KAK3309278.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
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    <sequence length="481" mass="53126" checksum="C804C2D8807CFFDC" modified="2024-07-24" version="1">MLLQPTLSTPNSMESWLKLSGAVGLDDLVLADFPVTGRGVRTLRRLKEGERILTIPCGNLWTVEHAYADPLLGPALRSARPPLSVEDALATYILFIRSRESGYDGLRSHVAALPTSYSSSIFFAEDELEVCAGASLYTITKQLDRSIENDYRALVVRVLGQYRDLFPLDKFTIEDYKWALCTVWSRAMDFVLPNGNSIRLLAPFADMLNHSSEVKPCHVYDVSSGNLSVLAGKDYEAGDQVFICYGPIPNSRLLRLYGFVLPGNPNDSYDLVLATHPHAPFFEQKHKLWVSAGLNSTCTISLTLTDPLPKNVLRYLRIQRLDESDLAVTALQQIDATEEKISDSNEAEVLRFLVESFSRLLDSFGTQLEKLEEQLAEGVYPSGGNAWAAAHVSLGEQRVLRLARKRAEDLLSAVESGSGNVRGSLSALARCANCEKVPAQLMLCGRCKAVPYCGRMCQVAHYKEHKAICRATASKSGSEMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H055</accession>
    <name>A0AAJ0H055_9PEZI</name>
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        <submittedName>
            <fullName evidence="4">Esterase-like activity of phytase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_128746</name>
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    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3309075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062861724.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87880553"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027372">
        <property type="entry name" value="Phytase-like_dom"/>
    </dbReference>
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        <property type="entry name" value="BLR7070 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37957:SF1">
        <property type="entry name" value="PHYTASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13449">
        <property type="entry name" value="Phytase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042505420" evidence="2">
        <location>
            <begin position="23"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="Phytase-like" evidence="3">
        <location>
            <begin position="162"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3309075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="575" mass="61491" checksum="CFDC795AB0077573" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H071</accession>
    <name>A0AAJ0H071_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GAF domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_126641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3309010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724790.1">
        <property type="nucleotide sequence ID" value="XM_062861693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H071"/>
    <dbReference type="GeneID" id="87880522"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033745">
        <property type="term" value="F:L-methionine-(R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000614">
        <property type="entry name" value="FRMsr_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051330">
        <property type="entry name" value="Phosphatase_reg/MetRdx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021:SF15">
        <property type="entry name" value="FREE METHIONINE-R-SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021">
        <property type="entry name" value="GAF/PUTATIVE CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01320">
        <property type="entry name" value="UPF0067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
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                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
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                <person name="Natvig D."/>
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                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Cros-Aarteil S."/>
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                <person name="Kuo A."/>
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                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
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                <person name="Chen C."/>
                <person name="Yanf M."/>
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                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
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                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
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                <person name="Hutchinson M.I."/>
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                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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                <person name="Daum C."/>
                <person name="Ng V."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 333.67</strain>
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    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
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                <person name="Kuo A."/>
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                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
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                <person name="Ng V."/>
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                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
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                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
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                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
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    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3309775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="351" mass="39105" checksum="BB92EAA961C31E59" modified="2024-07-24" version="1">MTELELVKNTVKLSEANENLARHLQMFGGRWWYEDGGCTSIVWWKPLTALIERRAKLIRDIVNSPEATKYRSHKNTQRASRLKDILAVFLPNDTDSKAAKDGVVYDISVIASTAWDVSAKVLEAPITFVFRFNDVNSLFVTEMHEELDSSTDPRQFWNEKCIPRNEHRSQRDQATRRINLKKYGNLLRQGDWWIDNGVKIFYHPRGDILEQDLVVNGAAGPGSDSAPALATSRDPRNSQDGELGLGALRGPAGTSEERRVSDHHRTCANPVGAIGEGSPASTATIDRESVERTGSRHPVGRSEMTETSCRQEAPNPVVFAPLQRPWNAMSTAVSRSMDASGTGPEKVPWRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H1K9</accession>
    <name>A0AAJ0H1K9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin-conjugating enzyme/RWD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_517614</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725941.1">
        <property type="nucleotide sequence ID" value="XM_062868317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H1K9"/>
    <dbReference type="GeneID" id="87887146"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23808">
        <property type="entry name" value="UBCc_UBE2W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000072">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="5"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3310161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="155" mass="17811" checksum="772AAF50C569980D" modified="2024-07-24" version="1">MSTQFAAKRLSKELSKINSSLPPGIELVSADNFEEWLLDIRVLDNNPLYQNQTYRLKFRFGSSYPIEPPEVVFVKLPDRPIPMHPHIYSNGIICLDLLGQQGWSPVQNVESVCMSLQSMLTGNSKNERPPGDDEFVRGNRLRPKDIEFYYHDNDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H222</accession>
    <name>A0AAJ0H222_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_547091</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726182.1">
        <property type="nucleotide sequence ID" value="XM_062870168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H222"/>
    <dbReference type="GeneID" id="87888997"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050308">
        <property type="term" value="F:sugar-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051806">
        <property type="entry name" value="HAD-like_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481">
        <property type="entry name" value="FRUCTOSE-1-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481:SF4">
        <property type="entry name" value="GLYCEROL-1-PHOSPHATE PHOSPHOHYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01135">
        <property type="entry name" value="C1.5.6:_HAD__Beta-PGM__Phospha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3310402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="246" mass="26065" checksum="8A628B3912E656DF" modified="2024-07-24" version="1">MGSTEPPQAAFSAPPETATFDGLLFDMDGTIIDSTDAVVKHWTSIGKEIGVDPEVILETSHGRRSIDTLKIIAPEKATPEYVQHMESQLPKLYGADAVEIPGARALLQDVIAHSTPWTIVTSGTVPLVTGWLNVLQLPTPDHLVTAESVANGKPDPACYLLGRERLGLGGGEKQVLVLEDSPAGIRAGKAAGCRVLAVVTSHTVEQVLSAGPDWVVRDLASVRLLQAGGEDGRVTLEIRDALAKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H239</accession>
    <name>A0AAJ0H239_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Chromosome disjunction protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Ribosomal RNA-processing protein 44</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B0T15DRAFT_36852</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the RNR ribonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726184.1">
        <property type="nucleotide sequence ID" value="XM_062864184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H239"/>
    <dbReference type="GeneID" id="87883013"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071031">
        <property type="term" value="P:nuclear mRNA surveillance of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09862">
        <property type="entry name" value="PIN_Rrp44-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.690:FF:000005">
        <property type="entry name" value="Exosome complex exonuclease dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000010">
        <property type="entry name" value="Exosome complex exonuclease DIS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.700:FF:000001">
        <property type="entry name" value="Exosome complex exonuclease exoribonuclease (Rrp44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041505">
        <property type="entry name" value="Dis3_CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022966">
        <property type="entry name" value="RNase_II/R_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033771">
        <property type="entry name" value="Rrp44_CSD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033770">
        <property type="entry name" value="RRP44_S1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF35">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RRP44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17849">
        <property type="entry name" value="OB_Dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17216">
        <property type="entry name" value="Rrp44_CSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17215">
        <property type="entry name" value="Rrp44_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01175">
        <property type="entry name" value="RIBONUCLEASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10" id="KW-0271">Exosome</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="PIN" evidence="17">
        <location>
            <begin position="85"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="RNB" evidence="18">
        <location>
            <begin position="517"/>
            <end position="850"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00077930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00081547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAK3310404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="987" mass="111223" checksum="FF89EF78DE79A8E5" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H2C2</accession>
    <name>A0AAJ0H2C2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST2</fullName>
            <shortName evidence="8">Oligosaccharyl transferase subunit OST2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_387706</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Endoplasmic reticulum membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the DAD/OST2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726319.1">
        <property type="nucleotide sequence ID" value="XM_062864402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H2C2"/>
    <dbReference type="GeneID" id="87883231"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003038">
        <property type="entry name" value="DAD/Ost2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10705">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT DAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10705:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT DAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02109">
        <property type="entry name" value="DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="8"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3310539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="163" mass="17205" checksum="703DAED1CE393346" modified="2024-07-24" version="1">MAPKQRNAAAHSSTTTSSIAAAPSAAATAPPSSAPVAVPKSAIAKTTHAGSTQSWDKIVSNVLTHYLDTTPQRTKLLDAFMAFLVAVGALQFLYCILAGNYPFNAFLSGFAATVGQFVLTASLRIQTTEANKGDFPSVSPERAFADYVVCSLILHFFCVNFIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H367</accession>
    <name>A0AAJ0H367_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BPL/LPL catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_499033</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726769.1">
        <property type="nucleotide sequence ID" value="XM_062867329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H367"/>
    <dbReference type="GeneID" id="87886158"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033819">
        <property type="term" value="F:lipoyl(octanoyl) transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10993:SF7">
        <property type="entry name" value="LIPOYLTRANSFERASE 2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10993">
        <property type="entry name" value="OCTANOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21948">
        <property type="entry name" value="LplA-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="2">
        <location>
            <begin position="58"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3310989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="398" mass="41749" checksum="59497279C26C5F2D" modified="2024-07-24" version="1">MRLRLRHLHLPSIHPHYIPYSLASRVQEHLRRQHLDFKDAQSHTSTSSSTGLLLPSSQPPPPTLISFTPSPIYTLGRRQTSPLTPSETARLTAPLQLPAPTPPPPPPSSSSSQGSSQGSSSSSEPASLLPVRLTHSPRGGLTTYHGPGQVVLWPVLDLKSRQHRQLTVRCWARALEDTTISTLGRVFRLAGFTTEDPGVWVSPSSSSSSSSPPTTTTRGRVGDDVGGGGGGDGGGGDVAKIAALGVHLRRHVTALGTAINVVMPGSGRGEGEGTTDERGNPWARIVACGLEGRGVTSVAGQLGGGVAEVDALLQRAGLEAGERGGRERGVAAAWAEELARRVEIAGGVEVVSAEETLALMEGLAARESDSAACEDWDERAGEEETAYLARIKELIGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H3E0</accession>
    <name>A0AAJ0H3E0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_489418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726545.1">
        <property type="nucleotide sequence ID" value="XM_062866598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H3E0"/>
    <dbReference type="GeneID" id="87885427"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034772">
        <property type="entry name" value="CPSF6/7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23204">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFIC FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3310765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="386" mass="40323" checksum="B12BCD58E8A52367" modified="2024-07-24" version="1">MAEEEFEIDVYGDSANDNGDIDHGEQNHGEGDHQGYEGEDASGGNADEQGHGDHGNYHGAPQDNMEDSAASRTQSGSPIPQQRPPQGVKRKEGSDDRPVDPGATTALLVSELNWWNTDDDIRGWVRQAGCEHELKDITFSEHKINGKSKGQAYVEFTSQQAATATKHRVDALSSEYSQPGQKRHTVIYSSPTHNPFRTLPKDAPNRAAKDGQGRGPSGPVYNDRGGGNFVGNNSFGGFRGGRGNFGAPRAGMNQGGYNRNFSGNNMGAFNANNMGFNNPMAGGGFGGGFNRGGMMGSGMRGGMRGGRGGGMNMMGGMPMGGGMPMGGMAGPMGGMGMMGGGMGGAMGAGMPGFQGMQPGFNPGFFGGANQSNEWQNPHGAKRARGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H3U1</accession>
    <name>A0AAJ0H3U1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_520218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        </citation>
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        </source>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Brannstrom I.O."/>
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                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
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                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
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                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
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                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
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                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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            <strain evidence="2">CBS 333.67</strain>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
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                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
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                <person name="Daum C."/>
                <person name="Ng V."/>
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                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 333.67</strain>
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    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <person name="Hensen N."/>
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                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
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                <person name="Ng V."/>
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                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
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                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
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                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
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    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
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                <person name="Kuo A."/>
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    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PIGL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.89" evidence="2"/>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717447.1">
        <property type="nucleotide sequence ID" value="XM_062870059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LXS1"/>
    <dbReference type="GeneID" id="87888888"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000225">
        <property type="term" value="F:N-acetylglucosaminylphosphatidylinositol deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993:SF11">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3301667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="290" mass="31513" checksum="8835186BFD2B6764" modified="2024-07-24" version="1">MDSGWLPALGAAAVVVPSLYVYTASVVSARFPTLRNKRICILIAHPDDEAMFFAPTVQALTRPGLGNHVKILCLSSGNADGLGETRKRELAKSGLILGLRKPDDVFVVDKPEFPDSMTTTWDTAKLSSLLCSAFAPNLARSRNTDAAPTASIDVLITFDDGGVSGHPNHISLYHGAKAFMSALMAGKSGWACPVDLYTLKSVSITRKYTGFLDIVATLFSWAWQADKKDKKHPGGLVFLNGLAGHGGIFTAWKAMVSAHKSQMVWFRYGWISLSRYMYINDLSLENAKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ0LXZ6_9PEZI</name>
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            <fullName evidence="2">DUF4604 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">B0T15DRAFT_497489</name>
    </gene>
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        <name type="scientific">Chaetomium strumarium</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717555.1">
        <property type="nucleotide sequence ID" value="XM_062867271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LXZ6"/>
    <dbReference type="GeneID" id="87886100"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027911">
        <property type="entry name" value="DUF4604"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15377">
        <property type="entry name" value="DUF4604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4604" evidence="2">
        <location>
            <begin position="8"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3301775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="199" mass="20797" checksum="B4D83B999118BAB0" modified="2024-07-24" version="1">MSRKITANNLQYTTTLPPFLARLRGQHTSETDRDAPDPILAARRRPAKPRSGSAEAEDAPLVVDEYGNTVVDITVGVDGTVKEKSEQAGSAGDAQNKDGDTSSSVAAAEGAAGEQLPGVIQAGAQRKKRKIGRVIGGADADEGESEETGWKEKEGAKTSKPATATAREPQESGDSAPAPKAKTKKKAKKIKLSFGDEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LY80</accession>
    <name>A0AAJ0LY80_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_561565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717839.1">
        <property type="nucleotide sequence ID" value="XM_062870557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LY80"/>
    <dbReference type="GeneID" id="87889386"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="189"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="479"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3302059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="578" mass="61807" checksum="DD30B9045A435687" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LYB5</accession>
    <name>A0AAJ0LYB5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_403663</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718002.1">
        <property type="nucleotide sequence ID" value="XM_062865221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LYB5"/>
    <dbReference type="GeneID" id="87884050"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1170:FF:000006">
        <property type="entry name" value="NOL1/NOP2/Sun domain family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1170">
        <property type="entry name" value="Sun protein, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049561">
        <property type="entry name" value="NSUN5_7_fdxn-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048889">
        <property type="entry name" value="NSUN5_RCM1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807:SF4">
        <property type="entry name" value="28S RRNA (CYTOSINE-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21148">
        <property type="entry name" value="NSUN5_fdxn-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21153">
        <property type="entry name" value="NSUN5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="7">
        <location>
            <begin position="129"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="324"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="564"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="336"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="366"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="579"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="628"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="449"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="237"/>
            <end position="243"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3302222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="642" mass="69822" checksum="CDBCE261D5734CE5" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LYP8</accession>
    <name>A0AAJ0LYP8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MFS transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_505583</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718349.1">
        <property type="nucleotide sequence ID" value="XM_062867532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LYP8"/>
    <dbReference type="GeneID" id="87886361"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23524:SF1">
        <property type="entry name" value="MRH DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23524">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="377"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="408"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="446"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="528"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="554"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3302569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="583" mass="61410" checksum="A6C25CD0BAAE0285" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZ01</accession>
    <name>A0AAJ0LZ01_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_259256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3302927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718707.1">
        <property type="nucleotide sequence ID" value="XM_062863300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZ01"/>
    <dbReference type="GeneID" id="87882129"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070224">
        <property type="term" value="F:sulfide:quinone oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070221">
        <property type="term" value="P:sulfide oxidation, using sulfide:quinone oxidoreductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000203">
        <property type="entry name" value="Related to sulfide:quinone oxidoreductase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015904">
        <property type="entry name" value="Sulphide_quinone_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10632">
        <property type="entry name" value="SULFIDE:QUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10632:SF2">
        <property type="entry name" value="SULFIDE:QUINONE OXIDOREDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="1">
        <location>
            <begin position="48"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3302927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="457" mass="49506" checksum="4BE45842BA2DCDD5" modified="2024-07-24" version="1">MASSRLLTTQAVSAAAAARHSFNKQAPAAYRTFASVSDVPVSPARNHKVVVVGGGSAGLTISHQLLRTGKFSQDDIAIVDPAEFHHYQPGWTLVGGGLKNKDELKRPLSSLVDPKLKLYPDSLATFSPQDNSVTLGSGAKLTYEQLVVAPGIKVDLSSIKGLPEAAANPESNVSSIYTFETVDKVFKTIQRLRGGQAIFTQPAGVIKCAGAPQKVMWLALDHWKRAGLYQAKSESSAVKIAFATGLPAMFGVPKYSAALEALRQERGVEGLFTHDLVEVDGNTAVFARPDGKEQVRRTFDLLHVVPKMGPHAFVKNSPLANEAGYVDVDDATLRHKKYGNVWSAGDASSLPTSKTAAAITSEAPVLVKNLMRVMEGNEKVEAGYDGYTSCPLLTEYGKVMLAEFKYGGVPKETFNVIGWDQATPRRAFYHLKKDFFPWVYYKSMVKGTWGGPNGWIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZ07</accession>
    <name>A0AAJ0LZ07_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_504197</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3302899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718679.1">
        <property type="nucleotide sequence ID" value="XM_062867491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZ07"/>
    <dbReference type="GeneID" id="87886320"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="33"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="123"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3302899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="327" mass="37245" checksum="A0CA8E597C2652D7" modified="2024-07-24" version="1">MMPSRNRSRQHGLGGSAPRTCHNCKQVGHIAWNCPQSAGPQSPKQKQSTLPHETRTSEQWSQQKRQIETMGAGAWQQGQERMEGELQQSLYHLHHEPLQMQNCLSQMAAHRPQHRHLQPLRPCLKQKTRPPSPAPAPQDQPSVLPPQQLPPTPAESSPEPESAPQHTNQPAPEVLTVTERLSILNGLSEALTKALYNTRNIITDHEQRLAQRETRPPRLDEITSFFGMLERTAEQATAQLREYHRASGHSSSHTLGDTEQQFCASWEMVVRGFAEVEDWERRFSERTTKDEDLDLVWEGYVAAMKEFGTLVKRFEEEHLMGDAEEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZ21</accession>
    <name>A0AAJ0LZ21_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_258943</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3302915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718695.1">
        <property type="nucleotide sequence ID" value="XM_062863296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZ21"/>
    <dbReference type="GeneID" id="87882125"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="31"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3302915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="385" mass="43433" checksum="17306A6EC7FB37D8" modified="2024-07-24" version="1">MPAFNHPGVSQNVFLGLIWAAEGLALLFLTIRLFTRIRTQRRIFWDDVLAIFAASLTVVVAALWQWQAPSMYQVLQVMAGLAPPGPGFIDKMLLWLKVQLISELFFYTGLVAVKLAFLLFFKRLGHNVNRFDWFWWPVFGFVLAVYAVNLGTVEYRCLLATVEDVVGYCSSRQSADFTAITLKFNCAMDVFSDFLIILIPVWLLWNVRIAFAKKLAFFGLFSLSLVTMAIATARAADLTATSWDNGVIDPSYLWMWTAIEPCIAIAVSCLSAFPQLFAASVNANKPAYKPTDTYLRMMSRIRSKRNLKKQHSEPTLYDLSSISQVDYVKAPETSSMEHLQPVLVPGPPQPMVVCYKTSHEADGAQMHGQIKRELGYQVTQQSGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZ26</accession>
    <name>A0AAJ0LZ26_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pectate lyase</fullName>
            <ecNumber evidence="10">4.2.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_259342</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Pectinolytic enzyme consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins. Favors pectate, the anion, over pectin, the methyl ester.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Eliminative cleavage of (1-&gt;4)-alpha-D-galacturonan to give oligosaccharides with 4-deoxy-alpha-D-galact-4-enuronosyl groups at their non-reducing ends.</text>
            <dbReference type="EC" id="4.2.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 10">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the polysaccharide lyase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.2" evidence="10"/>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3302930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718710.1">
        <property type="nucleotide sequence ID" value="XM_062863302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZ26"/>
    <dbReference type="GeneID" id="87882131"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004898">
        <property type="entry name" value="Pectate_lyase_PlyH/PlyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33407">
        <property type="entry name" value="PECTATE LYASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33407:SF9">
        <property type="entry name" value="PECTATE LYASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03211">
        <property type="entry name" value="Pectate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="8 10 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042317528" description="Pectate lyase" evidence="10">
        <location>
            <begin position="20"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3302930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="250" mass="25990" checksum="54B88890053CBDF9" modified="2024-07-24" version="1">MQPPVLAVLLSAGLASAAATNTNLQTKFPTATSTTGLPAVKTIAAGQKFDGQMLQWDRSPSTCKQQTETGDKDAVFILEDGATLSNVIIGPNNGEGIHCKGTCTLNNVWWTDVCEDAATFLQKSGTSYVNGGGARGASDKVLQHNGGGTVHVKNFLASNIGKLYRSCGNCKTQYKRASTFTNIRVTDKSSVVAGVNANYGDTTTIKDSCVLKGAICNVFQGNSNGKEPKKIASTPTGTACVAQAVKTSGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZ31</accession>
    <name>A0AAJ0LZ31_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_504255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3302974.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="142"/>
        </location>
    </feature>
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        <location>
            <begin position="784"/>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        </location>
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            <begin position="106"/>
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        </location>
    </feature>
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        <source>
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        </source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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            <strain evidence="4">CBS 333.67</strain>
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        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
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                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
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                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
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        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="project" value="InterPro"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657:SF7">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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        <source>
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</entry>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
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                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
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                <person name="Cros-Aarteil S."/>
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="GeneID" id="87889859"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3302975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="323" mass="36071" checksum="B72C7F096F5CB0FF" modified="2024-07-24" version="1">MASLSTEAPSTMDSLPRKVPPTMDSFPREVKLMILRQLDGLINPDSIRLIPYQQVFCSHTRTRHCFPNSRRPTTASFHFLIPAMDRPSSIVTAKMDGPTSTPASVTSAFERLESIELCSYPLDDELDHEIWCCGPLTAFANLIPEELDPLLSAPPYSQHAARNSLVLEWLAPSAPRAYTPGAPTPVYCAILTFDDIPDTKRLVRDFSLLLSADLDLSTVKYCDPVDERALARDVNASGKSLDADIAEDRRLVEKEEIPRRPGRCTRLRRQPQPPAPNRALMDVAPLPSRPARRRVHHLLLPRVAPRIRKVAYEGEAARRAGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZA8</accession>
    <name>A0AAJ0LZA8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_539243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Sordariomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062869722.1"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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            <end position="21"/>
        </location>
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        <location>
            <begin position="22"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3303123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="177" mass="18813" checksum="F99E5C7634229E50" modified="2024-07-24" version="1">MFQHWILSFLLLLVYAQQIHALEDLPAGVDIEEDTPGQVTINGDPTGNSTLGSDIPITATIFSGVPGPSTCRGNVIFQLTLPPPTPGAGPKQEQCYNLARVAGCGNFVASKEAGCEARLFSEPGCRMYLNTAVFIPELRAVGGMWRSVGLRCGVPAPDPESLGPPPLAGLMRRPGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ0LZG4_9PEZI</name>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">B0T15DRAFT_513544</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719130.1">
        <property type="nucleotide sequence ID" value="XM_062868045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZG4"/>
    <dbReference type="GeneID" id="87886874"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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        </location>
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        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="298"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3303350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="600" mass="65375" checksum="6C039CDDCBC858A9" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZT8</accession>
    <name>A0AAJ0LZT8_9PEZI</name>
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        <submittedName>
            <fullName evidence="3">Pectate lyase superfamily protein-domain-containing protein</fullName>
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    </protein>
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        <name evidence="3" type="ORF">B0T15DRAFT_487092</name>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
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                <person name="Natvig D.O."/>
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                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
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                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062866409.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87885238"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="GH55_beta13glucanase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
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        <property type="entry name" value="QRT3-like"/>
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    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="RHGA/B-epi-like_pectate_lyase"/>
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        <property type="entry name" value="PECTATE LYASE SUPERFAMILY PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
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    <dbReference type="PANTHER" id="PTHR33928">
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        <property type="entry name" value="Pect-lyase_RHGA_epim"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
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    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042535584" evidence="1">
        <location>
            <begin position="26"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="2">
        <location>
            <begin position="466"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="2">
        <location>
            <begin position="781"/>
            <end position="838"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3303766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1076" mass="116732" checksum="C60595C7311E493B" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZW6</accession>
    <name>A0AAJ0LZW6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">L-ornithine N(5)-monooxygenase [NAD(P)H]</fullName>
            <ecNumber evidence="4">1.14.13.196</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0T15DRAFT_285513</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-ornithine + NADH + O2 = N(5)-hydroxy-L-ornithine + NAD(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:41512"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78275"/>
            <dbReference type="EC" id="1.14.13.196"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-ornithine + NADPH + O2 = N(5)-hydroxy-L-ornithine + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:41508"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78275"/>
            <dbReference type="EC" id="1.14.13.196"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.196" evidence="4"/>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719609.1">
        <property type="nucleotide sequence ID" value="XM_062863625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZW6"/>
    <dbReference type="GeneID" id="87882454"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025700">
        <property type="entry name" value="Lys/Orn_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42802:SF1">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42802">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13434">
        <property type="entry name" value="Lys_Orn_oxgnase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3303829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="550" mass="60406" checksum="577E55EA2D7C3AD8" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M0H8</accession>
    <name>A0AAJ0M0H8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_242819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720254.1">
        <property type="nucleotide sequence ID" value="XM_062863087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M0H8"/>
    <dbReference type="GeneID" id="87881916"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3304474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="155" mass="17242" checksum="61A5BAE55C09B9F2" modified="2024-07-24" version="1">MSPHGKRLWPGTARRVETLELVLWSRWIVCGGVGWTTGFGGYIGRLVRCMLYRLSPPCRHDSRKERESAASAPYGYPVHFALLPAAHLAGITSVSEGCQAAYGNVRKDDILTPCCYTLGTLTFHTPLPACCPTNSRLRRPPRTALRKHARASWYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M0N6</accession>
    <name>A0AAJ0M0N6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GPI inositol-deacylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_250070</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
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    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAK3304655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_062863159.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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        <property type="entry name" value="NPHP3-like_N"/>
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        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
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    </dbReference>
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        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <begin position="79"/>
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            <begin position="370"/>
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            <begin position="662"/>
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        </location>
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        <location>
            <begin position="760"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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        </location>
    </feature>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="2">
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        </location>
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            <begin position="1"/>
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        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ0M0Q4_9PEZI</name>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
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                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
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                <person name="Haridas S."/>
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                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062865052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M0Q4"/>
    <dbReference type="GeneID" id="87883881"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3304608.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="300" mass="32658" checksum="FEAA3891DD7B7DE9" modified="2024-07-24" version="1">MAATTTIEVPHLGGIRAGYALSGGQYDPAKPTCVLINSMCTTVSLYKTQFADKTLTDAVNLLAIEPLGHGATSCHPAEHFTYWDSAAMALQVMDKLGIDRAFALGTSQGGWIVARMALLAPQRIRGLLLLGTSMDYESAESRAKHGCWDPKTLLAPFYDKWCSTTGPTPDFVVDDVWCGMVATLGFGSKGTPELVQFWTDTLRDVYRGDEGRRKLKMALACLLDRDGLVRRVRDITCPVYWLQGTEDAPFGTSLPAEHIKLFTSAKEATLTLVEGGGHYLNATSPEEVGSALLQMVNKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">B0T15DRAFT_415414</name>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720944.1">
        <property type="nucleotide sequence ID" value="XM_062865459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M160"/>
    <dbReference type="GeneID" id="87884288"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3305164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="109" mass="10993" checksum="C8B392D40BC8DD55" modified="2024-07-24" version="1">MSDPHPQGGNLFDMAKDGTKVPEDAAKPNVIPSVARPDQRGDQAGAGGLGSATLHQAADNALSGSGQGEIISAGGALPEDVGGKYSRDGGKQRGQQQTTPHGGRNQPSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M1R4</accession>
    <name>A0AAJ0M1R4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_493890</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721527.1">
        <property type="nucleotide sequence ID" value="XM_062866979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M1R4"/>
    <dbReference type="GeneID" id="87885808"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00876">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001856">
        <property type="entry name" value="RAS small monomeric GTPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="239"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="265"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3305747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="301" mass="32382" checksum="B73A5B64B72609CD" modified="2024-07-24" version="1">MKPPHAPSASDASQPPVPISITICGDGGCGKSSITLRLVRSQWTSEYDPTIEDSYSVTRRIDGVVYHLSLTDTAGQEEYRGMWASSNLGADAFLLVYDITSRDSLDALNYFNELIDMEAETRLDNAARARRAGLTNLNIAPTMPDIHHLNSFRPTGGAGSGAKTIPPVKIVAGNKCDLQESRQVPAAVGLDWARKHGCGFMETSARLEVNIEETFALIVRRVVEARRLAEMGVTDAELAANSRGMTKPLTPLPPGDEEDEKKGGGDGGNGGGRGTGMRGPNIKGDRVARGNGGFWKKLRCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M1R7</accession>
    <name>A0AAJ0M1R7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">26S proteasome regulatory subunit 6B homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0T15DRAFT_416683</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721590.1">
        <property type="nucleotide sequence ID" value="XM_062865476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M1R7"/>
    <dbReference type="GeneID" id="87884305"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000020">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000049">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000033">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="198"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3305810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="421" mass="46989" checksum="A2767820287691BF" modified="2024-07-24" version="1">MGDVLVENAANSVQPLKKTTPSTIPSIENFEGVPTEGGDEYATLKRLQRQLEYIQLQEEYIKDEQRSLKRELVRAQEEIKRIQSVPLVIGQFMEAIDQNTGIVQSSTGSNYVVRILSTLDREQLKPSSSVALHRHSNALVDILPPEADSSIAMLGADEKPDVTYADVGGLDMQKQEIREAVELPLTHFDLYKQIGIDPPRGVLLYGPPGTGKTMLVKAVANSTTANFIRVVGSEFVQKYLGEGPRMVRDVFRMARENAPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQTANVKVIMATNRADTLDPALLRPGRLDRKIEFPSLRDRRERRLIFTTIASKMSLAPEVDLDSLIVRNDPLSGAVIAAIMQEAGLRAVRKNRYNIIQADLEDAYSSQVKGTGDENKFDFYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M1V2</accession>
    <name>A0AAJ0M1V2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_210094</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721573.1">
        <property type="nucleotide sequence ID" value="XM_062862663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M1V2"/>
    <dbReference type="GeneID" id="87881492"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF189">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042524869" evidence="7">
        <location>
            <begin position="22"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3305793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="625" mass="69239" checksum="218F78C8F3023C1F" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M1Z7</accession>
    <name>A0AAJ0M1Z7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_435290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721738.1">
        <property type="nucleotide sequence ID" value="XM_062865814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M1Z7"/>
    <dbReference type="GeneID" id="87884643"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042583611" evidence="3">
        <location>
            <begin position="21"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3305958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="266" mass="27585" checksum="CA0B1260E676FC5C" modified="2024-07-24" version="1">MPHFAVTLPLLASMLALAHAEDFQLSAIARLPETPPTATAPPAPLPPKLGYPATTAPAEQKDGQDGQVFVLTQVPAGAAATGALGQDDAVCDEVAARIKPQLTPKPAYPGPLQGLATHLGGIQYDNCKEFSFNGGNAKLDGTDNFKKFSEERYTTFIVPIWAKVHELWEACGDKAGDFDEVKNEPCYKWAFEQCQASKAGSGTQNAATEEKKQPAAAQPGDSAAKPSGSGGGLLLFGGAGKSVVPHAVAVGVAGAAGLMAFLWVMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M2C8</accession>
    <name>A0AAJ0M2C8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_494296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3306184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721964.1">
        <property type="nucleotide sequence ID" value="XM_062867004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M2C8"/>
    <dbReference type="GeneID" id="87885833"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3306184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="49" mass="5688" checksum="3B8A0832C713728D" modified="2024-07-24" version="1">MDPNPLSDREKALEDKWIREKEKQMAKERAAKKESSKDTNTGAIVKEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M2F8</accession>
    <name>A0AAJ0M2F8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_500986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722054.1">
        <property type="nucleotide sequence ID" value="XM_062867388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M2F8"/>
    <dbReference type="GeneID" id="87886217"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3306274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="108" mass="11674" checksum="76E406DBE07AF523" modified="2024-07-24" version="1">MPFNFSFSSSASAVVVGSGSVNGHGATKGWAYKHEAYSNDNGSGVRTTKQRLGEAPATQTKVYDARGRPLLIDHANRANRRTDLDSVRGIEDVTEDCSSTIPENSWKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M321</accession>
    <name>A0AAJ0M321_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_529551</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722967.1">
        <property type="nucleotide sequence ID" value="XM_062869113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M321"/>
    <dbReference type="GeneID" id="87887942"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF29">
        <property type="entry name" value="ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23297">
        <property type="entry name" value="ACP_SdgA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="201"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3307187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="292" mass="31660" checksum="D7C6D88BF217126E" modified="2024-07-24" version="1">MLTQTKPQDGVFENMSYDDWRTCTAPKIQGSWNLHGLLPHNLDFFVMLASMSGVIGNPGQANYAAGNTFQDALAHYRRRLGLAATTLDLGAVRDVGYLAESSESSRYWTMSHLNRLTISEADIHFLVKSAITGHTADDEITPAQVVSGLTGTGIEEHQMQGSRWMRDGKLAIAFKAAAGARKGANIEADMEALLQAETVTSAASIVEGIMVKRIATALMMSEEDIGLSEPLQAYGVNSLVAVEIRTWLAKEFQAEITVGEISPSPIPTIALKLVRTSRLLKGKLREDGKEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M3K8</accession>
    <name>A0AAJ0M3K8_9PEZI</name>
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            <fullName evidence="2">Transcription factor TFIIIC triple barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">B0T15DRAFT_482717</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Sordariomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3307790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723570.1">
        <property type="nucleotide sequence ID" value="XM_062866118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M3K8"/>
    <dbReference type="GeneID" id="87884947"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019481">
        <property type="entry name" value="TFIIIC_triple_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009291">
        <property type="entry name" value="Vps62"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48171">
        <property type="entry name" value="DUF946 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48171:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 62"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TFIIIC_sub6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06101">
        <property type="entry name" value="Vps62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor TFIIIC triple barrel" evidence="2">
        <location>
            <begin position="25"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="572"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="584"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3307790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="897" mass="103545" checksum="02EF438B0754526E" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M3X6</accession>
    <name>A0AAJ0M3X6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_499756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
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            <taxon>Chaetomium</taxon>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="87886179"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042585905" description="Secreted protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3307849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="173" mass="19572" checksum="94A692F67DCAA8D2" modified="2024-07-24" version="1">MHLITIVVAALVAPFCILAAPLTATSTSTAYYNEVLDKRENLCNLSSPPQLCQPNSSVTIEETALRAYKFYRAFVVDGDPRTMFSLIDSVYKQNSPGYQSGPQAIWPLFCNGRKIGTEQNTAWCFDASTNMSYARYSVTDRWRWVDGCVHEHWDRNERIPSQDKCYKLPTGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M4A7</accession>
    <name>A0AAJ0M4A7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_104296</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Sordariomycetes</taxon>
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            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724064.1">
        <property type="nucleotide sequence ID" value="XM_062861404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M4A7"/>
    <dbReference type="GeneID" id="87880233"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
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</entry>
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                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
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                <person name="Ament-Velasquez S.L."/>
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                <person name="Barry K."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
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        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <person name="Bonometti L."/>
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
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                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
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                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
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                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
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                <person name="Kuo A."/>
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                <person name="Ohm R.A."/>
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                <person name="Ament-Velasquez S.L."/>
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                <person name="Barry K."/>
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                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 333.67</strain>
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        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Bonometti L."/>
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                <person name="Cros-Aarteil S."/>
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
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                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
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                <person name="Natvig D."/>
                <person name="Lalanne C."/>
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                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <proteinExistence type="predicted"/>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M5C1</accession>
    <name>A0AAJ0M5C1_9PEZI</name>
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    <organism evidence="8 9">
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    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725235.1">
        <property type="nucleotide sequence ID" value="XM_062864208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M5C1"/>
    <dbReference type="GeneID" id="87883037"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08999">
        <property type="entry name" value="GH43_ABN-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051795">
        <property type="entry name" value="Glycosyl_Hydrlase_43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812">
        <property type="entry name" value="BETA-XYLOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812:SF5">
        <property type="entry name" value="ENDO-ARABINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042525351" evidence="7">
        <location>
            <begin position="22"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="5">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3309455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="326" mass="34638" checksum="E764C7BBC7511BE5" modified="2024-07-24" version="1">MHLPITTLPLVLLATTDHALARPHETLGNLDFADPSITYDPHSSAWYAFATQANNKHVQVATAPSPRGPWTYLPSTDLLPVPGSWVDTTSPRIWAPDVQYLSESDRFVLYYSGLVAGGSPYHCVGAATAENITGPYTAQAEPLICPLDEGGAIDAAGFRDESDGSRWVVYKVDGSAKGPGGPCGNGDPPGVPTPLRLQRVDETDGVTLVGEAETILDRDPELDGPLVEAPSLVRAGGKFVLFYSSHCFNSPDYDVKYATAERIQGPYTRKGQLIGKQAGDYGLEAPGGATGVMGGLAMVFHANCPAGRCMYETEYVLEGGEIKIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M5M4</accession>
    <name>A0AAJ0M5M4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mss4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_506437</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725472.1">
        <property type="nucleotide sequence ID" value="XM_062867578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M5M4"/>
    <dbReference type="GeneID" id="87886407"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF3">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="6">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="118"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3309692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="146" mass="15723" checksum="86BD08BD5E5925F7" modified="2024-07-24" version="1">MNAACDCGAITFKTPTPKPLALYICHCSTCKKQAGSAFGTSAIYPRFPLPDTELLSCYKRPTTSGHTLYCYFCKQCGTRLIHTIPGKNVLSVKGGCIEGLDWTSAIHIWTKSAMVPIPEDSKSYSEGPGSSEYSEEFDPPSDGLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M5W8</accession>
    <name>A0AAJ0M5W8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Wax synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_517234</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the wax synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725835.1">
        <property type="nucleotide sequence ID" value="XM_062868303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M5W8"/>
    <dbReference type="GeneID" id="87887132"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044851">
        <property type="entry name" value="Wax_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032805">
        <property type="entry name" value="Wax_synthase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL O-FATTY-ACYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595:SF57">
        <property type="entry name" value="OS04G0481900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13813">
        <property type="entry name" value="MBOAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="260"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="320"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="448"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="486"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Wax synthase" evidence="10">
        <location>
            <begin position="359"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3310055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="559" mass="62361" checksum="66A58D6DBA5C840C" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M640</accession>
    <name>A0AAJ0M640_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ANTH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_385791</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726266.1">
        <property type="nucleotide sequence ID" value="XM_062864296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M640"/>
    <dbReference type="GeneID" id="87883125"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005545">
        <property type="term" value="F:1-phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032050">
        <property type="term" value="F:clathrin heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048268">
        <property type="term" value="P:clathrin coat assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16988">
        <property type="entry name" value="ANTH_N_YAP180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.150:FF:000004">
        <property type="entry name" value="ENTH domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000025">
        <property type="entry name" value="ENTH domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.150">
        <property type="entry name" value="ANTH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011417">
        <property type="entry name" value="ANTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014712">
        <property type="entry name" value="ANTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045192">
        <property type="entry name" value="AP180-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951">
        <property type="entry name" value="CLATHRIN ASSEMBLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951:SF5">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-BINDING CLATHRIN ASSEMBLY PROTEIN LAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07651">
        <property type="entry name" value="ANTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="4">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="278"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="398"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="297"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="432"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="483"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="505"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="529"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="582"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3310486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="636" mass="69797" checksum="E8FE3EA31B0CA510" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M6Q6</accession>
    <name>A0AAJ0M6Q6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alkaline-phosphatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_389757</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726690.1">
        <property type="nucleotide sequence ID" value="XM_062864508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M6Q6"/>
    <dbReference type="GeneID" id="87883337"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009141">
        <property type="term" value="P:nucleoside triphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16018">
        <property type="entry name" value="Enpp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.180:FF:000003">
        <property type="entry name" value="Type I phosphodiesterase/nucleotide pyrophosphatase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151:SF120">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151">
        <property type="entry name" value="ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="646"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="680"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="759"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="680"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="719"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="760"/>
            <end position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3310910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="779" mass="86726" checksum="5240139C1ECDC28F" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M784</accession>
    <name>A0AAJ0M784_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0T15DRAFT_387720</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>5-methyl-UTP(out) + UTP(in) = 5-methyl-UTP(in) + UTP(out)</text>
            <dbReference type="Rhea" id="RHEA:73523"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:63527"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727274.1">
        <property type="nucleotide sequence ID" value="XM_062864403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M784"/>
    <dbReference type="GeneID" id="87883232"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015218">
        <property type="term" value="F:pyrimidine nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990519">
        <property type="term" value="P:pyrimidine nucleotide import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000079">
        <property type="entry name" value="Mitochondrial carrier protein RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000088">
        <property type="entry name" value="Mitochondrial carrier protein RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049562">
        <property type="entry name" value="SLC25A33/36-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829:SF4">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="45"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="161"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="277"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00093195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3311494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="371" mass="40656" checksum="E93CED0F369AFA74" modified="2024-07-24" version="1">MPGGPEKRASHGDAPLTQSRETGDINPESRQGDPIVNRAKATPFAMSWAHMVAGGIGGMTAATLTAPLDVLKTRLQSDFYQAQLKASRAAHAGMNPIRAVTFHFGETASILASVYRQEGPRALFKGLGPNLVGVIPARSINFYTYGNGKRIIGEYLNVDKDSAWVHLSAGAVAGIVTSTATNPIWMVKTRLQLDKNMAIESGSIAKRRYRNSIDCIRQVLRDEGIRGLYKGMSASYLGVVESTMHWMLYEQIKRALVKREERLALSGRPKNWWDHTVDWTGKFGAAGFAKFVAAVVSYPHEVARTRLRQAPLADGRPKYTGLVQCFKLVFKEEGMLGLYGGMTPHLLRTVPSAAIMFGMYESILRLLGATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M7B4</accession>
    <name>A0AAJ0M7B4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_565211</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727498.1">
        <property type="nucleotide sequence ID" value="XM_062870663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M7B4"/>
    <dbReference type="GeneID" id="87889492"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="cupin_BLL6423-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="OryJ/VirC-like"/>
    </dbReference>
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        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
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        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
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        <property type="entry name" value="CUPIN TYPE-2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SLR2101 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3311718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="199" mass="21511" checksum="048F2DE9D7399F80" modified="2024-07-24" version="1">MSSYNLVPPRRVTASNLPLPSNVREDEHAEPGVEVKVDTLKTAPLLDGTLMRTVVATNKQIPTSNDGHGELPLDTVPGMGIVLPGGLNMYYLDVAPNTEGTMHRTTSTDYLVVISGKLSLMTPGSEAYSVQDGKPTYREAVETVCHAGEVVIQRGMMHALSNRTNEWVRLLVVVLSSEPNKVPVEGADGHKVLADTWLP</sequence>
</entry>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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    </gene>
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        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727392.1">
        <property type="nucleotide sequence ID" value="XM_062868598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M7E5"/>
    <dbReference type="GeneID" id="87887427"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3311612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="213" mass="22970" checksum="3C530AEDA299F535" modified="2024-07-24" version="1">MSVTHGVVSSRLRSCRGLEPECAPDFINPQLGVSAGLCTGTLLRVGRVAPSPNKGFCRSSSPVPTLPAFRLPVHHATTLCPTAAGSQSSHGSAPCSFLRISARPDPAWTADDSILHGNFPSEELRRESLQESLPADMMMLRRYRARAGGVALQRGINRHSRPGMSRGTGFEPCKLMDGVSSVPIRQHTHGIIASSLLLFDFPPYCDNSEHIVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ0GKX8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_563399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717577.1">
        <property type="nucleotide sequence ID" value="XM_062870615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GKX8"/>
    <dbReference type="GeneID" id="87889444"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="395"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="490"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="544"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="576"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3301797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="596" mass="63637" checksum="4213EFB30965B6F4" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GL96</accession>
    <name>A0AAJ0GL96_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_287807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
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            <taxon>Sordariomycetes</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3301965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717745.1">
        <property type="nucleotide sequence ID" value="XM_062863665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GL96"/>
    <dbReference type="GeneID" id="87882494"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40625:SF1">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE GLYCOGEN-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40625">
        <property type="entry name" value="GTP-BINDING PROTEIN ESDC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="312"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3301965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="450" mass="48523" checksum="BBE23D6F6A8DCC64" modified="2024-07-24" version="1">MERDSRRDRGAWKGCYNFKEITCEGDAGSVPKRNGGLKMGHAYYYYYELDGASETHDPFQPTTTTCPYLPGQTVNALWIPVEQSGRKRSASLTSLREEDFKTMDPASKFVSPRPAPSPPEPARRVGTAPLRMQQPKRPSRSPSPGSRWMFSPRKLFSRKSSCSSLKEAPSQTLRAEDERNLRSEGSRSRDISPESLRKFLVDDAPLDHETDEENRPALDIPEDIVEENEDDDNFATSAVSETGQFTGLSPPPQRALSPATAVPSATDSAARKSSPLFIPAAPTRPPPRAPTLKIPTSTRNSQSDFPISALRSQASPQSPDSASLPGFDLSEDEDDDEPFSGVDIDEEDDALPIPGTASSALDRPMMMAKNPFARNLAATLSTYSLPRTAGTEGKLSTPGVGGQPAALSAVAADEGNATSLLTGCEIPDAGLGDLVSELGWMADFIKGECA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GLR5</accession>
    <name>A0AAJ0GLR5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phenylalanine--tRNA ligase alpha subunit</fullName>
            <ecNumber evidence="5">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Phenylalanyl-tRNA synthetase alpha subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B0T15DRAFT_298571</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="5"/>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718043.1">
        <property type="nucleotide sequence ID" value="XM_062863790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GLR5"/>
    <dbReference type="GeneID" id="87882619"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00496">
        <property type="entry name" value="PheRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2330:FF:000002">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000028">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040725">
        <property type="entry name" value="PheRS_DBD3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003210">
        <property type="entry name" value="PRK04172.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF40">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18553">
        <property type="entry name" value="PheRS_DBD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 18" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="17">
        <location>
            <begin position="229"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK3302263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="512" mass="57714" checksum="AA1E0162A1994885" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GLW9</accession>
    <name>A0AAJ0GLW9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acetoacetate-CoA ligase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_577450</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718105.1">
        <property type="nucleotide sequence ID" value="XM_062871059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GLW9"/>
    <dbReference type="GeneID" id="87889888"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030729">
        <property type="term" value="F:acetoacetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005914">
        <property type="entry name" value="Acac_CoA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01217">
        <property type="entry name" value="ac_ac_CoA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002937">
        <property type="entry name" value="PRK03584.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921">
        <property type="entry name" value="ACETOACETYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921:SF1">
        <property type="entry name" value="ACETOACETYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="7">
        <location>
            <begin position="35"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="99"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="6">
        <location>
            <begin position="581"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3302325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="694" mass="75194" checksum="EE210A781E8EDFC8" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GM37</accession>
    <name>A0AAJ0GM37_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Anticodon-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_514493</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718238.1">
        <property type="nucleotide sequence ID" value="XM_062868126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GM37"/>
    <dbReference type="GeneID" id="87886955"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10480:FF:000005">
        <property type="entry name" value="Similar to RNA processing factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044281">
        <property type="entry name" value="IMP4/RPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734:SF3">
        <property type="entry name" value="RIBOSOME PRODUCTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="189"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3302458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="448" mass="50371" checksum="1173706DD2C40968" modified="2024-07-24" version="1">MGPSRNGRASSGGSLTLKTANKLKRQQLYVQQKKTTGKARHEERHRRRKEEAKDPELRRQRLEQNQPASIDKKRIWDEVDDDSLGAVVDVAQLKRRRLEQAEAAAAAEADAVTEENAEEKEDDDVDSMLGSDDEEDGEGNDEEDSGETHRERAQRQPSVAPSTTSTALDLTPDALASQFKYLFSEEPPAMPKILVTTGINGTVHKEAQEIASVFPNGQDPSGPKRFGYSKLTCPALATYIRRSAHRYGHKYSVREIAKFAKNRGYTALLIVHEDLKRPSQLSVCHLNEEDAPPGPTLTYTIRNYQPGKVIPGHGNATNHYPELLLNGFKTPLGLLTAKSMNTLFPPRPEISGRQVVTLHNQRDYIFFRRHRYIFREARPTEKNVVGADGKEMEGVKGIRAGLQEIGPRFTLKLRRVDKGIGRAGSEGDDALKWEWKAKMEKKRTRFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GM53</accession>
    <name>A0AAJ0GM53_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">3-dehydrosphinganine reductase</fullName>
            <ecNumber evidence="14">1.1.1.102</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B0T15DRAFT_514530</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the reduction of 3'-oxosphinganine (3-ketodihydrosphingosine/KDS) to sphinganine (dihydrosphingosine/DHS), the second step of de novo sphingolipid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>sphinganine + NADP(+) = 3-oxosphinganine + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22640"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57817"/>
            <dbReference type="ChEBI" id="CHEBI:58299"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.102"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="16">
            <dbReference type="Rhea" id="RHEA:22642"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.102" evidence="14"/>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718279.1">
        <property type="nucleotide sequence ID" value="XM_062868129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GM53"/>
    <dbReference type="GeneID" id="87886958"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047560">
        <property type="term" value="F:3-dehydrosphinganine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006666">
        <property type="term" value="P:3-keto-sphinganine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08939">
        <property type="entry name" value="KDSR-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000456">
        <property type="entry name" value="3-ketodihydrosphingosine reductase tsc10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022190">
        <property type="entry name" value="DUF3716"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045022">
        <property type="entry name" value="KDSR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550:SF3">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12511">
        <property type="entry name" value="DUF3716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="451"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="492"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="457"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="498"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="513"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK3302499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="791" mass="84382" checksum="23FA92524BDE8B18" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GMA5</accession>
    <name>A0AAJ0GMA5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">DNA ligase</fullName>
            <ecNumber evidence="16">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">B0T15DRAFT_300604</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">DNA ligase involved in DNA non-homologous end joining (NHEJ); required for double-strand break (DSB) repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 16">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="16"/>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718085.1">
        <property type="nucleotide sequence ID" value="XM_062863807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GMA5"/>
    <dbReference type="GeneID" id="87882636"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032807">
        <property type="term" value="C:DNA ligase IV complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07903">
        <property type="entry name" value="Adenylation_DNA_ligase_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07968">
        <property type="entry name" value="OBF_DNA_ligase_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000234">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000013">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3260.10:FF:000008">
        <property type="entry name" value="DNA ligase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044125">
        <property type="entry name" value="Adenylation_DNA_ligase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029710">
        <property type="entry name" value="LIG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45997">
        <property type="entry name" value="DNA LIGASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45997:SF1">
        <property type="entry name" value="DNA LIGASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00333">
        <property type="entry name" value="DNA_LIGASE_A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 16" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="12 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="19">
        <location>
            <begin position="458"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="20">
        <location>
            <begin position="768"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="20">
        <location>
            <begin position="935"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="714"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="714"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00043870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAK3302305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1044" mass="117147" checksum="54409D7CCF9127BC" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GMF4</accession>
    <name>A0AAJ0GMF4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Prenyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_569789</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718443.1">
        <property type="nucleotide sequence ID" value="XM_062870817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GMF4"/>
    <dbReference type="GeneID" id="87889646"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008412">
        <property type="term" value="F:4-hydroxybenzoate polyprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13959">
        <property type="entry name" value="PT_UbiA_COQ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1780:FF:000001">
        <property type="entry name" value="4-hydroxybenzoate octaprenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1780">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048:SF28">
        <property type="entry name" value="4-HYDROXYBENZOATE POLYPRENYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PRENYLTRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3302663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="387" mass="41346" checksum="E7A3BA60DE3F55CF" modified="2024-07-24" version="1">MKQHAPVGAVTAELRSRSPNVNTKSDQADAADTALSQQYGGRHVGGWVSHLPASWVPFVQLARLSPPAALALIYFPHLFGALLSAITYNSDSKSATHGPAPAFIFLRASAVLLLGSFFFSNAAHAWNDLIDAPLDAQVARTRKRPIPRGAITPRAAFVFAATQAVCAAGVLLFAFPDPVGAACYALPNVLATAYYPWAKRHTNLVQLVLGFCLAWGIVVGFTTVGLEPFTWRPYFGLGADARREVAGDGNPIPSLRVDVPAACLLLACVLWTTIYDTIYAHQDRKDDTKLGIRSMAVLYGDRTKPVLWLALFCMLGLLAGCGAAAGMAWPYFGISLAGCALSLGAMIASVELADAASCWWWFRYGFWLAGSSIAGGLAVDSVEIRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GNR2</accession>
    <name>A0AAJ0GNR2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Impact N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_401506</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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        </citation>
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            <strain evidence="4">CBS 333.67</strain>
        </source>
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        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        </citation>
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        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the IMPACT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAK3303306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062865113.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="IMPACT N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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                <person name="Guillou S."/>
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
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                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
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                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
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                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
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    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
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    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3303568.1"/>
        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GPB5</accession>
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    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
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                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
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                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
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                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
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                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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            <dbReference type="PubMed" id="37820761"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
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        <property type="nucleotide sequence ID" value="XM_062870536.1"/>
    </dbReference>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3303606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
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        </submittedName>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062869800.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87888629"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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    </feature>
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    </feature>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3303585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ0GQ21_9PEZI</name>
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        <recommendedName>
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        <name evidence="4" type="ORF">B0T15DRAFT_228921</name>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="87881746"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR039875">
        <property type="entry name" value="LENG1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22093">
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    </dbReference>
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        <property type="entry name" value="Cir_N"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="10"/>
            <end position="46"/>
        </location>
    </feature>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="1">Uncharacterized protein</fullName>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
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                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Bonometti L."/>
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                <person name="Kuo A."/>
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                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
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                <person name="Steindorff A."/>
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                <person name="Martin F."/>
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                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
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                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <feature type="non-terminal residue" evidence="1">
        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="56" mass="5940" checksum="C507ADAB4A2532EB" modified="2024-07-24" version="1" fragment="single">MSETRELCTTCPVPLCLFLSTVSQSFGCPTPIPAVQLDFPCSPSCSGLTGRIWCSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQQ9</accession>
    <name>A0AAJ0GQQ9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_240516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720182.1">
        <property type="nucleotide sequence ID" value="XM_062863061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQQ9"/>
    <dbReference type="GeneID" id="87881890"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="282"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3304402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="30325" checksum="B1CD798895A8B1BB" modified="2024-07-24" version="1">MNKNWNDRADKDLFFTILSVKNIGVISGSEWTTIGNHMRSLGYGFTNEGCRQHFQGLRRAQAKAENGAATDSPRRIDPTLNPITRRPGPGRGRPRKKSAAGAAAGAGGSVGSESQSPGAQQVGASPAGTVPGGPPMVQGTPAGGMPHGVPMHPQYPGVPGVSGAPPTPVSTASGAPGTPGMPTMPATQGVPMGQGPPMAQGQPMVQGQPMLAGQPQPTATMPGPGVAPQAPMTAPEQLAVDPSLDDGPEEEHAAKRQRLADSQDPSLDDEAVLNALAGHNNPTTPGEYTTEYTYGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GR39</accession>
    <name>A0AAJ0GR39_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial</fullName>
            <ecNumber evidence="10">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Succinyl-CoA synthetase beta chain</fullName>
            <shortName evidence="10">SCS-beta</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0T15DRAFT_486001</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>succinate + ATP + CoA = succinyl-CoA + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for GTP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10 12">Belongs to the succinate/malate CoA ligase beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="10"/>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720140.1">
        <property type="nucleotide sequence ID" value="XM_062866332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GR39"/>
    <dbReference type="GeneID" id="87885161"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042709">
        <property type="term" value="C:succinate-CoA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006104">
        <property type="term" value="P:succinyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000002">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000001">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000004">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00558">
        <property type="entry name" value="Succ_CoA_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005809">
        <property type="entry name" value="Succ_CoA_ligase-like_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001913">
        <property type="entry name" value="PRK00696.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01016">
        <property type="entry name" value="sucCoAbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815:SF1">
        <property type="entry name" value="SUCCINATE--COA LIGASE [ADP-FORMING] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="SUCCINYL-COA SYNTHETASE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001554">
        <property type="entry name" value="SucCS_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2 10" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="ATP-grasp" evidence="13">
        <location>
            <begin position="45"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="89"/>
            <end position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="364"/>
            <end position="366"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00063570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3304360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="443" mass="47616" checksum="959B8F690C2D5183" modified="2024-07-24" version="1">MFRLGRSRALASALGAPKVSPSARLPSIAQQQQRRALSIHEYRSADLLRQYGIDVPKGSVATTAAEAEAVAKQIGTDDMVIKAQVLAGGRGKGTFDNGLKGGVRVIYSPTEAKMFAEQMIGHKLITKQTGAGGRLCNAVYICERKFARREFYLAVLMDRASQGPVIVSSSQGGMDIEGVAKENPDAITTTYVDINVGVTDEMARGIATKLGFSEQCVEDAKDTIQKLYKIFLEKDATQIEINPLSETSDHKVMCMDAKFGFDDNADFRQKEVFNWRDTTQEDPEEVRAAEAGLNFIKLDGDIGCLVNGAGLAMATMDIIKLNGGQPANFLDVGGGATPAAIKEAFELITSDPKVSAIFVNIFGGIVRCDAIAHGLINTAKTLNLKIPIIARLQGTNVEQAHQLINDSGMKIFSIDDLQSAAEKAVQLSKVVKMGAWPPCSPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GRL4</accession>
    <name>A0AAJ0GRL4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_558831</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720592.1">
        <property type="nucleotide sequence ID" value="XM_062870488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GRL4"/>
    <dbReference type="GeneID" id="87889317"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="9"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3304812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="260" mass="30048" checksum="A2FD14996BFCC8C7" modified="2024-07-24" version="1">MDILIADRYRVERKIGAGGFGLVYSGTDLSLGEEVAIKLTFVRNNPEVLRGEKDTYDALDSRVGIPRVRWFGQEYDFYALVIDALGPSLEDLFNYCDRKFSLKTILLIADQAIARIKYIHSKGFLYRDIKPDNFLIGVGRQGNSLYMIDFGLAKELSNAERRKNIEGIPLGGTRQYASINNYNGRGRCLIADDLESFGYIFQGLKVKFATYINYTRGLAFDDKPDYLYLRRLFYRRFRAEGFTYDHVFDWTKKSFKEIQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GRM2</accession>
    <name>A0AAJ0GRM2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EKC/KEOPS complex subunit BUD32</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Atypical Serine/threonine protein kinase BUD32</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">EKC/KEOPS complex subunit bud32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0T15DRAFT_537730</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720616.1">
        <property type="nucleotide sequence ID" value="XM_062869646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GRM2"/>
    <dbReference type="GeneID" id="87888475"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF288">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="1"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3304836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="321" mass="35974" checksum="3E9B2EC4A6222A97" modified="2024-07-24" version="1">MTAAMTNITHIMLKSYTPPRVKRLINPSGGSCNIGEIDDTTVLKYPRIKEDMKRVQIEAKMLEVLGPHPRIVQSKGLTEDGLLLEFMPNGNVYDYLSVHPDVPLHRRLAWCVQAAEAVAYIHSRRVVHCDIRHDNFLLDANLDLKLADFQGQHFSPTGAIVLDGGSCESAKAWLPRHPPDRCNVRTDLFALGSALQFLITGAEVFPDLVRSSETDDDIMRWFHETEPEIERRFRAGEFPPADEHVCAAVTARCWRQLYTTADQVVADLKAIQAAIARGESPETCVALPNEHDQPCGERWLYGLCEEGEHLATPPSRNLIGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GS09</accession>
    <name>A0AAJ0GS09_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_433565</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720802.1">
        <property type="nucleotide sequence ID" value="XM_062865779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GS09"/>
    <dbReference type="GeneID" id="87884608"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF13">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN MOC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="53"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3305022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="575" mass="63150" checksum="9A5C7C8844EE774C" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GSZ1</accession>
    <name>A0AAJ0GSZ1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_574885</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721358.1">
        <property type="nucleotide sequence ID" value="XM_062870972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GSZ1"/>
    <dbReference type="GeneID" id="87889801"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="487"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="74"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="944"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1119"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="129"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1141"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1173"/>
            <end position="1186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3305578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1201" mass="133282" checksum="408DD01C265EE9EA" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GSZ9</accession>
    <name>A0AAJ0GSZ9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_493740</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721368.1">
        <property type="nucleotide sequence ID" value="XM_062866967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GSZ9"/>
    <dbReference type="GeneID" id="87885796"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF39">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08960)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epoxide hydrolase N-terminal" evidence="4">
        <location>
            <begin position="18"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3305588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="414" mass="45573" checksum="3AFE9E99AE86761F" modified="2024-07-24" version="1">MVDAGFGVVPLGIPGSPAPFSLHFSDADLNQLSSLVQTAVIGAPSFYNTHSVADSPDYAFGGTRDWLADAAEEWVKTFDWRAHETYWNSFPQFTINVTAPSDGQIFNLHFAALFSRNPDAIPILLSHGWPSSWIEFIPILELLTTKYTPETLPYHIIAPSIPDYGLSTRSNLTGTELDFHTAAEALNGLMKALGFDAYVAQGGDVGSGLTATLGAVYDECKAVHFNNFLLTSSERAGVAHLPVTREENTTFALGAQFLYAGTGYLLEQGTKPGTISLVLMTNPVAMLGWIGSMYAEASKYSVDTILQQVTWYWLTQSYGRSLWSYRSAWAAILRDDSRKLPSPLAITTKPLGYSWYPGEVLGVAKSWMEHWFPDNLCFYRAHESGGHFAAFDDPVGFLQDIEDFVAVVKTKVEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GT70</accession>
    <name>A0AAJ0GT70_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycoside hydrolase family 12 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_204377</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 12 (cellulase H) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721432.1">
        <property type="nucleotide sequence ID" value="XM_062862616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GT70"/>
    <dbReference type="GeneID" id="87881445"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002594">
        <property type="entry name" value="GH12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002">
        <property type="entry name" value="BLR1656 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002:SF10">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01670">
        <property type="entry name" value="Glyco_hydro_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042498407" evidence="3">
        <location>
            <begin position="16"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3305652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="249" mass="27130" checksum="ABAF8A68A7BD0D23" modified="2024-07-24" version="1">MKLLLLSLVSSLAAASPLQANSLEARQQATLCDQYGYWSGNGYEVNNNNWGRSAASSGSQCTYVDGSSSNGIQWRTTWTWQGGENNVKSYANAGRQVTRGRKISSIGSMQTSVSWSYSNTNIRANVAYDVFTAADPNHVNSSGDYELMIWLARYGNVYPIGSSVGTVNVAGRTWELWVGYNGSMKVFSFIAPSPVNSFSANVKDFFNYLQNNQGYPANDQHLIVFQLGTEPFTGGPATLTVSQFSANIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GTA6</accession>
    <name>A0AAJ0GTA6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_485260</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721479.1">
        <property type="nucleotide sequence ID" value="XM_062866282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GTA6"/>
    <dbReference type="GeneID" id="87885111"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="34"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="120"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="153"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3305699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="800" mass="87465" checksum="271D291FFC7CE6FF" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GTE1</accession>
    <name>A0AAJ0GTE1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0T15DRAFT_567633</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721583.1">
        <property type="nucleotide sequence ID" value="XM_062870731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GTE1"/>
    <dbReference type="GeneID" id="87889560"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF12">
        <property type="entry name" value="MITOCHONDRIAL ORNITHINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="23"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="114"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="216"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3305803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="305" mass="33195" checksum="67E824608D0C17D5" modified="2024-07-24" version="1">MADSAADVEAWEGSGSSSAAQTAKDLFSGAAGGIAQVLIGQPFDIVKVRLQTSTTYPSAFSAATSIWRHEGPLAFYKGTLTPLLGIGACVSIQFGAFHSARRWLEQRKERGKGLGYGEYYAAGAFAGIANTVLSCPIEHVRIRLQTQPHGAARLYNGPWDCVRKLSAQGGVGGGVYRGTAITLLREAQAYGVWFLAFEWLMNADATRNKIERKDVPSYKVAFYGGLAGEALWLGSYPFDVVKSKMQTDGFGEQQRYKTMRDCFRQTWQAEGMRGFWKGIGPTLLRAMPVSAGTFAVVEMTMRAIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GTP5</accession>
    <name>A0AAJ0GTP5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methionine synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_215384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721763.1">
        <property type="nucleotide sequence ID" value="XM_062862729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GTP5"/>
    <dbReference type="GeneID" id="87881558"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005085">
        <property type="entry name" value="PRK06520.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43844">
        <property type="entry name" value="METHIONINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43844:SF1">
        <property type="entry name" value="METHIONINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE C-terminal/archaeal" evidence="1">
        <location>
            <begin position="13"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3305983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="389" mass="43381" checksum="68591C996F331871" modified="2024-07-24" version="1">MPLPAGVYRADHVGSFLRPKPILTARETLDTANPISPSDLRALEDEHIATVVQKQIASGLQSVTDGEFRRAWFHIDFLQHLAGVERHGSLSSTNVTSHGVTPPKIVVVGKLGHPEAVQVKDYQYVEAVRSRLVDAAGGKKEEKVTTTKVCIPSPTMVHFRGGREAISTEVYPTLDEFFEDLVKVYQAEIADLYAAGCRFVQLDDTNLAYLCDEGMRAEAAKRHGEDPQKLTKQYAALINAAISQRPKDMVIGIHLCRGNFRSQWFAEGGYEPVAEVLFRELNVDVYFLEYDDARSGDFSPLRFLPENKIVVLGVMSSKKAELDDKEDIVRRLNEAAKFCPRGLDQLCLSHQCGFSSTMEGNDLTEEQQWAKVRLEVEIAKQVWGDDLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GTQ4</accession>
    <name>A0AAJ0GTQ4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0T15DRAFT_556214</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPII-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721550.1">
        <property type="nucleotide sequence ID" value="XM_062870411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GTQ4"/>
    <dbReference type="GeneID" id="87889240"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF4">
        <property type="entry name" value="SECRETORY 24CD, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="12">
        <location>
            <begin position="311"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="13">
        <location>
            <begin position="390"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="15">
        <location>
            <begin position="643"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="14">
        <location>
            <begin position="739"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="11">
        <location>
            <begin position="871"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="124"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3305770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1009" mass="110214" checksum="58E0045873BAF555" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GTQ6</accession>
    <name>A0AAJ0GTQ6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C-5 sterol desaturase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_214130</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721687.1">
        <property type="nucleotide sequence ID" value="XM_062862711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GTQ6"/>
    <dbReference type="GeneID" id="87881540"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="7">
        <location>
            <begin position="156"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3305907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="328" mass="38261" checksum="FB558CFFEA958D21" modified="2024-07-24" version="1">MDTALDILDPLVFDKAYAYFVPARSVQPNATAHGALGLGRFSSDFAAASGSHGSAWARDNILRQCISIMIITQIGATSLYWIFSALSYYFIFDRRLEYHPRFLKNQVRQEIVSSMKAVPWINVLTLPFFLAEVRGYSLLYTDVDEYGWAWMGISTVLFMIWNDFLIYWIHRLEHHPSVYKYIHKPHHKWIVPTPWAALAFHPVDGWVQSLPYHVFVFVCPVQKYLYMVLFVLVQIWTILIHDGDMITGHWLEKYINSPAHHTLHHIYFTVNYGQYFTWADSYFKSHRPPQPDLDPLHDALRVMREKGLVDEKGQPIPGAKEKDKKKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GUA0</accession>
    <name>A0AAJ0GUA0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_526916</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722087.1">
        <property type="nucleotide sequence ID" value="XM_062868933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GUA0"/>
    <dbReference type="GeneID" id="87887762"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15761">
        <property type="entry name" value="FYVE1_Vac1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15737">
        <property type="entry name" value="FYVE2_Vac1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.20">
        <property type="entry name" value="Rabenosyn, Rab binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052727">
        <property type="entry name" value="Rab4/Rab5_effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006642">
        <property type="entry name" value="Rad18_UBZ4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021565">
        <property type="entry name" value="Rbsn_Rab-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036531">
        <property type="entry name" value="Rbsn_Rab-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510">
        <property type="entry name" value="FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510:SF44">
        <property type="entry name" value="RABENOSYN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11464">
        <property type="entry name" value="Rbsn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00734">
        <property type="entry name" value="ZnF_Rad18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140125">
        <property type="entry name" value="Rabenosyn-5 Rab-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
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        </location>
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    <feature type="coiled-coil region" evidence="7">
        <location>
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        </location>
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    <feature type="compositionally biased region" description="Gly residues" evidence="8">
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        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="8">
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        </location>
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        <location>
            <begin position="569"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3306307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="683" mass="75573" checksum="2FAE71F713DD7573" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
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                <person name="Kuo A."/>
                <person name="Mondo S."/>
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                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
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                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
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                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
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    <dbReference type="GeneID" id="87881647"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR39608">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39608:SF1">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G08640)"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        </location>
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        </source>
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            <dbReference type="Pfam" id="PF01284"/>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ0GUG1_9PEZI</name>
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        </recommendedName>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722062.1">
        <property type="nucleotide sequence ID" value="XM_062870282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GUG1"/>
    <dbReference type="GeneID" id="87889111"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3306282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="33964" checksum="6317B192C9447820" modified="2024-07-24" version="1">MARTKMTAKRYRRVTTLTRFHLPREQEWPTWPVDHPNVHIGPLADVQGAWKLRVGRMVEEPEQAAYIIEWRDLSNLEDFLSSPACAQFLRNLPEEVSDSVKSSSSALGSLTLEDAPPAASRFLILEEITHIPHGEVEGRITLNAFLVAGKCVPSTGWPPYKALREVFGSFQPRGSEFIRGHGARWGARWQQYKTTWFWVLAEDGWVESKFGKKSEPDQDRTVICEFHRWPREWGVTPEHEEASAADPQARESWNEAVAKVMPPVTAWVQERWDIRKVPLFDPEEDIDLDDIEHEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GUS7</accession>
    <name>A0AAJ0GUS7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
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    </protein>
    <gene>
        <name evidence="23" type="ORF">B0T15DRAFT_492099</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:16638"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">In the N-terminal section; belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722342.1">
        <property type="nucleotide sequence ID" value="XM_062866839.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87885668"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030436">
        <property type="term" value="P:asexual sporulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030448">
        <property type="term" value="P:hyphal growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14879">
        <property type="entry name" value="MYSc_Myo17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000337">
        <property type="entry name" value="Chitin synthase 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000012">
        <property type="entry name" value="Chitin synthase ChsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000017">
        <property type="entry name" value="Chitin synthase ChsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000055">
        <property type="entry name" value="Chitin synthase ChsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036037">
        <property type="entry name" value="MYSc_Myo17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF45">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109715">
        <property type="entry name" value="DEK C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 17" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 17" id="KW-0505">Motor protein</keyword>
    <keyword evidence="10 17" id="KW-0518">Myosin</keyword>
    <keyword evidence="7 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="873"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="912"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1184"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1579"/>
            <end position="1600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1606"/>
            <end position="1627"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1634"/>
            <end position="1657"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="21">
        <location>
            <begin position="1"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="20">
        <location>
            <begin position="936"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="domain" description="DEK-C" evidence="22">
        <location>
            <begin position="1805"/>
            <end position="1860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="583"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="104"/>
            <end position="111"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00046342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAK3306562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1863" mass="206350" checksum="927999F7B20956F5" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GV18</accession>
    <name>A0AAJ0GV18_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ZIP zinc transporter-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_492131</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722377.1">
        <property type="nucleotide sequence ID" value="XM_062866843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GV18"/>
    <dbReference type="GeneID" id="87885672"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16950">
        <property type="entry name" value="ZINC TRANSPORTER SLC39A7 HISTIDINE-RICH MEMBRANE PROTEIN KE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16950:SF16">
        <property type="entry name" value="ZINC TRANSPORTER ZIP13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042524214" evidence="7">
        <location>
            <begin position="29"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="192"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3306597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="435" mass="45378" checksum="D95F2D0F97A6EDB1" modified="2024-07-24" version="1">MAFFQLRRSRAAVLLLLATLTVVHLAGASTTSTEKGDDLPSLETLSLSELDDQLQQCPIVSTLSAAKATAHAAAPSSLTTRLFALLFPSSHPAVNALLATAYISGPPNLLLALCPTHIDPSSLSVMVAFAVGGLLGDTLFHLLPEIFLGEDEADRARFVLVEPNRNLLLGVAILVGFLVFVAMDKALRIATGGGGGHDHSHGHSHGHGHGHGQDADGRGKATALEGDGHEVRRRKGKKEVEGEGEGEGEVAEKGKAADANPSVKLGGILNMIADFTHNITDGLAMSASFYASPTIGATTTVAVFFHEIPHEVGDFALLVQSGFSKRQAMGAQFVTAIGALIGTLIGIAVQELGGNGGDDGAAMSMRDGLWGTSLTWGDMLLPFTAGTFLYVGTVAVIPELLETGPNKAAELRKTLQQFAAVLLGAGIMLYISWHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GV69</accession>
    <name>A0AAJ0GV69_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="17">RAD5-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B0T15DRAFT_412725</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722230.1">
        <property type="nucleotide sequence ID" value="XM_062865411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GV69"/>
    <dbReference type="GeneID" id="87884240"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16509">
        <property type="entry name" value="RING-HC_HLTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014905">
        <property type="entry name" value="HIRAN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF11">
        <property type="entry name" value="FAMILY HELICASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G06590)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08797">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00910">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="351"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="669"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="739"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="717"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="572"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="51"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK3306450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="910" mass="101169" checksum="F3A7C5A96BF99AD6" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GV82</accession>
    <name>A0AAJ0GV82_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pre-mRNA splicing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_149653</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWC26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722454.1">
        <property type="nucleotide sequence ID" value="XM_062861974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GV82"/>
    <dbReference type="GeneID" id="87880803"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070274">
        <property type="term" value="C:RES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018609">
        <property type="entry name" value="Bud13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051112">
        <property type="entry name" value="CWC26_splicing_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31809">
        <property type="entry name" value="BUD13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31809:SF0">
        <property type="entry name" value="BUD13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09736">
        <property type="entry name" value="Bud13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="17"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="256"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3306674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="344" mass="37658" checksum="645D992F04368BD8" modified="2024-07-24" version="1">MPSDKAAYLAAHYLTAETKPSSSKKRKRKQTAASSGLIIADDDETGWDASRHKNAEAEDDDIPMTIAGTTTEFRRAKKSGWKTIAGSTSTNARSPSSKEDAASAAAADAIIASVAAERTAAAAAEEAEAEADIPLMSNGAQAGLQSAAALSAQLRRRQQLEAEELAALKRANQQQQEQEEVILRDATGRRVDASLRRAEMRRQQQEAERAAREKQELLRGEVQAAQAKERRERLEEAALIPLARGKDDAELNEELKRRDRWNDPMAPFLGANDGDGGGGGKGKKKRAGKRPVYTGPAPPNRYGIRPGYRWDGVDRGNGFEAERFKALNRREMNKGLDYAWQMDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GVK5</accession>
    <name>A0AAJ0GVK5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_527888</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722440.1">
        <property type="nucleotide sequence ID" value="XM_062869000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GVK5"/>
    <dbReference type="GeneID" id="87887829"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3306660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="79" mass="8734" checksum="08568783D0EAA067" modified="2024-07-24" version="1">MTTVRSTGLLFTTQFLHYFLSFRGTAALMIGANITVHHHPSSHAFPAFRSLQRSGITLVGNKEFTTGHGRSISMTRQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GVV1</accession>
    <name>A0AAJ0GVV1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">dolichyl-phosphate beta-glucosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.117</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0T15DRAFT_529217</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a di-trans,poly-cis-dolichyl phosphate + UDP-alpha-D-glucose = a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate + UDP</text>
            <dbReference type="Rhea" id="RHEA:15401"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.117"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:15402"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.117" evidence="4"/>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722888.1">
        <property type="nucleotide sequence ID" value="XM_062869094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GVV1"/>
    <dbReference type="GeneID" id="87887923"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004581">
        <property type="term" value="F:dolichyl-phosphate beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04188">
        <property type="entry name" value="DPG_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035518">
        <property type="entry name" value="DPG_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10859:SF91">
        <property type="entry name" value="DOLICHYL-PHOSPHATE BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10859">
        <property type="entry name" value="GLYCOSYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="15">
        <location>
            <begin position="207"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="152"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3307108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="448" mass="49572" checksum="A694982DB50DEEFB" modified="2024-07-24" version="1">MATDGLIESLVQLVWLLWESAYNQPVNFVLTLALPLAGLSIFGIYIILHLVAPKPRLPFPSEKTYLTTNPDGTVSAPRPLPCWYDRWRAEGRLSQEYPTIPAGFPVTDQATIEPAEVEVSVVVPAYNEEARICPALEDMVEYLDQQFGRPNEQTLQREQQQEKPALETGRKDKRPTTPHRLVFKPDSTSPPPRSATGRTVSMDAAPSGYEILIVDDGSRDRTVEVVLDFSRRRGLHDILRVVKLEKNRGKGGAVTHGLRHVRGKYAVFADADGASRFSDLGRLIEGCEDVVDGSNRGVAIGSRAHLVASEAVVKRAAIRNFLMRSFHFVLMILTPPATSRIRDTQCGFKLFSRAALPHIVPYMHTEGWIFDIEMLMLAESAPATPVLASDGSVIGTSYGIKVAEVPVGWHEVDGSKMHLVQDSVRMAIGLAVLRASWMLGVYRRRVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GW86</accession>
    <name>A0AAJ0GW86_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_395501</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723081.1">
        <property type="nucleotide sequence ID" value="XM_062864787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GW86"/>
    <dbReference type="GeneID" id="87883616"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20339">
        <property type="entry name" value="BRcat_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20353">
        <property type="entry name" value="Rcat_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16630">
        <property type="entry name" value="RING-HC_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047545">
        <property type="entry name" value="BRcat_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051628">
        <property type="entry name" value="LUBAC_E3_Ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047546">
        <property type="entry name" value="Rcat_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047544">
        <property type="entry name" value="RING-HC_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770:SF47">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770">
        <property type="entry name" value="UBIQUITIN CONJUGATING ENZYME 7 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26200">
        <property type="entry name" value="Rcat_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="236"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="500"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="204"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="533"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3307301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="666" mass="74924" checksum="DBF59F73F7FFC021" modified="2024-07-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GWC7</accession>
    <name>A0AAJ0GWC7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_174735</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723141.1">
        <property type="nucleotide sequence ID" value="XM_062862241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GWC7"/>
    <dbReference type="GeneID" id="87881070"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05325">
        <property type="entry name" value="carb_red_sniffer_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF7">
        <property type="entry name" value="NADB-LER2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3307361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="268" mass="28214" checksum="95F7B924750D912A" modified="2024-07-24" version="1">MADHTVYLITGANRGIGLAITSLLLTRPNTTVIATSRKPLSLSAVGGANVHPTSKLVPVLLDEVDPAITSATLPARLTAEHGITHLDVVIANAGTSSAFEGVMSSSASTTGADPGKAMLRDFEVNAVGPARLFGALWPLLDSHRERADEDREGMRKVKKFVLMSSSLGSIGALEQESLPGVSYGMSKAAANWWAKKVSVELKGRLLVGIIHPGWVQTGLGQALASAVGFGEPPTTPEQSAKAVVEQIDNLTPEKSGQFLKYNGEQLPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GX02</accession>
    <name>A0AAJ0GX02_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CTLH/CRA C-terminal to lish motif domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_392984</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the proteasome-dependent degradation of fructose-1,6-bisphosphatase.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723414.1">
        <property type="nucleotide sequence ID" value="XM_062864668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GX02"/>
    <dbReference type="GeneID" id="87883497"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTLH" evidence="2">
        <location>
            <begin position="96"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3307634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="276" mass="30385" checksum="A1315DB82975D808" modified="2024-07-24" version="1">MSIRSAALELGGHDINSTLRDAVFAQLRESFGRMNSSTSTATTPQHAFEKQAADVKAPKSDINALILDYLTMEGYPKAAAKFCKEANLQPQQPDDSIQTRHAIQHAIHSGNIESAISALNELDPGILDTDPELHFSLLRLQMVELIRKCNGGDVTPAVDFAVEKLGPRAATNKKFLVELEKTMSLLIFPHDSLQPELAALLSSDLRRDTATKVNEAVLLRKNERREAAIRQLVRMRAWAETSARSKNKDLPDSIELGLNADSMEHGAGQHEPMITT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GX27</accession>
    <name>A0AAJ0GX27_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Beta-glucuronidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_522396</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3307731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723511.1">
        <property type="nucleotide sequence ID" value="XM_062868626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GX27"/>
    <dbReference type="GeneID" id="87887455"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052974">
        <property type="entry name" value="GH79_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031728">
        <property type="entry name" value="GlcAase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183:SF3">
        <property type="entry name" value="BETA-GLUCURONIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16862">
        <property type="entry name" value="Glyco_hydro_79C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-glucuronidase C-terminal" evidence="2">
        <location>
            <begin position="421"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3307731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="532" mass="58111" checksum="B0BA4D0033190945" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GX86</accession>
    <name>A0AAJ0GX86_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_549668</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the D-alanine--D-alanine ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3307823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723603.1">
        <property type="nucleotide sequence ID" value="XM_062870225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GX86"/>
    <dbReference type="GeneID" id="87889054"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008716">
        <property type="term" value="F:D-alanine-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011095">
        <property type="entry name" value="Dala_Dala_lig_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23132">
        <property type="entry name" value="D-ALANINE--D-ALANINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23132:SF23">
        <property type="entry name" value="D-ALANINE--D-ALANINE LIGASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07478">
        <property type="entry name" value="Dala_Dala_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="4">
        <location>
            <begin position="138"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3307823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="374" mass="40767" checksum="12F134354C1542C8" modified="2024-07-24" version="1">MTTAAATGSTKARVAVVFQALDPPIINGVRKPKKPNGYRDSGADIAYNLRQVEGIKVICPVPDPKPDRDVDWCFQDTEEDILQALDQGATHLWANTILFAAHPLQTSVRIGAFQDKACVVGQGPLAIEKYDDKNYVNSLLRRAGGFTLPRSWTMTASSSSNIGEARFPRSLLPLAKELPYPIVAKPIRGRGSHGVRVCHNMDELVQHAPRLFEESPAIMVEEFLAGEEATVTVMPPLPAVGKADYWALPVVTRFNHVDGIAPYNGVVAVTKNSRAVMDECVRAARLLRVAAPIRIDVRRLDQSPRSKFALFDVNMKPNMTGPGRPGRDDQASLTLIAAAALGWDYKTLLSHMLMTSCPLATLRGLKPVNSGSEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GXX5</accession>
    <name>A0AAJ0GXX5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_490803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723991.1">
        <property type="nucleotide sequence ID" value="XM_062866720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GXX5"/>
    <dbReference type="GeneID" id="87885549"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3308211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="386" mass="42077" checksum="C7D0FB233FA9CC75" modified="2024-07-24" version="1">MDDNRGHRRQDEPPVYPASSSRQHQPLHGPSQHRAHSFAGAQGGRFRPAPIATSAPGTTRGIGGSTGYSTYYSEHPAASFSTTALPQGAMGYHSTADYGQADSRQQQSFGGTYPPTMMYNVQQTGGPQATSVYDASPQYPSRQAAALPMMATDVTGPYFPSEPTNAAGPSALQAQAASSSTAQVYQQPGLHGYSTGSMATMGGMATSQTTPTPDVRMDEEYPTTAGLDEAYTSYQTALKEIFQNIRNGVLADASESLLGVSDWLLNHVVELGLTSDDQNLHEERIKLWNDFNHAWLAIFQRQKEMMESGQQLQRTQTLIPHEGLKKMGKSLVRYCDNIERHGLVDYQYGVWEEQIVDILGECLTLYESAIQPTGDGGEGIPDEQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GXX8</accession>
    <name>A0AAJ0GXX8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_101664</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062861364.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87880193"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="CDD" id="cd13952">
        <property type="entry name" value="7tm_classB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF22">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05462">
        <property type="entry name" value="Dicty_CAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="7">
        <location>
            <begin position="13"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="8">
        <location>
            <begin position="27"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="243"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="472"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="258"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="311"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="325"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="493"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3308218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="508" mass="55806" checksum="38A4EA89AF34A9E9" modified="2024-07-24" version="1">METGLLPSQLEGVTILERVCSGFSLFGSMVVIATFCFSKAFHKPINRLVFYATFGNLMTNVATLMARSFIEDQRSAGCQFQAFLIQMFMPADAFWTLAMAVNVYLTFYFKFDAQRLRRMEIPYFLLCYGIPFVVALVLIFVSTPEKGRMYGDATLWCWIAPEWDIFRIAVFYGPVWIVIIITFLIYIRAGREIYKKQKQLRDFSLSTSRHEPETLPPIDDPFSSTKVTEVYVTTEVIDKNDTINLAPLGGSASDGRKSQPSASPQKPAKAAYSVTISSNRPEGAPSEMEGQVQTTITADPRAATAGGTGLGRTITNTNTSKVVSSGGGTHSGTGNGNHLRRRAAYEANNATWSYAKCAILFFTAMLVTWLPSSANRVYSVIHPGGASLALEYMSSFVLPLQGFWNAIIYIVTSWAACKIVWDDIKSWWSCTTSSSHRRRRANSRGLPGSHDLMPGGGGKVGLHMHRSAFQMMGGSKSSDSKAYETESMTELAGSRPGSSGHSGTSTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GYQ6</accession>
    <name>A0AAJ0GYQ6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ferritin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_111299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724354.1">
        <property type="nucleotide sequence ID" value="XM_062861507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GYQ6"/>
    <dbReference type="GeneID" id="87880336"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00657">
        <property type="entry name" value="Ferritin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052965">
        <property type="entry name" value="Pigment-catalase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31694">
        <property type="entry name" value="DESICCATION-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31694:SF8">
        <property type="entry name" value="STRESS RESPONSE PROTEIN RDS1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13668">
        <property type="entry name" value="Ferritin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042550447" evidence="1">
        <location>
            <begin position="22"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3308574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="320" mass="32777" checksum="060555F2AFDA0884" modified="2024-07-24" version="1">MPSIRTTLGAVVAGLAAVSSAVPGIPKLNKAQVQMYEHAKRQNEAAAAAGLTDVDILQFALTLEWLEATFYQQGFAKFPATDFQALGLTQQEIDDLLKIGKTEEEHVILLQSAIAQAGVQPVQPCTYNFAFTDAAGMVATAAVLENVGVSAYLGAASLVSDGSILTTAGSILTVEARHQTFIRAASKALAVPQAFDTPLTPKQVFSLAAPFIQSCPDGSNLILTAFPTLAMAAGQSTTAVAAGTTIQLQSDAAATATNCAFTTGGIPGGTVFTPFDPATGCVVPQGLAGITYVNLASAGPLTGKLTDDIIVAGPMVMQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GZ80</accession>
    <name>A0AAJ0GZ80_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_509256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724624.1">
        <property type="nucleotide sequence ID" value="XM_062867772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GZ80"/>
    <dbReference type="GeneID" id="87886601"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027921">
        <property type="entry name" value="NOPCHAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38489">
        <property type="entry name" value="HISTONE CHAPERONE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38489:SF1">
        <property type="entry name" value="HISTONE CHAPERONE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15370">
        <property type="entry name" value="NOPCHAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="275"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="386"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="456"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3308844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="515" mass="56576" checksum="284C2B2BEBEEF57F" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GZG6</accession>
    <name>A0AAJ0GZG6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_392723</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAK3308984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062864653.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87883482"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZIP_Cat8"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C6 transcription factor FacB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
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        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF12">
        <property type="entry name" value="REGULATORY PROTEIN CAT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="10">
        <location>
            <begin position="23"/>
            <end position="53"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3308984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GZU3</accession>
    <name>A0AAJ0GZU3_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
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                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
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            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="EMBL" id="JAUDZG010000002">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724967.1">
        <property type="nucleotide sequence ID" value="XM_062864615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GZU3"/>
    <dbReference type="GeneID" id="87883444"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022793">
        <property type="entry name" value="Rrn10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28054">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28054:SF1">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3309187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="245" mass="26354" checksum="DB9DD54844BE60D2" modified="2024-07-24" version="1">MEAASIGNVSSPDHESAPASPASSASSLTALPGHAKRRRGRDATVYDAVAGRVTLNLSLGDLETPSGRSKRRLSSTADRYSARNLKLAPEEALFRRKNAPVRYAEQDIYWANEDLPNGGLGHLPDGLLLKSVHSYASRFYEAAATRLGSRCYVGTRTIDERSMDETALLAFGVLLEEASREALGKAGDLVFTEPSSEPEAATRVVQEGMSKPASEGAGETRESVTGQSRPKAKRRKVGKQEEFSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GZX5</accession>
    <name>A0AAJ0GZX5_9PEZI</name>
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            <fullName evidence="4">25S rRNA (Uridine(2843)-N(3))-methyltransferase</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">B0T15DRAFT_491485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724720.1">
        <property type="nucleotide sequence ID" value="XM_062866784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GZX5"/>
    <dbReference type="GeneID" id="87885613"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021463">
        <property type="entry name" value="Methyltransf_34"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11312">
        <property type="entry name" value="Methyltransf_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3308940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="399" mass="42926" checksum="D83DC2848D2BC65F" modified="2024-07-24" version="1">MVGKKGAASGGAGSKTKKTNHKASNSNLAKKSQPAVSSVQVGPGEKQMISDEARGQQQRVLNVFRHAFSEVLSLPEFTATLQSVKQALFDRDFAKAFGDPEHLAVYAARWSPTRALCYALVLNGIKEHLEPLCSNPQLDGGGIGDDEALDEENPASTAELQRPQQLRVLSIGGGAAELVAFGAFLNEHASVKSAHLSGSITLLDSGPWTTVVSQLTTALTTAPPLSKYASAAAKLSNTAMLSPSLFTSAFVQHDALTLGKDRLSSLLGATPLLVTILFTLNELFTAGGIGKTTAFLLDLTATVPFGSVLLVVDSPGSYSETSVGKEAKRYPMQWLLDRIMLGTRQEPVNGRRWAKIESHDSVWFRLASEALEYPIPLENMRYQMHLYRAEDATPGDEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H0B8</accession>
    <name>A0AAJ0H0B8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Autophagy-related protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_506201</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725197.1">
        <property type="nucleotide sequence ID" value="XM_062867556.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87886385"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000323">
        <property type="term" value="C:lytic vacuole"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035493">
        <property type="term" value="P:SNARE complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018791">
        <property type="entry name" value="UV_resistance/autophagy_Atg14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157:SF5">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10186">
        <property type="entry name" value="ATG14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="194"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="261"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="199"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="269"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="917"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="935"/>
            <end position="964"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3309417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="997" mass="106847" checksum="65232719207BD43C" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H0N1</accession>
    <name>A0AAJ0H0N1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_9609</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725419.1">
        <property type="nucleotide sequence ID" value="XM_062871492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H0N1"/>
    <dbReference type="GeneID" id="87890321"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF64">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01760)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3309639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="419" mass="46623" checksum="70F658FAD3DFDE2D" modified="2024-07-24" version="1">MLRSRAMIARARTGNQWRRLPQRCQLCTGCGSTPLGSRRRWELVNKRNALLGSCHLSIFYAGASRRGIHIPSILLPPVVFSGLLIALWAWKCVMMVVFQNKIIYMPGLPPNARSERIADWANLCGAIQWTEERTVTGDGKELAMAVTTIPLPQGRPTARPATVKQDNAPAAHVYILYFQGNASSIPPRLPDLSWVLRAVSDSKTHALAPLQLTLVCLSYRGYWTSRGRPSEAGLRLDAEAGVRWVAERHERTFGKHGSTRPILLLWGQSIGSGVATNLASTGRVPSSMPIAGLLLETPFVSVRAMLETLYPQKWLPYKYLWPFLRNHLDSWANLGLIAECTRKKGFPAPMVYILQAERDELVPKEQSEHLYQRCLDLGLPVERGIVPVAYHQQAIARGDGKKLAAQAILKLTMRALDNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H0S5</accession>
    <name>A0AAJ0H0S5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleolar protein 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_497908</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in pre-25S rRNA processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RRM RBM34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725437.1">
        <property type="nucleotide sequence ID" value="XM_062867293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H0S5"/>
    <dbReference type="GeneID" id="87886122"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF25">
        <property type="entry name" value="RNA-BINDING PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="341"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="23"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="461"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="522"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="51"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="522"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="568"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="585"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3309657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="607" mass="66312" checksum="CEB37C57B8D82002" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H1L5</accession>
    <name>A0AAJ0H1L5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,3-glucosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0T15DRAFT_25906</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ALG6/ALG8 glucosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725914.1">
        <property type="nucleotide sequence ID" value="XM_062863298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H1L5"/>
    <dbReference type="GeneID" id="87882127"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042281">
        <property type="term" value="F:dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004856">
        <property type="entry name" value="Glyco_trans_ALG6/ALG8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413">
        <property type="entry name" value="DOLICHYL GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
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                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
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                <person name="Yan M."/>
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                <person name="Ng V."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <person name="Kuo A."/>
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                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
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                <person name="Steindorff A."/>
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                <person name="Natvig D."/>
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                <person name="Ament-Velasquez S.L."/>
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                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <strain evidence="2">CBS 333.67</strain>
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    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Bonometti L."/>
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                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
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                <person name="Chen C."/>
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                <person name="Ohm R."/>
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</entry>
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    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
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                <person name="Ament-Velasquez S.L."/>
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                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
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                <person name="Hiltunen Thoren M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="2"/>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725799.1">
        <property type="nucleotide sequence ID" value="XM_062868299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H1W8"/>
    <dbReference type="GeneID" id="87887128"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01888">
        <property type="entry name" value="eIF2_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03688">
        <property type="entry name" value="eIF2_gamma_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15490">
        <property type="entry name" value="eIF2_gamma_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000009">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000011">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000065">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050543">
        <property type="entry name" value="eIF2G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015256">
        <property type="entry name" value="eIF2g_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044127">
        <property type="entry name" value="eIF2g_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044128">
        <property type="entry name" value="eIF2g_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003077">
        <property type="entry name" value="PRK04000.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854:SF3">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09173">
        <property type="entry name" value="eIF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="81"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3310019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="512" mass="55674" checksum="0C2ACD4E0DFACFAD" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H201</accession>
    <name>A0AAJ0H201_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cation efflux protein transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_481718</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726093.1">
        <property type="nucleotide sequence ID" value="XM_062866046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H201"/>
    <dbReference type="GeneID" id="87884875"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098771">
        <property type="term" value="P:inorganic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1350:FF:000004">
        <property type="entry name" value="Cation diffusion facilitator 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000005">
        <property type="entry name" value="Putative Cation diffusion facilitator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF4">
        <property type="entry name" value="CDF DIVALENT METAL CATION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="7">
        <location>
            <begin position="244"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3310313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="530" mass="58284" checksum="CDA60104328F8805" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H244</accession>
    <name>A0AAJ0H244_9PEZI</name>
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        <recommendedName>
            <fullName evidence="4">Elongin-A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_25546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725905.1">
        <property type="nucleotide sequence ID" value="XM_062863241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H244"/>
    <dbReference type="GeneID" id="87882070"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070449">
        <property type="term" value="C:elongin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010684">
        <property type="entry name" value="RNA_pol_II_trans_fac_SIII_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47543">
        <property type="entry name" value="OS08G0169600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47543:SF2">
        <property type="entry name" value="RNA POLYMERASE II TRANSCRIPTION FACTOR SIII SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06881">
        <property type="entry name" value="Elongin_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="254"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="350"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3310125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="415" mass="45484" checksum="8D8C725E1486D89B" modified="2024-07-24" version="1">MPGPRSLAEMAFRVVMANVSAVSSLPGVPFEYARRVLKAVKSAEHLRLLEVSCESDDLYANEWPEHWKRLIKADFPALSAKHNFVPKDPRSWHKVYQKYKRMDDEMVAAATAKLEQDMAAKAEEENSRRATFLSASQGRKLQPKGRPKGDFRDFAAARPRPPPVKQLSAVQKARQEMAQEAKRFKLATPTGQVKVPAGQLKKAPAAMVEDARRRSQPSLLPPSPKQNAPLPPKPAKAEPRAYVEVLEFSDDEDSGAKDDDLFGDREIEKRPPPPSRPAPQRPSQPLRTGLLSAAPSNKKTQMPPPSSRLPTKSSSAPTHPALTPKVSPTVAPTKRKRASDSAPTPPPRGSPTSLPAPASAPARPKPTGIPSNLEVVDRPPTEANAADLPPQSRVILKRKAKPPTLLLPFKRPRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H2P1</accession>
    <name>A0AAJ0H2P1_9PEZI</name>
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        <recommendedName>
            <fullName evidence="2">WH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_37581</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726204.1">
        <property type="nucleotide sequence ID" value="XM_062864229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H2P1"/>
    <dbReference type="GeneID" id="87883058"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003882">
        <property type="entry name" value="Pistil_extensin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02205">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01218">
        <property type="entry name" value="PSTLEXTENSIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WH2" evidence="2">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="273"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="340"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="383"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3310424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="448" mass="43536" checksum="F19CD93D9760E037" modified="2024-07-24" version="1">MPPPPPPPPPPPPGLGGPPPPPPPPPPSAAAVPGRGALLADITKGKALKKAVTNDRSAPMIGKVSSVGGTAPSGLGAPPIPSLPKTPGGLAPPVPGNRARSNSDQGNRTQPASSIADGPPQLAGLFAGGMPKLRKTGGGVDTGANRDASYLSDSEALPRSAPRPPAAAAPPVPGRPSLPGTASTPSLHPPKKGPPPPVGKKPPPPPPGSRKPSSTVSPPPPPLPGAPAPPPPSVAPPAPSSSAPPAPPPPPPSAAPRPPPAPVRSQPPPPPSASTSSISQSIAAQAAIRAASSVAAPPAAAPPPPPPPPPSGPPRSAAPSPPPSAAPAPPTPPPPPPSAAPAAPAPSALFHSASSASGRASMRSLLDPSNFTLTPNGAGGGSKTPSPGRGSTPTPGSPAVSSGRYVVQDPRWKFHGEEHLPKPREFVGGPRKYRAGRGSSVPLDLGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H2V4</accession>
    <name>A0AAJ0H2V4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RmlC-like cupin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_519531</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pirin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726589.1">
        <property type="nucleotide sequence ID" value="XM_062868438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H2V4"/>
    <dbReference type="GeneID" id="87887267"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02910">
        <property type="entry name" value="cupin_Yhhw_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43212">
        <property type="entry name" value="QUERCETIN 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43212:SF3">
        <property type="entry name" value="QUERCETIN 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin N-terminal" evidence="3">
        <location>
            <begin position="28"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3310809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="294" mass="32395" checksum="CDE12E3F94713AB1" modified="2024-07-24" version="1">MQSALKTVMSNTLHHAKITPHRSAARGHSNHGWLDTYHSFSFANWYNPNFTHFGALRVLNEDRVKPNSGFPTHPHRDFEIFSYILSGELTHTDSTHKQKGGDDAKESELFCRVRRGDIQFTTAGTGVTHSEFNRGREPVHFLQIWAIPWKRGLAPRYDWGRYSDEDKRKGFVSLLSPLKGGVDATAEQEKAAEPTIPGTIAIHADFVMAAGIIESGGKFEWNVGANATAATKRKLYVHLPMTKGGKAKIRLDGREDGILAEGDGAFVDCVNAGDRLVVESVGDAEAEVVVLDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H3A9</accession>
    <name>A0AAJ0H3A9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PITH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_386874</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726500.1">
        <property type="nucleotide sequence ID" value="XM_062864346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H3A9"/>
    <dbReference type="GeneID" id="87883175"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.470">
        <property type="entry name" value="PITH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010400">
        <property type="entry name" value="PITH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037047">
        <property type="entry name" value="PITH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06201">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51532">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PITH" evidence="4">
        <location>
            <begin position="107"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="88"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3310720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="301" mass="33212" checksum="504B702C2DC14B3C" modified="2024-07-24" version="1" fragment="single">YSTTSQPSQQVAPVFEQLSTALSRPNRVTFVSVDTNEQKDVAQAYRITSQPTFIIFRNGKVAERVQGADPTKLQAVVKKLSDEIQSLGTSGAEASGNGSASSSGYWRGAELPRNHTDITDQIELQRCELLNYDPEAGNVRVLFDAAKPSALSGGKGTAKDWVESDTDEQLLLFMPFQSMLKLHTLQVSYVADDDDDEDVPMRPRTIKLFTNKPHNLGFDEAEDLSATQEIQLSEKDWNAEGTANIPLRFVKFQNITSLVVFVVDGDGEGEKTRLDRLRLVGDAGEKREMGKLEKIGDEPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H3K1</accession>
    <name>A0AAJ0H3K1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ER protein Pkr1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_64087</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726936.1">
        <property type="nucleotide sequence ID" value="XM_062871147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H3K1"/>
    <dbReference type="GeneID" id="87889976"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013945">
        <property type="entry name" value="Pkr1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3311156.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
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                <person name="Steindorff A."/>
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                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062871224.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87890053"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
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    </dbReference>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3311304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="382" mass="41464" checksum="3C76CF18C59783B7" modified="2024-07-24" version="1">MSGTFFTSWELWQQMTFVLAMAIVAVFCAGLGKLWWNNRLVKKQEVLDEEKRARVEEMRKTGLPIKRTNNIPFGVRAIQSGVEVDGIWISRPASLNETASAKLTSSTSIAGRDSDSQKKRRDHPGNEKKAVLVTTTSLGDKRTPSAAAVSQKLTDHDPTQRPQSGAPPLSRFAYKARRQPSRPAGGLDQNTLQRLEGQPAEQPLYETYVPASSSRQEPRQPSQRSWESSSRESVDSQSRSTSGRSYSSSSHSSRFYMARTTQGVRAGHDPPLGRCSEAEAASDPFATPARTPSGFSLLSQVDTPGPGAQGQGVSAPEPTFGPGDLHLNLNRSSRRVNDGFEILPAGALGMPRGMAKLEESEQNGQASGSSARLRKSGGWPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
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                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062871115.1"/>
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    <dbReference type="GeneID" id="87889944"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056119">
        <property type="entry name" value="DUF7702"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109:SF2">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109">
        <property type="entry name" value="UNPLACED GENOMIC SCAFFOLD UM_SCAF_CONTIG_1.265, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7702" evidence="2">
        <location>
            <begin position="6"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3311054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="268" mass="29660" checksum="80748DC9FBF8BD4D" modified="2024-07-24" version="1">MVVNPHTAAAIAQVVLYVPMVPLALYLLARNWRYRPRTAWYPPAVFSTVRLVGGIVTIIEQQNQRNRGLIIATIILLNLGLIPLILAYLGYARLVLEHHFADNRRLNILLRLIKIGVLVAAGFLGTAGGYAGQPEHADAQSKLSRAAYTIFALALVVLIASFIRLFLNLSQITPAHRTYVRWALVAAVPLCVRAAYGIIGVVVASGTNILTSDWSPLFGSATAFGLMALLPEYIVLSIYIFLSIYHLRTNKQEELIEERIKLESRDMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H4E3</accession>
    <name>A0AAJ0H4E3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ethanolamine kinase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_409040</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
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            <taxon>Pezizomycotina</taxon>
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        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the choline/ethanolamine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.82" evidence="3"/>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727100.1">
        <property type="nucleotide sequence ID" value="XM_062865345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H4E3"/>
    <dbReference type="GeneID" id="87884174"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004305">
        <property type="term" value="F:ethanolamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05157">
        <property type="entry name" value="ETNK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603">
        <property type="entry name" value="CHOLINE/ETHANOALAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603:SF66">
        <property type="entry name" value="ETHANOLAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01633">
        <property type="entry name" value="Choline_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3311320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="435" mass="49021" checksum="DAA41F95E0D35C46" modified="2024-07-24" version="1">MVISGENGIHRNGEVNGDKHRIRYIPLSYDSANSQESALQLVLSIRPDWKLPGSNVEFVRFTDGITNTLLKAVNKRPELSKDAIDREAILLRAYGHGTDLIIDRHRETQNHELLTRYGLAPELLARFENGMMYRFIRGVVTHPDDLRKADIYKAVARRLAEWHAVVPCITGHTGHSRKNSKVDGLSNPALDGNFGDAEFQQAIDSVAPGKPPPNVWTVMQKWIFALPTDTEAQRARQAALQQELKTLVSELSQRPGLGVNGLVFAHCDLLSGNVIVLPKTEKSAETTVTFIDYEYATPSPAAFDIANHFAEWGGFDCDFSVLPTRAQRREFITEYVDSYLKFLEKKRPGAAAAVDKAAEVEKLLAEVDHFRGVPGFYWGIWALIQATISQIEFDYSSYAETRLGEYYAWRDEVTGERAKSGKEMPLRERRWAQDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LXT4</accession>
    <name>A0AAJ0LXT4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_317595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717404.1">
        <property type="nucleotide sequence ID" value="XM_062864018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LXT4"/>
    <dbReference type="GeneID" id="87882847"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1230.10:FF:000005">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone]alpha subcomplex assembly factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1230.10">
        <property type="entry name" value="MTH938-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036748">
        <property type="entry name" value="MTH938-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007523">
        <property type="entry name" value="NDUFAF3/AAMDC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21192:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21192">
        <property type="entry name" value="NUCLEAR PROTEIN E3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04430">
        <property type="entry name" value="DUF498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64076">
        <property type="entry name" value="MTH938-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3301624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="264" mass="28698" checksum="71D6621E0F278898" modified="2024-07-24" version="1">MSTPSPALRVPLTTCRILRSNTTKCVPRRQPPYLRVQTPLLRLPSTTTITTTACCNNNNNNNNNNNNSNRDAPVPSYHRAVHTSPPTDRQRKQLAHNREEVPDQPPPTDFGQMDLLGSTPVPSTAVTACHEDGFSLDSGIHITGGDGALLVGGEAFAWRPWSSTSTPKGGRKLVNDKGQWEVVEEGFALLGVVWPRPDLLILGLGPEMRPLSPATRRTISNLGMNVEVLDTRNAANQYNMLATERGVDNVAAALIPIGWKEGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LYG7</accession>
    <name>A0AAJ0LYG7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phosphatase 2C-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_300864</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718095.1">
        <property type="nucleotide sequence ID" value="XM_062863811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LYG7"/>
    <dbReference type="GeneID" id="87882640"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000078">
        <property type="entry name" value="Protein phosphatase 2C, putative"/>
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    </dbReference>
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        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PP2C"/>
    </dbReference>
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        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF837">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="126"/>
            <end position="462"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="515"/>
            <end position="574"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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            <end position="35"/>
        </location>
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        </location>
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            <begin position="70"/>
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        </location>
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            <begin position="543"/>
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
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            <begin position="563"/>
            <end position="574"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3302315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="3">Heterokaryon incompatibility protein-domain-containing protein</fullName>
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    </gene>
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        <lineage>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF12">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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    </dbReference>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3302885.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3302959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718739.1">
        <property type="nucleotide sequence ID" value="XM_062863313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZ27"/>
    <dbReference type="GeneID" id="87882142"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3302959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="204" mass="21142" checksum="27DD6290FEF936CA" modified="2024-07-24" version="1">MVTFPKAARFENPRQSYWRPSSPSRPETGPTHTIAPPTRSNRRRTPASAAAPAAQRAARATTSVTSPAPAGSSTPQSPIAQSRRPSQHGPLAAQIVAPATDGAQEGSRNQLARASPKSDDLPSPSVAPSRARSTATSSTSSSSRPPSPPSSPPTPPGGPVPPTGAGFDAPDSDNETVLKICRSRMTGGETVFVRPRGRKPLELC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZ59</accession>
    <name>A0AAJ0LZ59_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase M20 dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_263245</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718871.1">
        <property type="nucleotide sequence ID" value="XM_062863365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZ59"/>
    <dbReference type="GeneID" id="87882194"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05652">
        <property type="entry name" value="M20_ArgE_DapE-like_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050072">
        <property type="entry name" value="Peptidase_M20A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43808">
        <property type="entry name" value="ACETYLORNITHINE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43808:SF30">
        <property type="entry name" value="ACETYLORNITHINE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042481549" description="Peptidase M20 dimerisation domain-containing protein" evidence="6">
        <location>
            <begin position="21"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="7">
        <location>
            <begin position="254"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3303091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="444" mass="47648" checksum="10F6F432CAC36918" modified="2024-07-24" version="1">MRITVRSLLLCSTLCARVSAHWAADSKQQPIVHHQGPLGDNNDDDEKTPVYRTSLLSLHRALVDVPSISGSERSVAILLEKILTDYNYTVELQRLSSTKPSSDENDESHARYNVLAWPGRNSDRTFHNRVLITSHIDVVPPYIPYAINGTPIAPGSPYDFSDITSNTFISGRGSVDAKGSVAAQITAASLLWSSPSIHASDVMLLFVVGEETSGQGMKFFSSSLSNHTSPPGGQRPQFRAVIFGEPTENKLACGHKGILGGSIFAKGKAGHSGYPWLGKSAISVLVRALDKLLSADLGSSERYGNTTVNVGFIEGGVAANVIAKEAKARLAVRIAVGNQTTGGEIVAEGIRKVLRETDEEALGLELVAGYGPVECNCEVEGFETMVANYGTDVPNLHGDHVRYLYGPGSILVAHGDDEGLRVRDLEDAVEGYKRLIKHAVEDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZ64</accession>
    <name>A0AAJ0LZ64_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_402368</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3302988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718768.1">
        <property type="nucleotide sequence ID" value="XM_062865158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZ64"/>
    <dbReference type="GeneID" id="87883987"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF92">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="27"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="271"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="299"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3302988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="346" mass="37288" checksum="E5065626F9088405" modified="2024-07-24" version="1">MASDDNGPPMTITMVVCTVASFCFMSLRFYCKQALGTKVGIDDAILAFSWLLFLVFVIISIYCTKLGLGKHVSDLTDMTLLPQLLYLLPIGQFFAVLSVAVSKSSFIITLLRLVTQPWQKAALWFMLATINASMLSISIVQFFQCAVPPTPGCVAGDHVIGLGVFAAGYSAVMDLVLTAFPTVVIWNLQMKKREKIGVIASMSLGVVAGVVGIYKSSTIPAVSRNVDFTHGTAIVLIWLVAEVTATVIAASIPFYRPLVRRVSRTGNSKGSYAMGGMGGRSGHSKLGSSADVKGAPAYGDDHDSDRDIKPLNSHTVRRTDAYTVEYDNMSSTEAGTNKPTGRREMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZG7</accession>
    <name>A0AAJ0LZG7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_272227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719145.1">
        <property type="nucleotide sequence ID" value="XM_062863479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZG7"/>
    <dbReference type="GeneID" id="87882308"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3303365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="158" mass="18284" checksum="66E2FDE5E5BF1674" modified="2024-07-24" version="1">MNNFWSDDRHAVTVALHRRNAYNDKRTERGATYVTSFPFRIAWCGMTRLKWIKQNGSWPKGSEVAWSAMEHGKTRQNGRVPEQPGTLMYLTKTGCVFPFSILFPLSSIDDRTDTVVMSHGMAYCLLVFFYLAWSSLHSRLENKQHARDAIFCYFSNVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZY3</accession>
    <name>A0AAJ0LZY3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uracil phosphoribosyltransferase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_398808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3303901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719681.1">
        <property type="nucleotide sequence ID" value="XM_062864972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZY3"/>
    <dbReference type="GeneID" id="87883801"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036424">
        <property type="term" value="F:L-phosphoserine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050582">
        <property type="entry name" value="HAD-like_SerB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43344">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43344:SF20">
        <property type="entry name" value="URACIL PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13207">
        <property type="entry name" value="AAA_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12710">
        <property type="entry name" value="HAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="1">
        <location>
            <begin position="475"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3303901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="675" mass="74746" checksum="9A9E454617FAA3F1" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M078</accession>
    <name>A0AAJ0M078_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_568151</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719967.1">
        <property type="nucleotide sequence ID" value="XM_062870748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M078"/>
    <dbReference type="GeneID" id="87889577"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF5">
        <property type="entry name" value="MEIOSIS-SPECIFIC APC_C ACTIVATOR PROTEIN AMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="747"/>
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                <person name="Grigoriev I.V."/>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720236.1">
        <property type="nucleotide sequence ID" value="XM_062863076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M0G9"/>
    <dbReference type="GeneID" id="87881905"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051701">
        <property type="entry name" value="Mito_OM_Translocase_MSP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644:SF56">
        <property type="entry name" value="AAA ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644">
        <property type="entry name" value="AAA ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12920)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="767"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="46"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="685"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="688"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3304456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1043" mass="114435" checksum="E3CFF86B1692288A" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M173</accession>
    <name>A0AAJ0M173_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_433906</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721020.1">
        <property type="nucleotide sequence ID" value="XM_062865786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M173"/>
    <dbReference type="GeneID" id="87884615"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF167">
        <property type="entry name" value="FI17812P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="10">
        <location>
            <begin position="95"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="9">
        <location>
            <begin position="557"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3305240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="761" mass="84762" checksum="BCEB43FB217A03D3" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M1G1</accession>
    <name>A0AAJ0M1G1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_532468</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. MAK3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721275.1">
        <property type="nucleotide sequence ID" value="XM_062869313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M1G1"/>
    <dbReference type="GeneID" id="87888142"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004596">
        <property type="term" value="F:protein-N-terminal amino-acid acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044542">
        <property type="entry name" value="NAA30-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45896">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45896:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="13"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3305495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="208" mass="23352" checksum="AC908B12779238C7" modified="2024-07-24" version="1">MESAPNPELPGELRYIQYQHSLEAQYLPAIRALISKDLSEPYSIYVYRYFLYQWGHLCFMALTPADSSLIGVIVCKLESHTSHSPQTLRGYIAMLAVSAPHRGHGVATALVKMAIDAMAQRNADEIVLETEETNIPAMRLYERLGFLRAKKLHRYYLNGNSAYRLVLLLKPTDIDAATDLALDEDDVAPQEGYTWSLEMESNQGPCAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M1H8</accession>
    <name>A0AAJ0M1H8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_555709</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721272.1">
        <property type="nucleotide sequence ID" value="XM_062870399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M1H8"/>
    <dbReference type="GeneID" id="87889228"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00364">
        <property type="entry name" value="Ribosomal_uS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_uS17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US17M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="95"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3305492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="177" mass="19518" checksum="76670EB60F26F68B" modified="2024-07-24" version="1">MAQPAAQAAKSAFRKFRELHGVVISAGLMDKTVKVRVGGQKWNSFVKKFFDDPKTHLVHDPNNSLRLGDVVAITPGWRVSKSKRHVVKHIIAPGSGVPIDGRPPIPTEEERYAEKDAKRAAKDERRSMKRMAERVEAQLGVAEMLLRRARKEFALRARLMGASVDGGQLGTGAGTQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M1K9</accession>
    <name>A0AAJ0M1K9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein-ribulosamine 3-kinase</fullName>
            <ecNumber evidence="1">2.7.1.172</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_434584</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>N(6)-D-ribulosyl-L-lysyl-[protein] + ATP = N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48432"/>
            <dbReference type="Rhea" id="RHEA-COMP:12103"/>
            <dbReference type="Rhea" id="RHEA-COMP:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:90418"/>
            <dbReference type="ChEBI" id="CHEBI:90420"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.172"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:48433"/>
        </physiologicalReaction>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.172" evidence="1"/>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721362.1">
        <property type="nucleotide sequence ID" value="XM_062865801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M1K9"/>
    <dbReference type="GeneID" id="87884630"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102193">
        <property type="term" value="F:protein-ribulosamine 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016477">
        <property type="entry name" value="Fructo-/Ketosamine-3-kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149">
        <property type="entry name" value="FRUCTOSAMINE 3 KINASE-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149:SF8">
        <property type="entry name" value="PROTEIN-RIBULOSAMINE 3-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03881">
        <property type="entry name" value="Fructosamin_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00048655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3305582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="427" mass="48981" checksum="4A53A59AF153E743" modified="2024-07-24" version="1">MSLWGKTGKITAELPDGQLKNYFLKTASLGDTGRAMMFGEYESLKAIRAVSPAIVPEPYAWGKYDGSGTYFLVAEYREVGEQPPNPIRFTKRLAEMHKKSLSPTGKFRFHVTTCHAKLPQITDCWEDSWAVLYRKQLAHMINLDEQKHSEWPEFKIACQLVLDKVIPRLLEPLQSDGRSITPYLVHGDLWDENTATDMATGEPFTFDAGSFYGHNEYEIGNWRAARHRLSAQPYVKGYLREFPASHPEEEWDDRNLLYSLRFDLGTAILIHCNQRQIVKENMAILCNKFFPNEYAALKNSLTGQPLRANPGLRGAVTYTEEAEKRKRTRHSGRKVTKTMKTTNCRISMAWTLTMSGTTTLLSSTRTGGAKWNSICKLLRCLCRCLDHFLFLYHRRLYFRILLGKASQDHMAHLSALHINPVCRRDIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M1P3</accession>
    <name>A0AAJ0M1P3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CP2 transcription factor-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_207779</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721515.1">
        <property type="nucleotide sequence ID" value="XM_062862636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M1P3"/>
    <dbReference type="GeneID" id="87881465"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007604">
        <property type="entry name" value="CP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057520">
        <property type="entry name" value="GRHL1/CP2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040167">
        <property type="entry name" value="TF_CP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11037:SF20">
        <property type="entry name" value="PROTEIN GRAINYHEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11037">
        <property type="entry name" value="TRANSCRIPTION FACTOR CP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04516">
        <property type="entry name" value="CP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25416">
        <property type="entry name" value="GRHL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51968">
        <property type="entry name" value="GRH_CP2_DB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Grh/CP2 DB" evidence="7">
        <location>
            <begin position="248"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="27"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="472"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="554"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="55"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="570"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="592"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="626"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3305735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="797" mass="87246" checksum="2F157C43BEAE266E" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M1Y5</accession>
    <name>A0AAJ0M1Y5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">DNA replication complex GINS protein PSF3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_511778</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The GINS complex plays an essential role in the initiation of DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the GINS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GINS3/PSF3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721693.1">
        <property type="nucleotide sequence ID" value="XM_062867935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M1Y5"/>
    <dbReference type="GeneID" id="87886764"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11713">
        <property type="entry name" value="GINS_A_psf3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21693">
        <property type="entry name" value="GINS_B_Psf3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010492">
        <property type="entry name" value="GINS_Psf3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038437">
        <property type="entry name" value="GINS_Psf3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055221">
        <property type="entry name" value="PSF3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22768">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22768:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22466">
        <property type="entry name" value="PSF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160059">
        <property type="entry name" value="PriA/YqbF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication complex GINS protein PSF3 N-terminal" evidence="9">
        <location>
            <begin position="4"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="GINS subunit" evidence="8">
        <location>
            <begin position="78"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3305913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="197" mass="21598" checksum="AADB5F3C685424E7" modified="2024-07-24" version="1">MSYYDIDSILTDAEKIPCTFQLDVPDLGYLDNTPTQPLKVGTRVNLPLWLAEMLVIANSGDIEGRPFVTFDLPPALGNDVVQALKADPRAVPLRDQSPHFYGLAARLMELLDEKELATVLRKTFVVRASEIALHARKVGGPGHHKGKNPAEEGSNLGIGGAGEDFLRGLDESERGLFRKAHDGAKSGKEWMESIKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M270</accession>
    <name>A0AAJ0M270_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_551914</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722052.1">
        <property type="nucleotide sequence ID" value="XM_062870281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M270"/>
    <dbReference type="GeneID" id="87889110"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3306272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="251" mass="27721" checksum="9EF8766A152CC915" modified="2024-07-24" version="1">MSDEARASVDDDLRRVSSRLPAAFVGYRLFPPVLNLYGNPSGILDALNTFKLCGAAKNDLLYLVDVHHGFTPRGPLHFRPGLYLRNGTSTDAPILAAAGDEAREPLLIATFSVKSYIMLLPLDLEANPCDLITEIMYAIKTSDGAVSFRFTIEVGPKMKCREQFEWRKSASPSLIPPAQEETEILAELLFRNVMSLNHLFSLELKGAGSSGEMGDRWALMVVVTALRLYWLCTYGKTNKLVVGIGQKLRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M2A5</accession>
    <name>A0AAJ0M2A5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_137313</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722098.1">
        <property type="nucleotide sequence ID" value="XM_062861832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M2A5"/>
    <dbReference type="GeneID" id="87880661"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3306318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="64" mass="6902" checksum="340CDB3DF51EB70B" modified="2024-07-24" version="1">MGFQSGDVVRLRGSTVVYKVVAVNGCLVTILVSNPQPDGQYLPFNSTSLQTVDESRLEKADDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M2I4</accession>
    <name>A0AAJ0M2I4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_394220</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722397.1">
        <property type="nucleotide sequence ID" value="XM_062864719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M2I4"/>
    <dbReference type="GeneID" id="87883548"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23043">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23043:SF17">
        <property type="entry name" value="PROTEIN SIMILAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="17"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="167"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="229"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="591"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="260"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="592"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="605"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3306617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="630" mass="69599" checksum="15E399F12AFA5C49" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M2M3</accession>
    <name>A0AAJ0M2M3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_492266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722517.1">
        <property type="nucleotide sequence ID" value="XM_062866850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M2M3"/>
    <dbReference type="GeneID" id="87885679"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3306737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="92" mass="9376" checksum="B156E088E374DBE0" modified="2024-07-24" version="1">MSSGNNNGHSSKNWDEVLKHGSALSIIKPDVAFPYGGSSSSGSTSGSTSGGASGGSSYPSGGSALRTRLETCTLKEDKVKVFKERAKLAHGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M2Z9</accession>
    <name>A0AAJ0M2Z9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_553623</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722940.1">
        <property type="nucleotide sequence ID" value="XM_062870327.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87889156"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF37">
        <property type="entry name" value="SI:DKEY-61P9.11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22621">
        <property type="entry name" value="CurL-like_PKS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="8">
        <location>
            <begin position="380"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="9">
        <location>
            <begin position="1326"/>
            <end position="1651"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="1699"/>
            <end position="1774"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="1822"/>
            <end position="1896"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="5">
        <location>
            <begin position="1326"/>
            <end position="1464"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="5">
        <location>
            <begin position="1493"/>
            <end position="1651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1665"/>
            <end position="1696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1784"/>
            <end position="1824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1787"/>
            <end position="1824"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="5">
        <location>
            <position position="1361"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="5">
        <location>
            <position position="1557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3307160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="2266" mass="241894" checksum="D56A5F94AAB7F0D0" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M3B5</accession>
    <name>A0AAJ0M3B5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Clr5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_493005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723311.1">
        <property type="nucleotide sequence ID" value="XM_062866905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M3B5"/>
    <dbReference type="GeneID" id="87885734"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025676">
        <property type="entry name" value="Clr5_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14420">
        <property type="entry name" value="Clr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clr5" evidence="2">
        <location>
            <begin position="17"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3307531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="567" mass="62566" checksum="5A49B5ED2650C084" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M3E2</accession>
    <name>A0AAJ0M3E2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">5-formyltetrahydrofolate cyclo-ligase</fullName>
            <ecNumber evidence="5">6.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_394581</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(6S)-5-formyl-5,6,7,8-tetrahydrofolate + ATP = (6R)-5,10-methenyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10488"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.2" evidence="5"/>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723268.1">
        <property type="nucleotide sequence ID" value="XM_062864733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M3E2"/>
    <dbReference type="GeneID" id="87883562"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030272">
        <property type="term" value="F:5-formyltetrahydrofolate cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009396">
        <property type="term" value="P:folic acid-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002698">
        <property type="entry name" value="FTHF_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407:SF1">
        <property type="entry name" value="5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407">
        <property type="entry name" value="ATPASE INHIBITOR/5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01812">
        <property type="entry name" value="5-FTHF_cyc-lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006806">
        <property type="entry name" value="FTHF_cligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="8"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="167"/>
            <end position="175"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00036539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3307488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="245" mass="26111" checksum="8EA45DC7933363A0" modified="2024-07-24" version="1">MASLNAAKRHLRAAMKVKLQAVSQDSVVSQSSTVYSTLKTVKGYVGAKRISVFLSMPTGEIQTDAIVRDALAAGKEVFIPYLHKNPVEGPGLPARVMDMVRLRDLADYESLQPDKWGIPSVDPATVPARQRVFGGADAPHSDSTLLDLVLMPGVAFDTDPANGAVRRLGHGKGFYDYFLFRHRLKAGSLGKQESPVLLLGLALSEQFLSPSEGAVPVGPLDQPLDGLILGDGTVRGPLAPANTTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M3F6</accession>
    <name>A0AAJ0M3F6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4'-phosphopantetheinyl transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_181636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723313.1">
        <property type="nucleotide sequence ID" value="XM_062862318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M3F6"/>
    <dbReference type="GeneID" id="87881147"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="entry name" value="4'-phosphopantetheinyl transferase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="4'-phosphopantetheinyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3307533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="254" mass="28122" checksum="1BB1E7F90AD66B53" modified="2024-07-24" version="1">MPPPLPFPYPLRIGTDLCRISRIQRILQGKNGPRFIHRVLAPEELVHVRPVMRAVLDDAVRGSVAKAAAGSAGGTGVRRPISPTTRERELWGREWEGGGKLEVPEEEQHRHDESYLQGERKRDGLSGEEGEEGGFGLYKSAATFLAGRWAAKEAAFKAHPHLRLGFHDVLILSPAEMEAQTGDQPLQQQAWQAKGAPVAVIKPGEGRRDQIAMVSITHDGNYASAVCIGFESGQEGREREQRSGWFPRLSRLWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M3G2</accession>
    <name>A0AAJ0M3G2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cell wall protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_185404</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723446.1">
        <property type="nucleotide sequence ID" value="XM_062862368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M3G2"/>
    <dbReference type="GeneID" id="87881197"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042463553" description="Cell wall protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3307666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="326" mass="32593" checksum="F440CF4E085F408F" modified="2024-07-24" version="1">MRGITNSLVRLLALLLLVALAAAQSSSAAPLTTTSLPAPTAPPPPSSSSSPSTSPSSTGNGNGSSSLPPSSSVPPVPTGTSPSSTSPPDVLLRVPELHVGRIELDVDDLRADLNLNAEIARLVSLNVGVQVAVSKVNITIADVDAELDLVIRLGNLARMVNRTLASLDLNPLLVNVLNDVGEIVGGVVGAVDGLLGSIVGGGGGGEEVRFLIDNLGNIVQEVVAGGGGVVSSIVGNYEKNMTFTGAVKEVGNGLTQKTYRYDPLGSLVNIIFNTLGQVVQAVVIGKDHSGGGSTGTSSSSVVPTSTASVSTTASSATQAASTTSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M4A9</accession>
    <name>A0AAJ0M4A9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha N-terminal protein methyltransferase 1</fullName>
            <ecNumber evidence="5">2.1.1.244</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">X-Pro-Lys N-terminal protein methyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0T15DRAFT_509003</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54712"/>
            <dbReference type="Rhea" id="RHEA-COMP:13785"/>
            <dbReference type="Rhea" id="RHEA-COMP:13971"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138057"/>
            <dbReference type="ChEBI" id="CHEBI:138315"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-methionine = N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54736"/>
            <dbReference type="Rhea" id="RHEA-COMP:13787"/>
            <dbReference type="Rhea" id="RHEA-COMP:13974"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138059"/>
            <dbReference type="ChEBI" id="CHEBI:138318"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54724"/>
            <dbReference type="Rhea" id="RHEA-COMP:13789"/>
            <dbReference type="Rhea" id="RHEA-COMP:13973"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138061"/>
            <dbReference type="ChEBI" id="CHEBI:138317"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. NTM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.244" evidence="5"/>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724331.1">
        <property type="nucleotide sequence ID" value="XM_062867763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M4A9"/>
    <dbReference type="GeneID" id="87886592"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071885">
        <property type="term" value="F:N-terminal protein N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008576">
        <property type="entry name" value="MeTrfase_NTM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12753">
        <property type="entry name" value="AD-003 - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12753:SF0">
        <property type="entry name" value="ALPHA N-TERMINAL PROTEIN METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05891">
        <property type="entry name" value="Methyltransf_PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016958">
        <property type="entry name" value="DUF858_MeTrfase_lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR016958-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3308551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="238" mass="25890" checksum="78FAE95D320D6E4F" modified="2024-07-24" version="1">MAEGNDARNGNVDSLISREHGRKYWEATEANVDGMLGGLPHTDHISRVDIRGSRNFLAKLGIGAKPGQRVAASALEGGAGIGRVTQGLLLDGIAKQVDVIEPIAKFTAAMQGKPGVRSVFNVGLEDWQPTEGAQYDLVWIQWCVVHLTDEQLVEFLKRCKSALNPDGGLIVVKENNSTGGKDEFDDIDSSVTREDGTFRRIFTEAGLRLVQVELQRGLQARGMPALLPVRMYALKPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M4L3</accession>
    <name>A0AAJ0M4L3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_525549</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724646.1">
        <property type="nucleotide sequence ID" value="XM_062868850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M4L3"/>
    <dbReference type="GeneID" id="87887679"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029164">
        <property type="entry name" value="PIG-Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39400:SF1">
        <property type="entry name" value="PIG-P DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39400">
        <property type="entry name" value="YALI0E29227P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15159">
        <property type="entry name" value="PIG-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="354"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="399"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="214"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="267"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3308866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="436" mass="46539" checksum="B214E4FEA00EE585" modified="2024-07-24" version="1">MEQPTPLMGPGPNGLAPAPNRPPAPARKRSSSGAGGLLSKFPFMRSVGEHRPRSRRNTIESEPGGQAPSLPTPSFVTIPAEEPQRQVAAAGAAPPALPHINQLQSLLSPQQQKTRRRRGSLRKVALLGRGAQRERRDSRSSTIDPQLEVNGANGRPAESAVSGAAALTSSPVQIDGSPREIPMRKNSGGDPLPLGLGISDLTPRPSMDGYAIRSDTSTPDPVTPTAAPAPRKCVPESSPSINYSTTDDEDALHMARRNGPITVSNQTPSTLSLSSTASLVRPERASVSSGSESYYLGPPHARPPGTGNGGLPSIQRRRSVNQRAKSPLALSSLAAPLSPPDADWDYAETEWWGWIILVVTWFVFVVGMGSCLGVWSWAWDVGTTPYAPPELEDDPTLPIVGYYPALMILTGVMAWVWVVVAWVGMKYFRHAQVSGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M4Z2</accession>
    <name>A0AAJ0M4Z2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Inositol oxygenase</fullName>
            <ecNumber evidence="4 14">1.13.99.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 14">Myo-inositol oxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0T15DRAFT_491755</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 14">
            <text>myo-inositol + O2 = D-glucuronate + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23696"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:58720"/>
            <dbReference type="EC" id="1.13.99.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="13 14">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Polyol metabolism; myo-inositol degradation into D-glucuronate; D-glucuronate from myo-inositol: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the myo-inositol oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.99.1" evidence="4 14"/>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3309228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725008.1">
        <property type="nucleotide sequence ID" value="XM_062866807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M4Z2"/>
    <dbReference type="GeneID" id="87885636"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050113">
        <property type="term" value="F:inositol oxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019310">
        <property type="term" value="P:inositol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007828">
        <property type="entry name" value="Inositol_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12588:SF0">
        <property type="entry name" value="INOSITOL OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12588">
        <property type="entry name" value="MYOINOSITOL OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05153">
        <property type="entry name" value="MIOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="109"/>
            <end position="111"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="167"/>
            <end position="168"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="244"/>
            <end position="245"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR607828-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR607828-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3309228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="310" mass="35745" checksum="E264B796336E2D0D" modified="2024-07-24" version="1">MAAVAVHAAPVHRNGAELEAISDAVDTVNILKDGPSFDTESHFDADKDKSAFRQYEDACDRVKSFYAEQHAKQTVAHNVAARERFYSPTRQRAEMSIWEAMEKLNTLIDDSDPDTELSQIHHLLQSAEAIRRDGKPRWMQLTGLIHDLGKLMLFFDDCCEGQWDVVGDTFPVGCRFDERCIYPDTFAANPDSRHDVYSTRYGIYAPGCGMDKLMMSWGHDEYLYHVVKDQSMLPREALAMIRFHSFYPWHKEGAYREFMADGDEVLLNAVKAFNPYDLYSKSDDVPNVEELKPYYLELIDEFFPQKVIKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M509</accession>
    <name>A0AAJ0M509_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_515176</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725082.1">
        <property type="nucleotide sequence ID" value="XM_062868167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M509"/>
    <dbReference type="GeneID" id="87886996"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="18"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="49"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="165"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="303"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="425"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="485"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="425"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="499"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3309302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="571" mass="60104" checksum="DEFAB2153CD5BC44" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M5I5</accession>
    <name>A0AAJ0M5I5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="1">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_515849</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the E3 ubiquitin-protein ligase UBR1-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="1"/>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725352.1">
        <property type="nucleotide sequence ID" value="XM_062868222.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87887051"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071596">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the N-end rule pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16482">
        <property type="entry name" value="RING-H2_UBR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2670">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042065">
        <property type="entry name" value="E3_ELL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044046">
        <property type="entry name" value="E3_ligase_UBR-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039164">
        <property type="entry name" value="UBR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055194">
        <property type="entry name" value="UBR1-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497:SF24">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497">
        <property type="entry name" value="UBIQUITIN LIGASE E3 ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18995">
        <property type="entry name" value="PRT6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22960">
        <property type="entry name" value="WHD_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="E3 ubiquitin-protein ligase UBR1-like winged-helix" evidence="4">
        <location>
            <begin position="846"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="domain" description="E3 ubiquitin-protein ligase UBR-like C-terminal" evidence="3">
        <location>
            <begin position="1448"/>
            <end position="1934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="221"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="285"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1094"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="229"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="249"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="290"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3309572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1957" mass="222525" checksum="6697976ADEF248FF" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M6R8</accession>
    <name>A0AAJ0M6R8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_507752</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726941.1">
        <property type="nucleotide sequence ID" value="XM_062867666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M6R8"/>
    <dbReference type="GeneID" id="87886495"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044695">
        <property type="term" value="C:Dsc E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050731">
        <property type="entry name" value="HRD1_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763">
        <property type="entry name" value="RING ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763:SF162">
        <property type="entry name" value="TRANSMEMBRANE E3 UBIQUITIN-PROTEIN LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="514"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="405"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="638"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="822"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="214"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="267"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="333"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="424"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="438"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="638"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="659"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="692"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3311161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="852" mass="91947" checksum="EF1C81A4D8CCF9D6" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M6Y5</accession>
    <name>A0AAJ0M6Y5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-splicing factor PRP46</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Pre-mRNA-processing protein 46</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_66129</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Involved in pre-mRNA splicing and required for cell cycle progression at G2/M.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 8">Belongs to the WD repeat PRL1/PRL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726974.1">
        <property type="nucleotide sequence ID" value="XM_062871166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M6Y5"/>
    <dbReference type="GeneID" id="87889995"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000012">
        <property type="entry name" value="Putative pleiotropic regulator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045241">
        <property type="entry name" value="Prp46/PLRG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19923:SF0">
        <property type="entry name" value="PLEIOTROPIC REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19923">
        <property type="entry name" value="WD40 REPEAT PROTEINPRL1/PRL2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="1 7 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="185"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="227"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="269"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="311"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="394"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00056150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU369036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3311194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="498" mass="54453" checksum="68F8A9796A263E15" modified="2024-07-24" version="1">MMAAEVASNGADVSRLEALVRDNARRTKSIYTSTAPDSSARKRIKLDPGLASEDPDITKTALSLRLHAEYNDVQTLPEVIAKKLPAAGPRKKKPKAAEEAPSKSEEHARKLIEGIPARNAAGAAGGANSSALVLSRNRPAGAQPAGGKPQQRNEPQNMSLTRRPDSILAQPRPDWHPPWKLQRVISGHLGWVRALAIEPNNQWFASGAGDRTIKIWDMASGQLRLTLTGHISTVRGLAVSPRHPYMFSCGEDKMVKCWDLETNKVIRHYHGHLSGVYTLKLHPTLDVLVTGGRDGVARVWDMRTRSNVHVLSGHTGTVADLVCQEADPQVITGSLDSTVRMWDLAAGKTMGVLTHHKKGVRALTTHPTEFTFATGSTGSIKQWKCPEGAFMQNFEGHNAIINTLAVNDRNVFFSGGDNGSMSFWDWKSGYRFQALDTTAQPGSLDAESGIMSSIFDLSGSRLICGEADKTIKIWKEDPKATPESHPIDWKPTFAKRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M772</accession>
    <name>A0AAJ0M772_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-splicing factor SLU7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_76362</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the SLU7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727244.1">
        <property type="nucleotide sequence ID" value="XM_062871296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M772"/>
    <dbReference type="GeneID" id="87890125"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030628">
        <property type="term" value="F:pre-mRNA 3'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021715">
        <property type="entry name" value="Slu7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039974">
        <property type="entry name" value="Splicing_factor_SLU7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12942:SF2">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SLU7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12942">
        <property type="entry name" value="STEP II SPLICING FACTOR SLU7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11708">
        <property type="entry name" value="Slu7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="10">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="394"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3311464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="418" mass="46517" checksum="25A85C960D12E9D7" modified="2024-07-24" version="1">MAPPAPRRPERAPAASANTDSGSGAGAARKEDNIYIPSYISKQPFYVSGLDDHDDSLQHQRSRAAHEAENNFTIERGARQTGPARTKWVKGACENCGAMGHKKKDCLERPRKFGAKITGRDIQADRTVREVNLGFEAKRDVWAAFDPKQYDEVMENHSLIIESRNKKVKADDAFEEGFKYAEESELGKDKTVKQSMRIREDTAKYLLNLDADSAKYNPKKRALVDPGAIGDKSAQLFAEESFLRASGEAAEFEKAQRYAWEVQERTGDTSLHLQANPTAGALARKKENEEREAKRRKRAELLASQYGEQPTVPEALKAAITESEVFVEYDEAGLIKGAPRKAAKSKYPEDVFINNHTSVWGSWWSDFKWGYACCHSFVKNSYCTGETGKLASKERDLWDKSGGAQEGGTTEDGQDGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M796</accession>
    <name>A0AAJ0M796_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chaperonin 10-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_522181</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727438.1">
        <property type="nucleotide sequence ID" value="XM_062868607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M796"/>
    <dbReference type="GeneID" id="87887436"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="16"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3311658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="344" mass="36732" checksum="10BCC369BF5894AA" modified="2024-07-24" version="1">MPRMTSTQNTAAWLPGVGKELEVGPADTPVPDNNELLVEVKAVAVQPAEYKIQEGILPFPLKYPTIVDLSFSGVVVKVGSAVTRFNIGDRIVTNSAGTIRNDSRFGGYQRYALTTQELTADIGDVPFEQAASVSNLYGAASALFLHFGLEKSSHSPNKKAEKVHIWGASSSFGAYATQLAAEAGYTVVGVASAHNADLVHSFGSAHFVDRKSPTVSEDLIVLGPFKAVLAAADAAQDQMVLGSVLAAQGGGLFLSTMGLRPGVTLPEGVRGLFAQYVDDYLDLKNKEFTEWLWCDYLEQALQSGKLRVVPVRTLGGSSKVQEAWDLLHKGAVRGERLVIAPGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GKJ8</accession>
    <name>A0AAJ0GKJ8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit C</fullName>
            <shortName evidence="4">eIF3c</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 93 kDa subunit homolog</fullName>
            <shortName evidence="4">eIF3 p93</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Translation initiation factor eIF3, p93 subunit homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">NIP1</name>
        <name evidence="8" type="ORF">B0T15DRAFT_563036</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GKJ8"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000300">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03002">
        <property type="entry name" value="eIF3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027516">
        <property type="entry name" value="EIF3C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008905">
        <property type="entry name" value="EIF3C_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058999">
        <property type="entry name" value="EIF3CL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13937">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITATION FACTOR 3, SUBUNIT 8 EIF3S8 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13937:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05470">
        <property type="entry name" value="eIF-3c_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26569">
        <property type="entry name" value="EIF3CL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="7">
        <location>
            <begin position="603"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="806"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="821"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="839"/>
            <end position="849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3301643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="862" mass="97268" checksum="B3C339F589247CC3" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GKL0</accession>
    <name>A0AAJ0GKL0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Superoxide dismutase 1 copper chaperone</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Superoxide dismutase copper chaperone</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0T15DRAFT_404861</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CCS1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the C-terminal section; belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717439.1">
        <property type="nucleotide sequence ID" value="XM_062865270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GKL0"/>
    <dbReference type="GeneID" id="87884099"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006801">
        <property type="term" value="P:superoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000038">
        <property type="entry name" value="Superoxide dismutase 1 copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="SUPEROXIDE DISMUTASE CU-ZN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMA" evidence="11">
        <location>
            <begin position="6"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3301659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="261" mass="27912" checksum="3756166A8A890035" modified="2024-07-24" version="1">MAVMTPFQTLFAVPMTCDSCAKDITGALYKLPGINKVEANVKDQLVSIEGTAAPSAIVQAIQATGRDAILRGSGGSNSAAVSILETYHRRSDEEVTAAGSPGESWVNERLVRGLARMVQVSPTETLVDLTVRGVPPGTYRATIREYGNLKDGAVSAGPVWSAEAQDNRSSRGVLGTVEVGPNGYGNAFLNRPFQVWEVIGRALVVSRRDESDGEPLRNEEDTVVGVIARSAGVWDNDKTVCSCTGKTLWQERKDEVSKGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GL07</accession>
    <name>A0AAJ0GL07_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_563571</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717669.1">
        <property type="nucleotide sequence ID" value="XM_062870624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GL07"/>
    <dbReference type="GeneID" id="87889453"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3301889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="335" mass="37055" checksum="D858E518B8DEE33E" modified="2024-07-24" version="1">MSPKEEASFYLYSIGYSPALITLGTLVYRNYANPDHRCVSLSGIDENELVMQNLVSITEIDGCCWASAKSSTYGFGLRPLDLASVTSKYATSLQKMVVAEAGRRVTLNHPVRFFETKVLQHPDIRRELAIWLTAAKSSYLLRKATFQKPKVYCVTGLFELRGVRARVGSSSDINLDLGVSAEMVGAPTGIPIGLEIGPFSNNKYLMASVAMRKPAIWAARFHRLDVEYIRGDLEAELKPGLPTTIRLRPDVTDPGRGLMGDTGEEDEELYGEAQVLVGSNVQLTTGARMRMNDAVEEMSEDYCEEDEYSKAFAVAKHRIDEDAAASDEDDMNEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GLZ1</accession>
    <name>A0AAJ0GLZ1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_304553</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718191.1">
        <property type="nucleotide sequence ID" value="XM_062863849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GLZ1"/>
    <dbReference type="GeneID" id="87882678"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="233"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3302411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="486" mass="51962" checksum="01C8357E12E143CA" modified="2024-07-24" version="1">MAIPHTLPAALGAISFLPTTAILGIQIILARSPADRASTVRITAIVAATLEAMIFVIIPCLSLSHIAPWAPGSGLRGFRSLWFGAGLVLCTIASAMSVASLVCLSRVVNDPLSTILGWRVGNFLVGSSVVLGLAFATQAVFFASHVVVGRLHAAELHGSSRSDRGSKRLAPRIKTIPYHETAPISSKSRGNVSLDSQTPPGSIAGRSTTETMSSIRSSLSNVVRPITSRTRLLSASRQSLRRSASQDLPGLREVRTRSVSDGFDSWDTSSIAPENRQTVLESSSPPLGRSLETIPASPTVSRSSSPGTPLDLLEPPRTRRRSRSYSPVSTRTIEAQRAAFTQQPAHSEAHIHPLFRSDSPIPPPSATPGTVVVAAPDAGKVISDRQSIRSIQSMRRLRSESLPTVPSPLSRAASLDSFHRRAESNSPEIREEIREEDEAAVERKMTPPIPDWILAAGSRSTLTVYNGHRSQTPGEGGEKLDAAHQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GM49</accession>
    <name>A0AAJ0GM49_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YkoF-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_496689</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0045 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717995.1">
        <property type="nucleotide sequence ID" value="XM_062867197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GM49"/>
    <dbReference type="GeneID" id="87886026"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MTH1187/YkoF-like"/>
    </dbReference>
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        <property type="entry name" value="Thiamine_BP"/>
    </dbReference>
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        <property type="entry name" value="UPF0045_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00106">
        <property type="entry name" value="MTH1187 family thiamine-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33777">
        <property type="entry name" value="UPF0045 PROTEIN ECM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33777:SF1">
        <property type="entry name" value="UPF0045 PROTEIN ECM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01910">
        <property type="entry name" value="Thiamine_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89957">
        <property type="entry name" value="MTH1187/YkoF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiamine-binding protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3302215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="116" mass="12570" checksum="951D4A155502C897" modified="2024-07-24" version="1">MAPTDYSNVPTPFHCYVDFCLVPVGTGHASVAEEVAEVQKLLKASGLSYTMHSAGTTVEGNWDEVMKVIGQAHTVVHQKGAVRVQTSMRAGTRTDKAQTADQKVKRVEEILARDGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GMH5</accession>
    <name>A0AAJ0GMH5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nucleotide-sugar transporter-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_312155</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718447.1">
        <property type="nucleotide sequence ID" value="XM_062863941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GMH5"/>
    <dbReference type="GeneID" id="87882770"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10231">
        <property type="entry name" value="NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005799">
        <property type="entry name" value="UDP-gal_transpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="14"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="267"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="290"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3302667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="343" mass="37086" checksum="A55EACEDF81E6997" modified="2024-07-24" version="1">MHHSRNRPTGPQPLYLSSTAVLLVELIKLLASLVLAALDTCRSHPEASAYAAMRYLWSSIFGSDSWKLIVPAALYTLQNSLVYAAISNLDAVTFQVTYQLKILTTVLFSVLLLGRSISLRQWLSLVLLAFGVALVQVAGQLGADDWKARLTSLIRSGTVPTSNAFRGLMAVVAASLTSGLTCVYFEKLVKDSMTSVSLWTRNVQLSFFSLFPALFIGVIWQDGAAIAQDGFFVGYNPTVWTTIVLQALGGLIVAVCIAYADNVAKNFAASLSIVVSYAATTAISRKPVTLQATAGAAVVLLAMYLFNGRPAPRMVLLPVSQQRHESEKSRPLLCELTSIPPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GNB5</accession>
    <name>A0AAJ0GNB5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_419590</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3302895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718675.1">
        <property type="nucleotide sequence ID" value="XM_062865529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GNB5"/>
    <dbReference type="GeneID" id="87884358"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14019">
        <property type="entry name" value="STKc_Cdc7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF23">
        <property type="entry name" value="CDC7 KINASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="93"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="467"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3302895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="492" mass="56412" checksum="5769A9F2DA061E59" modified="2024-07-24" version="1">MAMVMGARRRRADSFQTESFRIHEDAPSTEDTEMNESALRDDDEVEQDGEPADDDGEESRSSGSSEEEFTDDSHIQQDMERLQNCFEGFRNKYRLIKRIGEGTFSTVYKAEDLLYDRYDNSWDLEKETEKWTPPPLKSFASESSTSLDYPSQSHRRRKPKYVAIKKIYVTSSPSRIFNELDLLHDLRGCDSVCPLITAFRWTDQVIAILPYFRHSDFRDYFRKMTVLDIAIYLRSLFTALASVHSHNIIHRDIKPTNFLYDPTSRRGVLVDFGLAEREGYDTKPCVCHEEPAARKRKLRPLITGPKGGMPREDTRPSRRANRAGTRGFRAPEVLFKCTEQTTKIDIWSAGVILLTILSRRFPFFNSADDVEAMIEIATIFGRDRMQMAAVLHGCMLETTIPTIPRSGFTFEGIIAWSTDRSGKGQKLPDDEKLAIEFLSRCMELDPSKRLSAEQALEHEFLRMGLDESVEGSSDPGYDDEDEINILKVEPEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GNC8</accession>
    <name>A0AAJ0GNC8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein S28e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_263730</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718891.1">
        <property type="nucleotide sequence ID" value="XM_062863376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GNC8"/>
    <dbReference type="GeneID" id="87882205"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04457">
        <property type="entry name" value="S1_S28E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000025">
        <property type="entry name" value="40S ribosomal protein S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000289">
        <property type="entry name" value="Ribosomal_eS28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028626">
        <property type="entry name" value="Ribosomal_eS28_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10769">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10769:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01200">
        <property type="entry name" value="Ribosomal_S28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00961">
        <property type="entry name" value="RIBOSOMAL_S28E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3303111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="68" mass="7694" checksum="63991815CC2F1FAD" modified="2024-07-24" version="1">MDSSKAPVKLVKVTRVLGRTGSRGGVTQVRVEFMDDTTRSIIRNVKGPVREDDILVLLESEREARRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GNU4</accession>
    <name>A0AAJ0GNU4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_513621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719223.1">
        <property type="nucleotide sequence ID" value="XM_062868055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GNU4"/>
    <dbReference type="GeneID" id="87886884"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3303443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="412" mass="46250" checksum="382795C86DE5EF73" modified="2024-07-24" version="1">MSSWPSGDWPSDSAEEGQQDRPTDPNSLGKLSPRGQIIGITPEQTERALKLLSVPFDSLPQVPPFAPFFGYTTQWHKVQVASSLAGFSAEMRRVLTTTEADALAYHRSRCCAISSWSPPLVLATTLYFTWRGRATLRFPFITPDPAKFNPNAFPTASRPFLTGPSAVRLWHGFRFGAYGIVCYFLVKGFVDSYAYTTYLMNVIADPRLKTIRDAAKTVRNQQSVPGTDAIQGAPGYERSTTIGSWSPQQQRQQQQQPAQQSAPQPQDAAQDDDTFLFDDASPVAPTQRQRPKQSSTSYNPSTGQGSAWDRVRSQAIAEQLNQRFEQAGEQTQQRMTDLEAALERFNNKQRRLGGRERTEQPTYGRSEQEKTEQYTYPTSEQEKAYAKEQAQKEFDAMLERERRGEGSSGGRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GPA8</accession>
    <name>A0AAJ0GPA8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycoside hydrolase family 31 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_281595</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719438.1">
        <property type="nucleotide sequence ID" value="XM_062863580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GPA8"/>
    <dbReference type="GeneID" id="87882409"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06591">
        <property type="entry name" value="GH31_xylosidase_XylS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051816">
        <property type="entry name" value="Glycosyl_Hydrolase_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43863">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G03140)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43863:SF2">
        <property type="entry name" value="MALTASE-GLUCOAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="4">
        <location>
            <begin position="24"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="3">
        <location>
            <begin position="231"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="5">
        <location>
            <begin position="576"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3303658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="667" mass="76553" checksum="B959EC43418F8CA8" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GPB7</accession>
    <name>A0AAJ0GPB7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Clr5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_540900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719432.1">
        <property type="nucleotide sequence ID" value="XM_062869817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GPB7"/>
    <dbReference type="GeneID" id="87888646"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025676">
        <property type="entry name" value="Clr5_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14420">
        <property type="entry name" value="Clr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clr5" evidence="2">
        <location>
            <begin position="89"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3303652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="645" mass="73794" checksum="BC83E710574105FA" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GPK5</accession>
    <name>A0AAJ0GPK5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_513912</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719557.1">
        <property type="nucleotide sequence ID" value="XM_062868079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GPK5"/>
    <dbReference type="GeneID" id="87886908"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF6">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="2">
        <location>
            <begin position="36"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3303777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="172" mass="18909" checksum="63DC4CE9C167FCE5" modified="2024-07-24" version="1">MFVCLGNRRDHTGIDIAALAGPGAGYFAYYDTEKPDTIIMAIDDLVEYVQSEEPFDGVLAFSHSRSRSGLGFSSVADRHSQKRQSKEEHLLRYCENALDCGRKPVITIPTVHLVGAQDKGLAECMKPVHLCCEDIGELFEHPGGHEIPISPVATEKMVATIQRGIKKALRAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GPP3</accession>
    <name>A0AAJ0GPP3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_561303</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719627.1">
        <property type="nucleotide sequence ID" value="XM_062870553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GPP3"/>
    <dbReference type="GeneID" id="87889382"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025444">
        <property type="entry name" value="Monooxy_af470"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13826">
        <property type="entry name" value="Monooxy_af470-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3303847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="378" mass="42264" checksum="89568ABFDDDE7156" modified="2024-07-24" version="1">MTRHLAVRHIRMVLHRSYNIYGDGLCQCRRHLRANTAWERLMTKVGEACKEVPYLATLVLSVKPDPRRSGREACWVAVRWSLRVLDCDTAAARVRLEIQAFIKDGFSLPTLLALGGVGQAIVSCILPARYALLPLAFLLLRAVVVTCLELASPPRYSSKLGVIRGRFSAQLPNASYDPSRGDDAKRPASPFGSTPAEQGIVMFHIGARINHPLGALAPAMKEFGDLTDAVTQELQARADEFGCLGMSAWRAADADSLNTSMAVIYFRDFEGLNRFAHDKVHRQVWDWYRNVFVKKHGYSHVGIFHEAFYAVPGAYETIYENMPPTLMSRAEASVRNEATGREEWVGTVVDASVKSSPAFRTQYSRLNRVVKRQMEASY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQ06</accession>
    <name>A0AAJ0GQ06_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_512223</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719799.1">
        <property type="nucleotide sequence ID" value="XM_062867962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQ06"/>
    <dbReference type="GeneID" id="87886791"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12283">
        <property type="entry name" value="RRM1_RBM39_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12284">
        <property type="entry name" value="RRM2_RBM23_RBM39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12285">
        <property type="entry name" value="RRM3_RBM39_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000291">
        <property type="entry name" value="CC1-like family splicing factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000172">
        <property type="entry name" value="RNA splicing factor Pad-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000354">
        <property type="entry name" value="RNA splicing factor Pad-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029123">
        <property type="entry name" value="RBM39_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006509">
        <property type="entry name" value="RBM39_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01622">
        <property type="entry name" value="SF-CC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48036">
        <property type="entry name" value="SPLICING FACTOR (PAD-1), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G15810)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15519">
        <property type="entry name" value="RBM39linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="184"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="282"/>
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        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
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            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="377"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="437"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
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            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="36"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3304019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="567" mass="63527" checksum="2051269293DDEE4C" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQ98</accession>
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            <fullName evidence="8">Tat pathway signal sequence domain protein</fullName>
        </recommendedName>
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        <name evidence="6" type="ORF">B0T15DRAFT_535651</name>
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    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719929.1">
        <property type="nucleotide sequence ID" value="XM_062869506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQ98"/>
    <dbReference type="GeneID" id="87888335"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045793">
        <property type="entry name" value="PcRGLX/YetA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048330">
        <property type="entry name" value="PcRGLX/YetA_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048331">
        <property type="entry name" value="PcRGLX/YetA_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048329">
        <property type="entry name" value="PcRGLX_1st"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40081">
        <property type="entry name" value="CONCANAVALIN A-LIKE LECTIN/GLUCANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40081:SF1">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19501">
        <property type="entry name" value="PcRGLX_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21345">
        <property type="entry name" value="PcRGLX_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21346">
        <property type="entry name" value="PcRGLX_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042470845" description="Tat pathway signal sequence domain protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="domain" description="PcRGLX/YetA-like N-terminal RIFT barrel" evidence="3">
        <location>
            <begin position="31"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="PcRGLX/YetA-like central beta-sandwich" evidence="4">
        <location>
            <begin position="131"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="PcRGLX/YetA-like C-terminal alpha/alpha toroid" evidence="5">
        <location>
            <begin position="506"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3304149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="950" mass="103714" checksum="72EC20B46633817F" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQI7</accession>
    <name>A0AAJ0GQI7_9PEZI</name>
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        <recommendedName>
            <fullName evidence="15">ATP-dependent RNA helicase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B0T15DRAFT_400245</name>
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        <name type="scientific">Chaetomium strumarium</name>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.</text>
    </comment>
    <comment type="function">
        <text evidence="15">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21 15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of pre-60S ribosomal complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="15"/>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719845.1">
        <property type="nucleotide sequence ID" value="XM_062865047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQI7"/>
    <dbReference type="GeneID" id="87883876"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17960">
        <property type="entry name" value="DEADc_DDX55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056330">
        <property type="entry name" value="CTT_SPB4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23681">
        <property type="entry name" value="CTT_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 14 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="46"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="284"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="542"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="566"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="582"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="592"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAK3304065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="652" mass="72514" checksum="172794220626F769" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQX4</accession>
    <name>A0AAJ0GQX4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">OPT oligopeptide transporter protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_418625</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720279.1">
        <property type="nucleotide sequence ID" value="XM_062865509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQX4"/>
    <dbReference type="GeneID" id="87884338"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045035">
        <property type="entry name" value="YSL-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER YGL114W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645:SF0">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER YGL114W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="148"/>
            <end position="167"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="205"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="292"/>
            <end position="312"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="369"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="481"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="525"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="618"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
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            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3304499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="754" mass="79789" checksum="685427E3BF43896E" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GRB8</accession>
    <name>A0AAJ0GRB8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphatidylinositol N-acetylglucosaminyltransferase GPI3 subunit</fullName>
            <ecNumber evidence="3">2.4.1.198</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GlcNAc-PI synthesis protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_537397</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalytic subunit in the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    <dbReference type="EMBL" id="JAUDZG010000005">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062869612.1"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017176">
        <property type="term" value="F:phosphatidylinositol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03796">
        <property type="entry name" value="GT4_PIG-A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphatidylinositol N-acetylglucosaminyltransferase GPI3 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000026">
        <property type="entry name" value="Phosphatidylinositol N-acetylglucosaminyltransferase subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039507">
        <property type="entry name" value="PIG-A/GPI3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013234">
        <property type="entry name" value="PIGA_GPI_anchor_biosynthesis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08288">
        <property type="entry name" value="PIGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIGA GPI anchor biosynthesis" evidence="10">
        <location>
            <begin position="44"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="9">
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            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF08288"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3304719.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GRH8</accession>
    <name>A0AAJ0GRH8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_558433</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720365.1">
        <property type="nucleotide sequence ID" value="XM_062870470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GRH8"/>
    <dbReference type="GeneID" id="87889299"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HSP70"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3304585.1"/>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAK3304976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062865035.1"/>
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    <dbReference type="GeneID" id="87883864"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
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    </dbReference>
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        <property type="entry name" value="UPF0173_UPF0282_UlaG_hydrolase"/>
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        <property type="entry name" value="L-ASCORBATE-6-PHOSPHATE LACTONASE ULAG-RELATED"/>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3304976.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GS24</accession>
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    <protein>
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        </recommendedName>
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        <name evidence="3" type="ORF">B0T15DRAFT_396946</name>
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    <organism evidence="3 4">
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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            <dbReference type="PubMed" id="37820761"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
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    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
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                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305076.1"/>
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    <feature type="non-terminal residue" evidence="3">
        <location>
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        <source>
            <dbReference type="Pfam" id="PF24883"/>
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        <source>
            <dbReference type="EMBL" id="KAK3305076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GS31</accession>
    <name>A0AAJ0GS31_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_369610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
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            <taxon>Chaetomium</taxon>
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    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720640.1">
        <property type="nucleotide sequence ID" value="XM_062864191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GS31"/>
    <dbReference type="GeneID" id="87883020"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3304860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="168" mass="19456" checksum="49D2330392822207" modified="2024-07-24" version="1" fragment="single">EGHIAYLTRWEELDQARRDEVRSCRIPRGAMGHPVIVLRRLSERPTHVLITCVSTHGAGPHDDFRAPWERPERMRALGAKVPEDFRAFHGSERPSQVSEYLHLEGYNAWPKSQTSWVNTQQVDLVPVAILGWFTKPRRPQPLRVTRASLEDLRDHMARANWGWGKPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GS41</accession>
    <name>A0AAJ0GS41_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HotDog domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_554944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720876.1">
        <property type="nucleotide sequence ID" value="XM_062870372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GS41"/>
    <dbReference type="GeneID" id="87889201"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052061">
        <property type="entry name" value="PTE-AB_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260:SF7">
        <property type="entry name" value="THIOESTERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G10800)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3305096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="222" mass="23979" checksum="A5EBEB8D7B9979B8" modified="2024-07-24" version="1">MAAARKYESATAILSTLSACNSLVPREDDSKAKEDYINSHPLTRSLRSDPNFTESRDHEKIPPAWRRQNLTGGPLMGPGRITIPPFSWTERGGKSYVQIAHIGTDLCGHLGIIHGALPFNVGMTAKLEINYMQPAVANQYLVLRATTVKVEGRKAWVEGHIETLPTGEGQQPTVLTTASALFISPKQASVQNGKGLPGITARKGGLSRGRAKVALLSGMQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GS46</accession>
    <name>A0AAJ0GS46_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_189101</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720917.1">
        <property type="nucleotide sequence ID" value="XM_062862422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GS46"/>
    <dbReference type="GeneID" id="87881251"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="118"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="30"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3305137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="227" mass="25084" checksum="807DE21FB17F81A7" modified="2024-07-24" version="1">MHWQIGNIEMTRRAGLVPFSLDISSNKLQDLEPISPNHGYAHSQSQGGSAARPLQPATNPHSAVNPAAYTDQAARETQVAPSTRLYLTNHPTTATNPTLAAPQPTPSPSAAVQAEKPHECSFCAHCFKNKREARRHRNSAHIQQHSWSCSVLTGYGQAFYDSTARPGTADVCGYCGKEFLRSVENQGVANASEQGWKERIGHPQELRKFGRCNLSKKFYRADSFRMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GSC9</accession>
    <name>A0AAJ0GSC9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_531800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721053.1">
        <property type="nucleotide sequence ID" value="XM_062869277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GSC9"/>
    <dbReference type="GeneID" id="87888106"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3305273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="27700" checksum="6683D7A4E26DC5D2" modified="2024-07-24" version="1">MQNQPPKYVSPPGTWRTKLALRAASVLFLIIIAGVGGSLAATPRVEMTAVMLLVLVPALLATFIWDAAEAICIWKREGNRGIHPGAVVAIDLFCWLGWAVVDLFLVASGVTSRPRYLIEDYSGYDDYRYTYDPSKVTPEDAQLEKDIMGKGEALVAFVSLTLIVHFVLFVIACYETNIRNRMPRTVYVMQPIYGPPSAVPGGYQPLGSFQGPPPPGPPLSPYQMYMQPPPSPLPTQPSPTHTPELKGGPDRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GSJ4</accession>
    <name>A0AAJ0GSJ4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase M20 dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_193298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721096.1">
        <property type="nucleotide sequence ID" value="XM_062862473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GSJ4"/>
    <dbReference type="GeneID" id="87881302"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052030">
        <property type="entry name" value="Peptidase_M20/M20A_hydrolases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575">
        <property type="entry name" value="PEPTIDASE M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575:SF0">
        <property type="entry name" value="XAA-ARG DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042538514" description="Peptidase M20 dimerisation domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3305316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="518" mass="55504" checksum="7E283C3E0AA9F34B" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GST8</accession>
    <name>A0AAJ0GST8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GPR1/FUN34/yaaH family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_532274</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721224.1">
        <property type="nucleotide sequence ID" value="XM_062869304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GST8"/>
    <dbReference type="GeneID" id="87888133"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015123">
        <property type="term" value="F:acetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051633">
        <property type="entry name" value="AceTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047622">
        <property type="entry name" value="GPR1_FUN34_YAAH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038013">
        <property type="entry name" value="AceTr_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123:SF1">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01114">
        <property type="entry name" value="GPR1_FUN34_YAAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3305444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="291" mass="31028" checksum="A791746F6A899666" modified="2024-07-24" version="1">MADTTNPGEKDTAHTTSAAPANGANTAHHRGPWNPMANIHADDQPRLPAFGGEFQPGLWRSMEHRKFANPAPLGLSAFALTTFVLSAVNLNARGVNVPNIAVPLALGYGGLVQLLAGMWEMAVGNTFGATALSSYGGFWIAYGILLTPNWNILGAGGPYMSEAAKAVDPKMGNSAVGFFLTGWFIFTTILLLCTLRSTVMFFLLFFTLDLAFLMLACGEYATDNNNPTAALKLTQAGGGFGMIAAFLAWYNAFAGIADSSNSFFLIPVFHFPWSEKGREARLAKTASRTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GSU6</accession>
    <name>A0AAJ0GSU6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_198811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721261.1">
        <property type="nucleotide sequence ID" value="XM_062862548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GSU6"/>
    <dbReference type="GeneID" id="87881377"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35006:SF3">
        <property type="entry name" value="GLYOXALASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G06020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35006">
        <property type="entry name" value="GLYOXALASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14830)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="545"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="366"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3305481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="572" mass="62640" checksum="057018D1FB2EC992" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GSX1</accession>
    <name>A0AAJ0GSX1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Aconitate hydratase, mitochondrial</fullName>
            <shortName evidence="13">Aconitase</shortName>
            <ecNumber evidence="13">4.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0T15DRAFT_532662</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>citrate = D-threo-isocitrate</text>
            <dbReference type="Rhea" id="RHEA:10336"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="EC" id="4.2.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="13">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.-" evidence="13"/>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721322.1">
        <property type="nucleotide sequence ID" value="XM_062869322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GSX1"/>
    <dbReference type="GeneID" id="87888151"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01578">
        <property type="entry name" value="AcnA_Mitochon_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01584">
        <property type="entry name" value="AcnA_Mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000002">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000003">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000004">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1060.10:FF:000001">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1060.10">
        <property type="entry name" value="Aconitase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050926">
        <property type="entry name" value="Aconitase/IPM_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015932">
        <property type="entry name" value="Aconitase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006248">
        <property type="entry name" value="Aconitase_mito-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01340">
        <property type="entry name" value="aconitase_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005558">
        <property type="entry name" value="PRK07229.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160">
        <property type="entry name" value="ACONITATE HYDRATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160:SF3">
        <property type="entry name" value="ACONITATE HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0408">Iron</keyword>
    <keyword evidence="9 13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="14">
        <location>
            <begin position="73"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="15">
        <location>
            <begin position="590"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3305542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="787" mass="84916" checksum="FEAFDA1B35F0A287" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GT68</accession>
    <name>A0AAJ0GT68_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_206220</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721472.1">
        <property type="nucleotide sequence ID" value="XM_062862625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GT68"/>
    <dbReference type="GeneID" id="87881454"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF177">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER MCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="321"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="411"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="446"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="481"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="110"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3305692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="512" mass="54692" checksum="E46C87B9101910D2" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GTT6</accession>
    <name>A0AAJ0GTT6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ClpP/crotonase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_216914</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3306043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721823.1">
        <property type="nucleotide sequence ID" value="XM_062862748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GTT6"/>
    <dbReference type="GeneID" id="87881577"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000058">
        <property type="entry name" value="Enoyl-CoA hydratase/isomerase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF171">
        <property type="entry name" value="SD19268P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3306043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="344" mass="37423" checksum="58F6D307AEA8D6BD" modified="2024-07-24" version="1">MHPRFSITLNASTALRVGQQALRRARYSTEANAGPLIRVTDLPAPNSGHIRILELNRPAARNAISRALLSSLRDEIDAVHTQYDAATGDEIPAPSWSKRFGGIAGDDQKGPTRALILASAVDTSFCAGADLKERKSFTQEETAAFLLNLRTTLTSLSALPIPTISAISSLALGGGLELALATHFRVLSSNAVVGLPETRLGIIPGAGGTYRLPALIGIPRARDLILTGRRVSAPEAYFLGLADRLVEVLPESEEQAKEWQALEDKEREERILHMARRLALSEAVRLASEICEGGPVAIRAAIRAVEEPREVVENNMYERVVRTEDRDEALKAFAEKRKPVFKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GUI2</accession>
    <name>A0AAJ0GUI2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_430860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722094.1">
        <property type="nucleotide sequence ID" value="XM_062865724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GUI2"/>
    <dbReference type="GeneID" id="87884553"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3306314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="315" mass="35424" checksum="B50D93CB50A98B38" modified="2024-07-24" version="1">MNTATGPLLPSSSEACDPPEYSNATTTTTTANEPPADQPPTYREESGPDPDEILPPATFALHGRFIYLATDSSSTTTTTTATTTTTSSDPLYQLSRVIHVTSRATESIDFQRLDYRVRTTTGNTGAQDSFSPKVSRRPHDVYQLKYTPGLAYTGLQPQFRLLPQSRKTVGEVSIERGSLPLFRSGWRALRVLGEGERKRLEREGKKVSKKGEYHFVIKEKGQGQEDGWEWVDPAGKVVASQQVLGSEGGEAAAAEVEYRLKVLVPLPRRVLDGLVAMWCLWLWRIHLDKTTERKTWEDRKRILHQRRQYVSKMGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GUL5</accession>
    <name>A0AAJ0GUL5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_393788</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722243.1">
        <property type="nucleotide sequence ID" value="XM_062864705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GUL5"/>
    <dbReference type="GeneID" id="87883534"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000573">
        <property type="entry name" value="RHO family GTPase Rho2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3306463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="201" mass="22182" checksum="D0C0C922C9AB45AE" modified="2024-07-24" version="1">MANDRNAQNVIRRKLVIIGDGACGKTSLLSVFTLGFFPTHYIPTVFENYVTDCRVDGKSVQLALWDTAGQEDYERLRPLAYAKAHVILIGFSIDTPDSLDNVKHKWVLEANERCPGVPIILVGLKKDLRDDPVAQEEMRKRSQRFVSPGDGEHAAKEIGARKYLECSSLSGEGVDDVFEAATRASLLMLEKVEGAGCCVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GV06</accession>
    <name>A0AAJ0GV06_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP phosphoribosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_491912</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722140.1">
        <property type="nucleotide sequence ID" value="XM_062866816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GV06"/>
    <dbReference type="GeneID" id="87885645"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41774">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41774:SF1">
        <property type="entry name" value="NGG1P INTERACTING FACTOR NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3306360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="113" mass="12202" checksum="64B90B9ACEC1E51C" modified="2024-07-24" version="1">MASALARYKLVFHVPPAALEACKAAIFAAGAGRYPGPGNYTECCYTTMGTGQFRPGDAANPHIGKVGELEHVEEARVETLCVGEDVARRAVAALKKAHPYEEPAYEVYKLEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GVI0</accession>
    <name>A0AAJ0GVI0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_528550</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722686.1">
        <property type="nucleotide sequence ID" value="XM_062869046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GVI0"/>
    <dbReference type="GeneID" id="87887875"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576:SF158">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 12-LIKE CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576">
        <property type="entry name" value="UNCHARACTERIZED NODULIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="444"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="479"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="525"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="201"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="205"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="246"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3306906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="562" mass="60283" checksum="8643D2A66ACBB955" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GVP2</accession>
    <name>A0AAJ0GVP2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Replication protein A C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_484236</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722776.1">
        <property type="nucleotide sequence ID" value="XM_062866218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GVP2"/>
    <dbReference type="GeneID" id="87885047"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04478">
        <property type="entry name" value="RPA2_DBD_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040260">
        <property type="entry name" value="RFA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014646">
        <property type="entry name" value="Rfa2/RPA32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014892">
        <property type="entry name" value="RPA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989">
        <property type="entry name" value="REPLICATION PROTEIN A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989:SF16">
        <property type="entry name" value="REPLICATION PROTEIN A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08784">
        <property type="entry name" value="RPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036949">
        <property type="entry name" value="RPA32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OB" evidence="5">
        <location>
            <begin position="54"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Replication protein A C-terminal" evidence="6">
        <location>
            <begin position="144"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3306996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="261" mass="28049" checksum="E993F9F43387F0C0" modified="2024-07-24" version="1">MVASQQGSQSQGQGGEKKWANESLRPITIKQLIDCKEAYPKAELAVDGLPTTQVTLVGQIRSINQQTVNVTYRIDDGTGIINVKKWIDADKADSAPSFALDTYVRVYGRLTTWDGRKHVGAHYIRAIEDFNEVNYHLLEATYVHLALTRVAEGGEHQQQGQMGAADGGDGMFVDDGYGGGGGGGGGADSHTIRLRLGPCSRNANAIYRYLANSAGDAQHLNQVAAGTGISVRDILAAADELVNQGLIYTTENDETWAILDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GVT6</accession>
    <name>A0AAJ0GVT6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Synaptobrevin homolog YKT6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0T15DRAFT_529153</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptobrevin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722867.1">
        <property type="nucleotide sequence ID" value="XM_062869088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GVT6"/>
    <dbReference type="GeneID" id="87887917"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.50:FF:000017">
        <property type="entry name" value="Synaptobrevin-like protein Sybl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000004">
        <property type="entry name" value="Vesicle-associated membrane protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051097">
        <property type="entry name" value="Synaptobrevin-like_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136">
        <property type="entry name" value="SNARE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136:SF168">
        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Longin" evidence="11">
        <location>
            <begin position="11"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="152"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3307087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="238" mass="26310" checksum="4C7FD1BF093B5961" modified="2024-07-24" version="1">MASSSTPATPLLYACIAHNTTILAECTTSASSQTSSLASLILPKIDHSAPQKLTYTHGNHHIHYIASSPSEYPPAQPTAGGLTYLVISDASAINRRLAFGFLTELRKRFLEQYPAETTDFSDLPNYGAAGFNGEMRGLMVEYGRVNEQGDDAITNVRREIDDVRGIMTRNIEGLLERGERIDLLVDKTDRLGGNAREFRVRSRGLKRRMWWKNVKLMGLLGFVVVLIIVTIVVSVKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GW89</accession>
    <name>A0AAJ0GW89_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hamartin protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_484253</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722800.1">
        <property type="nucleotide sequence ID" value="XM_062866221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GW89"/>
    <dbReference type="GeneID" id="87885050"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033596">
        <property type="term" value="C:TSC1-TSC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032007">
        <property type="term" value="P:negative regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007483">
        <property type="entry name" value="Hamartin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15154">
        <property type="entry name" value="HAMARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15154:SF2">
        <property type="entry name" value="HAMARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04388">
        <property type="entry name" value="Hamartin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="417"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="796"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="600"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="487"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="852"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="876"/>
            <end position="888"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3307020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="888" mass="99043" checksum="36F10251687F6315" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GWI9</accession>
    <name>A0AAJ0GWI9_9PEZI</name>
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        <recommendedName>
            <fullName evidence="3">Sister chromatid cohesion protein DCC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_173000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723080.1">
        <property type="nucleotide sequence ID" value="XM_062862215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GWI9"/>
    <dbReference type="GeneID" id="87881044"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019128">
        <property type="entry name" value="Dcc1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09724">
        <property type="entry name" value="Dcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3307300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="151" mass="15750" checksum="E838FFC5B5A9207F" modified="2024-07-24" version="1">MSSQSNTGIPLSHALHGAAYKLLELPPELLELLESGDPPILTLHPSETAALLKTPSKTYSLRQKNTSNALILLSPQGGGGGCPRENDANPSDHHCDGGNGARVVPHTGLTAIATVHETIELVPEADVAAVTGTTAAPKARGKWHEKFGKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GWN4</accession>
    <name>A0AAJ0GWN4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_382826</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723010.1">
        <property type="nucleotide sequence ID" value="XM_062864257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GWN4"/>
    <dbReference type="GeneID" id="87883086"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="48"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="304"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="328"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3307230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="362" mass="39591" checksum="ECF852F501D9FD68" modified="2024-07-24" version="1" fragment="single">MSSPTPDGTGGSGVIGPPTPDQDHGDQGPNMIAAAFTAWTISLVFVLLRFWTRARIVHSLGPTDWFIALALIASGGMCVSAVEQCKHGMGKHMYDIDMHVDYAPMMEAWWFTLLCYILALALTKVSVCLLYLTIFTFEWARRACYAILVIVVTANIWATATTFTYCIPLEAAWNPNVVASFCQPQAAWWVNTGLTLATDIIIVILPIPIVLPLKLPRRQKLIVVGIFAVGFLVCLVSLIRLAILLQFKSDESSSAPDAFDFTYHSAKLFYCTTLEVNTAIVVACAMTLKPLLARFLPRLLHHHHQSAKPGEEDPSAVSSGGPPLTIGSRPSRQKQQAQSQGYHRPQAVVVVVEEELVGEGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GX70</accession>
    <name>A0AAJ0GX70_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Siderophore iron transporter mirB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_565239</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3307754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723534.1">
        <property type="nucleotide sequence ID" value="XM_062870665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GX70"/>
    <dbReference type="GeneID" id="87889494"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000284">
        <property type="entry name" value="Siderophore iron transporter mirB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF107">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G04730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="396"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="421"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="459"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="536"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="53"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3307754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="570" mass="61597" checksum="2F3BACCC0884DA59" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GXC4</accession>
    <name>A0AAJ0GXC4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_522848</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3307869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723649.1">
        <property type="nucleotide sequence ID" value="XM_062868653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GXC4"/>
    <dbReference type="GeneID" id="87887482"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF30">
        <property type="entry name" value="MID2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="193"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="290"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="211"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="303"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3307869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="353" mass="35567" checksum="2799F25816552379" modified="2024-07-24" version="1">MATVYPPETNDGVVTSWVPLTTTFTPSIGCETKFRLNGPSLVAYDPGYGLDIDPRVKCAPPAVTTWWEQGRLGGGDDPGHTAASLGPMTCPNAWTTVVTSVRDASSTLAMCCPPDYYLANGISGSVAGDCRSDVPSGAVLTFASTPLGESDAWSIATTTLARRSVVGAIAVVGWSIAVQTAATSLSSSLTTTTTSSTLSATTTTTPPPTSAPSTSILPTEPTIGAPGAASISISSSSSSPSGESGSSGLPTGAAIGIGVGIGLGVVGIAALLATMYLLRSRKAKAAAAAEAEAAMSGTQPPAEGGPPPPPPPPPKSAEAYGPHELWPEAVRSELPGSHQQQQQQYGVRPYELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GXD8</accession>
    <name>A0AAJ0GXD8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_523070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3307933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723713.1">
        <property type="nucleotide sequence ID" value="XM_062868664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GXD8"/>
    <dbReference type="GeneID" id="87887493"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3307933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="263" mass="29418" checksum="B6A685FFEB660CE9" modified="2024-07-24" version="1">MLCLPGSTSSSSSPHDIFISTFTTQWHHIFETQIRRDFRRLSSSHRSEVIATKEDFLYRDASGQRSGHTWIRTVSLYTPSQLLEALSPLAETLESVHLQFIDLGQLSISPQEADRLSTNALNALITSITPFRALKGSRHRVPSLAFLESSARPGQGLSTAPRPPCPFKAPNPKGDVIRFEDAVSKRHIPNALREVRLYGGLSGLHASGWVPTDWSIPQDSIRNRPPYPKRTYRKGSIQVISLNSTYKIKERAFEELEAEVLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GXE2</accession>
    <name>A0AAJ0GXE2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ubiquitin-related domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_522939</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3307899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723679.1">
        <property type="nucleotide sequence ID" value="XM_062868657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GXE2"/>
    <dbReference type="GeneID" id="87887486"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036435">
        <property type="term" value="F:K48-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032435">
        <property type="term" value="P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903094">
        <property type="term" value="P:negative regulation of protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031397">
        <property type="term" value="P:negative regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46340">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46340:SF1">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22562">
        <property type="entry name" value="UBA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBA" evidence="6">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="79"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="36"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="140"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="199"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="199"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="224"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3307899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="313" mass="34409" checksum="2E91019E5419A01F" modified="2024-07-24" version="1" fragment="single">MTQSDLDLLLEMGFERARAELAVKKTGGLQQALTWLEENQDKPLEELQASQASAATAGEGEGDEEGAPSIPSGVTAQSLVCNECGKKFRNHDQASFHASKTDHTDFSESTDEIAPLTEEEKKAKLEELRRKLQEKRANQAILDKEESKRNEQIRLKATKESQDIKEQLQRKEQMKEAAKKRQEKLEDLEAKKRIKARIEADRAERKRREEEAKAMRGGKPLPNPTTTPAAPSAAAGSSAAVARLRLQTAKGNLVKSFPSETTLFEVAQQIEAEVGAPIQSFSLTFPRKTFEAGVDFGQTLAEAGLAPSAVLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GXN2</accession>
    <name>A0AAJ0GXN2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tetratricopeptide SHNi-TPR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_93701</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723789.1">
        <property type="nucleotide sequence ID" value="XM_062871469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GXN2"/>
    <dbReference type="GeneID" id="87890298"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051730">
        <property type="entry name" value="NASP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019544">
        <property type="entry name" value="Tetratricopeptide_SHNi-TPR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15081:SF1">
        <property type="entry name" value="NUCLEAR AUTOANTIGENIC SPERM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15081">
        <property type="entry name" value="NUCLEAR AUTOANTIGENIC SPERM PROTEIN NASP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10516">
        <property type="entry name" value="SHNi-TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Tetratricopeptide SHNi-TPR" evidence="5">
        <location>
            <begin position="255"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="89"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="314"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="435"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="341"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="143"/>
            <end position="168"/>
        </location>
    </feature>
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        <location>
            <begin position="174"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="440"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10516"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3308009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="465" mass="50402" checksum="6B8C0829038D25DB" modified="2024-07-24" version="1">MATPTPATGASTPQVELDPEETAKSLKVSLADRAAKAAALYAHKQYEEAAEVYAQAAEMQAEMNGEMDPENAEILFLYGRALFKVGQSKSDVLGGKAPESKKPAKMKPPKAAKSANGSSPATAEKKNDTTEVAGSSAAAIAEAESKLDEVVAEAASKEEEAPKPEQKKPLFQFEGDDNFVDSEQEDGAEEGEGDEEEEEEDDLAVAFEVLDLARVLFNKRLEATQAEDEAQQGKGKEAAEDGDSAVAKHIKERLADTHDLLAEISLENERYHNAITDSRASLKYKEQLYPFESEVIAEAHFKLSLALEFASVTKSSEDDDKEAGGGSGDDKIDQALRDEAAAELEAAINSTKQKLQNKEVELATLHDPEDNEASRRQIADVKEVLADMEQRLVDLRKPPVDINAALGIPASAQQQIPKVLPDEVKNNATDLTGLVRKKRKAEEKPAEEQEIEAKKAREDGDAKMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GXT2</accession>
    <name>A0AAJ0GXT2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_86264</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3307830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062871399.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87890228"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="WD40"/>
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    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NACHT" evidence="5">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="727"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="949"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1033"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1088"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1130"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1172"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1237"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1290"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="94"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="354"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="871"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1206"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1368"/>
            <end position="1389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="368"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="880"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1376"/>
            <end position="1387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3307830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1474" mass="164402" checksum="49EE646CF3299A0B" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GYJ5</accession>
    <name>A0AAJ0GYJ5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">H/ACA ribonucleoprotein complex subunit NOP10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Nucleolar protein 10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Nucleolar protein family A member 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">snoRNP protein NOP10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_109754</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NOP10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724311.1">
        <property type="nucleotide sequence ID" value="XM_062861486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GYJ5"/>
    <dbReference type="GeneID" id="87880315"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904874">
        <property type="term" value="P:positive regulation of telomerase RNA localization to Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031118">
        <property type="term" value="P:rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.40">
        <property type="entry name" value="H/ACA ribonucleoprotein complex, subunit Nop10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007264">
        <property type="entry name" value="H/ACA_rnp_Nop10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036756">
        <property type="entry name" value="H/ACA_rnp_Nop10_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13305:SF0">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13305">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NOP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04135">
        <property type="entry name" value="Nop10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144210">
        <property type="entry name" value="Nop10-like SnoRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3308531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="62" mass="7197" checksum="FCF60D168FB3C27A" modified="2024-07-24" version="1">MHLMYLPTADGSGRRYTLKKVMDGQVTKSAHPARFSPDDKWSRHRLAIRKRFAVLLEQAKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GYR8</accession>
    <name>A0AAJ0GYR8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_491206</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724418.1">
        <property type="nucleotide sequence ID" value="XM_062866756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GYR8"/>
    <dbReference type="GeneID" id="87885585"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03749">
        <property type="entry name" value="proteasome_alpha_type_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000016">
        <property type="entry name" value="Proteasome subunit alpha type-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035144">
        <property type="entry name" value="Proteasome_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3308638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="269" mass="29404" checksum="A7ABE2887929FCE5" modified="2024-07-24" version="1">MFRNNYDNDSVTFSPQGRIFQVEYAAEAVKQGSVVVGIASKTHAVLVAIKRNAEELSSYQKKLFPIDEHVGIAIAGLTSDARVLSNFMKQQCLGHRLTYGRNMPVRTLVDMIGSKAQVNTQHYGKRPYGVGLLVAGVDEQGPHLFEFQPSGMTEEMVAFAIGARSQMARTYLEKNIDKFADCDREELIRHGLRALKESLVQDRELTVDNTSVGVSGIVKADDGSIKIEPFRVYDGQEVVAWIESVADDKEGGAEGGAAAAEGESMEVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GYU0</accession>
    <name>A0AAJ0GYU0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">nitrilase</fullName>
            <ecNumber evidence="4">3.5.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_524294</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a nitrile + 2 H2O = a carboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:21724"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18379"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="EC" id="3.5.5.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.5.1" evidence="4"/>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724165.1">
        <property type="nucleotide sequence ID" value="XM_062868754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GYU0"/>
    <dbReference type="GeneID" id="87887583"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000257">
        <property type="term" value="F:nitrilase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07564">
        <property type="entry name" value="nitrilases_CHs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.110.10:FF:000011">
        <property type="entry name" value="Cyanide hydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000132">
        <property type="entry name" value="Nitrilase/CN_hydratase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044149">
        <property type="entry name" value="Nitrilases_CHs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044:SF14">
        <property type="entry name" value="ARYLACETONITRILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044">
        <property type="entry name" value="NITRILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00920">
        <property type="entry name" value="NITRIL_CHT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="6">
        <location>
            <begin position="5"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00036406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3308385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="342" mass="36771" checksum="455DF815BFBB1C75" modified="2024-07-24" version="1">MTTPIRVAAVQAEPVYLDLAASVNKACGLIGEAAKGGAKLVAFSECWVPGYPAWIWARPVDVAMQTQYINNSLSIHSPEMDQIKAAARDHSVAVALGFSERTPSGSIYISQAIISRRGEVLMHRRKLKPTHMERTVFGDGSGRDLANVVEVDFGTHGTVNVGCLACWEHTQPLLKYHTISQGETIHVAMWPPIAPSAGIEDPGLWSMSAEGCLNLSQTYAIESAAYVVHTTAVCNQECIAAMRTQDGIVCRQPGGGHSCVIGPDGRRLTAPLGDGTGVDEGIVYADLDVARTTATKGFLDIVGHYSRPDLLWLGVDRRQKEVVVAVGSSRGVDHETNKRDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GYY7</accession>
    <name>A0AAJ0GYY7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Origin recognition complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_117238</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the origin recognition complex (ORC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ORC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724517.1">
        <property type="nucleotide sequence ID" value="XM_062861576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GYY7"/>
    <dbReference type="GeneID" id="87880405"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007220">
        <property type="entry name" value="ORC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056772">
        <property type="entry name" value="RecA-like_ORC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056773">
        <property type="entry name" value="WHD_ORC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04084">
        <property type="entry name" value="RecA-like_ORC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24882">
        <property type="entry name" value="WHD_ORC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Origin recognition complex subunit 2 RecA-like" evidence="7">
        <location>
            <begin position="252"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 2 winged-helix" evidence="8">
        <location>
            <begin position="495"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="185"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3308737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="528" mass="57862" checksum="895B42C8D092635E" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GZZ8</accession>
    <name>A0AAJ0GZZ8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_515156</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725076.1">
        <property type="nucleotide sequence ID" value="XM_062868165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GZZ8"/>
    <dbReference type="GeneID" id="87886994"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3309296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="56" mass="6694" checksum="85A8746233B627F3" modified="2024-07-24" version="1">MVTSDPFPSFKASTDQQWSQMRRFRLLELHSLRPDGRWYFVGRGGEDPHDSEQRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H0G0</accession>
    <name>A0AAJ0H0G0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">R3H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0T15DRAFT_5444</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NFX1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725314.1">
        <property type="nucleotide sequence ID" value="XM_062870066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H0G0"/>
    <dbReference type="GeneID" id="87888895"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06008">
        <property type="entry name" value="NF-X1-zinc-finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="CDD" id="cd06006">
        <property type="entry name" value="R3H_unknown_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.50:FF:000006">
        <property type="entry name" value="NF-X1 finger transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034078">
        <property type="entry name" value="NFX1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034077">
        <property type="entry name" value="R3H_FAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000967">
        <property type="entry name" value="Znf_NFX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12360">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR, X-BOX BINDING 1 NFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12360:SF12">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR NF-X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01422">
        <property type="entry name" value="zf-NF-X1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00438">
        <property type="entry name" value="ZnF_NFX"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="R3H" evidence="11">
        <location>
            <begin position="860"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="146"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1135"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="146"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1138"/>
            <end position="1174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3309534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1234" mass="134276" checksum="39623C7FB15450AD" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H0H1</accession>
    <name>A0AAJ0H0H1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_526747</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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</entry>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
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                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
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                <person name="Natvig D.O."/>
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                <person name="Ament-Velasquez S.L."/>
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                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
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                <person name="Hiltunen Thoren M."/>
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            <strain evidence="2">CBS 333.67</strain>
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                <person name="Kuo A."/>
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                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
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                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
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                <person name="Martin F."/>
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                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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                <person name="Calhoun S."/>
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                <person name="Kuo A."/>
                <person name="Mondo S."/>
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                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
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                <person name="Barry K."/>
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                <person name="Grigoriev I.V."/>
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                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
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                <person name="Kuo A."/>
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                <person name="Andreopoulos B."/>
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                <person name="Chen C."/>
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                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
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                <person name="Martin F."/>
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                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
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                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
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    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </location>
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        <location>
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            <end position="272"/>
        </location>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3309863.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="294" mass="33218" checksum="3115A42FC425D0C0" modified="2024-07-24" version="1">MPKNRPTEVAYNAVRDDMQTYLDNAEPEQISLPQWGVTTWQNAHGERRASSRHTFHIGFRYMRDTGDYWTCILVDTRTEGSLPVAGTFINWGTNPPTPREVLLLYQNARFPLSRDFKPSRSGSGGGQGGAGGAGGSSSGGASGWKKEIHEDGYGGYFYYDADWEYHQCDRNGNDTYTTQAGGYRTSNPHSFKAVFGPPPNTYYYHRGRRMPCKLNTDKRNQTWFEDAQKRTWNAKYYASEPRHSQSSSSASHRSATTASQSQGGHKTSTQRKYFTDEESGKRYYVDSAGKTRWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H1C0</accession>
    <name>A0AAJ0H1C0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B0T15DRAFT_481509</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the U5 snRNP complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. DDX23/PRP28 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725792.1">
        <property type="nucleotide sequence ID" value="XM_062866028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H1C0"/>
    <dbReference type="GeneID" id="87884857"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17945">
        <property type="entry name" value="DEADc_DDX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000322">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057479">
        <property type="entry name" value="PRP28/DDX23-like_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25430">
        <property type="entry name" value="DDX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 14 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="18">
        <location>
            <begin position="271"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="302"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="516"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="31"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="82"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="673"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="13">
        <location>
            <begin position="271"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAK3310012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="706" mass="80002" checksum="6DC4F5E882AB158F" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H1N2</accession>
    <name>A0AAJ0H1N2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">STI1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_516778</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">Part of a larger complex that includes HSP70, HSP90, and immunophilins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725664.1">
        <property type="nucleotide sequence ID" value="XM_062868275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H1N2"/>
    <dbReference type="GeneID" id="87887104"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042030">
        <property type="term" value="F:ATPase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.100:FF:000004">
        <property type="entry name" value="Putative stress-induced-phosphoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000010">
        <property type="entry name" value="Stress-induced phosphoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000020">
        <property type="entry name" value="Stress-induced phosphoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.100:FF:000002">
        <property type="entry name" value="Stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000027">
        <property type="entry name" value="stress-induced-phosphoprotein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041243">
        <property type="entry name" value="STI1/HOP_DP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006636">
        <property type="entry name" value="STI1_HS-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904:SF523">
        <property type="entry name" value="STRESS-INDUCED-PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904">
        <property type="entry name" value="TPR REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17830">
        <property type="entry name" value="STI1-HOP_DP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00727">
        <property type="entry name" value="STI1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="4"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="72"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="STI1" evidence="8">
        <location>
            <begin position="140"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="334"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="STI1" evidence="8">
        <location>
            <begin position="534"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="199"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="239"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="251"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00064323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3309884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="586" mass="65131" checksum="D735F6D880CD0474" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H1N6</accession>
    <name>A0AAJ0H1N6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine-threonine protein kinase 19-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_488879</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STK19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725972.1">
        <property type="nucleotide sequence ID" value="XM_062866552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H1N6"/>
    <dbReference type="GeneID" id="87885381"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046579">
        <property type="term" value="P:positive regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018865">
        <property type="entry name" value="STK19-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15243">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15243:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10494">
        <property type="entry name" value="Stk19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="76"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00093458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3310192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="450" mass="46124" checksum="552D0133E054EBF4" modified="2024-07-24" version="1">MTQSPSLRSILGGSRVKKRTSSANKRSSSSWTSTLAQTKPGAAPSKLLVPPQSPIDPGHGRSSEENPGPSPPPALLPSAATNSNPTSSSSSSSTPLPSSRNPTLQIHQHILDSMFDPFPPNLAGLGSARIAAAARFRAAFPPLVSVAHLQAQLLLLLPLATTTTPGAPPSPSPSPAAAERAMAALVRAGLARKIVIPTLRRVGGRAGELFISSEALGRMVEGAAGLGAEVKEIFGRWLRDHPAAVRISRGELGGVVGLGAGEVDALVRAGFLTAGHEQGSGGGGKGLYARPEERYAMISLEAVARAAAGSVAAVGGERVLHAAGGTGARSMGGSGAVAGEFSVAVPGSGVFLKLASAAVEHLAELLHKTQHREMSESDLREKWDGGVVGSSDATLAKKARGEFAGVMPGRTKKWKQFHGLAFGWVLQEAVGAGLVEVFDTRSVGRGVRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H266</accession>
    <name>A0AAJ0H266_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nab2-like CCCH zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_387023</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZC3H14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725930.1">
        <property type="nucleotide sequence ID" value="XM_062864360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H266"/>
    <dbReference type="GeneID" id="87883189"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043488">
        <property type="term" value="P:regulation of mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.30:FF:000002">
        <property type="entry name" value="Nuclear polyadenylated RNA-binding protein Nab2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.40:FF:000002">
        <property type="entry name" value="Nuclear polyadenylated RNA-binding protein Nab2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055046">
        <property type="entry name" value="Nab2-like_Znf-CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040366">
        <property type="entry name" value="Nab2/ZC3H14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14738">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14738:SF29">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22683">
        <property type="entry name" value="Nab2-like_zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nab2-like CCCH zinc finger" evidence="9">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="261"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="495"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="298"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3310150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="514" mass="55397" checksum="84C4E5F5E2849414" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H278</accession>
    <name>A0AAJ0H278_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_564470</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726272.1">
        <property type="nucleotide sequence ID" value="XM_062870642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H278"/>
    <dbReference type="GeneID" id="87889471"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF232">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3310492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="498" mass="57238" checksum="04F93E82A4314435" modified="2024-07-24" version="1">MPLLAWPAIVVQLLLAAIGLFVWRRYLSPLADIPGPFVASFSRWWHIRHILIGDQNRQLVQLHEKHDTVSVHFCLGHFVRIAHNEVSVSHPDGVKQLLLHPLWKAKWYEISQLPDYRYKSAMSALDPRKKAERSRNLAPGYRLSNVIKSEDAISRTIEMLLDWMDAYAEKHEPMQLDRFFTYTAFDVVGEVLFSKKFGFLQQGADIRNAISNSLALNAFATVLGFFQPWNRIIANPFVTWLQITPMGHLFDIAMTALNEREKNQDARFDVVAHWFRMLAQHPERMQLRDIHVQTINSVSAGADTVSCGLQSFIYHMLRHPTAWHRVRAEIDAACRERGLCADRVVAFDHAQQLPYLQACIKEALRVFGPVPMGLPRVAPKGGLTIGDRTFPAGTILSINPWVIHYSKEIWGLDAHEFNPDRWLSDSAAALEKFWIPFGVGYASCPGQNIAKIELSKILATIVRDYDIRQVYKDQEWKYKAYFTAVPHSWPCYIEKRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H2X4</accession>
    <name>A0AAJ0H2X4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_426510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726621.1">
        <property type="nucleotide sequence ID" value="XM_062865650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H2X4"/>
    <dbReference type="GeneID" id="87884479"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000021">
        <property type="entry name" value="GTPase activating protein (Gyp2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000015">
        <property type="entry name" value="GTPase activating protein (Gyp2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="278"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="778"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="850"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1040"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="779"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="868"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="903"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1040"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1067"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1087"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1104"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1126"/>
            <end position="1141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3310841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1154" mass="126666" checksum="CAFDD17B30305B64" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H3T9</accession>
    <name>A0AAJ0H3T9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nucleoporin Nup120/160-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_386291</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727081.1">
        <property type="nucleotide sequence ID" value="XM_062864316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H3T9"/>
    <dbReference type="GeneID" id="87883145"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059141">
        <property type="entry name" value="Beta-prop_Nup120_160"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056548">
        <property type="entry name" value="HEAT_Nup120"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021717">
        <property type="entry name" value="Nucleoporin_Nup160"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048884">
        <property type="entry name" value="Nup120_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21286">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21286:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11715">
        <property type="entry name" value="Beta-prop_Nup120_160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23300">
        <property type="entry name" value="HEAT_Nup120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21486">
        <property type="entry name" value="NUP120_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup120/160 beta-propeller" evidence="5">
        <location>
            <begin position="75"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup120 helical" evidence="6">
        <location>
            <begin position="613"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin nup120-like HEAT repeat" evidence="7">
        <location>
            <begin position="841"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="19"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="768"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF21486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3311301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1226" mass="137156" checksum="FA4A1D9A7A517CCA" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H3U0</accession>
    <name>A0AAJ0H3U0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SPT2 chromatin protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_66570</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SPT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726997.1">
        <property type="nucleotide sequence ID" value="XM_062871176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H3U0"/>
    <dbReference type="GeneID" id="87890005"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="PROTEIN SPT2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22691">
        <property type="entry name" value="YEAST SPT2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SPT2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SPT2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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            <begin position="1"/>
            <end position="382"/>
        </location>
    </feature>
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            <begin position="16"/>
            <end position="26"/>
        </location>
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        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
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        <location>
            <begin position="341"/>
            <end position="368"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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        </source>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3311217.1"/>
        </source>
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        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="382" mass="41544" checksum="4A1523EEC508BC32" modified="2024-07-24" version="1">MPILDLLASITGEKPTPSPNPVPQPGIIPRKRKAEDELRPAAARAAKAESMPEKPSRPDHSSPRPSPRPADRPTISSGKPTSKAPHGSDKPVSTARPGLAGSNGSKTGKASLNNSKSLPSRLVPSRPTVPDSAPPKKRSYAEIMARAKANSEMRESLGKIHHKTVERSTMTKERKETKTDGLKKPRMATGKVMSGRAGSTSMPLRDVGRASSARQNVPSDSKSAQKTAPMEEKKVKKAALATTGYTGTARPRPGTSSTGKSGAAGRPGSAARSRDRPRFGGPVSSSRKKYDEDDDLDDFIEYDDEEEEAGYGIGNQYRYDSYEEESDMEAGLSDIEDEEQRAERQARREDMEQEALEMRLKREKEERKRRLLTAAKANAGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H3W5</accession>
    <name>A0AAJ0H3W5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Nitrogen permease regulator 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4 5">Required for meiotic nuclear division protein 11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_499310</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
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        <text evidence="3 5">Mediates inactivation of the TORC1 complex in response to amino acid starvation. Required for meiotic nuclear division.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Vacuole membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the NPR3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062867336.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056603">
        <property type="entry name" value="HTH_NPRL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005365">
        <property type="entry name" value="Npr3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13153">
        <property type="entry name" value="CGTHBA PROTEIN -14 GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13153:SF5">
        <property type="entry name" value="GATOR COMPLEX PROTEIN NPRL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24064">
        <property type="entry name" value="HTH_NPRL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03666">
        <property type="entry name" value="NPR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0469">Meiosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="GATOR1 complex protein NPRL3 C-terminal HTH" evidence="7">
        <location>
            <begin position="844"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="40"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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        </location>
    </feature>
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        </location>
    </feature>
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    </feature>
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        </location>
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    </feature>
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        </location>
    </feature>
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        </location>
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        <location>
            <begin position="795"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
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            <end position="836"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00010546"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00017880"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00030028"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU368069"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3311321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="895" mass="98852" checksum="CE86428ED9B17ACC" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H4B0</accession>
    <name>A0AAJ0H4B0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_387671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727353.1">
        <property type="nucleotide sequence ID" value="XM_062864399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H4B0"/>
    <dbReference type="GeneID" id="87883228"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3311573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="188" mass="20654" checksum="A2FA4BF253219034" modified="2024-07-24" version="1" fragment="single">QARREAQKAAKQDNELKKQIQNLLKKGETAQAAQKARMLLAKQAIAAQMDQAADMAELSLAQIQANNAMNRMTAMMAQSSKTMQRAQRSANPERTLLTLEQFRSQNEEYAMSNGIYQDAMTQSTSVVAQVSDDAVHELLGKLADDAGLELGQELSQATTSKVDPVKEPAEPTPEVEDALQQRLRALRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H508</accession>
    <name>A0AAJ0H508_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_508205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727445.1">
        <property type="nucleotide sequence ID" value="XM_062867701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H508"/>
    <dbReference type="GeneID" id="87886530"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043:SF8">
        <property type="entry name" value="DUF4220 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="470"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3311665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="519" mass="58622" checksum="BE59CCC8F07911DB" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LXM4</accession>
    <name>A0AAJ0LXM4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Coronin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0T15DRAFT_316948</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Binds to F-actin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the WD repeat coronin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717372.1">
        <property type="nucleotide sequence ID" value="XM_062864005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LXM4"/>
    <dbReference type="GeneID" id="87882834"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000197">
        <property type="entry name" value="Coronin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015505">
        <property type="entry name" value="Coronin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015048">
        <property type="entry name" value="DUF1899"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856:SF0">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08953">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16300">
        <property type="entry name" value="WD40_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM01166">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01167">
        <property type="entry name" value="DUF1900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="DUF1899" evidence="11">
        <location>
            <begin position="4"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="77"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="133"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="175"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="413"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="460"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="461"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="472"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="489"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="508"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00062568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU280818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3301592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="612" mass="66815" checksum="9B3817B5F4F2C5C6" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LXW3</accession>
    <name>A0AAJ0LXW3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_544268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717433.1">
        <property type="nucleotide sequence ID" value="XM_062870055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LXW3"/>
    <dbReference type="GeneID" id="87888884"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042519660" evidence="1">
        <location>
            <begin position="27"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3301653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="88" mass="9758" checksum="6AEF3BF088CEC3E7" modified="2024-07-24" version="1">MTGVILSWPALALALLLLFMVKKSPSGGKRKAGVSGEGWRRQQTASDLRFRKYAIQYRDRVYTNNGRMLAFCGVLDGGQLRKAPQQGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LY96</accession>
    <name>A0AAJ0LY96_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histidine phosphatase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_291909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717884.1">
        <property type="nucleotide sequence ID" value="XM_062863724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LY96"/>
    <dbReference type="GeneID" id="87882553"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07040">
        <property type="entry name" value="HP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051710">
        <property type="entry name" value="Phosphatase_SH3-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469:SF51">
        <property type="entry name" value="TRANSCRIPTION FACTOR TAU 55 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3302104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="328" mass="35522" checksum="227A0C9612E60FC5" modified="2024-07-24" version="1">MLEVIYVTRHGFRSNWLVDPSSGSYTTFIKSPTGGAADPALTAHGVDQANELAVRLLDADPPIARVYSSLYYRCLQTVEPFVRRAQEAAASAGERRLRIRGETGLGEWYGSASFEHPVPASVGTLEQLFPGMLDPDYGPAVTPNRTGESVDELHDRVAATLEALIAECDRDGVRAILLCSHAAVIIAMGRVLTGHMPENVEVEDFKCFTCGLSMYRRQPPNNRLISAESRASRDGIMRQATDACGVDHHAKAGSALGTSWRAGKGISGGWNCELNSDCTHLSLGAERGWRFSGDESFTDMATGQSILDARPDRGKNSAHREEGSRGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LYC7</accession>
    <name>A0AAJ0LYC7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_295529</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717960.1">
        <property type="nucleotide sequence ID" value="XM_062863758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LYC7"/>
    <dbReference type="GeneID" id="87882587"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051711">
        <property type="entry name" value="Stress_Response_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540:SF1">
        <property type="entry name" value="ACTIVATOR OF STRESS GENES 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="110"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="746"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="901"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="982"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1001"/>
            <end position="1011"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3302180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1045" mass="116514" checksum="DDDC661B7BDE0A17" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LYU7</accession>
    <name>A0AAJ0LYU7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_543679</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718485.1">
        <property type="nucleotide sequence ID" value="XM_062870013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LYU7"/>
    <dbReference type="GeneID" id="87888842"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3302705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="121" mass="13597" checksum="26F97023BDCE39C8" modified="2024-07-24" version="1">MRKERLDSCLTQSLFLVRFRGVPGHPSLTLTSHLPHSLPFHKSPTLRKLHSQVGFDSFQLKSNTPKMRATAFLVSFLVALATAAPEMTMEKRTERIVCDCDEDMCRGPPCCDNGTCWQSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZG5</accession>
    <name>A0AAJ0LZG5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_560442</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719202.1">
        <property type="nucleotide sequence ID" value="XM_062870530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZG5"/>
    <dbReference type="GeneID" id="87889359"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF98">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="51"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
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            <begin position="402"/>
            <end position="501"/>
        </location>
    </feature>
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            <begin position="407"/>
            <end position="445"/>
        </location>
    </feature>
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        <location>
            <begin position="475"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3303422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="501" mass="55016" checksum="DA33D804F435F387" modified="2024-07-24" version="1">MSFASSSNPSSVSSSPLSLNPVRKADLVLAKHKVFRGGSETDHRIPPFPFVGRGASLGRSGTTTVYRVAPPDGYDYRRPLALKVISCQGEKQLLGSDSEARSRALKEVKTMSRLRHPHIVAYVASFESFCFNTRLIRYCLQKRTGIGAPSEQRVKDHVLAIAMYPPAGGNLNTFMSDVFLDPSRAKWIIPRLHSFFGCLTQAVTHLHKQGVQIWHKDIKPENIVVDDFGQPMLTDSGLSKHFETGDYSEGPTPKTLKYADPESLAEQRRDERSDIFSLGCVYLEIVTVLLGQPAKNTSNRRSEDRPFKYADALPNLPTYLATLTSLGHELAASDPSRERSVHALLPVLPRIQEMMSATQHLRPEAHQLYPWFYHLYSVYDQIVGGGVCANCEAERRTGNVIIIPGPSSSQSSSSSQNRNQSGMLSRTSTVGSGVGGAPSSSSSQGHGHRRRRTPSHNLRLRLGPLQDEDDEGGNPASSQWIPPSSQWIPTSSPVDVGECSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ0M0G5_9PEZI</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">B0T15DRAFT_512501</name>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720118.1">
        <property type="nucleotide sequence ID" value="XM_062867986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M0G5"/>
    <dbReference type="GeneID" id="87886815"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3304338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="401" mass="44968" checksum="E9ACE2A25A4FEB13" modified="2024-07-24" version="1">MQYRTNYGKEQRPAGPWPGGRPYKGPARLPEGHFDPDELTRRLYVVLAEQRLQAERKQRARGERSDRRDGTRHQEKQQKPAEPAADLITKLRRTESAENKPTHTALAAPPPDVATNQASQYHHVPSQAASQFVRTTTVDNIRNNDLVHKLSKRALKFHLDGPRTVRPAAVPEEGGGHGGETAIAPAKLSRTLQQTQTQRDKVLDRNQFQRTRILEEAAQLDHHEQQPPRKHTLEDEFLRLLRPASRHDKRRNSTGNAADMHSANDNRNHHVRRSLIAMEPLLDVLAEEKYNLSTTNSTTAPLPAEEPPLCRFPPADRTRVDWTQSDEPRAHNGRPKLLLSLPLLRKADSLWTLRGIGRRGSKDSSVQSPTGGSAAGVPEGKGDELSPTKAGKTGFFAKFKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <protein>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720359.1">
        <property type="nucleotide sequence ID" value="XM_062863131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M0L5"/>
    <dbReference type="GeneID" id="87881960"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3304579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="297" mass="33744" checksum="E3394DC759749764" modified="2024-07-24" version="1">MGSYINPDEIQHFLSRYRRSAVDDDQEPYFGYANQPRGYQPAAAGNGVLEDTSSSEFDDWRSEVTMTSTVKSPAYTVSTGRSAARSSVFSQDDSRSLVGPSSAPSSAPSVGVPQMTWMQQFGNPVAPPPVAHQILWCEFSGLMGCQATFGLDEENRWIEHHAAHLNGLFPQRLICWFCDDFKFVAENPTDGHANFVQRMQHVRDHIWEDHRLTSGNNRPDFDMVQHLYACGLLSEERYDWAMSFDESPYPLPGSHSHPSLAQGPKKTIIIEREKGRAHDLAKEKRELRRKKERKVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M0Q3</accession>
    <name>A0AAJ0M0Q3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_537374</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720491.1">
        <property type="nucleotide sequence ID" value="XM_062869608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M0Q3"/>
    <dbReference type="GeneID" id="87888437"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3304711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="85" mass="9652" checksum="33125F4E13944BC3" modified="2024-07-24" version="1">MSWIRVLLVTYSFPTPKILCHGPPLSFSSGLHMEYMDDRKVEFETADTLYGLTPSARNHIIRSQPILLRYRTSGIGVKTVDILTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M0X2</accession>
    <name>A0AAJ0M0X2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="16">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">B0T15DRAFT_504063</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="16">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Associates in the nucleolus with the 60S and pre-60S ribosomal subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="16">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="16"/>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720674.1">
        <property type="nucleotide sequence ID" value="XM_062867484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M0X2"/>
    <dbReference type="GeneID" id="87886313"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17942">
        <property type="entry name" value="DEADc_DDX18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000379">
        <property type="entry name" value="RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000460">
        <property type="entry name" value="RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044773">
        <property type="entry name" value="DDX18/Has1_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 15 21" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 16" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="20">
        <location>
            <begin position="111"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="142"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="331"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="559"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="14">
        <location>
            <begin position="111"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAK3304894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="585" mass="65027" checksum="313475D46C969C45" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M0Z4</accession>
    <name>A0AAJ0M0Z4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_433510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3304985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720765.1">
        <property type="nucleotide sequence ID" value="XM_062865777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M0Z4"/>
    <dbReference type="GeneID" id="87884606"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10527">
        <property type="entry name" value="SET_LSMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF76">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3304985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="476" mass="53646" checksum="4D0A94CCF8516932" modified="2024-07-24" version="1">MSEAKVTQFPLDDLPAWCARHGVKLHPLIKAVNVDGHGNGWIALESNGPFSSQDEVLLLSIPREVIFSTAYVKEYANANESFRQLFEALPEFSPRLLIILFMLVQLALLQSSSQPDRDVVEPWREYTLLQSADVLVSTMWSPAELSPLKDTSLESTVAAKLALLQREFSLITLRTRSLRFWHETLFHNNGEPVSLQHWIWLDALFRSRSFDLPRSGESMVPCLDLANHSNENTAYFRQETQTESVTLMIRREIISALCPGDEITISYGRDKPAAEMLFNYGFIPQDPNGSTTSVEQSESLMISLDDTPSWTHWARDDPFLAAKLELFNDAPMLRLSVDREGVASWSCSFVYILCVGEEDGFEFKKAQGEDGRSGWTLLWHGKEISRMAGMLGLWLNAQGELSGVVQGRLVSVLSGVVADQLKKMRPLEVDAGVVKDGNHGIRPSVLRSVIQLRKVETRILERCLQALEEERNRLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M1C8</accession>
    <name>A0AAJ0M1C8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GTPase activating protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_511308</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721166.1">
        <property type="nucleotide sequence ID" value="XM_062867904.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87886733"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05137">
        <property type="entry name" value="RasGAP_CLA2_BUD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF60">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN RASKOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="531"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="4">
        <location>
            <begin position="738"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="114"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="174"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1136"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1249"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="209"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1150"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1252"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1263"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1276"/>
            <end position="1289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3305386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1304" mass="143897" checksum="658D65BA05214D56" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M1K7</accession>
    <name>A0AAJ0M1K7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_203618</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721406.1">
        <property type="nucleotide sequence ID" value="XM_062862604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M1K7"/>
    <dbReference type="GeneID" id="87881433"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045048">
        <property type="entry name" value="FBXO31/39"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10706">
        <property type="entry name" value="F-BOX FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10706:SF130">
        <property type="entry name" value="F-BOX ONLY PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12014">
        <property type="entry name" value="Cyclin_D1_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="4">
        <location>
            <begin position="14"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="181"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3305626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="496" mass="55774" checksum="C374E3A397C4EA81" modified="2024-07-24" version="1">MGKHRHYSSAPGSKSSLLGLPSELLSTILAYLSPTDLANVSETCRAMYGHATADHLWQALVQANVPGQRVISSYPCLSFRELFKKHYPRWFVPKYKIWFSDTGLSGRVIVTRYDQLRGCIEGYQLVANQIDDSDPQIWEGDGESTISDFHPEVKLHLDHPILRLAVDEATDEAEADHIAVRISRPDGREESASSLQASSSTSKDEERPEGNRFQAEIPMRLAGDDHIRSSFIHARACHPSEPGATQLWPPTTVPASRRVASVSVEFVETPDSLGPVHVAASRGAVFDQAFRIHKWIEMRIFGFNPRADPGIGPRLIRIGQEVSTYATLDPKLYTPTPDRPYRGIWVGQYGSHGCEILWINQPDQPDDAFNADGIPRLEHESDEGYERRKHDATIHRGRLEAVKLTGDANVPRGEYSFICDDLGDGGFVRVSDQRPFEGVRVVKSRGHVADHGFVDDFYIFGHLMLISPDRLAHHWIDLKHISYYQRIDIDQFLATH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M1Q1</accession>
    <name>A0AAJ0M1Q1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RPAP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_208957</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RPAP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721541.1">
        <property type="nucleotide sequence ID" value="XM_062862646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M1Q1"/>
    <dbReference type="GeneID" id="87881475"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039913">
        <property type="entry name" value="RPAP1/Rba50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013929">
        <property type="entry name" value="RPAP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013930">
        <property type="entry name" value="RPAP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21483">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21483:SF18">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08620">
        <property type="entry name" value="RPAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08621">
        <property type="entry name" value="RPAP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RPAP1 N-terminal" evidence="4">
        <location>
            <begin position="132"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="RPAP1 C-terminal" evidence="3">
        <location>
            <begin position="356"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="86"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="175"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="186"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="276"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3305761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="496" mass="54530" checksum="BC9BC7616358C252" modified="2024-07-24" version="1">MLAPPKLVRWPDCLQGQRHLRNSSTSWLALFYCNHYHIPGVCKMEVTLHVNDIQEKYDVKPPSSIISPPSGPDFPVQKTRLSAFKRRLQGKPAGTSSVRTTSSTSSTVSDPKSSSRNGAPSRRDTGMDERRGIDEETDAVLSSMSPEQITEAQKELYNGLDPKFLRMLLKRANLDEPTDPSPFRTASSEASPSADSPPTSKSRHITVEDEPEEPPEVAPGPVPEPDEGKPSGKPKKSVTFHFDEDAPPPIEAIDLFPVTEAPKAVSKANASKLKAGNNNAPQDVTNNTHFPRPPRVPDLDPSDPDFLETMHKKFFPNLPADPSKLAWMAPIPTPGSTADQESPYYPGQDSLPVSALRFDFRGALLPPRVSRAIPVTKGLHHHGEAPEAAGYTIPELAKLARSAMPAQRCLAYQTLGRMLYRLGRGEWGPGAGGRNGEEDDLAFSLWRCFQEGRVLESLEAEASLPEGKGHLSSKAYATEALWLFEKGGWRERWRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M1S4</accession>
    <name>A0AAJ0M1S4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Superkiller protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_396091</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721557.1">
        <property type="nucleotide sequence ID" value="XM_062864812.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87883641"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055087">
        <property type="term" value="C:Ski complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039226">
        <property type="entry name" value="Ski3/TTC37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040962">
        <property type="entry name" value="TPR_22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15704">
        <property type="entry name" value="SUPERKILLER 3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15704:SF7">
        <property type="entry name" value="SUPERKILLER COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18833">
        <property type="entry name" value="TPR_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13176">
        <property type="entry name" value="TPR_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="458"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="655"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="987"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="320"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="336"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3305777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1425" mass="157825" checksum="4377BA895655B0E9" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M1X3</accession>
    <name>A0AAJ0M1X3_9PEZI</name>
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        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_494004</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721648.1">
        <property type="nucleotide sequence ID" value="XM_062866986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M1X3"/>
    <dbReference type="GeneID" id="87885815"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
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    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3305868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="226" mass="25476" checksum="C3DFCE80A093A209" modified="2024-07-24" version="1">MTGHAPTSEQDPRQSTVGSYAQYIEALLSGSSLEGTDWYKDCEELKNFLTSYFNDKAHQDPGVKQALESMVSRYGQYTRVLEIAEARLRDQIDMISSGKSNEMAERSIQESKRAILLTVLAFIFLPVSLASSIYGMNVQQINASGLDIRAFVITAIVLLLVTVLLWAGASAVVAYRNHRIEKWQSRKRDDPYSAERSRRDNILLIGSRKDDPRISRKVVEKLTSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M287</accession>
    <name>A0AAJ0M287_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_137774</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722112.1">
        <property type="nucleotide sequence ID" value="XM_062861842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M287"/>
    <dbReference type="GeneID" id="87880671"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3306332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="244" mass="27498" checksum="BEB5560CA3CE3C6A" modified="2024-07-24" version="1">MLPARRAALAILRRTQVAFRQLIAHLQKVTPRGQKPILATPPQTDLYRCAMYLHQKLSEAGVPYYFCGGFACINVGMTARSTADIDIAVPNGAHGYGTLLNILSRPPFIQDKTGTLPRDSYYFFVESSGNFVEVDGVIAGFMQFPTLEQAKVIQAGKTMKLNFLEPTGLLKLKFDAWSKKSRREGPKRNGDITDITSLRDLLISNRARMDLVELKGEFAKGLREWVREFGDLKQWQKLDPKYRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M2C2</accession>
    <name>A0AAJ0M2C2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pantoate--beta-alanine ligase</fullName>
            <ecNumber evidence="3">6.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Pantoate-activating enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Pantothenate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0T15DRAFT_492014</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(R)-pantoate + beta-alanine + ATP = (R)-pantothenate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pantothenate synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.1" evidence="3"/>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722250.1">
        <property type="nucleotide sequence ID" value="XM_062866828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M2C2"/>
    <dbReference type="GeneID" id="87885657"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004592">
        <property type="term" value="F:pantoate-beta-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00560">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1300.10:FF:000002">
        <property type="entry name" value="Pantoate--beta-alanine ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1300.10">
        <property type="entry name" value="Pantoate-beta-alanine ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00158">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003721">
        <property type="entry name" value="Pantoate_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042176">
        <property type="entry name" value="Pantoate_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00018">
        <property type="entry name" value="panC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21299">
        <property type="entry name" value="CYTIDYLATE KINASE/PANTOATE-BETA-ALANINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21299:SF1">
        <property type="entry name" value="PANTOATE--BETA-ALANINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02569">
        <property type="entry name" value="Pantoate_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3306470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="344" mass="37299" checksum="F4DF0EFCF84C7C42" modified="2024-07-24" version="1">MASHCSSRPGPSSPGGGLEKLPSSSIRVLRSVESLRRWRRPHLLDRRSVALVPTMGALHEGHLSLIRAAARENHHVVVSIYVNPAQFGVREDLSSYPVTWDADAAALVKLDRELADDGQNLGRISAVFAPTTAEMYPGGFPGQEVLEGRSRPTFFRGVATVCMKLFNIVQPERVYFGQKDVQQTVVIKRLVRDFMLPIEVVVGPTARAEDGLALSSRNVYLGGRRRGVATVLYRALQAAEEAYKSGARDRGAVLGAAEKLLGEALSEQTALAPERRVRFEVDYVSLADPDTMEELPVVDPAKGGILSGAVKMLPVEVPRDGEDLGHSGGPAVRLIDNIILQPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M2S1</accession>
    <name>A0AAJ0M2S1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Matrin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0T15DRAFT_154351</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3A2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722593.1">
        <property type="nucleotide sequence ID" value="XM_062862032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M2S1"/>
    <dbReference type="GeneID" id="87880861"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2690:FF:000002">
        <property type="entry name" value="Splicing factor 3a subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052092">
        <property type="entry name" value="SF3A2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031781">
        <property type="entry name" value="SF3A2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205:SF0">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16835">
        <property type="entry name" value="SF3A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01050">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="11">
        <location>
            <begin position="54"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="70"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3306813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="247" mass="27955" checksum="93F40EAD771C9E6E" modified="2024-07-24" version="1">MDYQNRAGSKFGGGGVASHSATNADRRERLRKLALEQIDLDKDPYIFRNHLGSFECRLCLTVHQNDGSYLSHTQGKKHQTNLARRAAREQKEGKGEVDPHTGLPVGVVGAGFAALGLGTGGPRKNVVKIGRPGYKITKVRDPITRQQGLLFQLQYPDIGTGVTPKWQVMSAFSQRVEEPDRNFQYLLVAAEPYETCGFKIPARELDKREDRQFEFWDPDAKEYWIQIMFMTEREERFNAAPGLTGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M2Y3</accession>
    <name>A0AAJ0M2Y3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_528286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722579.1">
        <property type="nucleotide sequence ID" value="XM_062869030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M2Y3"/>
    <dbReference type="GeneID" id="87887859"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3306799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="168" mass="17760" checksum="58360E3D8E4DEBB5" modified="2024-07-24" version="1">MATHGSSARPAAPAAQTVVAPPTAAEKDRDREARRQAHWERWAADADKERSYAVVFDKQAGTSAAATDAVHRMLGRPPKLSPVKRLPDLTDTATDLGQVQISMVSAEIFVALREQFHCTRISVMLPGNHKRTAFIPGAAKDGAGASRNVAAAAPAAAGAKQQGKNSQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M338</accession>
    <name>A0AAJ0M338_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_166516</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722953.1">
        <property type="nucleotide sequence ID" value="XM_062862169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M338"/>
    <dbReference type="GeneID" id="87880998"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004493">
        <property type="term" value="F:methylmalonyl-CoA epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046491">
        <property type="term" value="P:L-methylmalonyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.180.10:FF:000034">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.180.10:FF:000039">
        <property type="entry name" value="Trihydroxytoluene oxygenase (AFU_orthologue AFUA_8G02470)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051785">
        <property type="entry name" value="MMCE/EMCE_epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43048">
        <property type="entry name" value="METHYLMALONYL-COA EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43048:SF3">
        <property type="entry name" value="METHYLMALONYL-COA EPIMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="171"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3307173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="346" mass="39665" checksum="738B0A8FAC83481C" modified="2024-07-24" version="1">MASGLPSNPIKKIQLVRIAHVWYKHEDIEKAKKFALDFGFVDTAQVGKTTFYRGYGTEPFVLALEAADKNEFGGAAFVVESEEDLVHASKVLPKECRATEVHEMKDVPGGGKRVTFYDPVDGFPFHLVYGQTPVALEDPGFPMLKFNYPCEKNRGPNEFQRFKKRPAPVHKLGHFGMCVTNFAKCYEFYSSYFNFHPSELVHNDQGVDNTVFFRLNRGDELVDHHCFFFFEGPKMHVHHSSFETHDFDAQVLGHDWLRHQGYTNCWGVGRHVMGSQIFDYWFDPSGFIMEHYVDGDLLDMREPTHRTKAAPDNLHVWGKLLSRQCQPDRIVLIDSIGPEVPATFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M381</accession>
    <name>A0AAJ0M381_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CCT-beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_432960</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723206.1">
        <property type="nucleotide sequence ID" value="XM_062865760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M381"/>
    <dbReference type="GeneID" id="87884589"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03336">
        <property type="entry name" value="TCP1_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000002">
        <property type="entry name" value="T-complex protein 1 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012716">
        <property type="entry name" value="Chap_CCT_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02341">
        <property type="entry name" value="chap_CCT_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3307426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="530" mass="56931" checksum="DA7E3146C5641A41" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M393</accession>
    <name>A0AAJ0M393_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mannan endo-1,4-beta-mannosidase A</fullName>
            <ecNumber evidence="4">3.2.1.78</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Endo-beta-1,4-mannanase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0T15DRAFT_174253</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random hydrolysis of (1-&gt;4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans.</text>
            <dbReference type="EC" id="3.2.1.78"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.78" evidence="4"/>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723118.1">
        <property type="nucleotide sequence ID" value="XM_062862230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M393"/>
    <dbReference type="GeneID" id="87881059"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016985">
        <property type="term" value="F:mannan endo-1,4-beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046355">
        <property type="term" value="P:mannan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000076">
        <property type="entry name" value="Mannan endo-1,4-beta-mannosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045053">
        <property type="entry name" value="MAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451:SF39">
        <property type="entry name" value="MANNAN ENDO-1,4-BETA-MANNOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 11 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042581345" description="Mannan endo-1,4-beta-mannosidase A" evidence="12">
        <location>
            <begin position="19"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="13">
        <location>
            <begin position="60"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00077212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3307338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="369" mass="40176" checksum="F36EE9DD7F599358" modified="2024-07-24" version="1">MMKAVFTIGLGLLSAAQALPSARAPGSATVNGTRFSIDGKTGYFAGTNSYWIGFLANNRDVDTVMSHISSSGLKILRVWGFNDVNARPGSGMVWYQLLSSSGSQINTGADGLQRLDYVVQSAEKRGVKLIINFVNNWDDYGGMNAYVKAFGGTKEGWYTNAKAQDQYKKYIRAVVSRYANSPAVFAWELANEPRCKGCSTDVVYKWATDVSAYIRSLDPSHMITLGDEGFGLPGDTTYPYGYSEGVDFVKNLGIKNLDFGTFHMYPDSWGVPYSFGDGWIKNHAAACKAAGKPCVLEEYGAYARCDIQKPWQQSSLSLATQGMAADMFWQWGDQLSTGQTHNDGNTVYYGSALATCLVTDHVTAINAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M3Y3</accession>
    <name>A0AAJ0M3Y3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_490715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723897.1">
        <property type="nucleotide sequence ID" value="XM_062866704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M3Y3"/>
    <dbReference type="GeneID" id="87885533"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14686">
        <property type="entry name" value="bZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052635">
        <property type="entry name" value="Sec_Metab_Biosynth_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39607:SF2">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39607">
        <property type="entry name" value="XANTHOCILLIN BIOSYNTHESIS CLUSTER TRANSCRIPTION FACTOR XANC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="116"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3308117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="276" mass="29794" checksum="D9F83EA7FE71D543" modified="2024-07-24" version="1">MFPYQLPEDQDYIEVQHPEEQLDQDNAGQGRTEPSTPRQSKRSPSASTRSAKSGSKGKGSKTTTVGSGSDTEKESAKMASSRSSKHSSSSRKDKSSSSSKVKKTDNWAEVTEPDERRRIQNRIAQRKFREKAREQKDRAQREAQNQQLAGSAYHIPDPDDFSLADDSGDLSGLPWGGISMRHVVSRGHASASAGQHTHSHHSGTNVSTPGPAVGPVDQALYNLNPYGGYPAQDSSMSGGGGGAGDVYYDSPYAGGYYDFDPSGAGDGHHHHHLHQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M402</accession>
    <name>A0AAJ0M402_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Acyl-CoA dehydrogenase/oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_482824</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3307924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723704.1">
        <property type="nucleotide sequence ID" value="XM_062866127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M402"/>
    <dbReference type="GeneID" id="87884956"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF28">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="9">
        <location>
            <begin position="7"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3307924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="516" mass="57690" checksum="C7064880B9F6BE5F" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M449</accession>
    <name>A0AAJ0M449_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_392339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724121.1">
        <property type="nucleotide sequence ID" value="XM_062864627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M449"/>
    <dbReference type="GeneID" id="87883456"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05289">
        <property type="entry name" value="MDR_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052585">
        <property type="entry name" value="Lipid_raft_assoc_Zn_ADH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43482:SF4">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G06260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43482">
        <property type="entry name" value="PROTEIN AST1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="15"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3308341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="332" mass="35221" checksum="BBD72DA0E3F13C2D" modified="2024-07-24" version="1">MNAIQILGPKTNPTVSLSRFHPLPTPDPHAPNSEILIRVHSAGLTADELTWPELYSASNPMHIPGFEISGVVASLPSTYTGPLSVGDSVSALLHPDRGKGQADYVYARPEELARKPKCLSHAQAAALPIPALTAWEALFKRAWSPRPIPTSGLRVLVTGASGAVGSMVVQLAKKVIGARVVALASGAKHGYLRELGADETVDYTAADWERGVGMKSVDAVFDAAGGEVLARAWATVKDDGVVVTVADPPPVWATDKGAVPRELEGRPGVRYTYFIVSPDSETLGKISGLIAEGTVKPLPVVEFSVDKAVEAWDFARRRGRQGKVVVNFVADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M4H2</accession>
    <name>A0AAJ0M4H2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_380319</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724498.1">
        <property type="nucleotide sequence ID" value="XM_062864247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M4H2"/>
    <dbReference type="GeneID" id="87883076"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35186">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35186:SF4">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3308718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="343" mass="39011" checksum="E613DC3E038E01FC" modified="2024-07-24" version="1" fragment="single">MSGIEIAGIVLGSFPILLKCLNHYRDGFRPLEEWWDFRTHSVAFVDDIRHQMMRYNENLIRLLGPIAANMRDLHDLIRNPTDQRWHDGNLEVPLRQRLGSEYDRFFRIVERMREVVADLEVLLQIDDGTVALLVSPSQGTPWQWYFKRMRISFSREKHRNVRKLAAYNQELHEILGYSERITSASVSDKRVALDLELAESDSRLHAPTRAVGLFGSIRQQACGIYNRLNQRRKYDSTCPPETYAARDAARLNFSPLSISVSGNVLFILGSDSEFPSTTLQQFRINMATGATPAPMPDMSLAQKSALLASVQQALIGDNRATMRQEKPGSLPSLRLQASIPSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M4I0</accession>
    <name>A0AAJ0M4I0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Concanavalin A-like lectin/glucanase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_117956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724542.1">
        <property type="nucleotide sequence ID" value="XM_062861582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M4I0"/>
    <dbReference type="GeneID" id="87880411"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070007">
        <property type="term" value="F:glutamic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13426">
        <property type="entry name" value="Peptidase_G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.700">
        <property type="entry name" value="Peptidase G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000250">
        <property type="entry name" value="Peptidase_G1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038656">
        <property type="entry name" value="Peptidase_G1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536:SF1">
        <property type="entry name" value="ASPERGILLOPEPSIN, PUTAITVE (AFU_ORTHOLOGUE AFUA_7G01200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01828">
        <property type="entry name" value="Peptidase_A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042571128" evidence="1">
        <location>
            <begin position="19"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3308762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="301" mass="30706" checksum="87384E06EF83C873" modified="2024-07-24" version="1">MRSTTLLTLLTSALGASGASLPARPRATPRLLLLHTFSESSPSNARLLAASTESTKGGAILTLGDDGNSPAISSVQGTFRVPHAEIPTSGPTAGNPVGEYAASFWVGIDSARPRPASSPNATCGGSLRAGVDVFWDGTIGGQQSPFAWYQFAPGMGNAVGFGEGFSVSPGDLVRFTLDAGSVLVENFGGNVTCVSGGANNGTRPIKSVRQALPSPSAGLCGTEAAFIVDDPPLVSRPDVPVALANFTSVTFGTRVTLADGSVKDLAGAEVLDVRQQQQGGKLTSCEVVEGKKVKCTRVVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M4R5</accession>
    <name>A0AAJ0M4R5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AN1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_125487</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724768.1">
        <property type="nucleotide sequence ID" value="XM_062861684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M4R5"/>
    <dbReference type="GeneID" id="87880513"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51039">
        <property type="entry name" value="ZF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="AN1-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3308988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="71" mass="8332" checksum="1003A6FCB53F3049" modified="2024-07-24" version="1">MPKKLRCQFEDCKAVAQRISGDCTFCQGHFCSNHRLLEDHKCQNLEDCKREAFEQNAMQLNKERTQVIKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M4X3</accession>
    <name>A0AAJ0M4X3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AP-3 complex subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_123197</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Adaptor protein complex 3 (AP-3) is a heterotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724710.1">
        <property type="nucleotide sequence ID" value="XM_062861655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M4X3"/>
    <dbReference type="GeneID" id="87880484"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030123">
        <property type="term" value="C:AP-3 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017105">
        <property type="entry name" value="AP3_complex_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22781:SF12">
        <property type="entry name" value="AP-3 COMPLEX SUBUNIT DELTA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22781">
        <property type="entry name" value="DELTA ADAPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037092">
        <property type="entry name" value="AP3_complex_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="9">
        <location>
            <begin position="20"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="383"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="774"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="824"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="918"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="974"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="393"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="782"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="891"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="925"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="997"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1032"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1045"/>
            <end position="1055"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR037092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3308930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1068" mass="117137" checksum="D856A5C84F184C24" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M673</accession>
    <name>A0AAJ0M673_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">MAP kinase kinase kinase</fullName>
            <ecNumber evidence="11">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0T15DRAFT_481782</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Activates the PBS2 MAP kinase kinase by phosphorylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with by SSK1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="11"/>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726179.1">
        <property type="nucleotide sequence ID" value="XM_062866052.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87884881"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038066">
        <property type="term" value="P:p38MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051403">
        <property type="term" value="P:stress-activated MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06626">
        <property type="entry name" value="STKc_MEKK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000482">
        <property type="entry name" value="MAP kinase kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017240">
        <property type="entry name" value="MAPKKK_Ssk2/Ssk22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF32">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037579">
        <property type="entry name" value="MAPKKK_SSK22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="1051"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="182"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1330"/>
            <end position="1363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1332"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="1080"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00065095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR037579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3310399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1363" mass="154110" checksum="042C0D0D59705AB2" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M6Z2</accession>
    <name>A0AAJ0M6Z2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="5">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_564983</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="5"/>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727151.1">
        <property type="nucleotide sequence ID" value="XM_062870655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M6Z2"/>
    <dbReference type="GeneID" id="87889484"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18785">
        <property type="entry name" value="SF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF120">
        <property type="entry name" value="BIFUNCTIONAL 3'-5' EXONUCLEASE_ATP-DEPENDENT HELICASE WRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="33"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="212"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="351"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="614"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="634"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="691"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3311371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="703" mass="78953" checksum="100A1B9BAA31358B" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M780</accession>
    <name>A0AAJ0M780_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_409636</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727393.1">
        <property type="nucleotide sequence ID" value="XM_062865355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M780"/>
    <dbReference type="GeneID" id="87884184"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF31">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN YCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="64"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3311613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="349" mass="37387" checksum="A84B0B9353A0BD53" modified="2024-07-24" version="1">MVFASPPDPDNSTAIIDFMRQTWLGNAPATNGTTTVSGTWTIAGTYCAPPPGQAKKLAHSTLQVLIHGITYNHSMWAGMGFPFSSDADAEDHIYNWHAYANSRGYATLALDRLGHGASPQRPDPLSVVQPQLQVEILHQIVAAARSGSSAYNVLQTAFERVVIVGHSYGSYVGAALAAQHPADAEAVVLTGYSNYYDFSDVINAEWRAAAEHDPARLGASLPKGYVTMARVEDRVASMYAGAYDPAIPPVDFEGEDTLTVGEIGALGAILGDAVGYGGHVLVVTSVDDAFFCQAPKDKCEAHLASTASSFPDAASYEFFAPEDTGHDLTLHYSSTETFERVHDWLDEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M7C3</accession>
    <name>A0AAJ0M7C3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_508087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727317.1">
        <property type="nucleotide sequence ID" value="XM_062867691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M7C3"/>
    <dbReference type="GeneID" id="87886520"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3311537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="109" mass="12438" checksum="5F65086D6008F622" modified="2024-07-24" version="1">MTHLRLLPRYLAARAFLCVAFYPGQPGIVLDHVSRLLQRRPHTVILSRRCDLLGGSSRRPSNHIFLSLPDMQDTHGIIQRRCYHIPSKQNRPRATSVASRIGPDFLNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GKH9</accession>
    <name>A0AAJ0GKH9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_505856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717399.1">
        <property type="nucleotide sequence ID" value="XM_062867542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GKH9"/>
    <dbReference type="GeneID" id="87886371"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051959">
        <property type="entry name" value="PAK1-Kinase_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44675:SF1">
        <property type="entry name" value="P21-ACTIVATED PROTEIN KINASE-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44675">
        <property type="entry name" value="PAK1 INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3301619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="506" mass="55150" checksum="2347A97E00DADFE8" modified="2024-07-24" version="1">MAKRKREAAAEGEHAEAKTSTKKAKGASKVPKSAAFKLSDGHPVTIQIIAGSYDRVLHGITATVKQTSISAVSKSTSEPQSKPEDNSSSSQHAEFADTFLFNAHNSAIRCLALSPPSAPTPGQSQKILLATGSTDERINIYNLSAHPPSTRAADDQKLLSSLAPRPILENPKNRELGTLLHHSSNITRLVFPNRSKLLSAAEDSTIAVTRTRDWTLLHTFKSPIPKMQGRPSGDTAAQGAAPSGVNDFAVHPSNKIMISVSKGERCMRLWNLETGKKSRVLNFDRAVLAEIGEGRHSTGEARRIVWGSSRGGEDEFAVGFDRDVLVFGMDCVPRCRLMRDTRTKLHEFCYVETDQDKEESLLAVSTEDGRLLFFSTAKEDLGEPLKDKMLPVAKLVAQLGGKEAGVSGRIKDFTILLVEDEGGKKAFFVVTAGSDGRIRLWHLVKDDLSVDNSTAKQVGKLLGTYETQNRITCVEAFVMIPRPQGAEESEFEYESGEEGSEDSDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GKU6</accession>
    <name>A0AAJ0GKU6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Crh-like protein</fullName>
            <ecNumber evidence="15">3.2.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">B0T15DRAFT_323409</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Dual chitinase/transglycosylase that plays a role in cell wall architecture. Chitinase and transglycosylase activities are coupled. Required for the polysaccharide cross-linking at the septa and the cell wall. More specifically, transfers chitin to 1,6-beta-glucan in the cell wall.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the glycosyl hydrolase 16 family. CRH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.-.-" evidence="15"/>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717561.1">
        <property type="nucleotide sequence ID" value="XM_062864076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GKU6"/>
    <dbReference type="GeneID" id="87882905"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000159">
        <property type="entry name" value="Glycosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017168">
        <property type="entry name" value="CHR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF22">
        <property type="entry name" value="GLYCOSIDASE CRH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037299">
        <property type="entry name" value="Glycosidase_CRH1_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042504609" description="Crh-like protein" evidence="18">
        <location>
            <begin position="21"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="19">
        <location>
            <begin position="89"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="338"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="349"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="365"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="377"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="387"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="16">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="16">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00093308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR037299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR037299-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAK3301781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="453" mass="47695" checksum="72560B220359E209" modified="2024-07-24" version="1">MVRSLLPLGAALLGATAVLAADIPTCSLDKKCPKEAPCCSQYGQCGVGAYCLGGCDPRMSFSLDSCVPEPVCQSKTYKMDSLDRYKDIAEYLGDPSEADWVGQGEPVVYNGNVLLTMPPKSVGTVLATSTYLWYGNVKAKLKTSRGRGVVTAFILLSDVKDEIDYEFVGVDLSTAQTNYYFQGIPNYDQSFNITELSNTYDEFHEYEIQWTPDEIKWLVDGKLGRTKKRAETWNETAQQWDYPQTPARVQISIWPGGLESNAKGTIDWAGGVIDWNSQEIKDYGYYFATFGEITVECYNAKSAPGTNKGKSYYYNDISATNNTVVDSDKPTILKSFLGTGTDMNKGETTKSGSATASASSVNAIPGGGSAPGGQIPGAGNADTNAGSGSGSSSGSSGGSSAGTVSGCAATGFAQSCNDGNAAGSNSNSGAVRERTLGASAFAGIVGFAALLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GL86</accession>
    <name>A0AAJ0GL86_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_505082</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717783.1">
        <property type="nucleotide sequence ID" value="XM_062867521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GL86"/>
    <dbReference type="GeneID" id="87886350"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF45">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="145"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3302003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="383" mass="44022" checksum="770195A6D4E8D2DD" modified="2024-07-24" version="1">MFFSICISHLIPPLSSVSALHPEQVHIFRLWQTYLENVNPLLKVTHSSMLQARIIDAVSELGRDIHPTFEALMFSIYCIAVVSLADSECPRLLKSSKEDLLSRYRFACQQLLVKCRPWQFTDIDGLTALYLYLVSEWPQTDPRSLSSMLAASIRIAQRMGFHDESTYTRHTTVEAEMRRRLWWSLVVFDHRICEMSDYKATTLTPTRDCRIPSNRRCFAVIRSELADLIRHSTFHINLVNPVLAAVAKAKDLRDMSVPANGENEMSTIQKAIQAKYLAFCDPADPLHYLTIWTTRGYLPARNRLPEHYARYVTSPATTQQADSQRNAALSYALEMLDCDTRLRVSPLTHFHVPALAYIHVLSDLKRRPRESHAEKAWQVMSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GL90</accession>
    <name>A0AAJ0GL90_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Potassium transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0T15DRAFT_288066</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TrkH potassium transport family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3301978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717758.1">
        <property type="nucleotide sequence ID" value="XM_062863673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GL90"/>
    <dbReference type="GeneID" id="87882502"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140107">
        <property type="term" value="F:high-affinity potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004773">
        <property type="entry name" value="K/Na_transp_Trk1/HKT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015958">
        <property type="entry name" value="Trk1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051143">
        <property type="entry name" value="TrkH_K-transport"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00934">
        <property type="entry name" value="2a38euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064:SF30">
        <property type="entry name" value="HIGH-AFFINITY POTASSIUM TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064">
        <property type="entry name" value="POTASSIUM TRANSPORT PROTEIN DDB_G0292412-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002450">
        <property type="entry name" value="K+_transpter_TRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="4 10" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="424"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="466"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="495"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="558"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="623"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="683"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="733"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="167"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="268"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="788"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="791"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="862"/>
            <end position="873"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR002450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3301978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="888" mass="98613" checksum="43783F964E52D000" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GLC4</accession>
    <name>A0AAJ0GLC4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DRBM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_440107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717843.1">
        <property type="nucleotide sequence ID" value="XM_062865902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GLC4"/>
    <dbReference type="GeneID" id="87884731"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="163"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3302063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="38930" checksum="6192F1CB20EFC406" modified="2024-07-24" version="1">MASNVAVASPSLLDEPVDYRDLKEWIAQQEINPKPLTPVQQRAIADLKRSLEPDLGGRDWVTLLNLFSQATGAASEFTEDLADNGGWACQCNLRLSAETEQMVFPNQAAGFVVGETGTRCAPGFARKKDAKQWAAKCCVEWLMANGHMPSDGKSVTFPKSKAKSPAKAAAQPTKQPASTAATTTITGNTNGYNNTTTSTTITPKKRTHSSSETTNPVDIIKDEDDVPATRRVTQLCQQLGIITPQYRITPTLTTMTTTATSTDSGSGSGSAYFDGYPDFGADSVKVPDGLGRVANVYGRKNTRERIAEEVLAWLVAEEKRRGAELAGLLALTQQAQNGNGNGNGNGNGNGNGNGNGNGNGNGEEGACL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GLP4</accession>
    <name>A0AAJ0GLP4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_422194</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718024.1">
        <property type="nucleotide sequence ID" value="XM_062865566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GLP4"/>
    <dbReference type="GeneID" id="87884395"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051228">
        <property type="term" value="P:mitotic spindle disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071630">
        <property type="term" value="P:nuclear protein quality control by the ubiquitin-proteasome system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19519">
        <property type="entry name" value="RecA-like_CDC48_r1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19528">
        <property type="entry name" value="RecA-like_CDC48_r2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000004">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.330.10:FF:000001">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000003">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000012">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000048">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005938">
        <property type="entry name" value="AAA_ATPase_CDC48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01243">
        <property type="entry name" value="CDC48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02359">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01072">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CDC48 N-terminal subdomain" evidence="7">
        <location>
            <begin position="43"/>
            <end position="126"/>
        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00006914"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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            <dbReference type="SMART" id="SM01073"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3302244.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
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    </evidence>
    <sequence length="822" mass="90320" checksum="AEFF18809E759409" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GM62</accession>
    <name>A0AAJ0GM62_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin cytoskeleton-regulatory complex protein PAN1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Actin cytoskeleton-regulatory complex protein pan1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">B0T15DRAFT_306808</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the PAN1 actin cytoskeleton-regulatory complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Actin patch</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PAN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="TreeGrafter"/>
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    <keyword evidence="12" id="KW-0967">Endosome</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00020728"/>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="SAM" id="Coils"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50031"/>
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            <dbReference type="PROSITE" id="PS50222"/>
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        <source>
            <dbReference type="PROSITE" id="PS51082"/>
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    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAK3302472.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GNP1</accession>
    <name>A0AAJ0GNP1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_262799</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718855.1">
        <property type="nucleotide sequence ID" value="XM_062863361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GNP1"/>
    <dbReference type="GeneID" id="87882190"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3303075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="234" mass="25650" checksum="CF3813CFC2FE1417" modified="2024-07-24" version="1">MLRLASRSEGTPASLPESCPTYGLTSLCHSSKVFSATYGYSCVPRTYCFISRTIVLVGAYNIAAITRQLSDLLHSRSTFPSICNRHFPLGDVAFIVFVPLWIQEHQAYSDGGFKPPKAHCICGHASLGSRHSSGAVVTGYTNGSRFGLFHHKRSADAVVHVLLSFTDTRVFRTEEGLGHGTFNIHIRQLDYKPTKWKGMHLAYINSLHPSLVLDGAPIIHVTTNSGLSLKLIHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GNZ5</accession>
    <name>A0AAJ0GNZ5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Membrane bound hemo protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0T15DRAFT_276152</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Microsome membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12 13">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719259.1">
        <property type="nucleotide sequence ID" value="XM_062863519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GNZ5"/>
    <dbReference type="GeneID" id="87882348"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000002">
        <property type="entry name" value="Cytochrome b5 type B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359:SF150">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0492">Microsome</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="15">
        <location>
            <begin position="3"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3303479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="137" mass="14689" checksum="D18BF28257FB6947" modified="2024-07-24" version="1">MASKELTYQDVAEHNTKKDLYVVIHDQIYDCTKFVDEHPGGEEVLLDVAGQDATEAFEDVGHSDEARETLEQLKVGTLKRNPGDPKPKTPLPGAVAPAANNTSAGFGVGLYAVVLIGGLIAYGAYQYLQQQQAAQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GPA5</accession>
    <name>A0AAJ0GPA5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF2433 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_486958</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719371.1">
        <property type="nucleotide sequence ID" value="XM_062866397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GPA5"/>
    <dbReference type="GeneID" id="87885226"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00838">
        <property type="entry name" value="MPP_superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018829">
        <property type="entry name" value="DUF2433"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052743">
        <property type="entry name" value="Glutaminase_GtaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056812">
        <property type="entry name" value="RRM_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987:SF11">
        <property type="entry name" value="DUF2433 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987">
        <property type="entry name" value="GLUTAMINASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10360">
        <property type="entry name" value="DUF2433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25061">
        <property type="entry name" value="RRM_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2433" evidence="2">
        <location>
            <begin position="269"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-binding" evidence="3">
        <location>
            <begin position="503"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="542"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="432"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="479"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="648"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3303591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="667" mass="69871" checksum="E94A996F89BA9151" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GPH8</accession>
    <name>A0AAJ0GPH8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_283482</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the secreted LysM effector family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719543.1">
        <property type="nucleotide sequence ID" value="XM_062863611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GPH8"/>
    <dbReference type="GeneID" id="87882440"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052210">
        <property type="entry name" value="LysM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997">
        <property type="entry name" value="AM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997:SF2">
        <property type="entry name" value="LYSM DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042507926" description="LysM domain-containing protein" evidence="6">
        <location>
            <begin position="22"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="7">
        <location>
            <begin position="151"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="7">
        <location>
            <begin position="232"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="7">
        <location>
            <begin position="311"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="7">
        <location>
            <begin position="388"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3303763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="438" mass="45662" checksum="48DF9C8000BF6C93" modified="2024-07-24" version="1">MLTSVPISLLVSAAVFNVALGAAVGRVVARDGSKPSLSFDPNTTGWCTWWADLNEPTACSTLLPDNNITLEQFRRWNPSVPETCGTLPAGHSYCVEAFYEPVPSSTSTITTTTARITSSTTTPPPTTTTLPGNGVTTPAPIQAGMVGNCNKFHFVEKDQNCATIAALYSISTGQFSQWNPAVKSDCSGLWASTYACVGVLGGSPAPSTTLPANGIATPSPTHPGMMVSNCNKFTKVNPGDSCDGIAFFNGPISTEDFVLWNTGVGGRECRTLQADTYVCVGLIPGGTPTQPGNGIATPAPAHPGMVGNCNKFYKVNAGDSCDSIAFWNGVPGTEWVIRWNAGVGSDCRTLQANTYACIGVIGGTPTQPGNGIATPTPILPGMVDYCKKFTKVNPGDTCDIISFFNGPISTADFIKWNPGVGGQECRGLQAGTYVCIGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQD5</accession>
    <name>A0AAJ0GQD5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_535794</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Autophagosome membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Vacuole membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ATG8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719987.1">
        <property type="nucleotide sequence ID" value="XM_062869521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQD5"/>
    <dbReference type="GeneID" id="87888350"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048646">
        <property type="term" value="P:anatomical structure formation involved in morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16128">
        <property type="entry name" value="Ubl_ATG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000010">
        <property type="entry name" value="Autophagy-related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004241">
        <property type="entry name" value="Atg8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10969">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02991">
        <property type="entry name" value="ATG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="lipid moiety-binding region" description="Phosphatidylserine amidated glycine; alternate" evidence="9">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR604241-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3304207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="121" mass="14098" checksum="C0609DBCEF9E1246" modified="2024-07-24" version="1">MRSKFKDEHPFEKRKAEAERIRQKYSDRIPVICEKVEKSDIATIDKKKYLVPADLTVGQFVYVIRKRIKLSPEKAIFIFVDEVLPPTAALMSSIYEEHKDEDGFLYITYSGENTFGNFETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GRC5</accession>
    <name>A0AAJ0GRC5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_512850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720513.1">
        <property type="nucleotide sequence ID" value="XM_062868008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GRC5"/>
    <dbReference type="GeneID" id="87886837"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3304733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="206" mass="23348" checksum="08B684DF81D18D0A" modified="2024-07-24" version="1">MSHPARRFNPACRYELLWKGLASRHSIVQCSVTKAPNQQFSFPGLTTRPRVFKSRAPHETIGQVQQRRRRHPEGVRHRAIMPTLITTAIGIASARRDQHHAEAIERLWWCALREIIQGPVLRSVSTWALAVAESRRQSTALNFAHLHVISLLCVVAQAAMYRSALLRQPFREGPVLYHPNLNISAILNNTQAHTLQFTKTSKASKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GRC8</accession>
    <name>A0AAJ0GRC8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_537443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720514.1">
        <property type="nucleotide sequence ID" value="XM_062869616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GRC8"/>
    <dbReference type="GeneID" id="87888445"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02208">
        <property type="entry name" value="cupin_RmlC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="1">
        <location>
            <begin position="57"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3304734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="231" mass="26392" checksum="4EA519AEEB76B1AE" modified="2024-07-24" version="1">MVRSWQLWLSPRPLRRTETPVEPRMLSAHDASLYEFIYEADGRLVVQETHYASSKHVRQGASGPPLHIHPRQSEYFQVLQGTLAAVKNEKQVRLTKDDGILAIEPGARHRFWADSSINSTHEDLIFQVRAEPQDVERGFDENFLRNITGYMRDCAQQGVPPSLFQIALFGWAGDTLLICPPFYVPLWILEAAQYVAGHVVGYHLLGYRATYPEYNTKPRERFPGNGTKKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GRV2</accession>
    <name>A0AAJ0GRV2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bromodomain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_400428</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
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                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
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                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
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                <person name="Ng V."/>
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Labutti K."/>
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                <person name="Yanf M."/>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720861.1">
        <property type="nucleotide sequence ID" value="XM_062870366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GS30"/>
    <dbReference type="GeneID" id="87889195"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="739"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="516"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="742"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3305081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="852" mass="94721" checksum="2EA992B7806B0B05" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GSD8</accession>
    <name>A0AAJ0GSD8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_187697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720830.1">
        <property type="nucleotide sequence ID" value="XM_062862402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GSD8"/>
    <dbReference type="GeneID" id="87881231"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3305050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="377" mass="42621" checksum="26AE82067774486B" modified="2024-07-24" version="1">MKTLQYIWVLGDRTLRREEGLGYDDPVPFVTLDEFLQCAHLYETFHQTYQLVFNIHPFRFVREIVRPRRFYPGDFTPKPNLLMEELVTVLTPLLNHILGLTLPSFIRGSTMEDLAAGQYSHGFLARTPEAHSTVCQPDWRSLYFPVLPLMSMMDPTGHVTKNLPRTLWVPFSWIPEPQRKALRLKEPKQKRPALVREWGPNEHQIQLRVGQKSCEPKTRLEPVVGPIQFRGQAQLPPDVADLVAKLKISFDRELPILAVRGPTGSERTLVSVVSVEASIARATSRISASPDRSQPSQASGSTPGRHDDGQVRAPQQLIPPIFPVTKATLPAGILQLTPQQMWGVVVNWYAAQNEARLRWAKDNGKNLDEASFSHPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GSG5</accession>
    <name>A0AAJ0GSG5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_397710</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.n1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the GTP-binding elongation factor family. LepA subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721044.1">
        <property type="nucleotide sequence ID" value="XM_062864919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GSG5"/>
    <dbReference type="GeneID" id="87883748"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097177">
        <property type="term" value="F:mitochondrial ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03699">
        <property type="entry name" value="EF4_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16260">
        <property type="entry name" value="EF4_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01890">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03709">
        <property type="entry name" value="lepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000078">
        <property type="entry name" value="Elongation factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000015">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000007">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2570:FF:000001">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000004">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2570">
        <property type="entry name" value="Elongation factor 4, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00071">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038363">
        <property type="entry name" value="LepA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013842">
        <property type="entry name" value="LepA_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035654">
        <property type="entry name" value="LepA_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01393">
        <property type="entry name" value="lepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512:SF7">
        <property type="entry name" value="TRANSLATION FACTOR GUF1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="TRANSLATION FACTOR GUF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06421">
        <property type="entry name" value="LepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="106"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="115"/>
            <end position="122"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="182"/>
            <end position="186"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="236"/>
            <end position="239"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3305264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="708" mass="78335" checksum="7B9526A2660C1C63" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GSH6</accession>
    <name>A0AAJ0GSH6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Emp24/gp25L/p24 family/GOLD-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_434055</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721113.1">
        <property type="nucleotide sequence ID" value="XM_062865789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GSH6"/>
    <dbReference type="GeneID" id="87884618"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042470515" evidence="8">
        <location>
            <begin position="17"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="9">
        <location>
            <begin position="26"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3305333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="219" mass="24847" checksum="500E5844C6EF3CA7" modified="2024-07-24" version="1">MRTLLPLLSLAAMARALYFYIDVTSPKCFFEELPKDTLVVGHYTAEEWDDRLQAWARHDGIKIYITVDEVFDNDHRVVSQHGASSGKFTFTAADAGDHKLCFTPSSNSGRSNWLSLSSPNGGIRLSLDLAIGETSALEGGDKEKIQDLATRVRDLNARLNDIRREQVFQREREAEFRDQSESTNARVVRWILIQLTVLGVTCAWQLSHLRSFFIKQKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GSI9</accession>
    <name>A0AAJ0GSI9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0T15DRAFT_193928</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721114.1">
        <property type="nucleotide sequence ID" value="XM_062862484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GSI9"/>
    <dbReference type="GeneID" id="87881313"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14127">
        <property type="entry name" value="STKc_CK1_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000160">
        <property type="entry name" value="Casein kinase I 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000538">
        <property type="entry name" value="Putative Casein kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="13"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="301"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="357"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="301"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="393"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="420"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3305334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="446" mass="50037" checksum="8930B6FC0C8A1DD0" modified="2024-07-24" version="1">MASSSSNVVGVHYRVGKKIGEGSFGVIFEGMNLLNSQQVAIKFEPRKSDAPQLRDEYRTYKILVGCPGIPNVYYFGQEGLHNILVIDLLGPSLEDLFDHCNRRFSLKTVVMVAKQMLSRVQTIHEKNLIYRDIKPDNFLIGRPGTKTANVIHVVDFGMAKQYRDPKTKQHIPYRERKSLSGTARYMSINTHLGREQSRRDDLEALGHVFMYFLRGGLPWQGLKAATNKQKYEKIGEKKQTTPIKDLCEGFPEQFAHYLTYVRNLGFEDTPDYDYLRDLFTQALKEEGGVEDGEYDWMKKQDKKGDWNRQPLHDPNSRPGPSAMEIHGNSRGNTTRHQSDPQAPGLTAARLNATQPPLPRQAIGQSQKQGRPNGPGLASPRSAVGGYMAAAPTPTGSTQAQFQNSNQNLPQRPMTQSPQMNTPAQPQNSAQPQPTGFQKFMKTLCCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GSU4</accession>
    <name>A0AAJ0GSU4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_531858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721070.1">
        <property type="nucleotide sequence ID" value="XM_062869281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GSU4"/>
    <dbReference type="GeneID" id="87888110"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3305290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="152" mass="16915" checksum="9F75AF1401701EE6" modified="2024-07-24" version="1">MSEKLAAWTQRPGVFAATALVNLSELTDVELDAPVARTSISRPCSADLDARHGGKARSPQRNHASHEHTWQLIHALHSGHDHLRRHRPKADFRFTLQTEHVRVPYRFNLQKTSLARDPGSAESAVQTTAPTRVAGPRVLVSPIDYVSTKNYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GT87</accession>
    <name>A0AAJ0GT87_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cornichon protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_511576</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cornichon family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721462.1">
        <property type="nucleotide sequence ID" value="XM_062867921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GT87"/>
    <dbReference type="GeneID" id="87886750"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003377">
        <property type="entry name" value="Cornichon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12290">
        <property type="entry name" value="CORNICHON-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03311">
        <property type="entry name" value="Cornichon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01398">
        <property type="entry name" value="Cornichon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3305682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="179" mass="20862" checksum="24CDDFA2452E12B5" modified="2024-07-24" version="1">MSGEAWLYLFAVIINAVNLFLQVFFTIMYSDLEWYGFPGQQQLVNLDGWRQAISASNGRWLARLRQAHYCLVLGSDYINPIDLCNRLNTYIIPEVAVHGFLTFLFLINGYWLPLILNLPLLGWNVKKIVDNTHLLDATEIFRKLNVHKKESFTKLGFHLVLFFFYLYSMIVALIKDEAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GTA1</accession>
    <name>A0AAJ0GTA1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Conserved oligomeric Golgi complex subunit 6</fullName>
            <shortName evidence="10">COG complex subunit 6</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 10">Component of oligomeric Golgi complex 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0T15DRAFT_416049</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Acts as a component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the conserved oligomeric Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the COG6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721270.1">
        <property type="nucleotide sequence ID" value="XM_062865466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GTA1"/>
    <dbReference type="GeneID" id="87884295"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010490">
        <property type="entry name" value="COG6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048369">
        <property type="entry name" value="COG6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048368">
        <property type="entry name" value="COG6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21506">
        <property type="entry name" value="COMPONENT OF OLIGOMERIC GOLGI COMPLEX 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21506:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20653">
        <property type="entry name" value="COG6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06419">
        <property type="entry name" value="COG6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01087">
        <property type="entry name" value="COG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric complex COG6 N-terminal" evidence="13">
        <location>
            <begin position="51"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved Oligomeric Golgi complex subunit 6 C-terminal" evidence="14">
        <location>
            <begin position="195"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="536"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF20653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3305490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="691" mass="76986" checksum="327A6BF36A5F1040" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GTA7</accession>
    <name>A0AAJ0GTA7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0T15DRAFT_207091</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721501.1">
        <property type="nucleotide sequence ID" value="XM_062862632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GTA7"/>
    <dbReference type="GeneID" id="87881461"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20346">
        <property type="entry name" value="BRcat_RBR_ANKIB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20356">
        <property type="entry name" value="Rcat_RBR_HHARI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16625">
        <property type="entry name" value="RING-HC_RBR_HEL2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1750:FF:000007">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000019">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045840">
        <property type="entry name" value="Ariadne"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048962">
        <property type="entry name" value="ARIH1-like_UBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
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    </dbReference>
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        <source>
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        <source>
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        </source>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3305721.1"/>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        <lineage>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="GeneID" id="87888188"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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            <end position="64"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ0GTK2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_212729</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
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                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721639.1">
        <property type="nucleotide sequence ID" value="XM_062862694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GTK2"/>
    <dbReference type="GeneID" id="87881523"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3305859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="226" mass="25208" checksum="8CEB93A96DFA42E0" modified="2024-07-24" version="1">MSRFVLPPLSCQLTCLRRRDTLSASLTHRLLSKSDISAPSDCWHCSHISTIAPFFWPAACSGPVAKASGGSLSLDENMRGEKERKTRESMFGDVGQLCLETVQQCPPMSSRKTAFISLMLVASPSPDYALHNTAQKPYFLPWSSNRGNNPGTDSMMRRFKPRLASPAREALPTYGLPRIVGLSYPLSPTLLQSLCVWPLSLFRILLFFSIRYRHHHIHCLAVASCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GTP2</accession>
    <name>A0AAJ0GTP2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_511785</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721699.1">
        <property type="nucleotide sequence ID" value="XM_062867936.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87886765"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000019">
        <property type="entry name" value="Polyketide synthase type I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF20">
        <property type="entry name" value="HYBRID PKS-NRPS SYNTHETASE APDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22621">
        <property type="entry name" value="CurL-like_PKS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="9">
        <location>
            <begin position="8"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="10">
        <location>
            <begin position="965"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="2346"/>
            <end position="2423"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="6">
        <location>
            <begin position="965"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="6">
        <location>
            <begin position="1113"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2427"/>
            <end position="2466"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="6">
        <location>
            <position position="997"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="6">
        <location>
            <position position="1172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3305919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="2466" mass="271004" checksum="5C6665AA91EF8C74" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GTV3</accession>
    <name>A0AAJ0GTV3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_534135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3306038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721818.1">
        <property type="nucleotide sequence ID" value="XM_062869420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GTV3"/>
    <dbReference type="GeneID" id="87888249"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40129">
        <property type="entry name" value="KETOPANTOATE REDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40129:SF2">
        <property type="entry name" value="KETOPANTOATE REDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3306038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="312" mass="34375" checksum="B20B834120D0D7A4" modified="2024-07-24" version="1">MEEKSLLILGAGWTATFLIPLLQSRNIPFAATTTDGRIVAGAPTIPFKFNPTAPEEETRSAIASLPYARHVLITFPLTGPGQSKLLVECYEETHRRAVSAMSVGATSSPAARARARFIQLGSTGIWQQPRQRQRLQPGADGGKGPWMTRHSPYTTTDPRAVAEDELLSLGGCVLDLAGLWGGARDPRHWIGRVASTKEALREKKSLHMVHGLDVARGVVAVVTGGDEKWEKHGRGQRWMVTDGFVYDWWALMAGWAEGEGVSEPIDQARWVFELMNEEGVKALPRSMEALGRCYDSREFWEAFGLVPLKGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GTY5</accession>
    <name>A0AAJ0GTY5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA cytidine acetyltransferase</fullName>
            <ecNumber evidence="9">2.3.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">18S rRNA cytosine acetyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">NAT10</name>
        <name evidence="15" type="ORF">B0T15DRAFT_434982</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein TAN1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a cytidine in 18S rRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in 18S rRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51424"/>
            <dbReference type="Rhea" id="RHEA-COMP:13575"/>
            <dbReference type="Rhea" id="RHEA-COMP:13576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a cytidine in tRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in tRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53876"/>
            <dbReference type="Rhea" id="RHEA-COMP:13670"/>
            <dbReference type="Rhea" id="RHEA-COMP:13671"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with TAN1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="9"/>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GTY5"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990883">
        <property type="term" value="F:18S rRNA cytidine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904812">
        <property type="term" value="P:rRNA acetylation involved in maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051391">
        <property type="term" value="P:tRNA acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11040:FF:000002">
        <property type="entry name" value="RNA cytidine acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03211">
        <property type="entry name" value="RNA_acetyltr_Nat10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033688">
        <property type="entry name" value="NAT10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007807">
        <property type="entry name" value="TcmA/NAT10_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032672">
        <property type="entry name" value="TmcA/NAT10/Kre33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013562">
        <property type="entry name" value="TmcA/NAT10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027992">
        <property type="entry name" value="tRNA_bind_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925">
        <property type="entry name" value="N-ACETYLTRANSFERASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925:SF5">
        <property type="entry name" value="RNA CYTIDINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13718">
        <property type="entry name" value="GNAT_acetyltr_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05127">
        <property type="entry name" value="NAT10_TcmA_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08351">
        <property type="entry name" value="TmcA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13725">
        <property type="entry name" value="tRNA_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TmcA/NAT10 N-terminal" evidence="12">
        <location>
            <begin position="10"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="TcmA/NAT10 helicase" evidence="11">
        <location>
            <begin position="283"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="13">
        <location>
            <begin position="539"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="domain" description="Possible tRNA binding" evidence="14">
        <location>
            <begin position="774"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1011"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="449"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1054"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="638"/>
            <end position="640"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="645"/>
            <end position="651"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="739"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3305790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1065" mass="118320" checksum="247F45E9C8B9D08E" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GU83</accession>
    <name>A0AAJ0GU83_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial division protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_217342</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in mitochondrial fission. Acts as an adapter protein required to form mitochondrial fission complexes. Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat MDV1/CAF4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3306055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721835.1">
        <property type="nucleotide sequence ID" value="XM_062862755.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87881584"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="14"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 7" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="462"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="488"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="NACHT" evidence="10">
        <location>
            <begin position="66"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="702"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="744"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="786"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="828"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="870"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="912"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="954"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="996"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="1038"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="1080"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="1121"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="1163"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="1205"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="1247"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3306055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1385" mass="151912" checksum="E0B667C496ABA775" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GUI0</accession>
    <name>A0AAJ0GUI0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleolar protein 56</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_398025</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3306090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721870.1">
        <property type="nucleotide sequence ID" value="XM_062864934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GUI0"/>
    <dbReference type="GeneID" id="87883763"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000001">
        <property type="entry name" value="Nucleolar protein 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012974">
        <property type="entry name" value="NOP58/56_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08156">
        <property type="entry name" value="NOP5NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Nop" evidence="7">
        <location>
            <begin position="302"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="455"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="455"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="473"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="483"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="511"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3306090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="522" mass="57931" checksum="396B4E9F98FD4DCD" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GUY3</accession>
    <name>A0AAJ0GUY3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_146945</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722388.1">
        <property type="nucleotide sequence ID" value="XM_062861943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GUY3"/>
    <dbReference type="GeneID" id="87880772"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3306608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="366" mass="41393" checksum="03B8617B4948A371" modified="2024-07-24" version="1">MHWESGKRSASAIHLQELLSELKRASPELCPVFTGGWTTPAQYVQPLGMKPLRFSINTRKVSTMTYGSSCLRRAVAGHLLLAPLLTVLGSILSLLSSQARLQLQSLPPFWAFPLLRFWYRIHLNRGQKDIFLSTELDKMYWLKNLITFSLSTILILNLAIPLALFASIITFCSWAYLTGYLIWAFIEHIIMFVPRTILFRWRMDERNLTRFNNVVSVPKAADPDSFRPVSPGRFPPLPSYLRSDHTPPKRRLSNTALGGRLSGPELRAWLMRDYEGLGGPKWDDLDESPLPTMKRQRTHADSGVGSSRTAQSGSKGVSPRTFGTVLSPRRLTIVDNMHRTGRVPPTIVEGDSDEERSKTPTRSLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GV96</accession>
    <name>A0AAJ0GV96_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_154294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722588.1">
        <property type="nucleotide sequence ID" value="XM_062862030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GV96"/>
    <dbReference type="GeneID" id="87880859"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF27">
        <property type="entry name" value="PHO85 CYCLIN CLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3306808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="346" mass="38996" checksum="4174C744B655CD2D" modified="2024-07-24" version="1">MPGGVCAVLDYEVELMADYVSEMATRVVMPHRQVNPAFRKFVSQILTSTRLPSTTILLAMNYLAKRINMMHAAGQTNHTEGQIWRMLTIALLLGSKFLDDNTFQNKSWSEVSGIPVQELNTLEYEWLGAIRWCLYVNLDASKDYQAWLSNWKQWQEAKKRQQQEASRDRLAGLVSPIEPDTRSRAQQLYSAWHQQQVAEYERLSSMKRNQAPMGASFRHEPSSWAYPPPSWSQTAPLTPPDSGYGTPEYTNSTTLATSNYTEWLDGALLGANATSRHYQQPAPYSGFRHNGHGSRHAVGYGHYYGYGHNIWEQPSVADCNCGLCAGVHNKVPAYFGGHHYSQAVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GVC4</accession>
    <name>A0AAJ0GVC4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="9">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_152052</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Lipid-anchor</topology>
            <topology evidence="1 9">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="9"/>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722542.1">
        <property type="nucleotide sequence ID" value="XM_062862008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GVC4"/>
    <dbReference type="GeneID" id="87880837"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF5">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 9" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042318236" description="1,3-beta-glucanosyltransferase" evidence="9">
        <location>
            <begin position="19"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="384"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="406"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3306762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="464" mass="49461" checksum="F42C89B9727DAAE0" modified="2024-07-24" version="1">MKSAVLVSALTAAVTVHGGPTATLPVKPRQVELEPITATGNAFFKGKQRFYVRGIDYQPGGASANIDPLADTEVCMPDIEKFKKLGINTIRVYSTDNSVDHDECMNALAEAGIYVVLDANNPKYSINREDPHGSYNTPYLQSVFATIDAFAKYPNTMAFFSGNEVIHDLANTTLAAPYVKATDRDMRAYIKARGYRKILVGYSAADVSTNRRQTADYFNCGSDDERSDFFAFNDYSWCSSDFITAGWDKKVQNFTGYGLPIFLSEYGCNHNTRDFGEVESLMHSNMTGVYSGGLMYEYTMEANKFGIVEIEGGQENGGKDQTGKRKELPEFAAYQSALKKFPAPSGDGGFTSSTKAAACPTQDENWSVSSTALPAIPEGAKKFFEEGAGKGPGLNGPGSQWAVDQASTSEGPSAGSSTSGGSGSSGSSNPSSAAVRATVPAMSKAPIVVSGLVVLFTLVGAVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GVQ2</accession>
    <name>A0AAJ0GVQ2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed RNA polymerases I, II, and III subunit RPABC3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_484182</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the eukaryotic RPB8 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722724.1">
        <property type="nucleotide sequence ID" value="XM_062866212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GVQ2"/>
    <dbReference type="GeneID" id="87885041"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000191">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005570">
        <property type="entry name" value="RPABC3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10917">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10917:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03870">
        <property type="entry name" value="RNA_pol_Rpb8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000779">
        <property type="entry name" value="RNA_pol_Rpb8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00658">
        <property type="entry name" value="RPOL8c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3306944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="151" mass="17295" checksum="41285AA3F923C014" modified="2024-07-24" version="1">MSGISSDAQLFEDHFRVERLSEPKYDRVDRIYCKSDDKSIIMSLDINKELFPCKVDDELHVALATSLHYDGSKDDERGWRDVAKAGASDATLADIFDYVCYGKIYKFEDAEDGKTIKAYISFGGLLMSLEGPYKKLTPLRVDYVYLLVRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GW33</accession>
    <name>A0AAJ0GW33_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_394709</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722973.1">
        <property type="nucleotide sequence ID" value="XM_062864744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GW33"/>
    <dbReference type="GeneID" id="87883573"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="234"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3307193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="368" mass="41055" checksum="15A834A7547F552B" modified="2024-07-24" version="1">MSASGPASAPDVGNNLPPQNVTTTTTTITARTFPPLGVVLSESTFSLWKEKFLRTLQRNGLLDYIENDVPEPAERQAKLQWINNRADIQEFIETYMTSDIQQILAASGWNVRQFDLKGTLEKLEALITDRPGDYHCQLAKELANIRRENFDSMTAFTTCIAELRNALKNSDICKVTDKGVTLFALRGIEQEYPEVAQRARVGVEAGTYTWEAMIREFSLIAKNETVNLGLAAVKSDNNGNNSNKGGKSDKKKGDNRADCDVCGRKQAKKAKHCKDCDNHHKGDICWYCHPEEAPDSWAKKQEYLEKKKKKQGKGSTTAPLHQQSGVANPTDSNIKVIDNNGKKVFFTTSNFVMTAMSPSHFQEGSQHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GW85</accession>
    <name>A0AAJ0GW85_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NB-ARC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_414325</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723048.1">
        <property type="nucleotide sequence ID" value="XM_062865439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GW85"/>
    <dbReference type="GeneID" id="87884268"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056681">
        <property type="entry name" value="DUF7779"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25000">
        <property type="entry name" value="DUF7779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="54"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7779" evidence="3">
        <location>
            <begin position="629"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="865"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3307268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="865" mass="96804" checksum="FA128C9D1D1585D7" modified="2024-07-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GWC8</accession>
    <name>A0AAJ0GWC8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Peptide hydrolase</fullName>
            <ecNumber evidence="14">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0T15DRAFT_175155</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Extracellular aminopeptidase that allows assimilation of proteinaceous substrates.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the peptidase M28 family. M28E subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="14"/>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723158.1">
        <property type="nucleotide sequence ID" value="XM_062862250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GWC8"/>
    <dbReference type="GeneID" id="87881079"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03879">
        <property type="entry name" value="M28_AAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000042">
        <property type="entry name" value="Peptide hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF56">
        <property type="entry name" value="AMINOPEPTIDASE YDR415C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 14" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <keyword evidence="8 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042315631" description="Peptide hydrolase" evidence="14">
        <location>
            <begin position="19"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="15">
        <location>
            <begin position="177"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3307378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="406" mass="45366" checksum="305AEBD54D13F7AA" modified="2024-07-24" version="1">MKVSNASLLAVLLPAVSARFAEPGEPDRVILYPHGIPNSPEESQQHHIELAPGETRWVTEDEKWELRRNGIRFFDITDNADLGALRARSATKKKSVFPEKPKLQKEIKPLLAKLSKTEMKDHLTTFTSFHTRYYKSDYGRQSSEWLLGQVRDTIKSAGAEKYVHAEHFKHPWGQNSIIATIPGKTNSTIVIGAHQDSINLWLPSVLAAPGADDDGSGTVTILEAFRVILQSEDIVKGKHENTLEFHWYSAEEGGLLGSQAIFSTYEKQGRDVKAMLQQDMTGFVRRTLDAGKPESVGVIVDYVDPNLTDFVKKVIVEYCDIPFVETKCGYACSDHASASKAGYPSAFVIESAFEFSDDHIHSTEDLIKYLSFDHMLQHARMTLAFGYELAFTDFSVLEGPDHSDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GWD8</accession>
    <name>A0AAJ0GWD8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mitochondrial fission process protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Mitochondrial 18 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_393261</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MTFP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723084.1">
        <property type="nucleotide sequence ID" value="XM_062864679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GWD8"/>
    <dbReference type="GeneID" id="87883508"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019560">
        <property type="entry name" value="Mitochondrial_18_kDa_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11001">
        <property type="entry name" value="MITOCHONDRIAL FISSION PROCESS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11001:SF2">
        <property type="entry name" value="MITOCHONDRIAL FISSION PROCESS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10558">
        <property type="entry name" value="MTP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3307304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="302" mass="33667" checksum="9B60D02C9045DF08" modified="2024-07-24" version="1">MWWPWSSSDKPTGPSTQQNDISTPSSRTERARDDLKDAAGLNPNKPSDREKLPPKLQKIIDKSDKEDNIFDELVEGYAPPSTESNVRYAAYAARFRTILLSAHRYVAYTSDIGESFRPVAHPWLVRGAYGVSWAYILGDVSYEGYKAYWHNQRVLNPQVELTTRQQQMLGIDLTSTAGSPAPAAPGTVPPLEDYRTVMLQRGIFQSIASMGLPAFTIHSVVRYSGRAMKDVKNAKLRTWGPIGLGLAVVPFLPTIFDKPVENAVEWVFHKGFESYGGREAVGNAPLIGREKQLSEKPKKKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GWJ1</accession>
    <name>A0AAJ0GWJ1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_530287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723248.1">
        <property type="nucleotide sequence ID" value="XM_062869163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GWJ1"/>
    <dbReference type="GeneID" id="87887992"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990444">
        <property type="term" value="F:F-box domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062026">
        <property type="term" value="P:negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070372">
        <property type="term" value="P:regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052449">
        <property type="entry name" value="STYX-Interacting_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46588">
        <property type="entry name" value="SERINE/THREONINE/TYROSINE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46588:SF1">
        <property type="entry name" value="SERINE_THREONINE_TYROSINE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3307468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="322" mass="33849" checksum="6637CDABB7023ACA" modified="2024-07-24" version="1">MYYHPTQPSALAIAPYTIRVPSPPHIVVPPLSAPGGLTNSFPADDDDGFDAREHYDHDGLSDVMTITPSPNASHVTGLTRDEVHLITAGGPVAAAGVQTARGRGAYGWVYEARRRAQPVLDYLYLGPAGAAKDRAFLAREGITMVLCARDPRFGDLMVNGVRRAVEGLGGRGGGGEGGDAPVEVEAVDVVFDGAARLMGAFAGALQRINAHVLAVNSRAAAEGTGRRGKVLVVCETGNDWSAAAVVAYLMAMYGLDTVRAVQYVQLQRLAKGQVGAMATFSNQFGSGGGLGGNSKRRIEVTRDEDGEERAGRAFAPFVERDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GWN5</accession>
    <name>A0AAJ0GWN5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nuclear GTPase SLIP-GC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_530475</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723306.1">
        <property type="nucleotide sequence ID" value="XM_062869173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GWN5"/>
    <dbReference type="GeneID" id="87888002"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056024">
        <property type="entry name" value="DUF7605"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36681">
        <property type="entry name" value="NUCLEAR GTPASE, GERMINAL CENTER-ASSOCIATED, TANDEM DUPLICATE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36681:SF3">
        <property type="entry name" value="NUCLEAR GTPASE, GERMINAL CENTER-ASSOCIATED, TANDEM DUPLICATE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24564">
        <property type="entry name" value="DUF7605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin N-terminal" evidence="3">
        <location>
            <begin position="94"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7605" evidence="4">
        <location>
            <begin position="743"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="423"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="989"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1021"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="375"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="434"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="455"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="467"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3307526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1041" mass="115129" checksum="6424CA0EF303EBE2" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GX37</accession>
    <name>A0AAJ0GX37_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Sulfite reductase [NADPH] subunit beta</fullName>
            <ecNumber evidence="6">1.8.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">B0T15DRAFT_493158</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Catalyzes the reduction of sulfite to sulfide, one of several activities required for the biosynthesis of L-cysteine from sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>hydrogen sulfide + 3 NADP(+) + 3 H2O = sulfite + 3 NADPH + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>siroheme</name>
            <dbReference type="ChEBI" id="CHEBI:60052"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sulfur metabolism; hydrogen sulfide biosynthesis; hydrogen sulfide from sulfite (NADPH route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="19">Alpha(2)-beta(2). The alpha component is a flavoprotein, the beta component is a hemoprotein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.2" evidence="6"/>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723472.1">
        <property type="nucleotide sequence ID" value="XM_062866924.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87885753"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009337">
        <property type="term" value="C:sulfite reductase complex (NADPH)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050311">
        <property type="term" value="F:sulfite reductase (ferredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004783">
        <property type="term" value="F:sulfite reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000007">
        <property type="entry name" value="Pyruvate:ferredoxin (Flavodoxin) oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.413.10:FF:000003">
        <property type="entry name" value="Sulfite reductase [NADPH] hemoprotein beta-component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.413.10:FF:000004">
        <property type="entry name" value="Sulfite reductase [NADPH] hemoprotein beta-component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000051">
        <property type="entry name" value="Sulfite reductase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.480.20:FF:000012">
        <property type="entry name" value="Sulfite reductase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000016">
        <property type="entry name" value="Sulfite reductase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.480.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="entry name" value="Sulfite Reductase Hemoprotein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01540">
        <property type="entry name" value="CysI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011786">
        <property type="entry name" value="CysI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045169">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02041">
        <property type="entry name" value="CysI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010029">
        <property type="entry name" value="PRK13504.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11493:SF47">
        <property type="entry name" value="SULFITE REDUCTASE [NADPH] SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11493">
        <property type="entry name" value="SULFITE REDUCTASE [NADPH] SUBUNIT BETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="Nitrite and sulphite reductase 4Fe-4S domain-like"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="Nitrite/Sulfite reductase N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00365">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="16" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0349">Heme</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="22">
        <location>
            <begin position="790"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="239"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="245"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012604"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00052219"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00057613"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00063391"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00067595"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3307692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1529" mass="169104" checksum="8E86DB72E9C5BC42" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GX81</accession>
    <name>A0AAJ0GX81_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RelA/SpoT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_84516</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3307767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723547.1">
        <property type="nucleotide sequence ID" value="XM_062871383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GX81"/>
    <dbReference type="GeneID" id="87890212"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015969">
        <property type="term" value="P:guanosine tetraphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05399">
        <property type="entry name" value="NT_Rel-Spo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007685">
        <property type="entry name" value="RelA_SpoT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41773">
        <property type="entry name" value="GTP PYROPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41773:SF1">
        <property type="entry name" value="RELA_SPOT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04607">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RelA/SpoT" evidence="2">
        <location>
            <begin position="100"/>
            <end position="265"/>
        </location>
    </feature>
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        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3307767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="502" mass="58000" checksum="C124EE8688A9C36C" modified="2024-07-24" version="1">MADEEDAQFEELLHEFALEYRRRTRSLEAHMDAAKRKLESEMGGLREAMNVRHMPVSSRLKDEAKALRTLRRRQEDRKQLRSLREMVEARGFETWEQYCREWGMADKVHESEPFESVEQMFAAMHDLAGIRVSIYFPTDVQKVVDFLREHFRIVEGPSQKGGLARDLQKVRRLVERQRQIDSAAAEEEAPGAQEAQAGPVPGPGLDLTFSGYRATHVVICHKSLDFDQHARGEDVVNIEVQIGSIIMHAWSDIEHDILYKPSATGEPSADVVRMLDLINGIVMTGEVALQQLASVAAAETARQAEDRRKTAVDWPYMLPWFDKYFADRNIFVPPRKNQWMTPQYLFQVLRATDEHTYGRVEELLDSMGAKPEEHLSVLLLQHIGRDTFPFQDLPSSGLPLQYATTWNARYWATCLVNTFNLASFMNSFPSMYWTITQRWNDEENKQVYPYRPTFAEFLDILHPTKPQRKIDREPWMILFCKRILSTTCKALVSSYSSALSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GXD3</accession>
    <name>A0AAJ0GXD3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_87702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3307884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723664.1">
        <property type="nucleotide sequence ID" value="XM_062871413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GXD3"/>
    <dbReference type="GeneID" id="87890242"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="673"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="857"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1024"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="680"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="806"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="827"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="879"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
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        <source>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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                <person name="Kuo A."/>
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                <person name="Riley R."/>
                <person name="LaButti K."/>
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                <person name="Ament-Velasquez S.L."/>
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                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Haridas S."/>
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                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
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                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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        </source>
    </evidence>
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                <person name="Cros-Aarteil S."/>
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                <person name="Kuo A."/>
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                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
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                <person name="Ament-Velasquez S.L."/>
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                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
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                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Bonometti L."/>
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                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
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                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
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                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
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                <person name="Hutchinson M.I."/>
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                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
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    </reference>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">Thioesterase-like superfamily-domain-containing protein</fullName>
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    <organism evidence="2 3">
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
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                <person name="Riley R."/>
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                <person name="Andreopoulos B."/>
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                <person name="Ng V."/>
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                <person name="Ament-Velasquez S.L."/>
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                <person name="Powell A.J."/>
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                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
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                <person name="Hiltunen Thoren M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724068.1">
        <property type="nucleotide sequence ID" value="XM_062870894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GY36"/>
    <dbReference type="GeneID" id="87889723"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00586">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050563">
        <property type="entry name" value="4-hydroxybenzoyl-CoA_TE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31793">
        <property type="entry name" value="4-HYDROXYBENZOYL-COA THIOESTERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31793:SF39">
        <property type="entry name" value="THIOESTERASE_THIOL ESTER DEHYDRASE-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13279">
        <property type="entry name" value="4HBT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3308288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="327" mass="36965" checksum="3DD8C1A0790C4E3F" modified="2024-07-24" version="1">MPSLLPPAQVRLAGRVFQCRRVSRGSPPSVSPSPRLYPHRPFSVSSARPSATPTTTTSDNSAAKPPPLPPSRWITELRTRVGKCLLFGCNSQQISQAAGVMRALATEWRELLAGSEGFLTGGRRGLDGREIVWGEMDTFGHVNNVNYYRYAESARVNWITNFAVHVDPAHREQWRELMSPRATGLIMRSLKADFKFPMVYPDKISVYHKLRAKPEGDPAPSSFFLDCIVLSHQHRRVSCRLEEDIVIYDYKAGGKTSMPSFMVELFDQTWKLQEQETLRARTRIWDLIRAVERLEKETWTRTKLTLSVGDRPDAVEDMGGSKDSSNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GYB2</accession>
    <name>A0AAJ0GYB2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GNAT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_490726</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyltransferase family. GNAT subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723910.1">
        <property type="nucleotide sequence ID" value="XM_062866706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GYB2"/>
    <dbReference type="GeneID" id="87885535"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039135">
        <property type="entry name" value="NAT9-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13256:SF16">
        <property type="entry name" value="ALPHA_BETA-TUBULIN-N-ACETYLTRANSFERASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13256">
        <property type="entry name" value="N-ACETYLTRANSFERASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="34"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3308130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="242" mass="27034" checksum="530D0D506B1CADBE" modified="2024-07-24" version="1">MRLNEFSAVSTTKALLVPYDAHHVLTYHGWMEDPVIQAATASERLTLEEEYENQQSWRASHDKLTFIICQPLSTGEADGASIHAGGPDAPAKMVGDVNLFLYPYEEDEDGEQPPSETPGFCVGEIDIMIADQKHRGKGFGRAAVQAFVQYIFRHLDAVMREYAEDKDMASPPELKMLMAKINQGNATSIALFESLGFEQEGEVNYFGEVKLVLRRIDGFAANVPEGYAEMVYSRIQNHDKPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GYB3</accession>
    <name>A0AAJ0GYB3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_483092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724201.1">
        <property type="nucleotide sequence ID" value="XM_062866143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GYB3"/>
    <dbReference type="GeneID" id="87884972"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042460888" description="Protein kinase domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3308421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="217" mass="24457" checksum="17700B2D8C9F8743" modified="2024-07-24" version="1">MAPSLQILFHLLLADNFISRGVAGHIFQESGKKIKAKKAEYRVLIKHPYLNIVQYILYVPEGIFLYRIESTAIAWLERLGLVHGDLRPANTLLNIKDNIQLSDFDATVKPGAELIVTYEPLYKIDENFKPPLAGPVSEQFSLASYIYNIPRVKKLIRDEFPSVSVDLVFSDQDVLPRLGRSAAEDIALMQASIKEVAAQYPLPRAECEEFVAKQAWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GYI0</accession>
    <name>A0AAJ0GYI0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_524471</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724234.1">
        <property type="nucleotide sequence ID" value="XM_062868765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GYI0"/>
    <dbReference type="GeneID" id="87887594"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="41"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3308454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="769" mass="85036" checksum="1FA8206F796E5970" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GZL5</accession>
    <name>A0AAJ0GZL5_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <lineage>
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            <taxon>Ascomycota</taxon>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724460.1">
        <property type="nucleotide sequence ID" value="XM_062861545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GZL5"/>
    <dbReference type="GeneID" id="87880374"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3308680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="321" mass="35728" checksum="D0B8459104AA9F71" modified="2024-07-24" version="1">MTFGDGVKALLDTYANCISLLKTFRRNRDEAPGASVGAQQRHSHLRKCLRSDRSLVERAYSSRVSESGKRFKKGDARAKTAVDRILKRLRNAIANLLRLSSRRDGLDLDYESLMSLSNASRVEAIKAIDSLSRRLGGPSRSSIASSLSESSSKRSSATRHKHKRGSSSNTRSSASRQDNATEQHDLQSQKPRTTAKEGKATSRQCKADDAERLRKGPPPLSVAPPKVRNAQPQTPIPRTTSPGVKAPKSAWANRISILSFSSGSTKLGEIPQRKWQSTMQYTATDVDGDEYNVRPMFPLKPYTVEVKERRFWGLFSRRREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H0F1</accession>
    <name>A0AAJ0H0F1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP-NAD kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_5586</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725318.1">
        <property type="nucleotide sequence ID" value="XM_062870474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H0F1"/>
    <dbReference type="GeneID" id="87889303"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.30:FF:000005">
        <property type="entry name" value="NAD+ kinase Utr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10330:FF:000025">
        <property type="entry name" value="NAD+ kinase Utr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF0">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="63"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="604"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="621"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3309538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="658" mass="71516" checksum="E07E7063B75E37A4" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H0R2</accession>
    <name>A0AAJ0H0R2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Isochorismatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_2292</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725184.1">
        <property type="nucleotide sequence ID" value="XM_062862924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H0R2"/>
    <dbReference type="GeneID" id="87881753"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053152">
        <property type="entry name" value="Hydrolase_YcaC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43559">
        <property type="entry name" value="HYDROLASE YCAC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43559:SF3">
        <property type="entry name" value="HYDROLASE YCAC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042595170" evidence="2">
        <location>
            <begin position="20"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="32"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3309404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="240" mass="25906" checksum="96D3A4DB8044007F" modified="2024-07-24" version="1">MKFAAGILSATFVAGTVTADSFAYERLSKNESMLVIVDHQEGLFSLARDWDATLFKDAMFAHAAIGKAFGLPVVMTTSAEKGPNGPLPQEILDMYPDAPLIARPGEVNAWDNADFRAAVKAANKTQIILAGIVTDVCTAFLARSLRAEGYSVWANFEASGTTTKEIREIANAQLLRAGVNVVSLFAIVGDLMRDWRSVPGAKEMFPWLDRYFPAAGMVARAHRAAIENGVVMPGQGDLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H1E4</accession>
    <name>A0AAJ0H1E4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_22627</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725841.1">
        <property type="nucleotide sequence ID" value="XM_062862884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H1E4"/>
    <dbReference type="GeneID" id="87881713"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053203">
        <property type="entry name" value="Cisplatin_resist-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022024">
        <property type="entry name" value="DUF3602"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693">
        <property type="entry name" value="PROTEIN PAR32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693:SF1">
        <property type="entry name" value="PROTEIN PAR32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12223">
        <property type="entry name" value="DUF3602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3310061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="169" mass="17790" checksum="6537B032F14E1B7D" modified="2024-07-24" version="1">MSTQLQSSGRGGAGNIVDSSKSPPLQPEDLQTPTLKTSKVTTGRGGTGNFASNLDPEEKRRRQDVEPVVRRMSHGATHIGRGGTGNVVKTGPSDDKVPSPAGSPALSPVPAAGLDKVPSRTDKEHKEKEKEKRSSPTGSDTASDVAVPARKTEEIGWAEKGRNLLFGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H1E5</accession>
    <name>A0AAJ0H1E5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Diphthamide biosynthesis protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_564162</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DPH4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062870636.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87889465"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.660.10">
        <property type="entry name" value="DPH Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007872">
        <property type="entry name" value="DPH_MB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036671">
        <property type="entry name" value="DPH_MB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037507">
        <property type="entry name" value="Ribosomal_mL59"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040922">
        <property type="entry name" value="Ribosomal_mL59_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28041">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28041:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18126">
        <property type="entry name" value="Mitoc_mL59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05207">
        <property type="entry name" value="Zn_ribbon_CSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CSL zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DPH_MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="193"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="DPH-type MB" evidence="8">
        <location>
            <begin position="302"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="155"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="288"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3310013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="373" mass="41372" checksum="3E20D1888F4CE5EF" modified="2024-07-24" version="1">MATAVSKNVQLALALPARLRTFLARYPPASILPAGVDPETHKTAYQEETPNPFLPTKHPVTGRWHDPKYSMRRQAELVKMAREHGVEELLPYTPKGTEVRLRKRVELGLRVRGTGVGQQVKGHKHERQLGVKYDGEEKTGYVGDAGAHQRMEEDYSGGTDYHHQTQHQLNSPTRGVPTPLKPSTTMPPALVPNYYEVLNLSQATLSTHDEATAAALVKRAYRRALLNHHPDKTKHQHQHQNQQQGNTTVPTSFTVDQISSAYATLSRPGQRKAYDRTLQLQRQAQQQGPSTAGGTPSDFQTGIENVDLDDLASDGEADGTTGWYRACRCGNPRGYHFTEADLEDAADLGELMVGCTDCSLWLRVHFAVVDDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H1H5</accession>
    <name>A0AAJ0H1H5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PhoD-like phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_481564</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725854.1">
        <property type="nucleotide sequence ID" value="XM_062866034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H1H5"/>
    <dbReference type="GeneID" id="87884863"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043904">
        <property type="entry name" value="PhoD_2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689:SF2">
        <property type="entry name" value="WW DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G06520)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19050">
        <property type="entry name" value="PhoD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoD-like phosphatase" evidence="2">
        <location>
            <begin position="664"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="229"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="296"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="402"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3310074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1219" mass="130508" checksum="A1CE66BD5074F7BE" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H1K1</accession>
    <name>A0AAJ0H1K1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome biogenesis protein ERB1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Eukaryotic ribosome biogenesis protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ERB1</name>
        <name evidence="10" type="ORF">B0T15DRAFT_26008</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat BOP1/ERB1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H1K1"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000061">
        <property type="entry name" value="Ribosome biogenesis protein BOP1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03027">
        <property type="entry name" value="BOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028598">
        <property type="entry name" value="BOP1/Erb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012953">
        <property type="entry name" value="BOP1_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605:SF0">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1 BLOCK OF PROLIFERATION 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08145">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01035">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BOP1 N-terminal" evidence="9">
        <location>
            <begin position="163"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="432"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="758"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="35"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="105"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3310138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="783" mass="88002" checksum="E06EF294809F579F" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H1S9</accession>
    <name>A0AAJ0H1S9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_488640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725720.1">
        <property type="nucleotide sequence ID" value="XM_062866529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H1S9"/>
    <dbReference type="GeneID" id="87885358"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3309940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="187" mass="20947" checksum="1B8B81A57683A5F9" modified="2024-07-24" version="1">MPTETTFLACLKVTTLFLFGFFDMIMTPAYIAAGEPLVKTAGVALCGVIPAVYVAWSTSPFVAAIHMHLPPYARWSRAILERFARTAPPNTRLDVTTMSLIGKPRVSSMVLSDLRPARRRFGIVNYVRDTSLLEAKRRWWRFKAVGEFNVQEDGDKKVKNGWVWREVKEGIARRGSAAGQVQGEKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H1Z4</accession>
    <name>A0AAJ0H1Z4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Oxysterol binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_481730</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726109.1">
        <property type="nucleotide sequence ID" value="XM_062866047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H1Z4"/>
    <dbReference type="GeneID" id="87884876"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008142">
        <property type="term" value="F:oxysterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120009">
        <property type="term" value="P:intermembrane lipid transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2720:FF:000003">
        <property type="entry name" value="Oxysterol binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000010">
        <property type="entry name" value="Oxysterol-binding protein homolog 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF184">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN HOMOLOG 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="406"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3310329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="417" mass="45458" checksum="E9474B0A1DE9E3C2" modified="2024-07-24" version="1">MDSTTAPQPAGGMGASWGAFLKSIASFNGDLSSLTAPPFILSSTSLTEFSSYWCEHPSVFAAPAKETDAAKRALLVLKWFLTTLKQQYASRSEQYGNEKKPLNPFLGELFLGKWEDNAGTTELISEQVSHHPPATAYNITNIPSGVRLEGYNAQKASFSKTINIKQIGHAVLTVPVPSSEEHDTFLITLPALHIEGLIFGSPFIELEGSSYITSSTGFTAKIDYSGKGWLSGKKNSFTAVLYATGKEKDVLFNVSGQWTKTFEIHSGPTKHNSKDNLLETWDPAESPASQLIVAPLEKQHPLESRRAWAKVADAIAQGDLDRVSQEKGKIENAQREMRVKERAEGRTWQRRYFTARNDSADPVLTSLGPAVSLAQDGDADKTGGLWRFDAAKAEAAHNEPALSDEDAGKLARELLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H329</accession>
    <name>A0AAJ0H329_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arb2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_426695</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726722.1">
        <property type="nucleotide sequence ID" value="XM_062865655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H329"/>
    <dbReference type="GeneID" id="87884484"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035197">
        <property type="term" value="F:siRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048263">
        <property type="entry name" value="Arb2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053858">
        <property type="entry name" value="Arb2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21357">
        <property type="entry name" value="FAM172 FAMILY PROTEIN HOMOLOG CG10038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21357:SF4">
        <property type="entry name" value="FAM172 FAMILY PROTEIN HOMOLOG CG10038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22749">
        <property type="entry name" value="Arb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arb2" evidence="2">
        <location>
            <begin position="15"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3310942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="483" mass="52709" checksum="7E8A90D60A2B3025" modified="2024-07-24" version="1">MFRRRWSGLPADPVFPSDLKELGYFINDMDEIRSVEYSDYYFKYFLTKNTRWNERQRFAFNDAVTKIIRTRLTTTEHLTTVPLPLGTPPSQPHVPIMVSANLSAATRVVLLVGEPCQSLGVLAHRVIGGRGGITRGSALGLIQGLKTQQSSASDRAPPGVVLANPGELWWWPEGGRGLTPIERHQVPMSSAVHYGRRHDPKVNEVPENRSVAEHVRGVFEAVVMGDMLRKEAKVDVIAVGDAADVVEAYLNDDKVWEKVKGRLGCLVVMGGFYNSDNFKCEGFKEFMKERARAYIIHHTPLDTPISGASGNPGAAAFTAYGCPVYSAGDTKVTETMLIDAQPAVLKWIQRVALEGDAYKNEELEFFGEEGTGITTEALDSPWMDVAEENGTQPNAKEGVTLTDSAAERDSGEAQAQENESAKTGDTKARADVKEVQTDEEAMGGGEKVEGGESESKPSPTREAHGPGDLADLAKRTDDVQITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H3E9</accession>
    <name>A0AAJ0H3E9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_548299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726873.1">
        <property type="nucleotide sequence ID" value="XM_062870194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H3E9"/>
    <dbReference type="GeneID" id="87889023"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3311093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="301" mass="34331" checksum="63D48B5FB4B863B9" modified="2024-07-24" version="1">MPRRKRSRKPPPFPALPPEKLQPPGGGPERFESEFTHEELLWLYRTKLEQNHRYQCCWLQIERSYGPSMDKVEPHLGQMGQYGLDDRWYQSVPMYFLGTLRHRWYVVRILIEKYIYKRWFRPYRSAIELGQYLMFISPKGVSSPDSPPSRSVVEYLLAMNKAVCANAEKYAQEALRSELGSGEQIAESTPSRSTRMLNPLVKVIIMIVYPDTIGSLPVYLVRTGVEEGLSAPISFDSISDKVEPQEAEGVVKTNLETAIDFVMALDAREEASFGPQPDLLGIAARHYRDEGADKLTTLPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H3R5</accession>
    <name>A0AAJ0H3R5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_388399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727026.1">
        <property type="nucleotide sequence ID" value="XM_062864445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H3R5"/>
    <dbReference type="GeneID" id="87883274"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF48">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="16"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3311246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="203" mass="23378" checksum="179EB73BCDC99D54" modified="2024-07-24" version="1" fragment="single">RTYHFMSRAAGVTLESLWPELSTEHKISIKTQLNSIFRALRKEHGGRPKFGGFVSAICKDTRRNQRVSEPTIHTEAQFNDFLCGKPGRAPTAWITTIRSGMRDDHRLVMTHGDLHPRNIMVQWERGAEDGVTGKGGEKKIRVTALIDWEMSGWYPEYWEFVKSLSTINTRGTLSDWFEYLPTDAIRTWPVELSIDSLLERWLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H436</accession>
    <name>A0AAJ0H436_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mating-type protein MAT alpha 1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_482472</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MATALPHA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727238.1">
        <property type="nucleotide sequence ID" value="XM_062866104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H436"/>
    <dbReference type="GeneID" id="87884933"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008301">
        <property type="term" value="F:DNA binding, bending"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045895">
        <property type="term" value="P:positive regulation of mating-type specific transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006856">
        <property type="entry name" value="MATalpha_HMGbox"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04769">
        <property type="entry name" value="MATalpha_HMGbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51325">
        <property type="entry name" value="ALPHA_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Alpha box" evidence="6">
        <location>
            <begin position="26"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3311458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="272" mass="30870" checksum="5BDB39446564DBC3" modified="2024-07-24" version="1">MYHKKATEIKAKRIMPRMMGAVPQQPVKKKVNGFMGYRAYYSSLFSQLTQKEKSPIMTALWKRDPFHKEWDFMCLVYSAIREFLSNENVSLQTWIESAIGHMGIVVRDNYMRTFGWSVVRLQDGTHKVVRNHPRTVQSFLQPMNGLGIFMKCLNNGLPIADPVPIISKLSGLTNDVICINTHPGAAPQFTNTMEEFRQFARTHPQLAMSALWQVPVTHPLITQGVSVHNVEDLPAPGAELDDAELDAMIDEIFMDTYGPNHPYFTSRQANSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H474</accession>
    <name>A0AAJ0H474_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome c oxidase subunit 13, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Cytochrome c oxidase polypeptide VIa</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0T15DRAFT_521500</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the cytochrome c oxidase subunit 6A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727231.1">
        <property type="nucleotide sequence ID" value="XM_062868566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H474"/>
    <dbReference type="GeneID" id="87887395"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.95.10:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit 6A, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.95.10">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001349">
        <property type="entry name" value="Cyt_c_oxidase_su6a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036418">
        <property type="entry name" value="Cyt_c_oxidase_su6a_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11504">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE VIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11504:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02046">
        <property type="entry name" value="COX6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000277">
        <property type="entry name" value="COX6A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81411">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3311451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="128" mass="15515" checksum="B572CBB6633CBD2B" modified="2024-07-24" version="1">MFPQRIVRAAPRFTAQLRAQAQRRFASTETENAFIRERRHVKEHAHATTELWRKISIYAVPPALILAMLNAYNLWNEHWEHWSHMPPLEERVEYPYQNLRTRNYPWGNGDKTLFWNDQVNYHNKDKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H497</accession>
    <name>A0AAJ0H497_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CBM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_482545</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727328.1">
        <property type="nucleotide sequence ID" value="XM_062866112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H497"/>
    <dbReference type="GeneID" id="87884941"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042581680" description="CBM1 domain-containing protein" evidence="5">
        <location>
            <begin position="17"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="6">
        <location>
            <begin position="305"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="274"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3311548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="341" mass="34813" checksum="7C09770B96A8940E" modified="2024-07-24" version="1">MKALLPALILVGLSSASPVLDNEARQNGGVGNGPFAPAGYYTTNALGGHTFFAPTSAPPNVKLPVLVWGNGACSADSLGQAPFLTQLASYGVLVIASGTPRGGGSTTADTMKQSIDFITRNAGQGQFANVDASRITAAGFSCGGVEAYAQINDARVQHVGIWSSGLLSDYDAARSFRKPVFFFLGGLSDIAYQNGERDYSYMPSGVPKWKGNLDVGHGGTYGDYNGGKFGVIGGYWVQWMMRGNSSAAAYLTGSGARNDGWSVVHADLDRLSVTPIGDGSGGGGGSSTTTSAGAEPTGGGNGGGSCSVLYGQCGGQGWNGPTCCSQGTCKSSNPWYSQCLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H4L1</accession>
    <name>A0AAJ0H4L1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_521439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727205.1">
        <property type="nucleotide sequence ID" value="XM_062868559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H4L1"/>
    <dbReference type="GeneID" id="87887388"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="158"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3311425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="238" mass="23034" checksum="74D6A1B65A634BD5" modified="2024-07-24" version="1">MTAPLPAGSTSCNETGIASATGPGPAQPPTTTCHETPSSSSSVVPIESATSASVSASASSSTSTSCSETWLTFTIPATTTVAVTLSAPASGSGSSSFSLSTSTCTETTLRTVTVLSSATGGSSGGSGSGGPAPLSPSSSSGFFTTGTVTPFFPPSPSPSSVSVSVSSETLSPLAPPQQPPTSLAPPPPPNNPLDPGEGTLDHRHTITISGPPPPARGHHQEPTGTTAAAAATEIFVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H517</accession>
    <name>A0AAJ0H517_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ABC-2 type transporter-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0T15DRAFT_386743</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727460.1">
        <property type="nucleotide sequence ID" value="XM_062864339.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87883168"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="603"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="653"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="685"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="715"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="822"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1247"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1280"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1319"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1359"/>
            <end position="1378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1390"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1515"/>
            <end position="1533"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="216"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="910"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="866"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="127"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3311680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1579" mass="174351" checksum="036EEF5298956EC5" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LXU0</accession>
    <name>A0AAJ0LXU0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_320992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717461.1">
        <property type="nucleotide sequence ID" value="XM_062864053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LXU0"/>
    <dbReference type="GeneID" id="87882882"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05289">
        <property type="entry name" value="MDR_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050700">
        <property type="entry name" value="YIM1/Zinc_Alcohol_DH_Fams"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695:SF647">
        <property type="entry name" value="ENOYL REDUCTASE (ER) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="19"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3301681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="343" mass="35842" checksum="0517CBD7B287AE08" modified="2024-07-24" version="1">MAAQELPKTMKTLLQASRKTTEVISTTAPVPTPTHPDDVLVRVHATAPCAGELLWAINFPDSIPADKEMVPCQDMAGRVVSAPANSGFAAGDRVYCRISAERAGAARDYALPRASELAKIPEGLGWIEAAATPLSALTAWQALFVQGTLDAASVKGNAAAREKNGKVRVLVTGAAGGVGSWAVQLAALAGAKAVVAVCGPGKEEAARKLGATEVVNYAETSIEDWVAADPAARECDLIVEMVGGKTLEGCWAAVREGGAMITINTPPEYGKPAGLKKELSKALFFIVEPLGSNLAEIGDLIVAGKVRPTVDSVWEFADYKKAFKRLESGHANGKIIIKVSDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LXV1</accession>
    <name>A0AAJ0LXV1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_544488</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717522.1">
        <property type="nucleotide sequence ID" value="XM_062870084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LXV1"/>
    <dbReference type="GeneID" id="87888913"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051052">
        <property type="entry name" value="Diverse_substrate_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942">
        <property type="entry name" value="METHYLTRANSF_11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942:SF10">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="2">
        <location>
            <begin position="71"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3301742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="368" mass="39721" checksum="4A64465088CECAED" modified="2024-07-24" version="1">MTNKTTQPPIQTQGPTTPPTTTAAAKETTFRSFSRAQGASYAQHRLDYHPRLYQLVLDHHNATGGRLDTLLDVGCGPGTAVRTLAPHFAHALGIDPSEGMIATARSLGGYCCSGSGSTPEKKEPIRFEVSTVEELEMGISRDGTGIQEGSVDLLVAATAAHWFDMSVFWPLAARLLRPGGTVALWTGGRILVDADQRCGSVPNNNAKAIQVALDRFDAAVDEYFLPGNRMVSNLYADLQLPWMLERPVAEFERDGFVRKLWDNGTTSSGGGTEDGEKGEGYIKEFYTGDQKGADVEVLVKILATTSPYIRWREANADAVDTDKDPLQVMRREIELALEQGGVGGGKRLVKGGVAGVLLMVKKRAQAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LY09</accession>
    <name>A0AAJ0LY09_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_563572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717671.1">
        <property type="nucleotide sequence ID" value="XM_062870625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LY09"/>
    <dbReference type="GeneID" id="87889454"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF35">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE FAMILY PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3301891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="300" mass="32956" checksum="66CEABE7A7922868" modified="2024-07-24" version="1">MPSFARECKQRLSRVPPIPARTELAGKTVLVTGANVDLGFEASPNFLRLRPSLLIMGVRSVDKGEAAAAALRREFPDARIEVWELDMESSRSLDRLHVAVLNAGLGKPRFERVDEGGCHEVTIHLRPTASSSEPGRLFIVNSGASLGLTLEDPGDARLLDSFDQPGKFNGIGQYGLSKLLVMMFVAKPARTINPKEVIVNCTDPGATKGTAFFCDVNSWIISVALRAFVGLIGRQAADASRVYLHSSLVLGEESHESWTGWIIRAWPKTMYTDQGHQLGEWLWDETLEELKFASVKALAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LY82</accession>
    <name>A0AAJ0LY82_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_541662</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3301998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717778.1">
        <property type="nucleotide sequence ID" value="XM_062869877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LY82"/>
    <dbReference type="GeneID" id="87888706"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Clavaminate synthase-like"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3301998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="279" mass="31644" checksum="DAB8106196A1E968" modified="2024-07-24" version="1">MDPNDRSTWTRLRTNMPHHTTWDASQFAPRAWAAICELCGGEDRVDPDSKTWRDSLIVNLGAPEYESKPVPPQDLPEWHVDGDFFVHYLDSPEQALLVTPLFTDIVPNGGATYICPEAIPKVAKHLYEHPEGVSPRMTPRADPGFRQEKDLSWFCNVAKSCDNFIEATGQVGDVYLMHPLMLHAPSSNSLRRVRIITNPPVSLREPHCFDREDENYSLVEQVTLRALGKDRLSGWKIAGPRERVVPERVKAQERMRLEELRRLEELKAMEGQPAVSAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ0LZ72_9PEZI</name>
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        <recommendedName>
            <fullName evidence="2">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_263297</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718874.1">
        <property type="nucleotide sequence ID" value="XM_062863367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZ72"/>
    <dbReference type="GeneID" id="87882196"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47800">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47800:SF5">
        <property type="entry name" value="FER-1-LIKE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="18"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="587"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
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            <begin position="443"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3303094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="609" mass="68693" checksum="EDD49DCB01F178DC" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
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    <protein>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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    <organism evidence="1 2">
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718860.1">
        <property type="nucleotide sequence ID" value="XM_062863362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZ75"/>
    <dbReference type="GeneID" id="87882191"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3303080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="144" mass="14787" checksum="1BA691218817EBCA" modified="2024-07-24" version="1">MSSATPIPVASLGANPDVAKEIQNLLLPEYDVVHMCMDGKSAITELPPLCGGNTATAPSSGLGSNVDREAAERKVPKVVIFGGAVTDDEAKSVSEAVAVLAPQVKMVRVTKDDISAAGSAGPNPEVIVKVLREKLGKLIQGGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZ94</accession>
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        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_513374</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718949.1">
        <property type="nucleotide sequence ID" value="XM_062868034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZ94"/>
    <dbReference type="GeneID" id="87886863"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000003">
        <property type="entry name" value="60S ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00499">
        <property type="entry name" value="Ribosomal_eL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001380">
        <property type="entry name" value="Ribosomal_eL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018256">
        <property type="entry name" value="Ribosomal_eL13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11722:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01294">
        <property type="entry name" value="Ribosomal_L13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01104">
        <property type="entry name" value="RIBOSOMAL_L13E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3303169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="213" mass="24168" checksum="E41B52D758DE934C" modified="2024-07-24" version="1">MAIKHNQQIPNNHFRKQWQRRVRCHFDQPGKKVTRRLARRAKAAAVAPRPVDKLRPVVRCPTIKYNRRTRLGRGFTLAELKAAGIPKLYAPTVGIAVDHRRQNLSEESLAINVQRLKEYKARLIVFPRKSNKPKKTDTPKDQQTAETTQRIAASFGVENPIASAFSEISKSDMPKGVEGGAYKALRKARSDARLVGVREKRAKEKADEEKAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZM3</accession>
    <name>A0AAJ0LZM3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Exocyst complex component Sec3-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_420918</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719366.1">
        <property type="nucleotide sequence ID" value="XM_062865548.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87884377"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13315">
        <property type="entry name" value="PH_Sec3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.90:FF:000003">
        <property type="entry name" value="Exocyst complex component Sec3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028258">
        <property type="entry name" value="Sec3-PIP2_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048628">
        <property type="entry name" value="Sec3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019160">
        <property type="entry name" value="Sec3_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092:SF14">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 1 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092">
        <property type="entry name" value="SEC3/SYNTAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15277">
        <property type="entry name" value="Sec3-PIP2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20654">
        <property type="entry name" value="Sec3_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09763">
        <property type="entry name" value="Sec3_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01313">
        <property type="entry name" value="Sec3-PIP2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec3 PIP2-binding N-terminal" evidence="6">
        <location>
            <begin position="64"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="185"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="468"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1320"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="260"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="400"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="500"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="557"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1328"/>
            <end position="1344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3303586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1408" mass="155016" checksum="41BF49012CEC2D9B" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZV5</accession>
    <name>A0AAJ0LZV5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_487113</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719579.1">
        <property type="nucleotide sequence ID" value="XM_062866412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZV5"/>
    <dbReference type="GeneID" id="87885241"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3303799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="462" mass="51712" checksum="61E03EA9A1CAF808" modified="2024-07-24" version="1">MTDITALILSPRFLISAALLVAGNAVFFLLLSYTHRPRGFPPGPLGLPGFGSLFQINKSIPALTYSAWAHKYGQDRPLGVKLGATNIVVLNSARMVRDLFERRGAIYSDRPRPNGEDEKWKFQTHHVPASLFHDSGPWLTRWRREFNGGLGSAAAVARLHPMNDAETARALVALLEAGPTTRRAELEDIILSWVTSVPCIAVVGRRPDAMAHHGFDMDAFRRRTAGYMMLHKPNLMDRIPVLRYLPGKFGMAGWRAKSHAVAKDYPDVQQRIRDESADVARLTYTEAFWHEGIPHAPAQDDVYDGYRIPKHTAVYANVWHIHHSPEDYESPEKFEPERFLRHPFGMRPGAAHDPAAMEGSASASARATYAFGFGRRVCPGMLLAKQSLILGLAKVLWAFDVLPAQEGQELDLNVDTGFVQGLITFHPKHLDVSLRLRPGRSKQDILDHYSETYKVEAEVMGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M0T9</accession>
    <name>A0AAJ0M0T9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CENP-S associating centromere protein X-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_251303</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CENP-X/MHF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720493.1">
        <property type="nucleotide sequence ID" value="XM_062863185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M0T9"/>
    <dbReference type="GeneID" id="87882014"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071821">
        <property type="term" value="C:FANCM-MHF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22921">
        <property type="entry name" value="HFD_CENP-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018552">
        <property type="entry name" value="CENP-X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28680">
        <property type="entry name" value="CENTROMERE PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28680:SF1">
        <property type="entry name" value="CENTROMERE PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09415">
        <property type="entry name" value="CENP-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3304713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="169" mass="18440" checksum="19D5587E3E1D6166" modified="2024-07-24" version="1">MPPKQSTSGPATRGGRGRPSGSRGGAAAASSKNKTTSTSTASASATARAKGAVSQRREARREVEDGDEMEIDVDARAEREVQVQEIGDDDEEEGEDDRERIPPELLTRILYEFFEREGTRITKDANSAVARYVDVFVREAIARAAVEREGGFLEVEDLEKIAPQLLMDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M0U8</accession>
    <name>A0AAJ0M0U8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_486331</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720626.1">
        <property type="nucleotide sequence ID" value="XM_062866347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M0U8"/>
    <dbReference type="GeneID" id="87885176"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3304846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="337" mass="39243" checksum="1B02BA2A9F0D0E3F" modified="2024-07-24" version="1">MELWSEPLPNTSYNAVLSDSIASPLNSRMLYNRQSEKNNFWPKRVISIGNPNKLILVEGQLYREDYLVLSYCWGPLIDQEKKRFYTTSENYEARKRGFNYDELPKTFQDAVQGPDGDWDSEATTIADIFACAYYTIAASSPLFILTYIYDFEKDVDKGPLIKRAWLIKLEPPFGKQYFILDPNFPHRLQQSRFTCTVDFVQFLFRKYSISGLTVKTNRDIAIYSLVEHIGQVLRTKDLLIPRFEDLGFANDGQTLSIEARKFRGNCRMEEKGEEYIIFNGTEKVGSLYMVKDNKEDPRKTYYVLMIREKAGSRGYKRIGVEKVEAQYMSIDCEARML</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M134</accession>
    <name>A0AAJ0M134_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_188618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720881.1">
        <property type="nucleotide sequence ID" value="XM_062862416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M134"/>
    <dbReference type="GeneID" id="87881245"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056021">
        <property type="entry name" value="DUF7600"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24539">
        <property type="entry name" value="DUF7600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="202"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3305101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="705" mass="78496" checksum="F3B477070381CCC6" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M181</accession>
    <name>A0AAJ0M181_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Trafficking protein particle complex subunit BET3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_189626</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Golgi apparatus</location>
            <location evidence="1 8">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720928.1">
        <property type="nucleotide sequence ID" value="XM_062862427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M181"/>
    <dbReference type="GeneID" id="87881256"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14942">
        <property type="entry name" value="TRAPPC3_bet3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1380.20:FF:000001">
        <property type="entry name" value="Trafficking protein particle complex subunit BET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016721">
        <property type="entry name" value="Bet3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13048">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018293">
        <property type="entry name" value="TRAPP_I_complex_Bet3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR018293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3305148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="192" mass="21907" checksum="B9F66C366EA91E69" modified="2024-07-24" version="1">MASSKASRLGEEVWKTRMDKVNAELVVLTYGTIVAQLCKDFDSDYVEVNKQLDKMGYNIGLRLIEDYLAKSNTVRRCSNFRETAEMIAKVGFKIFLNITPAITNWTGDGKQFSLVFDENPFADFVELPDDGRAQDELWYSNILCGVLRGALEMVQMQVEAHFISDVLRGNDTTEMRITLIRYIDDELPPEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M1A1</accession>
    <name>A0AAJ0M1A1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_531637</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720988.1">
        <property type="nucleotide sequence ID" value="XM_062869265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M1A1"/>
    <dbReference type="GeneID" id="87888094"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
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        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF13">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="233"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3305208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="701" mass="78793" checksum="015B370B8DCED1E7" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ0M1A8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Distal membrane-arm assembly complex protein 1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_193509</name>
    </gene>
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        <lineage>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721106.1">
        <property type="nucleotide sequence ID" value="XM_062862476.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87881305"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028036">
        <property type="entry name" value="DMAC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053092">
        <property type="entry name" value="Mitochondrial_unc_protein"/>
    </dbReference>
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        <property type="entry name" value="ACR195WP"/>
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        <property type="entry name" value="ACR195WP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DMAC1_Dmo2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Distal membrane-arm assembly complex protein 1-like" evidence="2">
        <location>
            <begin position="27"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3305326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="94" mass="10200" checksum="FEC31DFBF1CFBAF9" modified="2024-07-24" version="1">MAKDLSLKGLDRPEKLEDLLKEDRGDDCLPCKIVGGGAFLGLAAYSYISGQSQLEQQRAKILASGSRFGMRSRSMGITAISLGLAWLGIWRLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M1D0</accession>
    <name>A0AAJ0M1D0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">B0T15DRAFT_511296</name>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
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                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721154.1">
        <property type="nucleotide sequence ID" value="XM_062867902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M1D0"/>
    <dbReference type="GeneID" id="87886731"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="78"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="125"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3305374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="577" mass="63415" checksum="F6615C89C13E2CF9" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M1F1</accession>
    <name>A0AAJ0M1F1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721241.1">
        <property type="nucleotide sequence ID" value="XM_062865796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M1F1"/>
    <dbReference type="GeneID" id="87884625"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3305461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="235" mass="25721" checksum="57FF27521D3751FC" modified="2024-07-24" version="1">MCLKRKRSESELAVFSSTQSLSSSRFSFDAMSAMDTARRGFFVPRLPTPSHLPIRTMKRFRDNRPSESEVYQHTLDVLYSAQRRDHEPHCVQPPRSPRITGTQAPTEAHTQIRRRGQQRSLHSFWNLPVPATSTDSLTSSPASSAMAPPSPTLTPPGTPTNCEDCGTGLGTGDNDVVMMDIDGYGLGVEDHTCVACGKTVCFSCSVSNLGEHRQCLVCVGPKGRVGGNSWMARHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M1G5</accession>
    <name>A0AAJ0M1G5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquinone biosynthesis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_396877</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Membrane-associated protein that warps the membrane surface to access and bind aromatic isoprenes with high specificity, including ubiquinone (CoQ) isoprene intermediates and presents them directly to Coq7, therefore facilitating the Coq7-mediated hydroxylase step. Participates in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the COQ9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721290.1">
        <property type="nucleotide sequence ID" value="XM_062864863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M1G5"/>
    <dbReference type="GeneID" id="87883692"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.10:FF:000004">
        <property type="entry name" value="Ubiquinone biosynthesis protein COQ9, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.10">
        <property type="entry name" value="Tetracycline Repressor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013718">
        <property type="entry name" value="COQ9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012762">
        <property type="entry name" value="Ubiq_biosynth_COQ9"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02396">
        <property type="entry name" value="diverge_rpsU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21427">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN COQ9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21427:SF19">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN COQ9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08511">
        <property type="entry name" value="COQ9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 8" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="domain" description="COQ9 C-terminal" evidence="9">
        <location>
            <begin position="204"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3305510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="303" mass="32915" checksum="D101F8EE2E140B4D" modified="2024-07-24" version="1">MSSSALACFAGATTARRILLRPRWPTILPGTPSVAAPCRSSSACATRSIIITSQQCDLLPRPRQRQCEQQAIFFTPNRSYHSHDHPPPPGPFTHAEQNLLSAAYVHVPSHGFSQEALALGARDTGLLDISPSILPDGVFSLIRWHLYTQRTLLAAKAKDAVDQTAAVTVGDKVEALAWLRLRGNEAVVGRWQEALAIMAQPSYVPASLKELASLADEILYLAGDVSVDPSWYTKRASLSAIYAAAELFQTTDQSPKFRETRAFLRRRLDEAAQAGGALRSVGEWVGFNASAAVNVLRSKGVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M1X1</accession>
    <name>A0AAJ0M1X1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_533957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721755.1">
        <property type="nucleotide sequence ID" value="XM_062869400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M1X1"/>
    <dbReference type="GeneID" id="87888229"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3305975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="282" mass="29308" checksum="FCB9DB450099D656" modified="2024-07-24" version="1">MNRSRYVPHAVYSINPYASNPYGIGPTQSPMQGGGGMMPPSQAMGMAASQSPYGSPQSQQHHGQSPVQTSLSPNAMWAANFANGPIIEDLCAPPPPPLTMPPAAPPHMRMAAHMHPGAMPQVQNVYGVRQPGGLPLHHHHHPAYAVQGPYPGQPMQGIPTAARVVGTYPPYTSSMPQQPQQVQPGMHLGYHPAGQNATGMLGRPRLETGFPSAPVAAGGPGQQHEGRMGGQMGSPDSGGSMDLGVGTNPVVVSDLEGVAPLTPVEEAIRGFLSPDLGDLGHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M3E4</accession>
    <name>A0AAJ0M3E4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 19">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="4 19">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">B0T15DRAFT_394619</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="19">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="4 19"/>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723390.1">
        <property type="nucleotide sequence ID" value="XM_062864737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M3E4"/>
    <dbReference type="GeneID" id="87883566"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051403">
        <property type="term" value="P:stress-activated MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07856">
        <property type="entry name" value="STKc_Sty1_Hog1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000049">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000050">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008352">
        <property type="entry name" value="MAPK_HOG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038783">
        <property type="entry name" value="MAPK_Sty1/HOG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01773">
        <property type="entry name" value="P38MAPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0010">Activator</keyword>
    <keyword evidence="10 17 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 19 21" id="KW-0418">Kinase</keyword>
    <keyword evidence="19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 17 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7 19" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="20"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAK3307610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="359" mass="41040" checksum="91EDEB9F498E57CE" modified="2024-07-24" version="1">MAEFVRAQIFGTTFEITSRYSDLQPVGMGAFGLVCSAKDQLTNQNVAIKKIMKPFSTPVLAKRTYRELKLLKHLKHENVISLSDIFISPLEDIYFVTELLGTDLHRLLTSRPLEKQFIQYFLYQIMRGLKYVHSAGVVHRDLKPSNILVNENCDLKICDFGLARIQDPQMTGYVSTRYYRAPEIMLTWQKYDVEVDIWSAGCIFAEMLEGKPLFPGKDHVNQFSIITELLGTPPDDVINTIASENTLRFVKSLPRRERQPLKNKFKNADPSAIDMLERMLVFDPKKRITATAALAHDYLAPYHDPTDEPVAEEKFDWSFNDADLPVDTWKIMMYSEILDYHNVGAANVDAMADQGFVGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M403</accession>
    <name>A0AAJ0M403_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mannan endo-1,6-alpha-mannosidase</fullName>
            <ecNumber evidence="4 10">3.2.1.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0T15DRAFT_99215</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Random hydrolysis of (1-&gt;6)-alpha-D-mannosidic linkages in unbranched (1-&gt;6)-mannans.</text>
            <dbReference type="EC" id="3.2.1.101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 76 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.101" evidence="4 10"/>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723928.1">
        <property type="nucleotide sequence ID" value="XM_062871523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M403"/>
    <dbReference type="GeneID" id="87890352"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008496">
        <property type="term" value="F:mannan endo-1,6-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000006">
        <property type="entry name" value="Mannan endo-1,6-alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014480">
        <property type="entry name" value="Mannan-1_6-alpha_mannosidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145:SF41">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016302">
        <property type="entry name" value="Man_a_manosd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 10 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042588594" description="Mannan endo-1,6-alpha-mannosidase" evidence="12">
        <location>
            <begin position="20"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR016302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3308148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="455" mass="49768" checksum="5C3EA0AD82C36764" modified="2024-07-24" version="1">MRFLQLAASLSLLVRSGQAIDLVIGNDDSVKSAASTIAFGLAKYYTGNNTGDTPGNLPDPYFWWEAGAMFGALIDYWALTGDESYNAITKQAIIHQATEKGDFMPRNQTRTLGNDDQGFWGMAAMSAAENKFPNPPDDQPQWLAMAQSLFNQYVSRWDEASCSGGLRWQIFTFNNGYNYKNSISNGCFFNIAARLARYTGNETYATWASKIWNWQEAIGLISDDHHVHDGVHIDLDDNTCKTVDVNEWSYNSGIFLHGAAVMYNFTNGSSTWKTRVDEMLTAATTVFFNDTIMFEQLCEPTGFCNNDQRSFKGYLTRWLAATSQMAPHTFDKIRPLLVADAAAAAKACTGTADPPVFKGHPGTACGFRWTTGGWDGKAGVGEQMNALSAIMYTLVDKVAPPVTADTGGTSKGDVDAKWHEEEVPREITPGDRIAAGFATTAVVFGLVAGCAFVMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M521</accession>
    <name>A0AAJ0M521_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_515212</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725098.1">
        <property type="nucleotide sequence ID" value="XM_062868170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M521"/>
    <dbReference type="GeneID" id="87886999"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033308">
        <property type="entry name" value="PGAP5/Cdc1/Ted1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315">
        <property type="entry name" value="METALLO PHOSPHOESTERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315:SF1">
        <property type="entry name" value="PROTEIN TED1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="528"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3309318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="604" mass="66886" checksum="3DAA8AAE5FAD52B4" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M528</accession>
    <name>A0AAJ0M528_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_996</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725128.1">
        <property type="nucleotide sequence ID" value="XM_062871529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M528"/>
    <dbReference type="GeneID" id="87890358"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3309348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="155" mass="17060" checksum="015107699CB5985A" modified="2024-07-24" version="1">MRLAGKSAPSIDLSLPLLNFQVSASSLPHPPQRNIPPMSVVHLALRCRPQAPLCKRPGPVMQLRRQRICLAATGDDIGFALGQIALHLGSEHLCGDEDACACPCSRTWAVAWAEMVACLAAVLTLLHLRDWTLSRRCFHMASSKNTLHYNRYLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M5H5</accession>
    <name>A0AAJ0M5H5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ELMO/CED-12 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_506312</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725322.1">
        <property type="nucleotide sequence ID" value="XM_062867562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M5H5"/>
    <dbReference type="GeneID" id="87886391"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024574">
        <property type="entry name" value="ELMO_ARM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006816">
        <property type="entry name" value="ELMO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050868">
        <property type="entry name" value="ELMO_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771:SF56">
        <property type="entry name" value="CED-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771">
        <property type="entry name" value="ENGULFMENT AND CELL MOTILITY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11841">
        <property type="entry name" value="ELMO_ARM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04727">
        <property type="entry name" value="ELMO_CED12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16457">
        <property type="entry name" value="PH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51335">
        <property type="entry name" value="ELMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="2" id="KW-0581">Phagocytosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0729">SH3-binding</keyword>
    <feature type="domain" description="ELMO" evidence="6">
        <location>
            <begin position="284"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="613"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="671"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="625"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="671"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3309542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="785" mass="86808" checksum="799140FE3E4DACBA" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M5R4</accession>
    <name>A0AAJ0M5R4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_17255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725670.1">
        <property type="nucleotide sequence ID" value="XM_062862209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M5R4"/>
    <dbReference type="GeneID" id="87881038"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14687">
        <property type="entry name" value="bZIP_ATF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="375"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="295"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="461"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3309890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="493" mass="52847" checksum="6DBA52CDC1787A9B" modified="2024-07-24" version="1">MAYRVASPEFRASNSQLLFQAASVPITRTTLQDEAFGGESMATLYQAMMPMEWRQPLDSREGYPYTPASAQWFQPPSFSGSNTSNDSFVSELPETDAVQWIPSTHAPGVVGEVIMPHELSVQSAVGAGYFLLPPEAGPSSSLFASVPLEHREWARLPDYQRQPTGEYGTGHDRKRRADPHTDADEEVVGPRKKRGRAPAPIQTAEANAALPRYTPIISRASTSDMSHAPTTPSPPNSATVPPFDLADAYYSGSHYQLGGGTATAAPSLGTAFTPGQTAFPESPRRKGFRTRRSSSDAAVSTASTARSTPSHSTTTSSTTTSSTFPTRPVTPIDNHRGSTSTSPSKPAAQAAQSSNSRVSVLGQASRTTTTQSQTRDRNRAAASRYRAKTQAALAQLEATEREVSVRRQSLLTCASQLRDELFRLKNELLRHAGCDCPLIQGYLSHAAEVASAAFRQHHSNETGNGSNGSASGSGRLGRDQPDQVVVARSDLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M654</accession>
    <name>A0AAJ0M654_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ankyrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_481869</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726311.1">
        <property type="nucleotide sequence ID" value="XM_062866058.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87884887"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26128">
        <property type="entry name" value="Gad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="536"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="569"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1443"/>
            <end position="1475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="597"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1161"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1715"/>
            <end position="1818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="601"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="627"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1737"/>
            <end position="1765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1775"/>
            <end position="1787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1809"/>
            <end position="1818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3310531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1818" mass="204840" checksum="3E8A818CF75EB043" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M6J0</accession>
    <name>A0AAJ0M6J0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_56304</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726716.1">
        <property type="nucleotide sequence ID" value="XM_062870602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M6J0"/>
    <dbReference type="GeneID" id="87889431"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF39">
        <property type="entry name" value="TRANSCRIPTION FACTOR PBCR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="22"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="56"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="156"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="169"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="183"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3310936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="758" mass="83330" checksum="EFF30C005C3E9AB3" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M744</accession>
    <name>A0AAJ0M744_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0T15DRAFT_73070</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727169.1">
        <property type="nucleotide sequence ID" value="XM_062871260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M744"/>
    <dbReference type="GeneID" id="87890089"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000067">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF23">
        <property type="entry name" value="FERRIC-CHELATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="219"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="294"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="493"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="15">
        <location>
            <begin position="377"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="635"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="776"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="647"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="788"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3311389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="900" mass="100675" checksum="FFB6689E2E742122" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M768</accession>
    <name>A0AAJ0M768_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0T15DRAFT_521497</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727229.1">
        <property type="nucleotide sequence ID" value="XM_062868565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M768"/>
    <dbReference type="GeneID" id="87887394"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04813">
        <property type="entry name" value="PA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000364">
        <property type="entry name" value="Protease-associated PA domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051653">
        <property type="entry name" value="E3_ligase_sorting_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47168:SF1">
        <property type="entry name" value="OS02G0798600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47168">
        <property type="entry name" value="RING ZINC FINGER DOMAIN SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042468522" description="RING-type E3 ubiquitin transferase" evidence="13">
        <location>
            <begin position="24"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="544"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="666"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="101"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="385"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="427"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="590"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="157"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="441"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="493"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="592"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3311449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="808" mass="87340" checksum="0047D19582E01D17" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M786</accession>
    <name>A0AAJ0M786_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EKC/KEOPS complex subunit BUD32</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Atypical Serine/threonine protein kinase BUD32</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">EKC/KEOPS complex subunit bud32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0T15DRAFT_521399</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727197.1">
        <property type="nucleotide sequence ID" value="XM_062868556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M786"/>
    <dbReference type="GeneID" id="87887385"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27001">
        <property type="entry name" value="OS01G0253100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27001:SF931">
        <property type="entry name" value="OS11G0664100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="1"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3311417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="307" mass="34498" checksum="D0FADEFBB4E72854" modified="2024-07-24" version="1">MTAAMTNITHIVLKSYTPPRVKRLINPSGGSCNIGEIDDTTVLKYPRIKEDMKRVQVEAKMLEVLGPYPRIFMPNGNVHDYLSVHPDVPLHRRLAWCMQAAEAIAYIHSRRVVHCDIRHDNFLLDANLDLKLADFQGQHFSPTGAIVFDGGSYESAKAWLPRHPPDRCNVRTNLFALGSALQFLITGAEVFPDLVRSSETDDDIVRWFHETEPEIERRFRAGEFPPADEHVCAAVTARCWRQLYTIADQVVADLKAIQAAIARGESPETCVSPPNEHDQPCGEKWLYGLCEEGKNLATPPSRTLIGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M7A5</accession>
    <name>A0AAJ0M7A5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_499619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727468.1">
        <property type="nucleotide sequence ID" value="XM_062867344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M7A5"/>
    <dbReference type="GeneID" id="87886173"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3311688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="329" mass="35457" checksum="573AC2D538BDC17E" modified="2024-07-24" version="1">MDGVQKPEVPGPQEIATHPSGWHPQPPNHVGCRDSRPLWTDYWQRFNTITIPLLDEDAFFSDPLAAAKVARNREHLELLEEKSKERGAELEKVLDEIPYAVIYDKNPSSPKPAWDAVRKVGRSGSLDSFIRLASGIEMPHLYSPYPTVSDDWDLLDHGVTEESASPGRPQLPPPSPQPTCGTTARIKDGKTSNGVAQGAPEVSPKSPTASFKTEPVASPAPLSSANDSPTDPALPPSPSDAGPSLTESQATPTTPPPEPPSPREADIQPLLAITSSSPRQDGRQKPVADTCWDSPGGGSKPRGKRRLHELEEPDLEEAACGKRAKREVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M7A7</accession>
    <name>A0AAJ0M7A7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial adapter protein MCP1 transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_490143</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727320.1">
        <property type="nucleotide sequence ID" value="XM_062866656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M7A7"/>
    <dbReference type="GeneID" id="87885485"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039960">
        <property type="entry name" value="MCP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012472">
        <property type="entry name" value="MCP1_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38409">
        <property type="entry name" value="MDM10-COMPLEMENTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38409:SF1">
        <property type="entry name" value="MITOCHONDRIAL ADAPTER PROTEIN MCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07950">
        <property type="entry name" value="MCP1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="321"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Mitochondrial adapter protein MCP1 transmembrane" evidence="3">
        <location>
            <begin position="227"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3311540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="367" mass="39537" checksum="7EEFD056881686FF" modified="2024-07-24" version="1">MDDARSLRSRASQATLISLVELDPAPMEPPNVDKDLPPLPEQQADGALSDSTPSLQASSTSTSLGLGLSGSGHSPIYYLTRIQRYSSYAFTLFGTLHLATTSLIPLAARSVAASESYLLLAREIYQTPLSEPLLVALPILAHVGSGLALRLLRRNQNLRRYYGDHYHDHDHHHPASSSSLDNLKIDNDGAENPVVVFPSRRAAAGGYHGWPPLSGISVSGYIFTGILGAHVAVNRLLPLFSEGDSANIGLAYVAHGFVRHRVASWVAYGVLLGAGCGHMVWGWAKWLGFAQAAGWSWSSLERHTGNVKVDRAVRRMRRRRLLLINGVAVAVMGVWAVGGLGVVARGGETLGWVGRLYDGLLEKVPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GL56</accession>
    <name>A0AAJ0GL56_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_287670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3301958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717738.1">
        <property type="nucleotide sequence ID" value="XM_062863663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GL56"/>
    <dbReference type="GeneID" id="87882492"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042609283" description="Secreted protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3301958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="72" mass="7983" checksum="FF83A3A3732CF90E" modified="2024-07-24" version="1">MLFVMYISGLYPAVCMCAQSLGSPSVSLWTLFTLYPPSRMYVLSARLIASPTLISKPRSRLISQYSCVTDAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GLN2</accession>
    <name>A0AAJ0GLN2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_295768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
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                <person name="Martin F."/>
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                <person name="Lalanne C."/>
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                <person name="Ament-Velasquez S.L."/>
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                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
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                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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        </citation>
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        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
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                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
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                <person name="Barry K."/>
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                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
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                <person name="Johannesson H."/>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Kuo A."/>
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                <person name="LaButti K."/>
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                <person name="Ng V."/>
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        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <person name="Kuo A."/>
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                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
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                <person name="Gladieux P."/>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="3"/>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718060.1">
        <property type="nucleotide sequence ID" value="XM_062869927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GLU3"/>
    <dbReference type="GeneID" id="87888756"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00808">
        <property type="entry name" value="GluRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000045">
        <property type="entry name" value="Glutamate--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00022">
        <property type="entry name" value="Glu_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045462">
        <property type="entry name" value="aa-tRNA-synth_I_cd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020751">
        <property type="entry name" value="aa-tRNA-synth_I_codon-bd_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008925">
        <property type="entry name" value="aa_tRNA-synth_I_cd-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004527">
        <property type="entry name" value="Glu-tRNA-ligase_bac/mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049940">
        <property type="entry name" value="GluQ/Sye"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033910">
        <property type="entry name" value="GluRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00464">
        <property type="entry name" value="gltX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43311">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43311:SF2">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19269">
        <property type="entry name" value="Anticodon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48163">
        <property type="entry name" value="An anticodon-binding domain of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="12">
        <location>
            <begin position="61"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class I anticodon-binding" evidence="13">
        <location>
            <begin position="564"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF19269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3302280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="631" mass="71409" checksum="3ACB0D942DD2DF09" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GM98</accession>
    <name>A0AAJ0GM98_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PrpF protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_403608</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718300.1">
        <property type="nucleotide sequence ID" value="XM_062865214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GM98"/>
    <dbReference type="GeneID" id="87884043"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.10">
        <property type="entry name" value="Diaminopimelate Epimerase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007400">
        <property type="entry name" value="PrpF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43709">
        <property type="entry name" value="ACONITATE ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43709:SF2">
        <property type="entry name" value="DUF453 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G00360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04303">
        <property type="entry name" value="PrpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54506">
        <property type="entry name" value="Diaminopimelate epimerase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3302520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="669" mass="72453" checksum="195963B183688121" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GMW1</accession>
    <name>A0AAJ0GMW1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_495462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3302887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718667.1">
        <property type="nucleotide sequence ID" value="XM_062867100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GMW1"/>
    <dbReference type="GeneID" id="87885929"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3302887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="114" mass="12449" checksum="3E96AB86AC0960A5" modified="2024-07-24" version="1">MVQRALSLRRGNPIPLEIDTVATAASTPAYSTIPVHTAATTATRRDPQLPHSRHHQLRRSSSVSSRVSTASSRDHNRDLYDGGSVVILDDDIDEEKELEGEREGPKGEDTSATM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GNU1</accession>
    <name>A0AAJ0GNU1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_513560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719149.1">
        <property type="nucleotide sequence ID" value="XM_062868047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GNU1"/>
    <dbReference type="GeneID" id="87886876"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3303369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="222" mass="24211" checksum="AE7B81E21E9DEFB2" modified="2024-07-24" version="1">MKEATEGKSTRIYLFRHDRVVQSAHPSRGSVAELMSSPLTNPQARPYVPLNATWFNHPLCLRASNVVPQYPLATYAASEPGVGALGSGSHIADASAFPLAWYETRSSAVLIDEITEHRSSGPGAQKSRLTAILSAYPKLLGIWNSVTLQYPLSGSENPKAVRCQTHKYSLADRAIILRPTSVASELHACGEIEDQKLNEKELVICPMFTEEAAQNAKVLRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GP10</accession>
    <name>A0AAJ0GP10_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Zinc-finger of the MIZ type in Nse subunit-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0T15DRAFT_496057</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NSE2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719288.1">
        <property type="nucleotide sequence ID" value="XM_062867152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GP10"/>
    <dbReference type="GeneID" id="87885981"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16651">
        <property type="entry name" value="SPL-RING_NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026846">
        <property type="entry name" value="Nse2(Mms21)"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21330">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21330:SF1">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11789">
        <property type="entry name" value="zf-Nse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SP-RING-type" evidence="13">
        <location>
            <begin position="292"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="155"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="375"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="380"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="408"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3303508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="427" mass="48432" checksum="1B9BB14BC62A8974" modified="2024-07-24" version="1">MPRLLQRTRRPEAGAGHSTTDDAPLELPPYEPPSHPMDDKLKQKLASMYSSRETDSSRRQYEKHLSKSNALLFESVGSINEILFRRRQTLARKAAKRKDNEDKDESERTLEEYVAQLDAIITELTDSSEAALRSVIDYRAELEDQQVVLDKVVEGLDAQQPRPEPEAAKPRPKRAGKRRVAGSDGEDDEEGSDAEAAEEEDEAMEAEEERKPDVAPLVGVKELLEAARQAKMDEYEALSAYQRYAVNNDYIAFKNNWHSALHQDNGKVLPDASKWFGKDGRPRMTVEDAADEDDELVVEREILDLKCPLSLQRFKEPYSNHQCKHTFEKDAIMQFIRDNGGTAKCPVCSKDLRLKDLYLDEVILRKVRRAEEAARRGLDDTSDIEPEEDGDSSLVVGKSANVGKSSKVKNEKDRIRRGMEDIDEDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GP25</accession>
    <name>A0AAJ0GP25_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">26S proteasome subunit RPN7-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_439094</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719297.1">
        <property type="nucleotide sequence ID" value="XM_062865881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GP25"/>
    <dbReference type="GeneID" id="87884710"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005838">
        <property type="term" value="C:proteasome regulatory particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000013">
        <property type="entry name" value="Proteasome regulatory particle subunit (RpnG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000021">
        <property type="entry name" value="Putative proteasome regulatory particle subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019585">
        <property type="entry name" value="Rpn7/CSN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045135">
        <property type="entry name" value="Rpn7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049549">
        <property type="entry name" value="RPN7_PSMD6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145">
        <property type="entry name" value="26S PROTESOME SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10602">
        <property type="entry name" value="RPN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21154">
        <property type="entry name" value="RPN7_PSMD6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="229"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="103"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3303517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="491" mass="54431" checksum="7095859C850B0CB6" modified="2024-07-24" version="1">MGSDPQYAKWPLLPLAQQVFTLTNSYASRTSQQAAAKQLQDAISEHRMAPFYRYLAHPIDGILNVVGEGGANVPGKAPSRKNSAAGMIATRSATASINLPWDEELYQSLHADNERELEEYQKEEEEAVEKAGDTEIQAARGKRAEFWARVGDKEKAIAAYEDVFEKTGVLGTKIDLVLAIIRMGLFYGDKHLVKKHVERAKTLVESGGDWDRRNRLKAYEGLYLLTIRSYNLAAPLLLDSLSTFTSYELCTYSNLVIYSVLAGSVSLKRVDFKSKVVDAPEIRAILGDGEDKLLALTGAISAGPGADDAEMEVDASSATPAGSKVAVVNLTTLGSDQPEAEMAVDFGPLAQLVSSLYNGRYKLFFQALALVEEQFLTQDRYLHEHKNWFIREMRLRAYQQLLQSYRVVGLDSMANDFGVTVDFLDRDLAKFIAAGRIPCTIDRVAGNGVIETNRPDDKNKQYQDVVRQGDQLITKLQKYGQAVRLRGSERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQ36</accession>
    <name>A0AAJ0GQ36_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein S15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_485843</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719858.1">
        <property type="nucleotide sequence ID" value="XM_062866316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQ36"/>
    <dbReference type="GeneID" id="87885145"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_uS15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005290">
        <property type="entry name" value="Ribosomal_uS15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321">
        <property type="entry name" value="RIBOSOMAL PROTEIN S15, BACTERIAL AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321:SF26">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US15M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="49"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="208"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3304078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="314" mass="35170" checksum="75A0079D2E54D8B5" modified="2024-07-24" version="1">MPPRIPAPQGLRSLTLCLRPAPVAAPSFTPLVQAAKLSTKEKKRLMKQDPYGWAQAQQRKNANLKRREELEKERKAGWGDPVHGIVTPFVESFDTAGQQPVAGEGSASDEPHPLPTSPHIINNFLTKEELEQAIEHARRVTQPLVGEENTTSDPELETHELKEHEEKHAKALVALQRITDLKNASAKDRKHANIRRCIETFGRHVTDEKLENPAPPPARGVVPQPRPIRAGPDTGSSEVQIAILTSKIRALALALEGPKGHRDKNNKRSLRRLCHKRQKLLKYLERKERGSGRWQHLVETLGLTPATYKEQISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQ64</accession>
    <name>A0AAJ0GQ64_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RmlC-like cupin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_535555</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pirin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719882.1">
        <property type="nucleotide sequence ID" value="XM_062869501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQ64"/>
    <dbReference type="GeneID" id="87888330"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02247">
        <property type="entry name" value="cupin_pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02909">
        <property type="entry name" value="cupin_pirin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008778">
        <property type="entry name" value="Pirin_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903:SF8">
        <property type="entry name" value="PIRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903">
        <property type="entry name" value="PIRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05726">
        <property type="entry name" value="Pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin N-terminal" evidence="4">
        <location>
            <begin position="95"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin C-terminal" evidence="5">
        <location>
            <begin position="247"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3304102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="372" mass="40639" checksum="68138217CD99905E" modified="2024-07-24" version="1">MRTFSPVTVASISIIVGICSILAVLFSQDILSFTNASSSALLSHIFPADIKTSSNSSVTTTTNPNNMSTTSTRLIPRAIRQTFLAIEQSEGAGATVRRSIGTPRLRNLSPFLMLDHFSVSPGAGFPDHPHRGQETITYLLKGGIEHEDFAGHRGRLDPGDLQFMTAGRGIVHAEMPAQDTDVNVGLQLWVDLPKRLKQCEPRYRDLKADEVPQVDVDDGRVRVKVISGQSHGVDSVKDLAYTPVWLLDVEVKPGGKIVQPLPEGWTAFAYTLEGEVLIGEEGSQRTVGEFHNVVFESQGQAVYAAVDPGAEKSARFVLVAGTPLDQKVVQYGPFVLTSQEEVYQAFMDYQTHSNGFERANGWESEIGKSMVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQ88</accession>
    <name>A0AAJ0GQ88_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Ubiquitin elongating factor core-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0T15DRAFT_568125</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ubiquitin conjugation factor E4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719914.1">
        <property type="nucleotide sequence ID" value="XM_062870747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQ88"/>
    <dbReference type="GeneID" id="87889576"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034450">
        <property type="term" value="F:ubiquitin-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000055">
        <property type="entry name" value="Ubiquitin conjugation factor e4 a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019474">
        <property type="entry name" value="Ub_conjug_fac_E4_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045132">
        <property type="entry name" value="UBE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931:SF2">
        <property type="entry name" value="UBIQUITIN CONJUGATION FACTOR E4 B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931">
        <property type="entry name" value="UBIQUITINATION FACTOR E4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10408">
        <property type="entry name" value="Ufd2P_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0697">Rotamase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="12">
        <location>
            <begin position="1008"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3304134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1094" mass="122919" checksum="6D18C65EE5334D2E" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQF8</accession>
    <name>A0AAJ0GQF8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Ceramide very long chain fatty acid hydroxylase</fullName>
            <ecNumber evidence="18">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">B0T15DRAFT_226911</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Ceramide hydroxylase involved in the hydroxylation of sphingolipid-associated very long chain fatty acids. Postulated to hydroxylate the very long chain fatty acid of dihydroceramides and phytoceramides at C-2.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18 19">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="18 19">Binds 2 Zn(2+) ions per subunit that likely form a catalytic dimetal center.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the sterol desaturase family. SCS7 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="18"/>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719800.1">
        <property type="nucleotide sequence ID" value="XM_062862892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQF8"/>
    <dbReference type="GeneID" id="87881721"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080132">
        <property type="term" value="F:fatty acid 2-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000002">
        <property type="entry name" value="Cytochrome b5 type B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014430">
        <property type="entry name" value="Scs7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12863:SF1">
        <property type="entry name" value="FATTY ACID 2-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12863">
        <property type="entry name" value="FATTY ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005149">
        <property type="entry name" value="IPC-B_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 18" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="17 18" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="10 18" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 20" id="KW-0349">Heme</keyword>
    <keyword evidence="14 18 20" id="KW-0408">Iron</keyword>
    <keyword evidence="5 18" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="15 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16 18 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 18 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11 19" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="22">
        <location>
            <begin position="6"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="20">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="20">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR005149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR005149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR005149-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAK3304020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="372" mass="42098" checksum="80A9C366D7BFF9B7" modified="2024-07-24" version="1">MPGRTLPTFTLAEVESHNSRKSCFVTVGNNVYDVTDFVDSHPGGADLVLDYAGKDITDILKDEASHAHSEAAYEVLDDSLVGFLASANGTTKSASGNGLANGANGTNVHPRTGMSCEEDLTKDTDIASDYKTHKFLDLSRPLFPQVWNGGFSKEFYLDQVHRPRHYRGGASAPLFGNFLEPLTKTPWWVIPLVWVPPVCYGLYLASKGFSNPAGEVACFVAGLCLWTLIEYIMHRFLFHLDYYLPDNRVGITLHFTLHGIHHYLPMDKYRLVMPPTLFLALATPFWKLAHTIFFWNWHIATAVYCGGVFGYICYDLTHYFLHHQNLPLWWKQLKKLHLEHHFLDYENGFGVTSPFWDYVFGTELGPATKKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQK7</accession>
    <name>A0AAJ0GQK7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Plectin/S10 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_399888</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720031.1">
        <property type="nucleotide sequence ID" value="XM_062865031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQK7"/>
    <dbReference type="GeneID" id="87883860"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005326">
        <property type="entry name" value="Plectin_eS10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037447">
        <property type="entry name" value="Ribosomal_eS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12146">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12146:SF0">
        <property type="entry name" value="RIBOSOMAL PROTEIN S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03501">
        <property type="entry name" value="S10_plectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Plectin/eS10 N-terminal" evidence="7">
        <location>
            <begin position="2"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="58"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="74"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3304251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="118" mass="13403" checksum="59AA247E975A521F" modified="2024-07-24" version="1" fragment="single">ETGIRNLYVIKACQSLTSRGYVKTQFSWQYYYYTLTPEGLDYLREWLHLPAEIVPATHIKQQRSHAPPRGMLGGEERGERRFGGRGRGDRGDREGGYRRRDAGEGKEGGAPSDFAPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQT6</accession>
    <name>A0AAJ0GQT6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">General transcription and DNA repair factor IIH subunit TFB4</fullName>
            <shortName evidence="14">TFIIH subunit TFB4</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">RNA polymerase II transcription factor B subunit 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0T15DRAFT_240065</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 14">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the 7-subunit TFIIH core complex composed of XPB/SSL2, XPD/RAD3, SSL1, TFB1, TFB2, TFB4 and TFB5, which is active in NER. The core complex associates with the 3-subunit CTD-kinase module TFIIK composed of CCL1, KIN28 and TFB3 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the TFB4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720171.1">
        <property type="nucleotide sequence ID" value="XM_062863059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQT6"/>
    <dbReference type="GeneID" id="87881888"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000084">
        <property type="entry name" value="Transcription factor TFIIH subunit Tfb4, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004600">
        <property type="entry name" value="TFIIH_Tfb4/GTF2H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12831:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12831">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIH TFIIH , POLYPEPTIDE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03850">
        <property type="entry name" value="Tfb4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 14" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="292"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="100"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="314"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU368090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3304391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="433" mass="43764" checksum="8E166FE59CB7248E" modified="2024-07-24" version="1">MSVQDAVDASEHYEVHNTDDIPSLCTIIIDTNPRAWAALADVLPISKAIANVLIFVNAHLAFSNSNQVALIAAHTNRAVWLYPAAPKPAQSHSGDVDMQDASNGTKSASDIKSSSANKYPQFAQIENSVLTSLRALIDDTTAADLSATTPQISGALTLALAHINKTALSFTASATAANATATGAPKTAGTAVGAAPVASTSTSAGGLAGLHARILIISVSDSSPAQYIPTMNAVFAAAHARIAIDTLSLRGSATFLEQASFITRGTFVRAAEPQGLLQYLMFGFGSGSAPSNPAGGGGGGGAGKTKEPAAKSQAAANTANTTNGPVSGSGSGGGGGRPKTVQLGAGANVADLLVTPSADAVDFRAACFCHRNVVDIGFVCSVCLSIFCEVPEDAECLTCGTKLALGSYGKKPVVVDGAGRNDHQRRTGVNGQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQV6</accession>
    <name>A0AAJ0GQV6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">allantoicase</fullName>
            <ecNumber evidence="3">3.5.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_485940</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Utilization of purines as secondary nitrogen sources, when primary sources are limiting.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>allantoate + H2O = (S)-ureidoglycolate + urea</text>
            <dbReference type="Rhea" id="RHEA:11016"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:17536"/>
            <dbReference type="ChEBI" id="CHEBI:57296"/>
            <dbReference type="EC" id="3.5.3.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Nitrogen metabolism; (S)-allantoin degradation; (S)-ureidoglycolate from allantoate (aminidohydrolase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the allantoicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.4" evidence="3"/>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720010.1">
        <property type="nucleotide sequence ID" value="XM_062866325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQV6"/>
    <dbReference type="GeneID" id="87885154"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004037">
        <property type="term" value="F:allantoicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051020">
        <property type="term" value="F:GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000256">
        <property type="term" value="P:allantoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15473">
        <property type="entry name" value="Myo5p-like_CBD_DIL_ANK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000078">
        <property type="entry name" value="DAL2p Allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000059">
        <property type="entry name" value="Probable allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00813">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005164">
        <property type="entry name" value="Allantoicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015908">
        <property type="entry name" value="Allantoicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002710">
        <property type="entry name" value="Dilute_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037986">
        <property type="entry name" value="Myo5p-like_CBD_DIL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052072">
        <property type="entry name" value="Vascular_dev_regulator"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02961">
        <property type="entry name" value="allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027:SF6">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN YPR089W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03561">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01843">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01132">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51126">
        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="520"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="Dilute" evidence="10">
        <location>
            <begin position="741"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="850"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1042"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1149"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="376"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1046"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1065"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1161"/>
            <end position="1170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00056910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00060607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3304230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1170" mass="129872" checksum="D54385B3A4332DB2" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQV8</accession>
    <name>A0AAJ0GQV8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_242579</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720247.1">
        <property type="nucleotide sequence ID" value="XM_062863083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQV8"/>
    <dbReference type="GeneID" id="87881912"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000286">
        <property type="entry name" value="MFS efflux transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000308">
        <property type="entry name" value="MFS efflux transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051788">
        <property type="entry name" value="MFS_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514:SF3">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GR34</accession>
    <name>A0AAJ0GR34_9PEZI</name>
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        <submittedName>
            <fullName evidence="6">Ras guanine nucleotide exchange factor domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="6" type="ORF">B0T15DRAFT_503614</name>
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    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
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            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomium</taxon>
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    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
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                <person name="Hiltunen Thoren M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
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        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
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                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Kuo A."/>
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                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
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                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
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                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
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                <person name="Ament-Velasquez S.L."/>
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                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
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                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062867990.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87886819"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04514">
        <property type="entry name" value="Taspase1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.30:FF:000007">
        <property type="entry name" value="Similar to threonine aspartase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.30">
        <property type="entry name" value="(Glycosyl)asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000246">
        <property type="entry name" value="Peptidase_T2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037464">
        <property type="entry name" value="Taspase1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188:SF8">
        <property type="entry name" value="THREONINE ASPARTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01112">
        <property type="entry name" value="Asparaginase_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="180"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="202"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="218"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="2">
        <location>
            <begin position="275"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3304390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="457" mass="47768" checksum="3DD1489447B5D47C" modified="2024-07-24" version="1">MSFLKAGATATEAVEAAIRCLEDKEIANAGFGSNLNIDGVVECDATIVDHLGRSGACGAVPGVKNPISLAKKVLDTSTQPLSLGRVPPNLLVGQGAREFADAHGIKTTRNESLVSKNAMSRYLRWNEELKKAEAQRKARKSFFGDYSSGQRTPRKGDYENVANRAGIAALRDHTSAILMGTWNEGQPDSPDSGGSALGEHGSPAVAAAPASSHTSTPKQSVECTNVRSESPYLMTAPPPSASGHDGPGSSDTAEVDMADDFDPYGAETDEDMVTDTVGAIAIDLQGNIAAGSSSGGIGMKHRGRTGPAALVGVGTAVVPEDPDDDLATSVAAVTSGTGEHIATCSASGKCAERLFQGSRRGPGGRDIQEEDEHAILESFIVDDFLGHPGVRNQHTAGAIGVMAVKKDRTGAYFYFAHNTDSFALASMSSTEREPLCVMSRLGRTRQVAQGGRKVRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GR88</accession>
    <name>A0AAJ0GR88_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_400468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720454.1">
        <property type="nucleotide sequence ID" value="XM_062865062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GR88"/>
    <dbReference type="GeneID" id="87883891"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3304674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="398" mass="40953" checksum="DC5DA26A0C4EE44B" modified="2024-07-24" version="1">MADRPGRPGRRRPFSALMRKLANLKAASSGDGGRYSGSKRSSAKKRQNNPYSQAGRISASPSPRPSRHSGSSGESQRLASDGSPERIDSARISSDEQPPPTTGGRSIAPTVSTEHDTWRSMIAPSHGESSLADTSRTATARRGGDSTFSSPAPSVRSLTTTLTTQTIAPNNGGSNQTPTTTHHHSHPSTSQVIHFNQPFPTTTPASAIPPHLATSTTVHPTTYATATANNLLTDNASILTLASSSQRRRRRSLDTDASVRALAPSSLWGGSRESLPLSVLSATMDGTAGGPPTTPGLHRGPSAAGLAGMGNERTSIYSATGILAAASERNSIYAKALAGDAASVRSGLLGHGRADSVSGSISGGGLGTVPAGTSPLASPREVPGEGEILENGFEEEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GRC9</accession>
    <name>A0AAJ0GRC9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carbohydrate-binding module family 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_419065</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720519.1">
        <property type="nucleotide sequence ID" value="XM_062865519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GRC9"/>
    <dbReference type="GeneID" id="87884348"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041524">
        <property type="entry name" value="GH131_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34612">
        <property type="entry name" value="GH131_N DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34612:SF6">
        <property type="entry name" value="GLYCOSIDE HYDROLASE 131 CATALYTIC N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18271">
        <property type="entry name" value="GH131_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042552514" evidence="5">
        <location>
            <begin position="19"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="6">
        <location>
            <begin position="309"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="259"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="269"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3304739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="345" mass="36805" checksum="105B39047873DC6D" modified="2024-07-24" version="1">MKFAVLSSLVANALSVSAGTVLWDGRFNDLSSSTDLNKWSWGNQVGPYQYYIHGSSEVTAYVNLSPDYKNPADTNSKQGAKITLDSTAYWNGQNMRRTELIPQTSAPINKGKVYYHFSLMRKDTNAPATTREHQIAFFESHFTELKSGLLSGAAGESDTSLRWCVGGQTKWSTEWVAGVWHNVAYEIDFDANTVGFWHSTGSDPLTQVIAPVSASTSSNGADWHVGVLELPRSGYADTTEDYYWSGVYIESGSLTTAIGSGSAPGGGSSSSSAPVSSSTKAPVSSSTTLVTSTTKTSAAPATSTTPSGCTASQWSQCGGNNFSGCKTCAAPYTCKFVNDWYSQCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GRD6</accession>
    <name>A0AAJ0GRD6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative lipoate-protein ligase A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_250525</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LplA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720457.1">
        <property type="nucleotide sequence ID" value="XM_062863170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GRD6"/>
    <dbReference type="GeneID" id="87881999"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017118">
        <property type="term" value="F:lipoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16443">
        <property type="entry name" value="LplA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004562">
        <property type="entry name" value="LipoylTrfase_LipoateP_Ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561">
        <property type="entry name" value="LIPOATE-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561:SF3">
        <property type="entry name" value="LIPOYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21948">
        <property type="entry name" value="LplA-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="5">
        <location>
            <begin position="71"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3304677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="457" mass="51045" checksum="AF9E3BB3F0324B57" modified="2024-07-24" version="1">MMAPTSRLGVITRRIPLSRPQCQSRPKVITSPAQTRPYTQHLSKPVQIYRSTSTDPYLNLSIEHHLLQRSHPDSTILFLYTNRPSVVIGRNQNPWVEVNMRRLRVGLPTSSSPYAEEDFYGRPHANVKTIPVSLVRRRSGGGTVFHDAGNTNWSVICPPAVFDRDRHAEMVVRALRRLGVADVRVNERHDIVRDLDVPYVGRRAVKVSGSAYKLTRTRSLHHGTCLLRSKNLGHISELLHSPAEDLIKARGVESVRSPIGNVGVGGEEFADAVVGEFQRMYGGESTGGGVVVGEEEALAMEDVVKGLRELTSPEWIYGQTPQFTFSTHPTEDDPRERPSKWRLMSHKFRAHFTVRHGVIQSAKLSGLRYRNPDAGGSPDEILSKALVNQRIHHIKDWRTTLQQASSRIVDVNDLGEWLNDAFGLQTPGIKGDLSVADATVEMLAQTEVGRYLSKNTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GRF0</accession>
    <name>A0AAJ0GRF0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_419132</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720549.1">
        <property type="nucleotide sequence ID" value="XM_062865523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GRF0"/>
    <dbReference type="GeneID" id="87884352"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF167">
        <property type="entry name" value="FI17812P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="10">
        <location>
            <begin position="35"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="9">
        <location>
            <begin position="504"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="595"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="597"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3304769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="722" mass="79666" checksum="E21151FACAEEAE98" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GRZ3</accession>
    <name>A0AAJ0GRZ3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_537651</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720580.1">
        <property type="nucleotide sequence ID" value="XM_062869632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GRZ3"/>
    <dbReference type="GeneID" id="87888461"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3304800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="297" mass="32366" checksum="ADD575F9D62FB374" modified="2024-07-24" version="1">MESSQNDETPLPPAAAFALDIGLSQTGDAGSSYHFQNDPSDPLQRKNWTERKGVVDIRATCLDVVHGVLGEQTPVFCTLLVLEFCFDPRKQGRRILSAEIELRFSGSKAGGGSDIEVAQISPVGRLSLVPSSQEETTTLETEVSAGSASSLPVDVGAGWKWSRSVSRTVNDAATIVGSIDMLGRTWGKKNSASWTLMENRMTKSGVPSMMRAAVRLHRQTEEPFTCEFGIRAKADWQTSLTNLLGSTPPDDPVFFDPTLPSTNNLQEYDELALGSLDLESLSDITHLTIFENAMKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GS12</accession>
    <name>A0AAJ0GS12_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_383696</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720858.1">
        <property type="nucleotide sequence ID" value="XM_062864264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GS12"/>
    <dbReference type="GeneID" id="87883093"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001638">
        <property type="entry name" value="NACHT and WD40 domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
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        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF13">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NACHT" evidence="3">
        <location>
            <begin position="304"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="2">
        <location>
            <begin position="832"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="2">
        <location>
            <begin position="874"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="2">
        <location>
            <begin position="916"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="944"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3305078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="944" mass="106157" checksum="FC9BAEEF8C91634A" modified="2024-07-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GS68</accession>
    <name>A0AAJ0GS68_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_368905</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720921.1">
        <property type="nucleotide sequence ID" value="XM_062864185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GS68"/>
    <dbReference type="GeneID" id="87883014"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3305141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="62" mass="7007" checksum="12ED5F92ED69C478" modified="2024-07-24" version="1" fragment="single">RALTNDADALRAMAGILRRLSQRSRCRMLQGLPTGLFDKYVLLRGPVAGRRRGFPSYSWAGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GSC4</accession>
    <name>A0AAJ0GSC4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_186659</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3304995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720775.1">
        <property type="nucleotide sequence ID" value="XM_062862385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GSC4"/>
    <dbReference type="GeneID" id="87881214"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3304995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="321" mass="35251" checksum="67F75BD659D6B40D" modified="2024-07-24" version="1">MSVISSTCRHSLSGRSRSALLVCFYPVQHATKPAIRRTKCTASSAFHRTLGFLQKSRSVTTGLSATSTCVRLSGSGKKIKHLISLAEHTPSDCYTRNSGLTCLLGPLNSRCRAVISPLSIACSLSAPKAGKRRLARSNLLGTPLPPAASSTSTHKTITVTGFQVDEIGCIEDRIKDIVPDYTSEAMTRICKRICWDQPDQEFESELEHFWRAYLGPEPAQASSWAVAEVDAMPRRLLDLKCFKTAQHKLIGMTDAAVGVGDVVCGLFGLRVPVILRKNSDTTGPNTADVRSPQERRLFRSSKWDRWPPTCTAPALRPRVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GSE2</accession>
    <name>A0AAJ0GSE2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Extracellular serine-rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_493415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721014.1">
        <property type="nucleotide sequence ID" value="XM_062866944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GSE2"/>
    <dbReference type="GeneID" id="87885773"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00920">
        <property type="entry name" value="Cupredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052953">
        <property type="entry name" value="Ser-rich/MCO-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883:SF15">
        <property type="entry name" value="EXTRACELLULAR SERINE-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883">
        <property type="entry name" value="SERINE-RICH PROTEIN, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042525883" description="Extracellular serine-rich protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3305234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="20707" checksum="3383925577CA4EBA" modified="2024-07-24" version="1">MFSQALLLLAAALPLISAAPAPNPTLGQRAPDGTAASPRTTHTVVAGRPGLRFDPENVVAEVGSIVEFHFLQLNHSVAEASFDSPCQPKDAGVAGSFFSGFFPVPRNADGSASQSGEVFQIEVRDADRPIWFYCAQNTGRHCQSGMVGVVNQRFDEAEKTLDVFRSKAAMVQGPSGVQPLVQGGWRGANPNPLGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GT01</accession>
    <name>A0AAJ0GT01_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_567482</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721373.1">
        <property type="nucleotide sequence ID" value="XM_062870728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GT01"/>
    <dbReference type="GeneID" id="87889557"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052400">
        <property type="entry name" value="Zn2-C6_fungal_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657:SF7">
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                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
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                <person name="Chen C."/>
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                <person name="Debuchy R."/>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <person name="Labutti K."/>
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                <person name="Chen C."/>
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                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Lipzen A."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721655.1">
        <property type="nucleotide sequence ID" value="XM_062867930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GTW7"/>
    <dbReference type="GeneID" id="87886759"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01833">
        <property type="entry name" value="XynB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051532">
        <property type="entry name" value="Ester_Hydrolysis_Enzymes"/>
    </dbReference>
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        <property type="entry name" value="FN3_dom"/>
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        <property type="entry name" value="FN3_sf"/>
    </dbReference>
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        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383:SF19">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383">
        <property type="entry name" value="THIOESTERASE 1/PROTEASE 1/LYSOPHOSPHOLIPASE L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="360"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3305875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="582" mass="63442" checksum="1D54FB107C971B88" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GU90</accession>
    <name>A0AAJ0GU90_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_526878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722072.1">
        <property type="nucleotide sequence ID" value="XM_062868929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GU90"/>
    <dbReference type="GeneID" id="87887758"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37538">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37538:SF4">
        <property type="entry name" value="PITSLRE SERINE_THREONINE-PROTEIN KINASE CDC2L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="223"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3306292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="511" mass="56582" checksum="DF85F3C81BCE1FF6" modified="2024-07-24" version="1">MEVMRETAGDNPEISPYTSEFINLEFANAALEFAVHHEVLQRSSKLSTLPKVKVKKTKVINLRQFSYIAGHALVHYLYTNQLHVLDWGETKLSEFKSKLEIYALARTFELSGLEELVRDDMERCAHDLDLFSIIDAVAEAYPNPIGDDAWLPQWFKSHMKKAFRDPRTLSKTPVAPVFSDGSSVIKLFLGCMLETYADMVNSLACPGADVEKNDEKQELLAAAPEAEGEASAPAQPVLDSGPESEPARPLTPLAEFFQKLMKRGMKASAQAESELEMEPHPEAEPEPSMEAEPDLAPELDYGAAPEPEPEPEPEAKLESVCNCSECSPVPVCEPEPEPEPEPEPEPEPEIDPDSEAESEPPMEAEPNLVNEPDYEPGPEPEPVDKPGLCCNCSECSPASVEEEERRAEEAGNFALERGTKQKVMKAKKAMKAKNAKNAKPKARRAQMAKELIAAEPEPAPERELEPMSSEVVVEDEVKRDPWEFWGAKRSPTARKTSGESLASWDRVGDGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GUQ8</accession>
    <name>A0AAJ0GUQ8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartate aminotransferase</fullName>
            <ecNumber evidence="7">2.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_394857</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21824"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="EC" id="2.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="7"/>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722212.1">
        <property type="nucleotide sequence ID" value="XM_062864749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GUQ8"/>
    <dbReference type="GeneID" id="87883578"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006532">
        <property type="term" value="P:aspartate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000064">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000001">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF55">
        <property type="entry name" value="GLUTAMATE OXALOACETATE TRANSAMINASE 1, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="8">
        <location>
            <begin position="36"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3306432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="419" mass="46058" checksum="F9D333F1E4D33035" modified="2024-07-24" version="1">MAPPSVTNFPAEVVPQAPEDPLFGLMRAYRADPSPDKVDLGIGAYRDDNAKPWVLPVVKKADEILRNDPEANHEYLPITGLAALTGKAAELLLGKSAPAIAEKRVSSVQTISGTGAVHLGALFLAKFYKIQGTNRTVYLSNPTWANHHQIFTNVGLPIATYPYFSKETKGLDFEGMKAALREAADGSIILLHACAHNPTGVDPTPEQWRDIALLMKEKKHFPFFDTAYQGFASGDLDRDAGAIRLFVEEGFELVIAQSFAKNFGLYGERAGCFHYVASPSSDAAEITTRVASQLAILQRSEISNPPIYGARIASIVLNDSTLFAEWQDNLRTMSGRIISMRTALRDKLEKLGTPGKWNHITDQIGMFSFTGLTEAQVLKLRQNYHIYMTKNGRISMAGLNSKNVDYVANAIDKVVREVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GV16</accession>
    <name>A0AAJ0GV16_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_138512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722155.1">
        <property type="nucleotide sequence ID" value="XM_062861851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GV16"/>
    <dbReference type="GeneID" id="87880680"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13668">
        <property type="entry name" value="Ferritin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042612175" evidence="1">
        <location>
            <begin position="19"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3306375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="386" mass="42029" checksum="53193E3A2C4844D4" modified="2024-07-24" version="1">MHWLTFFLAASTLLAAKAAVLPRCAQCNVPPQYSGEAQKLADPTYGPIPGASDLYSSYWGIERPFPGNITDPVFPTENGPPGEDDYIWQNLLSAEWIIFEFYQQGIERFSDQDFIDAGMPNTTRRRLMEIRNNEAGHLRIFQNQISPTSIKPGPCRYMFPLDEPLAYLSFLTVIELASMAFLTGLAQLPRSDFAKGAMTAISQTETRHELWALTDLWKTEPFAGPTDTTFPYANQILYSTHNLVVPGSCPPENPEYPHPRQLLPILSATPNTTSLAPGATITLHFPESESDSQHQPAFFKDGKQYYAVFFHGVLNASVPIDTGSGSGSGPISVTIPPEFEAKGAIIALVADEPGAPTNYSVVAGPAVIPMQPAWLGPALVRGGGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GV45</accession>
    <name>A0AAJ0GV45_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class I glutamine amidotransferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_528110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722507.1">
        <property type="nucleotide sequence ID" value="XM_062869016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GV45"/>
    <dbReference type="GeneID" id="87887845"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01741">
        <property type="entry name" value="GATase1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044992">
        <property type="entry name" value="ChyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695:SF5">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="1">
        <location>
            <begin position="55"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3306727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="250" mass="27900" checksum="53EF9D78720343FC" modified="2024-07-24" version="1">MPSIPLRLAILEADTPVPRANERYHGYLGVFKHLFERAAHPVPLESVVRLTGHDVVHNPASAYPSLDDVDAILISGSKHNSFDNDEWIGTLVEYARKALAHPRVRVIGVCFGHQIVARAMGALVGRSDEGWEVSVTETRLTEKGKELFGGRETLKVQQMHRDKVFSVPAGAELLASTEKCMNHGFLIPKRVITVQGHPEFTEDIMQEILELRHESGLLTDEVYQSGMARNGEHHDGILMAQVFLKFLQEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GVD5</accession>
    <name>A0AAJ0GVD5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NECAP PHear domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_144898</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722335.1">
        <property type="nucleotide sequence ID" value="XM_062861922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GVD5"/>
    <dbReference type="GeneID" id="87880751"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012466">
        <property type="entry name" value="NECAP_PHear"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12847">
        <property type="entry name" value="ATP-BINDING CASSETTE ABC TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12847:SF9">
        <property type="entry name" value="NECAP-LIKE PROTEIN CG9132"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07933">
        <property type="entry name" value="DUF1681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NECAP PHear" evidence="2">
        <location>
            <begin position="21"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3306555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="308" mass="32717" checksum="022412726F23C0E0" modified="2024-07-24" version="1">MDVPATIDPATGRPLPPDAIVRILHITPKVHVYSIPRDSVATAAGYAAASWTSDPRNHIFTARLRVLETSFSTSSSSSASEEQQQQQQRQTSEEEDEEMQIKIDILLEDPSTGALFAAAPYTTPASVEPTTDSSRFFAVRVQDPTSKQKATLGVGFEERSEAFDFGVALQEAGRALRWSSSSSSSAASSSQSHHITRAVGGTGGTGGEAGVTASKGKGGGEEEEKRDLSLKEGETITVNLSGTRFGRRAGRQQQSEEDTKGSGGEEGKSLASFSLPPPPPPSAREVRAQKRLSAQQLGFDDGQFGEFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GVE2</accession>
    <name>A0AAJ0GVE2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_492232</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722480.1">
        <property type="nucleotide sequence ID" value="XM_062866848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GVE2"/>
    <dbReference type="GeneID" id="87885677"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04516">
        <property type="entry name" value="TBP_eukaryotes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000005">
        <property type="entry name" value="TATA box-binding protein-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033710">
        <property type="entry name" value="TBP_eukaryotic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3306700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="237" mass="26719" checksum="3279ECEB1FC332E4" modified="2024-07-24" version="1">MNTHSQSATTTSSPPSTQSFPDQDRPWRERLKPDWPLPQIQNVVATCNLDCRLDLAVIAQHARNVEYNREKFHALIMRIREPRTTTLVFASGRLVVTGAKSAGLARLAARRHARAIQKCGFRTSFRDFAVQNFVGSVSCGFHIRLEGLARRAYQSCTHEPELFPGLVFTMMKPKLKCLVFTTGKVVFTGAKSEDQVYEAFANLYPLLLDFRVNSVAAVPPWLKETAPKAEARSKRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GVQ4</accession>
    <name>A0AAJ0GVQ4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_553386</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722813.1">
        <property type="nucleotide sequence ID" value="XM_062870316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GVQ4"/>
    <dbReference type="GeneID" id="87889145"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14723">
        <property type="entry name" value="ZIP_Ppr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000006">
        <property type="entry name" value="Positive regulator of purine utilization"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF1">
        <property type="entry name" value="PYRIMIDINE PATHWAY REGULATORY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="74"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="150"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="224"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="764"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="866"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="994"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="764"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="867"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="900"/>
            <end position="913"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3307033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1020" mass="111122" checksum="95B983096FC032D7" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GVU2</accession>
    <name>A0AAJ0GVU2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_566681</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="6"/>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722851.1">
        <property type="nucleotide sequence ID" value="XM_062870703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GVU2"/>
    <dbReference type="GeneID" id="87889532"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033096">
        <property type="entry name" value="PPPtase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="8">
        <location>
            <begin position="108"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="188"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR033096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3307071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="425" mass="45983" checksum="48D0AA69A680A89C" modified="2024-07-24" version="1">MSDLDRWIAQLRACRPIAESEVRELCHKARELLIEEGNVVTINAPVTICGDIHGQFHDLMELFRVGGDVPDTNYLFMGDFVDRGFYSLESFLLLLCLKVRYPDRMTLIRGNHESRQITTVYGFYDECLRKYGSANVWRYCCDVFDYLALGAIVLGASNTVGGQPDDVEIEIHNSDGQVISRFLRQKGADNNRLGGKGGGTPNGTAATANGAPPPASAPPSLTGPPGSGASGSSSGSIGNPAGAVLCVHGGLSPLIDKVDKIRLLDRKQEVPHEGAMCDLLWSDPDEIDGWGLSPRGAGFLFGADIVKVFNHRNDLSLIARAHQLVMEGFKEMFDASIVTVWSAPNYCYRCGNVAALLELSEDESGLGVLARSNGEVNRSDGGGMLMEGDLLAPRTGPARKYRVFQAAPQDSRGMPAKKPVADYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GWT3</accession>
    <name>A0AAJ0GWT3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_554235</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723230.1">
        <property type="nucleotide sequence ID" value="XM_062870347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GWT3"/>
    <dbReference type="GeneID" id="87889176"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF236">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3307450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="16859" checksum="7A29F3634AC83A3F" modified="2024-07-24" version="1" fragment="single">EDRLDILFNNVGVIVSLSTEPPPKTAQGYKLALGVNYIETLLFIKLLTAVLATTAKSRTGPGIVRVVWLSSFALELFAQPNVGVALDNLDYHVPKPGQERYGISKVGVWALAVEYARRHRNDGIVSVAINPGNPTSELPRHQGVVLKTVARLVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GWV6</accession>
    <name>A0AAJ0GWV6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Pre-mRNA splicing factor component-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0T15DRAFT_433189</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in pre-mRNA splicing and cell cycle control.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CEF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723339.1">
        <property type="nucleotide sequence ID" value="XM_062865767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GWV6"/>
    <dbReference type="GeneID" id="87884596"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11659">
        <property type="entry name" value="SANT_CDC5_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000021">
        <property type="entry name" value="CDC5 cell division cycle 5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047242">
        <property type="entry name" value="CDC5L/Cef1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021786">
        <property type="entry name" value="Cdc5p/Cef1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047240">
        <property type="entry name" value="SANT_CDC5L_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45885">
        <property type="entry name" value="CELL DIVISION CYCLE 5-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45885:SF1">
        <property type="entry name" value="CELL DIVISION CYCLE 5-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11831">
        <property type="entry name" value="Myb_Cef"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="11">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="10">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="10">
        <location>
            <begin position="53"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="11">
        <location>
            <begin position="57"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="109"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="244"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="424"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="491"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="244"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="495"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00055157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3307559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="781" mass="87536" checksum="D56A3B965A765E91" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GXG4</accession>
    <name>A0AAJ0GXG4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_523147</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3307972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723752.1">
        <property type="nucleotide sequence ID" value="XM_062868671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GXG4"/>
    <dbReference type="GeneID" id="87887500"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.60.10">
        <property type="entry name" value="Penicillin V Acylase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047794">
        <property type="entry name" value="C45_proenzyme-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047801">
        <property type="entry name" value="Peptidase_C45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005079">
        <property type="entry name" value="Peptidase_C45_hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040521">
        <property type="entry name" value="C45_proenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34180:SF1">
        <property type="entry name" value="BETA-ALANYL-DOPAMINE_CARCININE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34180">
        <property type="entry name" value="PEPTIDASE C45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03417">
        <property type="entry name" value="AAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C45 hydrolase" evidence="2">
        <location>
            <begin position="149"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3307972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="472" mass="53155" checksum="E6DD9390850F55C5" modified="2024-07-24" version="1">MTRTCPHGKLTTFLAQGIPSEQIEPLTVVVREVCSQLIIQHYIPSLRDQWLIGFDEMRGIALGSGVPLERVVFLNVWEDLAAIGHIGKSGDRRGGRPPQPQDADESISAFFSPTATVDGETVLAHSLSSSKKIQDENLMVYLEIRYPEADFPTIFTVVEAGMISGCGMNSAGLAVTANCLWSTDDHLPQTGRGFYFPVTCMQRFLLESSDIHEAQAAIHDMRRHASKHVLLADESRSLSLELGPEHVFTHHARYDSKAKVHTNHFQSFEAFQWRRQILDRYQGKSSQARLYRLEHLIDDRVPDRMSRQDIVDVFSDHNGDVQSICQHNDEGCQDRTTVSFVMFNPKRKTISACKGPPCEGQMMHFTLETAAEAAARKQQEEAARRLRGSGGMRRRVREEMDMETPRSRAPSPPNHRFDGLVYPSPVGVTSSLDAMFSLTTKDFEKLESVRKEKRKAKEPTGARMKSTKRKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GYK7</accession>
    <name>A0AAJ0GYK7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="10">2.7.8.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0T15DRAFT_390359</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12593"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60110"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the CDP-alcohol phosphatidyltransferase class-II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.5" evidence="10"/>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724328.1">
        <property type="nucleotide sequence ID" value="XM_062864535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GYK7"/>
    <dbReference type="GeneID" id="87883364"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09135">
        <property type="entry name" value="PLDc_PGS1_euk_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09137">
        <property type="entry name" value="PLDc_PGS1_euk_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016270">
        <property type="entry name" value="PGS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586:SF1">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000850">
        <property type="entry name" value="Phospholipase_D_PSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="11">
        <location>
            <begin position="186"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3308548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="531" mass="59087" checksum="D26D61F01DF13D04" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GYT6</accession>
    <name>A0AAJ0GYT6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Adenylate kinase isoenzyme 6 homolog</fullName>
            <shortName evidence="10">AK6</shortName>
            <ecNumber evidence="10">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Dual activity adenylate kinase/ATPase</fullName>
            <shortName evidence="10">AK/ATPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0T15DRAFT_524940</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. Involved in the late cytoplasmic maturation steps of the 40S ribosomal particles, specifically 18S rRNA maturation. While NMP activity is not required for ribosome maturation, ATPase activity is. Associates transiently with small ribosomal subunit protein uS11. ATP hydrolysis breaks the interaction with uS11. May temporarily remove uS11 from the ribosome to enable a conformational change of the ribosomal RNA that is needed for the final maturation step of the small ribosomal subunit. Its NMP activity may have a role in nuclear energy homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with small ribosomal subunit protein uS11. Not a structural component of 43S pre-ribosomes, but transiently interacts with them by binding to uS11.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the adenylate kinase family. AK6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="10"/>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724442.1">
        <property type="nucleotide sequence ID" value="XM_062868808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GYT6"/>
    <dbReference type="GeneID" id="87887637"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000372">
        <property type="entry name" value="Adenylate kinase isoenzyme 6 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00039">
        <property type="entry name" value="Adenylate_kinase_AK6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020618">
        <property type="entry name" value="Adenyl_kinase_AK6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595:SF0">
        <property type="entry name" value="ADENYLATE KINASE ISOENZYME 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595">
        <property type="entry name" value="POS9-ACTIVATING FACTOR FAP7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13238">
        <property type="entry name" value="AAA_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 10" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMPbind" evidence="10">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="10">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="11"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3308662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="207" mass="23922" checksum="3AA5E680BF42A82F" modified="2024-07-24" version="1">MYIPLDQTPKPLDKLEPHSCRRGDDRATKENHKMSRSLPNVIITGTPGTGKTSHCELLAERTGLKHISVNDVVKDRECHEGWDEEYQSWIVDEDKLLDAIEDEVKQGGCIIDWHACDLFPKSWIDLVVVLRVDTATLYDRLTARKYPEVKLQENIDSEIMDVLLQEAKESYDEEIVVELQSVTADEMESNVERIEQWLEQWKKNNAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GYU4</accession>
    <name>A0AAJ0GYU4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_523980</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724040.1">
        <property type="nucleotide sequence ID" value="XM_062868732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GYU4"/>
    <dbReference type="GeneID" id="87887561"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF31">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="3"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3308260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="322" mass="34854" checksum="5318BB87C3686102" modified="2024-07-24" version="1">MAPTILVVGATGNTGRSVVETLSKFLNGSDNTTLPDHQVVALTRSLNNPVAQHLATLPGVQVLEHNWVDITADWLRGHQVVRAFIASPVQPSQFAEESAFHLAALRAGVQYVVRISTTAPNVRPDFPAFYPRQHWALEVMLGSPEFAGLQWTSLQPNVFTNFYLATSVEWIKQVRKTGKQDTPLRLMASKDAPVGVIHPDDVGEFAAKLLVQRDTAAHNKAKYVLNGPEDVTGEQIVRMVEQYIGAQVENVVYKDVTMVDGMAAAAEAAGQSKSIILSIKHGPVAAWEGKCTAATTSKEVLELAPPTRTVAGAFKALLEDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GYW9</accession>
    <name>A0AAJ0GYW9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_525015</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724464.1">
        <property type="nucleotide sequence ID" value="XM_062868813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GYW9"/>
    <dbReference type="GeneID" id="87887642"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02662">
        <property type="entry name" value="Peptidase_C19F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF888">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="10">
        <location>
            <begin position="153"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="259"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="545"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="272"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="580"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3308684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="778" mass="85523" checksum="C48998EDE0292CB9" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GZR6</accession>
    <name>A0AAJ0GZR6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GCS light chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Gamma-ECS regulatory subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Gamma-glutamylcysteine synthetase regulatory subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glutamate--cysteine ligase modifier subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0T15DRAFT_132764</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterodimer of a catalytic heavy chain and a regulatory light chain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family. Glutamate--cysteine ligase light chain subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3309176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724956.1">
        <property type="nucleotide sequence ID" value="XM_062861764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GZR6"/>
    <dbReference type="GeneID" id="87880593"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017109">
        <property type="term" value="C:glutamate-cysteine ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035226">
        <property type="term" value="F:glutamate-cysteine ligase catalytic subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032963">
        <property type="entry name" value="Gclm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13295">
        <property type="entry name" value="GLUTAMATE CYSTEINE LIGASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13295:SF4">
        <property type="entry name" value="GLUTAMATE--CYSTEINE LIGASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="11">
        <location>
            <begin position="112"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="53"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3309176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="330" mass="35755" checksum="3A626705C2A13408" modified="2024-07-24" version="1">MTKLILSTGNIVSGGPSIIRKPGAFRSNLELTNSLRSNFVAAQEDAAAELDARGATNGNGDTNGSGDSVDSDAETGTPRRVPTTAWTGRGQNGALYVPRIHWDHDHHQGLQEERAQYDITVKLFFLPGAPVSERSRYAREALEHVLQELRVPEVDLLIVSFPGMSFEGDCEWEADRKNAVQGNDEDEIATWPAIEELHRLSLAKRLGLAEFGSEKLARFLSKAQVRPTVNQINLKNCCNVPPPLAQLAKEQGIELLVHSDCTDILPKGTLRELLGPGPRGAAILADSETGAGGLQGDLTPLWVVKYTAVVRDRGVIESKGYFAGAELADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H089</accession>
    <name>A0AAJ0H089_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase</fullName>
            <ecNumber evidence="3">1.1.1.302</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_515496</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes an early step in riboflavin biosynthesis, the NADPH-dependent reduction of the ribose side chain of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NAD(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27274"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58890"/>
            <dbReference type="ChEBI" id="CHEBI:59545"/>
            <dbReference type="EC" id="1.1.1.302"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NADP(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27278"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58890"/>
            <dbReference type="ChEBI" id="CHEBI:59545"/>
            <dbReference type="EC" id="1.1.1.302"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HTP reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.302" evidence="3"/>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725221.1">
        <property type="nucleotide sequence ID" value="XM_062868199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H089"/>
    <dbReference type="GeneID" id="87887028"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="entry name" value="Dihydrofolate Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050765">
        <property type="entry name" value="Riboflavin_Biosynth_HTPR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38011:SF11">
        <property type="entry name" value="2,5-DIAMINO-6-RIBOSYLAMINO-4(3H)-PYRIMIDINONE 5'-PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38011">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_8G06820)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="Dihydrofolate reductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="domain" description="Bacterial bifunctional deaminase-reductase C-terminal" evidence="10">
        <location>
            <begin position="5"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3309441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="214" mass="23332" checksum="9CDB186DC9DA2B9B" modified="2024-07-24" version="1">MPRLLRYNLAPTLNGLIATLPSHSHAWIVPDASIDFAALYAEFDTFVMGRKTYETFLSLPAHENPLVGRAKEDVVVVTGGSQGGRRKEGWGDVTVIGSQGDAEVVRFVRRLKEEDAAASPGKEKKKDIWLMGGGRLAGLLMREGLVDVVEAAIMPVVIERGVGMFADGGEGTEEGERVWKLKLESVRAMESGIVMTRYRVVHEQGWTSGAHDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H0B1</accession>
    <name>A0AAJ0H0B1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_488206</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725256.1">
        <property type="nucleotide sequence ID" value="XM_062866485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H0B1"/>
    <dbReference type="GeneID" id="87885314"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048666">
        <property type="entry name" value="RedAm-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21761">
        <property type="entry name" value="RedAm-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="1">
        <location>
            <begin position="4"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="NADPH-dependent reductive aminase-like C-terminal" evidence="3">
        <location>
            <begin position="170"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="316"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3309476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="507" mass="54847" checksum="39F971DCA809698E" modified="2024-07-24" version="1">MSTVTSIGIGNMGAAIATALLKSSVKLTLWNRTASRPQVQAVMAAGATFESSLSAAIAASEVVLLCVLDYPVLSAIFSQLDPATRPLQGKTVLNLTNGTPKQARDMEAYMKTTLGAAAYLDGGIMVTPQLVGTPASFLVLSGESEAVYRARLADTALLEPVGKLLYISPDAGAASLVDCAALAAMYGMFVGAFTGIGLLKRQKGLGDQDGKKKGLAVKPLVDGVMVSLLKELVPYVSLLADQIDREDWMDDLGNPLAMQAVGVRNIMQSCEEEGVDGSGLAFLSGLMDKAVQDGFGTGGVAVVAKYLMNSSDRPPYAILSHTWGPEEVTFQDITSPERAQKKGFAKIEGCCRRARADGLHWVWVDTCCIDKTSSAELSEAINSMYAWYRDSAVCYVYLKDVVKGDGFPLEDFLSARWFTRGWCLQELIAPRAVEFYATDWSEIGTKFSRCEDIERRTSIPRSVLLRQDLDQCSIAQKTSWASERQTTRIEDEAYCLLGLFGVHMPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H140</accession>
    <name>A0AAJ0H140_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Basic proline-rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_5467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725315.1">
        <property type="nucleotide sequence ID" value="XM_062870160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H140"/>
    <dbReference type="GeneID" id="87888989"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="306"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3309535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="326" mass="35002" checksum="D140C6F89C096C1A" modified="2024-07-24" version="1">MEPVPETERMEEFRPSPLPSLRLQGTASGGSHENDFLRKPPTIRRSTDPSPSSPISPSWMPPALPYRPRASSPLSSNHVRSRSAASLAPPMARTQSMPSTNATGHLLYSPQLRPQSPAGSPSRIRIPRKPIDEGFPSSPTRVSVLDPQRKLSERSSSPNLALGIAPPTTMPKVRRPSSPLFQVAHVSNGSIPGAIPTTPSSIGNSPSYRSYDSFSGSYASSAIYPSSSVPSTPTSARSRSPSISSLETIPDSPDAEEAALEAERIAQLKAAADAAEGGDAKGRSSLDMPIRGRTLTGFSSRDKRKRWSVCGAERRQDLDLETIWED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H1C2</accession>
    <name>A0AAJ0H1C2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Rap1-interacting factor 1 N terminal-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_516181</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725465.1">
        <property type="nucleotide sequence ID" value="XM_062868242.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87887071"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140445">
        <property type="term" value="C:chromosome, telomeric repeat region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022031">
        <property type="entry name" value="Rif1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22928">
        <property type="entry name" value="TELOMERE-ASSOCIATED PROTEIN RIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22928:SF3">
        <property type="entry name" value="TELOMERE-ASSOCIATED PROTEIN RIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12231">
        <property type="entry name" value="Rif1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="Telomere-associated protein Rif1 N-terminal" evidence="8">
        <location>
            <begin position="152"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="40"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1087"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1448"/>
            <end position="1666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1090"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1149"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1164"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1250"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1274"/>
            <end position="1285"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1369"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1415"/>
            <end position="1429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1448"/>
            <end position="1457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1488"/>
            <end position="1506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1517"/>
            <end position="1527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
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            <end position="1552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1577"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1589"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1611"/>
            <end position="1621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1634"/>
            <end position="1643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3309685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1754" mass="193486" checksum="0DC5F9CC3A123A21" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H1I7</accession>
    <name>A0AAJ0H1I7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mob1/phocein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_25651</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725911.1">
        <property type="nucleotide sequence ID" value="XM_062863259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H1I7"/>
    <dbReference type="GeneID" id="87882088"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="17"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3310131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="346" mass="38186" checksum="1D14DE57BCB10E60" modified="2024-07-24" version="1">MSNLFSGINARFRGQRTPGSPGTSSPSPEQQAQPAAQSPVSPSHGSHPSSSSLAAKLPPLQSSPSLAETIGMDQSSGMMASAEDILTSYHLPPVKPLWLNANYAKHIVKGNFLTLSAKPKTVEMGEWIAHQVVDHWRMLITFIRLVHDKEEDGSSICNSRRCPKMSAGANHSFTWLNSRLQPVEIPAYEYLTLVQRYISGKIDDVNIFPTDLAGVSYADNPAFCTPLPESGQDWVGKRSGFPQNFMETCQTIFRQMFRVYAHLYWSHFDDMFSLNLEKSMNSCFSHFILTATTLNLLKKSDLEPMQPLIDLWAALGTFPQGSKAFEIANLQVGQLLVQKAGGPPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H1J6</accession>
    <name>A0AAJ0H1J6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein L35A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_570766</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725926.1">
        <property type="nucleotide sequence ID" value="XM_062870844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H1J6"/>
    <dbReference type="GeneID" id="87889673"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.190:FF:000001">
        <property type="entry name" value="60S ribosomal protein L35a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.190">
        <property type="entry name" value="translation elongation factor selb, chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00573">
        <property type="entry name" value="Ribosomal_eL33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001780">
        <property type="entry name" value="Ribosomal_eL33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018266">
        <property type="entry name" value="Ribosomal_eL33_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038661">
        <property type="entry name" value="Ribosomal_eL33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10902">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01247">
        <property type="entry name" value="Ribosomal_L35Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01105">
        <property type="entry name" value="RIBOSOMAL_L35AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3310146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="109" mass="12276" checksum="957EFFF4D65FC984" modified="2024-07-24" version="1">MPTEAGHRLYVKGRHLSYQRGRHNTHPRTSLIKIEGVDDTAAANFYLGKRVAYVYRGQKEVRGTKIRVIWGKVTRPHGNSGVVRAKFTNPLPARSFGASVRIMLYPSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H1T5</accession>
    <name>A0AAJ0H1T5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FYVE zinc finger-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_27170</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
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                <person name="Barry K."/>
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                <person name="Debuchy R."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
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                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
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                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
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                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Haridas S."/>
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                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
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                <person name="Clum A."/>
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                <person name="Ohm R."/>
                <person name="Martin F."/>
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                <person name="Natvig D."/>
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                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
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                <person name="Debuchy R."/>
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                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Thymopoietin"/>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="3">Uncharacterized protein</fullName>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726084.1">
        <property type="nucleotide sequence ID" value="XM_062864102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H2F4"/>
    <dbReference type="GeneID" id="87882931"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="232"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="352"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3310304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="450" mass="47818" checksum="939A152EAA592226" modified="2024-07-24" version="1">MLSNFKRSRLFARRPSLVPGRSLTTLQPCIGKGCRSLNVLPPVSVQRLLPPDNTRTTGSTKIIRLQDFRRFRSFEQWVVTHRTRGWARLEGCAAMDSTETAIDTTSRVCETQSGYIWYICTWKHPYYSGCCRVDPCKQDPIGCPIGWPASARGHPVATTDSASTSRPRTTSRTSPIRTTPGLTRTETAAASSSPSPSSTPTPGAGAGTTATISSTSTAVNANNSSSGITLSVGALVGIVVACAAVAVIAALSTCMWWWGRCRQRRDSIAPSLLVVSGPVKEPNPSALEPVFDSSVAHSMPRGVSDPASGMAPCSSQHHGNTQGTSNPSHWGPMVVVVKEDSMMSSPPARGLHLSNPSSDAHSSHASSLAPGNSWGVGVSLASSPSELGSAVVRREMEGGQATQSEAVEIDSRPIVNEAVESPRATLSSTQRERDTGTYANSWTRFQNLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H3F5</accession>
    <name>A0AAJ0H3F5_9PEZI</name>
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        <recommendedName>
            <fullName evidence="8">Protein Asterix</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_519614</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726624.1">
        <property type="nucleotide sequence ID" value="XM_062868443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H3F5"/>
    <dbReference type="GeneID" id="87887272"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045048">
        <property type="term" value="P:protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005351">
        <property type="entry name" value="ASTER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28038">
        <property type="entry name" value="ADL329WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28038:SF1">
        <property type="entry name" value="ADL329WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03669">
        <property type="entry name" value="ASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3310844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="117" mass="12679" checksum="5604CF4573D8AE2C" modified="2024-07-24" version="1">MESKKEKDMRQPDLIIPYQEPAAKGDSVEFQSTLSSTLPMAAIFMRNRYIGWAAVVFSIQSWLGESEETKKSTSTPGYFSVGMSLMSLVVTYLPIFLPPQPGMQQGSATGAPAPAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H3K2</accession>
    <name>A0AAJ0H3K2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_66398</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726983.1">
        <property type="nucleotide sequence ID" value="XM_062871170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H3K2"/>
    <dbReference type="GeneID" id="87889999"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040112">
        <property type="entry name" value="WetA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22934">
        <property type="entry name" value="PROTEIN ESC1/WETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22934:SF23">
        <property type="entry name" value="ZF-C3H1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="3">
        <location>
            <begin position="337"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="148"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="419"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="385"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3311203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="481" mass="52854" checksum="8DAD7A46A03161B2" modified="2024-07-24" version="1">MMDQQRATSQKFPAGLAGVLNSPEDNRDSAYYSSTDASSKHTSAASGMGVLSPPHSGFQPSPVDKTPSPTTTSHLLPHPLVSPTTTNSGNMSVASMVSPTPPATTDPRRIDRPQSLDSAPNNAGFVNGDIAEAMSRRESVDSRINQGFHDMRLGNSPYASHNQSTTSIHTTLQQQRNPRPGLDSLAPHRISNGYQPSAERNPEGHSKTMRIAPAITGPATSQIARAAEPTKGQAWAFPEEEIQRLPSATAQSLIDSRRSSIAESFASSQFTTESRLPAGQRRLEENMGGGGYQRLSNASGEYSTVHHHTLQHKQLGELRNEEAGAQTGTQPYSRTPELRISHKLAERKRRTEMKELFDQLRDLMPQERGSKASKWEILTKAISEHQRQSDLIRQLQALNQQQQNEIDMLRRELQERIHGAPTPRPADPYGPDQYARPRPPELPPLRSLQSATGPTGPDSMTGVQYEPPRVNGYRPGEPARF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H491</accession>
    <name>A0AAJ0H491_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sugar transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_388853</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727324.1">
        <property type="nucleotide sequence ID" value="XM_062864463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H491"/>
    <dbReference type="GeneID" id="87883292"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF83">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="363"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="432"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="13"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3311544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="500" mass="55339" checksum="F3E78862C4AD9559" modified="2024-07-24" version="1">MQALRENRRAVFWSIMISLSIIMEGYDTILIGNFFAYPEFAKKFGVDYGGTTGWQVPVAWQTGLNMSSTVGAIFGGLMNGYLASRFGYRWVMIGAMGLLNAFIFVVFFAPNAAALVGAQILCGLCWGVFATLSPAYASEVCPTNLRGYMTTYVNLCWAIGQLLASGVLRGCLPIAGAMGYKIPFAIQWVWPVPLMVIAYLAPESPWYLVRTDRLDEAKLSIARLSGEKTEEQISAQLAMMVHTTRLEAEVTKGATYLDCFRGVDLRRTEICMVAFMGQILSGSSFAYTPTYFFTTAGMETYNAFNLGLGAKGMAFLGTVLSWWLISYFGRRTLYVTGIGILTVVLFIIGILDVSAGTRGLWPSGGLCVFWLFTYSLTIGPLAYSIISETSSVRLRPLSVVLARTAYQITNIVSQVLYSYMQHPAAWNFKGKSGFFWGGTAFVVFVWAYFRLPEIKGRTYEELDILFANKTPARKFAEAHVDAYALSVPAEVREEKVKGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H4E6</accession>
    <name>A0AAJ0H4E6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_490217</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727399.1">
        <property type="nucleotide sequence ID" value="XM_062866662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H4E6"/>
    <dbReference type="GeneID" id="87885491"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.33.10:FF:000018">
        <property type="entry name" value="SCP-like extracellular protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002413">
        <property type="entry name" value="V5_allergen-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00838">
        <property type="entry name" value="V5ALLERGEN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042502824" evidence="2">
        <location>
            <begin position="18"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="3">
        <location>
            <begin position="150"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3311619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="321" mass="33603" checksum="8B811507386BDBAB" modified="2024-07-24" version="1">MKSTAFLALCGSVLATASPILQARKLYTKTDIVVEWVTVTVTEGDSSTVFQRPKAHHTATTITIVPAPSTTSVAPPPPPTTSSTSQAVVQPPPQPTPEPSPEPSPEPSTQAAPVVQSPPSVVQVAKVSTSAAPSPAPAKTSSASVAQPSDFQSTALYHHNVHRFNHSAGALEWSDEHAQYAETLAKTCVFEHNTKIGGGGYGQNLAMWGSTADPEAVGATESVARAASNGWYNGEINLFPSSEYGKATPDMTHFEDWGHFSQLVWKGTKKVGCASVFCQPGTLSSMGSWYTVCNYYPAGNVGGAYGDNVEPPQGQSTVTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H4G0</accession>
    <name>A0AAJ0H4G0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleoporin NUP53</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_409152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727164.1">
        <property type="nucleotide sequence ID" value="XM_062865348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H4G0"/>
    <dbReference type="GeneID" id="87884177"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3311384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="425" mass="47345" checksum="25553CC6FABDA154" modified="2024-07-24" version="1">MAPYILHNVPDEELYVGDDGIQRPYAVVFPQQDGSLRSRKMTHETGSFGKSTRRTRSKTATPAKREDPTIAAADKVFSSWIASQNQTQNTAQTITPATQRRPNLIPSTSTQNLSQAHEEIAAASQTRFNKQQAPTEVILRGYRSSQQQYAALNHYEQLAGRICEDYPREPPVENRRYKSDLRDPAFTRRRPLTPEERAKVNRADSGEHWVKVTFESAEAADAAIFASPQKILGHLVYAEPYHGIPPSRDEAVPDPATMATGLRRTSSLRRHSRTQSAAGMQHPGSADLSPPHSQLSSTLTADTMAMDSPTASSGTVTAGDGNGAAPTTQEHRDDEFCRVIPTVRKAKLLPMEQALLPAPSFSQRIMNHIPFLRWFSGAMIGSEVPRTETGEFDWNKASLYWKLMWWLDFLLGLFGGEIRDVDKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H4P7</accession>
    <name>A0AAJ0H4P7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endoplasmic reticulum junction formation protein lunapark</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_388499</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in determining ER morphology.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the lunapark family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727314.1">
        <property type="nucleotide sequence ID" value="XM_062864449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H4P7"/>
    <dbReference type="GeneID" id="87883278"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098826">
        <property type="term" value="C:endoplasmic reticulum tubular network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071788">
        <property type="term" value="P:endoplasmic reticulum tubular network maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903373">
        <property type="term" value="P:positive regulation of endoplasmic reticulum tubular network organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040115">
        <property type="entry name" value="Lnp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019273">
        <property type="entry name" value="Lunapark_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22166">
        <property type="entry name" value="ENDOPLASMIC RETICULUM JUNCTION FORMATION PROTEIN LUNAPARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22166:SF12">
        <property type="entry name" value="ENDOPLASMIC RETICULUM JUNCTION FORMATION PROTEIN LUNAPARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10058">
        <property type="entry name" value="Zn_ribbon_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Lunapark zinc ribbon" evidence="3">
        <location>
            <begin position="257"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="141"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="328"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="351"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3311534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="366" mass="40461" checksum="A46948D468233A67" modified="2024-07-24" version="1">MVSFWPWGKDSTSPASFERALSALSAKITTTQTQLDQTRTKSRRIKLLCMLYLGFAYLVYAIVLVLVVGWRNMGPWEWTGMAGGPVVISLVRAITTVFFDYRIERLSARLKEHQTERAKTIQKLKEATKYDSTLELLEKYGGTDNKQKRGNKTLEKEDAAAAEREEDRPKGKHLGLPQRTNMPPPPTANIPRPPIPGPVTPQSRPHSRLGTPFQPPPVQGGMDPSAEFAPNAFDERTPPAFMQYPPAAMAPQAESHWYDRILDTLLGEDETAPKNRIVLICSKCRLVNGQAPPGTRSLSELGMWKCMACGATNGEMDEGKRLVQEVLGGRSARKSESTDDNASRSSSDLVEVGKDIPEAELKGQLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LYI5</accession>
    <name>A0AAJ0LYI5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0T15DRAFT_403911</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718196.1">
        <property type="nucleotide sequence ID" value="XM_062865231.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87884060"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000102">
        <property type="entry name" value="ABC multidrug transporter Mdr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000009">
        <property type="entry name" value="ABC transporter B family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000251">
        <property type="entry name" value="ABC transporter B family member 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000302">
        <property type="entry name" value="ATP-binding cassette subfamily B member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF27">
        <property type="entry name" value="ATP-DEPENDENT TRANSLOCASE ABCB1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="363"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="769"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="814"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="895"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="919"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1001"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1033"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="100"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="427"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="771"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="1097"/>
            <end position="1334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="702"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3302416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1341" mass="146838" checksum="468EBE70B7A5002F" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LYL0</accession>
    <name>A0AAJ0LYL0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1770-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_543077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718271.1">
        <property type="nucleotide sequence ID" value="XM_062869959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LYL0"/>
    <dbReference type="GeneID" id="87888788"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140580">
        <property type="term" value="F:mitochondrion autophagosome adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013898">
        <property type="entry name" value="Atg43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38699">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38699:SF1">
        <property type="entry name" value="MITOPHAGY RECEPTOR ATG43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08589">
        <property type="entry name" value="ATG43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3302491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="177" mass="20687" checksum="967D7E2980B0B2FE" modified="2024-07-24" version="1">MASSLPLQVAETVQTAHLQRDPSPQHDLNPSTATSKKEPVRLEPVFPDDGGIDDVTEGTEGEEEEEDEFYRSRITPRPRRHNLPPMPDLRFEQSYLWSIRNADTWWKVGWITVRDQVMMPLVQGILYNLAICGWQYWNRNAQIHGSSIGARVRRWWYGVNNWPIPPERKVGVRRRAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LYP0</accession>
    <name>A0AAJ0LYP0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">V-type proton ATPase proteolipid subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0T15DRAFT_543016</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10 11">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Vacuole membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718243.1">
        <property type="nucleotide sequence ID" value="XM_062869954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LYP0"/>
    <dbReference type="GeneID" id="87888783"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18175">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18176">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000001">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011555">
        <property type="entry name" value="ATPase_proteolipid_su_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01100">
        <property type="entry name" value="V_ATP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <keyword evidence="11" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="128"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="19"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="95"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3302463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="167" mass="17264" checksum="3F539962D5D53627" modified="2024-07-24" version="1">MDIISLDRCPVYASFFGALGCACAIVFTVIGASYGTAKSAGAIFSSGIIRPDKLMQNTLCAIMAQIISIYGLVAAVIISNNLVEKMALHTGFLQLGAGLAVGLCGLAAGFAIGIVGDAGVRASTQQPRLYVGMVLILIFAEVLGLYGVIVSILMLSKSTLGVTECFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LYQ3</accession>
    <name>A0AAJ0LYQ3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_310521</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718364.1">
        <property type="nucleotide sequence ID" value="XM_062863920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LYQ3"/>
    <dbReference type="GeneID" id="87882749"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216:SF65">
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        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
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        </location>
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        </location>
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        <source>
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        </source>
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</entry>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
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                <person name="Hiltunen Thoren M."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
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        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR37919">
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Brannstrom I.O."/>
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                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
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                <person name="Kuo A."/>
                <person name="Mondo S."/>
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                <person name="LaButti K."/>
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                <person name="Grigoriev I.V."/>
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                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
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                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
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                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <location>
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        </location>
    </feature>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3302870.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="379" mass="41718" checksum="8B9D49D6288AF21D" modified="2024-07-24" version="1">MPTPPRTMSPQPLTWTPPADPDKPACPYRAGFTVNINTHVPPAPFGCRSYGTGTRTTVAGQPLRSLTQTELVLANPPLGTLDPPNPLSYTLSVTDVLAAGDGRGAQVVVCTVTPKVSASSASNPAPSPAPFQAVAKIYDPLYYSFRNRDVPSVPCDVTLLADQDYSCEAAAYEHLKAIGQAGAFAPRYYGSFTFTARVMVNKTTPRLRQVRLILIEHIQGPSIRDLCRAPRPAAPAPAAAFSEAFRLEVLARVMEGDAKLRWLGIMQRDVAGRNVLLQWPPGLQTAAQRTTLPRVVLIDYNVSVVYARTIRKIGPYDGMKLPPNPMELYWTNALQEFWGWIPVEWETNPKLRQQWLSKRFGGKNMTSFAPLTEKLEFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZI3</accession>
    <name>A0AAJ0LZI3_9PEZI</name>
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        <recommendedName>
            <fullName evidence="6 14 17">Homoserine dehydrogenase</fullName>
            <shortName evidence="14">HDH</shortName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">B0T15DRAFT_486869</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of L-aspartate-beta-semialdehyde (L-Asa) to L-homoserine (L-Hse), the third step in the biosynthesis of amino acids that derive from aspartate (the aspartate family of amino acids), including methioinine and threonine, the latter of which is a precursor to isoleucine; production of homoserine leads to a branch-point in the pathway as it can either be O-phosphorylated for processing to threonine, or O-acylated for processing to methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-homoserine + NADP(+) = L-aspartate 4-semialdehyde + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:15763"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:25213"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 17">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 14 18">Belongs to the homoserine dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.3" evidence="5 14 17"/>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719246.1">
        <property type="nucleotide sequence ID" value="XM_062866390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZI3"/>
    <dbReference type="GeneID" id="87885219"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004412">
        <property type="term" value="F:homoserine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009090">
        <property type="term" value="P:homoserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000006">
        <property type="entry name" value="Bifunctional aspartokinase/homoserine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005106">
        <property type="entry name" value="Asp/hSer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011147">
        <property type="entry name" value="Bifunc_Aspkin/hSer_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001342">
        <property type="entry name" value="HDH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019811">
        <property type="entry name" value="HDH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022697">
        <property type="entry name" value="HDH_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43070:SF5">
        <property type="entry name" value="HOMOSERINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00742">
        <property type="entry name" value="Homoserine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03447">
        <property type="entry name" value="NAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036497">
        <property type="entry name" value="HDH_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01042">
        <property type="entry name" value="HOMOSER_DHGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14 17" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 14 17" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="9 14 16" id="KW-0521">NADP</keyword>
    <keyword evidence="10 14 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14 17" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Aspartate/homoserine dehydrogenase NAD-binding" evidence="20">
        <location>
            <begin position="15"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Homoserine dehydrogenase catalytic" evidence="19">
        <location>
            <begin position="157"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="15"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>L-homoserine</name>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR036497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR036497-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR036497-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF03447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAK3303466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="367" mass="38922" checksum="6F14B35E2CE55D50" modified="2024-07-24" version="1">MASASVRQVNIAIIGAGGVGKCFLSQLEQLATRRPNPKLVLTYICTSKKALYSTDYIAVDIKNVTSSLASSPLAPLPLTKLADFLTSSGSKTVLVDNTSSQDVAEAYPLFLSRGISIVTPNKKAFSGSYKLWQDIFGAAEKSGAKVYHESSVGAGLPVISTLKDLVDTGDEVTKIEGVFSGTMSFLFNSFAPTSGSGGKWSAEVKKAKELGYTEPDPRDDLNGLDVARKLTILARLAGLPVESPTSFPVQSLIPKELETVASGDEFLEKLPVFDAQMEETKAEAEKEGKVVRFVGSIDVATKQVKVGLEKFDLSHPIAALKGSDNIISFYTKRYGSNPLIIQGAGAGGEVTAMGVTSDLLKVLSQIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZJ4</accession>
    <name>A0AAJ0LZJ4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_560497</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719235.1">
        <property type="nucleotide sequence ID" value="XM_062870532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZJ4"/>
    <dbReference type="GeneID" id="87889361"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035361">
        <property type="term" value="C:Cul8-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990683">
        <property type="term" value="P:DNA double-strand break attachment to nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00027">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18436">
        <property type="entry name" value="BRCT_BRC1_like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18437">
        <property type="entry name" value="BRCT_BRC1_like_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18438">
        <property type="entry name" value="BRCT_BRC1_like_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17743">
        <property type="entry name" value="BRCT_BRC1_like_rpt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18439">
        <property type="entry name" value="BRCT_BRC1_like_rpt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000048">
        <property type="entry name" value="DNA repair protein Rtt107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053036">
        <property type="entry name" value="CellCycle_DNARepair_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47667">
        <property type="entry name" value="REGULATOR OF TY1 TRANSPOSITION PROTEIN 107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47667:SF1">
        <property type="entry name" value="REGULATOR OF TY1 TRANSPOSITION PROTEIN 107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16770">
        <property type="entry name" value="RTT107_BRCT_5"/>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
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</entry>
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                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
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                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
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                <person name="Ng V."/>
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                <person name="Steindorff A."/>
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                <person name="Ament-Velasquez S.L."/>
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                <person name="Miller A.N."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
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                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Cros-Aarteil S."/>
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
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                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
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                <person name="Daum C."/>
                <person name="Ng V."/>
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                <person name="Steindorff A."/>
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                <person name="Grigoriev I.V."/>
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                <person name="Hiltunen Thoren M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
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                <person name="Brannstrom I.O."/>
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
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                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3303947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719727.1">
        <property type="nucleotide sequence ID" value="XM_062869478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZZ6"/>
    <dbReference type="GeneID" id="87888307"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    </feature>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    <sequence length="192" mass="20976" checksum="D183E5A01DBC3345" modified="2024-07-24" version="1">MAGLSPQVTNLIIILGMMQVAKKIPFDDPQVLNLCRAAYITSNLIILGIYMYIKVVIDKKKDMTTLKYVEPAPMGSSEEGKLVTTTVHAYDVGQLKQLMRGQGMGVLMMAVMHLYFKYTNPLLIQSIIPLKSALESNLTKIHLWGQPAVGDLKRPFKQAAGLMSGLQSGPAQADKKAVESAERAGRGGVKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M040</accession>
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        <recommendedName>
            <fullName evidence="4">SSCRP protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_228872</name>
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    <organism evidence="2 3">
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        <lineage>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719846.1">
        <property type="nucleotide sequence ID" value="XM_062862915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M040"/>
    <dbReference type="GeneID" id="87881744"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042559368" description="SSCRP protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3304066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="101" mass="10635" checksum="ADD54F7BDC1017E0" modified="2024-07-24" version="1">MKTFASILLGLVAAVSAEDYVYYTGNRCTGDVVGSGTLACGPNPMPLSPLIHGIRLNFANGLRTRFHDNRDCSGAAWFTDDGTGGCVTDSAARTNCIFVPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M045</accession>
    <name>A0AAJ0M045_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mannosyltransferase putative-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0T15DRAFT_512280</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MNN1/MNT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719861.1">
        <property type="nucleotide sequence ID" value="XM_062867969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M045"/>
    <dbReference type="GeneID" id="87886798"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046354">
        <property type="term" value="P:mannan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646:SF1">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="12">
        <location>
            <begin position="772"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="426"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="571"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="622"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="426"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="440"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="629"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="651"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="699"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="748"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3304081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="847" mass="95918" checksum="F89FCA82B336493A" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M0N4</accession>
    <name>A0AAJ0M0N4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SANT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_400041</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720432.1">
        <property type="nucleotide sequence ID" value="XM_062865038.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87883867"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051571">
        <property type="entry name" value="N-CoR_corepressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13992">
        <property type="entry name" value="NUCLEAR RECEPTOR CO-REPRESSOR RELATED NCOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13992:SF39">
        <property type="entry name" value="SMRTER, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
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        </location>
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        </location>
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        </location>
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        </location>
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    </evidence>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
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                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
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                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
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                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
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                <person name="Labutti K."/>
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                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
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                <person name="Natvig D."/>
                <person name="Lalanne C."/>
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                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </location>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M0S5</accession>
    <name>A0AAJ0M0S5_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">B0T15DRAFT_537509</name>
    </gene>
    <organism evidence="2 3">
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Grigoriev I.V."/>
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                <person name="Hiltunen Thoren M."/>
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            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
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                <person name="Chen C."/>
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                <person name="Martin F."/>
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                <person name="Natvig D."/>
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                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720539.1">
        <property type="nucleotide sequence ID" value="XM_062869622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M0S5"/>
    <dbReference type="GeneID" id="87888451"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3304759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="102" mass="11400" checksum="7652BE722E04DCC1" modified="2024-07-24" version="1">MRILCCTWQMWRCANAQQHVWGPWDHTRPQNPSWLSLQVGRVTKRQGTGDRVILGRGSKVHKRRRVGGTSGGSGSGLLDGARTCGKCRMPGDRRVASMFDVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M126</accession>
    <name>A0AAJ0M126_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_188479</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat HIR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720870.1">
        <property type="nucleotide sequence ID" value="XM_062862414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M126"/>
    <dbReference type="GeneID" id="87881243"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055410">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24105">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NACHT" evidence="8">
        <location>
            <begin position="201"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="752"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="794"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="836"/>
            <end position="877"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3305090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="970" mass="106992" checksum="660062D5388A793D" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M1K2</accession>
    <name>A0AAJ0M1K2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Adenine DNA glycosylase</fullName>
            <ecNumber evidence="3 13">3.2.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0T15DRAFT_485192</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Adenine glycosylase active on G-A mispairs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Hydrolyzes free adenine bases from 7,8-dihydro-8-oxoguanine:adenine mismatched double-stranded DNA, leaving an apurinic site.</text>
            <dbReference type="EC" id="3.2.2.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="13">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the Nth/MutY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.31" evidence="3 13"/>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721391.1">
        <property type="nucleotide sequence ID" value="XM_062866281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M1K2"/>
    <dbReference type="GeneID" id="87885110"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034039">
        <property type="term" value="F:8-oxo-7,8-dihydroguanine DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035485">
        <property type="term" value="F:adenine/guanine mispair binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032357">
        <property type="term" value="F:oxidized purine DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000701">
        <property type="term" value="F:purine-specific mismatch base pair DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03431">
        <property type="entry name" value="NUDIX_DNA_Glycosylase_C-MutY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000002">
        <property type="entry name" value="Adenine DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003651">
        <property type="entry name" value="Endonuclease3_FeS-loop_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044298">
        <property type="entry name" value="MIG/MutY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029119">
        <property type="entry name" value="MutY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42944">
        <property type="entry name" value="ADENINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42944:SF1">
        <property type="entry name" value="ADENINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14815">
        <property type="entry name" value="NUDIX_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00525">
        <property type="entry name" value="FES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="12 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="15">
        <location>
            <begin position="78"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3305611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="523" mass="57832" checksum="69465C14457ED3FF" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M1Q6</accession>
    <name>A0AAJ0M1Q6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RecQ mediated genome instability protein 1-like N-terminal helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_434947</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721556.1">
        <property type="nucleotide sequence ID" value="XM_062865806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M1Q6"/>
    <dbReference type="GeneID" id="87884635"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.770">
        <property type="entry name" value="RecQ-mediated genome instability protein Rmi1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049363">
        <property type="entry name" value="RMI1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042470">
        <property type="entry name" value="RMI1_N_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013894">
        <property type="entry name" value="RMI1_OB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08585">
        <property type="entry name" value="RMI1_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21000">
        <property type="entry name" value="RMI1_N_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RMI1 N-terminal" evidence="3">
        <location>
            <begin position="11"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="RecQ mediated genome instability protein 1 OB-fold" evidence="2">
        <location>
            <begin position="79"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3305776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="258" mass="27487" checksum="586C01D80F137A72" modified="2024-07-24" version="1">MDIATQLQTSLRSTSNPVPSLTWLQTLATARSPAPPLASLLATARTRLLASDLTTPGLLDTEYMAAHSLAPNTAQTLATSRETRLGREVVVQVLDIEDVSRSRWEEVERLEAVARGEGTRGREVIRVMNSSSSAGGDGNGGGEDGDETGPGDGGGGQQQQQREAGPPRNVTHKLVVQDCKGQKVHAIELKRVDKLGVGTTLIGEKVLLRAGTVVARGVVLLDPAQCVVLGGKVEAWHRAWVDGRLARLREAVGAERRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M213</accession>
    <name>A0AAJ0M213_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SRR1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_218974</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3306136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721916.1">
        <property type="nucleotide sequence ID" value="XM_062862785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M213"/>
    <dbReference type="GeneID" id="87881614"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012942">
        <property type="entry name" value="SRR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42080">
        <property type="entry name" value="SRR1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42080:SF1">
        <property type="entry name" value="SRR1-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07985">
        <property type="entry name" value="SRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="SRR1-like" evidence="2">
        <location>
            <begin position="108"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3306136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="284" mass="31630" checksum="434A751F690A94BB" modified="2024-07-24" version="1">MRTGAPIFRLMMNGDFAPDVITSAPRLVNRCGPFARFHNPPNLEELLQTRALNKIEMVIFIYDFRYAQLHADNADKGIANFDAIVQERWMNSPARRSLYFTLSHYAIGPVTTILGFGLGSFMQRYPHRHGRTVAGATNNTNTEKVQHGLLLDVRDTLQAKSSGQISILAQDPESRELDQAVLRHKGIDSTVHPLEGFIKADNQSFVVSIDPDVPAKKLSLISVGRPQFYGWIALAHSIRNRPKWTGFSTTNICPSPWSKQTGLLCGHTPLMAGWSSISAKKDGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M235</accession>
    <name>A0AAJ0M235_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_398195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAK3306152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062864941.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87883770"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="1"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="745"/>
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    </feature>
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            <begin position="76"/>
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    </feature>
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            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="323"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="565"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="599"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="613"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3306152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="797" mass="85051" checksum="70DAED77EDB41C42" modified="2024-07-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M288</accession>
    <name>A0AAJ0M288_9PEZI</name>
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        <submittedName>
            <fullName evidence="4">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">B0T15DRAFT_552164</name>
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        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722175.1">
        <property type="nucleotide sequence ID" value="XM_062870289.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87889118"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056599">
        <property type="entry name" value="AAA_lid_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF3">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA_lid_13"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="152"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase lid" evidence="3">
        <location>
            <begin position="262"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="488"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="583"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="595"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3306395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M2R8</accession>
    <name>A0AAJ0M2R8_9PEZI</name>
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        <recommendedName>
            <fullName evidence="8">Ribonuclease P/MRP protein subunit POP5</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_395811</name>
    </gene>
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        <name type="scientific">Chaetomium strumarium</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP, which cleaves pre-rRNA sequences.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic/archaeal RNase P protein component 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="4"/>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722652.1">
        <property type="nucleotide sequence ID" value="XM_062864800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M2R8"/>
    <dbReference type="GeneID" id="87883629"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030681">
        <property type="term" value="C:multimeric ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033204">
        <property type="term" value="F:ribonuclease P RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease P/MRP protein subunit POP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3250">
        <property type="entry name" value="Ribonuclease P, Pop5 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002759">
        <property type="entry name" value="Pop5/Rpp14/Rnp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038085">
        <property type="entry name" value="Rnp2-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15441">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15441:SF2">
        <property type="entry name" value="RIBONUCLEASE P_MRP PROTEIN SUBUNIT POP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01900">
        <property type="entry name" value="RNase_P_Rpp14"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rnp2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000928"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044198"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00055200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3306872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="191" mass="20800" checksum="D952B56A07A97F2E" modified="2024-07-24" version="1">MVRLKDRYLLVNIIYSDVPPGQAKGAVPDLLLYNQPTSSELRPQHLLKAIRSEVSALFGDCGLGAIDKSLQAVKYLSPATSTLILRVSRAHYRLVWAALSFMDRVPVRDGRPCAFRVVRVSGTIRKVEEEAVRRAKLLVLAAKDEMAGKSSSNALGALLRSDNQVRSFAVLDAPNPPVSEAGDDVIMSDDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M313</accession>
    <name>A0AAJ0M313_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_393841</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAK3306889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722669.1">
        <property type="nucleotide sequence ID" value="XM_062864707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M313"/>
    <dbReference type="GeneID" id="87883536"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027040">
        <property type="entry name" value="PSMD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223:SF2">
        <property type="entry name" value="F-BOX AND WD DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G11400)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="129"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="974"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1052"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1085"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1152"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="990"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1060"/>
            <end position="1069"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3306889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1175" mass="126193" checksum="B5EE373DC24B48F8" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M3P5</accession>
    <name>A0AAJ0M3P5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_508375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
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                <person name="Steindorff A."/>
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                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
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                <person name="Hutchinson M.I."/>
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                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </evidence>
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        <source>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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            <strain evidence="3">CBS 333.67</strain>
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    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Bonometti L."/>
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                <person name="Labutti K."/>
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                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
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                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
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<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Cros-Aarteil S."/>
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
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                <person name="Ament-Velasquez S.L."/>
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                <person name="Grigoriev I.V."/>
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                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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            <dbReference type="PubMed" id="37820761"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 3">Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>cyanate + hydrogencarbonate + 3 H(+) = NH4(+) + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:11120"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29195"/>
            <dbReference type="EC" id="4.2.1.104"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cyanase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.104" evidence="3"/>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M4T6"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008824">
        <property type="term" value="F:cyanate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00559">
        <property type="entry name" value="Cyanase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1160.10">
        <property type="entry name" value="Cyanate lyase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00535">
        <property type="entry name" value="Cyanate_hydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008076">
        <property type="entry name" value="Cyanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003712">
        <property type="entry name" value="Cyanate_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036581">
        <property type="entry name" value="Cyanate_lyase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048564">
        <property type="entry name" value="CYNS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00673">
        <property type="entry name" value="cynS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34186">
        <property type="entry name" value="CYANATE HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34186:SF2">
        <property type="entry name" value="CYANATE HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02560">
        <property type="entry name" value="Cyanate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21291">
        <property type="entry name" value="CYNS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001263">
        <property type="entry name" value="Cyanate_hydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01693">
        <property type="entry name" value="CYANASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01116">
        <property type="entry name" value="Cyanate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55234">
        <property type="entry name" value="Cyanase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyanate lyase C-terminal" evidence="4">
        <location>
            <begin position="105"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3308869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="178" mass="19739" checksum="F2ED353998F1099A" modified="2024-07-24" version="1">MSAPERRSSVMAIAEQQPRLASLDSSIVDRLPSYSATLFEAKSQKRLTFEQIAEHLGRSEVAVAALFYGQAQASPEDAAKLTKLLGLSQESNIASQMMGFPDRGRAGPMPPVEPLIYRLYEIVQNYGYAYKAVLNEKFGDGIMSAICFNSKVEKEVDENGAPWVVITLKGKWLPFTRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M543</accession>
    <name>A0AAJ0M543_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Poly [ADP-ribose] polymerase</fullName>
            <shortName evidence="15">PARP</shortName>
            <ecNumber evidence="15">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">B0T15DRAFT_566078</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>NAD(+) + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H(+).</text>
            <dbReference type="EC" id="2.4.2.30"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the ARTD/PARP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.-" evidence="15"/>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3309199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724979.1">
        <property type="nucleotide sequence ID" value="XM_062870686.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87889515"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990404">
        <property type="term" value="F:NAD+-protein mono-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070212">
        <property type="term" value="P:protein poly-ADP-ribosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17747">
        <property type="entry name" value="BRCT_PARP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd01437">
        <property type="entry name" value="parp_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07997">
        <property type="entry name" value="WGR_PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.142.10:FF:000002">
        <property type="entry name" value="Poly [ADP-ribose] polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.140.10:FF:000001">
        <property type="entry name" value="Poly [ADP-ribose] polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.228.10:FF:000002">
        <property type="entry name" value="Poly [ADP-ribose] polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.142.10">
        <property type="entry name" value="Poly(ADP-ribose) polymerase, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.140.10">
        <property type="entry name" value="WGR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050800">
        <property type="entry name" value="ARTD/PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004102">
        <property type="entry name" value="Poly(ADP-ribose)pol_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036616">
        <property type="entry name" value="Poly(ADP-ribose)pol_reg_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036930">
        <property type="entry name" value="WGR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008893">
        <property type="entry name" value="WGR_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10459">
        <property type="entry name" value="DNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10459:SF60">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02877">
        <property type="entry name" value="PARP_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05406">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00773">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47587">
        <property type="entry name" value="Domain of poly(ADP-ribose) polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142921">
        <property type="entry name" value="WGR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51060">
        <property type="entry name" value="PARP_ALPHA_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51977">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0013">ADP-ribosylation</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 15" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 15" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BRCT" evidence="18">
        <location>
            <begin position="14"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="WGR" evidence="21">
        <location>
            <begin position="223"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="PARP alpha-helical" evidence="20">
        <location>
            <begin position="351"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="PARP catalytic" evidence="19">
        <location>
            <begin position="486"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="17">
        <location>
            <begin position="739"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="17">
        <location>
            <begin position="797"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="104"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="326"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="837"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="109"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="326"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="340"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="870"/>
            <end position="879"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAK3309199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1446" mass="157927" checksum="7760BFC02FBF4D28" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M563</accession>
    <name>A0AAJ0M563_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_134453</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3309230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725010.1">
        <property type="nucleotide sequence ID" value="XM_062861793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M563"/>
    <dbReference type="GeneID" id="87880622"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000149">
        <property type="entry name" value="MFS transporter, SP family, general alpha glucoside:H+ symporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF56">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="57"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="415"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="450"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="480"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="60"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3309230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="563" mass="63239" checksum="039A94B2FD06FC72" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M583</accession>
    <name>A0AAJ0M583_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">C2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0T15DRAFT_570296</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725323.1">
        <property type="nucleotide sequence ID" value="XM_062870831.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87889660"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04044">
        <property type="entry name" value="C2A_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04052">
        <property type="entry name" value="C2B_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04045">
        <property type="entry name" value="C2C_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04040">
        <property type="entry name" value="C2D_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21678">
        <property type="entry name" value="SMP_TCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="C2_dom"/>
    </dbReference>
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        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037761">
        <property type="entry name" value="C2A_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037765">
        <property type="entry name" value="C2B_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037762">
        <property type="entry name" value="C2C_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037756">
        <property type="entry name" value="C2D_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056910">
        <property type="entry name" value="TCB1-3_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017147">
        <property type="entry name" value="Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052455">
        <property type="entry name" value="Tricalbin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46980">
        <property type="entry name" value="TRICALBIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46980:SF2">
        <property type="entry name" value="TRICALBIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24920">
        <property type="entry name" value="C2_TCB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25669">
        <property type="entry name" value="SMP_MUG190-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037232">
        <property type="entry name" value="Tricalbin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="181"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="14">
        <location>
            <begin position="234"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="435"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="578"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="715"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="1085"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="1324"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="870"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1275"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1452"/>
            <end position="1497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="877"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="899"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="928"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1484"/>
            <end position="1497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3309543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1497" mass="165725" checksum="926349931B6F91C2" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M5K1</accession>
    <name>A0AAJ0M5K1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_488619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062866527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M5K1"/>
    <dbReference type="GeneID" id="87885356"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF6">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3309918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="359" mass="38753" checksum="62C03D38F63F6903" modified="2024-07-24" version="1">MAPRVVVTGVTGYIGGDAFHALYEAHPDFDYTLLVRTKERAESVRGQYGNVDKVKVLYPGEVGPSVSFTEVLEDQAKKADVVLHTADSADDVAQATAILRGLQAAGRSAENPAYWIHISGTGILTWYDHAQSRYGQAPVPEQAYNDLTGIDRLVNLPDQAPHRNVDNIVLSANDNPGIKTAIVAPPTIYGAGRGPVNKSSIALPLLTRFILKHGYAPVIGEGRNEWDNVHVSDVSSLLVRLVDAALDPARKRNPEEIFGGRAYYFCASGTHACGKVAVDIAEEAVRQGLLKEALPKVVSLGEREITDEVGAMWAANSKGVAERARRYLGWEARGPSLEEEIPRVVELEGKKAGVEGKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M5S2</accession>
    <name>A0AAJ0M5S2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0T15DRAFT_18617</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="3"/>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725714.1">
        <property type="nucleotide sequence ID" value="XM_062862379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M5S2"/>
    <dbReference type="GeneID" id="87881208"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06602">
        <property type="entry name" value="GH31_MGAM_SI_GAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1760:FF:000005">
        <property type="entry name" value="Putative alpha-glucosidase AgdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000138">
        <property type="entry name" value="Putative alpha-glucosidase AgdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030458">
        <property type="entry name" value="Glyco_hydro_31_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030459">
        <property type="entry name" value="Glyco_hydro_31_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF133">
        <property type="entry name" value="P-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00129">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00707">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="10">
        <location>
            <begin position="523"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="11">
        <location>
            <begin position="959"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="738"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="738"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3309934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1187" mass="130145" checksum="D0B526840AD84AD9" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M5X4</accession>
    <name>A0AAJ0M5X4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SRF-type transcription factor (DNA-binding and dimerization domain)-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_31771</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726058.1">
        <property type="nucleotide sequence ID" value="XM_062864019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M5X4"/>
    <dbReference type="GeneID" id="87882848"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00266">
        <property type="entry name" value="MADS_SRF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1810.10:FF:000002">
        <property type="entry name" value="Serum response factor b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050142">
        <property type="entry name" value="MADS-box/MEF2_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033897">
        <property type="entry name" value="SRF-like_MADS-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48019">
        <property type="entry name" value="SERUM RESPONSE FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00350">
        <property type="entry name" value="MADS_BOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="7">
        <location>
            <begin position="54"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="136"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="138"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="190"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3310278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="218" mass="23654" checksum="97F599BDEB53CD5A" modified="2024-07-24" version="1">MADITDQHDQTSPTELDDAHSVSNGNAAVESRGIKRARPSTADDDDDDDEKGGRERRKIEIKFISDKSRRHITFSKRKAGIMKKAYELSVLTGTQVLLLVVSETGLVYTFTTPKLQPLVTKAEGKNLIQACLNAPEPAAGDGVDDASAVDSPEEPTSAHLPPQPSRPGLPQGHMPPSYMPNVGMDPQQALAYSSYVQQSRPNQYMPPASLQQHAGHQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M6F5</accession>
    <name>A0AAJ0M6F5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hsp70 protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_408125</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726611.1">
        <property type="nucleotide sequence ID" value="XM_062865334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M6F5"/>
    <dbReference type="GeneID" id="87884163"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10232">
        <property type="entry name" value="ASKHA_NBD_HSP70_ScSsz1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000009">
        <property type="entry name" value="Heat shock protein Hsp70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000023">
        <property type="entry name" value="Hsp70 chaperone (BiP)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF32">
        <property type="entry name" value="HEAT SHOCK PROTEIN PDR13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="477"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="482"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="501"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3310831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="580" mass="62302" checksum="74E0E5315DFF6588" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M6K7</accession>
    <name>A0AAJ0M6K7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Exosome complex protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_571267</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for exosome-dependent processing of pre-rRNA and small nucleolar RNA (snRNA) precursors. Involved in processing of 35S pre-rRNA at the A0, A1 and A2 sites.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the C1D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726540.1">
        <property type="nucleotide sequence ID" value="XM_062870852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M6K7"/>
    <dbReference type="GeneID" id="87889681"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011082">
        <property type="entry name" value="Exosome-assoc_fac/DNA_repair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007146">
        <property type="entry name" value="Sas10/Utp3/C1D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15341:SF3">
        <property type="entry name" value="NUCLEAR NUCLEIC ACID-BINDING PROTEIN C1D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15341">
        <property type="entry name" value="SUN-COR STEROID HORMONE RECEPTOR CO-REPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04000">
        <property type="entry name" value="Sas10_Utp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="132"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="132"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="162"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3310760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="176" mass="19652" checksum="8D1BA9E5FE1E3EDA" modified="2024-07-24" version="1">MDVTDVTPQLDRLEEELNKAEEVLNPLLGDIGDISSKLPLLDKAKLYVLATYTIESLLFSALRLNGVDTRNHAVFTELTRVKQYTEKIQKLENPPAPRENMVNTEAAARLLKSDLGDNKDIKAKLTELIAKEREKAGAKSTEKKRPAEESAVENSSTDAGQKLRKRPKRNGGKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M6W1</accession>
    <name>A0AAJ0M6W1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Dipeptidyl peptidase 3</fullName>
            <ecNumber evidence="4 15">3.4.14.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 15">Dipeptidyl aminopeptidase III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14 15">Dipeptidyl peptidase III</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B0T15DRAFT_520963</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Release of an N-terminal dipeptide from a peptide comprising four or more residues, with broad specificity. Also acts on dipeptidyl 2-naphthylamides.</text>
            <dbReference type="EC" id="3.4.14.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 17">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15 17">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase M49 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.4" evidence="4 15"/>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727061.1">
        <property type="nucleotide sequence ID" value="XM_062868535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M6W1"/>
    <dbReference type="GeneID" id="87887364"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.30:FF:000001">
        <property type="entry name" value="Dipeptidyl peptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.30:FF:000002">
        <property type="entry name" value="Dipeptidyl peptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.30:FF:000004">
        <property type="entry name" value="Dipeptidyl peptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005317">
        <property type="entry name" value="Dipeptidyl-peptase3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039461">
        <property type="entry name" value="Peptidase_M49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422:SF11">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE III-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03571">
        <property type="entry name" value="Peptidase_M49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007828">
        <property type="entry name" value="Dipeptidyl-peptidase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="7 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 15 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15 17" id="KW-0862">Zinc</keyword>
    <feature type="active site" evidence="16">
        <location>
            <position position="495"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="494"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="499"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="553"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR007828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR007828-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR007828-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK3311281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="754" mass="83889" checksum="03D90EC3FF68CBA1" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M771</accession>
    <name>A0AAJ0M771_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_507940</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727152.1">
        <property type="nucleotide sequence ID" value="XM_062867682.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87886511"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF16">
        <property type="entry name" value="ATP-DEPENDENT HELICASE ULS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="1251"/>
            <end position="1401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="597"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="833"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1173"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1533"/>
            <end position="1679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="845"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1183"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1547"/>
            <end position="1559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1652"/>
            <end position="1663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1669"/>
            <end position="1679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3311372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1679" mass="186797" checksum="96297D05822A8E2C" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GKG7</accession>
    <name>A0AAJ0GKG7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal recognition particle 9 kDa protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_317160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717379.1">
        <property type="nucleotide sequence ID" value="XM_062864010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GKG7"/>
    <dbReference type="GeneID" id="87882839"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039914">
        <property type="entry name" value="SRP9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039432">
        <property type="entry name" value="SRP9_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12834">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 9 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12834:SF12">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 9 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05486">
        <property type="entry name" value="SRP9-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP9" evidence="2">
        <location>
            <begin position="6"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3301599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="189" mass="19085" checksum="DA263312E146DD3C" modified="2024-07-24" version="1">MPYYGKSEDWLHQSALLLQARPATTRITTRYHIKPARRMPKSAKAEEAGAAANPPQPEETAQQQQQEEEKPPRGHLVLKTYDPASGVTLKYKTSKAAEVTRLVQMLGTLGRRMAGVAVETTPAATSGGGAGGDEVVMGEAPPVGGGESEAAAAGGGGSGAQTPTPAAGAGSGAGAGGGGGKGKKKKGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GKS7</accession>
    <name>A0AAJ0GKS7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_544453</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717503.1">
        <property type="nucleotide sequence ID" value="XM_062870077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GKS7"/>
    <dbReference type="GeneID" id="87888906"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF31">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN YCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="38"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3301723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="326" mass="35725" checksum="B27205762FD40A3B" modified="2024-07-24" version="1">MAIFHSKVDSASLFFRHYIPSSSPYKPASTVAHQPLTLVFLHGWPMSSRMYDQLIVPLVETHRFPVIAPDRRGFGNSEWTTPTTTAEGVTFDTFVADLISLLEHALLGNTNTNTNTNPSYSAPFVFVAASMGCSESVLARAASSFVRAHCKGFVWIGPNMPYSLRCDECPAAPDRAVWEGLIDGFRGAGGKDFIAQALPGVFRVDLGNEVGKRTLQFFERIVGQADPMALERTTTILQRPMVAELKRLADEEGGANKPDRIPVLILHGDSDSGMPLEASAAVVHEMLPWSELKVYEKAGHGLYLTHAQQVLDDLLAFLSPIVARLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GKY0</accession>
    <name>A0AAJ0GKY0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_563508</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717624.1">
        <property type="nucleotide sequence ID" value="XM_062870621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GKY0"/>
    <dbReference type="GeneID" id="87889450"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053187">
        <property type="entry name" value="Notoamide_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="31"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3301844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="615" mass="70207" checksum="C038C606B3E8832E" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GL36</accession>
    <name>A0AAJ0GL36_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_286852</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3301929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717709.1">
        <property type="nucleotide sequence ID" value="XM_062863651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GL36"/>
    <dbReference type="GeneID" id="87882480"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF27">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="199"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="73"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="864"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="928"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1029"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="1029"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1052"/>
            <end position="1062"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3301929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1126" mass="121298" checksum="1CE8AFB70DA28DB9" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GLA3</accession>
    <name>A0AAJ0GLA3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase family 16 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_289538</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717811.1">
        <property type="nucleotide sequence ID" value="XM_062863690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GLA3"/>
    <dbReference type="GeneID" id="87882519"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00413">
        <property type="entry name" value="Glyco_hydrolase_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38121">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38121:SF4">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042559036" evidence="1">
        <location>
            <begin position="31"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="2">
        <location>
            <begin position="64"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3302031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="398" mass="43848" checksum="F8EF57F5ED180173" modified="2024-07-24" version="1">MEQLKRTLCLPSSLSSLIFLISATIPAAAAADPALTDDSRCGCYLTNGNQSAFFADHRFFDFRSLSEDAGVPAVVQNVDASAGAEMTSAYFSSSEWTDFWMLGSWNNSNHGRSDATVLMVNSPNNIYIEANNEANPSSQTWLTLRTQRLADFQTAAEIESASAKFRYLSIRMRARTVGAAGAITAMFTYRDADTLAKVQESDLEIRTSDPRNLIHYTNQPAYTDAGDTVPQATQNATMPGGRDWTDWAVHRMDWTPGKTTWYVDDTQVAQIEFQAPRDESNLILNAWSDGGAWTGNMSRNDAAYLQVQWLEVVFNNTEVGKMTDKERRRRTGRRREDGGGSGCAAVCSIDQTPQLGKPVMLWDNRAAGNQPNGVGRLVSWLPMGMVSLMVLVSTGLLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GLC3</accession>
    <name>A0AAJ0GLC3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TMEM205-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_403975</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717829.1">
        <property type="nucleotide sequence ID" value="XM_062865233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GLC3"/>
    <dbReference type="GeneID" id="87884062"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025423">
        <property type="entry name" value="TMEM205-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053009">
        <property type="entry name" value="Xanthocillin_Biosynth-Assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23241:SF106">
        <property type="entry name" value="DUF4149 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23241">
        <property type="entry name" value="LATE EMBRYOGENESIS ABUNDANT PLANTS LEA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13664">
        <property type="entry name" value="DUF4149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="TMEM205-like" evidence="6">
        <location>
            <begin position="12"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3302049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="171" mass="18424" checksum="C4C914D7DF94FB83" modified="2024-07-24" version="1">MSLLSPAPYHVLSYGTLLGTTFFHTFVGGIVSFQVLPRPQFAALMAKIFPVYFTMQTALPAVMAITYPAGGVSGVLDPSNRWRVLAPIAGAFLCALGNLAVVGPATTRVMDERRQQEKKDGKKSYDAPPHSQEMVALNKQFSMLHGISSLLNLGTFVAAVVYGVSLSSRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GM44</accession>
    <name>A0AAJ0GM44_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_307269</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062863882.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87882711"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="ZNF511"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3302483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
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            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062868141.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87886970"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3302683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="143" mass="15828" checksum="0B2B8DB221327933" modified="2024-07-24" version="1">MSTEPRATVTVQPPRFVRKGSTILPPVQVRVQFDAGDPRLKQLEMIFATATLRYANTTTVETDPNRNQAAASPAEVCNDSPVGDTLNFIFQNLQLPDGLHGDCFYRITIDILHTTAMETTDNGDPKLEKLTIAHTDTRPFTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ0GMR7_9PEZI</name>
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            <fullName evidence="3">PIPK domain-containing protein</fullName>
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    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
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                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718385.1">
        <property type="nucleotide sequence ID" value="XM_062865914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GMR7"/>
    <dbReference type="GeneID" id="87884743"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016308">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
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    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023610">
        <property type="entry name" value="PInositol-4/5-P-5/4-kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086:SF126">
        <property type="entry name" value="PIPK DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIPK" evidence="3">
        <location>
            <begin position="1"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="270"/>
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    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3302605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GMS1</accession>
    <name>A0AAJ0GMS1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_258021</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
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    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3302856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718636.1">
        <property type="nucleotide sequence ID" value="XM_062863276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GMS1"/>
    <dbReference type="GeneID" id="87882105"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="38"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3302856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="329" mass="36229" checksum="05A661D0E092F1ED" modified="2024-07-24" version="1">MDGYQRGDLQSAAGESMAGGLIAFSVTMALMNVVVVALRFYVRIWVIRNFGPDDWALAVTLASAIAGVILMSYGTRLGLGLHINALSLSERSAFLQLLFVSTPGYHFIIMLVKATFLLQFRRVFPLPTTKRLCDIFLVVIAIWTVVGGILAVVICLPLSKNWDPLEPTWTCPNRYRFWLAHGILHVITDVVIFVMPLPLLKTLPLPPLHKVILMGVFCLGFITCVISAVRLTTLNTSTRDPDVSWTAARTCFFSIGEVTSSILCLCIPTLRPLLGMCRCCERRTKSQDSTETGGQRFGVYLISLPSTASDAQSSARTPIWVVGTDSNRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GN70</accession>
    <name>A0AAJ0GN70_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetyltransferase B complex non catalytic subunit-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_486591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MDM20/NAA25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718868.1">
        <property type="nucleotide sequence ID" value="XM_062866373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GN70"/>
    <dbReference type="GeneID" id="87885202"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031416">
        <property type="term" value="C:NatB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019183">
        <property type="entry name" value="NAA25_NatB_aux_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767:SF3">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 25, NATB AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09797">
        <property type="entry name" value="NatB_MDM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3303088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1018" mass="113914" checksum="3D3BA2C5BE167CEF" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2025-04-02" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GNM9</accession>
    <name>A0AAJ0GNM9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Gryzun, putative trafficking through golgi-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_568940</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719079.1">
        <property type="nucleotide sequence ID" value="XM_062870788.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87889617"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012880">
        <property type="entry name" value="Gryzun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021773">
        <property type="entry name" value="TPC11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14374">
        <property type="entry name" value="FOIE GRAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14374:SF0">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11817">
        <property type="entry name" value="Foie-gras_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07919">
        <property type="entry name" value="Gryzun"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trafficking protein particle complex subunit 11" evidence="3">
        <location>
            <begin position="343"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="Gryzun putative trafficking through Golgi" evidence="2">
        <location>
            <begin position="638"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="domain" description="Gryzun putative trafficking through Golgi" evidence="2">
        <location>
            <begin position="1228"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="983"/>
            <end position="1006"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
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                <person name="Ng V."/>
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                <person name="Ohm R."/>
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                <person name="Ament-Velasquez S.L."/>
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                <person name="Gladieux P."/>
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                <person name="Labutti K."/>
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                <person name="Steindorff A."/>
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                <person name="Ament-Velasquez S.L."/>
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                <person name="Powell A.J."/>
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                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Brannstrom I.O."/>
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                <person name="Kuo A."/>
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                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719839.1">
        <property type="nucleotide sequence ID" value="XM_062867968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQ38"/>
    <dbReference type="GeneID" id="87886797"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911">
        <property type="entry name" value="ACYL-MALONYL CONDENSING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911:SF6">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="7">
        <location>
            <begin position="99"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="438"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="448"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="476"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3304059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="496" mass="53209" checksum="3E255A9598BBE9A7" modified="2024-07-24" version="1">MLPSLNPRQTPRKTTRLGDDSDDALDSIPLEELSSNKPSSPFLNPHVSRSLSASPFSEHGRLSPCQTRALSPAPYTHPLQTRRAAIAQCLRRFWADNRAVLLVGVSQFFGALMNLAAKLLEMESGMRPMQILFARQSMTTALSCLYMWWNMIPDFPLGPRGVRGVLLIRGISGFFGIYGMWFSMRYLPLAEATVITFLAPMLSGYMCDLLLKDPFTRREQLASFIAIAGVVLIARPTSLFGSGHSDDGGVLPADQTNSTIIPEIPTVFARVAGAGTNETEPTPAQRLLAIMVALVGVLGAAGAYTAIRCIGKRAHPLITVTYFSACSTVVSTVALLVLPHVGWPDMNFAGLLLSSAYEWFLLLSLGTCGFVMQFIMTAGLGGSDGRNANRATAMTYTHMLFAAAFDRWVFDHRMGVVSVVGCGLIVGSALWAALGKKTPAVSPGEGGGGRERSGDVERNAVGGGEEAVPMLGDGGVGDEGEEEAEGEQRRSPRNHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQA7</accession>
    <name>A0AAJ0GQA7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cell wall protein PhiA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_232133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719963.1">
        <property type="nucleotide sequence ID" value="XM_062862961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQA7"/>
    <dbReference type="GeneID" id="87881790"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042552437" description="Cell wall protein PhiA" evidence="1">
        <location>
            <begin position="18"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3304183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="187" mass="19811" checksum="D18A68C942D9AEF6" modified="2024-07-24" version="1">MQLNAVVLSLFAAAASAAPTDSSERKFGIMALRSASPIHFAMAGASQGKLGFNFPDSKNDAQCTDGQKPTAATFTLKDGELYLYGSDQVQQIYVDRSGMGQGVLGYFNKDVSRPPRNGELSGWSVDENDNLTFDGTPLKACPGTDNAYYIWASGADKPAGIEGCLGFSARTVTKSDAVQCTYSTYSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQB4</accession>
    <name>A0AAJ0GQB4_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">LIM-domain binding protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_399602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719988.1">
        <property type="nucleotide sequence ID" value="XM_062865018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQB4"/>
    <dbReference type="GeneID" id="87883847"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029005">
        <property type="entry name" value="LIM-bd/SEUSS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10378">
        <property type="entry name" value="LIM DOMAIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01803">
        <property type="entry name" value="LIM_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="529"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="627"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="627"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="682"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3304208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="759" mass="82595" checksum="CF389E05BC21FA08" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQC0</accession>
    <name>A0AAJ0GQC0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_232588</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719979.1">
        <property type="nucleotide sequence ID" value="XM_062862965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQC0"/>
    <dbReference type="GeneID" id="87881794"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3304199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="202" mass="22571" checksum="DE2ABD932EA1A8FA" modified="2024-07-24" version="1">MLMANLLCTFAHRNGSSWRAPTSTYVAGSDCSSLTPADHKGFETYSSYFPTHYEYRREQNALSDRGDDQLSFADYGSSTYTDLPNWYSRSHAKETFASKRRASDIFGGRLTNCVIFVTCLSGSGGTTARPCLARWKINRYLLRCSSLPIDPHYQKKPCSDTVFRALKDGGCFSSFCDLGVSTAVLHHQTSFCINATTEFLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ0GQQ7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_494867</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720184.1">
        <property type="nucleotide sequence ID" value="XM_062867057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQQ7"/>
    <dbReference type="GeneID" id="87885886"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3304404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="141" mass="15209" checksum="218D8E87B28C595A" modified="2024-07-24" version="1">MASERMNWDHHADHDLLTAMMQELQPSQEQLRGVMNRMHGFGYTCTVKAITQHLQKLRRKEGGPGPAAGKDDGAGPSTPKSTPKTPGGRKKNVGAAAKSTPGSAKRKKSAATAESVDDSEPDTKKVKDEKTDVKQEIASEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQY3</accession>
    <name>A0AAJ0GQY3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CI-B8 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_536715</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720294.1">
        <property type="nucleotide sequence ID" value="XM_062869569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQY3"/>
    <dbReference type="GeneID" id="87888398"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040049">
        <property type="entry name" value="Ribosomal_mS25/mL61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13274">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13274:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05047">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="5">
        <location>
            <begin position="109"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3304514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="269" mass="29785" checksum="15EB97EE0D29EC20" modified="2024-07-24" version="1">MRPGDLGPARSRQAKVVGPLVLARPRQAKNFRGSITESEPCSHHVAVRSQRPALPTVCSLSASVRKNIKMVGVLRRFNQLKALVRIRTGPGAAVLPQDVTRIHMEFAHKLNDGHMGPRKFWREALPRLKYWNPAVPMVVNRTTDNSGPATLTLYFREPGATLASDMPMPSSSNEGFAKAPAPAEGERVVTIDMKHRRSEAILKEFMDKSGAVAVTPTPQDEVELREAEEREAKGAVDRERIRRMNEEAKREKAMIAQAQSEAAAIRSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ0GRS0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_513000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720699.1">
        <property type="nucleotide sequence ID" value="XM_062868018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GRS0"/>
    <dbReference type="GeneID" id="87886847"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3304919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="225" mass="24393" checksum="9F173B94E21FD77E" modified="2024-07-24" version="1">MGWFHDAANELLNCLWDKDVATEETTEPDKFDDQLAQLKHYAAAWKLAYGKPLHEPLTPDDVRSATAFVKYIFTGQPPMESGIVLQKRLKLQTLDYMPFSILAVLYTGEDLIKVAASTFQALLEGAGKIAKWSSWPYNSELINALRQWKPAPAAVFSLNVASEAAQPPPTPAPTVIEPSVPCTAPTRFQPAPPGAAVPLSSPSPARASPDTACTALPTRPQPASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GRT4</accession>
    <name>A0AAJ0GRT4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cupredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_251259</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720490.1">
        <property type="nucleotide sequence ID" value="XM_062863183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GRT4"/>
    <dbReference type="GeneID" id="87882012"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00920">
        <property type="entry name" value="Cupredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052953">
        <property type="entry name" value="Ser-rich/MCO-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883:SF17">
        <property type="entry name" value="CUPREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883">
        <property type="entry name" value="SERINE-RICH PROTEIN, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042529522" evidence="2">
        <location>
            <begin position="18"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="163"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3304710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="205" mass="20905" checksum="69C12D5CE0B7B414" modified="2024-07-24" version="1">MQLTTLVLATLTSLASAQKTWVVAVAKNGSLTYSPDKLTAQPGEQIQFQFHAGNHTVTQSTFDQPCQPVGMHSNITGFHSGFLPAAASASTGMMPTFTITINDTKPLWLYCAQGKHCENGMVMVINEPTTNASRTLEKYKELAAKGTTVVPGAEGAGSGGTTGSTDGSTTTGDASSATPTTAGAGMLSAPGTIALVAAAAAAFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GS80</accession>
    <name>A0AAJ0GS80_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Argininosuccinate lyase</fullName>
            <ecNumber evidence="4">4.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Arginosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_398508</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-(N(omega)-L-arginino)succinate = fumarate + L-arginine</text>
            <dbReference type="Rhea" id="RHEA:24020"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="EC" id="4.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.1" evidence="4"/>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720907.1">
        <property type="nucleotide sequence ID" value="XM_062864957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GS80"/>
    <dbReference type="GeneID" id="87883786"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:L-arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01359">
        <property type="entry name" value="Argininosuccinate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.10:FF:000002">
        <property type="entry name" value="Argininosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000001">
        <property type="entry name" value="Argininosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.200.10:FF:000002">
        <property type="entry name" value="Argininosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00006">
        <property type="entry name" value="Arg_succ_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029419">
        <property type="entry name" value="Arg_succ_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00838">
        <property type="entry name" value="argH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="ARGININOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814:SF1">
        <property type="entry name" value="ARGININOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14698">
        <property type="entry name" value="ASL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00145">
        <property type="entry name" value="ARGSUCLYASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarate lyase N-terminal" evidence="7">
        <location>
            <begin position="40"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Argininosuccinate lyase C-terminal" evidence="8">
        <location>
            <begin position="393"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3305127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="487" mass="53425" checksum="9A5684392DCCC13E" modified="2024-07-24" version="1">MAPTTAPALLWGGRFTGTINHIDRVHVFLELTASFSWPGAIDDLMFQFNESLSFDKVLYKADIQGSITWAKALRKLDILSDEELDKIVSGLKQVEKEWEEGKFVIDAKSDEDIHTANERRLGELIGSAAGKLHTGRSRNEQVGVDMRLWAGEQLTDIAGALKDLLSVSASRAREALPILMPGYTHLQRAQPVRFSHWLLSHATFLKGDLERLQGVQERVSACPLGVGALAGNPFGIDREFMARELGFRSVHPNSLCAVADRDFVVEILQWASLLMAHLSRLAEDLILFSTAEFGFVQVADAYSTGSSLMPQKKNPDSLELIRGKAGRVMGQASGFLASLKSLPTSYNKDLQESVEPMIDCIKTVSNCVRITQGVLATLKINGDKMKAALTDDMLATDVADYLVRKGVPFRQTHHIAGAIVRRAEEAGVSISALPLQDLKDISPLFEDDVAQVFDFEKSVERRSTIGGTSKSSVLAQIDAIEAYVAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GSE5</accession>
    <name>A0AAJ0GSE5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tf2-1-like SH3-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_493265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720845.1">
        <property type="nucleotide sequence ID" value="XM_062866932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GSE5"/>
    <dbReference type="GeneID" id="87885761"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tf2-1-like SH3-like" evidence="2">
        <location>
            <begin position="15"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3305065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="161" mass="19029" checksum="65971F7DB1927ADA" modified="2024-07-24" version="1">MSERTIASRIGGELDMVYLRLHKGYHLPGKPSRKWSSQRAGPFKIVRKVYNLAYKLDFPKSWKVWPVVSAAQLYKVPQEPDPFERVTPPPPPVIRNKKPAVEYLVKYLGWEDMHNQWEYKEKGIKRKEYEAIKEIPKLENQIRIDLPVRKDLGEFQKIDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GSL7</accession>
    <name>A0AAJ0GSL7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Serine hydroxymethyltransferase</fullName>
            <ecNumber evidence="12">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0T15DRAFT_531527</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 12">Interconversion of serine and glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 12">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 12">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="12"/>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720950.1">
        <property type="nucleotide sequence ID" value="XM_062869253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GSL7"/>
    <dbReference type="GeneID" id="87888082"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000097">
        <property type="entry name" value="Serine hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000586">
        <property type="entry name" value="PRK00011.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF57">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 12" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9 12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="13">
        <location>
            <begin position="72"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3305170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="545" mass="59610" checksum="2677E4E1BECB8DA8" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GSV6</accession>
    <name>A0AAJ0GSV6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tetratricopeptide repeat and J domain-containing co-chaperone DNJ1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_532454</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721267.1">
        <property type="nucleotide sequence ID" value="XM_062869310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GSV6"/>
    <dbReference type="GeneID" id="87888139"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000083">
        <property type="entry name" value="DnaJ and TPR domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000224">
        <property type="entry name" value="DnaJ and TPR domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051727">
        <property type="entry name" value="DnaJ_C3_Co-chaperones"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44140">
        <property type="entry name" value="LD25575P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44140:SF2">
        <property type="entry name" value="LD25575P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042602862" description="Tetratricopeptide repeat and J domain-containing co-chaperone DNJ1" evidence="9">
        <location>
            <begin position="24"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="69"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="10">
        <location>
            <begin position="403"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="466"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="480"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00073740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3305487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="519" mass="57146" checksum="D52158624A3D860E" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GTS0</accession>
    <name>A0AAJ0GTS0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_485261</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721480.1">
        <property type="nucleotide sequence ID" value="XM_062866283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GTS0"/>
    <dbReference type="GeneID" id="87885112"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="90"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="189"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3305700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="285" mass="30323" checksum="1A487EDEAA5F5400" modified="2024-07-24" version="1">MAGQKGSKQPFWLGGAAASMAVCFTQPAAGEPSSTHADWPLPTGIMSLWSGLSASILRQSTYSTARFGLYTVLSRQLQQRSGTSKLSTTSTIACAGVAGGLAGMVGNPTEVILVRMCADAAKPSAERFRYSDAVTGLYRIAKEEGIRVFGRGLSANILRSVLMMTKDVSQIAPYAAAKRAILSRTQMQDDIRTHALASLFAGTVATTACAPADVLKSRIQSAAKGSSVMQVIRDGLRGEGMAFLMKGWTPAWLRLTPHTILTFVFMEKLQELVNLTASSPVRATI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GTV1</accession>
    <name>A0AAJ0GTV1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Amino acid permease-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_494094</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721744.1">
        <property type="nucleotide sequence ID" value="XM_062866992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GTV1"/>
    <dbReference type="GeneID" id="87885821"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000017">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004762">
        <property type="entry name" value="Amino_acid_permease_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00913">
        <property type="entry name" value="2A0310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF1">
        <property type="entry name" value="GENERAL AMINO-ACID PERMEASE GAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="155"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="448"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="477"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="519"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="560"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="10">
        <location>
            <begin position="124"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3305964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="632" mass="67880" checksum="B9F4EAA6DDCC1BBD" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GU15</accession>
    <name>A0AAJ0GU15_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="9">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_397551</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721615.1">
        <property type="nucleotide sequence ID" value="XM_062864908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GU15"/>
    <dbReference type="GeneID" id="87883737"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF103">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MANNOSIDASE MNL2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="34"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="410"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="699"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="427"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="488"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="721"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="535"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="652"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="781"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="868"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="609"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3305835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="877" mass="97180" checksum="D369E3468E4A18E9" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GU94</accession>
    <name>A0AAJ0GU94_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_485659</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3306248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722028.1">
        <property type="nucleotide sequence ID" value="XM_062866302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GU94"/>
    <dbReference type="GeneID" id="87885131"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009403">
        <property type="term" value="P:toxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000047">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF230">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3306248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="502" mass="56748" checksum="2FFD7813060B7B13" modified="2024-07-24" version="1">MPIRDGAGSFKCDSEVPVLTVMCLGYLIWTAAYNVFLHPLRSYPGPTLWAMSRIPYTRGFLSGDMHHRILELHKTYGPVVRVAPDFLSYSHPDALKEIRGHRKGGRVEHPKDPVHVGANVDSVFGADRDNHTRMRRAMAHGFSAQAIAEQQPIIQKYVDLMIRRLHEECAGGTRSVDVVKWFNFATFDIIGDLAFGEPFSCLEGSTYHPWVAMIFSSVKDLAWSINLNRYPAIAPLLKRLLVPKEVMSKFAQHRALSEERVRNRLAIDTDRPDFLDAMTKRRGDAKELTFQELVGNASLLITAGSETTATALSAATYYLGMNPRALARLTAEVRSTFAREDEIDLLSVQNLTYMLAVLDEALRMYPPAPGGQPRKIHKDGDVILGRFVPGGTVVENWQWPMCHNPAWFTRPDDFVPERWLGDPRFAGDTKEARQPFSYGPRNCIGKNLAYAEMRLILARVVWAFDIKLAEDAKGWDERSKMYLLWEKGPVNVFLTPRESESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GUC0</accession>
    <name>A0AAJ0GUC0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_398589</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3306000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062864960.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87883789"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
    </dbReference>
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        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF39">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05010)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="401"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="469"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="492"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="568"/>
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        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="97"/>
            <end position="588"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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    </feature>
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        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3306000.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="661" mass="71964" checksum="6A2463005472037E" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GUD3</accession>
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            <fullName evidence="4">FAD binding domain-containing protein</fullName>
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        <name evidence="4" type="ORF">B0T15DRAFT_222349</name>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062862828.1"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3306239.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="572" mass="62860" checksum="C8A3429B150D721B" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GUH0</accession>
    <name>A0AAJ0GUH0_9PEZI</name>
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        <submittedName>
            <fullName evidence="10">Major facilitator superfamily-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_217645</name>
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    <organism evidence="10 11">
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        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3306075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721855.1">
        <property type="nucleotide sequence ID" value="XM_062862761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GUH0"/>
    <dbReference type="GeneID" id="87881590"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000335">
        <property type="entry name" value="Siderochrome iron transporter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000284">
        <property type="entry name" value="Siderophore iron transporter mirB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="353"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="390"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="478"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="559"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3306075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="594" mass="64998" checksum="CB3120DC526ED961" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GUJ1</accession>
    <name>A0AAJ0GUJ1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein transport protein BOS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0T15DRAFT_137682</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the BOS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722109.1">
        <property type="nucleotide sequence ID" value="XM_062861838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GUJ1"/>
    <dbReference type="GeneID" id="87880667"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15863">
        <property type="entry name" value="SNARE_GS27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000054">
        <property type="entry name" value="Protein transport protein BOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027027">
        <property type="entry name" value="GOSR2/Membrin/Bos1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230:SF1">
        <property type="entry name" value="GOLGI SNAP RECEPTOR COMPLEX MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028865">
        <property type="entry name" value="Membrin-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="106"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3306329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="303" mass="32467" checksum="E9A29B76B3EB4924" modified="2024-07-24" version="1">MNTTFNSALKQRTTIRKDLSLLSNPTTDNNPQQQPQQVTPAALGSLSASLTAFARTIDEYHALAKQELNKAKQEKALERIRDFRAELADFRAQLDTLKAAREEAAHAENRSELLGRRPFAASTPENPYNNSSSVGGGGYGLNRSGGGSGGGGHARTTSIAERGIAAPSPSSGVGGFGMGSGDVTRESHALREQAFFASTHSALDEYIARGQAVLGDLGQQREMLKSTQRKLYSVGNTLGISGDTIRMIERRRSRTSGSSGPGSLCFSCFAGWCCIICGRDRSLMGGDWWCFRLARSSGVGVRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GUU6</accession>
    <name>A0AAJ0GUU6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pre-rRNA-processing protein PNO1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Pre-rRNA-processing protein pno1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_492083</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for small ribosomal subunit (SSU) synthesis. Has a role in the processing of early nucleolar and late cytoplasmic pre-RNA species.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the small ribosomal subunit, ribosomal RNA processing complex (SSU RRP complex).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PNO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722326.1">
        <property type="nucleotide sequence ID" value="XM_062866836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GUU6"/>
    <dbReference type="GeneID" id="87885665"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22392">
        <property type="entry name" value="KH-I_PNO1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000009">
        <property type="entry name" value="RNA-binding protein PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055211">
        <property type="entry name" value="KH_PNO1_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826">
        <property type="entry name" value="RIBONUCLEASE Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF13">
        <property type="entry name" value="RNA-BINDING PROTEIN PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22891">
        <property type="entry name" value="KH_PNO1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="10">
        <location>
            <begin position="159"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3306546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="246" mass="26864" checksum="2FC399540AD7FB2A" modified="2024-07-24" version="1">MPAPTALLQPSPAPEAALAPAPQQEDELLVDMQESSVTEPSAVAAPTATEDTDMAIDEEGRPRFAPGNDVDPVRRAETRKIPIPPNRIYPPLVDHCKLQVRMNIKEKRVELRSSKFTASNDALQMGADFVSAFAMGFDIDDAIALLRLDSLYIQSFDIRDVRQTLGQDALGRAIGRIAGKDGKTKFAIENATKTRIVLAGSRVHILGAFENIGMARESIVSLVLGAQPGKVYNNLRIIASRMKERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GUX0</accession>
    <name>A0AAJ0GUX0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Gfd2/YDR514C-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_147393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722402.1">
        <property type="nucleotide sequence ID" value="XM_062861949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GUX0"/>
    <dbReference type="GeneID" id="87880778"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040151">
        <property type="entry name" value="Gfd2/YDR514C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048519">
        <property type="entry name" value="Gfd2/YDR514C-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083:SF1">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21762">
        <property type="entry name" value="DEDDh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfd2/YDR514C-like C-terminal" evidence="1">
        <location>
            <begin position="108"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3306622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="345" mass="38505" checksum="B7EF0E44A3E87146" modified="2024-07-24" version="1">MMTCQTTVGALPVHTTPYGAPELINFHYSFPRGPPPAVRPPSLEKIDMEAITQSSNADPPHMGLLRDETLALRGLFGYSNHVPAQPCNPVLDFPGTKLHKTEVWDVRFLGLDVDALQEIEQGIQQFHIGVSIFDTRLLWKSALGLPHPGQENKMTESHYFVVGSPKFSRRKSNKFLFGKFEALSLSDLRARLEGMTLHRDLILVAHGIQRELTVLQRVNIDLRPRYVLDTVKAAQHPLQLSYRCSLEQLLAEFDISFHSLHVAGNDAHFALRAMLMITVRDAERQLDASVLPSWLPTLRAIAHAPLLPADNKGCSELGTAKRSSSCLEILMLHAMAICQQLYPGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GUY8</accession>
    <name>A0AAJ0GUY8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_395777</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722432.1">
        <property type="nucleotide sequence ID" value="XM_062864797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GUY8"/>
    <dbReference type="GeneID" id="87883626"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="49"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="214"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="632"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="728"/>
            <end position="803"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="965"/>
        </location>
    </feature>
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        <location>
            <begin position="162"/>
            <end position="200"/>
        </location>
    </feature>
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        <location>
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            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
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            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="378"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="442"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="955"/>
            <end position="965"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3306652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="965" mass="104743" checksum="5DB28AD9076A66AB" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GVK0</accession>
    <name>A0AAJ0GVK0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial</fullName>
            <ecNumber evidence="6">1.1.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Isocitric dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">NAD(+)-specific ICDH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0T15DRAFT_393603</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
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        <reaction evidence="1">
            <text>D-threo-isocitrate + NAD(+) = 2-oxoglutarate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:23632"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.41"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Octamer of two non-identical subunits IDH1 and IDH2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.41" evidence="6"/>
    <dbReference type="EMBL" id="JAUDZG010000003">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722751.1">
        <property type="nucleotide sequence ID" value="XM_062864693.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87883522"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004449">
        <property type="term" value="F:isocitrate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000003">
        <property type="entry name" value="Isocitrate dehydrogenase [NAD] subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004434">
        <property type="entry name" value="Isocitrate_DH_NAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00175">
        <property type="entry name" value="mito_nad_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF34">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="15">
        <location>
            <begin position="54"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3306971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="383" mass="41293" checksum="3BE67941014D45C8" modified="2024-07-24" version="1">MLALRSIAAPVQRQCFRAAPRAGITLALQNRRQYSSQDAVAKFNGQKDAQGRYTVSLIEGDGIGPEIAVAVKDIFAAAKTPIVWEPINVDPILKDGKTAIPDAAIESIRKNKIALKGPLATPIGKGHVSLNLTLRRTFNLFANLRPCRSVAGYKTPYDNVDTVLIRENTEGEYSGIEHVVVDGVVQSIKLITREASERVLRFAFQHARSIGRKKVRVVHKATIMKMSDGLFLTVGNQIAKEFPDIEFDAELLDNTCLKMTTDPTPYNDKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDECSIFEAVHGSAPDIAGKGLANPTALLLSSMMMLRHMGLTDYADRIEKAAFATLAEGKALTGDLGGKAKTSEFAAAIIEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GW03</accession>
    <name>A0AAJ0GW03_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lysine-specific metallo-endopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_553639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722963.1">
        <property type="nucleotide sequence ID" value="XM_062870330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GW03"/>
    <dbReference type="GeneID" id="87889159"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042601566" description="Lysine-specific metallo-endopeptidase domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3307183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="311" mass="34063" checksum="19B7922D8A88CAE9" modified="2024-07-24" version="1">MTSPLLFLLALCASLLSLTSAQTSLVFNRSWQPCGTFDRVLGGIPEADPVDDCTNPEQEAAIRQAFNDAVVLAANARDGMRNGPRPHVWAYYDRVFKHATTPGATYSWRKVAHLRPSSPPNEIPNEIIFHCGDRWHAAVARRATNYGVTGDASSPQSGLGAHVCEASSGAFMSRIKSGTFPPDVFSDFGPQGAFRSGVHITICPHFYDWPALNNIRTVTENLEFAHQNNQAWFMLHEMMHAYSESILDAGYGHAGIVNVSDRILPPDRLHITPLTNADTWAIFAMVISPVGGMNLWDWTTGFAVRTPASPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GW72</accession>
    <name>A0AAJ0GW72_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Kinesin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_529774</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723046.1">
        <property type="nucleotide sequence ID" value="XM_062869130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GW72"/>
    <dbReference type="GeneID" id="87887959"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00381">
        <property type="entry name" value="KINESINLIGHT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3307266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="159" mass="18037" checksum="969933195655215A" modified="2024-07-24" version="1" fragment="single">MEAFKRVLGEEHPSTLASMANLASTYRNQGRWKEAESLGLQVMETFKRVLGEEHPDTLTSMANLALTYTNQGRWKEAEAVEVQVMETRKRVLGEEHPDTLTSMANLAFTWKSQGRLSDALELMQNCLYLRRQVLGSDHPHTVSTLSLVTDWLDKKDNGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GX34</accession>
    <name>A0AAJ0GX34_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Marvel domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_185889</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723474.1">
        <property type="nucleotide sequence ID" value="XM_062862374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GX34"/>
    <dbReference type="GeneID" id="87881203"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032126">
        <property type="term" value="C:eisosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070941">
        <property type="term" value="P:eisosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052649">
        <property type="entry name" value="NCE102-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28165:SF2">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28165">
        <property type="entry name" value="NON-CLASSICAL EXPORT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="6">
        <location>
            <begin position="6"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3307694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="183" mass="19429" checksum="471C42B161E46CE4" modified="2024-07-24" version="1">MHRAIPLGLRTIQFLIAVTILGLAAAMIRAQVLGSAPTTVRYSTFTGGFGILVGLVGIASLFASFIPDLVPLVLDGLAGLLFLAGGIAWAVGLRGVQSCKDPYRMLQNSLLNWGTIGSGDDTRYGVVRPGDDDKAWYNRLRGNCQRAQADEVLQFISVAFALGLVGLGYLQMRRGRGAGGYIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GXN8</accession>
    <name>A0AAJ0GXN8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Actin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_95678</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723843.1">
        <property type="nucleotide sequence ID" value="XM_062871490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GXN8"/>
    <dbReference type="GeneID" id="87890319"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10224">
        <property type="entry name" value="ASKHA_NBD_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.36.70:FF:000001">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000001">
        <property type="entry name" value="Actin, muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000404">
        <property type="entry name" value="Major actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3308063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="375" mass="41623" checksum="D4CCE5C47901C917" modified="2024-07-24" version="1">MEEEVAALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHHGIMIGMGQKDSYVGDEAQSKRGILTLRYPIEHGVVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPINPKSNREKMTQIVFETFNAPAFYVSIQAVLSLYASGRTTGIVLDSGDGVTHVVPIYEGFSLPHAIARVDMAGRDLTDYLMKILAERGYTFSTTAEREIVRDIKEKLCYVALDFEQEIQTAAQSSSLEKSYELPDGQVITIGNERFRAPEALFQPSVLGLESGGIHVTTFNSIMKCDVDVRKDLYGNIVMSGGTTMYPGLSDRMQKEITALAPSSMKVKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GY12</accession>
    <name>A0AAJ0GY12_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Aspartokinase</fullName>
            <ecNumber evidence="9">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0T15DRAFT_100909</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>L-aspartate + ATP = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the aspartokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="9"/>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723984.1">
        <property type="nucleotide sequence ID" value="XM_062861359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GY12"/>
    <dbReference type="GeneID" id="87880188"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009090">
        <property type="term" value="P:homoserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2130.10:FF:000001">
        <property type="entry name" value="Bifunctional aspartokinase/homoserine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1160.10:FF:000023">
        <property type="entry name" value="Probable aspartokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2130.10">
        <property type="entry name" value="VC0802-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054352">
        <property type="entry name" value="ACT_Aspartokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21499">
        <property type="entry name" value="ASPARTATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21499:SF59">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22468">
        <property type="entry name" value="ACT_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <source>
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        </source>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="RuleBase" id="RU003448"/>
        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="523" mass="57114" checksum="18585FBCF54DE896" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
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                <person name="Cros-Aarteil S."/>
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
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        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="nucleotide sequence ID" value="XM_062870245.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0051087">
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        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
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            <end position="286"/>
        </location>
    </feature>
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        </location>
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        </location>
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        </location>
    </feature>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724162.1">
        <property type="nucleotide sequence ID" value="XM_062861438.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87880267"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042618612" description="Siderophore biosynthesis" evidence="2">
        <location>
            <begin position="21"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3308382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="19771" checksum="ABF1102FC1525DB4" modified="2024-07-24" version="1">MTKSVLPALALLMLATPALSACGTYTYGTCADGIVHWFDPNTGEICDPLNCGGDRAGPLRTDVPGCPAYKGTLTRPTEPSYMPCWTGFSSTAAATTTAATTTTTVVSSHSSAAPSASSGSGQSQVGSTTAGTGASSTAPADAPSPTASSTTMLTTTAPTSTSPADTGTGAAGASSTTVSTGAGSVMSGSWIAVVAGVGLGALAIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GYH5</accession>
    <name>A0AAJ0GYH5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Permease family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_490812</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
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                <person name="Powell A.J."/>
                <person name="Barry K."/>
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                <person name="Debuchy R."/>
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                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
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    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
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                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="entry name" value="Xan_ur_permease"/>
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    </dbReference>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005697"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
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                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
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                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
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                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_062871525.1"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12323:SF0">
        <property type="entry name" value="CALCIUM HOMEOSTASIS ENDOPLASMIC RETICULUM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12323">
        <property type="entry name" value="SR-RELATED CTD ASSOCIATED FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="410"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="444"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="454"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="501"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
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            <end position="583"/>
        </location>
    </feature>
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        <source>
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    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3308155.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Cros-Aarteil S."/>
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
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                <person name="Ohm R.A."/>
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                <person name="Lalanne C."/>
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                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724446.1">
        <property type="nucleotide sequence ID" value="XM_062864562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GYT2"/>
    <dbReference type="GeneID" id="87883391"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003935">
        <property type="term" value="F:GTP cyclohydrolase II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00641">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="entry name" value="GTP cyclohydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022163">
        <property type="entry name" value="GTP_CH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005536">
        <property type="entry name" value="PRK07198.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47259">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47259:SF2">
        <property type="entry name" value="URACIL-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12471">
        <property type="entry name" value="GTP_CH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="RibA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GTP cyclohydrolase N-terminal" evidence="7">
        <location>
            <begin position="100"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="GTP cyclohydrolase II" evidence="6">
        <location>
            <begin position="335"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="61"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3308666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="515" mass="56754" checksum="53593B358C44E188" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ0GZ53_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">14-3-3 domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">B0T15DRAFT_121012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724636.1">
        <property type="nucleotide sequence ID" value="XM_062861624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GZ53"/>
    <dbReference type="GeneID" id="87880453"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.20">
        <property type="entry name" value="14-3-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036815">
        <property type="entry name" value="14-3-3_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48445">
        <property type="entry name" value="14-3-3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3308856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="299" mass="32594" checksum="61D7606CDDABC8D1" modified="2024-07-24" version="1">MASSEVDQKFLGKLAKAVENDNPLLASVLFRILGLSINLSNQLIKARKQRRQDGVQSAEALDLICHIIWLSREGLVLLQQYVLPMVGNYVELKVLAYKLRASFYHIFVLFHNTPPVSTMSVINTPEGQSTSSVSGFPSTRVDKGKGIARDDQGGLKSKGGPVGPPPGFGPAPPTAFLMKPGDYLPEAHQYFREAVQLAEELLWGSHSLRLSVKTEYAAFLYECVHDAEGSRKLAKDTIAEVYEATEGIDNDMFNDACELVTVLGKMMKRGLGSNKGSSPGTQGTLRVDDAERSVPPGMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GZH1</accession>
    <name>A0AAJ0GZH1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_509436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3309041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724821.1">
        <property type="nucleotide sequence ID" value="XM_062867784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GZH1"/>
    <dbReference type="GeneID" id="87886613"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="519"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="603"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3309041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="642" mass="66879" checksum="81BE13DCB7976173" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GZK8</accession>
    <name>A0AAJ0GZK8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_128663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3309068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724848.1">
        <property type="nucleotide sequence ID" value="XM_062861721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GZK8"/>
    <dbReference type="GeneID" id="87880550"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3309068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="222" mass="24674" checksum="B28830285739A55C" modified="2024-07-24" version="1">MSLPVRAASRVSARTLLVKVSPAPVTLTERRAILQVLKRHGEVEVFKKLHDPGHFISVFSHAEKAADIVARSPLEFDYVDQQHDGKGTANSPTSGPSHPQKTFYVQIKETLLYQHRTHIRENPIYGRWPAPNDNLLLEHSMTKAALSQAVPQGMAHAGLVDWATCGQLDAQETLTSKADHIAARRRRRMNESKFESLVGAYNARHAASGRLKEGDHGKDVHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H0C3</accession>
    <name>A0AAJ0H0C3_9PEZI</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_4421</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PHAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725273.1">
        <property type="nucleotide sequence ID" value="XM_062865936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H0C3"/>
    <dbReference type="GeneID" id="87884765"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="PHAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039156">
        <property type="entry name" value="PHAF1/BROMI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13465:SF2">
        <property type="entry name" value="PHAGOSOME ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13465">
        <property type="entry name" value="UPF0183 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03676">
        <property type="entry name" value="PHAF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="464"/>
            <end position="483"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="279"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3309493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="511" mass="56258" checksum="7FD12F6347218914" modified="2024-07-24" version="1">MSSLFSAQLHPGRALGFLVLGASLHDILTRIKAEPQRFPNIEVFYDPKDPVKQPVTIGLPANGVRMRFDGPEQRLRLIEVLDFTKNHIFLRPANDKERDLVRPSQGASAATDTTPGPTFRHIYQRFLGPTYDGEYAAAAEIYILSYPGVAFTFPLKKKEYSSSKDVVSLLPSTAVPKSMAVFSGDSFAQARQTMWTEILPSIKTFAPLAKGKDMCPDEVSLVKIHGGGRLQLMRKWTNNSFSIMLGETTPQQLVAELGPPDAIYRKNDQGMYIHKLRAASNTMTQPSGSDLKRQDDLTDTDQSSHQASDEYDSDDEAVDDGVVANVSGECFYNYFYLGFDVLVSTPTAPSQPPPSQGGNPYIPGTPADRLVATKLILHGNVPGSYPFNRHRRCRWELIYLSPSSADSSPDAVINSETPFPQIEERLREEWKSIYPSEAEARQKQRGMVLNRGWGDSPGSSCELLGGWEESGGTNPGVGKGKAEDSTTTLYGFPGLVFEVLKNGYVSAVTVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H0G5</accession>
    <name>A0AAJ0H0G5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_515644</name>
    </gene>
    <organism evidence="3 4">
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725272.1">
        <property type="nucleotide sequence ID" value="XM_062868209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H0G5"/>
    <dbReference type="GeneID" id="87887038"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038769">
        <property type="entry name" value="MTC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38426">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38426:SF1">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1185"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="567"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="629"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="851"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="935"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="978"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="651"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="671"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="723"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="743"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="775"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="935"/>
            <end position="946"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3309492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1228" mass="134748" checksum="BB9626FE9B95663B" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H187</accession>
    <name>A0AAJ0H187_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">chitinase</fullName>
            <ecNumber evidence="4">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0T15DRAFT_570628</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="4"/>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725753.1">
        <property type="nucleotide sequence ID" value="XM_062870841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H187"/>
    <dbReference type="GeneID" id="87889670"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06548">
        <property type="entry name" value="GH18_chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.10:FF:000005">
        <property type="entry name" value="Endochitinase B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000095">
        <property type="entry name" value="Endochitinase B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF384">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 12 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042475954" description="chitinase" evidence="14">
        <location>
            <begin position="21"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="15">
        <location>
            <begin position="122"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="63"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="63"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3309973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="509" mass="54161" checksum="DE315C3C681098B0" modified="2024-07-24" version="1">MPSSLSLLVAPLLLLSTASGLPQVQDIELGPGEDVAVACECPEVTVVTVVTVVTTTVWMTEPTSILSPTSSSGSTTLTSTPLPSTTPCSSSITETSSVPIDPTPSSPPGNGNGTGSPPPSGYRNALYFTNWGIYGANFQPQQLPADKITHVLYAFADIASDGEVKSSDSYADLEKHYPGDSWNDVGLNAYGCVKQLYKLKKQHRQMKTLLSIGGWTYSPKFAPVAATEAGRQRFCNSSVTLLKDWGFDGLDIDWEYPSDAQQAQDFVALLRTCRDALDAYAAQHAPGYHFILTIAAPAGPQNYNTLAMEAMDPLLDAWHVMAYDYAGSWDTTSGHQANLYPDPTNPQATKFSTDRAVRDYLARGTPPHKILLGLPLYGRAFEGTKGLGQPYTGVGQGSIQNGIWLYKDLPRPGATELYDDVAKASYSFNAAAGQLVSYDTVGSAAVKAGYLVEHGLGGAVFWEAAGDKNGSESLVGTLAAGMGQLEAAANLLSYPASRYENIRKGVPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H1P1</accession>
    <name>A0AAJ0H1P1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_17443</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725679.1">
        <property type="nucleotide sequence ID" value="XM_062862235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H1P1"/>
    <dbReference type="GeneID" id="87881064"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3309899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="475" mass="52177" checksum="4D1BD8029B3AC585" modified="2024-07-24" version="1">MSPPLFRIPVPVMMPLPVAPASKLQVRDEQNDGGKPHAQLAVFIFAGLAGGVALMFLTRFLYRRFFRSRYRYKPAIHQEDSPATRQIGRRHQDAVEDALTDAYVRNDDSNPSTAAVSEVHRSASVRSVMTLPPYRPKPTETEVVLGREGERDGMDVVVEMRTAEEEEALRDEEMETLYQIRAARRRIIEEREERRRRRREARENNDFGALRQIREQGRGSTTHDTSVIEGLRQSHERVREARQRAVNSIAYADVGIAHADGTRVRTNSTESSERIGLLSDAASISAGSLFRRRDRSASATLSIDTSLTLHDRAESPALSTTGGSGMYRLASAGRTRSRTNSGATTPRIPTPSVSTTPLAGSSPELVDAEDADLGDIGIPPPGYDEVSLGEVTPMHSPRSSDVSGRASPYPDPPPDYPGPGPADARNSRLSAHMEDLAAQARGDDNARTRGGVPRRPSLRLQQVPQIVIEPSSARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H381</accession>
    <name>A0AAJ0H381_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mitochondrial small ribosomal subunit Rsm22-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_520065</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Mitochondrial ribosome (mitoribosome) assembly factor. Binds at the interface of the head and body domains of the mitochondrial small ribosomal subunit (mt-SSU), occluding the mRNA channel and preventing compaction of the head domain towards the body. Probable inactive methyltransferase: retains the characteristic folding and ability to bind S-adenosyl-L-methionine, but it probably lost its methyltransferase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726768.1">
        <property type="nucleotide sequence ID" value="XM_062868471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H381"/>
    <dbReference type="GeneID" id="87887300"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052571">
        <property type="entry name" value="Mt_RNA_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015324">
        <property type="entry name" value="Ribosomal_Rsm22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13184">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13184:SF5">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09243">
        <property type="entry name" value="Rsm22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="62"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="826"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="832"/>
            <end position="842"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3310988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="848" mass="94785" checksum="B34478DCA72E3512" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H3C5</accession>
    <name>A0AAJ0H3C5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_489408</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726535.1">
        <property type="nucleotide sequence ID" value="XM_062866597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H3C5"/>
    <dbReference type="GeneID" id="87885426"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054208">
        <property type="entry name" value="DUF6914"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21858">
        <property type="entry name" value="DUF6914"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3310755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="169" mass="18937" checksum="ACE0EC1F3B32BDF0" modified="2024-07-24" version="1">MPRSKEFYGDPIEEDTLYVALYERKAVGEAYHWALLLTGPGEAGRIHQTTDRTGSWAYEIREVEQVQPTRSMICLIGIGHIPPEKRAEAEEAMKSVHVPAQGGNLRSGEPFNCRTWLKLVISVLQKEVILKLPLHVEDVETRCRIKAGALLKPNDPEGKKLPSVTARIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H3W4</accession>
    <name>A0AAJ0H3W4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pre-rRNA-processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_72186</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the RIX1 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the IPI1/TEX10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727129.1">
        <property type="nucleotide sequence ID" value="XM_062871244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H3W4"/>
    <dbReference type="GeneID" id="87890073"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120330">
        <property type="term" value="C:rixosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024679">
        <property type="entry name" value="Ipi1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056">
        <property type="entry name" value="REGULATOR OF MICROTUBULE DYNAMICS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056:SF2">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12333">
        <property type="entry name" value="Ipi1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Pre-rRNA-processing protein Ipi1 N-terminal" evidence="7">
        <location>
            <begin position="131"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3311349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="329" mass="35861" checksum="1E63D40E58E61062" modified="2024-07-24" version="1">MGSSTKKKKEKKKDFQKLKLKVGKAKPKASNFTDTSFKSKSIVVNQQTLVAESSDPAEQFKQNLSLAINAKSDNQRRDALAYITNQLSADTPNNPVGTSGVLTKLLPLMSDGAASVRTQLLKLFRSLPPAEVGPHVEKILMYVRSGMTHLSNDIRSDTLNVLEWVLDVAGDETVSCPGGWLKTLNSFSSMLGWNPSVGSAMSAKGWTSSSRPTLGTKKGPEAQARQIQVLAKFIQTGFRPEAPVPYNAVAYWDNIYCLPGMPNPFAYLNLFGTPRDEDSEMYPDRISRQRVFDAKWRAAIAAGMDGAKKEGGTVGRAAATLDKAMNGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H410</accession>
    <name>A0AAJ0H410_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_521478</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727217.1">
        <property type="nucleotide sequence ID" value="XM_062868563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H410"/>
    <dbReference type="GeneID" id="87887392"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3311437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="155" mass="17291" checksum="622DDD6DD23C982D" modified="2024-07-24" version="1">MPGLLVDSKFPVCRTRFLRIVLYVLPLSTFLTLNISALFKSPPQGLTASALSRRAMQGSPYSWLQSWNHYSSCQVKVPQLLLLHLLHLPDGAITNLCLSSQLASRKCSILRLCFVQPSVSCRPVVDLPDGSWKNDLSLYVLYFILGSGQQVTIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H489</accession>
    <name>A0AAJ0H489_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_521515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727237.1">
        <property type="nucleotide sequence ID" value="XM_062868569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H489"/>
    <dbReference type="GeneID" id="87887398"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3311457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="152" mass="16667" checksum="A2A72834F953C487" modified="2024-07-24" version="1" fragment="single">LLTNLVVVKAGVVGLDFALLILAVKDVGIRGTRNLLKLRRGLRRHNSLLGIPDGNFVDHDKVRLNDFLGTENPDLVIVCILGIHYILAQEVSNAILNLGLERHELVHLIIHDDDVQLVPMSQLGGETIPVSYAHGSGHSGTHVRSDQGRHVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H4A6</accession>
    <name>A0AAJ0H4A6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Microtubule associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_427897</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
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                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        </source>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
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                <person name="Cros-Aarteil S."/>
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
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                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
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                <person name="Natvig D."/>
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                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
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                <person name="Hutchinson M.I."/>
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                <person name="Barry K."/>
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                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
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    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
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                <person name="Kuo A."/>
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                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727405.1">
        <property type="nucleotide sequence ID" value="XM_062865357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H523"/>
    <dbReference type="GeneID" id="87884186"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18626">
        <property type="entry name" value="CD_eEF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000076">
        <property type="entry name" value="Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.990:FF:000002">
        <property type="entry name" value="mRNA export factor elf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000193">
        <property type="entry name" value="Probable Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015688">
        <property type="entry name" value="eEF3_ABC2_chromodomain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047038">
        <property type="entry name" value="eEF3_chromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF14">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="8">
        <location>
            <begin position="218"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="478"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="723"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1037"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1037"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1078"/>
            <end position="1087"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3311625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1123" mass="123196" checksum="9C81B32454F134FE" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LXQ4</accession>
    <name>A0AAJ0LXQ4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Single-strand DNA deaminase toxin A-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_405018</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717417.1">
        <property type="nucleotide sequence ID" value="XM_062865278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LXQ4"/>
    <dbReference type="GeneID" id="87884107"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057517">
        <property type="entry name" value="SsdA-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24124">
        <property type="entry name" value="ANKYRIN REPEAT FAMILY A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24124:SF14">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_25, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24120">
        <property type="entry name" value="SsdA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="48"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Single-strand DNA deaminase toxin A-like C-terminal" evidence="4">
        <location>
            <begin position="189"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3301637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="307" mass="34697" checksum="543A334E74A79057" modified="2024-07-24" version="1">MSNFRDEVIRTLGLTDLHVAVIRGNVRRVLDILRSEDKRELIEARDLNGATPLMTAVLTGQLKIARLLLRNGASTRATDRKGRTALNYARTAWFEGDMAVYRRLGLPPLSPEKRGRRRRKIAEILRYPAALASCRLGGRHPCSRAVFYKNGDKRKVFQPDMHIRHGKEKCARSTVGFIVSATNPDVKTAAISGWQENIKRDRNVLSNAKYTQLVKDLAEILDFNLQPNVRLDNQGKYVPEYTGRGQATHVEKKLAVFWVLAALQAIRETSDLKRVAELRNAAIPEAWKDAWVFIDHIPCPNVSCSGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LY48</accession>
    <name>A0AAJ0LY48_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dihydrofolate reductase</fullName>
            <ecNumber evidence="2">1.5.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_404037</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the dihydrofolate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.3" evidence="2"/>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717807.1">
        <property type="nucleotide sequence ID" value="XM_062865236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LY48"/>
    <dbReference type="GeneID" id="87884065"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004146">
        <property type="term" value="F:dihydrofolate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046452">
        <property type="term" value="P:dihydrofolate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046655">
        <property type="term" value="P:folic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00209">
        <property type="entry name" value="DHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="entry name" value="Dihydrofolate Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012259">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017925">
        <property type="entry name" value="DHFR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001796">
        <property type="entry name" value="DHFR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069:SF3">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00186">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00070">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="Dihydrofolate reductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00075">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51330">
        <property type="entry name" value="DHFR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHFR" evidence="9">
        <location>
            <begin position="30"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="73"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3302027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="266" mass="29053" checksum="D7F658F03847F7FA" modified="2024-07-24" version="1">MSHEFLQKTSSSSSSTAATGATQRGSPLPEVTLIVAATAQHMGIGRAGSLPWPMLKREMAYFARVTRRLPPPVVPLKSESGGGGVMNNDDDDDARRKKKKKNAVVMGRKTWESIPERFRPLPGRWNVVLSTRGATTTTPTTGGEGAAGGVPEAVTAQSLEEALAYLRDVKQKKEGGGLGRVFVIGGAQIYRAALEMIQARRVLLTRVRTDFECDTFFPLKLDEDGAPGWRRASQAEMDAWVGEEVPRGVQSEAGTEYEFEMWERVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LYB0</accession>
    <name>A0AAJ0LYB0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein AF-9 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_296348</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717987.1">
        <property type="nucleotide sequence ID" value="XM_062863769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LYB0"/>
    <dbReference type="GeneID" id="87882598"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16908">
        <property type="entry name" value="YEATS_Yaf9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1970">
        <property type="entry name" value="YEATS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038704">
        <property type="entry name" value="YEAST_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005033">
        <property type="entry name" value="YEATS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055129">
        <property type="entry name" value="YEATS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47573">
        <property type="entry name" value="PROTEIN AF-9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47573:SF1">
        <property type="entry name" value="PROTEIN AF-9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03366">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51037">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="YEATS" evidence="7">
        <location>
            <begin position="8"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="169"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="169"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51037"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="268" mass="30503" checksum="9FA9D8B7B7DD573E" modified="2024-07-24" version="1">MAPPTGKRVKGVQIFRPFVYGTTARPFDEKTNPKPPGIPDDHTHSWTVFVKGIDDVDITYWLRRVQFKLHESIPNHVRMIEGEKGKPFQIHETGWGEFEIAIKLYYVPESAEKPQTLYHHLRLHPYGRTEEEKESMRLNGGQVISWAYEEQIFNEPYEPFYEILTSGAMPPSSTSAASSRSGLKGGKGKDKEQGKQVARSEGGVLDRSAMIPLTNRPGQPFSRETEQLEIKKLKEALVKVEELTQKTKDEVQKKEQRLKELKAEAANG</sequence>
</entry>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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    </gene>
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        <name type="scientific">Chaetomium strumarium</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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        </lineage>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062863891.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87882720"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3302509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="94" mass="10623" checksum="BC11EF76611213A5" modified="2024-07-24" version="1">MLQILLANAGGKGSAAILLRLFWVLSNSRGSYWRATRKFIVPAEKANCPGLRRAEKKWRGNQQFNSAIRGVIVWFPSHRPSTYLHITMSPSLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LYN8</accession>
    <name>A0AAJ0LYN8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_543149</name>
    </gene>
    <organism evidence="6 7">
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
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        </subcellularLocation>
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    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062869969.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87888798"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rhodanese-like domain"/>
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    </dbReference>
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        <property type="entry name" value="HD"/>
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        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="5">
        <location>
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            <end position="809"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="1">
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            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
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        </location>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3302525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LYS0</accession>
    <name>A0AAJ0LYS0_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Transferase family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_422787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718395.1">
        <property type="nucleotide sequence ID" value="XM_062865577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LYS0"/>
    <dbReference type="GeneID" id="87884406"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050317">
        <property type="entry name" value="Plant_Fungal_Acyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642:SF310">
        <property type="entry name" value="FATTY ALCOHOL:CAFFEOYL-COA ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3302615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="482" mass="52620" checksum="A216D04910FD9215" modified="2024-07-24" version="1">MPTSTLRTAELSLLDQYMPRIYITLFLVFETSDPSGAVDSLKAGLKRLNRRLPNLKGRVFSTDGGRVGLRWSPTAKDVELHEVPTNGLILSGTSFTKLKTEGVPLHYFPPCLSPLLRLSNVRSDSGEPVFAANYTLLDGGLVVGLSVHHSVMDGTGVVELIRFWAACTRSDAIDAATPAPDPDEPLRRDILLRLATGHATQTRPTLFHDLLARHPEFALLSDATPAPPLPSPKGTSKLFTFDTFKLDRAKTALRALKTPLEAKWITTNSILCAAIWSCITRVRAARRGQEGFGAGAAASSKLGFAINGRTKLDRTSELSERPFLGNVTLYGLAGASVSHLERASSSSVATGERAELVVEAIGDAIKRVTPVYVAEVMELIGRAPDVEKIMPGWNSFDGPDLMLTSWMNMGLYEADFGQGIGKPRFMRVPQMEVDGFVIVLPRKRELAHAEIGRKECIEVVVAMHPEDMAALNREVLWRDLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LYU4</accession>
    <name>A0AAJ0LYU4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-lactamase/transpeptidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_423029</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718527.1">
        <property type="nucleotide sequence ID" value="XM_062865584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LYU4"/>
    <dbReference type="GeneID" id="87884413"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058664">
        <property type="entry name" value="ARB_00930-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051478">
        <property type="entry name" value="Beta-lactamase-like_AB/R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22935:SF97">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22935">
        <property type="entry name" value="PENICILLIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26335">
        <property type="entry name" value="ARB_00930_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042480896" evidence="1">
        <location>
            <begin position="23"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-related" evidence="2">
        <location>
            <begin position="99"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-like ARB-00930-like C-terminal" evidence="3">
        <location>
            <begin position="426"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3302747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="577" mass="62131" checksum="73323C059D63BD2A" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LYW7</accession>
    <name>A0AAJ0LYW7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP adenylyltransferase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_497158</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718483.1">
        <property type="nucleotide sequence ID" value="XM_062867244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LYW7"/>
    <dbReference type="GeneID" id="87886073"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003877">
        <property type="term" value="F:ATP:ADP adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009163">
        <property type="entry name" value="Ap4A_phos1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043171">
        <property type="entry name" value="Ap4A_phos1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045759">
        <property type="entry name" value="Ap4A_phos1/2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019200">
        <property type="entry name" value="ATP_adenylylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420">
        <property type="entry name" value="AP-4-A PHOSPHORYLASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19327">
        <property type="entry name" value="Ap4A_phos_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09830">
        <property type="entry name" value="ATP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ap4A phosphorylase 1/2 N-terminal" evidence="3">
        <location>
            <begin position="33"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="ATP adenylyltransferase C-terminal" evidence="2">
        <location>
            <begin position="198"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3302703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="315" mass="34857" checksum="ACD9C9095AE487FE" modified="2024-07-24" version="1">METELNESRLLAQFDSLVEQGSVVYNGNYRTVTVSDNGFPIEFRILDGLQKKPQLSDTPHDSEKRSSPEEQAPSGCRPGSDIDTTGYEVATLGSTHLLAINKFPAARPHLLILTQDGFRRQHEALDLSDLTAARQVLASLESRHLLLFNCGIDSGCSRMHKHMQAFPAPDPKDFPLWPDEEEAKLANAQVQQVVKPTFKFFLHRFADDGLPPPDTLLGIYRGLVRRAEREAAGYVVAREEGGEGEQVAVVAHNVIMDRSWLLVVPRRAAGWDGVDTNAAGMLGMVWVHSEEKMKLWMERGPGNVLARLGIPADGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZ66</accession>
    <name>A0AAJ0LZ66_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">Phosphatidylinositol transfer protein SFH5</fullName>
            <shortName evidence="16">PITP SFH5</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B0T15DRAFT_438186</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Non-classical phosphatidylinositol (PtdIns) transfer protein (PITP), which exhibits PtdIns-binding/transfer activity in the absence of detectable PtdCho-binding/transfer activity. Regulates PtdIns(4,5)P2 homeostasis at the plasma membrane. Heme-binding protein that may play a role in organic oxidant-induced stress responses.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(out)</text>
            <dbReference type="Rhea" id="RHEA:38691"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:38692"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 16">Endoplasmic reticulum membrane</location>
            <topology evidence="2 16">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Microsome membrane</location>
            <topology evidence="16">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the SFH5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718830.1">
        <property type="nucleotide sequence ID" value="XM_062865863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZ66"/>
    <dbReference type="GeneID" id="87884692"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017157">
        <property type="term" value="P:regulation of exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042938">
        <property type="entry name" value="Sfh5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47669">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN SFH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47669:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN SFH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12 16" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 16" id="KW-0492">Microsome</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="18">
        <location>
            <begin position="199"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="323"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="23"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00024180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU367059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAK3303050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="348" mass="38010" checksum="B1C628BF69E9C166" modified="2024-07-24" version="1">MSTTEQQPEVVPAADAPDVSKTAADATKPEVVAAAAPASTAADTAAAPAPTEAITEATAPTPSETKESTEKKEPAIESTPIGQLWTLVKAFGHPEIWGVTLVDPADHVPTRIILQKYLNANDGDLAKAKEQLTKTLEWRAKTKPLELAGKVFSKAKFDGLGYVTKYAQEGSDEPEGKEVFTWNIYGGVKSMNETFGKLEEFLEWRVALMELALQELDISSATKPITAEYDPYKIYQVHDYKSISFLRQSPQVKAASTETIKVFAQNYPELLKEKFFVNVPAVMGFIYTFMKLFVAPKTIKKFHPMSNGGNLAREFGESKVSELGDKLPDSYGGKGGKLEEQGKGPLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZB9</accession>
    <name>A0AAJ0LZB9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_513420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718995.1">
        <property type="nucleotide sequence ID" value="XM_062868035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZB9"/>
    <dbReference type="GeneID" id="87886864"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3303215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="116" mass="12657" checksum="2CD7C4FC2C0C7C90" modified="2024-07-24" version="1">MFSRNHSNLEVILSETEDRDATNNSKSGSSKTQTMNLATLQHLLAQDDLDEDQFLNRIWIGLLGVEALIVLGVALHGLVGAASSSRLLARRRRSSAGIEWGSMSPAKVERGLWPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZH7</accession>
    <name>A0AAJ0LZH7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_560493</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719232.1">
        <property type="nucleotide sequence ID" value="XM_062870531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZH7"/>
    <dbReference type="GeneID" id="87889360"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12339">
        <property type="entry name" value="RRM2_SRSF1_4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF51">
        <property type="entry name" value="SERINE-ARGININE PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="7"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="104"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="79"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="173"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="214"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="244"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="260"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="283"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3303452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="313" mass="36372" checksum="60BB963F97D3D7F8" modified="2024-07-24" version="1">MTEVSSTRLYLGNLPRHATKADVEAHFATHGTGEITEIKLMNGFGFIEYKDAMDARDVVPAFHGSDFMGERLTVQFARGTRHREQGSGYNHDRGSAPRPRRTPHRMQITGLPNDTSWQDLKDFARQSGLDVVYSETNRNGGNEGFVEFETAADLRTAVEKLDGREFKNSRVTCVANTQPDIPRIDRARSRSPRRPYPPPIDDYDRRGPPRGYSPRRDGYRDGYRERTPPPRRDYYDDRRGGYRSPPPRRPPIDDYPPPRGRYDDPYRGPRDYPPDPYMNGRAPYHDRRPPPPDFPPRDPYAREPYPRDYDRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZQ7</accession>
    <name>A0AAJ0LZQ7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_487033</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719472.1">
        <property type="nucleotide sequence ID" value="XM_062866405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZQ7"/>
    <dbReference type="GeneID" id="87885234"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF26">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="310"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="16"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3303692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="535" mass="59597" checksum="D50CC043C3226722" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZZ2</accession>
    <name>A0AAJ0LZZ2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_223805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3303904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719684.1">
        <property type="nucleotide sequence ID" value="XM_062862845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZZ2"/>
    <dbReference type="GeneID" id="87881674"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3303904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="251" mass="27476" checksum="ED157128859DCE84" modified="2024-07-24" version="1">MMRTTVAAPPILLRVVAQVQCCPSLARQLTVYLGLKHRKARVPRLRKSSEDERLETRSDDALVSAPSSPRSPEFPPKCLGQQDSAGTVFKDPSVKIRLVALRSSILDSTFIQINTTEGSAHGIGIPPYRNEAIPLESYQEQVETSTTRDDCVTLLTQNGFNSGALSGTPSFIRLPGSRHFKRSTLLWWTSLWRRGTAEVGSKFSTTRKLLGHVVAGSPTTGLTFVTPAARVRVFAKALLALSTRSSAVKTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M010</accession>
    <name>A0AAJ0M010_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chaperonin 10-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_435873</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3303873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719653.1">
        <property type="nucleotide sequence ID" value="XM_062865822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M010"/>
    <dbReference type="GeneID" id="87884651"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="20"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3303873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="345" mass="36092" checksum="406A5D5D6DC7FD4D" modified="2024-07-24" version="1">MVSQNEGDSQIRQYVATQKGGPFAVTHAPYPTPGPNELCIRNVAVGLNPLDWKNLYHGEMVKAWPEIFGIDTAGIVVAVGENVTAFKPGDAVMSLSGHGGRAGAFQDVTTVPANFATRKPVDWTFEEACSVPICYLTAAAAVAKGLGVSLFQDQAASNALPLNSILVLGGSSGVGASAVQLLRAALPHAAILTTNSRKHNVHVLSLGATACIDRNEPDIVAAIRAASPTGQGVDAILDAVAGVPDNGQLFETLRSDGPRLYSQVFTGTHQLAIPERVSAQTVFGRMVFQMPGGFWAMEKLSEMVSRGQFKLPLRVVVVGKGLEAIGSGLEILRAGVSGTKLVVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M064</accession>
    <name>A0AAJ0M064_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_399695</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="6"/>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719818.1">
        <property type="nucleotide sequence ID" value="XM_062865023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M064"/>
    <dbReference type="GeneID" id="87883852"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033096">
        <property type="entry name" value="PPPtase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="8">
        <location>
            <begin position="203"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="97"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR033096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3304038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="401" mass="44141" checksum="0147F1B22F80CD4D" modified="2024-07-24" version="1">MATVPKPGPANLRPGAGLDEWLEEAKQCHYLPEPVMKQLCEMVKEVLMEESNIQPVVTPVTICGDIHGQFYDLLEMFRVAGGMPGESNVQAPMTSTTVITSDDIEPPSEITNPKLKSKVKNAESPGEGDAGGDDNDDDAATEAQQQEANTSTHSPPPADSGVQSADTRFVFLGDFVDRGYFSLETFTLLMCLKAKYPDRIVLVRGNHESRQITRVYGFYEECQQKYGNASVWKACCQVFDFLVLAAIVDGTVLCVHGGLSPEIRTIDQIRVVARAQEIPHEGAFCDLVWSDPEDIDTWAVSPRGAGWLFGHKVATEFNHVNGLKTIARAHQLVNEGYKFHFPEKSVVTVWSAPNYCYRCGNVASIMTVDSCLNTKFSIFSAVPDDQRHIPGGRRGAGDYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M0D8</accession>
    <name>A0AAJ0M0D8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ctf8-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_238791</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CTF8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720147.1">
        <property type="nucleotide sequence ID" value="XM_062863043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M0D8"/>
    <dbReference type="GeneID" id="87881872"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018607">
        <property type="entry name" value="Ctf8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28605:SF1">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28605">
        <property type="entry name" value="CTF8, CHROMOSOME TRANSMISSION FIDELITY FACTOR 8 HOMOLOG (S. CEREVISIAE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09696">
        <property type="entry name" value="Ctf8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="52"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3304367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="163" mass="17758" checksum="F949771C9EBAD909" modified="2024-07-24" version="1">MSEAATQTVVPLHPPSSSPSSSSPFANPLPALLHTPSGLALLELQGTINLPPSVLHEPSSESDDASEAPPVPIGRLHFPEYHPGTKDDTAWMKRVWMYVGNHQRMLGEVKKLPRALAVLRRRSDPRVVEGEGEKKEEELEVVEVVKYKIVFSSRPEPVGGGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M183</accession>
    <name>A0AAJ0M183_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_511201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721050.1">
        <property type="nucleotide sequence ID" value="XM_062867899.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87886728"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3305270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="345" mass="36871" checksum="09EEC1718DF291BB" modified="2024-07-24" version="1">MANEARSTLNRETRGPEVSALADAYLADLDLPQYGMVKEVFLKAYEMGYLAGLAKALRQARQVSREGDEAGCREAQAEFEVEESVDENEEDSENDDWSGDVVSAWVETMSPVRQRNPFFRYARSTIPRAHLAALAAVEPGEIADVETGSRAALVAPTPSSSPPAAAVRELSDLEPRLPAVLADVSAGDSAAAAAATTAPAATTTTTTTAATPTTAPAATTSAGQRDSLYGIPLAYTIVPIDVQALRKKGPTVAENPYRVVIGPVSDAAREAWKGDRGKAYLHKKLGGDRRSGLHLCQMLRAHDGTFYVLAMFASQQYASKTVELMGRGYPCGGSIMWAWTCPEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M1I3</accession>
    <name>A0AAJ0M1I3_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_532530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721287.1">
        <property type="nucleotide sequence ID" value="XM_062869316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M1I3"/>
    <dbReference type="GeneID" id="87888145"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3305507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="455" mass="49541" checksum="8BFB978F2D72ABF0" modified="2024-07-24" version="1">MCQAPSVEAVRSLLGPVITADVSVRKVQAVSSLGPRRTYRVVLSDGRSLQLVLLSRALWRPLRSEQDMVASEAAAVRWMREAVADRSPADSDLSAFLLPLLPVLLHQGQETDFPGASFAVHDPVEGTPLALLPQPPTPASLADVDHQVGTLVRQLARLTSPTGRFGPLAAVIGSRSTPSPLSKTGAEVAAAANMLEGGLSATGGAGTWSMAFHSMLEGVLRDGEDMGIVMGYWTIRKTFRRLRYILDEVTVPRLVAVEVGGKGNVLVEEAVPADGAKGGKGRGEAVPEPEDEEKIQKAEQQTETEETERDAPRRLKLTGLRDWSSCVFGDPLLATLFSDRQQHPPSTDFLRGFNGKGIEHTPTRERPIPLDGSIIEDVGTAWIRLLLYQVYHAVVRIVSEFYRPRQDSSARELAARKELNEALARLAEVPDDAKKKHQRPSGEMSPAKRIKADER</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M1X6</accession>
    <name>A0AAJ0M1X6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_485463</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721766.1">
        <property type="nucleotide sequence ID" value="XM_062866291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M1X6"/>
    <dbReference type="GeneID" id="87885120"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042493088" description="Peptidase A1 domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="429"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3305986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="545" mass="58606" checksum="3A828E6396725E43" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M2E9</accession>
    <name>A0AAJ0M2E9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Oxysterol-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_222716</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3306244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722024.1">
        <property type="nucleotide sequence ID" value="XM_062862831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M2E9"/>
    <dbReference type="GeneID" id="87881660"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008142">
        <property type="term" value="F:oxysterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF92">
        <property type="entry name" value="OXYSTEROL BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="88"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="89"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3306244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="423" mass="47327" checksum="1928DECD0B82447E" modified="2024-07-24" version="1">MDSRSLHSRLRELVKFLGTVKGDLANVTGPPSLLAPCSVVEVGHCWAERPAVFAAPALEPSPEKRALLVLRWFLMALRSQLYIGVDHYPTPTTSTSTTSTDGTTTSSSSPPSQTKSIRKPLNAFLGELFLARWADAERKCTIDLVAEQVSHHPPITAMHVADRAHGVRADGYARVEMTFNGSVNIRQVGHATLHVDRYDEDHLVPLPDVKVRGFLSGCLYPEIAGTYQLVSSAGFVTECRFWGEGLIRGKRNSFEARVYRREDKRRKEPLFEVAGCWSEGWTVRDCSSDEVLEVVDLDAPENEPVPMDIAPLEAQDPWESRRAWAGVLHGLRVGDMRTVVAEKTKVEQAQRQMRASEARRGVAWEPLLFRSVPGESHEVFHRLSEGMGWQLHHDRTKGVWKINDGRVKTLERPFRAGATPFGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M2K6</accession>
    <name>A0AAJ0M2K6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_394967</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat ESC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722398.1">
        <property type="nucleotide sequence ID" value="XM_062864757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M2K6"/>
    <dbReference type="GeneID" id="87883586"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051243">
        <property type="entry name" value="PcG_WD-repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10253">
        <property type="entry name" value="POLYCOMB PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="132"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="181"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="421"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3306618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="521" mass="57428" checksum="9731E3F8C529B186" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M2L0</accession>
    <name>A0AAJ0M2L0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hemerythrin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_573673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722520.1">
        <property type="nucleotide sequence ID" value="XM_062870934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M2L0"/>
    <dbReference type="GeneID" id="87889763"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35585">
        <property type="entry name" value="HHE DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G00730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35585:SF1">
        <property type="entry name" value="HHE DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G00730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin-like" evidence="1">
        <location>
            <begin position="3"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3306740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="174" mass="19710" checksum="3819394F676A6E41" modified="2024-07-24" version="1">MSTISEVITKDHRELEQYYNEVVNSSDHDHQERFGNQFTWELARHSVAEELIVYPAFEKHMGSKGHEMAESDRKDHHRLKELWGVLSAHIKEEEVHDLPALETALQSAGAGESENMAKKFGRTKALVPSRSHPSAGENKYFESAMGMLAAPIDHIADIFRKFPDETISPNPSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M2T6</accession>
    <name>A0AAJ0M2T6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 12">Cysteine dioxygenase</fullName>
            <ecNumber evidence="3 12">1.13.11.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0T15DRAFT_573768</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>L-cysteine + O2 = 3-sulfino-L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20441"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:61085"/>
            <dbReference type="EC" id="1.13.11.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="12">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the cysteine dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.20" evidence="3 12"/>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722638.1">
        <property type="nucleotide sequence ID" value="XM_062870936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M2T6"/>
    <dbReference type="GeneID" id="87889765"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017172">
        <property type="term" value="F:cysteine dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019448">
        <property type="term" value="P:L-cysteine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10548">
        <property type="entry name" value="cupin_CDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000189">
        <property type="entry name" value="Cysteine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010300">
        <property type="entry name" value="CDO_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12918">
        <property type="entry name" value="CYSTEINE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12918:SF1">
        <property type="entry name" value="CYSTEINE DIOXYGENASE TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05995">
        <property type="entry name" value="CDO_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8 11 12" id="KW-0408">Iron</keyword>
    <keyword evidence="4 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0883">Thioether bond</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="cross-link" description="3'-(S-cysteinyl)-tyrosine (Cys-Tyr)" evidence="10">
        <location>
            <begin position="116"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR610300-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR610300-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3306858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="216" mass="24034" checksum="801E3881166B924F" modified="2024-07-24" version="1">MAVGIVESSLSQYQATFPCRINADNNRFDDLVLALKDALGPCSGLTSDDVDVEHLTRLMREYDSDPREWSKYAMGDESRGYTRNLVDEGNGKSNLLVLVWSPGKGSPIHDHGNAHCLMKILRGNLTETRYAFPENKAEAPMRVISEKVHQENEVAYMADELGVHRVRNQGSDFAVSLHLYTPPNVAKGGCHIFNAETGKKSHIKNCGYYSAYGKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M2W0</accession>
    <name>A0AAJ0M2W0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lysophospholipase</fullName>
            <ecNumber evidence="6">3.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_395912</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the lysophospholipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="6"/>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722846.1">
        <property type="nucleotide sequence ID" value="XM_062864802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M2W0"/>
    <dbReference type="GeneID" id="87883631"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00147">
        <property type="entry name" value="cPLA2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002642">
        <property type="entry name" value="LysoPLipase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728">
        <property type="entry name" value="CYTOSOLIC PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728:SF40">
        <property type="entry name" value="PATATIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01735">
        <property type="entry name" value="PLA2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00022">
        <property type="entry name" value="PLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51210">
        <property type="entry name" value="PLA2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 5 6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PLA2c" evidence="9">
        <location>
            <begin position="184"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="616"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="785"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="637"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="669"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3307066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="827" mass="92142" checksum="07FA7325B4C03959" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M301</accession>
    <name>A0AAJ0M301_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_510488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722966.1">
        <property type="nucleotide sequence ID" value="XM_062867855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M301"/>
    <dbReference type="GeneID" id="87886684"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3307186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="238" mass="27210" checksum="D84EC9E017AEB678" modified="2024-07-24" version="1">MPVWETAAGSLAPASTQFLSDSQRRQFSVTYGPPTPAENVEETEDICIAQLRKHVDHLRPGVYGIRFSEPDGPVTISTPARDDVKGVIFTLYEIITPGRAFPGDVKLDSDIEAFRAVLDAWVKKRRRMMEYQPAESWIRWPFMREPPPARVPRFVPDGEITKIETENSTIRVRQHLVRMGEPFWKWERPASYQTAEAPGNGYTCHCQDDSEEGLAKKREEPSRKQEGLLRKQRGQAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M317</accession>
    <name>A0AAJ0M317_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_394737</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723000.1">
        <property type="nucleotide sequence ID" value="XM_062864746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M317"/>
    <dbReference type="GeneID" id="87883575"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097237">
        <property type="term" value="P:cellular response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050097">
        <property type="entry name" value="Ferredoxin-NADP_redctase_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48105">
        <property type="entry name" value="THIOREDOXIN REDUCTASE 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="4">
        <location>
            <begin position="6"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3307220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="326" mass="34765" checksum="1092661DDA7A2398" modified="2024-07-24" version="1">MPPNLKDVLIIGGGPSGLAAATSLARQLYTAVVFDSGVYRNARTRHMHNVPTWDHRDPGEFRAKARADLLARYHTIHFEDTAVESVRRTEDGRFEATDAKGTTWTGKKVVLASGVRDIYPDVPGYDDVWGRGVYHCLFCDGYEDRGAASAGVLAIGDLGPASPASFPAAAALAFPALHVARMAKRLAKKVVVYTNGAPEFAKEIAAALGSDPVIVVDDRRVTRLQKANEESSEVIVHLEDGTTVSHGFMAHKPKTQVNGPFAEQLGVEFTEMGFIKTTPPFYETIVPGVFAIGDCATAMPAVVNALGMGAFAAGGIASQLGKEPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M3E7</accession>
    <name>A0AAJ0M3E7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Inner centromere protein ARK-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_414955</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the INCENP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723401.1">
        <property type="nucleotide sequence ID" value="XM_062865452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M3E7"/>
    <dbReference type="GeneID" id="87884281"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005635">
        <property type="entry name" value="Inner_centromere_prot_ARK-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13142">
        <property type="entry name" value="INNER CENTROMERE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13142:SF1">
        <property type="entry name" value="INNER CENTROMERE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03941">
        <property type="entry name" value="INCENP_ARK-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1079"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="120"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="200"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="242"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="276"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="289"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="313"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="336"/>
            <end position="359"/>
        </location>
    </feature>
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        <location>
            <begin position="430"/>
            <end position="441"/>
        </location>
    </feature>
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        <location>
            <begin position="443"/>
            <end position="456"/>
        </location>
    </feature>
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        <location>
            <begin position="457"/>
            <end position="504"/>
        </location>
    </feature>
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        <location>
            <begin position="607"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="624"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="737"/>
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        </location>
    </feature>
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        <location>
            <begin position="796"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="1081"/>
            <end position="1090"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3307621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1187" mass="130011" checksum="89E128231BA8E1A5" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M452</accession>
    <name>A0AAJ0M452_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_390570</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724107.1">
        <property type="nucleotide sequence ID" value="XM_062864548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M452"/>
    <dbReference type="GeneID" id="87883377"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF7">
        <property type="entry name" value="NADB-LER2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3308327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="162" mass="17305" checksum="0B2249152A9DC140" modified="2024-07-24" version="1" fragment="single">ANAGGLRVVIAPLESVTADDLIETFQVNALGPLLLFQAIRPLLQKSTAAPKWISISSAIGSIGFMPNYHSHYAPAYGISKAALNWITMAAHCGNPWLVAFCVNPGLTQSEPGNRNAQLLGMEKAPITLQQAADAIISFVDKAAREATSSKFFQVVTGQEIPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M477</accession>
    <name>A0AAJ0M477_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_550413</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724153.1">
        <property type="nucleotide sequence ID" value="XM_062870248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M477"/>
    <dbReference type="GeneID" id="87889077"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3308373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="183" mass="19839" checksum="2739CFE97CD33293" modified="2024-07-24" version="1" fragment="single">LWRGQPDRTLHVKDVNDLYSQVLALNRDWIADLANPDQTLHDYGPRVCGADSGIATGDSEKLSLQLTKLRQLAGSWILDAGTCHRLGCGTNAGVYWCNDNAWNIRASAKSLYLRGSHVRDGCCHRTDGSLFGGDPMSGVEAFPDQHKEAAHSRVAVGYGNCEDPVDVVPLVYSFPGKLGVCLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M4U1</accession>
    <name>A0AAJ0M4U1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mis12-Mtw1 protein family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_128810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3309078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724858.1">
        <property type="nucleotide sequence ID" value="XM_062861726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M4U1"/>
    <dbReference type="GeneID" id="87880555"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013218">
        <property type="entry name" value="Dsn1/Mis13"/>
    </dbReference>
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        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN DSN1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14778:SF2">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN DSN1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MIS13"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="404"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="134"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="225"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3309078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="564" mass="61889" checksum="20493E8AF939D598" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M557</accession>
    <name>A0AAJ0M557_9PEZI</name>
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        <submittedName>
            <fullName evidence="6">FAD-linked oxidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_387372</name>
    </gene>
    <organism evidence="6 7">
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        <lineage>
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    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_062864381.1"/>
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    <dbReference type="GeneID" id="87883210"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:D-lactate dehydrogenase (NAD+) activity"/>
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    </dbReference>
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        <property type="term" value="P:lactate catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
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        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
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        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
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    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748:SF114">
        <property type="entry name" value="ARYL-ALCOHOL OXIDASE VANILLYL-ALCOHOL OXIDASE (AFU_ORTHOLOGUE AFUA_3G09500)-RELATED"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        </source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
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    </gene>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725129.1">
        <property type="nucleotide sequence ID" value="XM_062861371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M587"/>
    <dbReference type="GeneID" id="87880200"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045035">
        <property type="entry name" value="YSL-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645:SF3">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER YGL114W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="300"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="451"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="478"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="637"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="676"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="711"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3309349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="753" mass="81133" checksum="54C03852D0398036" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M5B6</accession>
    <name>A0AAJ0M5B6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_515495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725220.1">
        <property type="nucleotide sequence ID" value="XM_062868198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M5B6"/>
    <dbReference type="GeneID" id="87887027"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3309440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="237" mass="24652" checksum="A4C786A94DB55E72" modified="2024-07-24" version="1">MEIAPYEGIEVFNGWGPEAINGGQHQKFHRAADSSGVLSPKSRLCGLSRTIFWLAITITVLAIIIIGLATGFGVALSKAQNANAYNSMPSSLASTTPTVFSSPPSSSTHISPALTPLSTSTVSSTSMSGGIPQPSNICPGANNTILTPPIGDVRYLVACDSDFGDSGKQTLASFVTATWDDCLDLCNTMNYFQDRADIGCTWNVLGTGTQTPGTCWCLGGADKTVVANRGNVAAVPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M6J3</accession>
    <name>A0AAJ0M6J3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_44780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726432.1">
        <property type="nucleotide sequence ID" value="XM_062865953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M6J3"/>
    <dbReference type="GeneID" id="87884782"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042459986" description="Secreted protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3310652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="89" mass="10033" checksum="ABB3067D9C8A4F2B" modified="2024-07-24" version="1">MHRHQRRALTCMIGPLWVLLCGCSQCTEPTVTLQTFGQPRSVIPQKMLGSQYGTDEIATRHSIICATWSSMSIGLYRGVGHLWMTSRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M6V2</accession>
    <name>A0AAJ0M6V2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_489873</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727033.1">
        <property type="nucleotide sequence ID" value="XM_062866637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M6V2"/>
    <dbReference type="GeneID" id="87885466"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="6">
        <location>
            <begin position="97"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3311253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="606" mass="64908" checksum="E5F582ED563A44AA" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M7B0</accession>
    <name>A0AAJ0M7B0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ADF-H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_83295</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the actin-binding proteins ADF family. Coactosin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727483.1">
        <property type="nucleotide sequence ID" value="XM_062871367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M7B0"/>
    <dbReference type="GeneID" id="87890196"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11282">
        <property type="entry name" value="ADF_coactosin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000018">
        <property type="entry name" value="Coactosin-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829:SF56">
        <property type="entry name" value="ADF-H DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829">
        <property type="entry name" value="CORTACTIN AND DREBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="6">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3311703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="146" mass="15598" checksum="255ADBC08B218ECE" modified="2024-07-24" version="1">MSGADSPEILAAYDAVRSDKDATNWLLISYAAPTGNALTLSKTGTGGLAELAASLDDGEVQYAYVRVEYANDAESKRVKFAFVVWIGPNTKVMRKARAGLEAGAVKKVLSHYSVQVDAGERRDLDEQEVVSRLRKAGGADYNGGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GKE3</accession>
    <name>A0AAJ0GKE3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">S-formylglutathione hydrolase</fullName>
            <ecNumber evidence="2 7">3.1.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_316354</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Serine hydrolase involved in the detoxification of formaldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>S-formylglutathione + H2O = formate + glutathione + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14961"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="EC" id="3.1.2.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the esterase D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.12" evidence="2 7"/>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717350.1">
        <property type="nucleotide sequence ID" value="XM_062863995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GKE3"/>
    <dbReference type="GeneID" id="87882824"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018738">
        <property type="term" value="F:S-formylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000002">
        <property type="entry name" value="S-formylglutathione hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014186">
        <property type="entry name" value="S-formylglutathione_hydrol"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02821">
        <property type="entry name" value="fghA_ester_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10061">
        <property type="entry name" value="S-FORMYLGLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10061:SF0">
        <property type="entry name" value="S-FORMYLGLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0719">Serine esterase</keyword>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR614186-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3301570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="295" mass="32400" checksum="03594517E3DAB060" modified="2024-07-24" version="1">MAFTTKATIASFGGKLFKLSHQSTTTGTPMAVNLYLPPQALSSQGNTRKVPLLIYLSGLTCTPENCSEKGFFQHRASQLGLAILYPDTSPRGLNLPGEKDAWDFGEGAGFYIDATQEPWKGGYRMESYITRELPATLFGDAEYGKYLDSERVSITGHSMGGHGALTLYLKNPAMYKSVSAFAPIANPSKCPWGEKAFSGYLGTENKEAEWKKHDATELVRGWKGGDLKALVDVGTGDNFYKQGQLLPENLEKAAEEAGVEGLTVRYQQDYDHSYYFMATFSDDHVNHAAKYLGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2025-04-02" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GKF9</accession>
    <name>A0AAJ0GKF9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nucleoporin NUP188</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0T15DRAFT_316779</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the Nup188 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717363.1">
        <property type="nucleotide sequence ID" value="XM_062864001.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87882830"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018864">
        <property type="entry name" value="Nucleoporin_Nup188_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044840">
        <property type="entry name" value="Nup188"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041634">
        <property type="entry name" value="Nup188_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048883">
        <property type="entry name" value="Nup188_N-subdom_III"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31431:SF1">
        <property type="entry name" value="NUCLEOPORIN NUP188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31431">
        <property type="entry name" value="NUCLEOPORIN NUP188 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18378">
        <property type="entry name" value="Nup188_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10487">
        <property type="entry name" value="Nup188_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21093">
        <property type="entry name" value="Nup188_N-subdom_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21094">
        <property type="entry name" value="Nup188_SH3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup188 N-terminal" evidence="10">
        <location>
            <begin position="178"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup188 N-terminal subdomain III" evidence="12">
        <location>
            <begin position="705"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="domain" description="Nuclear pore protein Nup188 C-terminal" evidence="11">
        <location>
            <begin position="1453"/>
            <end position="1815"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF21093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3301583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1821" mass="201754" checksum="D322C2E152169FD0" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GKR0</accession>
    <name>A0AAJ0GKR0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_321335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717472.1">
        <property type="nucleotide sequence ID" value="XM_062864057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GKR0"/>
    <dbReference type="GeneID" id="87882886"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025340">
        <property type="entry name" value="DUF4246"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049192">
        <property type="entry name" value="DUF4246_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049207">
        <property type="entry name" value="DUF4246_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33119:SF1">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33119">
        <property type="entry name" value="IFI3P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14033">
        <property type="entry name" value="DUF4246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21666">
        <property type="entry name" value="DUF4246_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4246" evidence="2">
        <location>
            <begin position="10"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4246" evidence="1">
        <location>
            <begin position="117"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3301692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="696" mass="79748" checksum="4CD22D41B0DE1EF1" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GKY7</accession>
    <name>A0AAJ0GKY7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_404847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717633.1">
        <property type="nucleotide sequence ID" value="XM_062865269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GKY7"/>
    <dbReference type="GeneID" id="87884098"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042515950" description="Small secreted protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3301853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="153" mass="15887" checksum="EAC442D70C6B2C3C" modified="2024-07-24" version="1">MHFSNLLVGLAATASTAFAAPSSNINARADAVSAMAAVPQWTIKSFTRTCDAADTKCTVSFGIDTGSGAAATQCQYDATGAPASRTATNGVTCGPYTLSSSWSGQFGEGNGFTTWSVVDWSKRLIVWPAYTDKELVNGKAVTPDKSYAPQTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2025-04-02" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GLI9</accession>
    <name>A0AAJ0GLI9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">U3 small nucleolar RNA-associated protein 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0T15DRAFT_542141</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in ribosome biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Component of the ribosomal small subunit (SSU) processome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
            <location evidence="1 11">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the HEATR1/UTP10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717946.1">
        <property type="nucleotide sequence ID" value="XM_062869911.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87888740"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034455">
        <property type="term" value="C:t-UTP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012954">
        <property type="entry name" value="BP28_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056473">
        <property type="entry name" value="HEAT_Utp10/HEAT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022125">
        <property type="entry name" value="U3snoRNP10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040191">
        <property type="entry name" value="UTP10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457">
        <property type="entry name" value="BAP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457:SF1">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08146">
        <property type="entry name" value="BP28CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23243">
        <property type="entry name" value="HEAT_HEATR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12397">
        <property type="entry name" value="U3snoRNP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01036">
        <property type="entry name" value="BP28CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 11" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="6 11" id="KW-0698">rRNA processing</keyword>
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            <end position="629"/>
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        <source>
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</entry>
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                <person name="Andreopoulos B."/>
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                <person name="Chen C."/>
                <person name="Yan M."/>
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                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
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                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
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                <person name="Powell A.J."/>
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                <person name="Grigoriev I.V."/>
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        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
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                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
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                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
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                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
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                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
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        <source>
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        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Kuo A."/>
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                <person name="Riley R."/>
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    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <person name="Cros-Aarteil S."/>
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                <person name="Kuo A."/>
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                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
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                <person name="Chen C."/>
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                <person name="Ng V."/>
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                <person name="Ament-Velasquez S.L."/>
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                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GeneID" id="87886034"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="KAK3302288.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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    </evidence>
    <sequence length="375" mass="41820" checksum="EB7D0B3E44590506" modified="2024-07-24" version="1">MSALTSSPHPIPRFEQHVGFDNLPVGEATKNNPSSFTLQARHQGYHPSRRSRTFMIGIDEHAYSDYALVWLLTNMVDDGDEVVCVRVLEGPLRPEKNYQEDARKLLEEIQAKNELNRAISIVLEYSVGKLHDTFRQLLGIYNPSMLVVGTKGRSLGGIQGLMNTRNSFSKYCLQYSPIPVVVVRPDDKRLKKKEKRSQDPARQSYATMLAYNSGKHEADSDAGSVYEFLKSISEDEEAHRVAAAIGLPAAFDPTIKPYTPRDSTRRRSSPSTFASATSGRAASSSPPLTPLRGESGDEESGDEEDEFEVEAVSARQDVPDEREETKLERQRKERLHAMEVCEAAALLKSGKSKEPEDDEEDDESQERGAEDVSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <organism evidence="2 3">
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        <lineage>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
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                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
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                <person name="Chen C."/>
                <person name="Yan M."/>
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                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
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                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Labutti K."/>
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                <person name="Chen C."/>
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                <person name="Gladieux P."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
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        <text evidence="1">Belongs to the CDC123 family.</text>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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</entry>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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            <dbReference type="PubMed" id="37820761"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
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                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
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                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
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                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
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    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
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        <source>
            <dbReference type="EMBL" id="KAK3302814.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1215" mass="129930" checksum="94D551462769114D" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3302847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718627.1">
        <property type="nucleotide sequence ID" value="XM_062863271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GMT4"/>
    <dbReference type="GeneID" id="87882100"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3302847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="213" mass="22898" checksum="7CE16B3F64485DD5" modified="2024-07-24" version="1">MGNSNCCRHHGPVQLAGGRQMEYVYLWRCRPTSMRSPAVRSVAGVLTWPASPVVADSGRFGNPVGAADISRNSSASSWTPPTTTLTPWTAAPSPTGSVLLRRVRPAIWILDAIRGGKAKMLDIESSSPRRLPEQVPSRSPTPARSASTSGCPAGPKKILRQGPLSRLQTPNAPTWEGGWSGGVRRLVSGVWRLGFGFRRLASGVWSLEFGVWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ0GN15_9PEZI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_504288</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718788.1">
        <property type="nucleotide sequence ID" value="XM_062867494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GN15"/>
    <dbReference type="GeneID" id="87886323"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3303008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="307" mass="30970" checksum="5165AABE5F152201" modified="2024-07-24" version="1">MTPVGEGPDVSVIVVRLGNVVGTEGTTIGVLLAWELLGTVEFPDAVPVGSRVLQDRLHVKTLDFVALRPALTDVGAVGAVVSVTLPAADDVTPDGVKVVMLTNVEGATVGSNGLLVVLRSEVGRPGAVVRLVWSTGRDVIVVVKVRVMMTGGGDAVPVIETKTELSSLVGVAVVFLGVVLFALVGRGPEGNVTVVLVTLENTIEEGAGAPVPGTAGVVEFAKPDDRPAPLVGSSLSMVEYVGAGVVDTPVCDSEAESDVEFPGGARLGTVEPGSGSEVVDSIPDCVTVVFGAGTADVYEVGIVDGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GN39</accession>
    <name>A0AAJ0GN39_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_504291</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718792.1">
        <property type="nucleotide sequence ID" value="XM_062867495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GN39"/>
    <dbReference type="GeneID" id="87886324"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042551573" evidence="3">
        <location>
            <begin position="22"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3303012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="243" mass="23202" checksum="919A488F60DF3E10" modified="2024-07-24" version="1">MRCQLALSGALAGLLAQVATATTCTPDNATPVESLVSSGGGGSGGGGADIFVSYNPFDVISNAVKKRTTPDARLGNMANILVVSRRDSASSVTCAATEMCLSIQKYPFCLDLTNGDFHDGTGITGNALSGDYTLADGRKGNLYNGPYPQPTGAGGASAPATTAAAASAAGGAGSGDGGDAAESATASPGTGTGAAAGASPTSTGNSGPAATGILPGKNDAAPRAVGVAVFGSAMAVLGAVLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GN53</accession>
    <name>A0AAJ0GN53_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_262033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718817.1">
        <property type="nucleotide sequence ID" value="XM_062863349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GN53"/>
    <dbReference type="GeneID" id="87882178"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3303037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="126" mass="14552" checksum="1D023DDCB7AF0D26" modified="2024-07-24" version="1">MGMNLFDRIQAKIELFRLEQRYTRRRHRRSTFVSNAIYVDGEYIYQSPNTTGSSTSTSKSASTQYTTTPVHSVEEPTSKQQKKLNRWSSMPGFGSSAKPEVMGGLPSVREHEDRRKRVSFHDERGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GNS2</accession>
    <name>A0AAJ0GNS2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Leucine-rich repeat-containing protein 40</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_539371</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718940.1">
        <property type="nucleotide sequence ID" value="XM_062869726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GNS2"/>
    <dbReference type="GeneID" id="87888555"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF27">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="58"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="828"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="58"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="108"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="219"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="249"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="294"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="315"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="365"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="829"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="842"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="852"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="871"/>
            <end position="882"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3303160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1140" mass="121858" checksum="135613B1F5929063" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GNT1</accession>
    <name>A0AAJ0GNT1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="9">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0T15DRAFT_486805</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="9"/>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719134.1">
        <property type="nucleotide sequence ID" value="XM_062866386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GNT1"/>
    <dbReference type="GeneID" id="87885215"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17932">
        <property type="entry name" value="DEXQc_UvrD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.486.10">
        <property type="entry name" value="PCRA, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070:SF2">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE SRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 11 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="13">
        <location>
            <begin position="12"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="14">
        <location>
            <begin position="291"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="682"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="761"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="830"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="691"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="893"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="33"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3303354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="944" mass="104583" checksum="EBF48F766CFD7A6B" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GP36</accession>
    <name>A0AAJ0GP36_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytoplasmic tRNA 2-thiolation protein 1</fullName>
            <ecNumber evidence="6">2.7.7.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Cytoplasmic tRNA adenylyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">NCS6</name>
        <name evidence="6" type="synonym">CTU1</name>
        <name evidence="10" type="ORF">B0T15DRAFT_269654</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="6"/>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GP36"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002144">
        <property type="term" value="C:cytosolic tRNA wobble base thiouridylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="CTU1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03053">
        <property type="entry name" value="CTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056369">
        <property type="entry name" value="CTU1-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032442">
        <property type="entry name" value="CTU1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000541">
        <property type="entry name" value="Ncs6/Tuc1/Ctu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035107">
        <property type="entry name" value="tRNA_thiolation_TtcA_Ctu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020554">
        <property type="entry name" value="UPF0021_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11807">
        <property type="entry name" value="ATPASES OF THE PP SUPERFAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11807:SF12">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16503">
        <property type="entry name" value="zn-ribbon_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004976">
        <property type="entry name" value="ATPase_YdaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01263">
        <property type="entry name" value="UPF0021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 6" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal" evidence="8">
        <location>
            <begin position="53"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Cytoplasmic tRNA 2-thiolation protein 1 C-terminal" evidence="9">
        <location>
            <begin position="370"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="57"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR004976-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3303285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="402" mass="44118" checksum="1D6C11024AB3DF92" modified="2024-07-24" version="1">MAPALCANCMTERAVIKRPKNHAKLCKACFITVFEDEVHHTITSSQLFYPGEKVAIGASGGKDSTVLASVLKTLNERHGYGLELVLLSIDEGIKGYRDDSLETVKRNAVQYDMPLKVVGYDELYGWTMDQVVETIGKKGNCTYCGVFRRQALDRGAKMLGIKHVVTGHNADDVAETVLMNLLRGDLARLSRSTSIVTGDSRSEVKRSKPLKYSYEKEIVLYAHHKKLDYFSTECIYSPEAFRGSARGLIKQLERVRPTAILDIVRSGEDMARLVPGESSSSCACRGQNTGAFASAEDDIGGCGSQNGRTAGNEMAVMDKQLRDNEAHEGLETDVAKTMAESKQRGHGQQVKLGLRSENGAPHGVTRQILGNCKRCGYMSSQEICQACMLLEGLNKNRAKIQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GP67</accession>
    <name>A0AAJ0GP67_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Nicotinamide-nucleotide adenylyltransferase</fullName>
            <ecNumber evidence="17">2.7.7.1</ecNumber>
            <ecNumber evidence="17">2.7.7.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">B0T15DRAFT_496105</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD(+), NADH, NaAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+). Protects against axonal degeneration following injury. May be involved in the maintenance of axonal integrity. Also functions as a stress-response chaperone protein that prevents toxic aggregation of proteins; this function may be independent of its NAD(+) synthesis activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 17">
            <text>beta-nicotinamide D-ribonucleotide + ATP + H(+) = diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21360"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="EC" id="2.7.7.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 17">
            <text>nicotinate beta-D-ribonucleotide + ATP + H(+) = deamido-NAD(+) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22860"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="EC" id="2.7.7.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">Belongs to the eukaryotic NMN adenylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.1" evidence="17"/>
    <dbReference type="EC" id="2.7.7.18" evidence="17"/>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719344.1">
        <property type="nucleotide sequence ID" value="XM_062867159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GP67"/>
    <dbReference type="GeneID" id="87885988"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004515">
        <property type="term" value="F:nicotinate-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09286">
        <property type="entry name" value="NMNAT_Eukarya"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000221">
        <property type="entry name" value="Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051182">
        <property type="entry name" value="Euk_NMN_adenylyltrnsfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005248">
        <property type="entry name" value="NadD/NMNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045094">
        <property type="entry name" value="NMNAT_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00482">
        <property type="entry name" value="nicotinate (nicotinamide) nucleotide adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12039">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12039:SF0">
        <property type="entry name" value="NICOTINAMIDE-NUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12 17" id="KW-0520">NAD</keyword>
    <keyword evidence="10 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 17" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7 17" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="19">
        <location>
            <begin position="51"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="267"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="267"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="286"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00093425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAK3303564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="295" mass="32682" checksum="F348DDBBF42B311E" modified="2024-07-24" version="1">MTSGSIDSGTQTPSAHIEQSPLDGAQTPYTFPTHKLKRRQTQPGKTPLVLVACGSFSPITYLHLRMFEMASDFVRFNTDFEVCAGYLSPVSDAYKKVGLAPGHHRVNMCSRAVEHSPWLMVDPYETVNCDENGQPQYVPTAKVLRHFDHEINTVLGGIEGTDGQMRKARIALLAGADLVMSMGEPGLWAPKDLDTILGQYGAFIIERSGTDIDEALASLRQYEHNIWVISQVIQNDISSTKVRLFLKKDLSVRYLIPDPVYIEEHGLFQEPKPNKSRDNTPDVTAGPSNQKPAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GPK9</accession>
    <name>A0AAJ0GPK9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histidine phosphatase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_540565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719335.1">
        <property type="nucleotide sequence ID" value="XM_062869795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GPK9"/>
    <dbReference type="GeneID" id="87888624"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF54">
        <property type="entry name" value="PHOSPHATASE SPAC5H10.03-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3303555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="254" mass="28424" checksum="5113A29DEF8F675C" modified="2024-07-24" version="1">MPTYVHLVRHAQGFHNLCAANHSLPDPDLTPLGKEQCAALQKTFPFQDQITHLVASPLRRTIYTCLLSFEPAVKAGKRVIALPEVQEVSPLPCDTGSSAETLAGEFAEKVDLGLVKDGWNDKAGASPFAPAMDRLEARARKARVWLRELGRQFEREQPGVDAHIIVVTHGGFLHFLTQDWDGMNPAAGTGWANTEWRTYEFVDEKGEDADASLRETKVSWRRRRGSAQPLTETEQMELRVATKSRMEEEWGGQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GPV5</accession>
    <name>A0AAJ0GPV5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_421166</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719485.1">
        <property type="nucleotide sequence ID" value="XM_062865553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GPV5"/>
    <dbReference type="GeneID" id="87884382"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015606">
        <property type="term" value="F:spermidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000297">
        <property type="term" value="F:spermine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140115">
        <property type="term" value="P:export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF38">
        <property type="entry name" value="POLYAMINE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="451"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="44"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3303705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="504" mass="54592" checksum="303721517289B2EE" modified="2024-07-24" version="1">MAMPTMTTAQQEPQASNTGDEIDWRGPDDPDCPYNWPMRKRIYMTSIPALLCVNVSFASSVYTSGASDIERTFGVTRTEALLGLSLFLWALGLGAIIAAPVSEYYGRRIVYLTTVPVFGLFILGSGLAQNFATLIVCRTLAGFFGSAVVSVGGGTNADLWPPKLAGFVYPFYFVSPFLGPAFGPVIGGYLVEAKGFRWLEWVILFMLAFVYLYSLPQSETYKKTILQKRTRSEKRSNAPPATKKFALPSGALIQRIVLKPFKMLFVESIVLFMTIYMAFNFAVFYSFFAAFPYIFGGGGGKYNFSSGQQGLTFISIALGCVIGFVAVVYIDRRTYPALEAKYGVGAVPPEYRLYGAMVGCALNPASLFWFGWSANAGAFWPSPVVAAVPFAVGNIMVYSSGALYIMNSYGSLHGASALSANSLLRYAGGGAFPLFTVQMFSSLGIGWASSLLGFVSVALVPVPFVLYKYGDRIRTNSQYITVKEPVLANHNSSGETTSGEETGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQW0</accession>
    <name>A0AAJ0GQW0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ribonuclease III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_512570</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720196.1">
        <property type="nucleotide sequence ID" value="XM_062867995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQW0"/>
    <dbReference type="GeneID" id="87886824"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207:SF0">
        <property type="entry name" value="RIBONUCLEASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207">
        <property type="entry name" value="RIBONUCLEASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNase III" evidence="8">
        <location>
            <begin position="69"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="7">
        <location>
            <begin position="224"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3304416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="330" mass="36143" checksum="CAAE14242AD96D96" modified="2024-07-24" version="1">MPKRAHGESDTATEAGAVQPALKRPKPDETSDTSSTAPPIPLHTAFFKWTSSSVSQTYPPLPQVLDPALETAALTHSGMRKSLADLSYERLEWIGDVYLELIASELIYATFGTLEPGKCSHYREMLVRNSTLGQFSVHYGLDKRANFPAEFGLGGRPKGTTASQKQRTKALGDIFEAYVGALVRSDPEHGIRRATEWLKALWGPVLERHIRDEESGAHVISDVNPKTQLERLIGVPGVKIEYRDLPSNGKRDKDTKQQLFSVGCFLHGWGETGLQLGYGSALGKKEAGQNAALKAMENKKLIKKFAEKKKAFQDARAAQASTEGGEGKQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GRB1</accession>
    <name>A0AAJ0GRB1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_251269</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720489.1">
        <property type="nucleotide sequence ID" value="XM_062863184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GRB1"/>
    <dbReference type="GeneID" id="87882013"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000018">
        <property type="entry name" value="Heme/steroid binding domain protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF76">
        <property type="entry name" value="CALCUTTA CUP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="4">
        <location>
            <begin position="110"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="246"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3304709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="272" mass="31017" checksum="CE68C75B401E852D" modified="2024-07-24" version="1">MADSDTSARRRKLDPDAVKAKLEEIDRDVETEKAHKNPRKRTVQDRLDDDNAYTSLYLDIFRVLTFLFLASCGLSYLISGGETLFWGMSNPPKYLQADWWKKQFRGPIYLTPAELAAYDGTDPTKPIYLAINWTIYDVSANRRTYGPGGSYHYFAGCDAARAYVTGCFAEDRTPDMRGVEEMFLPLDDPAVDRHWSGAELAQLRAKERAEAEKKVHEGLAHWVDFFRNNPKYDFVGYVKKPEGWPGTEPRRPLCEAAAKGRKRRVVPGQEGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GRS5</accession>
    <name>A0AAJ0GRS5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycosyltransferase family 15 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_537329</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720475.1">
        <property type="nucleotide sequence ID" value="XM_062869606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GRS5"/>
    <dbReference type="GeneID" id="87888435"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF2">
        <property type="entry name" value="MANNOSYLTRANSFERASE KTR5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018153">
        <property type="entry name" value="Glyco_trans_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR018153-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3304695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="449" mass="51636" checksum="7E7056C1763E5BDA" modified="2024-07-24" version="1">MKLLHALAVAFVRRVRRPVRRVSILLKGAAVVFLLCIIEAFLHRYLHSIPRPPQDLDGPFARQCQDPRIAAAQPREKAAFVMLARNSEIDEARQTIQNIEAQFNQWFHYPVVFLNNEEWDPEFVRDLNASVSGKAIFDVIPKEDWSYPSWVDPAKARQSMAQQDKSGVWNGGKESYHHMCRFYSGTFYTQPALAPFKWYWRLEPGVRYTCAITYDPFVEMARHGKSYGFTIALWEEPNTCPSLFRAVDDFRTQHGLPSSPTWNAMLDTASWSQQAWPVRKLLGLLGRAHHARSGDRWNLCHYWSNFEIADLDFFRGKAYQSLFGHLDRQGGFYHERWGDAPVHSLAVHLLLPPGKLHHFSDFGYHHEPFFQCPGNAPGGQLPGNEALGNGEWSAESEGAVGCRCRCPDQRRRNNRGICLDTMQAPAAFHRTGWWEKYRGRYPYTINIPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GSL6</accession>
    <name>A0AAJ0GSL6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sedlin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_555436</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721119.1">
        <property type="nucleotide sequence ID" value="XM_062870392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GSL6"/>
    <dbReference type="GeneID" id="87889221"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006722">
        <property type="entry name" value="Sedlin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12403">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04628">
        <property type="entry name" value="Sedlin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3305339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="195" mass="21276" checksum="A2B0E65A2147D101" modified="2024-07-24" version="1">MATTIPSIACLGVIGRNNNPLHTSIFPSYDPSTNSYHPVRTPLQFSLILSSTLDVFELRSRQNQAAGVGLTGDFGLLHAVDDRLAAYGFETNTGIRFVVIVDMRGRRIDSAVAAGLADGRDKRIAGAAAGLREGEMRPVFKAMQAAYIRLTQNPFYDPDEHSSPLGHGGKKIMSKKFAEEMRRIGENWTPGITNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GSR0</accession>
    <name>A0AAJ0GSR0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_493589</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721201.1">
        <property type="nucleotide sequence ID" value="XM_062866956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GSR0"/>
    <dbReference type="GeneID" id="87885785"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF161">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="33"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="284"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="332"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3305421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="377" mass="41604" checksum="0F63653913DDCB1A" modified="2024-07-24" version="1">MFDYVEFPVLPVVRTHLIINSVLAGLTVLVVALRLVARFMSGAGLWWDDYLILFALPQGLGMLIIQGLWSPMGIGFPVTETMPNLFTILKFLVAYELIYSTAISTIKFSVLVFYLRVFVNDRMRLYTKLALGFVGTWSVGNLLQVFLICRPFRRTYDPTVDGTCGNQIASFIAIGAFNIISDVMILTLPLPTVWSLKMATPAKLGLTGVFLIGLLVSVIAIIRIVTLTQLDLTNLTGTMVWADFWSATEPNLGILCVSLPMLGTLWSRCVASTRRGASKLGYHSSENGTHGSAFSKLRNPSNVDTQIPLEGIYAANQEVHYQSAVAAATTPELDRGHTHGDRDRDSGSEVALTDQEQHYKQDANGIRVQTKWTISHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GSR4</accession>
    <name>A0AAJ0GSR4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_196512</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721194.1">
        <property type="nucleotide sequence ID" value="XM_062862515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GSR4"/>
    <dbReference type="GeneID" id="87881344"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3305414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="114" mass="12295" checksum="42581E92A3F5EC0E" modified="2024-07-24" version="1">MAVVETGADWEPNLTLLQTPAATLVKLGEIVRNATLALPHEGAVPDLIDMDAQGHTSSCGSCTIFWTTLRLQQRTWAKSTYPPCAVCQTWPLLDITACIISVQPRPTSIGYGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GT51</accession>
    <name>A0AAJ0GT51_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_533034</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721448.1">
        <property type="nucleotide sequence ID" value="XM_062869339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GT51"/>
    <dbReference type="GeneID" id="87888168"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="7">
        <location>
            <begin position="37"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3305668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="334" mass="36763" checksum="DFBF2BB7EE015BF7" modified="2024-07-24" version="1">MFVGKLLPIRQARHNTSRMANTGLVLVAPGTDPKVDIVFVHGLRADMEKTWTRDTVLWPAQLLPKEFPEARIFLFGYDSTIFNLQPGKLAKTEVRSNADDLCSKLAAERSKEPEAGNRPIVIVAHSLGGLVAAQLFNNGEQSSEDTNARAIVKNIRGLIFLGTPFRGSVPAGPAEYARRILKLLGVETQEHTLKLLGVNSEMINELARTFSNLLNKRRMSKNAEDRISASFFYETLTTRVTGTLKYIQVVENDSAQLPGCGDAIPIRADHHDICKFTSEKDEGYGLIVAEIRKSLAPPDLDDEGAGGRGTWVYNYGKAVNVGKIQIDSQTNTIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GTZ2</accession>
    <name>A0AAJ0GTZ2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LEA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_216915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3306042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721822.1">
        <property type="nucleotide sequence ID" value="XM_062862749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GTZ2"/>
    <dbReference type="GeneID" id="87881578"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3306042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="16108" checksum="0EAA75BBE62F85FC" modified="2024-07-24" version="1">MSALTSRSGALARRLATTTTTASRTSTISRAAFTTTAPQHKSPVDSAKETLKQVDRKVSDKLVDGINIGSAVANKIKEAAQEVKTGKVTGKAEELRGEVKGKASEVAGEAKGKASEMAGEAKGVKDEMAGKAKGMKEEVKGQAKEAMGEAKQKMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GU63</accession>
    <name>A0AAJ0GU63_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Peptidase S8/S53 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0T15DRAFT_534750</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="8">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3306236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722016.1">
        <property type="nucleotide sequence ID" value="XM_062869457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GU63"/>
    <dbReference type="GeneID" id="87888286"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF19">
        <property type="entry name" value="SERINE PROTEASE AORO, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 8" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042608824" evidence="10">
        <location>
            <begin position="24"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53" evidence="11">
        <location>
            <begin position="265"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="212"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="346"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="640"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="681"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="682"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="700"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="702"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3306236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="723" mass="78800" checksum="E242AF9FF10A486A" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GU82</accession>
    <name>A0AAJ0GU82_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_551910</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722046.1">
        <property type="nucleotide sequence ID" value="XM_062870279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GU82"/>
    <dbReference type="GeneID" id="87889108"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043792655" evidence="6">
        <location>
            <begin position="25"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3306266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="503" mass="56225" checksum="AED5BE9A6FDE99D6" modified="2024-07-24" version="1">MVISYRDLFLLGLSVLVANGATTAREPEWEQHHTRICENTPGVKAYSGYVNLPGSTTEGRLYDIHIFFWFFEARKDPYKNGPCLVTHDSKNTVWNPWSLINGTIDETLLPYEVTPLPLSSPDPLSTANTTAIAALAYKPRDNKFSIWTESYGGYYGPAFADFFTVQTQKIADSRITSGAVPLQVDTMGIINGCVDIFTQMPSYPRMVYNNTYGVRVTNETEYDTAPAMFPACRESVESCRAHAAERDPTGLGNVEEVNKACNEAYLLCFATMWGGVQDRGRDIFDITATYPSAFPPKYAGGYLNSREAQQEVKVGLVYRDRDCQCNWYGGEQVSLAIQSKTRQGFHAAGYADIQTNKTYTGGLVRQYGNLSFSRVFGAGHESKFSTAPPYRMQLFWLILCLAPWYQPETAYQIFRRVMFNKDVATGGISTAKCRGKVYSTTGPGDVSGILNELPSHPEPECYLWDIFQTCTPLQTEMLRNGTAVLKDFIMIGYTLPNGAVHYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GUA4</accession>
    <name>A0AAJ0GUA4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_394498</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722043.1">
        <property type="nucleotide sequence ID" value="XM_062864729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GUA4"/>
    <dbReference type="GeneID" id="87883558"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22584">
        <property type="entry name" value="Rcat_RBR_unk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="3"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3306263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="293" mass="33306" checksum="F6E87EF35AF0283E" modified="2024-07-24" version="1" fragment="single">PMRTAQCTACTEWCSPDDLAIASCGHEYCRDCLRALFRASLADETLFPPKCCKQLFDLESCHALLTSDLVTQYGEKEVEFRTPAVQRTYCHACSAFVPRQRVEADVAYCGRPGCHAQTCTFCKAASHEGSHCPQDPARQELERLAAAEGWQHCYGCNRIVELDTGCYHITCRCGADFCYLCGEAWIECTCPQRDEARLFRRAEANVDRNVGAAPMGHREWAAALVEWQRLGLARLWGNHECDHTAWIRRWGAHTGMTSCWRGILRRRDWTQDYSTILHYYRVMRGIGCVGFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GUS4</accession>
    <name>A0AAJ0GUS4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_369882</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722298.1">
        <property type="nucleotide sequence ID" value="XM_062864192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GUS4"/>
    <dbReference type="GeneID" id="87883021"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051196">
        <property type="entry name" value="RSAD2/Viperin_antiviral"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038283">
        <property type="entry name" value="viperin_w_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21339">
        <property type="entry name" value="RADICAL S-ADENOSYL METHIONINE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21339:SF0">
        <property type="entry name" value="S-ADENOSYLMETHIONINE-DEPENDENT NUCLEOTIDE DEHYDRATASE RSAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01088">
        <property type="entry name" value="antiviral_proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01067">
        <property type="entry name" value="SPASM/twitch_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00318">
        <property type="entry name" value="Viperin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="9">
        <location>
            <begin position="1"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3306518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="295" mass="33390" checksum="B4DAC8E412EEE84E" modified="2024-07-24" version="1" fragment="single">KIPVSVNYHFTRRCNKTCGFCFHTATTSHIEDLPRQKAALRLLAQAGMRKINFAGGEPFLYAKPLGAMIDFCKRELRLESVSVVTNGSLVREAFLRQHAGQLDILAVSCDSFNEQTNIAIGRGSGDQVRKLYQIAEWCRRYGVMFKLNTVVNKLNVAEDMNAHIAALKPFRWKCFQVLIVQGENDSEATLRNGHKFTISDDEFDEFCERHKGQACLVPEPNRLMARSYLILDEYLRFLDRTGKQPSRPILEVGVQRALESVYWDEDAFVERGGLYEWSRQEGAGGGGCAEGKELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GVE9</accession>
    <name>A0AAJ0GVE9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Probable electron transfer flavoprotein subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_413531</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </cofactor>
        <text evidence="7">Binds 1 AMP per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="7">Binds 1 FAD per dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ETF beta-subunit/FixA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722663.1">
        <property type="nucleotide sequence ID" value="XM_062865426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GVE9"/>
    <dbReference type="GeneID" id="87884255"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01714">
        <property type="entry name" value="ETF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000011">
        <property type="entry name" value="Electron transfer flavoprotein subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000049">
        <property type="entry name" value="ET-Flavoprotein_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033948">
        <property type="entry name" value="ETF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN BETA-SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294:SF8">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000090">
        <property type="entry name" value="Beta-ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01065">
        <property type="entry name" value="ETF_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Electron transfer flavoprotein alpha/beta-subunit N-terminal" evidence="8">
        <location>
            <begin position="26"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00070315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3306883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="258" mass="27789" checksum="7D72CB97AF186631" modified="2024-07-24" version="1">MSALRILVPVKRVIDYAVKPRVNKAQTGVETAGVKHSMNPFDELSVEESVRIREKNRAPGGVEDICVLSAGPPKAQDILRTAMAMGADRAIHVEVKEGEDLEPLAVAKLLKAAAEQQKSNLVILGKQSIDDDANQTGQMLAGLLGWPQATQASQVEFGEGDTVSVTREVDGGVETVRAKLPMVITTDLRLNEPRYASLPNIMKAKKKPLEKKTLADFGISAEKRLKVLKVTEPPARQGGGKVEDVDGLISKLKELGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GVI5</accession>
    <name>A0AAJ0GVI5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sac2 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_147815</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS52 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722410.1">
        <property type="nucleotide sequence ID" value="XM_062861954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GVI5"/>
    <dbReference type="GeneID" id="87880783"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007258">
        <property type="entry name" value="Vps52"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048361">
        <property type="entry name" value="Vps52_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048319">
        <property type="entry name" value="Vps52_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14190">
        <property type="entry name" value="SUPPRESSOR OF ACTIN MUTATIONS 2/VACUOLAR PROTEIN SORTING 52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14190:SF7">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Vps52_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Vps52_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vps52 coiled-coil" evidence="7">
        <location>
            <begin position="161"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Vps52 C-terminal" evidence="8">
        <location>
            <begin position="343"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3306630.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="668" mass="73614" checksum="640F87F04AFFB097" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GVW9</accession>
    <name>A0AAJ0GVW9_9PEZI</name>
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        <recommendedName>
            <fullName evidence="4">Exocyst complex component SEC5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_528743</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
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        <text evidence="4">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the exocyst complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SEC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062869060.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87887889"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029175">
        <property type="entry name" value="EXOC2/Sec5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039481">
        <property type="entry name" value="EXOC2/Sec5_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13043:SF1">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13043">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT SEC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15469">
        <property type="entry name" value="Sec5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component EXOC2/Sec5 N-terminal" evidence="7">
        <location>
            <begin position="72"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="45"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1011"/>
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        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="398"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF15469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3306970.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GVY5</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">B0T15DRAFT_155596</name>
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        <name type="scientific">Chaetomium strumarium</name>
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            <taxon>Sordariomycetes</taxon>
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            <taxon>Chaetomiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722635.1">
        <property type="nucleotide sequence ID" value="XM_062862046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GVY5"/>
    <dbReference type="GeneID" id="87880875"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="546"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3306855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="560" mass="60919" checksum="8794D3B0F6C7AFA7" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GVY7</accession>
    <name>A0AAJ0GVY7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_164194</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722869.1">
        <property type="nucleotide sequence ID" value="XM_062862145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GVY7"/>
    <dbReference type="GeneID" id="87880974"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039146">
        <property type="entry name" value="GPANK1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20923">
        <property type="entry name" value="BAT4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20923:SF1">
        <property type="entry name" value="G PATCH DOMAIN AND ANKYRIN REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="133"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3307089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="233" mass="25731" checksum="765A4D137F45C4D0" modified="2024-07-24" version="1">MSLQKDKDIEDDDYDDIPLQHKRPFGAGLHRKPIAFVSASDGDGHLKSVDDAAVDKGKTDVADLYLSMVLPDDATRSKSAPPSSGSARDNERPESELCAVCRLPLGTDKETHEQSFAHQVCLPYSQPPSALDRSRKGLAYLSAYGWDPDARRGLGAEQQGIQYPIKPKVKDDNLGIGMEVPKGLPPPKKKEQLLDAKKVRKMALDEKKKAARIHQELFGDSKLEKYLGKRGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GW42</accession>
    <name>A0AAJ0GW42_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sensitive to high expression protein 9, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0T15DRAFT_529684</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Required for the maintenance of the structure of the mitochondrial inner membrane. Involved in mitochondrial morphology. Causes growth arrest when highly overexpressed.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion inner membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the SHE9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723017.1">
        <property type="nucleotide sequence ID" value="XM_062869122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GW42"/>
    <dbReference type="GeneID" id="87887951"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008839">
        <property type="entry name" value="MDM33_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31961">
        <property type="entry name" value="SENSITIVE TO HIGH EXPRESSION PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31961:SF3">
        <property type="entry name" value="SENSITIVE TO HIGH EXPRESSION PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05546">
        <property type="entry name" value="She9_MDM33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="465"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="58"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="199"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="351"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="94"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="123"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3307237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="494" mass="53775" checksum="ECBBBA8A2A1730E8" modified="2024-07-24" version="1">MSPNTALRLAVRPLRGVAVLDQLATAAASRHVSQFPPIMVCVRCSVAVGIRFAASRARHFSTAPPPPRRPPPPNPRDNGDKPEPETAGSKDAAPPTPASPPPAEQPTPPGPEPSPPPSPEPAASPESASPEPSQSDKQPAPPPSPENNEPLPSDRSLPSFSETHRHPLSARFSTFMDNLQSRALTATQKINDLTGYSAIEAIKAQNSQLEREHAAAQARLRAARHNYKSLTSHRASTQREVTTLLARKDTWNPADLERFTTLYRSDHELEAQVAAAAAELTEAETEESRLSGELNAGILKRYHEEQIWSDRIRRQSTWGTWGLMGVNVVLFLVLQFVAEPWRRKRLMRGIAEREEGVFEEVKRELEEVKAAVAAAALRERQAAAAAAAAQAEELTPAVVVEGEDGVGLVDPSPATTPVGLEEEDARPRKPWKEFMLDYWEDPELLKADVLDLTSERRINLRMRDVSLIALQGAVAGATVAAALALVLLRSSSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GWD0</accession>
    <name>A0AAJ0GWD0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RTA1 like protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_172234</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723069.1">
        <property type="nucleotide sequence ID" value="XM_062862208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GWD0"/>
    <dbReference type="GeneID" id="87881037"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF8">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14140)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="311"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="317"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3307289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="365" mass="39892" checksum="69FA708791BA9B15" modified="2024-07-24" version="1">MDKFDPSMIPPGMDQQDIDNLIANYYYSCKEVTAYCPVEATTLGYYPNRGINIFFAIGFALAMIVTLVLGVWKKTWSYMAFIAAGCALEFAGYAARIPLTDNPWNKNAFETQIVAIILAPTLICISIYLTLKHVCLSLNPALSRVRPHLYPFIFVPLDVSCLCVQAIGGSLAASGAKVNLDMVNHGNRCIIAGIVLQVVVLLFFGTSAGDYFLRVKKWIKSDGADPEAVALWHDKRFRMFMYAVAGAYSGILIRCIYRIAEMAGGWGNPIMQDEPSFIVLEGFMVLIPCLLLAFFSPGILFPQMAARMSGPGRIGPGHKDGNKSNPEKQSQPEGHEGRQHVASGDESPPSEIHAKETPTSASPAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GWP6</accession>
    <name>A0AAJ0GWP6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_501904</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723170.1">
        <property type="nucleotide sequence ID" value="XM_062867408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GWP6"/>
    <dbReference type="GeneID" id="87886237"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF155">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="107"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="355"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="433"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3307390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="456" mass="49410" checksum="BAD62C6FC1CE005D" modified="2024-07-24" version="1">MAVVRSCLKDTNYPMANRGPPPAFPDLQIDAVDDDADSAREVSTCVPSLLNGLDAAITPLLSTTPIRITSMALWQEEDYGVLADRACWAMFAVTVVVVALRVFCRAYYGRARGGGLGRDDYITLGCLAVFLATCILITIGSSYGLGKHFKDVPPEHIIMALKYNVIISAVLIWTFSLPKFAVVSTLQRILEPGIKTTVAFWALALSSQACILATSVWWFKQCDPVEHGWDRSVPGSCASVDILANLGYFTSAYSAFLDLFFAVYPIPFIMRLNMPLKTRITVATLLGLSSLACVVSIYKLAIFGQVFQILAVDPTYPVPYLDILGVAEGCILMVCASLPTLGPLYRAARGRLTDGSQVTSQRTGTGQFGNSQGLSHGGSRNWDNVRGHKLDSDVEASSLNLRPSFDAIPLVSTAKTHGVADPESMGIHKTMEVSVSSETLKEDSRGRRSRSSVYVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GX26</accession>
    <name>A0AAJ0GX26_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GMC oxidoreductase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_530840</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723459.1">
        <property type="nucleotide sequence ID" value="XM_062869196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GX26"/>
    <dbReference type="GeneID" id="87888025"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF115">
        <property type="entry name" value="DEHYDROGENASE XPTC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042511512" evidence="3">
        <location>
            <begin position="19"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="4">
        <location>
            <begin position="305"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="124"/>
            <end position="127"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3307679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="629" mass="68477" checksum="A7CF077BF5DE64EF" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GX35</accession>
    <name>A0AAJ0GX35_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_530980</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723499.1">
        <property type="nucleotide sequence ID" value="XM_062869208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GX35"/>
    <dbReference type="GeneID" id="87888037"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47840:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47840">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="13"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3307719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="704" mass="77049" checksum="902FA9CFF82F28F6" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GX82</accession>
    <name>A0AAJ0GX82_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_549733</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3307843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723623.1">
        <property type="nucleotide sequence ID" value="XM_062870229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GX82"/>
    <dbReference type="GeneID" id="87889058"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3307843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="324" mass="33832" checksum="F4A143F0268AAE26" modified="2024-07-24" version="1">MDGSDGELGEDHYPWSALAASRGVSTPSPKQHQGPFPTSPSSLTVDGSPKGSESDGETESYGAQFLDGHPGSARDSTFPGADSTVPRHFSRPPPPPPLTPPTLSAGAFPFEDRRPGYATSVPPALDMSFIHQPNPDYGASATSTDALSSSAQTALPRRRSYTRSIPIGIPTASTPASSSITETDTSTASGRSTLHNSFAPSSHPQASFFLPPPPPGHYDNVPPSAPPEYEFVGGPGGPGVEIDVQGEIISVVDDAGHGWTRHTRVYGGGVCLACLAAAERHGPGQGGFYGDKVPLEDRRDIHMHRCEFAVRENGGELGDRAKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GXF1</accession>
    <name>A0AAJ0GXF1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">thioredoxin-dependent peroxiredoxin</fullName>
            <ecNumber evidence="3">1.11.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Nuclear thiol peroxidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Thioredoxin peroxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0T15DRAFT_410067</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the peroxiredoxin family. BCP/PrxQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="3"/>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3307914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723694.1">
        <property type="nucleotide sequence ID" value="XM_062865367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GXF1"/>
    <dbReference type="GeneID" id="87884196"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03017">
        <property type="entry name" value="PRX_BCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000157">
        <property type="entry name" value="DOT5p Nuclear thiol peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050924">
        <property type="entry name" value="Peroxiredoxin_BCP/PrxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42801:SF23">
        <property type="entry name" value="PEROXIREDOXIN DOT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42801">
        <property type="entry name" value="THIOREDOXIN-DEPENDENT PEROXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0477">Merozoite</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="15">
        <location>
            <begin position="10"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00077538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3307914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="206" mass="21150" checksum="31634E7824BB3AB6" modified="2024-07-24" version="1" fragment="single">MPMELRKRKAPAAPPAPTAKKPSKAAKIASETKEKVKEKAAEAVGSANGSTSKPTVGDIITLDGFGGEIETNDGTKTTLKALVDESKAGVVLFTYPKASTPGCKSQACLFRDAYTALTGASGLAIYGLSTDSPKANTTFKDKQKLPYPLLCDPQASLIGAVGLKKAPKGTTRGVFVVDKAGKVLAAQAGTPEGTVNVVKGIVESLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GXN1</accession>
    <name>A0AAJ0GXN1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein L5 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_490666</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723841.1">
        <property type="nucleotide sequence ID" value="XM_062866700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GXN1"/>
    <dbReference type="GeneID" id="87885529"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_uL5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_uL5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_uL5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_uL5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="RL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL5 N-terminal" evidence="4">
        <location>
            <begin position="189"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL5 C-terminal" evidence="5">
        <location>
            <begin position="247"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3308061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="351" mass="39190" checksum="DE726F818BB390AD" modified="2024-07-24" version="1">MASLRGLSRPARSLPLSQLSRQTFTAGSIRCASSQAAEAAAPVLNELEQSTLMAPQLSPEEKKEFRPWKRGADRKFQLPGGRYQFHPPKYQRGPLHPIQSPPSSDPVARDFVPGPFNLPRLKQTYHSTIAPDLMTLTYMHVPPGTPPKPAPERLRAWDGSSPYHKNRPLRGPMGNSALPLMERHINFRNIPEIKEVTLASYVPDAIKDPDHLLVARSVLLALTGTTPEITHTKSNVVQWGIKAGEKAGVKTTIYGNAAYEFLDRCVHMVFPRIKDWRGIRATTGDDSGNLSWGFTPEEIKLFPEVEVNYWLYPAKMVPGCRVYVKTSATSDRQARLLLQAFGVPFYGTVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GXW5</accession>
    <name>A0AAJ0GXW5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">rRNA biogenesis protein RRP36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0T15DRAFT_500051</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Associates with 90S and pre-40S pre-ribosomal particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
            <location evidence="1 10">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the RRP36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723976.1">
        <property type="nucleotide sequence ID" value="XM_062867359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GXW5"/>
    <dbReference type="GeneID" id="87886188"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009292">
        <property type="entry name" value="RRP36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21738">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 36 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21738:SF0">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 36 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06102">
        <property type="entry name" value="RRP36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 10" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 10" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="229"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="79"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="136"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3308196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="343" mass="38937" checksum="760611ABF7DCC191" modified="2024-07-24" version="1">MSSTKRKMPPASLLQRRVRPRYEPEPESDIEDDVSEAPSEEGVGSLGSDEEDEDLSEDESRNSGDEGRSDEASESGSGSDEDEDEDEDEETPQVDASQLSFGALAKAQSALGSSSRRRRADAANEKEGDGSMQPTRGDRGAKKKKPEKEKRPSKHAPAVASSKYPVSRKRDFLTVTAVELKKPQPRDPRFMPLGPGATTSSSTSTSHKIDEIKARKAYAFLDEYRESEMRQLREAIKKTKNAAQREELQKALMSMESRKKAQERKDKERAIIEEHRRKEKELVKQGKKPFYLKRSEQKKRLLVDQFQHMKKKQVDKVIERRRKKIAGKEKKLLPLARRGAEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GY30</accession>
    <name>A0AAJ0GY30_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_104508</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724067.1">
        <property type="nucleotide sequence ID" value="XM_062861407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GY30"/>
    <dbReference type="GeneID" id="87880236"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF50">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <end position="433"/>
        </location>
    </feature>
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        </location>
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        </location>
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        </location>
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    </evidence>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0016787">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="4">Secreted protein</fullName>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
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                <person name="Riley R."/>
                <person name="LaButti K."/>
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                <person name="Chen C."/>
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                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
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                <person name="Lalanne C."/>
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                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062868775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GYJ2"/>
    <dbReference type="GeneID" id="87887604"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="chain" id="PRO_5042555292" description="Secreted protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3308489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="82" mass="8999" checksum="145E20B0757B0A42" modified="2024-07-24" version="1">MQSCVMHLIFLHTALSAWKALSLTTRRRIDGVADSQCRASGIVLSPFRASRKPASWRSLRMLDASSVVPSAELMRAESAVDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ0GYN1_9PEZI</name>
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        <recommendedName>
            <fullName evidence="4">Spo12-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_491161</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724368.1">
        <property type="nucleotide sequence ID" value="XM_062866752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GYN1"/>
    <dbReference type="GeneID" id="87885581"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007727">
        <property type="entry name" value="Spo12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05032">
        <property type="entry name" value="Spo12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3308588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="120" mass="12723" checksum="D242BA37913C5DB9" modified="2024-07-24" version="1">MSSNVLAARDVNTSLPAQNQAGAQTGGAVKPDVMSMEYHRQVFQSKMEQGENKTYISPSDNIMSPCTAKLSAFRNKQVGKSVKGKSLFAQASAKKLEAGGSPKGDALFGNKPENNPFGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GZC1</accession>
    <name>A0AAJ0GZC1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Tryptophan synthase beta subunit-like PLP-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_525761</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-aminocyclopropane-1-carboxylate + H2O = 2-oxobutanoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16933"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58360"/>
            <dbReference type="EC" id="3.5.99.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ACC deaminase/D-cysteine desulfhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724731.1">
        <property type="nucleotide sequence ID" value="XM_062868867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GZC1"/>
    <dbReference type="GeneID" id="87887696"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008660">
        <property type="term" value="F:1-aminocyclopropane-1-carboxylate deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019148">
        <property type="term" value="F:D-cysteine desulfhydrase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009310">
        <property type="term" value="P:amine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06449">
        <property type="entry name" value="ACCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027278">
        <property type="entry name" value="ACCD_DCysDesulf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005965">
        <property type="entry name" value="ACP_carboxylate_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01274">
        <property type="entry name" value="ACC_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43780">
        <property type="entry name" value="1-AMINOCYCLOPROPANE-1-CARBOXYLATE DEAMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43780:SF2">
        <property type="entry name" value="1-AMINOCYCLOPROPANE-1-CARBOXYLATE DEAMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006278">
        <property type="entry name" value="ACCD_DCysDesulf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="8">
        <location>
            <begin position="20"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006278-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR006278-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3308951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="348" mass="37470" checksum="4D71BD6FF2C9FDC9" modified="2024-07-24" version="1">MSAVQLPEPFAGIPREVLTFGPSPIQHLPRISQALGGQVNVYAKREDCNSGLAYGGNKTRKLEYLVAEALAQGCDTLVSIGGVQSNHTRQVAAAAAKLGLGVALVQEHWVDWHDPGYERVGNIQLSRLMGADVRLDPSAFGIEHKQTLARLRDELAARGKKPYYIPAGASDHPLGGLGFARWALEVEQQERELGVFFDTVVVCAVTGSTMAGMVAGFKLAQKKLGSRKRRVVGIDASAKVKQTFEQVLRIAKMTAAKIGLDEGDITEADIILDDRYHAGTYGIPDEQTIEAIKFGARTEAFITDPVYEGKSLAGMIDMIRKGEIPAGSNVLYAHLGGQLALNAYSALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GZJ9</accession>
    <name>A0AAJ0GZJ9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_127868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3309053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724833.1">
        <property type="nucleotide sequence ID" value="XM_062861714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GZJ9"/>
    <dbReference type="GeneID" id="87880543"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="506"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="548"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="583"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3309053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="592" mass="65112" checksum="CF03A3729D00EF64" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H004</accession>
    <name>A0AAJ0H004_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="7">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_515161</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="7"/>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725078.1">
        <property type="nucleotide sequence ID" value="XM_062868166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H004"/>
    <dbReference type="GeneID" id="87886995"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08598">
        <property type="entry name" value="PI-PLC1c_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.190:FF:000039">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF169">
        <property type="entry name" value="PHOSPHOINOSITIDE PHOSPHOLIPASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PI-PLC Y-box" evidence="9">
        <location>
            <begin position="310"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="265"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="290"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3309298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="593" mass="65634" checksum="63E50962D09DE77F" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H047</accession>
    <name>A0AAJ0H047_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protection of telomeres protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_525790</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the telombin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724745.1">
        <property type="nucleotide sequence ID" value="XM_062868869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H047"/>
    <dbReference type="GeneID" id="87887698"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000783">
        <property type="term" value="C:nuclear telomere cap complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098505">
        <property type="term" value="F:G-rich strand telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010521">
        <property type="term" value="F:telomerase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032210">
        <property type="term" value="P:regulation of telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016233">
        <property type="term" value="P:telomere capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000303">
        <property type="entry name" value="Protection of telomeres protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028389">
        <property type="entry name" value="POT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032042">
        <property type="entry name" value="POT1PC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011564">
        <property type="entry name" value="Telomer_end-bd_POT1/Cdc13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14513">
        <property type="entry name" value="PROTECTION OF TELOMERES 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14513:SF0">
        <property type="entry name" value="PROTECTION OF TELOMERES PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02765">
        <property type="entry name" value="POT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16686">
        <property type="entry name" value="POT1PC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00976">
        <property type="entry name" value="Telo_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="Telomeric single stranded DNA binding POT1/Cdc13" evidence="10">
        <location>
            <begin position="27"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="366"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="505"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="607"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="413"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008442"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00015253"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="KAK3308965.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="690" mass="78144" checksum="41C86C9B2F5B880F" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ0H0J1_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">B0T15DRAFT_7550</name>
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    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_062871281.1"/>
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    <dbReference type="GeneID" id="87890110"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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    </feature>
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        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
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        <location>
            <begin position="22"/>
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        </location>
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        </location>
    </feature>
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        <location>
            <begin position="186"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3309596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H0V8</accession>
    <name>A0AAJ0H0V8_9PEZI</name>
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        <submittedName>
            <fullName evidence="7">Histone acetyltransferases subunit 3-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_516248</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NGG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725482.1">
        <property type="nucleotide sequence ID" value="XM_062868246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H0V8"/>
    <dbReference type="GeneID" id="87887075"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019340">
        <property type="entry name" value="Histone_AcTrfase_su3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13556:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13556">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10198">
        <property type="entry name" value="Ada3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="357"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="411"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="521"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="616"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="411"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="443"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="530"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="616"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="626"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3309702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="713" mass="78610" checksum="9A4751CCDE159DCA" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H173</accession>
    <name>A0AAJ0H173_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chromate transporter-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_498132</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725721.1">
        <property type="nucleotide sequence ID" value="XM_062867305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H173"/>
    <dbReference type="GeneID" id="87886134"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015109">
        <property type="term" value="F:chromate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003370">
        <property type="entry name" value="Chromate_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33567">
        <property type="entry name" value="CHROMATE ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33567:SF3">
        <property type="entry name" value="CHROMATE ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02417">
        <property type="entry name" value="Chromate_transp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="444"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="480"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="517"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="220"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="224"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="250"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="279"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="305"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3309941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="555" mass="60554" checksum="4C1D1E201F4F1FEC" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H1L9</accession>
    <name>A0AAJ0H1L9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_498048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725615.1">
        <property type="nucleotide sequence ID" value="XM_062867299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H1L9"/>
    <dbReference type="GeneID" id="87886128"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3309835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="487" mass="53478" checksum="DC117916AEA91DFA" modified="2024-07-24" version="1">MADQTFVMAATITRSEVNAAGATETSVTTQPSPSLYPQPLTTHHPSMVPVSRQAKIAQPKERSDAVDNPTRPQSPPPPPPPPPLPRLPVTAHTPTETTIINKSRPTHNRNRNRARTPPPPPPSTAPLTPETLHFLLDTFDNALSHTHYAVCGHAALMVWGYRSRPTNNTMPSHVSIVCPAEDKQVILSWARAAGWYVYPKQEEEEEEEEEEEEEEEEEEEEEEEEEEEAPGGGGRGGNGRGSGGEMIGVPVPGSGAATTTTAAATSETVVAFKLRTVENPQVWARLGRVRPLVHVALKQPPPCPYVGSLCEVMPSAAQVMDVPTLLDQFARAWYLCIVKGGEMEGQGSRGRGQQERYIARLILWLLQWLAEDAGDCSTAEGRWRLTAQNVPCVVYGKFRNAFARRYPKAGELLEACGLPTSAHVVAHEETNGADPTVRLCVFDPDAYRMRVARGEGRSRSADEPTVSRPDTLTRAYQDLEFELFSFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H1S5</accession>
    <name>A0AAJ0H1S5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_498399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726031.1">
        <property type="nucleotide sequence ID" value="XM_062867313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H1S5"/>
    <dbReference type="GeneID" id="87886142"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd19817">
        <property type="entry name" value="Bbox1_ANCHR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044553">
        <property type="entry name" value="Bbox1_ANCHR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46603">
        <property type="entry name" value="ABSCISSION/NOCUT CHECKPOINT REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46603:SF1">
        <property type="entry name" value="ABSCISSION_NOCUT CHECKPOINT REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22586">
        <property type="entry name" value="ANCHR-like_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3310251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="395" mass="42251" checksum="B2867242FCD4C2F1" modified="2024-07-24" version="1">MPSPDDQALLDRLSALRPGAAGGISLEKSANAVSPGPKAQPVSREDALAERLRLLRSQQPAKISRDESVSQSTGFPQPPGAPGDEGVGRAGSAPVEPPPGDLSRATKHKAVSKASSVSSPIASQIANQKQDPYWVPEAGADDADAYVELEGFEQEHFDLAADDDTTSNLDSSRDVKVAELLESLQNNPGSSMSQRVEDTSLEDHDDSDGEQMTHAIQAVLSQISDEIKSLPAPPGMLEQGTPSEETGGEQKSFTATSGNESPLALPAVPSQLVDPVFTTEEEGAFEKDISARLASLRGLGSLDELGLPSAPTFRPEDRRTSSTIAGKGLLRSNKYTDEDQTTWCVVCLEDATIRCVGCDNDVYCARCWKEMHVGPSAGYDERGHKWLKFQRRSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H294</accession>
    <name>A0AAJ0H294_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Deoxyuridine 5'-triphosphate nucleotidohydrolase</fullName>
            <shortName evidence="10">dUTPase</shortName>
            <ecNumber evidence="10">3.6.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">dUTP pyrophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0T15DRAFT_40489</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in nucleotide metabolism via production of dUMP, the immediate precursor of thymidine nucleotides, and decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="function">
        <text evidence="2">This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>dUTP + H2O = dUMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10248"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.6.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 10">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the dUTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.23" evidence="10"/>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726293.1">
        <property type="nucleotide sequence ID" value="XM_062865271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H294"/>
    <dbReference type="GeneID" id="87884100"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.40.10:FF:000004">
        <property type="entry name" value="Deoxyuridine triphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00576">
        <property type="entry name" value="dut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001862">
        <property type="entry name" value="PRK00601.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241:SF0">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="dUTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase-like" evidence="12">
        <location>
            <begin position="63"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3310513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="199" mass="20949" checksum="A834DACFF9FDC134" modified="2024-07-24" version="1">MTTDTTSTPNQPIVPTSPPAKRIKTDIGDRANESETMNSSDGAAKQQQEPQSPPLLIKKLSDKARLPTRGSAFAAGYDLYASQDATIPARGKAMVETDISIAVPAGTYGRVAPRSGLAAKHFIDTGAGVIDADYRGPVKILLFNHGETDFEVKEGDRIAQLVIERIYTPEVVEVEELEASVRGAGGFGSTGGFGSAGTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H2A0</accession>
    <name>A0AAJ0H2A0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_41010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726302.1">
        <property type="nucleotide sequence ID" value="XM_062865368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H2A0"/>
    <dbReference type="GeneID" id="87884197"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052400">
        <property type="entry name" value="Zn2-C6_fungal_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657:SF14">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3310522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="526" mass="57190" checksum="EFFBC8B123D98607" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H2Y2</accession>
    <name>A0AAJ0H2Y2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Alpha-mannosidase</fullName>
            <ecNumber evidence="3">3.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_518855</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Degrades free oligosaccharides in the vacuole.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.24" evidence="3"/>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726354.1">
        <property type="nucleotide sequence ID" value="XM_062868393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H2Y2"/>
    <dbReference type="GeneID" id="87887222"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009313">
        <property type="term" value="P:oligosaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10812">
        <property type="entry name" value="GH38N_AMII_ScAms1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.50:FF:000004">
        <property type="entry name" value="alpha-mannosidase 2C1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.110.10:FF:000002">
        <property type="entry name" value="alpha-mannosidase 2C1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.30:FF:000001">
        <property type="entry name" value="alpha-mannosidase 2C1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="entry name" value="Glycoside hydrolase 38, N terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="entry name" value="Glycoside hydrolase family 38, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.30">
        <property type="entry name" value="Golgi alpha-mannosidase II, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054723">
        <property type="entry name" value="Ams1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041147">
        <property type="entry name" value="GH38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46017">
        <property type="entry name" value="ALPHA-MANNOSIDASE 2C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46017:SF1">
        <property type="entry name" value="ALPHA-MANNOSIDASE 2C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22907">
        <property type="entry name" value="Ams1-like_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17677">
        <property type="entry name" value="Glyco_hydro38C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="Families 57/38 glycoside transferase middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 38 central" evidence="10">
        <location>
            <begin position="422"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="834"/>
            <end position="859"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3310574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="987" mass="111937" checksum="47E2D8FD52318593" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H393</accession>
    <name>A0AAJ0H393_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutathione S-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_520090</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726781.1">
        <property type="nucleotide sequence ID" value="XM_062868475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H393"/>
    <dbReference type="GeneID" id="87887304"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00299">
        <property type="entry name" value="GST_C_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF13">
        <property type="entry name" value="GLUTATHIONE TRANSFERASE OMEGA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="27"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="125"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3311001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="293" mass="33421" checksum="1AFC16C5A96E419D" modified="2024-07-24" version="1">MASIDTSLLPQPTGAAAELAARHAAPRPLKLYGGWFCPFVQRAWIVLVEKKIPHQYVEVNPYKKEGELLALNPRGLVPTLSVAHADGGEKRALYESTVICEYLDEAFADEDPYGPRLLPSERREDVFERARCRLWINHIVTKIVPVFYRLLQHTPEKEYPIEEARADFLKGLRDFAQEMLDSAGETLGAADGPWFLGSRFSMVDVMLAPWAKRLFLIDHYKPGGVGIPKKGERGENEEVWARWERWFEAVVNRESVKATWSDDEKYIEAYKRYAEDTTQSQVGQATRQGRSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H3L9</accession>
    <name>A0AAJ0H3L9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Suppressor of anucleate metulae protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_408829</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726978.1">
        <property type="nucleotide sequence ID" value="XM_062865344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H3L9"/>
    <dbReference type="GeneID" id="87884173"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF251">
        <property type="entry name" value="EG:BACR7C10.4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="6">
        <location>
            <begin position="7"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="7">
        <location>
            <begin position="58"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3311198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="578" mass="63714" checksum="3285DF07F9F2CCB0" modified="2024-07-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H449</accession>
    <name>A0AAJ0H449_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_482495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727263.1">
        <property type="nucleotide sequence ID" value="XM_062866108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H449"/>
    <dbReference type="GeneID" id="87884937"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14273">
        <property type="entry name" value="UBA_TAP-C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006577">
        <property type="entry name" value="UAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050730">
        <property type="entry name" value="UBX_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322:SF1">
        <property type="entry name" value="FAS-ASSOCIATED FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322">
        <property type="entry name" value="FAS-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00594">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UAS" evidence="2">
        <location>
            <begin position="183"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3311483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="515" mass="57701" checksum="92382542F34B5FC9" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H482</accession>
    <name>A0AAJ0H482_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0T15DRAFT_520888</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SUN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727030.1">
        <property type="nucleotide sequence ID" value="XM_062868530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H482"/>
    <dbReference type="GeneID" id="87887359"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051526">
        <property type="entry name" value="Beta-Glucosidase_SUN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005556">
        <property type="entry name" value="SUN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31316">
        <property type="entry name" value="BETA-GLUCOSIDASE-LIKE PROTEIN NCA3, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31316:SF0">
        <property type="entry name" value="SECRETED BETA-GLUCOSIDASE SIM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03856">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="106"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="106"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3311250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="423" mass="44328" checksum="A0406A55D34C2E84" modified="2024-07-24" version="1">MKGVIRTAVTAAVIVGVAAQPHNHGHRHLHAKKRDVVVVTEVVEGPTVVKYVTPDGETLDAAQAEADISKGLYYVVGSSLPSFSAPPPAVSTSKASAEFGAQFYEKTTSTSTSTSTSTSTSTSTTTTSAKPSSTKAPTPAQPSATGLDADFPSGDVPCGHVPTEYGAVNIPWLGTAGWTTLAKFGSFIKGVSVDDIESPTSGTCQPGMVCSYACPPGYQKTQWPVEQGARGQSVGGLYCNEKGKLELTRPKYTKLCEPGEGGVYVRNELDSNSAICRTDYPGSEAMVIPIDTQPGNTYPVTNPDQSSYYVWQGKLTTAQYYVNNAGVSVEEACVWKSSLFPDSAGNWAPTNIGVGKAGGVTYLSIFPNKPTTTAKLDFDIAIEVDGKVRSDCWLKSGEYALPDGCTVGVPSGSTATIVLKKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H4A2</accession>
    <name>A0AAJ0H4A2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_68716</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_062871212.1"/>
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    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc finger protein 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000690">
        <property type="entry name" value="Zinc finger protein 354C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
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        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF142">
        <property type="entry name" value="ZINC FINGER PROTEIN 384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
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        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="508"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="536"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="564"/>
            <end position="586"/>
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    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="592"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
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    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="36"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="342"/>
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        </location>
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        <location>
            <begin position="36"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="9">
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
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    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
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    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3311280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="644" mass="70377" checksum="E802107DF5F1AACF" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H4I9</accession>
    <name>A0AAJ0H4I9_9PEZI</name>
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        <submittedName>
            <fullName evidence="8">Binuclear zinc transcription factor</fullName>
        </submittedName>
    </protein>
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        <name evidence="8" type="ORF">B0T15DRAFT_565167</name>
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        <name type="scientific">Chaetomium strumarium</name>
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    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
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                <person name="Cros-Aarteil S."/>
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_062870657.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:DNA binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TF_fung"/>
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        <property type="entry name" value="XnlR_reg_dom"/>
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    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
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    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
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        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3311631.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="532" mass="59273" checksum="135595D71F5363B8" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H4V6</accession>
    <name>A0AAJ0H4V6_9PEZI</name>
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        <submittedName>
            <fullName evidence="9">Permease of the major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_81244</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727404.1">
        <property type="nucleotide sequence ID" value="XM_062871346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H4V6"/>
    <dbReference type="GeneID" id="87890175"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17327">
        <property type="entry name" value="MFS_FEN2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000245">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF1">
        <property type="entry name" value="ALLANTOATE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="464"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="75"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3311624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="523" mass="58143" checksum="1E791D1C2EFBD527" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LXX9</accession>
    <name>A0AAJ0LXX9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_323856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717581.1">
        <property type="nucleotide sequence ID" value="XM_062864084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LXX9"/>
    <dbReference type="GeneID" id="87882913"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3301801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="168" mass="19263" checksum="FC99A302AC556AAA" modified="2024-07-24" version="1">MLSQHGSIGLDQYMAVLDLASVYARKYLAYGLYDTGYTRLITLAPLYWRQLNLLYDICSNPSLYLSDDIRVSLGSYRPPNRELDVAVKRVMLLGVAKTVRERVEEIQERVEGFEDRIARGSLELAEAGRLNLQWLLGVIWNLTRRLDTIKAVLEKEDWGLIAEAMPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LY37</accession>
    <name>A0AAJ0LY37_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Oxidoreductase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_544913</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717658.1">
        <property type="nucleotide sequence ID" value="XM_062870110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LY37"/>
    <dbReference type="GeneID" id="87888939"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3301878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="32785" checksum="EFF065DD1EC26696" modified="2024-07-24" version="1">MAPLVWLITGCSSGFGAQFVHSALARGDKVIATGRNAATKLKHLEGTGASIVDLDVTLPEDDVKEIVDRAVKIHGRIDVLVNNAGYGVFGAMEETSNEDYKKLFNVNVFGALSVTRAVLPYMRAQQSGTVAFVGSMYAWWTPGMVSVYGAAKGALRAIVDSLAAELAPFNIRTIDFEPGYFQTPLTDVAKLSQYASTKPPMDAYAAHRAAIVAVSEVMDGNERGDVKKGVELMVDVIRGEGCASGRKLPPRLPIGYDAVKVIEGACSNILKVIDVWRSDIVGTTDRDEFKGGDLIESVSTVPEVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717885.1">
        <property type="nucleotide sequence ID" value="XM_062869900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LYA3"/>
    <dbReference type="GeneID" id="87888729"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42084:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PPK6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42084">
        <property type="entry name" value="YALI0E26631P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="9"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
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        </location>
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            <begin position="13"/>
            <end position="25"/>
        </location>
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            <begin position="33"/>
            <end position="78"/>
        </location>
    </feature>
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        </location>
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        </location>
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        </location>
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            <end position="290"/>
        </location>
    </feature>
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            <begin position="347"/>
            <end position="373"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3302105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="637" mass="68699" checksum="9C38914CB377B105" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LYV3</accession>
    <name>A0AAJ0LYV3_9PEZI</name>
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        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062863972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LYV3"/>
    <dbReference type="GeneID" id="87882801"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024368">
        <property type="entry name" value="Ecl1/2/3"/>
    </dbReference>
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        <property type="entry name" value="ULD_fung"/>
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        <property type="entry name" value="Ecl1"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <end position="263"/>
        </location>
    </feature>
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    </feature>
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            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="406"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3302777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="475" mass="53548" checksum="60F0221C949F032B" modified="2024-07-24" version="1">MASPLSVGDCIAIIGVIVKCVDAVCGSSDDAKALEGLKGDLAHMRESLEELLSPSSAWCSASHATLGRLNSTIDRCRDALRELATLTEKYGPRKSRFATFYSQITWAISGKTKVAPIQCRIQNLTAALLLIQGDIIRQTIDDLGASGERGNRRLARQLHQSKEEVKYHIYAAIDEPWDQKPIRFQDAMGRRFPVPLEICRRFSDFLEFLAFSFKGHDLLPFVAHKNIWLFTPSENGSRWWYLIHEGDWAAAARPGVKLGMSIFREHVWQPPNMYSSISLSRPIPPWSTLPENLEFRWWSQPPLSGPISMEEPRRDPTIDPISDKSGPDQGRDPLCEGPAVGMESETIGRPTSKVGLDPRVHQAFLRCLRVEDLNPYQFCLACDKQIVGAAYCSKSCKLSNWSITGKHHDQNPRLSRTLDTRNENDDNPRAESEGDFDRNFDVDSDLGLGWDSDFECEFDWREFCDGSDTGDWPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LYV4</accession>
    <name>A0AAJ0LYV4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_562614</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Sordariomycetes</taxon>
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            <taxon>Chaetomiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718438.1">
        <property type="nucleotide sequence ID" value="XM_062870586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LYV4"/>
    <dbReference type="GeneID" id="87889415"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF54">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="176"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3302658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="603" mass="64088" checksum="6094143996E0E147" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LYV8</accession>
    <name>A0AAJ0LYV8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphatidic acid phosphatase type 2/haloperoxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_543613</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718453.1">
        <property type="nucleotide sequence ID" value="XM_062870008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LYV8"/>
    <dbReference type="GeneID" id="87888837"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03398">
        <property type="entry name" value="PAP2_haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.606.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052559">
        <property type="entry name" value="V-haloperoxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34599">
        <property type="entry name" value="PEROXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34599:SF2">
        <property type="entry name" value="TRAF-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042556348" evidence="1">
        <location>
            <begin position="18"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="2">
        <location>
            <begin position="261"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3302673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="419" mass="45195" checksum="B957CA9BF083647D" modified="2024-07-24" version="1">MKLSVLSLATAAAVVNAAYSGDIVYYWVDQSASFVNGTIIGGLQSPPSAWAQAIVQAAVYKAAVESRQESLEFQQLAVSHAAHNSLLWVFHGSRLYNAVDAALRAVIPAIGLDPGSTKGKKAARVGQEAAAKVASARADDKLTNFVDFTYGPREPGVYQQTPGSNPLPDTPQARFVAPFAGLGDISRFRAPPPPKTNSKEYEADALYVKEQGSLNSTVRSAYDTDTAYFWRESSITAWNRFAGAIIGEKYATKPVDSAKFYAQLNYALANAGFASWDTKYAYQGWRPVTAIQYPGIWVASGRDISDPSWTPLLRPTPSHPDYVSTHATFGGAASAVLRSAWNGGRDGINATVLSSNVTIDGRGVISRTFTSLRAAAEENARSRVFGGIHFSFAGREGIALGERVAKETLDKFDENWEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LYX0</accession>
    <name>A0AAJ0LYX0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Peptidase S8/S53 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0T15DRAFT_314817</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718559.1">
        <property type="nucleotide sequence ID" value="XM_062863971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LYX0"/>
    <dbReference type="GeneID" id="87882800"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02124">
        <property type="entry name" value="PA_PoS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07489">
        <property type="entry name" value="Peptidases_S8_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1710">
        <property type="entry name" value="Subtilisin-like superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010435">
        <property type="entry name" value="C5a/SBT2-like_Fn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034187">
        <property type="entry name" value="Peptidases_S8_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF66">
        <property type="entry name" value="SERIN ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06280">
        <property type="entry name" value="fn3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042512850" evidence="10">
        <location>
            <begin position="20"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="11">
        <location>
            <begin position="145"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="12">
        <location>
            <begin position="361"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="C5a peptidase/Subtilisin-like protease SBT2-like Fn3-like" evidence="13">
        <location>
            <begin position="603"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="892"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7 8">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7 8">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7 8">
        <location>
            <position position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3302779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="915" mass="96140" checksum="E42304ACC40AF015" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZ40</accession>
    <name>A0AAJ0LZ40_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial</fullName>
            <shortName evidence="7">Glu-AdT subunit B</shortName>
            <ecNumber evidence="7">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_495616</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-glutamyl-tRNA(Gln) + L-glutamine + ATP + H2O = L-glutaminyl-tRNA(Gln) + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A, B and C subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GatB/GatE family. GatB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="7"/>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718827.1">
        <property type="nucleotide sequence ID" value="XM_062867116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZ40"/>
    <dbReference type="GeneID" id="87885945"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070681">
        <property type="term" value="P:glutaminyl-tRNAGln biosynthesis via transamidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00121">
        <property type="entry name" value="GatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017959">
        <property type="entry name" value="Asn/Gln-tRNA_amidoTrfase_suB/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006075">
        <property type="entry name" value="Asn/Gln-tRNA_Trfase_suB/E_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018027">
        <property type="entry name" value="Asn/Gln_amidotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004413">
        <property type="entry name" value="GatB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017958">
        <property type="entry name" value="Gln-tRNA_amidoTrfase_suB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00133">
        <property type="entry name" value="gatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004012">
        <property type="entry name" value="PRK05477.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659">
        <property type="entry name" value="GLUTAMYL-TRNA GLN AMIDOTRANSFERASE SUBUNIT B MITOCHONDRIAL AND PROKARYOTIC PET112-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659:SF0">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02934">
        <property type="entry name" value="GatB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02637">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00845">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="GatB/YqeY motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01234">
        <property type="entry name" value="GATB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asn/Gln amidotransferase" evidence="9">
        <location>
            <begin position="445"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="35"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3303047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="628" mass="69018" checksum="70FE0E9AED063041" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZ91</accession>
    <name>A0AAJ0LZ91_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Concanavalin A-like lectin/glucanase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_539256</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718905.1">
        <property type="nucleotide sequence ID" value="XM_062869723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZ91"/>
    <dbReference type="GeneID" id="87888552"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070007">
        <property type="term" value="F:glutamic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13426">
        <property type="entry name" value="Peptidase_G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.700">
        <property type="entry name" value="Peptidase G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000250">
        <property type="entry name" value="Peptidase_G1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038656">
        <property type="entry name" value="Peptidase_G1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536:SF1">
        <property type="entry name" value="ASPERGILLOPEPSIN, PUTAITVE (AFU_ORTHOLOGUE AFUA_7G01200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01828">
        <property type="entry name" value="Peptidase_A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00977">
        <property type="entry name" value="SCYTLDPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042511866" evidence="2">
        <location>
            <begin position="21"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600250-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3303125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="277" mass="29487" checksum="4291784CFCAF8ACB" modified="2024-07-24" version="1">MRFTLAALLGSALVARQALAELTFTVAATKDGVPIPQSEIKLEPMEFGTGRVGHATPAQGHRRFRRANAAATSANWCGAVNTASSSNQIKVVHASFQHPSCSTRTGATYPQAAAAWAGIDGDSHTSALLQAGTVCKIDNSTGIVRHEAWWQWVPEAANTVTSLPVAPHDYIEITINTNSTTAAEITLTNVSKGYTYTVSIRDGPALARVDADWVVERPYYGATLAGFPTFTDVWFDEAYATRVSGANLGVLGSKQYQIPNLCASIEDGDAAQVSWSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZ99</accession>
    <name>A0AAJ0LZ99_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_560112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718991.1">
        <property type="nucleotide sequence ID" value="XM_062870523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZ99"/>
    <dbReference type="GeneID" id="87889352"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="77"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3303211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="646" mass="71994" checksum="624F2B73A0669150" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZF0</accession>
    <name>A0AAJ0LZF0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Natural resistance-associated macrophage protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_271343</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719114.1">
        <property type="nucleotide sequence ID" value="XM_062863463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZF0"/>
    <dbReference type="GeneID" id="87882292"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015086">
        <property type="term" value="F:cadmium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034755">
        <property type="term" value="P:iron ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001046">
        <property type="entry name" value="NRAMP_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01197">
        <property type="entry name" value="nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037982">
        <property type="entry name" value="Nramp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706:SF101">
        <property type="entry name" value="MANGANESE TRANSPORTER SMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706">
        <property type="entry name" value="SOLUTE CARRIER PROTEIN FAMILY 11 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01566">
        <property type="entry name" value="Nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00447">
        <property type="entry name" value="NATRESASSCMP"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="136"/>
            <end position="155"/>
        </location>
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            <begin position="175"/>
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        </location>
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            <end position="242"/>
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            <end position="350"/>
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        <source>
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        <source>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
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                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
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                <person name="Chen C."/>
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                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
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                <person name="Ament-Velasquez S.L."/>
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                <person name="Powell A.J."/>
                <person name="Barry K."/>
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                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Kuo A."/>
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                <person name="Labutti K."/>
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                <person name="Ament-Velasquez S.L."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </evidence>
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            <dbReference type="EMBL" id="KAK3303542.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </organism>
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            <strain evidence="7">CBS 333.67</strain>
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                <person name="Labutti K."/>
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                <person name="Steindorff A."/>
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                <person name="Natvig D."/>
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                <person name="Grigoriev I.V."/>
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                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M059</accession>
    <name>A0AAJ0M059_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAK3304023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062862895.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87881724"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042515242" description="Secreted protein" evidence="1">
        <location>
            <begin position="31"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3304023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="85" mass="9351" checksum="13EA395694C92294" modified="2024-07-24" version="1">MLGSQGPKDITKTTVLLIQLFLSSIPCSGGSVHYPGADTPTKSSTFMLRVRCVHPFHSRFHPKKIPRRSLVGRCQSANVIVWNCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M0H2</accession>
    <name>A0AAJ0M0H2_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Mus7/MMS22 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_400639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720237.1">
        <property type="nucleotide sequence ID" value="XM_062865074.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87883903"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035361">
        <property type="term" value="C:Cul8-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019021">
        <property type="entry name" value="Mms22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28122">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SUBSTRATE RECEPTOR MMS22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28122:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SUBSTRATE RECEPTOR MMS22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09462">
        <property type="entry name" value="Mus7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="629"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="721"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="865"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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    </feature>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="757"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3304457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="2189" mass="242501" checksum="6145B5F6182FDAFC" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ0M0P9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein-serine/threonine kinase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_247918</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ATP = O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23052"/>
            <dbReference type="Rhea" id="RHEA-COMP:13689"/>
            <dbReference type="Rhea" id="RHEA-COMP:13690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="8"/>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720373.1">
        <property type="nucleotide sequence ID" value="XM_062863137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M0P9"/>
    <dbReference type="GeneID" id="87881966"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16929">
        <property type="entry name" value="HATPase_PDK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000065">
        <property type="entry name" value="[Pyruvate dehydrogenase (Acetyl-transferring)] kinase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF3">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="306"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3304593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="440" mass="50543" checksum="17868CEE0B67F54D" modified="2024-07-24" version="1">MSWKRSEKLMDTIRHYASFPATGVSLRQMVQFGEKPSTGTLFRASQFLAEELPIRLAHRVQELETLPDGLNEMPSVKKVADWYAQSFEELTTFPRPELPRDVRERLMRPAKMAGKSNSWLSEATPNPSIEEGQYSSWNGSNNNNNGWAKGRFPTTRRYFAMVDDTGDWPPELQLYNQKFAQTLHRIKRRHDSVVTTMAQGILEWKRRRQRMLIDNNIQSFLDRFYMSRIGIRMLIGQHIALTDQSHYRDPSYVGIICTKTYVKELAQEAIENARFVCEDHYGLFEAPKIQLVCDPNLNFMYVPGHLSHMLFETLKNSLRAVVETHGQDKQEFPVTKVIVAEGKEDITIKISDEGGGIPRSAIPLVWTYMYTTVDRTPNLDPDFDKSDFKAPMAGFGYGLPISRLYARYFGGDLKLISMEGYGTDVYLHLNRLSSSSEPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M0S7</accession>
    <name>A0AAJ0M0S7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_558763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720552.1">
        <property type="nucleotide sequence ID" value="XM_062870484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M0S7"/>
    <dbReference type="GeneID" id="87889313"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042465598" evidence="1">
        <location>
            <begin position="19"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3304772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="265" mass="28994" checksum="51AEFD028123B057" modified="2024-07-24" version="1">MPSSIKVFAALLGTTALARPNPTPPLPSNPVRILPYNWKYEIIALQGPGCPDAGPNSPEDYYHTRPTFGSNTVDGSEIYYWHFAYPHMRLAVEASSSSSSSSSSSIWCETTLRYTELTKTGAAPPAVPEYRLRLHKNGTAMIAAYELDAGVEAKWTFTYYHPTTDRDDGETEKLKKEPIVDTITVAGPRAAGTYTDVSVEGGLVQYPLPECGEGIIKYRTELTVKATKSGARGVVASEAYEREGKGKEYYGVQQGVSYDWEKCAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M1B8</accession>
    <name>A0AAJ0M1B8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="14">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0T15DRAFT_531933</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol III by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="14"/>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721092.1">
        <property type="nucleotide sequence ID" value="XM_062869285.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87888114"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
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        <property type="entry name" value="RPC1"/>
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    </dbReference>
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        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
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    </dbReference>
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        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="263"/>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ0M206_9PEZI</name>
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        <lineage>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="protein sequence ID" value="KAK3306110.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062869434.1"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="P68_RBP_TagC-like_beta-prop"/>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042467162" description="P68 RBP/TagC-like beta-propeller domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="P68 RBP/TagC-like beta-propeller" evidence="2">
        <location>
            <begin position="47"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3306110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M2E7</accession>
    <name>A0AAJ0M2E7_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_140069</name>
    </gene>
    <organism evidence="2 3">
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
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                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722218.1">
        <property type="nucleotide sequence ID" value="XM_062861869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M2E7"/>
    <dbReference type="GeneID" id="87880698"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125:SF12">
        <property type="entry name" value="AT HOOK TRANSCRIPTION FACTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR48125">
        <property type="entry name" value="LP07818P1"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="207"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="394"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="462"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1079"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1114"/>
            <end position="1129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3306438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1129" mass="122699" checksum="41085F1FFBDFD242" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M2I2</accession>
    <name>A0AAJ0M2I2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="14">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B0T15DRAFT_150032</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 14">Membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="14"/>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722471.1">
        <property type="nucleotide sequence ID" value="XM_062861981.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87880810"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006892">
        <property type="term" value="P:post-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF174">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE DNF3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 13 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="363"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1213"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1247"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1276"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1320"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="17">
        <location>
            <begin position="76"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="16">
        <location>
            <begin position="206"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="18">
        <location>
            <begin position="1099"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="544"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1420"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="1424"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="11">
        <location>
            <position position="473"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="473"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="473"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="475"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="475"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="622"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="667"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="690"/>
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        <source>
            <dbReference type="Pfam" id="PF16212"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3306691.1"/>
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    </evidence>
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        <source>
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    <sequence length="1440" mass="160259" checksum="809EE0AD7770727A" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M2K0</accession>
    <name>A0AAJ0M2K0_9PEZI</name>
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    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
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                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
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                <person name="Powell A.J."/>
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                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
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                <person name="Hiltunen Thoren M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="7">CBS 333.67</strain>
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        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
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                <person name="Ament-Velasquez S.L."/>
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                <person name="Powell A.J."/>
                <person name="Barry K."/>
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                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="nucleotide sequence ID" value="XM_062861989.1"/>
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    <dbReference type="GeneID" id="87880818"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="F:FAD binding"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
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        <property type="entry name" value="FAD/NAD-bd_sf"/>
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        </location>
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    </feature>
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            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
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            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="KAK3306710.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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            <taxon>Sordariomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724004.1">
        <property type="nucleotide sequence ID" value="XM_062861367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M491"/>
    <dbReference type="GeneID" id="87880196"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF13">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="421"/>
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        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
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        </location>
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    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="480"/>
            <end position="510"/>
        </location>
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    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="545"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="82"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="8">
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="8">
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            <begin position="592"/>
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        </location>
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        <source>
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        <source>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
    <sequence length="794" mass="85378" checksum="050248605D13B7B8" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M4E6</accession>
    <name>A0AAJ0M4E6_9PEZI</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">B0T15DRAFT_550439</name>
    </gene>
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        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
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                <person name="Westerberg I."/>
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                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <location>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3308390.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ0M4M6_9PEZI</name>
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        <submittedName>
            <fullName evidence="8">Eukaryotic rRNA processing protein EBP2-domain-containing protein</fullName>
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        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
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                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
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    <comment type="similarity">
        <text evidence="2">Belongs to the EBP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062861628.1"/>
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    <dbReference type="GeneID" id="87880457"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:rRNA processing"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Ebp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13028">
        <property type="entry name" value="RRNA PROCESSING PROTEIN EBNA1-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13028:SF0">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EBP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05890">
        <property type="entry name" value="Ebp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
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            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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            <end position="439"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="217"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="273"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="132"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007336"/>
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                <person name="Bonometti L."/>
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                <person name="Guillou S."/>
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
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                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
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                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
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        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Bonometti L."/>
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                <person name="Cros-Aarteil S."/>
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
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                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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    </reference>
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        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <evidence type="ECO:0000313" key="2">
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Grigoriev I.V."/>
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    <reference evidence="2" key="2">
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                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
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                <person name="Ng V."/>
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                <person name="Steindorff A."/>
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                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
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                <person name="Hutchinson M.I."/>
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                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M6F2</accession>
    <name>A0AAJ0M6F2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">F-actin-capping protein subunit beta</fullName>
        </recommendedName>
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    <gene>
        <name evidence="12" type="ORF">B0T15DRAFT_519008</name>
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    <organism evidence="12 13">
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 10">F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the F-actin capping complex, composed of a heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Actin patch</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the F-actin-capping protein beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726419.1">
        <property type="nucleotide sequence ID" value="XM_062868411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M6F2"/>
    <dbReference type="GeneID" id="87887240"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008290">
        <property type="term" value="C:F-actin capping protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.570:FF:000001">
        <property type="entry name" value="F-actin-capping protein subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.210:FF:000005">
        <property type="entry name" value="F-actin-capping protein subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.210">
        <property type="entry name" value="F-actin capping protein, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037282">
        <property type="entry name" value="CapZ_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042276">
        <property type="entry name" value="CapZ_alpha/beta_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001698">
        <property type="entry name" value="CAPZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043175">
        <property type="entry name" value="CAPZB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019771">
        <property type="entry name" value="F-actin_capping_bsu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10619">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10619:SF0">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT BETA ISOFORMS 1 AND 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01115">
        <property type="entry name" value="F_actin_cap_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00192">
        <property type="entry name" value="FACTINCAPB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90096">
        <property type="entry name" value="Subunits of heterodimeric actin filament capping protein Capz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00231">
        <property type="entry name" value="F_ACTIN_CAPPING_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0117">Actin capping</keyword>
    <keyword evidence="6 10" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="74"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3310639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="286" mass="31443" checksum="5F920D697C58D055" modified="2024-07-24" version="1">MATADPFDSALDLLRRLNPKHTAEHLNNIITIAPDLTEDLLSSVDQPLTVRRCKQTGRDYLLCDYNRDGDSYRSPWSNQFDPPLDEAGGLGGVGAGGSNEGAGEGAVPGERVRKMEIKANEAFDVYRELYYEGGVSSVYLWNLDDGFAGVVLLKKASPQNDGSSSGVWDSIHVFEASERGRTSNYRLTSTVILSLATKGAALGEVDLSGNMTRQVEQDLPVENDESHIANIGRLVEDMELKMRNLLQEVYFGKAKDVVGDLRSIGSLSEGQRDRETQRELIGSMRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M6J6</accession>
    <name>A0AAJ0M6J6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidylinositol 3-kinase VPS34</fullName>
            <ecNumber evidence="7">2.7.1.137</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0T15DRAFT_519427</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12709"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.137"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:12710"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.137" evidence="7"/>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726554.1">
        <property type="nucleotide sequence ID" value="XM_062868429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M6J6"/>
    <dbReference type="GeneID" id="87887258"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016303">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08397">
        <property type="entry name" value="C2_PI3K_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00870">
        <property type="entry name" value="PI3Ka_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00896">
        <property type="entry name" value="PI3Kc_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000002">
        <property type="entry name" value="Phosphatidylinositol 3-kinase catalytic subunit type 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000002">
        <property type="entry name" value="Phosphatidylinositol 3-kinase catalytic subunit type 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.70:FF:000009">
        <property type="entry name" value="Phosphatidylinositol 3-kinase VPS34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000238">
        <property type="entry name" value="Phosphatidylinositol 3-kinase VPS34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057756">
        <property type="entry name" value="PI3-kinase_type3/VPS34_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002420">
        <property type="entry name" value="PI3K-type_C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008290">
        <property type="entry name" value="PI3K_Vps34"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF7">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00792">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000587">
        <property type="entry name" value="PI3K_Vps34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00142">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00145">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51547">
        <property type="entry name" value="C2_PI3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="C2 PI3K-type" evidence="11">
        <location>
            <begin position="12"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="PIK helical" evidence="10">
        <location>
            <begin position="352"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="9">
        <location>
            <begin position="619"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="152"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3310774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="903" mass="102291" checksum="615983F0B6294281" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M760</accession>
    <name>A0AAJ0M760_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_482417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727170.1">
        <property type="nucleotide sequence ID" value="XM_062866100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M760"/>
    <dbReference type="GeneID" id="87884929"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF185">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_3G02360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3311390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="422" mass="44631" checksum="8F794DDB678DF78B" modified="2024-07-24" version="1">MASSTVILGAGIIGVSTAYYLSQHQDPSSIHLVEPSPELFSSASGYAGGFLAKDWFAPSVSALGALSFEEHRRLAEEHGGREKWGYSPATCVSYAASAAARDSQKRGDDWLRDGTSRADAAPVVLDSSSGKTPTWLRRVDGDHIELISDEDTTAQVDPLLLCQFLLQECVKRGVKLHHPAKPVSVGTGGKGALAAVRIVDTKTSAETTLECTRLIITAGAWTGQVFQTLFPRSKLQLPIKSLAGHSLMLKSPRWHAGLEHNGCHAIFTTHQTAFCPEMFSRLGGHIYFAGLNSSTLPLPDAAAGKATPYSDSLVQLREAAKEILGSGPGAEDDLEIVREGLCFRPVTPWGSPIVSRIRDQDLGLGTATRPGAEGGVYIAAGHGPWGIAMSLGTGIVLAEMVQGRKLSADVSGLGIRGEGAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M7D8</accession>
    <name>A0AAJ0M7D8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_549305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727410.1">
        <property type="nucleotide sequence ID" value="XM_062870215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M7D8"/>
    <dbReference type="GeneID" id="87889044"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053018">
        <property type="entry name" value="Elsinochrome_Biosynth-Asso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37577">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37577:SF1">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3311630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="311" mass="34629" checksum="55BBDB94D7E61724" modified="2024-07-24" version="1">MATCAEFEFQKCGFERGVVKANPDIAGIGIILSFLVTTSVTVLAGFYRILFDFITEFFLTPYQQDIVRFPSGDGWLWVNPGFWARVVDRLLLALNDSQLFTGTAVQVASLVQHCEITIYHLRIVAELAFLSTVTHLLTVVAMSGYFIDNAGSNTPRVLVMLLNLGLLGYTTWFAYLYEAASPFDESLQLGCYYAGYRPPVVASFTVRWTLLLLAAVLGHLVVFLAMYWKGFRTWIAGTRGAALRFFRTAILVPAYTIYGLVSSSRVLRQTQALGTPPVDIEGSEREWGFGQILALLLLALIVLPGWDSFME</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GKT7</accession>
    <name>A0AAJ0GKT7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Indoleamine 2,3-dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_514989</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the indoleamine 2,3-dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717518.1">
        <property type="nucleotide sequence ID" value="XM_062868152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GKT7"/>
    <dbReference type="GeneID" id="87886981"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033754">
        <property type="term" value="F:indoleamine 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000898">
        <property type="entry name" value="Indolamine_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657:SF10">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01231">
        <property type="entry name" value="IDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00876">
        <property type="entry name" value="IDO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="309"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="418"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="309"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="322"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="binding site" description="proximal binding residue" evidence="4">
        <location>
            <position position="388"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600898-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3301738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="473" mass="51585" checksum="FEB0462B8526ED28" modified="2024-07-24" version="1">MSPCETLTLPSKGAVPGALPVSLEEYGVSTNGFLPSEPPLERLPNPYYSPWESLIASLPTLLEQQTFRSQVDRLPILSTEHLSSEQEWRRACVVLGFLAHAYIWGGETPAEILPPPITIPFLAASSHLGIPPVASYACLNLWNFRSASLNPANLDSLHALHTFTGTEDESWFYMVSVAMEAQGGYIIPVMLHALESLHHHHHPEQQSPAVYNTTIASLDELTSCIGTLGKLLDRMDERCRPPVFYHRIRPFLAGSKNMSAAGLPRGVFYDEGDNGGRKGEWRELRGGSNGQSSLIQFLDLVLGVEHAVQGNSGPEQKQSQSRRGDGAGKEGRRMGRYPGGMRAGVSRLLGLEEVGEGEGGGGLRQQQLAVREAFQTATKALAEFRNKHLQLVTRYIIIPSRQPNGCTGLNLATVSSKLRSEPGVEGRQGSTPKARGELTGTGGTELLPFLKQSRDETFQAGQLQVRKVLSVEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GLM7</accession>
    <name>A0AAJ0GLM7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-mRNA-splicing factor 18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_487404</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PRP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717962.1">
        <property type="nucleotide sequence ID" value="XM_062866433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GLM7"/>
    <dbReference type="GeneID" id="87885262"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071021">
        <property type="term" value="C:U2-type post-spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.940.10:FF:000008">
        <property type="entry name" value="Related to potassium channel regulatory factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.110">
        <property type="entry name" value="Pre-mRNA processing factor 4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004098">
        <property type="entry name" value="Prp18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014906">
        <property type="entry name" value="PRP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036285">
        <property type="entry name" value="PRP4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039979">
        <property type="entry name" value="PRPF18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13007">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13007:SF19">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02840">
        <property type="entry name" value="Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08799">
        <property type="entry name" value="PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47938">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158230">
        <property type="entry name" value="PRP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA processing factor 4 (PRP4)-like" evidence="10">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Prp18" evidence="9">
        <location>
            <begin position="220"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="62"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3302182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="367" mass="41614" checksum="C08A82B9BEE36EC7" modified="2024-07-24" version="1">MDFAALLAKELDKAKPPAPSSSSSAPKYISRREAEEARKAAYLAEQKRLEEERAAKAAAKRKREEEAEQEKREREEKRARLAEESRRRREAKEAEEERARRKRLGLPELPPSREGSESAAKVEEEEDDELDGEGKETDIVEEELVKKLRDLGEPAVLFGEDHAARVKRYWKTARGGSVAATGPIATTLAPVEEKDMKVPDKVPPASDKKARRFLFRQLASYFNMVLREWDAALVREDNADTFAGQAARNAMVSSKETMKPLFRKFEQGDLDESVLEAIVEIVKAAQERRYVDANDGYLRLSIGKAAWPIGVTMVGIHERSAREKLHDGERGHIMGSEVTRKYLQSIKRCLTFAQVRWPPEDVRQLMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GLN8</accession>
    <name>A0AAJ0GLN8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_487433</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717998.1">
        <property type="nucleotide sequence ID" value="XM_062866437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GLN8"/>
    <dbReference type="GeneID" id="87885266"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001317">
        <property type="entry name" value="Putative ADP-ribosylation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45909">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45909:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="144"/>
            <end position="147"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3302218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="213" mass="23822" checksum="26256505D73CDD61" modified="2024-07-24" version="1">MYHLAKGLYRLATSKEEYSVLLLGLDNAGKTTFHEQVKSIFLPDNPSPKLKTVPTVGQNVSTIILPDMYLKIWDVGGQLSLRKLWQSYYASCHAIVFIIDSTDIGDGSLDHDDSSGRLEECRLVLEDVLQNSEAEGVPLLILANKQDREDCVEVVRIKEGLVKRVFEGEKAGGIRDSRVLPVSALTGTGVREAVDWVRSRVKWNKESRPPVMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GMC4</accession>
    <name>A0AAJ0GMC4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_569757</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718384.1">
        <property type="nucleotide sequence ID" value="XM_062870813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GMC4"/>
    <dbReference type="GeneID" id="87889642"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000247">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000106">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF29">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="438"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="469"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="505"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3302604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="562" mass="64330" checksum="A0E3B7E2B0E44CD0" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GMP3</accession>
    <name>A0AAJ0GMP3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">chitinase</fullName>
            <ecNumber evidence="4">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B0T15DRAFT_423165</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="4"/>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718591.1">
        <property type="nucleotide sequence ID" value="XM_062865586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GMP3"/>
    <dbReference type="GeneID" id="87884415"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00035">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001002">
        <property type="entry name" value="Chitin-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018371">
        <property type="entry name" value="Chitin-binding_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF333">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00187">
        <property type="entry name" value="Chitin_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00270">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00026">
        <property type="entry name" value="CHIT_BIND_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50941">
        <property type="entry name" value="CHIT_BIND_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="6 12" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042614941" description="chitinase" evidence="14">
        <location>
            <begin position="21"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="15">
        <location>
            <begin position="20"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="16">
        <location>
            <begin position="114"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="51"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK3302811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1138" mass="127184" checksum="267A20EF23230D12" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GN17</accession>
    <name>A0AAJ0GN17_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-L-isoaspartate(D-aspartate) O-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.77</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_260287</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.77" evidence="3"/>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3302977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718757.1">
        <property type="nucleotide sequence ID" value="XM_062863321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GN17"/>
    <dbReference type="GeneID" id="87882150"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004719">
        <property type="term" value="F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity"/>
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                <person name="Kuo A."/>
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                <person name="Labutti K."/>
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                <person name="Steindorff A."/>
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                <person name="Martin F."/>
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                <person name="Ament-Velasquez S.L."/>
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                <person name="Grigoriev I.V."/>
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                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Hensen N."/>
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                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
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    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GeneID" id="87882434"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="EMBL" id="KAK3303731.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GPM6</accession>
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        <submittedName>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719587.1">
        <property type="nucleotide sequence ID" value="XM_062870802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GPM6"/>
    <dbReference type="GeneID" id="87889631"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38846">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38846:SF1">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3303807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="172" mass="19686" checksum="0306594FA481F42F" modified="2024-07-24" version="1">MSRLVADEGDFEPPPASQSHFARFKNFTPNDEASFDEEFARLAAPRSTHLTEEELELKGYQDLCREVGIEPSESVAECKRLLKTKLVNIIDLIDARRNGNEVKVWDDFDAFRDYTLNDDEKRIDIEEAKGTHLESLLQRLITGPCSRRKRRAKRRGRGKGVASGRINKQRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GPN0</accession>
    <name>A0AAJ0GPN0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_577076</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719599.1">
        <property type="nucleotide sequence ID" value="XM_062871052.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87889881"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF72">
        <property type="entry name" value="OSMOSENSING HISTIDINE PROTEIN KINASE SLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="600"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="1159"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="295"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="378"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1041"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1100"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1118"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="1210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3303819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1286" mass="138896" checksum="7897876865BE6FC3" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GPU9</accession>
    <name>A0AAJ0GPU9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nucleoside phosphorylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_496245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719495.1">
        <property type="nucleotide sequence ID" value="XM_062867166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GPU9"/>
    <dbReference type="GeneID" id="87885995"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="2">
        <location>
            <begin position="85"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3303715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="905" mass="102264" checksum="BB83E481ECE5ADD2" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQ60</accession>
    <name>A0AAJ0GQ60_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD dependent oxidoreductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_503233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3303880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719660.1">
        <property type="nucleotide sequence ID" value="XM_062867465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQ60"/>
    <dbReference type="GeneID" id="87886294"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF26">
        <property type="entry name" value="FMN REDUCTASE LOT6, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G06600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042556480" evidence="1">
        <location>
            <begin position="30"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3303880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="467" mass="52139" checksum="8EFEBFDA317EA335" modified="2024-07-24" version="1">MHVSHRPLPRLKLLTFSFLAWTSIHTAYASNVLERDIAIIGGGASGVYAALRLREMNHSFAIVEERDHFGGHVSTYTVPGTETHIDYGAQGFGGDEDSIRRFFGYYDIPLVRVKLAEVGFGKTRYVDFKTSTELPDFRPDQNISVLAREVYKYPELSLNTALPSPLPEDLALTFRDFVTKYGIESSVFSIYFQTEGLGDLLSKPTLYVFKYLNPAYLDGQLPTSPGFFVTERAFNQEVYLRAQADFGASALVSSRVVAAQRNDSRVVLVVKTPTRTQTIVARKLLVTMPPTLANMRPLDLDAREHGLFSRFEAQGWYVGLVNATGFVAGHEFINAAAAHSQFHLPQLPALYQISPTRVEGIHLVRYGSPSYMTESDVRADIVRTVDRVRRAVVPNAASLPSVELLAFSSHWPFSLRVSASDMAGGFYTRLDALQGHRSTWYTGATFSSTTASHVWNFTERLLPRVFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQ84</accession>
    <name>A0AAJ0GQ84_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_229023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719851.1">
        <property type="nucleotide sequence ID" value="XM_062862920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQ84"/>
    <dbReference type="GeneID" id="87881749"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3304071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="245" mass="24475" checksum="B2651108CA025B1C" modified="2024-07-24" version="1">MAATLGFVSFGAQDNDLRPAKKRRFNPQSGSAIIADDASRSMEATAESTSTLAGYHKAQLPSSKRTKPATTDEITYSDSDDGTGKGDNANKNDDDFELDLDPGAPPSPSAEGTSTRTPAAAVGAVDAGGPTPTSASASASTSGPFQPSARGGRGGGRGGGVRDGGAGGGGGGANPQWYIDYYDPSSNENPWEGMEKFKGLEPVGTWLPSRWASSNDAAGVGAARQEVGAGAGGEGTVLASTATAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQY1</accession>
    <name>A0AAJ0GQY1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Genetic interactor of prohibitins 3, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_244046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720293.1">
        <property type="nucleotide sequence ID" value="XM_062863101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQY1"/>
    <dbReference type="GeneID" id="87881930"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050896">
        <property type="entry name" value="Mito_lipid_metab_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46434">
        <property type="entry name" value="GENETIC INTERACTOR OF PROHIBITINS 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46434:SF1">
        <property type="entry name" value="GENETIC INTERACTOR OF PROHIBITINS 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="682"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="692"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3304513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="717" mass="79954" checksum="09D1354B1BC7C90C" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GR95</accession>
    <name>A0AAJ0GR95_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="9">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_241937</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Esterase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the carbohydrate esterase 1 (CE1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="9"/>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720230.1">
        <property type="nucleotide sequence ID" value="XM_062863074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GR95"/>
    <dbReference type="GeneID" id="87881903"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010126">
        <property type="entry name" value="Esterase_phb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050955">
        <property type="entry name" value="Plant_Biomass_Hydrol_Est"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01840">
        <property type="entry name" value="esterase_phb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43037:SF3">
        <property type="entry name" value="FERULOYL ESTERASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43037">
        <property type="entry name" value="UNNAMED PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10503">
        <property type="entry name" value="Esterase_PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0964">Secreted</keyword>
    <keyword evidence="2 9" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042315180" description="Carboxylic ester hydrolase" evidence="9">
        <location>
            <begin position="23"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3304450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="296" mass="31877" checksum="09F5D2B57F394312" modified="2024-07-24" version="1">MITLTNLVAAGAALLSGHHAFAAQLTRVDYPNNATSKPQMYIYVPDRVVSNPPLVVVIHSCQSSAQSYFQNSKIPWRTGSDRKGYITLWPSSPHSGTCWDVSSRQSLSHNGGGDSQAIANMISYAIQKYSVDAERVYLTGGSSGAMMGNVMAATYPELLKAVSIYSGVPAGCFVSASGGVDQWNNTCSGGQSRATPEQWGNVVRNMYPGYSGPRPKMQIWHGSADGTLAPANYQEIIKQWTNVFGVSQTPTSTLRNYPQANYQTDNYGENVQGIYATGVGHSVPANLTASEQWFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GRB6</accession>
    <name>A0AAJ0GRB6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">acetylornithine transaminase</fullName>
            <ecNumber evidence="5">2.6.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_568414</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 4/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.11" evidence="5"/>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720427.1">
        <property type="nucleotide sequence ID" value="XM_062870762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GRB6"/>
    <dbReference type="GeneID" id="87889591"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003992">
        <property type="term" value="F:N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000004">
        <property type="entry name" value="Acetylornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01107">
        <property type="entry name" value="ArgD_aminotrans_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004636">
        <property type="entry name" value="AcOrn/SuccOrn_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00707">
        <property type="entry name" value="argD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002325">
        <property type="entry name" value="PRK01278.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF79">
        <property type="entry name" value="ACETYLORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3304647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="464" mass="49540" checksum="DA4CDABCFFC5328C" modified="2024-07-24" version="1">MMAFRASLRAAAAAHPAVARFYSQAAAVPTSSSSFITASQIQRDAALPNPDPAEDSASAALVREHAPFMVATYSRPPPVFVKGEGSYLYDIDNRKYLDFTAGIAVNSLGHCDPGISRLIAQQAKTLMHASNLYYNPWTGALSKLLIEKTLASGGMHDATSVFICNSGSEANEAGIKFARKVGKVLDPSGAKHEIVSFGNAFHGRTMGSLSATPNPKYQAPFSPMVPGFRVGELNDVAALPSLVTPATCSVIVEPIQGEGGVTPASDDFLLALAKRCREVGALLHYDEIQCGLSRTGSFWAHSRLPREAHPDILTTAKALGNGFPIGATIVNARVTENIKIGDHGTTFGGNPLACRLGHHIVERLADPALQAEVVRKGELFRRGFEGLREGYPALVREVRGRGLILGLQLSEDPGPIVKAARERGLLVITAGTNTLRFVPSLVMSDDEIREGLAILEEAIRVTRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GS37</accession>
    <name>A0AAJ0GS37_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_188125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720847.1">
        <property type="nucleotide sequence ID" value="XM_062862410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GS37"/>
    <dbReference type="GeneID" id="87881239"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3305067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="210" mass="23368" checksum="758BF57935993187" modified="2024-07-24" version="1">MDGVEEKTGRGPDLIVVVGGFGRSEFLQSELRRNLGRNNVAFTGRDGMIAVKHGAAMHGALGNFVAMNQHEADQFNLPQVTNVPPTIHIRSRVARYSYGYSVPNGAWNAITWFVTKGQDVDFSATFTLPRNAFIFTIQNRPCAVIYRSPQSAPSNEEARQECRIKCERPDILGQLQSVPVRMRLMGSGMQFEVHGAGNEQETTFTVLYPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GSD6</accession>
    <name>A0AAJ0GSD6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_191593</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721006.1">
        <property type="nucleotide sequence ID" value="XM_062862448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GSD6"/>
    <dbReference type="GeneID" id="87881277"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF13">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="22"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="335"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="389"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="335"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="408"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="478"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3305226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="505" mass="55449" checksum="0569995DB9CE55CB" modified="2024-07-24" version="1">MSSQELSVRQINGRDNDPYYKICWDRKLGEGGFGAVYEAKTITSTSKSRTLACKVVKLSNDQNKFMYQARELKIWYKACRNAQHVAQFYDAALNRRNGEAYIYMELLAGGDTWKLSDRIQAKRDFIHPTLLSIIAYQAAYGLYEIHAKDIQHRDLKPDNLLMTRKITAEMNRALWDLEKDGRPKDNYRGDLKAVWNILHESRLVVLTDFGLARDHTATSQGRMTVVGGGFSSAWNAPEVLDGNNKQTQYADVFSFGMIIYILASFHLPQHVAERGNLPKVYSASLQTVYRWCTDDTPEKRPIAWTAMNELKSIKNAELARISKLYNNWEQSERQAAAASSSTRPAAGSSRPAGNGTACVPQAQGGGGGGRTAEHQRLLDAELARMAYEREQSEQMKQKARLKARLEGHGGGGGGGGSGSGTGGVTQAMGQLRVGDGGRHRDAGHTPYHGGGTSQPQSPRTAQGVRYVRVEGQAQGGSSQTGGGSARTGGGSSSRVIVTERTERRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GSJ5</accession>
    <name>A0AAJ0GSJ5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Non-repetitive/WGA-negative nucleoporin C-terminal-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_532002</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin Nup133 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721116.1">
        <property type="nucleotide sequence ID" value="XM_062869289.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87888118"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000972">
        <property type="term" value="P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001057">
        <property type="entry name" value="Nuclear pore complex subunit Nup133, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007187">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014908">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037624">
        <property type="entry name" value="Nup133-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405:SF11">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03177">
        <property type="entry name" value="Nucleoporin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08801">
        <property type="entry name" value="Nucleoporin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like N-terminal" evidence="10">
        <location>
            <begin position="108"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like C-terminal" evidence="9">
        <location>
            <begin position="699"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="129"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="550"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="58"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3305336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1407" mass="156939" checksum="96BDCA4D25E34ED9" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GSK0</accession>
    <name>A0AAJ0GSK0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">General negative regulator of transcription subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0T15DRAFT_397398</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721163.1">
        <property type="nucleotide sequence ID" value="XM_062864895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GSK0"/>
    <dbReference type="GeneID" id="87883724"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.1020:FF:000006">
        <property type="entry name" value="CCR4-NOT transcription complex, subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012270">
        <property type="entry name" value="CCR4-NOT_su3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007207">
        <property type="entry name" value="Not_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04065">
        <property type="entry name" value="Not3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005290">
        <property type="entry name" value="NOT_su_3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CCR4-Not complex component Not N-terminal" evidence="13">
        <location>
            <begin position="3"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="14">
        <location>
            <begin position="506"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="237"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="383"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="489"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="21"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="383"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="398"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="489"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3305383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="629" mass="69873" checksum="8470DEA5ECC6A11A" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GSU5</accession>
    <name>A0AAJ0GSU5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Complex I-B22</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NADH-ubiquinone oxidoreductase B22 subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B0T15DRAFT_532405</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Mammalian complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I LYR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721252.1">
        <property type="nucleotide sequence ID" value="XM_062869307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GSU5"/>
    <dbReference type="GeneID" id="87888136"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20263">
        <property type="entry name" value="Complex1_LYR_NDUFB9_LYRM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045292">
        <property type="entry name" value="Complex1_LYR_NDUFB9_LYRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033034">
        <property type="entry name" value="NDUFB9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12868:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12868">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B22 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="17">
        <location>
            <begin position="4"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="66"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK3305472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="98" mass="11560" checksum="7340F3C39A835A82" modified="2024-07-24" version="1">MSRQAALSLYRRSLKLALDWSVHRNLWRGQALYIRSLFEKNRDVTDPRLQRALLKETEKLLEKWKHPDPYCHPTAPGGSKYERNLPAPHFDPPPPLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GSY3</accession>
    <name>A0AAJ0GSY3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0T15DRAFT_532737</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721341.1">
        <property type="nucleotide sequence ID" value="XM_062869327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GSY3"/>
    <dbReference type="GeneID" id="87888156"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF10">
        <property type="entry name" value="SLC (SOLUTE CARRIER) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="2"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="130"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="269"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3305561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="393" mass="40762" checksum="C05328FF135AA673" modified="2024-07-24" version="1">MSADFWAGYISGAAGIIIGNPLDVVKVRLQAGAGAVPSSSSSPSSPARPAASSSSLATAPSSIHSTYIRPFLLGTAAPVLGYGALNALLFVSYNRTETFLNSLSDAGSGTPAFIVGGGSGGDGHGQGRGTNLATTWLAGAVGGLATWVVSAPTELVKCRAQLQLQVPIPTITSTTTNTTSTPSSILPGPLTTATTGGVTTARGGGSSSSSSWAIAKSVIRTEGIRGLYFGGTVTAIRDSVGYGFYFWGYELCSRWMRDLVPTGGGVMGTEAARVLLCGGLAGIITWASIFPLDVIKTKVQAQLLDRGAVLSGDGERAPLIGGDAKMGRRLGAWEVAKETYRKGGIRPFFRGLTVCSVRAFIVNAVQWAVYEWIMLELGQGRKRQDTVQLDFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GTX3</accession>
    <name>A0AAJ0GTX3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_435492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3306068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721848.1">
        <property type="nucleotide sequence ID" value="XM_062865818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GTX3"/>
    <dbReference type="GeneID" id="87884647"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3306068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="243" mass="26872" checksum="AAD92F62DD0BC16B" modified="2024-07-24" version="1">MTAPYIVGDSSPFLKRVLIPFWIIRILIMIVQIGIYALLVAGLGVFRDDIERLYAQYNTKLEYNAVLAVSCIIMAIVLLCLILDLVCIIKRARRTLSPGFFLGVNITQSIFYVVNFILTMIGARNGAIAIVISVVILLSFLGLLIYASVVYHQYRKGTLRGAYAPANNPEIHNLVAGQGFPQTAYPPQSYAQDYPAKTAYYDQQAAAQTQAAYSGMGYAAHAYGQPAPHPQQQGYEMQPRQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GU93</accession>
    <name>A0AAJ0GU93_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_567802</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3306070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721850.1">
        <property type="nucleotide sequence ID" value="XM_062870736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GU93"/>
    <dbReference type="GeneID" id="87889565"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003990">
        <property type="term" value="F:acetylcholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006581">
        <property type="term" value="P:acetylcholine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019695">
        <property type="term" value="P:choline metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042316024" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="18"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="26"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="382"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3306070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="515" mass="55156" checksum="E0C927A1B3368F27" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GUF2</accession>
    <name>A0AAJ0GUF2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1330 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_526797</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722047.1">
        <property type="nucleotide sequence ID" value="XM_062868927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GUF2"/>
    <dbReference type="GeneID" id="87887756"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40257">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40257:SF1">
        <property type="entry name" value="DUF1330 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3306267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="31283" checksum="E05CB58F896A7523" modified="2024-07-24" version="1">MVVCHLHIVSLKPGVSVASFLHNLRQNGAKPVFQARVLRWMILPRKMSTGHLLGRNIHWDVLLGLEGDGSIPASSQADIAAIWTASSGVSARALSGYGELNATLLNPLRGSVQPAELPDHSSSTSDSSENLELSPEWVQWIEALPWSVREHPVSMLNLLAFHPCKKDQYKQYGAEFSKRAGSRHGGHVKLVGRVLGSQAGADGWEEIAYVHYPSVRHFAAMAGSEDYQAVNKQYRLGALKDTFILCCQEINSDGELAGAAEPGKSKLQGSAVNIRKTNKIIVHTLIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GUX4</accession>
    <name>A0AAJ0GUX4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HotDog domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_527670</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722373.1">
        <property type="nucleotide sequence ID" value="XM_062868989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GUX4"/>
    <dbReference type="GeneID" id="87887818"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF1">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="3">
        <location>
            <begin position="84"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3306593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="182" mass="20019" checksum="9D570431F90834FB" modified="2024-07-24" version="1">MSQRQTKPQKQAAAFLQLTGEERVRKLISQFAEDAARPVSKENEPEWTQRLFPFLALHTVSSDPARPSVTFSFTVQPQHCNRLNSLHGGCTASLFDFCTSTPLALVSRPGYWSYLGVSRTLNTTYLRPAPVGTTVLIECEIVQIGQRLCALRGVMRRATDGVVLATCEHGKVNTDPAAASKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GUY5</accession>
    <name>A0AAJ0GUY5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chromatin modification-related protein EAF7-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_527828</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EAF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722417.1">
        <property type="nucleotide sequence ID" value="XM_062868994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GUY5"/>
    <dbReference type="GeneID" id="87887823"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012423">
        <property type="entry name" value="Eaf7/MRGBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13581">
        <property type="entry name" value="MRG-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13581:SF5">
        <property type="entry name" value="MRG_MORF4L-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07904">
        <property type="entry name" value="Eaf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="159"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="165"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="191"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="211"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="234"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="275"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3306637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="290" mass="31709" checksum="4E34406BAE760B9F" modified="2024-07-24" version="1">MPPKKKGGRGGAHAGATPSSATPARDEDAMEVDTPVQTPPAPAAHQLPKPITDPWTDDQVASLFKGVIRWKPAGMHKHFRILAISEHLRNHGFDPDALPHTRIPGIWAKLAEFYNLEAIDERENNMDPPDEEGQPRRYKDFELPWEDYGDLIMEKARAVPSEAPTSPPQWDPNAPPSEPKKRKRGGVEAATRSSTVEDTENDTSAASPTRKAGRGGRASKRTSSKGRKVKEESPSEEDSGEEEDTDEEDEEEDEDEEEKGTPASTKGGRGGSRGRGGRGRGRGRGRGRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GVC2</accession>
    <name>A0AAJ0GVC2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_483962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722450.1">
        <property type="nucleotide sequence ID" value="XM_062866196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GVC2"/>
    <dbReference type="GeneID" id="87885025"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37848">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37848:SF1">
        <property type="entry name" value="SUN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3306670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="394" mass="42949" checksum="40711EAD9550FA93" modified="2024-07-24" version="1">MDNTEHAESQEKARLRQHLQSQEQSPLPSPSLSRSPASGSNTVPMSEEELHPRVDSHHSPVPGPVHNPQSSTPPPYSGPTSPAQEPLPDLESQSGGSKPPPRHAGLPALDYRLYKPPLFELSQDKTTIKTSAAHLSANADALVALIRQQATIPPKPQIHIVGRRGSSHPSSGRVDFSVKLNLLPLLVPDDARQRMDYLRCVGPGEVALRGGTKPATQPDVEGDGGGLEAWAARFVADTASVKAFALERVVVNLDGNWLEGQIRALVAGMRYPGTLNVSFPVTHSRVVVQSPDRVNKFLTSVAGFFAGKRKYEVVKSVWPFATMPRGAEVGIGGRRCAVQSEEMWWKEWREPIRYAIANKRHGWVTNEDKLELLMEGLPSGAPPDVDWGPPDYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GVI4</accession>
    <name>A0AAJ0GVI4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B0T15DRAFT_510190</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722632.1">
        <property type="nucleotide sequence ID" value="XM_062867843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GVI4"/>
    <dbReference type="GeneID" id="87886672"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF11">
        <property type="entry name" value="GLYCOSYLHYDROLASE FAMILY 61-7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="16">
        <location>
            <begin position="65"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK3306852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="231" mass="24915" checksum="BF986A4029133811" modified="2024-07-24" version="1">MDEVGCYHTESVQFLGSRPPVTTVPRRIKSQLLQFVKFASLEPDDKSLLRLAAVAALAVHSVAAHYGFQQFSERGTKYPPWMYIRRNSSPDWLQNGPMTDLASSDLRCKVGGSQVSNGTEAIAMKAGDEFTFTLDTAVHHAGPVCLRSNSDSLQDRIEDEPTKIGAVVGELENVGVGVTELDADIIFAWGVVFVDALGGLLLAAGSTSRTWIILVTTTVSVTRLVIGGHVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GVL0</accession>
    <name>A0AAJ0GVL0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_528755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722753.1">
        <property type="nucleotide sequence ID" value="XM_062869061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GVL0"/>
    <dbReference type="GeneID" id="87887890"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13384">
        <property type="entry name" value="HTH_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3306973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="122" mass="13133" checksum="A6D639DA30A3F455" modified="2024-07-24" version="1">MVNLAEIGAKLTAGRQPSQELSPTARAAIIGAVAAGASQSAVARAFRIERTAVYRILQRFESSTTVKSKPQTGQPEILTCREKRYILRPHLPINDILGSSPLSDTQVAYIKENPIDEGSSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GW30</accession>
    <name>A0AAJ0GW30_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_553555</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-beta-HSD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722919.1">
        <property type="nucleotide sequence ID" value="XM_062870321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GW30"/>
    <dbReference type="GeneID" id="87889150"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050177">
        <property type="entry name" value="Lipid_A_modif_metabolic_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245">
        <property type="entry name" value="BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245:SF51">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-beta hydroxysteroid dehydrogenase/isomerase" evidence="3">
        <location>
            <begin position="12"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3307139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="351" mass="38556" checksum="0405115E93864F81" modified="2024-07-24" version="1">MPTLALTQFTVLVTGGGGFLGGHIVQQLVEDSAARAIAIVSRNPKATSNNPRVTFHAADIANDAQIKAVFDVVKPNMVIHTASPHHTEPASMQQQTNVEGTKLLLQHAKACSETHAFVYTSSDSAVVPTQEPLTEDEAELYTEAHFPDAYSRTKAVADKTVQDANCDELRTAVIRIPVIYGENDNNLIPQLLTSVRKKQHKMQIGRNNKVFEFLYIKKAAEAHILAARALLEPESASNIAGEAFFVSDGKPQPFFDFSRKCYAAAGSPVAPDEVTTIPLPAMQAMATLGEWAYKVFTAGRKMPQTRREAIDHLDRGSCWSIEKARQRLGYEPVVDQDEAIKRSMEWAIANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GW57</accession>
    <name>A0AAJ0GW57_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Inclusion body clearance protein IML2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Inclusion body clearance protein iml2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_166990</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Inclusion body (IB) resident protein that interacts strongly with lipid droplet (LD) proteins. Involved in LD-mediated IB clearing after protein folding stress, probably by enabling access to the IBs of an LD-stored soluble sterol derivative that acts as a chaperone in inclusion clearing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with lipid droplet proteins.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722977.1">
        <property type="nucleotide sequence ID" value="XM_062862176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GW57"/>
    <dbReference type="GeneID" id="87881005"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019412">
        <property type="entry name" value="IML2/TPR_39"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10300">
        <property type="entry name" value="Iml2-TPR_39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="126"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="214"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="422"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="13"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="427"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00043897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3307197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="814" mass="89419" checksum="112A461768353071" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GWL6</accession>
    <name>A0AAJ0GWL6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidoligase enzyme-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_393755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723229.1">
        <property type="nucleotide sequence ID" value="XM_062864701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GWL6"/>
    <dbReference type="GeneID" id="87883530"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022025">
        <property type="entry name" value="Amidoligase_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12224">
        <property type="entry name" value="Amidoligase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="442"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3307449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="483" mass="54036" checksum="F240BD5B43D28D9F" modified="2024-07-24" version="1" fragment="single">SMSRSRAAPPRLAPTFGVEIEIFVRLKPSFEENIRRKRLKKEHLPDYFQEWQEDLPNDSNDRLAVRQRLRVCFALKALIEQELGPDSGWRCELDLSLRQHELTAPPDPRKWWGIEMISPPMSINKHWQQEIEQVFEAVGQQFNFWTTEHTSCHVHITPGPDRSSKYTEGELANVAKGAYFWETALLDLLPVDRKKTKYARPNYELYAGLEYSKVGQDSWGPLFKKIDATADKGREIFVQRMMGIPELDEDGSRYGSHNFEPVPVEVLGTVEFRRQAGVASAETTIHRILLAITLHISARTYDFKRAQSRRSHPSSDELIAELARCERLLPAETCKPRYSFVRWLQDCQRDYRGGRRFTEKEINDREAALRPRSIRDLEPATTSAGRATSGRSAQGTGTASAGRANVGGERQGGSAPLPVRPAQSTARTSAGRTNAVGGRSGGSDLSRSAQSGTASASSGRASAAVVERISTSRSDRPSSSVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GWN2</accession>
    <name>A0AAJ0GWN2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_501953</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062867411.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87886240"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
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        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
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        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3307452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="23265" checksum="A7120A80C1C68C09" modified="2024-07-24" version="1">MGAQGLISVGVPPQPLWLLYIKIVILVLSLIVLALSGYALSISGPHPAGHPGGLNIFIAILSFIVYGGALSLELWAAQYFYRIGALLGYIFTIIFWLSAWAWSASWAAIFLSAGAYSDEMAFGGAMAGAAALGAIVWVLAIVHLAFFIRACVMDATGAGHAELGQMKAGEVPPQQYQQQYQPVQQPYPAQQQPYDAQQYQYPAQQPYGQQPYHTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723367.1">
        <property type="nucleotide sequence ID" value="XM_062866234.1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Actin-like ATPase domain"/>
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    </dbReference>
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    <feature type="region of interest" description="Disordered" evidence="2">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
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            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
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            <end position="530"/>
        </location>
    </feature>
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        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3307587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="655" mass="70998" checksum="38B1F2D98E833D85" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GXF6</accession>
    <name>A0AAJ0GXF6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_92118</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3307963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723743.1">
        <property type="nucleotide sequence ID" value="XM_062871451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GXF6"/>
    <dbReference type="GeneID" id="87890280"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3307963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="74" mass="8638" checksum="0F22460A83971849" modified="2024-07-24" version="1">MSRMLSFPFSLLSLFFFFFFFFLLFLALRVWGSWRSQSWWMELGKMVFGLLVLGLLGDTPLLGVSKDLELLAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GY29</accession>
    <name>A0AAJ0GY29_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Intradiol ring-cleavage dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_508381</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Sordariomycetes</taxon>
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            <taxon>Sordariales</taxon>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3307855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723635.1">
        <property type="nucleotide sequence ID" value="XM_062867716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GY29"/>
    <dbReference type="GeneID" id="87886545"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03457">
        <property type="entry name" value="intradiol_dioxygenase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315:SF1">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASES DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042575409" evidence="1">
        <location>
            <begin position="20"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Intradiol ring-cleavage dioxygenases" evidence="2">
        <location>
            <begin position="124"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3307855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="368" mass="39752" checksum="A1A9668B8AF56AD3" modified="2024-07-24" version="1">MALKTFLASLLLAAPLAVGHPGKEEAFAHAAQPLERKSLAHCEREFSHPEFIKKTVEIHGRELARLRRSLGIEVDEKPKIRPRDYISVSRIDHKSNKTVSKGMDLSTLFSDSGACMLMPSVDQGPLFLADDSPPDVKGEEIRKDITGGEQGIKLTLAIQVVDYKTCQTVPNAYVDIWSSNSTGIYVGVQGYPGMGDPNDASILKGTTLRGVQPTDDHGVASFDSLFPGHYEGRATHIHAIVYLGAQKQPNNTITGGRAAHVGQLYFDQSLITAANKLPPYSTNKMGITPNTADFLFMQGANGDDPIVRYALVGGDLSQGLFAWIRFGINQQASKNVNPAAFWTEKGGVMNPKGPISQLPGGGGGRREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GY61</accession>
    <name>A0AAJ0GY61_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_524190</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724116.1">
        <property type="nucleotide sequence ID" value="XM_062868746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GY61"/>
    <dbReference type="GeneID" id="87887575"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000549">
        <property type="entry name" value="ABC transporter ATP-binding protein arb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000618">
        <property type="entry name" value="ATP-binding cassette (ABC) transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF15">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="99"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="410"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3308336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="631" mass="70185" checksum="FB353C0E87A26592" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GYA6</accession>
    <name>A0AAJ0GYA6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_107138</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724178.1">
        <property type="nucleotide sequence ID" value="XM_062861440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GYA6"/>
    <dbReference type="GeneID" id="87880269"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050829">
        <property type="entry name" value="CorA_MIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47685">
        <property type="entry name" value="MAGNESIUM TRANSPORT PROTEIN CORA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47685:SF1">
        <property type="entry name" value="MAGNESIUM TRANSPORT PROTEIN CORA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="543"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="587"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="718"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="788"/>
            <end position="820"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="722"/>
            <end position="744"/>
        </location>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3308398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="842" mass="97020" checksum="A73F125E863D697C" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GYE4</accession>
    <name>A0AAJ0GYE4_9PEZI</name>
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        <recommendedName>
            <fullName evidence="2">SMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">B0T15DRAFT_524481</name>
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    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
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    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAK3308458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="62"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3308458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="119" mass="12529" checksum="D2B346930962C1E6" modified="2024-07-24" version="1">MESELPAKEQLAARATEGLPISQPEASAIAAAESDMTGRGPIKGGPAAAAQSQHDRQQNFFAVAGEVGRKPPEEMTKEDAAKVQHFEARALGHPPGKDSLAAQVQHIADKNAQTQHADK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ0GYK5_9PEZI</name>
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        <submittedName>
            <fullName evidence="6">Ribosomal protein L4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_482933</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Sordariomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723905.1">
        <property type="nucleotide sequence ID" value="XM_062866136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GYK5"/>
    <dbReference type="GeneID" id="87884965"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0005840">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="60S ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribos_uL4_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_uL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_uL4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013000">
        <property type="entry name" value="Ribosomal_uL4_euk/arc_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045240">
        <property type="entry name" value="Ribosomal_uL4_euk/arch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19431">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14374">
        <property type="entry name" value="Ribos_L4_asso_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="Ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00939">
        <property type="entry name" value="RIBOSOMAL_L1E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL4 C-terminal" evidence="5">
        <location>
            <begin position="273"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3308125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="365" mass="39137" checksum="69EF9811C53CDAE9" modified="2024-07-24" version="1">MASRPTVTVIGADGKATGATEVLPKVFSAPIRPDIVKHVHTGMAKNKRQPYAVSEKAGHQTSAESWGTGRAVARIPRVSGGGTHRAGQAAFGNMCRAGRMFAPTKVWRKWHVKINQGQKRFATASALAASAVAPLLMARGHQVATVPEVPLVVDSSAVAGEALAKTASALGLLRAVGAGPDVEKVKKSKKLRAGKGKMRGRRYRQRRGPLVVYSPEADGKELVKGFRNIPGVETCPVDALNLLQLAPGGHLGRFIIWTSAAIKQLDSVYESKKGFFLPSNVVAQADLSRLINSTEVQSVLRAPKGDARTKRGAVQKKNPLRNKQVLLRLNPYASAFQKEKLGEVKAEEGKPKPVPAAFKEQLHEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GZB1</accession>
    <name>A0AAJ0GZB1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">H/ACA ribonucleoprotein complex subunit CBF5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Centromere-binding factor 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">H/ACA ribonucleoprotein complex subunit cbf5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">H/ACA snoRNP protein CBF5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Small nucleolar RNP protein CBF5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B0T15DRAFT_392298</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs and play a central role in ribosomal RNA processing. The H/ACA snoRNP complex also mediates pseudouridylation of other types of RNAs. Catalyzes pseudouridylation at position 93 in U2 snRNA. Also catalyzes pseudouridylation of mRNAs; H/ACA-type snoRNAs probably guide pseudouridylation of mRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>uridine in 5S rRNA = pseudouridine in 5S rRNA</text>
            <dbReference type="Rhea" id="RHEA:47036"/>
            <dbReference type="Rhea" id="RHEA-COMP:11730"/>
            <dbReference type="Rhea" id="RHEA-COMP:11731"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>uridine in snRNA = pseudouridine in snRNA</text>
            <dbReference type="Rhea" id="RHEA:51124"/>
            <dbReference type="Rhea" id="RHEA-COMP:12891"/>
            <dbReference type="Rhea" id="RHEA-COMP:12892"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pseudouridine synthase TruB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724669.1">
        <property type="nucleotide sequence ID" value="XM_062864625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GZB1"/>
    <dbReference type="GeneID" id="87883454"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000495">
        <property type="term" value="P:box H/ACA sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031118">
        <property type="term" value="P:rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02572">
        <property type="entry name" value="PseudoU_synth_hDyskerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21148">
        <property type="entry name" value="PUA_Cbf5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2350.10:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012960">
        <property type="entry name" value="Dyskerin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004802">
        <property type="entry name" value="tRNA_PsdUridine_synth_B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00425">
        <property type="entry name" value="CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003280">
        <property type="entry name" value="PRK04270.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127">
        <property type="entry name" value="CENTROMERE/MICROTUBULE BINDING PROTEIN CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127:SF0">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT DKC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08068">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01136">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042550617" description="H/ACA ribonucleoprotein complex subunit CBF5" evidence="14">
        <location>
            <begin position="22"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Dyskerin-like" evidence="16">
        <location>
            <begin position="510"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="PUA" evidence="15">
        <location>
            <begin position="761"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="258"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="898"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="295"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="906"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="935"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="946"/>
            <end position="960"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00056777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00072225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00077661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00081789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK3308889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="971" mass="106316" checksum="D3B7EC144EF0950F" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GZC8</accession>
    <name>A0AAJ0GZC8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_524679</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724325.1">
        <property type="nucleotide sequence ID" value="XM_062868789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GZC8"/>
    <dbReference type="GeneID" id="87887618"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3308545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="71" mass="7832" checksum="0FC77B0721566C64" modified="2024-07-24" version="1">MLLFESLYILGLRSLMTASETASGRRWMILVVELYLICTPVGPGIIDQKGHLFLHSRLLSRSTAISPALSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GZH3</accession>
    <name>A0AAJ0GZH3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Non-specific serine/threonine protein kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_117158</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Associates with DNA double-strand breaks.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. TRA1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724510.1">
        <property type="nucleotide sequence ID" value="XM_062861574.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87880403"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05163">
        <property type="entry name" value="PIKK_TRRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046807">
        <property type="entry name" value="Tra1_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046805">
        <property type="entry name" value="Tra1_ring"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF1">
        <property type="entry name" value="TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20175">
        <property type="entry name" value="Tra1_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20206">
        <property type="entry name" value="Tra1_ring"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAT" evidence="6">
        <location>
            <begin position="2684"/>
            <end position="3239"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="5">
        <location>
            <begin position="3530"/>
            <end position="3859"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="7">
        <location>
            <begin position="3856"/>
            <end position="3888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="164"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1250"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2043"/>
            <end position="2078"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="3244"/>
            <end position="3353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1254"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="2061"/>
            <end position="2070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="3256"/>
            <end position="3271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="3309"/>
            <end position="3330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="3341"/>
            <end position="3350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3308730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3888" mass="443770" checksum="F6B08C9049AC73FD" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GZJ1</accession>
    <name>A0AAJ0GZJ1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome b5-like heme/steroid binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_573105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3309058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724838.1">
        <property type="nucleotide sequence ID" value="XM_062870919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GZJ1"/>
    <dbReference type="GeneID" id="87889748"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000003">
        <property type="entry name" value="membrane-associated progesterone receptor component 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF115">
        <property type="entry name" value="BINDING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="21"/>
            <end position="115"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3309058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="121" mass="13168" checksum="15A6C0AECF9DB0B2" modified="2024-07-24" version="1">MAGKFEPKVPVHLDSPKDDPISVEDLAKANGKDGGKCYVAIKGIVYDVTGNKAYQPGGAYHVFAGKDASRALGKTSTKPEDVSAEWQDLPDKEKSTLNDWVTFFSKRYNVVGRVEGATNFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="2">NWD NACHT-NTPase N-terminal domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="3" type="ORF">B0T15DRAFT_381748</name>
    </gene>
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        <lineage>
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            <taxon>Sordariomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3309267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725047.1">
        <property type="nucleotide sequence ID" value="XM_062864252.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87883081"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031359">
        <property type="entry name" value="NACHT_N"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042528238" description="NWD NACHT-NTPase N-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="35"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="NWD NACHT-NTPase N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
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            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF17100"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3309267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="152" mass="17630" checksum="F8F75ADDC9E344B8" modified="2024-07-24" version="1" fragment="single">KGFISQAVQVSPEASIAWAAVSLVLPLLTNPLTAAEANRDGFSYVTTRMRYYAAFESELFRLGQSRGEQVEEVTVQIVDLYEQILDFQLRSVVRFYANRFKDFLRDVVLYDGWNEKVQKIKEMEDMIFRELTQINDFASRTELEDLRKAGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ0H034_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Beta-lactamase/transpeptidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_423957</name>
    </gene>
    <organism evidence="5 6">
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        <lineage>
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            <taxon>Sordariomycetidae</taxon>
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    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
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                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725133.1">
        <property type="nucleotide sequence ID" value="XM_062865603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H034"/>
    <dbReference type="GeneID" id="87884432"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARB_00930-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051478">
        <property type="entry name" value="Beta-lactamase-like_AB/R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22935:SF97">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
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    </dbReference>
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        <location>
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        </location>
    </feature>
    <feature type="chain" id="PRO_5042589783" evidence="2">
        <location>
            <begin position="21"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-related" evidence="3">
        <location>
            <begin position="124"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-like ARB-00930-like C-terminal" evidence="4">
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            <begin position="463"/>
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        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="97"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF26335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3309353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="619" mass="66522" checksum="64507F5FD4425109" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H061</accession>
    <name>A0AAJ0H061_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">(4-O-methyl)-D-glucuronate--lignin esterase</fullName>
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        </recommendedName>
    </protein>
    <gene>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 4-O-methyl-alpha-D-glucuronosyl ester derivative + H2O = 4-O-methyl-alpha-D-glucuronate derivative + an alcohol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67452"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:171667"/>
            <dbReference type="ChEBI" id="CHEBI:171668"/>
            <dbReference type="EC" id="3.1.1.117"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:67453"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbohydrate esterase 15 (CE15) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.117" evidence="7"/>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725149.1">
        <property type="nucleotide sequence ID" value="XM_062864446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H061"/>
    <dbReference type="GeneID" id="87883275"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046274">
        <property type="term" value="P:lignin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054579">
        <property type="entry name" value="GCE-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22244">
        <property type="entry name" value="GCE_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0439">Lignin degradation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="4-O-methyl-glucuronoyl methylesterase-like" evidence="8">
        <location>
            <begin position="126"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3309369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="418" mass="44669" checksum="95AD4E6B86C856B8" modified="2024-07-24" version="1">MRTASYALIATAIGSRTAASPLDTRQAGNSTALPCAPIPSPFPTWEQLPQQSTLPDPFLPLAYTNPNDAQNVMTGKAPGRIQTREEWYACRQPEIVRMLQEYQYGYYPDRAAETVEATRSGNTLNIAVTANGKRGTFRASVSLPSGASASKPAPVVINIGGMQNQPYLSGGIAVVQFDYTSVAPDSNAKTGAFWSLYNGRDIGVLTAWAWGFHRVLDAINMTVPEIDPTRVGVTGCSRLGKAALAAGLFDARITLTMPMSSGVQGLGPYRYYTMSGQGENLENSKQGAGWWTNSKLGTFVNHAEHLPYDAHTIAAALAPRALVIDQGTGDPFTNSKATAVVVYSAAKALYDWLGVGDKIAMSVRSGGHCDMSGYTAILPYVQKIFFGTPTNKDYNNLGSYGSPVTTAFPWATAVPKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H075</accession>
    <name>A0AAJ0H075_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_515416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725196.1">
        <property type="nucleotide sequence ID" value="XM_062868192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H075"/>
    <dbReference type="GeneID" id="87887021"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3309416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="151" mass="16551" checksum="1D53519CFB76188B" modified="2024-07-24" version="1">MLQYYTLQARQKHQNPSPKKMSRYYRDPLSEHMVTHNHDLRDGSMGEPSGGETKREYEQSKPKKDAVVDESLRPSHVLGGEKNAPAPIPTETPKPRGVGNGSEMLDVVGEEREQRRQEEEGLRRSGKGSAGVGGLEGKDLKINPGGGSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H0V2</accession>
    <name>A0AAJ0H0V2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_13325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725524.1">
        <property type="nucleotide sequence ID" value="XM_062861770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H0V2"/>
    <dbReference type="GeneID" id="87880599"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3309744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="136" mass="14127" checksum="C2401BBE6993AB58" modified="2024-07-24" version="1">MMASTPIGQPPSGHHPAPRKSSQELAGSSYFDGPSVHTQPIQHYGCLPVGGLPSPAPSCRAASPPDGPNHDAMLINCSWVPISPVSPAPCEGVDGELNYALEIAPCASTLVASHSGIPGLYSWGEVNLPYEFEHAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H105</accession>
    <name>A0AAJ0H105_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">JAB1/Mov34/MPN/PAD-1 ubiquitin protease-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_516676</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M67A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725616.1">
        <property type="nucleotide sequence ID" value="XM_062868269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H105"/>
    <dbReference type="GeneID" id="87887098"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08069">
        <property type="entry name" value="MPN_RPN11_CSN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000001">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056263">
        <property type="entry name" value="RPN11_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23594">
        <property type="entry name" value="RPN11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 10" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="9">
        <location>
            <begin position="33"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="311"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3309836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="336" mass="37503" checksum="2039615C7E9B4D6B" modified="2024-07-24" version="1">MDRFRTLLGGGMSLGGAAPGTDNTNLIDNSETVHISSLALLKMLRHGRAGVPMEVMGLMLGEFVDDFTVRVVDVFAMPQSGTGVSVEAVDPVFQMKMMDMLRQTGRPESVVGWYHSHPGFGCWLSSVDINTQQSFEQLTPRAVAVVVDPIQSVKGKVVIDAFRLINPQSLMMGQEPRQTTSNLGHLNKPSIQALIHGLNRHYYSIGINYRKTALEENMLMNLHKHPWTDALQMEDFRTEGQRTKERLERLVSLAEGYEKRVKEETELTKDQLKTRYVGKLDPKKHLEDVGQQLIEDNIVAVSRQMIDKEATMAKKDAPTGANGGPNGDQMEVEEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H153</accession>
    <name>A0AAJ0H153_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">mitochondrial processing peptidase</fullName>
            <ecNumber evidence="5">3.4.24.64</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Beta-MPP</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B0T15DRAFT_387015</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalytic subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins. Preferentially, cleaves after an arginine at position P2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2.</text>
            <dbReference type="EC" id="3.4.24.64"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.64" evidence="5"/>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725701.1">
        <property type="nucleotide sequence ID" value="XM_062864358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H153"/>
    <dbReference type="GeneID" id="87883187"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000002">
        <property type="entry name" value="Mitochondrial-processing peptidase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000001">
        <property type="entry name" value="Mitochondrial-processing peptidase subunit beta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF149">
        <property type="entry name" value="GH01077P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="16">
        <location>
            <begin position="51"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="17">
        <location>
            <begin position="203"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK3309921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="475" mass="52925" checksum="25A816EBD734939F" modified="2024-07-24" version="1">MASRRLALNLAQGLRGRAGGLSVPFRRGLATPHHSPAIKTETTTLKNGLTVATQYSPYAQTSTVGMWIDAGSRAETDETNGTAHFLEHLAFKGTSKRTQHQLELEIENMGAHLNAYTSRENTVYFAKALNEDVPKCVDILQDILQNSTLEESAIERERDVILRESEEVEKQLEEVVFDHLHATAYQNQALGRTILGPRENIRDITRTELVNYIKNNYTADRMVLVGAGGIPHEQLVEMADKYFDKLPSKAPESSAYLLSKKKSDFIGSDVRIRDDTIPTANIAIAVEGVSWNDDDYFTALVTQAIVGNYDKALGNAPHQGSKLSGLVHKNDLATSFMSFSTSYSDTGLWGIYMVTDQLTRIDDLVHFALREWSRLSSNVSEAEVERAKAQLKASILLSLDGTTAVAEDIGRQIVTTGRRMSPAEIERVIDNITEKDVMDFANRKLWDKDIAISAIGSIEGLYEYMRIRADMTRNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H184</accession>
    <name>A0AAJ0H184_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome c oxidase assembly factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_516125</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Required for assembly of cytochrome c oxidase (complex IV).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 9">Component of 250-400 kDa complexes called cytochrome oxidase assembly intermediates or COA complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the COA3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725439.1">
        <property type="nucleotide sequence ID" value="XM_062868237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H184"/>
    <dbReference type="GeneID" id="87887066"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041752">
        <property type="entry name" value="Coa3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018628">
        <property type="entry name" value="Coa3_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15642:SF3">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 3 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15642">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09813">
        <property type="entry name" value="Coa3_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c oxidase assembly factor 3 mitochondrial coiled-coil" evidence="10">
        <location>
            <begin position="20"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF09813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3309659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="80" mass="8892" checksum="F4C3F4016409FA57" modified="2024-07-24" version="1">MAGIPRSTYYDSRYRQSPALIRARRPYLVKNSVVGLSIAAVAIGIYAYTIHAIGQDEFEDVKVPDAPVRSASRHDGAKKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H1G9</accession>
    <name>A0AAJ0H1G9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_14454</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725574.1">
        <property type="nucleotide sequence ID" value="XM_062861919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H1G9"/>
    <dbReference type="GeneID" id="87880748"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02958">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14345">
        <property type="entry name" value="UBA_UBXD7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01767">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006577">
        <property type="entry name" value="UAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050730">
        <property type="entry name" value="UBX_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322">
        <property type="entry name" value="FAS-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322:SF6">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13899">
        <property type="entry name" value="Thioredoxin_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00594">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="2">
        <location>
            <begin position="451"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3309794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="533" mass="59111" checksum="B839C3984C225A59" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H1Q7</accession>
    <name>A0AAJ0H1Q7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">L-arabinitol 4-dehydrogenase</fullName>
            <ecNumber evidence="10">1.1.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0T15DRAFT_517792</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-arabinitol + NAD(+) = L-xylulose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16381"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17399"/>
            <dbReference type="ChEBI" id="CHEBI:18403"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Carbohydrate degradation; L-arabinose degradation via L-arabinitol; D-xylulose 5-phosphate from L-arabinose (fungal route): step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.12" evidence="10"/>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726002.1">
        <property type="nucleotide sequence ID" value="XM_062868332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H1Q7"/>
    <dbReference type="GeneID" id="87887161"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050019">
        <property type="term" value="F:L-arabinitol 4-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019568">
        <property type="term" value="P:arabinose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF12">
        <property type="entry name" value="L-ARABINITOL 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0054">Arabinose catabolism</keyword>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="14">
        <location>
            <begin position="42"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="13">
        <location>
            <begin position="192"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3310222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="365" mass="39291" checksum="61372AA03A394956" modified="2024-07-24" version="1">MNGTIRASKPNIGVFTNPKHDLWISEATPTLESVQKGEELKEGQVTVAVRSTGICGSDVHFWKHGCIGPMIVGCDHILGHESAGEIIAVHPSVTNLKVGDRVAIEPQVICNACEPCLTGRYNGCESVDFLSTPPVPGLLRRYVNHPAVWCHKIGDMSYEDGAMLEPLSVALAGLHRAEVRLGDPVLVCGAGPIGLITLLCAKAAGACPLVITDIDEGRLKFAKEICPEVITHKVERLSAEESAKAIVKSFGGIEPAVALECTGVESSIAAAIWAVKFGGKVFVIGVGKNEIQIPFMRASVREVDLQFQYRYSNTWPRAIRLVQNGVIDLKRLVTHRFGLEDALKAFDTASDPKTGAIKVQIQSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H1T7</accession>
    <name>A0AAJ0H1T7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_19931</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725754.1">
        <property type="nucleotide sequence ID" value="XM_062862556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H1T7"/>
    <dbReference type="GeneID" id="87881385"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042540897" evidence="3">
        <location>
            <begin position="24"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="457"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="302"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="367"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3309974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="478" mass="45435" checksum="2321CB91BC343E43" modified="2024-07-24" version="1">MHLSASIFVTILLAAVAPDRTTAQRNDATNSVAGDGSTGSLRIQTVSNSAPAATPIPPEVLAAQQSSAAAVASAVAAANSAAAASGLKPPPGLQADGSPVSLQPLPALVPGDTAIAPPVVEPSTAASSVAATVETPFEAVVAPSPSATLAPPPGVDKAAPVSLAPLPNAPGVASSAAELTTASSISQAVGSFTQILSPPSASVAVETSTTAAVPESSTSYTAVLASFTPIVVDPTTAAVIFDPTSVASVIGSFIQISTSSARSSFAAPAQGFVFANGTDAASPSGVAHATGGLAPLPNNEATTSPSSGSLMPLPTTTTTTNNLTNIEGGTDSSLTNLRPLPGAPDAESESSGSLRPLPNASSQTGGTATDVEASSSSSTLLVTALLPTTTGTGAAGGSGSEASALTTLTTVGGDGVTSTLVTAVAVQTGAGAGRLASNGSASGGIAAGSGAESGVPGVRSVVVAVVGGMVGLLGVLMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H1U3</accession>
    <name>A0AAJ0H1U3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Vacuolar ATP synthase subunit E-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_31898</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase E subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726061.1">
        <property type="nucleotide sequence ID" value="XM_062864032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H1U3"/>
    <dbReference type="GeneID" id="87882861"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033178">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, catalytic domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2320.30">
        <property type="entry name" value="ATP synthase, E subunit, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00311">
        <property type="entry name" value="ATP_synth_E_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038495">
        <property type="entry name" value="ATPase_E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002842">
        <property type="entry name" value="ATPase_V1_Esu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45715">
        <property type="entry name" value="ATPASE H+-TRANSPORTING V1 SUBUNIT E1A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01991">
        <property type="entry name" value="vATP-synt_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160527">
        <property type="entry name" value="V-type ATPase subunit E-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3310281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="230" mass="25839" checksum="08CE8A1B271F6E27" modified="2024-07-24" version="1">MSQIHSLSDDQVGQELRKMTAFIKQEAAEKAREIEIKADEEFAIEKSKLVRQETDAIDSTYQKKFKQATMSQQITRSTMANKTRLRVLSARQELLDEIFAAAEKRLGEASADEERYTTVLKGLVLEGFYAMNEPELQIRARKADYEVVRKAIEKAAAEYKEKTGKEVAATIDEENDVPDGSAGGVVIVGGNGKIDINNTFEARLELLRESALPAMRKALFGENPNRKFFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H1W4</accession>
    <name>A0AAJ0H1W4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YT521-B-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_518083</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726096.1">
        <property type="nucleotide sequence ID" value="XM_062868345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H1W4"/>
    <dbReference type="GeneID" id="87887174"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990247">
        <property type="term" value="F:N6-methyladenosine-containing RNA reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21134">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057720">
        <property type="entry name" value="RRM_YTH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007275">
        <property type="entry name" value="YTH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045168">
        <property type="entry name" value="YTH_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357:SF3">
        <property type="entry name" value="YTH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357">
        <property type="entry name" value="YTH YT521-B HOMOLOGY DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25701">
        <property type="entry name" value="RRM_YTH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04146">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50882">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YTH" evidence="2">
        <location>
            <begin position="421"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="538"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="213"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="396"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3310316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="674" mass="71863" checksum="A48575DAA186240C" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H260</accession>
    <name>A0AAJ0H260_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_36706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062864177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H260"/>
    <dbReference type="GeneID" id="87883006"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3310401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="216" mass="23735" checksum="717CFE5FB5EBD578" modified="2024-07-24" version="1">MGIWWRGKERTSKARARGEREPPGPAAWLHVEVAPGTRCSVPGFLVHFRLRPGAAADSKPKSVEGQPLLRPARSHTGGRAGVRRCGVTPHQKRLFWSRTSVPVGMPHSHDACLVQMPLADPPFAQFEVPASRFFLRTALEVRGLRWLRRTLSNERTQQPRPVSRAGSGKSFFGGCRAARPSCSLTLILYFVACSGPGKRHHTSTACSLSTNATPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ0H268_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_571021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Sordariomycetidae</taxon>
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        </lineage>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726229.1">
        <property type="nucleotide sequence ID" value="XM_062870847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H268"/>
    <dbReference type="GeneID" id="87889676"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042549649" evidence="1">
        <location>
            <begin position="22"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3310449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="141" mass="15059" checksum="1392EDC87CBE9457" modified="2024-07-24" version="1">MFTSLSLIVLLGQPLFWMLEAVVDASAALGCFSKIQAFLSKAPRAEHRVIIPCHSSGSLRGVDAKTDGSDIQPAVPTGNVELQELAPAGDSQDKVDVTVRNASFSWPTDGPGLLDRINMDVRESGQKQRVLGPSLAIQLAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ0H277_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_37805</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726213.1">
        <property type="nucleotide sequence ID" value="XM_062864239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H277"/>
    <dbReference type="GeneID" id="87883068"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12383">
        <property type="entry name" value="RRM_RBM42"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
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    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050825">
        <property type="entry name" value="RBM42_RBP45_47-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034215">
        <property type="entry name" value="RBM42_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640:SF11">
        <property type="entry name" value="RNA-BINDING PROTEIN 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="224"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="152"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="308"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="163"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="180"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="323"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="355"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3310433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="368" mass="38076" checksum="6C5396D19A77AD86" modified="2024-07-24" version="1">MSYPGPPGVSKPSHPSLPPRPAVTKVGGFKPAFSPAPTAAAVGYTGPATSYPGYGPATTPASYGAPPTALPYVGNPSAPAIGAGRGGYGQGSTYNYTSQGYAQQPSYYGAAPATGYSAPPQIRNPFPAPDTATPDFDSEMAAQIAQWQSAYMPKDASDPTNKATATGGRSGTGTPALATHASTPEATTPNASGESNEKKKTVYREGGGKKWQDDSLLEWDPSHLRLFVGNLAGETTDDSLLKAFSRWKSVQKAKVIRDKRTNKSKGFGFVSFSDPEDFFQAAKEMNGKYIQSHPVVVRKAKTEIKPAVVKEDRKGKNNKSGGNKSGSGMGAGAGTNGTGAYEPHLGPMGGGGITKPGQKTKGGLKLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H2C4</accession>
    <name>A0AAJ0H2C4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_40379</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726288.1">
        <property type="nucleotide sequence ID" value="XM_062865228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H2C4"/>
    <dbReference type="GeneID" id="87884057"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF30">
        <property type="entry name" value="TR-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="2">
        <location>
            <begin position="299"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="626"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="631"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3310508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="888" mass="94180" checksum="E7F6900803B5C69D" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H2J7</accession>
    <name>A0AAJ0H2J7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Muts domain V-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_42483</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726352.1">
        <property type="nucleotide sequence ID" value="XM_062865624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H2J7"/>
    <dbReference type="GeneID" id="87884453"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043504">
        <property type="term" value="P:mitochondrial DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000042">
        <property type="entry name" value="DNA mismatch repair protein Msh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.10:FF:000010">
        <property type="entry name" value="DNA mismatch repair protein Msh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF34">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="9">
        <location>
            <begin position="940"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="593"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="682"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="823"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="639"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="706"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="825"/>
            <end position="834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3310572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1082" mass="119019" checksum="04133FF5C5A6799E" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H2W1</accession>
    <name>A0AAJ0H2W1_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_39883</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726275.1">
        <property type="nucleotide sequence ID" value="XM_062864973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H2W1"/>
    <dbReference type="GeneID" id="87883802"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046591">
        <property type="entry name" value="DUF6649"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20354">
        <property type="entry name" value="DUF6649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3310495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="246" mass="27479" checksum="3B635F8CDF0C12E1" modified="2024-07-24" version="1">MDTLGIDPSYAAYQHQHHNHTHGHFATQQLPSITARKRKADAPPENNERLSKRMSLLNLEQSGQKLLVPVENIRSHFPDHINKSHENKQRPGDVDDSRMQLDDTKYKVYINNLDDELASDNESDGESGMVFLPDIEKYLRATRIPTRVLDPRPDPAAELAGKELVLYSEPSSISVPIEQDSVRRAILEARARAREKQRAEREREPAACQAPVPGPMTTLSAPSARMLVGAVSGLGHVEDPDAMELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H323</accession>
    <name>A0AAJ0H323_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SH3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_51248</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726607.1">
        <property type="nucleotide sequence ID" value="XM_062867983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H323"/>
    <dbReference type="GeneID" id="87886812"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050670">
        <property type="entry name" value="STAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929:SF7">
        <property type="entry name" value="LAS SEVENTEEN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="108"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="51"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="197"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3310827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="260" mass="27837" checksum="E017FA3F6C97129D" modified="2024-07-24" version="1">MVSEDRQRVIETNRSLRLIKNELESLLEKGIITDTAFDSITALLPAETPLSGAAATRTPAPATPASTTSLPSQSPAPAPQPPSYAQSTASPPSLPARNPPPATVPDKPVLVHARALYTYHASDARDCSFERDDRIAVHEYMNADWWMGRNLRTGQEGIFPRNYVVVDSSVDEKQQQHPAPSPAAGYYPVAPVPVSGYHAPPPAAPVGQWQGQDQQQQQQQQDGGNSKLGEHGKKFGKKLGNAAIFGAGATIGSNIVNSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H3A2</accession>
    <name>A0AAJ0H3A2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pyruvate dehydrogenase E1 component subunit beta</fullName>
            <ecNumber evidence="10">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0T15DRAFT_59099</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
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            <location evidence="2">Mitochondrion</location>
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    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="10"/>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name type="scientific">Chaetomium strumarium</name>
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            <taxon>Eukaryota</taxon>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
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                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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            <strain evidence="2">CBS 333.67</strain>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3310785.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1650" mass="174688" checksum="6A20BA62CC6D1BA2" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H3J8</accession>
    <name>A0AAJ0H3J8_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726684.1">
        <property type="nucleotide sequence ID" value="XM_062868455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H3J8"/>
    <dbReference type="GeneID" id="87887284"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3310904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="254" mass="27586" checksum="11CA921674C1DBF4" modified="2024-07-24" version="1">MLCGIHSHSGHHHHRFLRSSRSHKSNKKMLPQSHQPSRAGMPARPSLESSPRPSTASSRSDGSIDWDPLRLHPFSLAPGPAPPLPDASVDSTSRPYQPQELRQSRSSHNPRHQSPPSRHYASSSKTVIYGGFDFGFNNNNNNSLSQAMPSMTDESTTGGASRRAPSPTPSDASSECSLCPSDDIDEGISLGLGLAPPPAPRPRPRPRPDRGDGSSSSGLDDDAEDFLRRGRWKRRGIVFANTMPLAGEDETFEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ0LY05_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_578082</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717614.1">
        <property type="nucleotide sequence ID" value="XM_062871084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LY05"/>
    <dbReference type="GeneID" id="87889913"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042492363" evidence="2">
        <location>
            <begin position="18"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3301834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="323" mass="36764" checksum="D30225B4FD441CBF" modified="2024-07-24" version="1">MLSPLLLLPLLFPPTHAGGINWDVYEYGVAPSFHWSRPFPDDGTEPGGFHVHCRASQTFRAKLFKLKDLPEPWPTGLAPWQGEIDGWLGLSSGRREYMGSWDGVDHKGEDREIVVMDWAEVPEGVRGWIAEQRQEEQQGGDEGNGRKENEKRWWFGVFEKKPRKEEGEKVGGTVGAAGSSASASVSEQGVEAEAQEKREIKDGDRIVVFPAGAAYEILPLWVAKGSGCERDFNNLAKYKPQAIDHAVVAWVVDHTKPHRDLGKRDMTFTVEAMSVTESEEGRHARLMWEKLHRTIKRNERRQQREERLKARREMEEGRVRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LYU9</accession>
    <name>A0AAJ0LYU9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_543880</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718542.1">
        <property type="nucleotide sequence ID" value="XM_062870025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LYU9"/>
    <dbReference type="GeneID" id="87888854"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000001">
        <property type="entry name" value="Fungal specific transcription factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004507">
        <property type="entry name" value="UbiX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374">
        <property type="entry name" value="FLAVIN PRENYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374:SF1">
        <property type="entry name" value="FLAVIN PRENYLTRANSFERASE PAD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="129"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="160"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3302762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="836" mass="92114" checksum="D0F5906475C5E775" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LYY0</accession>
    <name>A0AAJ0LYY0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_487799</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718589.1">
        <property type="nucleotide sequence ID" value="XM_062866460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LYY0"/>
    <dbReference type="GeneID" id="87885289"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="2">
        <location>
            <begin position="151"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3302809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="271" mass="31585" checksum="B43D11EFEC188B7D" modified="2024-07-24" version="1">MAPPLFLHGHRESGCFAVLADRKYYRRGNLFIKRTLRKHEWTELSSDTVAEPSAALPQRFRTDVAVQQYLRERTNIPLPAFASTFEDDGAMYLLPEEDRRVIEKELQQHMGTLKSLRSDTLGVPGEQLRVAPQRVCDMSWIYYTCWRPRSNVKGDFVFCHNDLGQHNVLVDPKTLKITAIIDWEFGGFWPEWFERPFWMRPDDTERCREWLTANFEAVEQQHLPTLQDKLDSMPWTPKVLDDELPSQKVAEPTKQTKDEPEVAIASPIHTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZQ2</accession>
    <name>A0AAJ0LZQ2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endoplasmic reticulum chaperone BiP</fullName>
            <ecNumber evidence="4">3.6.4.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Immunoglobulin heavy chain-binding protein homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0T15DRAFT_486919</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER. Is required for secretory polypeptide translocation. May physically associate with SEC63 protein in the endoplasmic reticulum and this interaction may be regulated by ATP hydrolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.10" evidence="4"/>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719323.1">
        <property type="nucleotide sequence ID" value="XM_062866393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZQ2"/>
    <dbReference type="GeneID" id="87885222"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006986">
        <property type="term" value="P:response to unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10241">
        <property type="entry name" value="ASKHA_NBD_HSP70_BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000009">
        <property type="entry name" value="DnaK-type molecular chaperone BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000153">
        <property type="entry name" value="Endoplasmic reticulum chaperone BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042050">
        <property type="entry name" value="BIP_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0346">Stress response</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042507932" description="Endoplasmic reticulum chaperone BiP" evidence="15">
        <location>
            <begin position="33"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="644"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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</entry>
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                <person name="Brannstrom I.O."/>
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
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                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
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                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
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                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
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                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
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    </reference>
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
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                <person name="Chen C."/>
                <person name="Yanf M."/>
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                <person name="Ng V."/>
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                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
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                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
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        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <person name="Kuo A."/>
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                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
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<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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                <person name="Kuo A."/>
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                <person name="Riley R."/>
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            <strain evidence="4">CBS 333.67</strain>
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    <reference evidence="4" key="2">
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                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
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                <person name="Ng V."/>
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                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
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                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
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                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Glycosidases"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154:SF13">
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        <property type="match status" value="1"/>
    </dbReference>
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            <end position="21"/>
        </location>
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            <begin position="22"/>
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        </location>
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            <begin position="191"/>
            <end position="412"/>
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            <end position="152"/>
        </location>
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        </location>
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        <source>
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        <source>
            <dbReference type="Pfam" id="PF11790"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3304547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
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</entry>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        </location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3304624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ0M1D2_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2 3">
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
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                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721181.1">
        <property type="nucleotide sequence ID" value="XM_062869298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M1D2"/>
    <dbReference type="GeneID" id="87888127"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3305401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="266" mass="29141" checksum="60EAB1AF03F913E6" modified="2024-07-24" version="1">MTRKQTATNLIWPDDDDAQDDLTHLDPIPSYEESLVAPRPPGDGSSPALHILGATWGGVTVTPDIQALAGNNSDTLTLDMRNIFRHLTPDPAPGKTKVLTVMYRFNNSNNNSAKGGSDEEDEGLRLLLAPEGESPSRVTLTRHATAEQLRRSVGRNSMHVKLAAAAGAGAGPGARPLGSQRGQVEILAVLYGPRRIDDPAVLRELALFFEGRRGQIRMTNRFFGGDPWPYKQKSWSVYFRFLGSPRVQVVTGWEDGALEVPWTRDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M1Q4</accession>
    <name>A0AAJ0M1Q4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histone H1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_209011</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Could act as an H1-type linker histone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the histone H1/H5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721545.1">
        <property type="nucleotide sequence ID" value="XM_062862648.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87881477"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Histone H1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="H1/H5"/>
    </dbReference>
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        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00538">
        <property type="entry name" value="Linker_histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00624">
        <property type="entry name" value="HISTONEH5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00526">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51504">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="H15" evidence="8">
        <location>
            <begin position="22"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="82"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="170"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00055135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3305765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="232" mass="24106" checksum="D9E5B5820BB8B6C4" modified="2024-07-24" version="1">MPPKKTEAKSEGAAAATTKTATHPPYQDMITDAIISLKDRNGSSRQSLKKYVRANNNLGNVGEKMFDNLFNRALKAGVEKGIFEQPKGPSGGTKLAKKAATPAAPKKAAPKKETAAKKEAAPKKEAKEKKPAAKKPAAKKAAPKKETAGKKEAAPKKADVQKKAKKAAAPKKAPAAPAVVDKPTVLTKTKSGRVAKTAAKPAAPKKAAPKKAAAPKKEKTPKKAEKAEAASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M222</accession>
    <name>A0AAJ0M222_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_503053</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3306048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721828.1">
        <property type="nucleotide sequence ID" value="XM_062867458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M222"/>
    <dbReference type="GeneID" id="87886287"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="529"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="310"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="330"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3306048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="580" mass="62704" checksum="878EC7BCE5D7C22A" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M353</accession>
    <name>A0AAJ0M353_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_173954</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723105.1">
        <property type="nucleotide sequence ID" value="XM_062862224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M353"/>
    <dbReference type="GeneID" id="87881053"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
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                <person name="Brannstrom I.O."/>
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
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                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
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                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
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                <person name="Ohm R.A."/>
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                <person name="Ament-Velasquez S.L."/>
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                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="1">CBS 333.67</strain>
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        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <person name="Powell A.J."/>
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                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
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        </source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
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        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAK3307743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062865359.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87884188"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS drug efflux transporter, putative"/>
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    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
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        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF12">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="236"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="282"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="308"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    <feature type="transmembrane region" description="Helical" evidence="8">
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        <location>
            <begin position="534"/>
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    </feature>
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        <location>
            <begin position="63"/>
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        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3307743.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="566" mass="60342" checksum="B237B9B780186DFD" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">B0T15DRAFT_522962</name>
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        <name type="scientific">Chaetomium strumarium</name>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723689.1">
        <property type="nucleotide sequence ID" value="XM_062868659.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87887488"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="539"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
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        <location>
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            <end position="33"/>
        </location>
    </feature>
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        <location>
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            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="245"/>
        </location>
    </feature>
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        <location>
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            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
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            <end position="391"/>
        </location>
    </feature>
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            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
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            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
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            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="771"/>
            <end position="795"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3307909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="795" mass="86830" checksum="D6B8A28E219D4718" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M4V6</accession>
    <name>A0AAJ0M4V6_9PEZI</name>
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        <recommendedName>
            <fullName evidence="2">glutamate-5-semialdehyde dehydrogenase</fullName>
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        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Glutamate-5-semialdehyde dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Glutamyl-gamma-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0T15DRAFT_130609</name>
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    <organism evidence="13 14">
        <name type="scientific">Chaetomium strumarium</name>
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        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the NADPH dependent reduction of L-gamma-glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-glutamate 5-semialdehyde + phosphate + NADP(+) = L-glutamyl 5-phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19541"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the gamma-glutamyl phosphate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.41" evidence="2"/>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3309123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724903.1">
        <property type="nucleotide sequence ID" value="XM_062861745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M4V6"/>
    <dbReference type="GeneID" id="87880574"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004350">
        <property type="term" value="F:glutamate-5-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07079">
        <property type="entry name" value="ALDH_F18-19_ProA-GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000006">
        <property type="entry name" value="Gamma-glutamyl phosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00412">
        <property type="entry name" value="ProA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020593">
        <property type="entry name" value="G-glutamylP_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012134">
        <property type="entry name" value="Glu-5-SA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000965">
        <property type="entry name" value="GPR_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001221">
        <property type="entry name" value="PRK00197.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00407">
        <property type="entry name" value="proA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11063:SF8">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11063">
        <property type="entry name" value="GLUTAMATE SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000151">
        <property type="entry name" value="GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01223">
        <property type="entry name" value="PROA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="12">
        <location>
            <begin position="10"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00075718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3309123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="448" mass="47678" checksum="F83FAE2055FDEF4F" modified="2024-07-24" version="1">MSLTNASPVDAARAAKSASHVLATLSTDARNEALTAIHAGLAAARDDILAANARDLELAQQAAADGKLSSSLVARLDLGKKGKWDDMLKGILDVRDLEDPVGRVTLRTRLDDGLELERVTCPIGVLLIIFEARPEVIANIAALAIKSGNAAILKGGKESTESFVAISRVISAALEQTQVPNGAIQLVTTRDVIPELLALDEHIDLVIPRGSNDLVRYIKNNTRIPVLGHADGLCAIYLEQTADPTMAAEVIVDAKTSYPAACNALETLLVQDSALMTVLPTVAEALAAKGVELRCDAASRDALQDTIIPKLTIADATDADYRTEFLSLTLAVKTVSSLAEAVEHINTHGSHHTDCILTSSPEQAEQFMAAVDSAGVYWNASTRFADGMRYGFGTEVGISTNKIHSRGPVGLDGLMIYKYKLRGKGQVTAAYGAGEGKRKFLHQRLPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M4X9</accession>
    <name>A0AAJ0M4X9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_133830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3309212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724992.1">
        <property type="nucleotide sequence ID" value="XM_062861783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M4X9"/>
    <dbReference type="GeneID" id="87880612"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3309212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="335" mass="36860" checksum="6645168FD4C9508B" modified="2024-07-24" version="1">MFSAASSHTKGHKQSSGHGKRQSTSKPSKPSKTKDTARPVDHGTIPYSFLFVVNEFQVDYEPIHPRDRPLTDPWLNIMPPEEAAAYRDEAIGTVFRYLDGVVSPAPGYVWYRPQMGAKGCIVRINQASAITGYPAIYSETTVFSCSPLLPMIVTHDDASVGRTFMRRGCECDRRCDGYAAWSLLHFTGGDSQEGISSVNSYASGAPCVTGRDPSWIPSLVPSIYRNTKSSAPPSRGLAGELGIILALMGFHGKKTQASDVFVNQTWHRNRWNGPSRASNYLPKEGDSPRGLFVQVCHDNLVDGQPDDEEHNLPQELCEQVLSYLEYGYGSILVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M4Y2</accession>
    <name>A0AAJ0M4Y2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_126406</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3309004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724784.1">
        <property type="nucleotide sequence ID" value="XM_062861689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M4Y2"/>
    <dbReference type="GeneID" id="87880518"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF3">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="10"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="45"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="77"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3309004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="495" mass="55724" checksum="DE15AABD126A7C6E" modified="2024-07-24" version="1">MSEQGIQSVLRCGRCNKPFDKQSTLKRHGYYCRSRQDEPATRTRSCNSCARRKARCDNKRPACSACLTKGIECHYPAKTPRGTGRGPQSVRQRTERDVPTAHPPETVSAPISDAISHHSLFNDAPVISDLSVSAADSGDVYLPWDGQDIAFADFILPQMNDAALQFFPALESTTPLSTPLQETIQPHRVSIPAPPLNFSGSLVQRPRTGLAMQRMAKLVLQQLKSYPLMMLRHNTLPPFIHPRLLSDVEKSDMEPLHNCMSLLHMLGSQVPGSRKLVWRNVRMECERFRKEYLGWNKRELLAAMQALAIYLIIRLDEDQTEHNDLDLDLLFVATVAEIAVQYNSVATMVSGIDSELSWDDWIWEESMRRLCVIYQVVDLLVFWRPAALCHLREKNLLIAPLPARKHLWEAGDEATWKAESKREERQHPGVSFALTADGELVKVDERQAVYTNGPVSLPKPSDASTPPWTTANWDEWCSEMDGLGSLVMLAASLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M518</accession>
    <name>A0AAJ0M518_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">INO80 complex, subunit Ies4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_130013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3309109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724889.1">
        <property type="nucleotide sequence ID" value="XM_062861741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M518"/>
    <dbReference type="GeneID" id="87880570"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013175">
        <property type="entry name" value="INO80_su_Ies4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28061">
        <property type="entry name" value="INO EIGHTY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28061:SF1">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08193">
        <property type="entry name" value="INO80_Ies4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3309109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="267" mass="27355" checksum="BD1882FEF39BC128" modified="2024-07-24" version="1">MAPSSKNAAASKDRRKSNNSTPITSISSAGSTKPSRIVKLKVSSVKLRAIVDPNHVKDETSAKPSPAAAPNSNTESASESTLNSPPAGTPAAQSAIMGPPAEGPKKKGVKRSAGAAANGNGEPKLRGRPGPKKKQRLDDGTIEGGRGSVAPHKLGPKANQGAINAGLRALDRSGKPCRKWTRGGFKLKSFTGVVWEIPRWTAPPKPQPESSAEGSGPASVDSSNKENKEDASQLKSEASNNGGDIDMQSAASFAADNSPAPLALTAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M567</accession>
    <name>A0AAJ0M567_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ca3427-like PBP 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_392634</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial solute-binding protein SsuA/TauA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3309245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725025.1">
        <property type="nucleotide sequence ID" value="XM_062864647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M567"/>
    <dbReference type="GeneID" id="87883476"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd13637">
        <property type="entry name" value="PBP2_Ca3427_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054364">
        <property type="entry name" value="Ca3427-like_PBP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30024">
        <property type="entry name" value="ALIPHATIC SULFONATES-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30024:SF47">
        <property type="entry name" value="TAURINE-BINDING PERIPLASMIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22384">
        <property type="entry name" value="PBP2_Ca3427_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ca3427-like PBP 2" evidence="4">
        <location>
            <begin position="94"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3309245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="312" mass="34216" checksum="2914ECE4D60C806B" modified="2024-07-24" version="1">MTSTTQPRALRVGFVPEHFSTPIHFAKKHYGLDAELIPFPSGTGHMITALCGGEIDVGIGLTEGWVAALGRSQVDRQDGGFRLVGTYVESPLCWAVSTGTDRPEIRSVDSLQGAKIGVSRIGSGSYVMGYVLADQRGWLIPSAGAGTAGEQALPFSEFVVLDTFERLRGAVNSGAADFFMWEHFTSKRYYDRGEIRRVGEIYTPWSSWKIVASTGLVDDTSNDTRLDDLLDKLNRGIQHFNENKEEAVQYISTELDYSAEDAQEWLKTVRFPERTQGVDEQVISGCVDALCKAGLLPVGKGVNAAEMIARQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M5C0</accession>
    <name>A0AAJ0M5C0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein L31e-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_386892</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725458.1">
        <property type="nucleotide sequence ID" value="XM_062864352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M5C0"/>
    <dbReference type="GeneID" id="87883181"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00463">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.440.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000054">
        <property type="entry name" value="Ribosomal_eL31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020052">
        <property type="entry name" value="Ribosomal_eL31_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023621">
        <property type="entry name" value="Ribosomal_eL31_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956:SF0">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01198">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01380">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54575">
        <property type="entry name" value="Ribosomal protein L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01144">
        <property type="entry name" value="RIBOSOMAL_L31E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3309678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="122" mass="13896" checksum="DF6E0EE17E50C4D1" modified="2024-07-24" version="1">MSSKKPSGKATRSAIADVVAREYTIHMHKRLHGVTFKKRAPRAIKEIKAFATKAMGTTDVRLDPQLNKKVWEQGVKGVPYRLRIRISRRRNDEEGAKEKLYSYVQAVNVKNPKGLHTVVVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M5K0</accession>
    <name>A0AAJ0M5K0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rhodopsin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_516237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725475.1">
        <property type="nucleotide sequence ID" value="XM_062868244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M5K0"/>
    <dbReference type="GeneID" id="87887073"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28139">
        <property type="entry name" value="UPF0768 PROTEIN YBL029C-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28139:SF1">
        <property type="entry name" value="UPF0768 PROTEIN YBL029C-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3309695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="116" mass="12967" checksum="E220B485585891BC" modified="2024-07-24" version="1">MCIPIIFTCGEQTFRKDVPGYEGLVCQCYNCGNYSASVIKSHPWFTFCFIPVIPLSMKGYEDIKCRICNFEQPLEQRGDVQALRGQGGPGVHMQPPGPRPGGVPGMPKPNEPMRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M644</accession>
    <name>A0AAJ0M644_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_29023</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725997.1">
        <property type="nucleotide sequence ID" value="XM_062863698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M644"/>
    <dbReference type="GeneID" id="87882527"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000036">
        <property type="entry name" value="Oxidoreductase, 2OG-Fe(II) oxygenase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209:SF812">
        <property type="entry name" value="2OG-FE(II) OXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209">
        <property type="entry name" value="OXIDOREDUCTASE, 2OG-FE II OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="6">
        <location>
            <begin position="174"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3310217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="403" mass="43780" checksum="DA400E097103A82B" modified="2024-07-24" version="1">MSFTSIPILDLALAGDPATKQGFLSELRHALMEVGFLYLRNVGISDEFFKQVIEEGKAFFDIPPEEKLKIEMKNAPSFLGYSRLSAEVTAGEIDHREQIDLSTEHPLPGPDAPRYYNLLAPNQWPSPETLPNFRPVFTEYMKRMGEISMYFTSLIAEAIELPSDAFNKYFDSDQQHKLKIVKYPDVGTLGAEGKGGNQGVGPHKDSMLSSYLLQASHHRGLQVQNMRGEWIDCPPIDGTLVVAIGQGLEALTQGVCVSTTHRVLSPPAGAGARFSIPFFQGVSGDADFDDLENVGVGKVPEHVRGQRRAVLERNGGVRLDDVEFTFRKGGAARTLGEATLRNRVKSHPDVGERWYPDILASVREEQARLKESGGTGKGAAAAAAAAAAAAEIPVAGAKPVEAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M652</accession>
    <name>A0AAJ0M652_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_40573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726298.1">
        <property type="nucleotide sequence ID" value="XM_062865303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M652"/>
    <dbReference type="GeneID" id="87884132"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042532724" evidence="1">
        <location>
            <begin position="18"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3310518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="335" mass="34521" checksum="6A305C74A43B8031" modified="2024-07-24" version="1">MKVHTLGLVCIIGSALAVPVLNGQTQHSQQVHAQQAEQEPPAPIVSDVPVTCPFEEEDGDEEMDPEKEMDPERVMMVAGHGQMRRALNILSAHVDTNAFQDVVNQVQEQVQQIEQLIHEKGSDSDALMQALVDPMSRLNQTLAVGVSRLALPIPDLGGIVGGVGGSASQPAPPLLVLVELLRAVSNLLENLLSGNPIADLLGDVLGGIGGAVGDVLGDDYAAQIEALIDSILGSIASLLPGAGGAVPTPVPLIPVPLPSVPVPSVPVPSIPVPEVPFPEVSVPSVPVPEHSVPPVPEPTVPVPVPVPEIPAPVPDISAPGVPVPSVPPVPTDIFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M6B0</accession>
    <name>A0AAJ0M6B0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA replication licensing factor MCM4</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">DNA replication licensing factor mcm4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B0T15DRAFT_564572</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726463.1">
        <property type="nucleotide sequence ID" value="XM_062870645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M6B0"/>
    <dbReference type="GeneID" id="87889474"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097373">
        <property type="term" value="C:MCM core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17755">
        <property type="entry name" value="MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000011">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000217">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008047">
        <property type="entry name" value="MCM_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF66">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21128">
        <property type="entry name" value="WHD_MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01660">
        <property type="entry name" value="MCMPROTEIN4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="17">
        <location>
            <begin position="598"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="327"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="70"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="119"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="334"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00073498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00074938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK3310683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1018" mass="112035" checksum="FF21D4C7883A8EED" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M6D7</accession>
    <name>A0AAJ0M6D7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_518907</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726374.1">
        <property type="nucleotide sequence ID" value="XM_062868399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M6D7"/>
    <dbReference type="GeneID" id="87887228"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052053">
        <property type="entry name" value="IM_YidH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187:SF2">
        <property type="entry name" value="DUF202 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187">
        <property type="entry name" value="FGR18P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="8">
        <location>
            <begin position="170"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3310594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="287" mass="31296" checksum="7BBE08D40AF60CB2" modified="2024-07-24" version="1">MSENAAAPAPRSPNTTLQLQRRKSSRDRIRDILEGARERAESLDADPASPRLQPLLGDPNRRASGPSGSASPPALDALRQGVVTAQPGRQRTLDYQSTAEISPAARRRSTRDGKSSAQPQGPPPPPGADGAAEEDDSRGQPRGQREEPCWKRALRYFKSIELENKGSVARDHLALERTFLAWLRTSLAFASIGIAITQLFRLNTSLAEDTKQAERLRHLGKPLGTAFLAVSILILLLGYNRYLQGQHWVIKGKFPASRGTIMLVSLIAFTVTLASLVVILAVQNNPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M6P1</accession>
    <name>A0AAJ0M6P1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Aspartic peptidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0T15DRAFT_53090</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726645.1">
        <property type="nucleotide sequence ID" value="XM_062869201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M6P1"/>
    <dbReference type="GeneID" id="87888030"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05474">
        <property type="entry name" value="SAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033876">
        <property type="entry name" value="SAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF65">
        <property type="entry name" value="ASPARTIC-TYPE ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042545977" evidence="10">
        <location>
            <begin position="18"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="494"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="11">
        <location>
            <begin position="59"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="453"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3310865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="515" mass="54017" checksum="10D087037227B59A" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M6P7</accession>
    <name>A0AAJ0M6P7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD dependent epimerase/dehydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_61355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726881.1">
        <property type="nucleotide sequence ID" value="XM_062871128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M6P7"/>
    <dbReference type="GeneID" id="87889957"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08946">
        <property type="entry name" value="SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43000">
        <property type="entry name" value="DTDP-D-GLUCOSE 4,6-DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="2">
        <location>
            <begin position="6"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3311101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="366" mass="39923" checksum="BC65B9BD85EEE6B4" modified="2024-07-24" version="1">MSKPTVLVTGSAGHLGKALMLALPDLGYTPIGIDINASPTTTFVGSITDTAFLSQIFSTHSISHVIHAATLHKPHVGSHSKNDFIQTNIAGTLALLEAASSSSSSSSSSSFSDENVGKTKPKTVESFIYISTTSTFGSALSPSRGQPAAWIDESVVPVPKNIYGVTKTAAEDVCRLVHRETGLPVIVLRTSRFFPEEDDDEERRSAMEGENLKVLELAYRRVDIADVVSACVCAMERAARHTNTKGQVRWGKYIISAPTPFGRDAETLRGLDEDAAEVFKKAVLGCVGVFERKGWRFLDRLDRVYDSTRAVEELGWKPEYTFEKAVEKVGKGEEWRSPLTFKVGKLGYHAVPTGVYTTREEATMTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M6Q8</accession>
    <name>A0AAJ0M6Q8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">40S ribosomal protein S13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_520528</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062868508.1"/>
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    <dbReference type="AlphaFoldDB" id="A0AAJ0M6Q8"/>
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    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="40S ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S15/NS1, RNA-binding"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_uS15_arc_euk"/>
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    </dbReference>
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        <property type="entry name" value="PRK08561.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885:SF6">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US15"/>
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        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
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        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00008434"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM01386"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3311131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M6S7</accession>
    <name>A0AAJ0M6S7_9PEZI</name>
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        <submittedName>
            <fullName evidence="3">MM3350-like domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">B0T15DRAFT_548078</name>
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        <name type="scientific">Chaetomium strumarium</name>
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            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
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            <taxon>Chaetomium</taxon>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726794.1">
        <property type="nucleotide sequence ID" value="XM_062870187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M6S7"/>
    <dbReference type="GeneID" id="87889016"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.30">
        <property type="entry name" value="MM3350-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Plasmid_pRiA4b_Orf3-like"/>
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        <property type="entry name" value="PRiA4_ORF3"/>
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    </dbReference>
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        <property type="entry name" value="MM3350-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="3"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF07929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3311014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="91" mass="10326" checksum="EB6056CDBA285252" modified="2024-07-24" version="1" fragment="single">YAGKQVIYMYDFGDNWEHNLSVEGRADPTDRFVCLSGTGHAVAEDVGSVDGWRELKDAYCTSHPTKEQRERRQWYERTASNGDPEGLAGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M753</accession>
    <name>A0AAJ0M753_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_388745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Sordariomycetes</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727316.1">
        <property type="nucleotide sequence ID" value="XM_062864456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M753"/>
    <dbReference type="GeneID" id="87883285"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="521"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3311536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="599" mass="67831" checksum="FCCD1A0CCC04F6BD" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GKM9</accession>
    <name>A0AAJ0GKM9_9PEZI</name>
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        <submittedName>
            <fullName evidence="7">ZIP zinc transporter-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_321218</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717468.1">
        <property type="nucleotide sequence ID" value="XM_062864056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GKM9"/>
    <dbReference type="GeneID" id="87882885"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF55">
        <property type="entry name" value="MEMBRANE ZINC ION TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G00470)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="349"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3301688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="551" mass="57993" checksum="7DD88998EF051905" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ0GKZ6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomium</taxon>
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    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717648.1">
        <property type="nucleotide sequence ID" value="XM_062864113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GKZ6"/>
    <dbReference type="GeneID" id="87882942"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3301868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="207" mass="23079" checksum="80A444847870F23C" modified="2024-07-24" version="1">MKVSAEPFATTASSLGSYLRVFDNLIARSDVHVLQVEEPDPRGAAAIRAITYNDILIAAKILRSNPTLTLDEAAEQLWARLGTTCSARQPRLTMRVSVRAMFMIDCTGPVDGWLPNERFDDLASRVFPRALAISTAAKEAMNDRKSMKAWKLKARFRLHCRGTDNLARHLLLDLSHPDGADPVYRSLYWLSQGPTGPWEARRSLQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GLB6</accession>
    <name>A0AAJ0GLB6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 19">ATP-dependent DNA helicase II subunit 2</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">B0T15DRAFT_541808</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. KU70, of the KU70/KU80 heterodimer, binds to the stem loop of TLC1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 19">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 19">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the ku80 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4 19"/>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717828.1">
        <property type="nucleotide sequence ID" value="XM_062869889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GLB6"/>
    <dbReference type="GeneID" id="87888718"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043564">
        <property type="term" value="C:Ku70:Ku80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00873">
        <property type="entry name" value="KU80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.290.10:FF:000008">
        <property type="entry name" value="ATP-dependent DNA helicase II subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000073">
        <property type="entry name" value="ATP-dependent DNA helicase II subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1600.10:FF:000002">
        <property type="entry name" value="X-ray repair cross-complementing protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.240">
        <property type="entry name" value="Ku, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="DNA_bd_Ku70/Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024193">
        <property type="entry name" value="Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036494">
        <property type="entry name" value="Ku_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005161">
        <property type="entry name" value="Ku_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014893">
        <property type="entry name" value="Ku_PK_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604">
        <property type="entry name" value="KU AUTOANTIGEN DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604:SF4">
        <property type="entry name" value="X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03731">
        <property type="entry name" value="Ku_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08785">
        <property type="entry name" value="Ku_PK_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016570">
        <property type="entry name" value="Ku80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101420">
        <property type="entry name" value="C-terminal domain of Ku80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 19" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14 19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="15 19" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13 19" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 19" id="KW-0347">Helicase</keyword>
    <keyword evidence="9 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16 19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="Ku" evidence="20">
        <location>
            <begin position="311"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRNR" id="PIRNR016570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAK3302048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="721" mass="80029" checksum="F32BF351D2533437" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GLC5</accession>
    <name>A0AAJ0GLC5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1295 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_541812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717831.1">
        <property type="nucleotide sequence ID" value="XM_062869890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GLC5"/>
    <dbReference type="GeneID" id="87888719"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010721">
        <property type="entry name" value="UstE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251:SF23">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE (DUF1295)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06966">
        <property type="entry name" value="DUF1295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3302051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="360" mass="41305" checksum="33E03F1A2931976D" modified="2024-07-24" version="1">MALPHLRALEDCADFTKTVEPFIPQLYALPGKLLEVLTGHESLLRVYMQTNPLISGFALSVFLGAVFLVVAEVNRNYSQVDRCWSLLPTLYIAHFALWARLVGLPTRRIEAALLFSSIWSARLTYNYWRKGGYNIGSEDYRWELVRQRIPKAAFHVLNWTFISFMQSILLFLITAPVYKILLASTIEPNLTSADLASLAMELGLILTEYIADEQQWVYQSAKKLYKETGKVSRGFKQADLDRGFLTSGLWGYSRHPNFAAEQTIWFLLYQWSCYATKTLYSWAGLGPSFLILLFQGSTWLTEGITGGKYPEYSEYQRNVGMFAPKRLSAYKTPALKPKIIRTSELAEKQRQKEKEKQKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GLL1</accession>
    <name>A0AAJ0GLL1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_496623</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718352.1">
        <property type="nucleotide sequence ID" value="XM_062863916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GMC5"/>
    <dbReference type="GeneID" id="87882745"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="376"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="469"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3302572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="499" mass="55398" checksum="13125C3CF3145DB3" modified="2024-07-24" version="1">MALDLNADILGTLDRSALLEFAAFLRIALPPPAAYTSPSPSQSNTAVLPQTWLDAQQSTITTLSSELLARGTVTTTAIAMLSHSFTRLFRSNHHHHHHHHSHLSSSPILGGMKLCPAHKKLDADLLTHCFALLAAEVSVRCDVLKGYLSSCRRRRLHHAHSHHHQNSETAAAAQARKELKRMVEVLSGVASLYLSSEQFERCFGSTKPKYTFQKVQSGCPACVLAVVGGRREVLVALRGNMLGRAKGKEPRLLRLVEAWMEMFGGGVGVEAAIRRESDVLAQEVRNVRRVMHERKVQRRARKGKEEEDGGKSRHRGGMPAGAKVVDGVPMPQVKVYGDHPPSHNYPAFGLDGARRSDDLPAARRDEETGQWDIWPSSVSSSCSSSTSVDSDAELNANREFLPARRHWPQTHRTTTQRNASRRESESIYSTAGAGAVDRPSSILRDAPRPSEYTDVRLDDDESVRIFLDQRQSQSQSRSTRSRRQSQQSTSTDWADFYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ0GMF3_9PEZI</name>
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            <fullName evidence="5">CBM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="6" type="ORF">B0T15DRAFT_562604</name>
    </gene>
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        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718429.1">
        <property type="nucleotide sequence ID" value="XM_062870584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GMF3"/>
    <dbReference type="GeneID" id="87889413"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF13">
        <property type="entry name" value="DUF1996 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042468663" description="CBM1 domain-containing protein" evidence="4">
        <location>
            <begin position="24"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="5">
        <location>
            <begin position="367"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3302649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="398" mass="42803" checksum="C1A18824CE7DBFBF" modified="2024-07-24" version="1" fragment="single">MKVQQHSLLAAALALAGAPRVDAVLRFSCSELITERLDPLVFPGANPSPHLHQIVGGNMFNVTMDPARHNIGEEATCTTCTFSEDFSNYWTATLFFRARNGSFIRVPQRPNIGFESARGGGMTVYYTASYQNQKVTAFQPGFRMIVGNPTYRTAAEAARYRQLTFTCLDTMATRTGETTDMPDRPCKEGIMANVRFPTCWDGKNLDSPDHASHVAYPAAGTFESGGACPASHPVKIPQLFYEVIWDTRGFNDKANLWPEDGSQPFVWSYGDFTGYGTHGDYVFGWKGDALQRAMDANCDVYCPTLKEQGISAGNQCRVDRHVSENIDGWLSSLPGGVEITGPQPGTGTGGGNNGGGNNGGGNGGGSCQVAKWGQCGGQGYTGCTTCAASTSCTPQNQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GMG7</accession>
    <name>A0AAJ0GMG7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_562596</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718427.1">
        <property type="nucleotide sequence ID" value="XM_062870583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GMG7"/>
    <dbReference type="GeneID" id="87889412"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3302647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="284" mass="30210" checksum="3F702AB1905D7C81" modified="2024-07-24" version="1">MTASFTSLFKALESGIVTITTSQFKALNTDIAGRLESLTASSAASAELSSHVLGSLQQSVTESRDTEFRALQRIEKDLTETRNTQSLALAKIRESSALHASSCHAPASPYSKHGEAAGTARPGDAAERAEGMVNQTDPRKPPVSGDPGSGNIVSAAARQDAALPRPVAEETEAKKATAPRPVGVSAGVSTQPAVGAASAAKRPPEVTHHLETFEDSVKHSKNTDGRLLALTGEAEWRLDALRLGIKDAQLYVWVTEMHADINKREGGKNKPVRFMSNMQTPKYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GMH8</accession>
    <name>A0AAJ0GMH8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_497150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718474.1">
        <property type="nucleotide sequence ID" value="XM_062867243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GMH8"/>
    <dbReference type="GeneID" id="87886072"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3302694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="200" mass="22049" checksum="C71884CA300F4CB9" modified="2024-07-24" version="1">MSLRAPPGFPIAAGAQFYNFTHGGTTFTKVQLRFESCRRAKIAIPFNILTQLDSAIDIGRLMQSQNEGMTFYEFRRKPGQKIKYHIAEAIHPGSSCQWMDGNWSIVREPGLGAITFEMARGENGFDAKEYIRLTVAELRFEEGKKLLSCTAEYVVEGDRVPAGGEAPRLQDPSAPEEPGFPGFSAKGNTMVLAADLSPNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GN25</accession>
    <name>A0AAJ0GN25_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_495560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3302992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718772.1">
        <property type="nucleotide sequence ID" value="XM_062867110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GN25"/>
    <dbReference type="GeneID" id="87885939"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="1">
        <location>
            <begin position="79"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3302992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="266" mass="29668" checksum="AA53250C3E38F379" modified="2024-07-24" version="1">MPAKDPTTPGGDLLPHVVGDDGTVSIVALGGAMVTRVLAQAEAEALENSTNASTSTNTRQFHFEVVIHPDHPRLRGLPKPPTHFHPYQEEYFTVVQGALVVEIEGVERVVRPGDGEVVIPRRANHRLCFPSLVDLGRAQQEQGQEQEPVRFYVSGERTDTTAALDLVFFENWYAYQEEVVVHGKRLDLIQLLATWDAGASCLTLPRWVPFRSSVSRALGVVVGRWLGGLLGYQPFYRAWTTDWELACARMETSVFQRRFADRAKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GNQ5</accession>
    <name>A0AAJ0GNQ5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SIR2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_401292</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719107.1">
        <property type="nucleotide sequence ID" value="XM_062865101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GNQ5"/>
    <dbReference type="GeneID" id="87883930"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046970">
        <property type="term" value="F:histone H4K16 deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF9">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="9">
        <location>
            <begin position="170"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="334"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="525"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="361"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="535"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="395"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3303327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="553" mass="61364" checksum="03FBDFD247DFD960" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GP21</accession>
    <name>A0AAJ0GP21_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0T15DRAFT_401085</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719256.1">
        <property type="nucleotide sequence ID" value="XM_062865090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GP21"/>
    <dbReference type="GeneID" id="87883919"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000464">
        <property type="entry name" value="Zinc finger and SCAN domain containing 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000690">
        <property type="entry name" value="Zinc finger protein 354C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF20">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G10380)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="167"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="197"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="225"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="288"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="338"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="31"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="288"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="303"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3303476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="468" mass="49714" checksum="4A6FA7EDF3167EB3" modified="2024-07-24" version="1">MSQSPSAGGAMGIGSVLNIKAEPGMQQPSVEQQQDATAEQPQQPQQQQQQKQPATQPHQPHQQMLVERPNSAHGSDQSRYSGPMNASYPSPTVIGAVPLPPVPSANMAPAPMLHPDLRNVVPGMPPVQTVARPQPARAFPCSTCGKEFARRSDLARHERIHTGVRPHACDYPGCEKRFIQRSALTVHSRVHTGEKPHQCERCGKPFSDSSSLARHRRIHSGMRPYKCPYENCQKTFTRRTTLTRHQNHHSGTVEDAARARAEALAQGGLAQGASAAVVAAAAAEAVRANSQSSNEQASNQESPLNTPSRTMSMSPGADLAGINNLQYLSNNALPPHLRGDVHVGSPSPTASVGYNNGMRPTSHPTGYAPPQAIEPTIEHQQGPGSAAGSPHMASVGWASPGPVGSPAHSPNSNGYTYPDPADPYQSSTPVPQMFYNGAAPTRGSGSVEPGNPAYDAKGRQAELWTTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GP47</accession>
    <name>A0AAJ0GP47_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein transport protein sft1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_278262</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719314.1">
        <property type="nucleotide sequence ID" value="XM_062863547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GP47"/>
    <dbReference type="GeneID" id="87882376"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15853">
        <property type="entry name" value="SNARE_Bet1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039899">
        <property type="entry name" value="BET1_SNARE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3303534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="97" mass="10751" checksum="F487DDC6C4B68A3D" modified="2024-07-24" version="1">MSEAYERERQNNARLDELSAKVSALRGVTIDIYDSARSHEVIESTSETFSSMGTQLKGSASRLGRMAASGNKVAIFKLSGIIIGAVLVLYYIWRLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GPL4</accession>
    <name>A0AAJ0GPL4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_541163</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719541.1">
        <property type="nucleotide sequence ID" value="XM_062869839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GPL4"/>
    <dbReference type="GeneID" id="87888668"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3303761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="285" mass="32679" checksum="1DB408A6E78F9BF7" modified="2024-07-24" version="1">MPDLEDISYSRGRTIAAVTDYYIFLTRMYLKESHVVYPPADGWPSIVNADPAELRDLGKSDEVLALMAHLPYIRYPSDMVGASEDTPEVTPGSTVADWSDLIPRLSPSHGPRRESGEDLRILTEGRFHDISPPHVFGLFRNRDEAMVLDTELGIVHWQDCHGRIQFRGGSRGIEDVEWDLDDEVPEEEADWRRGAIAFEISDFFKLLKNQFIHLDWIPISPFTVRDGHDRDWPHEEGMMAMLEDVYREHGWADLTVYRKSDCLKAVQKALAEKYPESCCHHNPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GPU3</accession>
    <name>A0AAJ0GPU3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_535012</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RdRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="1"/>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3303922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719702.1">
        <property type="nucleotide sequence ID" value="XM_062869473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GPU3"/>
    <dbReference type="GeneID" id="87888302"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057503">
        <property type="entry name" value="PH_RdRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF17">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25358">
        <property type="entry name" value="PH_fung_RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RdRP-like PH" evidence="3">
        <location>
            <begin position="108"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="RDRP core" evidence="2">
        <location>
            <begin position="410"/>
            <end position="1006"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3303922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1210" mass="137319" checksum="8F11D177F783FC02" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GPX0</accession>
    <name>A0AAJ0GPX0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_400242</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
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        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
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                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
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                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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                <person name="Lalanne C."/>
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                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <strain evidence="8">CBS 333.67</strain>
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    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719886.1">
        <property type="nucleotide sequence ID" value="XM_062867974.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87886803"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="LSm14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DFDF"/>
    </dbReference>
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        <property type="entry name" value="FDF_dom"/>
    </dbReference>
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        <property type="entry name" value="FFD_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025609">
        <property type="entry name" value="Lsm14-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025768">
        <property type="entry name" value="TFG_box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13586">
        <property type="entry name" value="SCD6 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13586:SF0">
        <property type="entry name" value="TRAILER HITCH, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09532">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12701">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01199">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01271">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51512">
        <property type="entry name" value="DFDF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51536">
        <property type="entry name" value="TFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sm" evidence="7">
        <location>
            <begin position="6"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="DFDF" evidence="4">
        <location>
            <begin position="443"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="FFD box profile" evidence="5">
        <location>
            <begin position="502"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="TFG box profile" evidence="6">
        <location>
            <begin position="529"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="90"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="188"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="417"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="488"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="514"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="FFD box" evidence="1">
        <location>
            <begin position="502"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="TFG box" evidence="2">
        <location>
            <begin position="529"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="137"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="205"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="230"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="425"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="514"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="556"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00846"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51512"/>
        </source>
    </evidence>
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        </source>
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        <source>
            <dbReference type="PROSITE" id="PS51536"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3304106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="592" mass="61424" checksum="52CE15F0811F03CC" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQK4</accession>
    <name>A0AAJ0GQK4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">arginyltransferase</fullName>
            <ecNumber evidence="2">2.3.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_485979</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the R-transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.8" evidence="2"/>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720092.1">
        <property type="nucleotide sequence ID" value="XM_062866328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQK4"/>
    <dbReference type="GeneID" id="87885157"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004057">
        <property type="term" value="F:arginyl-tRNA--protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030700">
        <property type="entry name" value="N-end_Aminoacyl_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007472">
        <property type="entry name" value="N-end_Aminoacyl_Trfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007471">
        <property type="entry name" value="N-end_Aminoacyl_Trfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367">
        <property type="entry name" value="ARGININE-TRNA-PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367:SF1">
        <property type="entry name" value="ARGINYL-TRNA--PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04377">
        <property type="entry name" value="ATE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04376">
        <property type="entry name" value="ATE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-end aminoacyl transferase N-terminal" evidence="6">
        <location>
            <begin position="23"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="N-end rule aminoacyl transferase C-terminal" evidence="7">
        <location>
            <begin position="171"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="351"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="388"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3304312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="490" mass="55985" checksum="2911981587D3FDED" modified="2024-07-24" version="1">MQTPGATAARYSYLFPIGYSNSSECGYCRQTRSGQSTKRYSYYAIATSLTPAFYQKLVDRCWRRSGSLLYRPNQKHSCCPHYTLRLDSTQFHPAKDQRQAVNRFNRHIVGDTYVRDAARLHPRSRAEVRRRHNVFDLIERIHEPEAEMLKSPPSPDHVFSVTLEPDTFTEEKYEVFENYQRKVHGESPDRISRQGFKRFLCGSPLTRETMTGPDGTERQLGSFHQCYRIDGKLVAVGVLDLLPDCVSAVYFLYHESIHSLNPGKLGALREIALAREAGYRWWYPGYYVHNCAKMRYKIEYKPQYVLDPEDLRWYLLDKEALALFDKEHYVCFSRRQEDRGGATGRQVVMNSTDAESSGPRPAPLPLPAGAQTASPDPIKNQEMSEASAAEEDDEDDDEEDYGEAEEDAFLLASNMPGIPSLQEMQQVDMNRLLLRSDFSNNLIVASHLVIWDTEDIANFGTLKSRIAELVAAVGPDLIGEFVIDFRKRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQL1</accession>
    <name>A0AAJ0GQL1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Life-span regulatory factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_234661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720051.1">
        <property type="nucleotide sequence ID" value="XM_062862998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQL1"/>
    <dbReference type="GeneID" id="87881827"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024368">
        <property type="entry name" value="Ecl1/2/3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12855">
        <property type="entry name" value="Ecl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3304271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="149" mass="16269" checksum="BAA6DE46D7F11749" modified="2024-07-24" version="1">MSLDWTHQFCLGCDKQTDGATYCSESCRLADYEKTSPSTPSSAASSPALSSPPLDWTLPRPSSATSNRRFYLSPAYEFSSNALSSSPRRDSTRGHGLSPSASHTSLCSMRSTSSAAPLDAAQLSEKAARELRAYARSFESVRLQRRRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQP3</accession>
    <name>A0AAJ0GQP3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="6">PPIase</shortName>
            <ecNumber evidence="6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_239074</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cyclophilin-type PPIase family. PPIL3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="6"/>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720152.1">
        <property type="nucleotide sequence ID" value="XM_062863046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQP3"/>
    <dbReference type="GeneID" id="87881875"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01928">
        <property type="entry name" value="Cyclophilin_PPIL3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000041">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF2">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="7">
        <location>
            <begin position="6"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3304372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="167" mass="18253" checksum="4E5569C1C53F650F" modified="2024-07-24" version="1">MSVTLHTTHGDLKIEVFCESVPKTAENFLALCASSYYDGSPFHRLIPSFMVQTGAPAHPNPPDNPKGGRSIYGPTFEDEIRPGLRHHERGVVSMANKGPNTNGSQFFITFGPAPHLDGLNTVFGKLLGDESLATLAKIEALEVDKKHRPTEEVRIERVTVHANPLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GR28</accession>
    <name>A0AAJ0GR28_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_437115</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720377.1">
        <property type="nucleotide sequence ID" value="XM_062865843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GR28"/>
    <dbReference type="GeneID" id="87884672"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03750">
        <property type="entry name" value="proteasome_alpha_type_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1 2 3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="5">
        <location>
            <begin position="5"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="144"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3304597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="284" mass="30705" checksum="61E7692DCC747B46" modified="2024-07-24" version="1">MADRYSFSLTTFSPSGKLVQIEYALNAVNQGVTALGIKATNGIVLATEKKSSSPLADPSSLSKISLITPNIGMVYSGMGPDYRVLVDRARKVSHTGYKRIYNEYPPTRILVQDVARVMQEATQSGGVRPYGVSLLIAGWDEGILPEEDDPELQSKEEGEGEEKKKKVGGKTGGILKGGPMLYQVDPSGSYFPWKATAIGKSATTAKTFLEKRYTEGLELEDAVHIALLTLKETIEGEMNGETIEIGIVGPPADHLLGVEGVEGAVGPRFRKLTPQEIEDYLTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GR62</accession>
    <name>A0AAJ0GR62_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pentatricopeptide repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_512537</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720160.1">
        <property type="nucleotide sequence ID" value="XM_062867989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GR62"/>
    <dbReference type="GeneID" id="87886818"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3304380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="779" mass="87299" checksum="6C48F1A99184C071" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GR81</accession>
    <name>A0AAJ0GR81_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein SDA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_250292</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for 60S pre-ribosomal subunits export to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the SDA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720443.1">
        <property type="nucleotide sequence ID" value="XM_062863164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GR81"/>
    <dbReference type="GeneID" id="87881993"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027312">
        <property type="entry name" value="Sda1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048292">
        <property type="entry name" value="SDA1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007949">
        <property type="entry name" value="SDA1_MD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012977">
        <property type="entry name" value="SDA1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12730">
        <property type="entry name" value="HSDA/SDA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12730:SF0">
        <property type="entry name" value="PROTEIN SDA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21638">
        <property type="entry name" value="SDA1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05285">
        <property type="entry name" value="SDA1_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08158">
        <property type="entry name" value="SDA1_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SDA1 N-terminal" evidence="9">
        <location>
            <begin position="70"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="SDA1 middle" evidence="8">
        <location>
            <begin position="540"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="SDA1 C-terminal" evidence="10">
        <location>
            <begin position="692"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="503"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="649"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="523"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="657"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="687"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="730"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3304663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="744" mass="84836" checksum="8098210A7C39262D" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GRG9</accession>
    <name>A0AAJ0GRG9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_495237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720578.1">
        <property type="nucleotide sequence ID" value="XM_062867086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GRG9"/>
    <dbReference type="GeneID" id="87885915"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039323">
        <property type="entry name" value="ANKRD_45/46/60"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22677">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22677:SF4">
        <property type="entry name" value="USHER SYNDROME TYPE-1G PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="5"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="33"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="66"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3304798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="148" mass="15427" checksum="694285D615FFCAEA" modified="2024-07-24" version="1">MGGHVNVAAHDSHAEVVKLLVKKGADFKVANSYGSTPVNSAADNGYLDVVKFLVEKGADITLANDDGWTPVNSASSCGHLEVIKFLMLVNSAANQGPPEVVKFLVEKGANLEVANNAGWASVNAAANNGHLEVVKFLVDKGACDGRNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GRH2</accession>
    <name>A0AAJ0GRH2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_558827</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720588.1">
        <property type="nucleotide sequence ID" value="XM_062870487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GRH2"/>
    <dbReference type="GeneID" id="87889316"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3304808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="223" mass="25215" checksum="5A0D04E9588ACD61" modified="2024-07-24" version="1">MPSVENPPPSTPSQQPPDHQSRLVRARAVVTAHHGQYLDVLDRWQMLEIHPLIDTVLYYSGQAWLTCTTGANLDRGDHNEVFGDPSYLDKFIIAWMDAIPEGVVASIRGTKGCAEHWRCDINTNTGFFMMPVEYPEALVDHSKIDKQLESRRLNAKSPCFLMARSIPCLCSWLRMSDPTRRQTISRMATSVGNVHVYSSPTTAGKHYNVVFVVQPYRVTHMCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GRP2</accession>
    <name>A0AAJ0GRP2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_512947</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720637.1">
        <property type="nucleotide sequence ID" value="XM_062868013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GRP2"/>
    <dbReference type="GeneID" id="87886842"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050829">
        <property type="entry name" value="CorA_MIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47685">
        <property type="entry name" value="MAGNESIUM TRANSPORT PROTEIN CORA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47685:SF1">
        <property type="entry name" value="MAGNESIUM TRANSPORT PROTEIN CORA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="891"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="933"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="198"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="268"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="546"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="789"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1006"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="549"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="792"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1020"/>
            <end position="1038"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3304857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1094" mass="125483" checksum="4C73C277FF5A02DD" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GRZ5</accession>
    <name>A0AAJ0GRZ5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DHS-like NAD/FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_397238</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720828.1">
        <property type="nucleotide sequence ID" value="XM_062864887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GRZ5"/>
    <dbReference type="GeneID" id="87883716"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF8">
        <property type="entry name" value="NAD-DEPENDENT HISTONE DEACETYLASE HST3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="6">
        <location>
            <begin position="5"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="301"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="303"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="321"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3305048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="330" mass="36613" checksum="3B75EF4F0E63E384" modified="2024-07-24" version="1">MIHVEPQSYDYLDAIAHALRCARKVVVLTGAGISTAAGIPDYRSRGGLYAEHDTFCAAALRDPRRRADSFRSALHLYKLAKDSKPTEAHTFVTQLRNVGKLLRCYTQNVDQLHERAGLSTGLVENVKCVPLHGTIDSLRCSNCCKTLAWTEKLQARVTVGQEIPCPGCLDAPRRPGAPPRRSSTIGRLRPNIVYLEEEHPQGEDIAELINRDVSAGPDTVLIFGTSFEVSGPWDLVKRFAKVAGANGGKVIYVNRTKASRQGWKHVFDYWVEWECDSWVQDLMSRGLGPLPTQRLSLTLGGRVAKRPRGRQRRKAEDEPGSSFSNPILLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GSF7</accession>
    <name>A0AAJ0GSF7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cellobiose dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_193187</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721088.1">
        <property type="nucleotide sequence ID" value="XM_062862469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GSF7"/>
    <dbReference type="GeneID" id="87881298"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09630">
        <property type="entry name" value="CDH_like_cytochrome"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Cellobiose dehydrogenase, cytochrome domain"/>
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    </dbReference>
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        <property type="entry name" value="Cholesterol Oxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cellobiose_DH-like_cyt"/>
    </dbReference>
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        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053208">
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47190:SF2">
        <property type="entry name" value="CELLOBIOSE DEHYDROGENASE (AFU_ORTHOLOGUE AFUA_2G17620)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47190">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16010">
        <property type="entry name" value="CDH-cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
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    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042606648" evidence="3">
        <location>
            <begin position="24"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="4">
        <location>
            <begin position="330"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3305308.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="789" mass="84151" checksum="7C2203493E40D215" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GSM2</accession>
    <name>A0AAJ0GSM2_9PEZI</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_196185</name>
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    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAK3305407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062862511.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87881340"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
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        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
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        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
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        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF6">
        <property type="entry name" value="ACYL COA SYNTHETASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="56"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="2">
        <location>
            <begin position="478"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3305407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="584" mass="63664" checksum="EB1FC7E387371A1C" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GTS5</accession>
    <name>A0AAJ0GTS5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_494068</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721717.1">
        <property type="nucleotide sequence ID" value="XM_062866991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GTS5"/>
    <dbReference type="GeneID" id="87885820"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40903">
        <property type="entry name" value="GLYCINE-RICH CELL WALL STRUCTURAL PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40903:SF1">
        <property type="entry name" value="HYPHALLY REGULATED CELL WALL PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="543"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="252"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="330"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="551"/>
            <end position="564"/>
        </location>
    </feature>
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        <location>
            <begin position="592"/>
            <end position="604"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3305937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="604" mass="58339" checksum="BA31E734E2FA2720" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ0GUK0_9PEZI</name>
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            <fullName evidence="5">GPI anchored protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722122.1">
        <property type="nucleotide sequence ID" value="XM_062868940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GUK0"/>
    <dbReference type="GeneID" id="87887769"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042489940" description="GPI anchored protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="137"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="220"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3306342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="289" mass="29930" checksum="D359B3331807B774" modified="2024-07-24" version="1">MRQHHRICIAILQLLALVSAQEYQFFRWNVPGANLAADNVYRRQSPPPGYHPEFGSCGSGRTCEDACGPNWISCQASTSLSLFCYNQVDLNQTCCENGSGRACDSGYYCAWQTFGGRVWCCENGQSLEECGVPAGASTTATNTPTSSGDNNPDSSTSTSESPTSGPSSESTTARATLSATDSRCPASTVTLWATTTIMSTFSLAATTVTVTIPGPGWECSSSTSSSHGGPSGSASVSGTVTGPPSSSSTSYGPPASNATSTQTVVTASARMLTVNPLIAGLVLVPLLWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GV67</accession>
    <name>A0AAJ0GV67_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DHHA2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="6" type="ORF">B0T15DRAFT_151065</name>
    </gene>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
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    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722508.1">
        <property type="nucleotide sequence ID" value="XM_062861994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GV67"/>
    <dbReference type="GeneID" id="87880823"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="inorganic pyrophosphatase (n-terminal core)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004097">
        <property type="entry name" value="DHHA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038222">
        <property type="entry name" value="DHHA2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112">
        <property type="entry name" value="BNIP - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112:SF39">
        <property type="entry name" value="EG:152A3.5 PROTEIN (FBGN0003116_PN PROTEIN)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="DHH phosphoesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHHA2" evidence="5">
        <location>
            <begin position="261"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
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            <dbReference type="SMART" id="SM01131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="427" mass="46263" checksum="8A1BBFAA44D92186" modified="2024-07-24" version="1">MPASRTSLAGFLTAARAVLVSPPAQRPKPLTFVVGNESADLDSICSAIFVAYFRSHTPPYALHIPLSNLPRADLALRPELNAVLHPAHLSLDHLITLSDLPREEDLGVSDTRWLLVDHNVWTGRLAARFPSPVIVGCIDHHEDEGVVPTALPAGQPRVFAKCGSCMSLVVEQCKETWDRLSCEGGPTSKNPTHCDAALARIALAPILVDTANLTSKDKTTERDVSAVRVAESKLLSALSASSAEGEGGGGGGGEYERGKFYDELARLKEQIAGMPYRDVLRKDYKRWREGSLSLGVSSVVQGFEYVVQEVGDKDQAAFLGALRDWAAEQELDVVAVMTVSRPGGVFTRELLVWGLNEEGAKAAREFDLKYGSTLGLESWKGGELDGGSIQGTNSEGLRMCWTQRAIENSRKQVGPMLRAAMRESSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GVP6</accession>
    <name>A0AAJ0GVP6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_501348</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722500.1">
        <property type="nucleotide sequence ID" value="XM_062867396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GVP6"/>
    <dbReference type="GeneID" id="87886225"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3306720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="337" mass="36026" checksum="8C4BCDAD14F59618" modified="2024-07-24" version="1">MEPFTLQLANGGTVTGLANLPAASPTTTPRFKPLMVGLHGASYSSAYFDVDAKHTAALASDGLGVPWVAVDRPGYKGSTSFYPIPEQSSYHEVLGEWLHRYILPAVWQAFGEPRGCNSMVLLCHSLGAPGAVVAAALLARDDGEAKDAGNPPGYYPLSGIVASGFGTQASGGGNSSSGGNNDNRAHVPIPSNKEKEPEDDPELITFPAEVKDTMMLPAGTCDDAVYAHTARLNEPFPARERDDALPEAAFARRFRTHWAPLVRVPVMVAVAERDPWWEADDEHTSHLAALFAASRKVEARVIPGAPHNLEMSHWAQAWYARCFGFGMECAVGFALAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ0GWX0_9PEZI</name>
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            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">B0T15DRAFT_395256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723421.1">
        <property type="nucleotide sequence ID" value="XM_062864771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GWX0"/>
    <dbReference type="GeneID" id="87883600"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053185">
        <property type="entry name" value="SET_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332:SF6">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3307641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="266" mass="30315" checksum="26481CDF4ED66996" modified="2024-07-24" version="1">MVDLPALLISVSFLGDTKPHHRRRVLKQAINQLPEATRSRVYGLSRGTAEHEVDAVLGPNSHTVMVGDEEVHVGLFTEVARINHSCRPNAYYRFSERRLTMEVVAYHAIEPGDEITLSYVPLETPSPVRRQYLKSHWGFDCTCPLCTGPTPDLDESEAWRQKIKSLRETIANARSEGFYHDAIVMTEEWLMFGEWDMQPPLMAAYYDTLADLYFLKGDMVNATRHARMAVDEWVRLGSVDDEGLEKARVFLGRLLLEASDGRHRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GXK3</accession>
    <name>A0AAJ0GXK3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">methionyl-tRNA formyltransferase</fullName>
            <ecNumber evidence="1">2.1.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_523133</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.9" evidence="1"/>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3307962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723742.1">
        <property type="nucleotide sequence ID" value="XM_062868670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GXK3"/>
    <dbReference type="GeneID" id="87887499"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004479">
        <property type="term" value="F:methionyl-tRNA formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd08646">
        <property type="entry name" value="FMT_core_Met-tRNA-FMT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041711">
        <property type="entry name" value="Met-tRNA-FMT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11138">
        <property type="entry name" value="METHIONYL-TRNA FORMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11138:SF5">
        <property type="entry name" value="METHIONYL-TRNA FORMYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Formyl transferase N-terminal" evidence="2">
        <location>
            <begin position="33"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3307962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="396" mass="43383" checksum="A33DFBD169EB23FF" modified="2024-07-24" version="1">MLHLTRSLLRTAARPIRWRQSYSIATKASEPLRILFCGSDKFSCESLQALHDEHKRDTDLIRSIDVVVRPSKPTGRGNKVMSEVPIRTLAERLNLPVHVRDTFTGWAMPKPHGDPINLIIAVSFGLFVPPRLINASKYGGLNVHPSLLPDLRGPAPIHHALLAERTHTGISIQTLSPRAFDEGTILLQTPSPGIPIPPQCTPQQLHDLLAPEGARMLVEALRRRLHVPPYRPVRENDYDDNDDDEGRRLRHAPKITTADRQIRWTASGAGRVALQARVLGPLWSHLAIEEGVGKRVILEDVEEAVVGRSGEGEGRGGGARHVTWLQKSDGAGKAGVDPALGKAEVVTLRYVVGGSGTGKSILVQMVDGSWLRVGRIKVEGSISKPARGVLESMRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GXU1</accession>
    <name>A0AAJ0GXU1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_508654</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723936.1">
        <property type="nucleotide sequence ID" value="XM_062867739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GXU1"/>
    <dbReference type="GeneID" id="87886568"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031833">
        <property type="entry name" value="DUF4748"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41800">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41800:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15932">
        <property type="entry name" value="DUF4748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3308156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="116" mass="13067" checksum="178DF49C1EDAFDA5" modified="2024-07-24" version="1">MNTVKSFWLGWGSLCAAGGVAYYVAKRNINADRQSRLEEQRRRKAVADSLEHSQNIASRGYDEPARTDMAYSPSQESSSDPAPTRHAPVTEQQRIVEKSKYESSQPFRSPKGDRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GXY2</accession>
    <name>A0AAJ0GXY2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_428827</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat PWP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723939.1">
        <property type="nucleotide sequence ID" value="XM_062865695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GXY2"/>
    <dbReference type="GeneID" id="87884524"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000470">
        <property type="entry name" value="Periodic tryptophan protein 2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001292">
        <property type="entry name" value="Periodic tryptophan protein 2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027145">
        <property type="entry name" value="PWP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858:SF0">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="147"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="191"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="336"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="378"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="464"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="6">
        <location>
            <begin position="741"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="640"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="648"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3308159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="898" mass="99558" checksum="E881FFFD4B2B764A" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GY48</accession>
    <name>A0AAJ0GY48_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_550331</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724111.1">
        <property type="nucleotide sequence ID" value="XM_062870243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GY48"/>
    <dbReference type="GeneID" id="87889072"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3308331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="475" mass="54445" checksum="0EC2C19705145DFE" modified="2024-07-24" version="1">MSKGDDWRVCLAYQGPARTAQSSARPGHATNIVTLFLIVDYMSDWARDVYRTAVIGEMRTLAAPNTNLPTVFTDTDIFSSRDVVLDPDLVADWENSDEVPEQDHRNPQGGVQFSPNSVRPVALTPDQISSIEERWTGHSRLKAPFHLTDKRLYTVYDVNYSLLPSWDQVRELCLIAIEAQAFDAGRQVQVESSRKEQAVCGTQQRGHPVHQPAGTDSYLDTTFTRKGNLEPDLPFFRTSGSSEIQKAAPQNVGGAATLADDDLEARICVNLVRDSRERPNQSELGLIIKRTFEDHDVYHTTRDHGTLNPWNVKQSRDIWNLTCSYGVFFSYGRSSFVKWLRKLDEPLSTRQVSPRGRHATGRVMFEREYSPWHDPRLIYRIYCREKKKFFKRLFVAEVTAWARIAQERIRQGNDCYPLCATVDPYRRAGDSVLELLVKWKSGRETWELYEDVAQSEREALDEYERLRGQVTTDTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GY88</accession>
    <name>A0AAJ0GY88_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_104933</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724087.1">
        <property type="nucleotide sequence ID" value="XM_062861413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GY88"/>
    <dbReference type="GeneID" id="87880242"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042483415" description="FAD-binding PCMH-type domain-containing protein" evidence="6">
        <location>
            <begin position="20"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="75"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3308307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="521" mass="55932" checksum="0ED3AB88630DDDAE" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GY93</accession>
    <name>A0AAJ0GY93_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_565571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724161.1">
        <property type="nucleotide sequence ID" value="XM_062870671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GY93"/>
    <dbReference type="GeneID" id="87889500"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3308381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="462" mass="51961" checksum="3B79060BF2A2FF79" modified="2024-07-24" version="1">MDRLPVEITANIITYFIADVRGSYDSDMGSDGGPAPSLAPYASVSRVWQHCVEAVTFAHITLTLERLASPLAAQALTPERLYRFVRSVHVDVLLPLYDERARHRIEDDADKAANDAVFTDVVRKVFALLSSASASGMGVQQLVVADVATTDYRPKIELSLTARCLSDTKQPEARYVTNIRYEGSYLELRPAAGESVEDVANRLPEVHCIPKFHMSGLEKVDWELCDNERRDAGLRKRLRAEFAETLPMLPSSLRDFKLRLALHKLSQRLVCFTLVAEVGREAIWPSGPAVLNHRHVPFWPIISRYSIDPGAIAPSGEWRFRQRTGGSADSEDEIDSPDSDYSGPPGDEILYPFREEHDLDLVGPFMPALRDMHFSLSPPVGTDRCLSIWYDVTDNVSPDIDCRVGMGHRQLARRGAKLVFECEPVFYLDQEMIQAWREAAKSHTGTESGLQMFTTDYRWQAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GYX8</accession>
    <name>A0AAJ0GYX8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_115899</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
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                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="366" mass="40542" checksum="FBB4C4CE9BC0C363" modified="2024-07-24" version="1">MNPDDPSESFIRRTPSPQPHPPPHPLLAWIPTHESSSHLVSHHLTFSNLVLFNRANLFLFNEATFASVSLHEADSVWVHADDRHENEGRASSTSRPPRPTRPNGPFDSLDVLWTGAWAEGEGHLPVSTLFLDDSEDHEPASAFIEVSIGKRLELPTPCSENSPSSPGDAASIAISSDSGQVDGKDGYGFQLFKQVLRRLIIAHQAETAECNTSQPTPRQGDREAGTSQPGRQAPTDSPAVTKQRKRQRGSDQDSGEDEDGCDGRRAKQPTGTSRDAFRRQKFLACPFGKLDPNKYWECFLKRITTISYVKQHLSRKHTPDFFCPRCYTIFAQEPVYETHVLAAACSRGPSARLDGISPHQSRQLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H015</accession>
    <name>A0AAJ0H015_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribonuclease-III-like-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_526692</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3309252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725032.1">
        <property type="nucleotide sequence ID" value="XM_062868919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H015"/>
    <dbReference type="GeneID" id="87887748"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1520.10:FF:000018">
        <property type="entry name" value="RNase III domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040030">
        <property type="entry name" value="Ribosomal_mL57"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28160">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L15, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28160:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase III" evidence="2">
        <location>
            <begin position="117"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3309252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="266" mass="29967" checksum="3AA49C88C9432481" modified="2024-07-24" version="1">MALNTSRSVLSSTCTALRICSGSAPSTAQRLGQTSVRQLSTSAARRTDAVEATTQQQEQQPRPRWSYTPERMKGPGFSINIVKDPSRTIWQNNQDPAKLDAMYNRLLGPKGDRMLPDEIKWLAITHKSFDQGRRGFNTRLAYFGRLIVALETTRHIMVTPASSREFPDEFGREPFRHHALANIDKLNIRQPQHIASKENLRRLAMDVGLLEVIRWKPRMPENLESSGLTVVLNTSLFAIIGAISLQHGAEVAQQVFRDKILRRLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H020</accession>
    <name>A0AAJ0H020_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">RecF/RecN/SMC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_122750</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724700.1">
        <property type="nucleotide sequence ID" value="XM_062861647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H020"/>
    <dbReference type="GeneID" id="87880476"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03275">
        <property type="entry name" value="ABC_SMC1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028468">
        <property type="entry name" value="Smc1_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937:SF12">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecF/RecN/SMC N-terminal" evidence="9">
        <location>
            <begin position="4"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="76"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3308920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="187" mass="20879" checksum="2A9C63D09B296984" modified="2024-07-24" version="1">MGKLIRLELFNFKSYKGHHTLLFGDSYFTSIIGPNGSGKSNSMDAISFVLGIKSSHLRSSHLRELVYRGRVMKTSKIQDDGTAAPTTNGETSGHVNGDDEDSSQRASRNDPKTAWVMAVYEDDAGDEQRWKRTITSNGTSEYRINDRVVTAQQYNEALEEENILIKARNFLVFQGDVEAIASQSPRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H0K0</accession>
    <name>A0AAJ0H0K0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-hydroxyanthranilate 3,4-dioxygenase</fullName>
            <ecNumber evidence="9">1.13.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">3-hydroxyanthranilate oxygenase</fullName>
            <shortName evidence="9">3-HAO</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">3-hydroxyanthranilic acid dioxygenase</fullName>
            <shortName evidence="9">HAD</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Biosynthesis of nicotinic acid protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BNA1</name>
        <name evidence="10" type="ORF">B0T15DRAFT_8287</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>3-hydroxyanthranilate + O2 = (2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde</text>
            <dbReference type="Rhea" id="RHEA:17953"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:36559"/>
            <dbReference type="ChEBI" id="CHEBI:77612"/>
            <dbReference type="EC" id="1.13.11.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the 3-HAO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.6" evidence="9"/>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H0K0"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000334">
        <property type="term" value="F:3-hydroxyanthranilate 3,4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006569">
        <property type="term" value="P:L-tryptophan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06123">
        <property type="entry name" value="cupin_HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000093">
        <property type="entry name" value="3-hydroxyanthranilate 3,4-dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00825">
        <property type="entry name" value="3_HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010329">
        <property type="entry name" value="3hydroanth_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03037">
        <property type="entry name" value="anthran_nbaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15497">
        <property type="entry name" value="3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15497:SF1">
        <property type="entry name" value="3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06052">
        <property type="entry name" value="3-HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 10" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 9" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>O2</name>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3309613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="183" mass="20719" checksum="152730472EA467C8" modified="2024-07-24" version="1">MLAPPVNLPKWLEENSHLLKPPINNYCVYNADFTVMIVGGPNARTDYHINQTPEWFYQYKGAMLLKVVDEGDTFRDIVIREGEMFLLPPNTPHNPVRFADTVGIVLEQKRPADSVDRMRWYCPREGCGAVVHEAAFHCTDLGTQIKEAVEAFKADEGLRTCKKCGEVADWCPKPGSIRDPNLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H0R6</accession>
    <name>A0AAJ0H0R6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_406141</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725422.1">
        <property type="nucleotide sequence ID" value="XM_062865307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H0R6"/>
    <dbReference type="GeneID" id="87884136"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00273">
        <property type="entry name" value="Ribosomal_eL20"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_eL20"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_eL20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021138">
        <property type="entry name" value="Ribosomal_eL20_eukaryotes"/>
    </dbReference>
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        <property type="entry name" value="60S RIBOSOMAL PROTEIN L18A"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF01775">
        <property type="entry name" value="Ribosomal_L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RplX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL20" evidence="5">
        <location>
            <begin position="4"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3309642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="174" mass="20355" checksum="105312FCD0C31D70" modified="2024-07-24" version="1">MGRLQEYQVIGRHLPTEANPTPALYRMRIFAPNEVVAKSRFWYFLRGLRKVKKATGEIVSVNVISEKHPLKVKNFGIWIRYDSRSGTHNMYKEYRETSRTGAVEALYADMAARHRARFRSIHILRVVELEKTDDIKRPYIKQLVQKKLSFPLPHRVPKISNKKIFSATRPSTFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H175</accession>
    <name>A0AAJ0H175_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histidine kinase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_506355</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725375.1">
        <property type="nucleotide sequence ID" value="XM_062867564.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87886393"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050956">
        <property type="entry name" value="2C_system_His_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058846">
        <property type="entry name" value="PAS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719:SF30">
        <property type="entry name" value="TWO-COMPONENT SYSTEM RESPONSE REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26131">
        <property type="entry name" value="PAS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
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    </dbReference>
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        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="6">
        <location>
            <begin position="897"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="7">
        <location>
            <begin position="970"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="1046"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="1404"/>
            <end position="1586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="104"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="261"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="438"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1318"/>
            <end position="1396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1454"/>
            <end position="1504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1747"/>
            <end position="1778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="261"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="1515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3309595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1788" mass="196375" checksum="C1F036DFEE4D2D1A" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H1A9</accession>
    <name>A0AAJ0H1A9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_481299</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725484.1">
        <property type="nucleotide sequence ID" value="XM_062866016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H1A9"/>
    <dbReference type="GeneID" id="87884845"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF20">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="26"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3309704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="493" mass="54290" checksum="8C602B8C43BDFC8B" modified="2024-07-24" version="1">MSTSSISLSPISLSIPQHQDTRPKGACVDCKRLKKRCDRASPACTNCAKASRTCEFKDLSEDGLLSPISSAKSIDTLTFGTLLDILITKQRVKEAVTLYFRGVNTWFTIVEKASYERQLDTAWDKLPAEASVLALCMALMARPPNQKSSKIGDTVYHTTKAILGLVQSKAPMSVPLLQAELLVAMYEFSQSMPQQAYLSLGRCLQMTKAFGWHGAVFWAEDRKASMARDLKLYSILWWAIVYLDCLLNVGYQDQTFPMHTAGLEAVSMIPLPENFDQHLASSSPFQLGAQGQEQGFRDSNGDRIEGMIVPEATSAWYLSRVLEQLSDPALPGNVDTKTLSTMIWQHAQDISAAKWRAGDRNAAVGTDLIALMKLNHPGLLGGADPLSLLSDPQAVQRIRVLTTVIHGKAGKIAASEHRLSTGVEAPCWAFAMSYASLLLISHGNGVLQDADWFSRVENLMTSIEKVSKRWIIAARYCETVKIALENRLNGYAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H1R1</accession>
    <name>A0AAJ0H1R1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Peroxisomal membrane protein PEX13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Peroxin-13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B0T15DRAFT_517742</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="13">Interacts (via SH3 domain) with PEX14 (via SH3-binding motif); forming the PEX13-PEX14 docking complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peroxin-13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725989.1">
        <property type="nucleotide sequence ID" value="XM_062868327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H1R1"/>
    <dbReference type="GeneID" id="87887156"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11771">
        <property type="entry name" value="SH3_Pex13p_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000128">
        <property type="entry name" value="Peroxisomal membrane protein (Pex13)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007223">
        <property type="entry name" value="Peroxin-13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035463">
        <property type="entry name" value="Pex13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19332">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19332:SF1">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04088">
        <property type="entry name" value="Peroxin-13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SH3" evidence="16">
        <location>
            <begin position="307"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="389"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="16"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="398"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00065871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK3310209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="443" mass="46322" checksum="0F89E9B5357C7BF8" modified="2024-07-24" version="1">MASPPKPWERQGAGPGASAPAISAAAANTTTAPATTAAGAATTTTSSHTTPAIPARPASLTASVNQNAAAYSRPYGATPYGGMGGYGTAYSSPYSSPYSRLGGYGGYGGGMYGSYGGYGGMYGGGMYGGMPGAMPGPADPNNPESLTQRFGMSTQATFQMLEGIVGAFGGLAQMLESTYMATHSSFFAMVSVAEQFGNLRDTLGSVLGIFTLMRWIRTLIAKLTGRPPPVDATALTPAAFARFEGRRSPVPEGGPPKPSRKPLLFFLLAAFGLPYVMSKLIRSMAANVEEEERRRQLVAAQQMLDPSKLEFCRVLYDFSPAAQGQAAVQGVDLEVHKGDLVAVLSKCDPLGNPSEWWKCRARDGGIGYLPSTFLEVLRKPGQPIAAIKGMPESESSRANTMTSSTASPPSPLPQAANNNPPAMPSTKVGDVTVESFQKSQFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H1R6</accession>
    <name>A0AAJ0H1R6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_26000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725917.1">
        <property type="nucleotide sequence ID" value="XM_062863315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H1R6"/>
    <dbReference type="GeneID" id="87882144"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001080">
        <property type="term" value="P:nitrogen catabolite activation of transcription from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF4">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN DAL81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="14"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3310137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="452" mass="48896" checksum="5EDAEBDCF15843D3" modified="2024-07-24" version="1">MDGTKSSDQPKRRACDECRGRKLACSKEIDGCARCKREGIKCVYSPQKRMGRPRKHRPVELAEPPAKVSEPREAPTVEAPPVIVPDFEFDSSIGMDLDLSFLDMSGADVNFLDLVDPNSQYLPPPAQTSIEQGTAGYQKLPQLGNTPGGDFWSMGSGVPGDINFDGPLCASTPPPAPEITPEEVAQMLSADLETLPSLSPPSSSSPSTHGSPESDGPPLCGCLSKLYLALASLQTLPKDVSEAMRVARTATRIAHDTILCPVCGDPPIDPAGKPPLQAYQNMMMLGALLPSLSNAYMRILGMVDAEAAAADKDHRNIRFTLSGYGGLWGLLAKLDPVECNASERLEGAMLEPTLWRLAVRALLKIDVYGIDGMTADIKCRFGDIQQPGLKDIIKMMEERSRRRHEQLDAMVAAGIVQKVNCDYVPLTATGEKPTCLRIIDIAKRSMDELVIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H1T2</accession>
    <name>A0AAJ0H1T2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_498405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726038.1">
        <property type="nucleotide sequence ID" value="XM_062867314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H1T2"/>
    <dbReference type="GeneID" id="87886143"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36839">
        <property type="entry name" value="METALLO-BETA-LACTAMASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G12770)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36839:SF1">
        <property type="entry name" value="METALLO-BETA-LACTAMASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G12770)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="89"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3310258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="315" mass="35417" checksum="9F9922D3D0859C6D" modified="2024-07-24" version="1">MTDTSRYLVCNTCGTQHPTADRTALTRCFICDDPRQYTPPSGQSFTTLADLRSSSAGEDQRQRHNEFLPLIQDDPRFTCIVTKPAFAIGQRAILIRTPRGNVLWDCVSYIDDDTVARVSNEMGGIQAMVISHPHFYSTHLEWAERFGCPVYLAREDRGWLARRDEQRQVFLDGVETRVEINGEDTGVRVVKLGGHFPGSLVLLYDGHLFTADTLMMTPAGRANWAVDALGNPRERPQGINTFSFLWSIPNMIPLSADEIARMWGILRNYDFKSAHGLFMGADIADENIKARVLESMQIQVRAMGHAGHALMRETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H213</accession>
    <name>A0AAJ0H213_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DHS-like NAD/FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_385792</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726171.1">
        <property type="nucleotide sequence ID" value="XM_062864297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H213"/>
    <dbReference type="GeneID" id="87883126"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01407">
        <property type="entry name" value="SIR2-fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47651:SF17">
        <property type="entry name" value="DEACETYLASE SIRTUIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47651">
        <property type="entry name" value="NAD-DEPENDENT HISTONE DEACETYLASE HST4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="6">
        <location>
            <begin position="97"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="441"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="487"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="527"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="560"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="617"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3310391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="656" mass="71443" checksum="03D56D970BF7EB91" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H2E1</accession>
    <name>A0AAJ0H2E1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0T15DRAFT_42871</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726366.1">
        <property type="nucleotide sequence ID" value="XM_062865693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H2E1"/>
    <dbReference type="GeneID" id="87884522"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090422">
        <property type="term" value="F:thiamine pyrophosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000011">
        <property type="entry name" value="Mitochondrial thiamine pyrophosphate carrier 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 13" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="12"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="122"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="215"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3310586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="322" mass="35155" checksum="3B7C4AD1CBCDB9F1" modified="2024-07-24" version="1">MSVKGDHLKDEGSRLQVTAAGATAGLISRFVIAPLDVVKIRLQLQTHSLSDPLSQRDLRGGPIYKGTLPTLRHIVRHEGITGLWKGNVPAELLYVCYSAVQFTTYRWTTLLLHSAFGNNALPQSVESFVAGAAGGGAATAVTYPLDLLRTRFAAQGIERVYTGLWRAVVQIQREEGARGFFRGLGPGMAQIVPYMGCFFAVYETLRPHLMGLDLPFGGGGAVAGTIASVMAKTGTFPLDLVRKRIQVQGPTRSRYVHKNIPVYEGTLGAMRTIVRTEGVRGLYRGLTVSLFKAAPASAVTMWTYERALRFYTGLGQRQEQRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H2G2</accession>
    <name>A0AAJ0H2G2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA polymerase lambda</fullName>
            <ecNumber evidence="4">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">B0T15DRAFT_518954</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA polymerase type-X family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="4"/>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726398.1">
        <property type="nucleotide sequence ID" value="XM_062868403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H2G2"/>
    <dbReference type="GeneID" id="87887232"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00141">
        <property type="entry name" value="NT_POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000010">
        <property type="entry name" value="DNA polymerase lambda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.210.10:FF:000001">
        <property type="entry name" value="DNA polymerase lambda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.110:FF:000005">
        <property type="entry name" value="DNA polymerase POL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.210.10">
        <property type="entry name" value="DNA polymerase, thumb domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002054">
        <property type="entry name" value="DNA-dir_DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028207">
        <property type="entry name" value="DNA_pol_B_palm_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018944">
        <property type="entry name" value="DNA_pol_lambd_fingers_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037160">
        <property type="entry name" value="DNA_Pol_thumb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022312">
        <property type="entry name" value="DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002008">
        <property type="entry name" value="DNA_pol_X_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="HHH_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029398">
        <property type="entry name" value="PolB_thumb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276:SF28">
        <property type="entry name" value="DNA POLYMERASE LAMBDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276">
        <property type="entry name" value="DNA POLYMERASE TYPE-X FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14792">
        <property type="entry name" value="DNA_pol_B_palm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14791">
        <property type="entry name" value="DNA_pol_B_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10391">
        <property type="entry name" value="DNA_pol_lambd_f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00869">
        <property type="entry name" value="DNAPOLX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00870">
        <property type="entry name" value="DNAPOLXBETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00483">
        <property type="entry name" value="POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81585">
        <property type="entry name" value="PsbU/PolX domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="12" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="14" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BRCT" evidence="19">
        <location>
            <begin position="204"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="64"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="150"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="314"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="431"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="743"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="159"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="347"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="359"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="370"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="437"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="746"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; Schiff-base intermediate with DNA; for 5'-dRP lyase activity" evidence="17">
        <location>
            <position position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR622312-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAK3310618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="860" mass="96159" checksum="3B54C583F2956EEA" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H2M2</accession>
    <name>A0AAJ0H2M2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Exocyst complex component Sec10-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_518358</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726160.1">
        <property type="nucleotide sequence ID" value="XM_062868356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H2M2"/>
    <dbReference type="GeneID" id="87887185"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009976">
        <property type="entry name" value="Sec10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048627">
        <property type="entry name" value="Sec10_HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048625">
        <property type="entry name" value="Sec10_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <end position="193"/>
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        </location>
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        </location>
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            <begin position="136"/>
            <end position="148"/>
        </location>
    </feature>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF20667"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3310380.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
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                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
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        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        <lineage>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062868441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H3G5"/>
    <dbReference type="GeneID" id="87887270"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039931">
        <property type="entry name" value="EEIG1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019448">
        <property type="entry name" value="NT-C2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21456:SF1">
        <property type="entry name" value="C2 NT-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21456">
        <property type="entry name" value="FAMILY WITH SEQUENCE SIMILARITY 102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10358">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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    </feature>
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            <end position="422"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3310830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="458" mass="49530" checksum="9EA880AB85A5E782" modified="2024-07-24" version="1">MVKWHLPHSIHGEHRGRTQKCPILNHRVEYNYSKVIPVRIAVDRSGNLCECPVEFEVVQEFSAGGLNGGSGRDEKITLGTVRLNLSEYVEESEGILRDGTTAAAIKEALASPVQKSASHHRKRSSQSNAGSSPRTSHDDERPTTDAVQDGVVRRYLMQESKINSTLKISILMIQVDGDRNYVAPPPKSAFVFGGIAGLVSGDVFEPVDTGATTPGHAPSSFSGKSRDVFEVQDMYRRALAASWASQPGELPADRCIEDIFAGGEGFASPPRSSHHARGHSRHHHRPHSAVAGHGRAGPGDAPPKAPRGDDSGSVSDEEDSGSLMGTLRPRDLARLRSMRHLRDQSVASDRSVATVLGGGGERDLDRESSRGIGLGANGPLREPFPSFSSLPMHRREESKITHAGGGLRSRSSSLVSLASTLGSERERGREGFKRAREVDEFEVRDDLVAWTIPGPHPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H3R4</accession>
    <name>A0AAJ0H3R4_9PEZI</name>
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        <submittedName>
            <fullName evidence="13">Glycosyltransferase family 32 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0T15DRAFT_389037</name>
    </gene>
    <organism evidence="13 14">
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        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endomembrane system</location>
            <topology evidence="10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726740.1">
        <property type="nucleotide sequence ID" value="XM_062864470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H3R4"/>
    <dbReference type="GeneID" id="87883299"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.20:FF:000002">
        <property type="entry name" value="Initiation-specific alpha-1,6-mannosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039367">
        <property type="entry name" value="Och1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834:SF1">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042576700" evidence="12">
        <location>
            <begin position="24"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="41"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3310960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="377" mass="43123" checksum="FC2E607B66D344EB" modified="2024-07-24" version="1">MLTFKRALVAAAFFITLLYITTRSTSPAAALSPVDIPKVEVGSESRQTSQTTGSSDEKTSNSNAVHAGANRNRPLQQGQQPMRDMSKMTLSEKLAYQFPYDVEMKFPAYIWQTWKWTPAHGEFQFREQEATWTEQHPGFIHEVITDQVAVNLLRLLYASVPEVLEAYHALPLPVLKADFFRYLILLARGGIYSDIDTYAIRSALEWIPESVPRNTVGLVIGIEADPDRPDWKEWYSRRIQFCQWTIQSKPGHPVLREIVTRITDQTLRRKRAGSLKDIIDKNVIEFTGPALWTDVIFEYFNDPRYFDMAQSPGPIDWHNFTGMEMTKKVGDVIVLPITSFSPGVQQMGAKDYDDPMAFVKHDFEGTWKPESERHIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H3S9</accession>
    <name>A0AAJ0H3S9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_571464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726790.1">
        <property type="nucleotide sequence ID" value="XM_062870859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H3S9"/>
    <dbReference type="GeneID" id="87889688"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042528879" evidence="1">
        <location>
            <begin position="18"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3311010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="128" mass="14167" checksum="957D6C6D207EE7C0" modified="2024-07-24" version="1">MAGVCCSPGVLFSGVSLQLCLLPAPACRPMRNAKSMFRVPSLWAILSLRATGGRKLRRRAEPSGRTRMDQGLESVGQVKADAMLQSSAAPRLLVDESRKQKCSPQRIPWGYDRKTQFYSESRTPRISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H3Z2</accession>
    <name>A0AAJ0H3Z2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_408599</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726860.1">
        <property type="nucleotide sequence ID" value="XM_062865341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H3Z2"/>
    <dbReference type="GeneID" id="87884170"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF195">
        <property type="entry name" value="PEP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
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        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="167"/>
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            <begin position="179"/>
            <end position="202"/>
        </location>
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        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="5">
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            <end position="270"/>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="301"/>
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    <feature type="transmembrane region" description="Helical" evidence="5">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="5">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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        </location>
    </feature>
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        <location>
            <begin position="55"/>
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        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3311080.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="591" mass="62529" checksum="14F57297027401EA" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ0H448_9PEZI</name>
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        <recommendedName>
            <fullName evidence="4">NodB homology domain-containing protein</fullName>
        </recommendedName>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAK3311170.1"/>
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Polysacc_deacetylase_ArnD"/>
    </dbReference>
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        <property type="entry name" value="4-DEOXY-4-FORMAMIDO-L-ARABINOSE-PHOSPHOUNDECAPRENOL DEFORMYLASE ARND-RELATED"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3311170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="142" mass="16069" checksum="E85A10211415AAB3" modified="2024-07-24" version="1">MRDEPARGLGTAELERQLREVQGLIEQAYRAEGREPPPPGTAGRGRRYYRPGSGFFSSRIRGVARRLGYRVVLGSIYPHDAQIGWAWVNARHILSMLSPGGIIICHDRRSWTEPMLRRVLPEMKKRGYRAVTLSELLAEVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H4E2</accession>
    <name>A0AAJ0H4E2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GPR1/FUN34/yaaH family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_549189</name>
    </gene>
    <organism evidence="7 8">
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            <taxon>Sordariomycetidae</taxon>
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    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727336.1">
        <property type="nucleotide sequence ID" value="XM_062870212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H4E2"/>
    <dbReference type="GeneID" id="87889041"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015123">
        <property type="term" value="F:acetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051633">
        <property type="entry name" value="AceTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123:SF4">
        <property type="entry name" value="PROTEIN ALCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3311556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="279" mass="30540" checksum="4B4A95D44D45F770" modified="2024-07-24" version="1">MATSGPSTATNGVNMAVDEEKGLHRTQTGVTMSPELFEKLYLTPKVPHVGDYNRRFANPTALGFVGFVISTFTFSIVCMGWGGAQGFSPVVGIFFFVGPVLLIFAMVFEWIMGNFFPMMVMGLFSVFWLSFGMLQLPTLQLGSAYASAADPTGLASPEYNSVVALYLIVWGFALFTFFIFTCKINAVFAAIFCLVSVAAWVLSGAYWKLSWGDYDAAGKLQKAGGALLFVVAALGWYMCFIIMAGEMRITLNLPVGDLSHLWPKTDVELAAAERREHRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H4X9</accession>
    <name>A0AAJ0H4X9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_427903</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727345.1">
        <property type="nucleotide sequence ID" value="XM_062865676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H4X9"/>
    <dbReference type="GeneID" id="87884505"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF48">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="8"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3311565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="517" mass="57532" checksum="4C7D23132CCAF499" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LXV2</accession>
    <name>A0AAJ0LXV2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_318728</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HesB/IscA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717420.1">
        <property type="nucleotide sequence ID" value="XM_062864029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LXV2"/>
    <dbReference type="GeneID" id="87882858"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="ATAP_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43011">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43011:SF1">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core" evidence="2">
        <location>
            <begin position="123"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3301640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="265" mass="28328" checksum="3F4933BBD6F7DEE3" modified="2024-07-24" version="1">MTRLRCAKPPATAGLFLQLCMRRQAVSSGLLILDVLLPRSFRAVGAPAICTYHASSTAWRPSPRYILPPSSRGPWRGPRARLALPEARTVSGGPAPRLFSTSFPLGATHAIFNSQVDDDGKEMTLEITPRAAKRLSEIISKDSNPNLALRIQVESGGCHGFQYVMKLVTLPPSLPTADSLASAAAAEDASAAVRQDDTIFTYSADDSSPGDLTAPKIILDRPSLELLKGSKVDFTMELIGSQFKIVDNPLATSSCGCGTSFDIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LXX2</accession>
    <name>A0AAJ0LXX2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Nuclear distribution protein PAC1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Lissencephaly-1 homolog</fullName>
            <shortName evidence="13">LIS-1</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">nudF homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">PAC1</name>
        <name evidence="13" type="synonym">LIS1</name>
        <name evidence="16" type="ORF">B0T15DRAFT_321096</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in mitochondrial fission. Acts as an adapter protein required to form mitochondrial fission complexes. Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Self-associates. Interacts with NDL1 and dynein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
            <location evidence="13">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
            <location evidence="13">Cytoskeleton</location>
            <location evidence="13">Spindle pole</location>
        </subcellularLocation>
        <text evidence="13">Localizes to the plus ends of microtubules at the hyphal tip and the mitotic spindle poles.</text>
    </comment>
    <comment type="domain">
        <text evidence="13">Dimerization mediated by the LisH domain may be required to activate dynein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the WD repeat LIS1/nudF family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the WD repeat MDV1/CAF4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LXX2"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070840">
        <property type="term" value="F:dynein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051012">
        <property type="term" value="P:microtubule sliding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023052">
        <property type="term" value="P:signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000342">
        <property type="entry name" value="Nuclear distribution protein PAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.960.30:FF:000002">
        <property type="entry name" value="Platelet-activating factor acetylhydrolase ib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03141">
        <property type="entry name" value="lis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017252">
        <property type="entry name" value="Dynein_regulator_LIS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037190">
        <property type="entry name" value="LIS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056795">
        <property type="entry name" value="PAC1-like_LisH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24951">
        <property type="entry name" value="LisH_PAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037647">
        <property type="entry name" value="Dynein_regulator_Lis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109925">
        <property type="entry name" value="Lissencephaly-1 protein (Lis-1, PAF-AH alpha) N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 13" id="KW-0132">Cell division</keyword>
    <keyword evidence="8 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 13" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 13" id="KW-0498">Mitosis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 13" id="KW-0813">Transport</keyword>
    <keyword evidence="3 14" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="PAC1-like LisH-like dimerisation" evidence="15">
        <location>
            <begin position="8"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="114"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="156"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="201"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="247"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="354"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF24951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3301683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="450" mass="49193" checksum="A44C10B1537F7377" modified="2024-07-24" version="1">MNRGILTDRQADELHKSIIAYLSANNLSTAAETLRAELSLREDVFDPDTTAKYRSLLEKKWTSTVRLQKKVMQLESVNSELQSKVESARLSPNLSKRNQDPVDWLPQSPPRHLLESHQATVNCLAFHPTFSSLASGCDDSLIKIWDWELGELERTLKGHTRAVLDVDYGGPKGSILLASCSSDSTIKLWDPADGYKNIRTLAGHDHSVSAVRFIAGSAKSRNMLVSASGDKTLKIWDITAGYCIRTLQGHTAWVRDVCSSVDGRYLLSAGSDQTARLWDISAAADGEDKLVLPGHENGIGCCAFAPAASYGYLAKLAGLKKPPPASSTAEFMATGARDKTIKLWDVRGVCFKTLVGHDNWVSGIVFHPGGKYLLSVADDKTLRCWDLSQDGRCVKVLADAHGQFITCVRWAPPVVKKEGEQQAGEDSGEVQIRRVIATGSVDKAVRIFAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LY34</accession>
    <name>A0AAJ0LY34_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">D-2-hydroxyglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="11">1.1.99.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B0T15DRAFT_541601</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the oxidation of D-2-hydroxyglutarate (D-2-HG) to alpha-ketoglutarate. Also catalyzes the oxidation of other D-2-hydroxyacids, such as D-malate (D-MAL) and D-lactate (D-LAC). Exhibits high activities towards D-2-HG and D-MAL but a very weak activity towards D-LAC.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(R)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13521"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(R)-malate + A = oxaloacetate + AH2</text>
            <dbReference type="Rhea" id="RHEA:67460"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15588"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:67461"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.39" evidence="11"/>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3301982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717762.1">
        <property type="nucleotide sequence ID" value="XM_062869872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LY34"/>
    <dbReference type="GeneID" id="87888701"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051990">
        <property type="term" value="F:(R)-2-hydroxyglutarate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2190:FF:000001">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2740:FF:000002">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.10:FF:000002">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000053">
        <property type="entry name" value="D-lactate dehydrogenase (Cytochrome), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.45.10:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051264">
        <property type="entry name" value="FAD-oxidored/transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43716">
        <property type="entry name" value="D-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43716:SF1">
        <property type="entry name" value="D-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="16">
        <location>
            <begin position="120"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK3301982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="552" mass="60345" checksum="719B1ADCB5BF8C75" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LY68</accession>
    <name>A0AAJ0LY68_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_291301</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717867.1">
        <property type="nucleotide sequence ID" value="XM_062863715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LY68"/>
    <dbReference type="GeneID" id="87882544"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF692">
        <property type="entry name" value="TRANSMEMBRANE AMINO ACID TRANSPORTER FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="457"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="499"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="543"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="602"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="625"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="659"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="10">
        <location>
            <begin position="282"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="110"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="134"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="167"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3302087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="697" mass="75036" checksum="5204AB70E4B926F7" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LYI9</accession>
    <name>A0AAJ0LYI9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ClpP/crotonase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_305188</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718211.1">
        <property type="nucleotide sequence ID" value="XM_062863858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LYI9"/>
    <dbReference type="GeneID" id="87882687"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004165">
        <property type="term" value="F:delta(3)-delta(2)-enoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000048">
        <property type="entry name" value="3,2-trans-enoyl-CoA isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051053">
        <property type="entry name" value="ECH/Chromodomain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684:SF1">
        <property type="entry name" value="ENOYL-COA DELTA ISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3302431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="293" mass="31964" checksum="C1FD37BB5B3F96BC" modified="2024-07-24" version="1">MASPPVIKLEYNGRLAIITIDNEKKLNALTQNDYYDLAQKLREVATHDEVYITLLIGKGRYFSAGADVTVVRPTFPTSSSPSAFQGQDSASPPPAEPSGHRVFLQNFVAFNLNIAQAFYTHPKILVVGLNGPVVGLSAALISLADFIYAAPHAFLLTPFSSLGLVTEGVASRALVQRLGLAKANEALIMSKRISCEELAATGFVNKVFAECGRGPGEDEKFRALVLREIDERLGEHLVGESLLGIKKLIRQPEREVMDRQNVAEVFGGLERFMSGVPQEEFAKIASGKKRHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LYJ5</accession>
    <name>A0AAJ0LYJ5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_487517</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718108.1">
        <property type="nucleotide sequence ID" value="XM_062866443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LYJ5"/>
    <dbReference type="GeneID" id="87885272"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01786">
        <property type="entry name" value="RA_STE50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09533">
        <property type="entry name" value="SAM_Ste50-like_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051569">
        <property type="entry name" value="SHANK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24135:SF28">
        <property type="entry name" value="LD13733P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24135">
        <property type="entry name" value="SH3 AND MULTIPLE ANKYRIN REPEAT DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM" evidence="2">
        <location>
            <begin position="68"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="3">
        <location>
            <begin position="383"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="292"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3302328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="490" mass="52932" checksum="689EB46DC214EC29" modified="2024-07-24" version="1">MNFDSGTAYAESDADDEYERDIHGSSPIATDVENSPIDSDPPSAEHTPTTYGYRSSADRLPETIISEWTAEECADFIASIGVQQYADRFIENDIVGEALVALQHEDLKAMGITSVGHRLTILKSVYDVKKAQDVPIEPDHYMPPTAETQAQSSNATLKDIKHLVEQLRLRDERMALFEQDLRRLTEDFRRLREDMLPALRLAKNAQQPLPTLNNGQTYESTLSPPAPTPSTAGQGSAGLNRQYSTKKIMLGTTPKATSPTHLQTSHDRSIVEQTLDPSSAAERAVLSSSHLAAMNGNAGSSSSPSYPSPNMPSPTSPPTGGMMTGTTLGARSYRGEQTTPSSRSTFTSNDHYSQPQSGTAPRRMQTPAPETPGASSNASVEIFKSFRVSMDDPCYKVLPAALKKYQINAPWDQYALYIVYGDQERCLGLDEKPLILFKQLDKEGKKPMFMLRKTAPPDGGAGEAPGSAGLAGASARGGTGTGYDPPGGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LYY9</accession>
    <name>A0AAJ0LYY9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Acyl carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0T15DRAFT_486426</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3302839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718619.1">
        <property type="nucleotide sequence ID" value="XM_062866357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LYY9"/>
    <dbReference type="GeneID" id="87885186"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099128">
        <property type="term" value="C:mitochondrial [2Fe-2S] assembly complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000035">
        <property type="term" value="F:acyl binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000003">
        <property type="entry name" value="Acyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00517">
        <property type="entry name" value="acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002148">
        <property type="entry name" value="PRK00982.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="ACYL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863:SF28">
        <property type="entry name" value="ACYL CARRIER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13 14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 14" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Carrier" evidence="15">
        <location>
            <begin position="62"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3302839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="141" mass="15317" checksum="496DA8F772BA21C3" modified="2024-07-24" version="1">MFRTAILRSAAAATRTAMRPISSAAGRRLAIAPAPKVASFVPKPVSWQAVRCYASGGSLERQEVYERIKQLLSGFDKVNDPANITENAHFANDLGLDSLDTVEVVMAIEEEFSIEIPDKDADAIHSVDKAVEYILSQPDAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M0D0</accession>
    <name>A0AAJ0M0D0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_503616</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720117.1">
        <property type="nucleotide sequence ID" value="XM_062867476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M0D0"/>
    <dbReference type="GeneID" id="87886305"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3304337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="138" mass="14825" checksum="7FD803A8F1808D08" modified="2024-07-24" version="1">MPIITIAEIIEVMTVGGIFAGTITEWCKDHPGPGCVNKHHLLNNLSDVGPCNVPMYNFDICNTQLHDQANNGNKVWTSVPFPGVARFENVPPACMNLAVALTGACTADGPRPTPCGSACMEYTGLSDDQMRQLSSYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M0D4</accession>
    <name>A0AAJ0M0D4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Post-SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_238014</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720131.1">
        <property type="nucleotide sequence ID" value="XM_062863035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M0D4"/>
    <dbReference type="GeneID" id="87881864"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053201">
        <property type="entry name" value="Flavunoidine_N-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12350">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12350:SF19">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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            <end position="137"/>
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        </location>
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        <source>
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        </source>
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        <source>
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        </source>
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        </source>
    </evidence>
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        <source>
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        <source>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
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                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
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                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
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                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
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                <person name="Steindorff A."/>
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                <person name="Ament-Velasquez S.L."/>
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                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
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        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Bonometti L."/>
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                <person name="Haridas S."/>
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                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
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                <person name="Chen C."/>
                <person name="Yanf M."/>
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                <person name="Steindorff A."/>
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                <person name="Martin F."/>
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                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
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                <person name="Hiltunen Thoren M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">Acyl-CoA N-acyltransferase</fullName>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
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                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
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                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
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                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
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                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAK3304804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3304804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="257" mass="28580" checksum="5ADD8D40FE2FBCD7" modified="2024-07-24" version="1">MPFLVLPALIPDIRAVYDVYFAAFTTDPDGRRLLDILFPGGVASDEFRDAHAKGTLAWWHTSDTQYTFKCLDPATGEVVGMALCDVFVTTPKVEEKKKKERVMPEVGWLQGKEKERAERVLAPLWKARERIWGGGRYIYIHAFAVHPKHQGRGAGAALVQALIDLSDSTGLPIYLESSPGSQGLYRKMGFMQVPGNIARVVHDAEVLGTEEDVEVPLMIKLPASVTASSSEKGKSVEDVYVQWYWQRGTTDEKVKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">NACHT domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="3" type="ORF">B0T15DRAFT_188014</name>
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    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720840.1">
        <property type="nucleotide sequence ID" value="XM_062862407.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87881236"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015969">
        <property type="term" value="P:guanosine tetraphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05399">
        <property type="entry name" value="NT_Rel-Spo_like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Beta Polymerase, domain 2"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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        <property type="entry name" value="NPHP3-like_N"/>
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    <dbReference type="InterPro" id="IPR043519">
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN-RELATED"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="540"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3305060.1"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="881" mass="99629" checksum="AF5B6D5DD5E44CCF" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M172</accession>
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        <recommendedName>
            <fullName evidence="2">DUF7143 domain-containing protein</fullName>
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        </lineage>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721001.1">
        <property type="nucleotide sequence ID" value="XM_062866942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M172"/>
    <dbReference type="GeneID" id="87885771"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055567">
        <property type="entry name" value="DUF7143"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37592">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37592:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23631">
        <property type="entry name" value="DUF7143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042490134" description="DUF7143 domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7143" evidence="2">
        <location>
            <begin position="31"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3305221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="190" mass="20018" checksum="6541F340D6D63CE2" modified="2024-07-24" version="1">MKVFTALTFGAGLVFAAPLISERQAGSACFVIGNQALPKEVADVVTSIQPRITCDTSRKTLSGVPDVSSGGVSFSSVNFASSSQTPLQFALSKFATPTPLRSADLAAFQKQLDVYLATEAGIRSVGGSLAIKVPKFFLQFQVSRIQTAQGNPPTAPGLQVDHLLQKVLKNAPRESQALRDQVTALAKVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M1K3</accession>
    <name>A0AAJ0M1K3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyruvate kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_532871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
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                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
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                <person name="Kuo A."/>
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                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
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                <person name="Ng V."/>
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                <person name="Ament-Velasquez S.L."/>
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        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Bonometti L."/>
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                <person name="Cros-Aarteil S."/>
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
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                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
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                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 333.67</strain>
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    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Andreopoulos B."/>
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            <strain evidence="3">CBS 333.67</strain>
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        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
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                <person name="Kuo A."/>
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                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
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                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
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                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
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                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
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    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
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    <proteinExistence type="predicted"/>
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    </feature>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="162" mass="17929" checksum="2ED47433BC9CD61A" modified="2024-07-24" version="1">MSHCHSTPHMSRSPPLNLFSAIGFGVGTKFASKDMMPGWESHSWGYHGDDGKKFHGGQGTSYSSTFGKGDTVKCRVDQSARTMFFTKNGVDLGEALNDLRGRLYPVLGIMSHGAKVATNFTWEPPALPAQDKGDKHDSGITSLPPRQWRRGSREHFRHANRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M2H1</accession>
    <name>A0AAJ0M2H1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_527418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722293.1">
        <property type="nucleotide sequence ID" value="XM_062868971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M2H1"/>
    <dbReference type="GeneID" id="87887800"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3306513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="98" mass="10495" checksum="D1069F3B7C5537D4" modified="2024-07-24" version="1">MSSSITEPTAGPGQTQPWRKWWPPETETMAEDELKAKPWINWKPDPKQPNAKPWLQWVPRDAHIVHSRSDSGPGSGSGSGSGSAPVSPVPPSSNAEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M2L4</accession>
    <name>A0AAJ0M2L4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7053 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_140623</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722219.1">
        <property type="nucleotide sequence ID" value="XM_062861873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M2L4"/>
    <dbReference type="GeneID" id="87880702"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055481">
        <property type="entry name" value="DUF7053"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38117:SF1">
        <property type="entry name" value="DUF3074 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38117">
        <property type="entry name" value="NACHT AND WD40 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23155">
        <property type="entry name" value="DUF7053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7053" evidence="1">
        <location>
            <begin position="8"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3306439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="186" mass="20426" checksum="B5DA152637EE9A58" modified="2024-07-24" version="1">MSPPQPFTVVTRVPIPRTLAPERVIAALQTYEALITPNPYLERFERRPVQTAEVANDSFFLSDGKNLQAFVVYDRVPIIPGVGSWATKEVAVPCIFQSVEHGVRCCAHAQGGVTVRSSYEVRRRGEITDGPELEVGSGDGDYELIDISNVECSALVKLFVKTRLASGHLVLLRQVIADLVQQPAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M3K1</accession>
    <name>A0AAJ0M3K1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_364774</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3307775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723555.1">
        <property type="nucleotide sequence ID" value="XM_062864168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M3K1"/>
    <dbReference type="GeneID" id="87882997"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF7">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="46"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="80"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="616"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="645"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3307775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="656" mass="72916" checksum="53E7785459B5CB35" modified="2024-07-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M3N4</accession>
    <name>A0AAJ0M3N4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_493039</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GILT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723344.1">
        <property type="nucleotide sequence ID" value="XM_062866912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M3N4"/>
    <dbReference type="GeneID" id="87885741"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016671">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004911">
        <property type="entry name" value="Interferon-induced_GILT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234">
        <property type="entry name" value="GAMMA-INTERFERON INDUCIBLE LYSOSOMAL THIOL REDUCTASE GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234:SF8">
        <property type="entry name" value="GAMMA-INTERFERON-INDUCIBLE LYSOSOMAL THIOL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03227">
        <property type="entry name" value="GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3307564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="181" mass="20066" checksum="306E3C1C74EB9F3D" modified="2024-07-24" version="1">MDEKHAPMPPPIRRGLSPTRLILAVSYLSLAAVTYWYFLTHAAIRSLAPLNPPPSAASLDLVPLEAHIMSKCPDAKDCLRDLVLPAMQKVHDKVNFTLSFIGSPTDSDDGVACKHGPEECLGNIIELCAQRLYPDAKTFLGFTMCLTRDYKHIPQRSLVEDCALEHAIDFSKLNDGRRRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M472</accession>
    <name>A0AAJ0M472_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="9">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_524396</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724196.1">
        <property type="nucleotide sequence ID" value="XM_062868763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M472"/>
    <dbReference type="GeneID" id="87887592"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000037">
        <property type="entry name" value="alpha-1,2-Mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF89">
        <property type="entry name" value="ALPHA-1,2-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="40"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="330"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="450"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="515"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="603"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="407"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3308416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="614" mass="69995" checksum="9D9262896D2D6640" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M4W0</accession>
    <name>A0AAJ0M4W0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Domain found in IF2B/IF5-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_526296</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3309138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724918.1">
        <property type="nucleotide sequence ID" value="XM_062868899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M4W0"/>
    <dbReference type="GeneID" id="87887728"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.170:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016190">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_Zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001:SF3">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="Translation initiation factor 2 beta, aIF2beta, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75689">
        <property type="entry name" value="Zinc-binding domain of translation initiation factor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation initiation factor IF2/IF5" evidence="5">
        <location>
            <begin position="205"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="34"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3309138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="338" mass="36834" checksum="2967B9C144A60BEA" modified="2024-07-24" version="1">MSTEEPTLQRRASRKSVAFTEEKLVVDADGSVTVMATPNDDTKDTAVSHTPRTPPLAAALRASTDASQAPADGTAADGADANPDGLDLSLMKKKKKKVKKEDGESGDGAAAAGGEEAIDLSMKKKKKKKVVKEEDEFAKKLEALNLEGGESAEAPAEGDVQDGDMEKGTGIWAHDETRTISYNPLLSRFFTLLAQKNPDHASTGTRSYKIPPPQCLREGNKKTIFANLPEICKRMKRADEHVTAYLFAELGTSGSVDGSRRLVIKGRFQQKQIENVLRTYIIEYVTCKTCRSPNTELSKGENRLYFITCNSCGSRRSVQAIKTGFSAQVGKRRKMQQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M589</accession>
    <name>A0AAJ0M589_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Complex III subunit 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0T15DRAFT_515851</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The complex plays an important role in the uptake of multiple carbon sources present in different host niches.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the UQCR10/QCR9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725353.1">
        <property type="nucleotide sequence ID" value="XM_062868223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M589"/>
    <dbReference type="GeneID" id="87887052"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.260:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.260">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008027">
        <property type="entry name" value="QCR9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036656">
        <property type="entry name" value="QCR9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12980:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12980">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX, SUBUNIT X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05365">
        <property type="entry name" value="UCR_UQCRX_QCR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81514">
        <property type="entry name" value="Subunit X (non-heme 7 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3309573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="64" mass="7551" checksum="C70CE701DF9C9780" modified="2024-07-24" version="1">MVAKTIYDAFFRRNSVMLGVVFAGAFAFELGYDNMMNRVWDNINRGRQWKDIRHKYVQGGDDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M5L5</accession>
    <name>A0AAJ0M5L5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_506482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725520.1">
        <property type="nucleotide sequence ID" value="XM_062867582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M5L5"/>
    <dbReference type="GeneID" id="87886411"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3309740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="233" mass="26046" checksum="A208A84080AB38CA" modified="2024-07-24" version="1">MGRRPQIGGSQSVEQARFVGVSLQSVKNRRPPDLGPLQPATSQVREEIQPEPLILVAIGTAVRDDEETPTENDSWRGNQQQYSQWQWWKKEEEGSEGTNSPPSHLPEILRIQGQHAVLGKQMSLSYSLYDTRQNGFLFLQAALPAGRNAARLDMRQWDGAWEETKWYDTRSTGSIVLPTEANQGFQVDFPDIPGAIHNYLVAVVNESGLALMLRNGQGSVVGIDFVYRSGIWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M5L9</accession>
    <name>A0AAJ0M5L9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin-conjugating enzyme E2 2</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">E2 ubiquitin-conjugating enzyme 11</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ubiquitin carrier protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ubiquitin-protein ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B0T15DRAFT_481283</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="14">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725457.1">
        <property type="nucleotide sequence ID" value="XM_062866014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M5L9"/>
    <dbReference type="GeneID" id="87884843"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23791">
        <property type="entry name" value="UBCc_UBE2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000068">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2-20 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 14" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="16">
        <location>
            <begin position="32"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="13">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00080142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK3309677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="180" mass="19751" checksum="6A86D3F16949EC2D" modified="2024-07-24" version="1">MSFIEDSQNSAPDSVQTSKLGAARKGAEPGQNAAKRLQTELMQLMTSPAPGVSAFPSADGNLLSWRATIEGPEDTPYSGLSFKLSFEFPSNYPYAPPTVLFRTPIYHPNVDFSGRICLDILKDKWTAAYNTQTVLLSLQSLLGEPNNASPLNGEAAELWDKDPALFKTKVMDRHKDIEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M5M8</accession>
    <name>A0AAJ0M5M8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_21119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725786.1">
        <property type="nucleotide sequence ID" value="XM_062862674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M5M8"/>
    <dbReference type="GeneID" id="87881503"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3310006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="228" mass="25072" checksum="C185529E10301FAE" modified="2024-07-24" version="1">MPSIAQESPTVHGSKKRTRKVIPIPPGKRRRRSVDIDVGGEGGDPMQQSPSGSPPQERQHQQPHQLQRRQQPRSKNTSLEDDAEEEETTSPANLMSRCHICFRRPDLKTYKNSFADCESCGQRTCYVCIRECLGPGSNIDTMQAAEPVPPNTITTTTAAAATTTTSSVEGDTSFTMTDADAEANNEQVWTRESAAGSRHRRMVCSRCCVERGQDGEVVCLGCLQYLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M5Z9</accession>
    <name>A0AAJ0M5Z9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ML-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_23454</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transient receptor potential (TRP) ion channel family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725862.1">
        <property type="nucleotide sequence ID" value="XM_062862997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M5Z9"/>
    <dbReference type="GeneID" id="87881826"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010308">
        <property type="entry name" value="TRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040241">
        <property type="entry name" value="TRP_Flc/Pkd2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032800">
        <property type="entry name" value="TRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145:SF5">
        <property type="entry name" value="DUF907 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G06100)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06011">
        <property type="entry name" value="TRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14558">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01320">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042568606" description="ML-like domain-containing protein" evidence="9">
        <location>
            <begin position="25"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="368"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="446"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="508"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="534"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="564"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="596"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="ML-like" evidence="10">
        <location>
            <begin position="26"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="695"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="758"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3310082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="778" mass="82909" checksum="5DFEF2B6B0D93677" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M677</accession>
    <name>A0AAJ0M677_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Something about silencing, SAS, complex subunit 4-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_518927</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726386.1">
        <property type="nucleotide sequence ID" value="XM_062868401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M677"/>
    <dbReference type="GeneID" id="87887230"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033255">
        <property type="term" value="C:SAS acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038988">
        <property type="entry name" value="Sas4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029184">
        <property type="entry name" value="Sas4_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38422">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38422:SF1">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15460">
        <property type="entry name" value="SAS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Something about silencing protein 4" evidence="2">
        <location>
            <begin position="287"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="556"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="474"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="567"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3310606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="580" mass="65291" checksum="DDE8A834C1D7A3DD" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M6N8</accession>
    <name>A0AAJ0M6N8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein L24e-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_519799</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726674.1">
        <property type="nucleotide sequence ID" value="XM_062868453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M6N8"/>
    <dbReference type="GeneID" id="87887282"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.20:FF:000002">
        <property type="entry name" value="60S ribosomal protein L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="entry name" value="Ribosomal protein L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056366">
        <property type="entry name" value="Ribosomal_eL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_eL24-rel_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023442">
        <property type="entry name" value="Ribosomal_eL24_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01073">
        <property type="entry name" value="RIBOSOMAL_L24E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL24-related N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="115"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="115"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="130"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3310894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="161" mass="18000" checksum="21AE9AE7B943269E" modified="2024-07-24" version="1">MRTYDDTFSGQRIYPGKGKLYVRGDSKIFRFQNGKSESLFLQRKNPRRIAWTVLYRRQHRKGISEEVAKKRTRRTVKSQRAIVGASLDVIKEKRSMRPEARSAARLAAIKESKEKKQAAQAAKKAEKAKSAAQAAKGQSQGRIASKQGAKGAPVKVAAKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M6Z6</accession>
    <name>A0AAJ0M6Z6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal trichothecene efflux pump</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_389937</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727168.1">
        <property type="nucleotide sequence ID" value="XM_062864517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M6Z6"/>
    <dbReference type="GeneID" id="87883346"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS drug efflux pump"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010573">
        <property type="entry name" value="MFS_Str1/Tri12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF109">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06609">
        <property type="entry name" value="TRI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3311388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="519" mass="55411" checksum="73344B74FF99EFAB" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M766</accession>
    <name>A0AAJ0M766_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CMGC protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_409577</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727361.1">
        <property type="nucleotide sequence ID" value="XM_062865353.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87884182"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="63"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3311581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="420" mass="48798" checksum="4AE497A0F6BE182A" modified="2024-07-24" version="1">MVSLVKWMRRVLRPDPWKPLQFPTAGFEEFPASEVLEEEFFHEFKKGDYYPVNIGDLLDSDTYQVVGKLGFGRTSSVWLARDLRARKYVALKIFTRWEGETCRDEFQTCKAIEEAGHSHKGRSYLRTALDQFTIDRPGGLPHHCLVQKPLWDTWGDLLYRNPNRRFSQALLKVSLQQLLSALDYLHTECKLVHTDISEHNILHSIVDKDILKAYVKEEFKTPTPRKHVTLDDGTTVPVYASHRFGMPKHFGHIVLSDFGEAVRGDVKHNHHAQPNQYRAPEVQLGASWSYPIDIWNVGCLIWSVFEGRHLFRGRDPVNHRYSTRAHLAEVVALLGPPPLDLLRRGWRSKEFFSEDGQWIANVTIPRDNSLEKAEHFLTGSDKTMFLNFVRGMLAWRPEDRKTARELLKDPWLNAWEDMDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M7I3</accession>
    <name>A0AAJ0M7I3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_508259</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727512.1">
        <property type="nucleotide sequence ID" value="XM_062867707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M7I3"/>
    <dbReference type="GeneID" id="87886536"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24124">
        <property type="entry name" value="ANKYRIN REPEAT FAMILY A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24124:SF14">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_25, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="10"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3311732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="170" mass="18466" checksum="CC6F98DEB05319E7" modified="2024-07-24" version="1">MALIDAYNPEGHTALHSAVITQNVECARILLESGASIEDIARNGRTPLTLAIIHNSHAIQKLFVDRRFKGPQVLAVIAEHTDTETMSIIGLSLPLKLSLNPAADGFAAGREILRQRTDYNERLGHAFEEMLSSISTAKEDAAASNVRSGLLGHLSTEPSFCEELAGQSWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GKL3</accession>
    <name>A0AAJ0GKL3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_544304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717441.1">
        <property type="nucleotide sequence ID" value="XM_062870056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GKL3"/>
    <dbReference type="GeneID" id="87888885"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3301661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="82" mass="8859" checksum="8859A8B250AAFDC9" modified="2024-07-24" version="1">MTDATAISYHNMIAIFFHIYSVGLSLPTKTTPATRLRTDDILHLFAYSLPCILFGGSALDLGIASNRPAQVEGCLTMSLPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GKP1</accession>
    <name>A0AAJ0GKP1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="18">RAD5-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B0T15DRAFT_423413</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717442.1">
        <property type="nucleotide sequence ID" value="XM_062865589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GKP1"/>
    <dbReference type="GeneID" id="87884418"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014905">
        <property type="entry name" value="HIRAN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF22">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08797">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24975">
        <property type="entry name" value="UBA_Rad5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00910">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="517"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="911"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="1001"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="385"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="153"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="385"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="398"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK3301662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1167" mass="130631" checksum="1DD253BB57B8811D" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GKZ9</accession>
    <name>A0AAJ0GKZ9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_325662</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717650.1">
        <property type="nucleotide sequence ID" value="XM_062864112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GKZ9"/>
    <dbReference type="GeneID" id="87882941"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3301870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="317" mass="34481" checksum="8EF6DCEF249D0EF6" modified="2024-07-24" version="1">MEPSRLPYTLPSDAVWFITGCSSGIGKSLAELVVAKGQRLVATARKLEDLAYLPDNPPNSSILKLRVDVASKQSVDDAVAAALAHFARLDVVVNNAGYSLRGDTENAPEEAARHQLETMFWGTVRLTRHAMRIMREVNPAAPGGQQGGVVVNVSSMGGRAAFPGNAFYHAAKFAVEGFTESVAREVRPEWNIHFCLVEPGGVRTGFTGHRMQRIEVHPAYAAPDTPSRLLDKYIDDPEASKNFADVDDVTKAMYSIVASGKEIPLRVPIGPDAWGVLKIENEKNGKALDEWKDFAISAGKAGQFESLDFMTGRESRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GL51</accession>
    <name>A0AAJ0GL51_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Calponin homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_541535</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha-actinin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3301945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717725.1">
        <property type="nucleotide sequence ID" value="XM_062869863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GL51"/>
    <dbReference type="GeneID" id="87888692"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21215">
        <property type="entry name" value="CH_SpAIN1-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21291">
        <property type="entry name" value="CH_SpAIN1-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000138">
        <property type="entry name" value="Alpha-actinin, sarcomeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000097">
        <property type="entry name" value="Alpha-actinin, sarcomeric (F-actin cross linking protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000279">
        <property type="entry name" value="Calponin domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000223">
        <property type="entry name" value="Related to alpha-actinin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000030">
        <property type="entry name" value="Related to alpha-actinin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000077">
        <property type="entry name" value="Related to alpha-actinin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014837">
        <property type="entry name" value="EF-hand_Ca_insen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08726">
        <property type="entry name" value="EFhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01184">
        <property type="entry name" value="efhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="11"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="125"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="485"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="628"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="654"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3301945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="665" mass="76026" checksum="3B1EC2D1D96DC337" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GLQ3</accession>
    <name>A0AAJ0GLQ3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Poly(A) polymerase</fullName>
            <ecNumber evidence="11">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B0T15DRAFT_422224</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Polymerase that creates the 3'-poly(A) tail of mRNA's.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11332"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17347"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173115"/>
            <dbReference type="EC" id="2.7.7.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 2 magnesium ions. Also active with manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the poly(A) polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="11"/>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718039.1">
        <property type="nucleotide sequence ID" value="XM_062865567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GLQ3"/>
    <dbReference type="GeneID" id="87884396"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000002">
        <property type="entry name" value="Poly(A) polymerase alpha, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.10:FF:000001">
        <property type="entry name" value="Putative poly(A) polymerase gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.590">
        <property type="entry name" value="Poly(A) polymerase predicted RNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011068">
        <property type="entry name" value="NuclTrfase_I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007012">
        <property type="entry name" value="PolA_pol_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048840">
        <property type="entry name" value="PolA_pol_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007010">
        <property type="entry name" value="PolA_pol_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014492">
        <property type="entry name" value="PolyA_polymerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682">
        <property type="entry name" value="POLY A POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682:SF10">
        <property type="entry name" value="POLYNUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04928">
        <property type="entry name" value="PAP_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20750">
        <property type="entry name" value="PAP_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04926">
        <property type="entry name" value="PAP_RNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018425">
        <property type="entry name" value="PolyA_polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55003">
        <property type="entry name" value="PAP/Archaeal CCA-adding enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) polymerase nucleotidyltransferase" evidence="17">
        <location>
            <begin position="7"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase central" evidence="16">
        <location>
            <begin position="212"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase RNA-binding" evidence="15">
        <location>
            <begin position="361"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="463"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="589"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="463"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="491"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="630"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="100"/>
            <end position="102"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="239"/>
            <end position="240"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR018425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR018425-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR018425-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF20750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK3302259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="646" mass="72726" checksum="88CDB824E631D7E6" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GLS0</accession>
    <name>A0AAJ0GLS0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Heavy metal tolerance protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0T15DRAFT_298110</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718027.1">
        <property type="nucleotide sequence ID" value="XM_062863785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GLS0"/>
    <dbReference type="GeneID" id="87882614"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000041">
        <property type="term" value="P:transition metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18583">
        <property type="entry name" value="ABC_6TM_HMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000186">
        <property type="entry name" value="ATP-binding cassette sub-family B member 7, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000050">
        <property type="entry name" value="Vacuolar ABC heavy metal transporter (Hmt1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF651">
        <property type="entry name" value="HEAVY METAL TOLERANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="461"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="487"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="577"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="345"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="664"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="57"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="277"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="944"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="280"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="948"/>
            <end position="984"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3302247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1032" mass="114408" checksum="9B9B0726C7C7A5A2" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GM19</accession>
    <name>A0AAJ0GM19_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_496924</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062867224.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87886053"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="50"/>
            <end position="70"/>
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    </feature>
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            <end position="114"/>
        </location>
    </feature>
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        <location>
            <begin position="139"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3302459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="257" mass="27580" checksum="4C6402D2A9DBE99E" modified="2024-07-24" version="1">MVTHAISPVPSLDLHPRDGTSHALISGAQAHSLESVFTNKAIFSDPFLELAQLTFAAFHFLITYLTLLVLSRPSIALFNPRRIHLLDILPLSLAMSLNMMLPNLSLAFSAVTLYQIAHTLLNPTVAALNAPPLPHNPAAGCNVWPSSRPASSTDDDDDHTPRDHPRPFSGTLASSLYTILGRRPPTAGLHASRHYQQLLFRQALPYPCPPPRGASLVGQQPLGAGAAELRTKGQGMVGVGVAVGEIVAYSVIMLQEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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        </recommendedName>
    </protein>
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    </gene>
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        <lineage>
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    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062865182.1"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="CidB/LrgB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30249:SF0">
        <property type="entry name" value="PLASTIDAL GLYCOLATE_GLYCERATE TRANSLOCATOR 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PUTATIVE SEROTONIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LrgB"/>
        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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            <end position="44"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="5">
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            <end position="159"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="5">
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            <end position="186"/>
        </location>
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            <end position="220"/>
        </location>
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            <end position="297"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="490"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="518" mass="55177" checksum="8F24F5ECD9C4171A" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ0GMM3_9PEZI</name>
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        <lineage>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
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                <person name="Cros-Aarteil S."/>
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
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                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="GeneID" id="87888853"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
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    </dbReference>
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        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42905:SF16">
        <property type="entry name" value="CARBOXYPHOSPHONOENOLPYRUVATE PHOSPHONOMUTASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_5G07230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42905">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13714">
        <property type="entry name" value="PEP_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3302759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="313" mass="33746" checksum="6EA48D747D795D1A" modified="2024-07-24" version="1">MSQRSLLYSSQTQNPRLICLSEPSKSPSSTPITILPFEVQTPPLPPTMTTPTLPTLAARAKAFKALHVPGTPLVLANVHDATSARIVASLPQCRALASASYALAKTIGIEDEQLTLDQNLRLLAPIAAVAHEFGLPFTVDIQDGYGDRLAETVRRVIVELGAVGVNLEDSHHEDGRMVGEEEAVERVKRALEVAREVGVPDFVVNARSDSFLVGGELDESIRRGKRYLEAGATTVFVFWPLDKDVREEDLKRVVDALEGRVNLNPRKASQVQSKALTSADLARLGAARVSVGPLLYRVAAQALTAAANEVFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GMS3</accession>
    <name>A0AAJ0GMS3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MHYT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_257838</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Sordariomycetes</taxon>
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            <taxon>Chaetomiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3302848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718628.1">
        <property type="nucleotide sequence ID" value="XM_062863273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GMS3"/>
    <dbReference type="GeneID" id="87882102"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005330">
        <property type="entry name" value="MHYT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35152">
        <property type="entry name" value="DOMAIN SIGNALLING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G11310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35152:SF1">
        <property type="entry name" value="DOMAIN SIGNALLING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G11310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03707">
        <property type="entry name" value="MHYT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50924">
        <property type="entry name" value="MHYT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="MHYT" evidence="3">
        <location>
            <begin position="22"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="706"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="833"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="416"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="711"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="835"/>
            <end position="853"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3302848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="942" mass="102337" checksum="3FA69D8E406D79D8" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GNA6</accession>
    <name>A0AAJ0GNA6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Beta-mannosidase B</fullName>
            <ecNumber evidence="3">3.2.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Mannanase B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0T15DRAFT_495691</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; N-glycan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the glycosyl hydrolase 2 family. Beta-mannosidase B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.25" evidence="3"/>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718897.1">
        <property type="nucleotide sequence ID" value="XM_062867120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GNA6"/>
    <dbReference type="GeneID" id="87885949"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004567">
        <property type="term" value="F:beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000118">
        <property type="entry name" value="Beta-mannosidase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000050">
        <property type="entry name" value="Beta-mannosidase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054593">
        <property type="entry name" value="Beta-mannosidase-like_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050887">
        <property type="entry name" value="Beta-mannosidase_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041447">
        <property type="entry name" value="Mannosidase_ig"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730:SF1">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22666">
        <property type="entry name" value="Glyco_hydro_2_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17786">
        <property type="entry name" value="Mannosidase_ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-mannosidase-like galactose-binding" evidence="12">
        <location>
            <begin position="13"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Mannosidase Ig/CBM-like" evidence="11">
        <location>
            <begin position="721"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3303117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="883" mass="99968" checksum="BFE39B7CDF7883DC" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GNE3</accession>
    <name>A0AAJ0GNE3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_576598</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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            <begin position="6"/>
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        </location>
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            <begin position="298"/>
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        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3303193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
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    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
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                <person name="Grigoriev I.V."/>
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                <person name="Hiltunen Thoren M."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
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                <person name="Cros-Aarteil S."/>
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
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                <person name="Ng V."/>
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                <person name="Steindorff A."/>
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                <person name="Martin F."/>
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                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062863425.1"/>
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    <dbReference type="GeneID" id="87882254"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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    </dbReference>
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        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Bud22/SRFB1"/>
    </dbReference>
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        <property type="entry name" value="Bud22_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23325">
        <property type="entry name" value="SERUM RESPONSE FACTOR-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23325:SF1">
        <property type="entry name" value="SERUM RESPONSE FACTOR-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
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            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Bud22" evidence="3">
        <location>
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        </location>
    </feature>
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        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF09073"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3303232.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
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                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
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                <person name="Hiltunen Thoren M."/>
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            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
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                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
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                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="nucleotide sequence ID" value="XM_062871041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GNX5"/>
    <dbReference type="GeneID" id="87889870"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3303396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="108" mass="12069" checksum="1CD6408A411B361B" modified="2024-07-24" version="1">MGPATVFCGGWLWTLGQPGLKRFKMIDSPWFEAAVDYVSALHTTWLALYILVLYYDRRSQFRILDGGGGKGSDHGAATEEPFANANCYLLAGRSRRAFWLVPSHTPIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GP03</accession>
    <name>A0AAJ0GP03_9PEZI</name>
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        <recommendedName>
            <fullName evidence="3">Arf-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_540484</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719313.1">
        <property type="nucleotide sequence ID" value="XM_062869790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GP03"/>
    <dbReference type="GeneID" id="87888619"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08839">
        <property type="entry name" value="ArfGap_SMAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000010">
        <property type="entry name" value="Stromal membrane-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051718">
        <property type="entry name" value="ARF_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044732">
        <property type="entry name" value="ArfGAP_SMAP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705:SF1">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="3">
        <location>
            <begin position="17"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="152"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="357"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="517"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="239"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="276"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="306"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="380"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="420"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="433"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="468"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="518"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3303533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="549" mass="56680" checksum="97A3617E4DAB5DB8" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GP40</accession>
    <name>A0AAJ0GP40_9PEZI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_279014</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719333.1">
        <property type="nucleotide sequence ID" value="XM_062863552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GP40"/>
    <dbReference type="GeneID" id="87882381"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3303553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="233" mass="25504" checksum="15C00E73E186E2B9" modified="2024-07-24" version="1">MVAFASRQAFCREQSCTNHRGLRRLTDFYSRIVALDIGLLPPDSNFTTTRQPVYSFDCHLADGRVGAGESLRSLTTSPFPQYHRCQHSVGFPVAWVPRPIVDLWRLPRCIPFCRGLYHNPNLQRTDPSVPGLATLHLGFRASATGPKTLLNSQVAMAQCAGCGTIGHVNLQVSGITSHSACSIDKVGSDIGGLACRSHVSEQSYGDTSAYRIIGACHHELSQAVRVFRSPRHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GP75</accession>
    <name>A0AAJ0GP75_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_486922</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="2"/>
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        <property type="protein sequence ID" value="KAK3303546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062866394.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87885223"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="probable E3 ubiquitin-protein ligase HERC4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.130.10">
        <property type="entry name" value="Ubiquitin-protein ligase E3A, N-terminal zinc-binding domain (AZUL)"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="AZUL"/>
    </dbReference>
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        <property type="entry name" value="AZUL_sf"/>
    </dbReference>
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        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
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        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF8">
        <property type="entry name" value="HECT-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16558">
        <property type="entry name" value="AZUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="7">
        <location>
            <begin position="955"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="157"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="274"/>
            <end position="416"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="428"/>
            <end position="493"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="527"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1138"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="191"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
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            <end position="488"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
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            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1138"/>
            <end position="1151"/>
        </location>
    </feature>
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        <location>
            <position position="1298"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
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        <source>
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        </source>
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        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3303546.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1330" mass="148216" checksum="0CAF061B0548CA5C" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ0GPI7_9PEZI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="1 2">
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        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3303764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="272" mass="31473" checksum="51B61871322F5A3E" modified="2024-07-24" version="1">MEFEDISYSRETTIAAVADFYTFLTKMYLDESQVAYPPAGGWPEIVNADPAVLRSFGKSDEVLALLARLPYIQYPSGLWDHAAEPTPGHVFINWPDLLSIRDPNDEDPGRTLRLYTEGDFYDIYPPHRASYVFLLDTKLGIIHWGNCSTRIENGEWTVNMIDKIDVEEEAQERSEEEADWRSSAPAWAIQDFFEVLKDQFRKLHWVPISHYSVRNVAEGEYHGEDGMMAMLLDIYRRHGWPDLTVYRKEDCIVNVLKAMKEKYPGSTCYREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ0GPT0_9PEZI</name>
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        <recommendedName>
            <fullName evidence="3">Transferase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719465.1">
        <property type="nucleotide sequence ID" value="XM_062869822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GPT0"/>
    <dbReference type="GeneID" id="87888651"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3303685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="473" mass="53335" checksum="57B4357E9B3B47E4" modified="2024-07-24" version="1">MEVIPISALDNVGAFRNTRVRTFFLLDDRLDEVKLRDALTGLIRDHWRKLGARIVMGKNKRRPVYHVPKVFDDNYELFRWSVDHSASPIDEAAPELQLKTAKPEGGVAVLPSVEVFDARFRPQHWPISLDAEPDAPLLLVHLSLFADATVISTSHPHILGDQLGLANILKAWLGLLEHKAPPPMVGYNEDILPGQKPFAEYPKSETFKKGRHRVRGPFERLFILPGYIWEMILEPKEEKATVFFPLPVLQSLRERYTAGLSEKDGASAELTNGDIISAIMTKLVRLYSNKKPTLSLTQTINLRGRIPALSTPQAQAGYLHNGLIYATSRFRYDPAMPASEIARLNRAAVADVLGDEDTIDVLCAVSREQHRRDQPLHICEPWERSYHITNWAPAWRDLDFGPALAEDAREARQGRRVGLVVHGDGQVPGVPARYVSFITSKSEDGYWVSFGTTIRGMEAVRKYLAEDPMLERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQ23</accession>
    <name>A0AAJ0GQ23_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ankyrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_577077</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719600.1">
        <property type="nucleotide sequence ID" value="XM_062871053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQ23"/>
    <dbReference type="GeneID" id="87889882"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3303820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="479" mass="53819" checksum="B497EFD99A151B80" modified="2024-07-24" version="1">MAKQLGMEAALALRVLEADGDGLARKDKARDLISLAMQQLEESSQLANKIRTAAPKWTRGHEKTTKYREAIGWECIGYRRLSLCYAALGSIDANPRTRERMFHKAAKLSGKAARVGSCMSATGSSVLPMCQFFRGHVFLMQESRPGNIGSLREVIDVGADLDVADPEGSTALDHAVLSGDAETKETVLKGLRRQLALSEDDLADRRTEARLRKAHREILQEKLRPVLYEHSKDADCIKDLRRAYAETLAADPEKRALFDHLKFMRYTDFKWFGRLPHSSDGLAQAFVSEHLGGSKDDTNSDALIFFSYRWINQDPDRNTPDGAINTQYRRMIDAAELFLEQNPSVRAERLGVWMDFACVDQDNPATGVSALPIVTLCDAVFSLVDDMYYERAGCCVEAKMISELTPERRFPAPFFYQVQTVHRWYEHIPAPEPSGHGGQKWILQPARRGGLPLRNKKLTFERDRPKTVLKNLKSLCGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQE3</accession>
    <name>A0AAJ0GQE3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SPX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_485926</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719992.1">
        <property type="nucleotide sequence ID" value="XM_062866323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQE3"/>
    <dbReference type="GeneID" id="87885152"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006797">
        <property type="term" value="P:polyphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01115">
        <property type="entry name" value="SLC13_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14478">
        <property type="entry name" value="SPX_PHO87_PHO90_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001898">
        <property type="entry name" value="SLC13A/DASS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283:SF92">
        <property type="entry name" value="LOW-AFFINITY PHOSPHATE TRANSPORTER PHO91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00939">
        <property type="entry name" value="Na_sulph_symp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="475"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="509"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="562"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="609"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="652"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="691"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="734"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="759"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="787"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="827"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="872"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="915"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="7">
        <location>
            <begin position="113"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="17"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="209"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="241"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="260"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3304212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="943" mass="103832" checksum="9685661CFE10E423" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQR0</accession>
    <name>A0AAJ0GQR0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_503477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
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    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
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                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
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                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
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                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
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            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="entry name" value="Cwc2/Slt11"/>
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        <property type="entry name" value="Nrd1_Seb1_dom2"/>
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    <dbReference type="PANTHER" id="PTHR14089:SF2">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="758" mass="79555" checksum="3559963D4ABCCF2A" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GRB4</accession>
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        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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    <organism evidence="10 11">
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    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
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                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
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                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
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                <person name="Hiltunen Thoren M."/>
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            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="1">CBS 333.67</strain>
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        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="1">CBS 333.67</strain>
        </source>
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    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
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<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720682.1">
        <property type="nucleotide sequence ID" value="XM_062869657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GRS6"/>
    <dbReference type="GeneID" id="87888486"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039323">
        <property type="entry name" value="ANKRD_45/46/60"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22677">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22677:SF4">
        <property type="entry name" value="USHER SYNDROME TYPE-1G PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="24"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3304902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="83" mass="9120" checksum="65D1A531D5E44598" modified="2024-07-24" version="1">MYGLASMVSELLAHGAEIDAEDRHGLTPLLVAVQRGNLEAVQTFVSRGAKTDITDDQGHSLLDIARILGHTNTYLWLERQMTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GRU5</accession>
    <name>A0AAJ0GRU5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mannan endo-1,4-beta-mannosidase A</fullName>
            <ecNumber evidence="4">3.2.1.78</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Endo-beta-1,4-mannanase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0T15DRAFT_256369</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random hydrolysis of (1-&gt;4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans.</text>
            <dbReference type="EC" id="3.2.1.78"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.78" evidence="4"/>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720741.1">
        <property type="nucleotide sequence ID" value="XM_062863258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GRU5"/>
    <dbReference type="GeneID" id="87882087"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016985">
        <property type="term" value="F:mannan endo-1,4-beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046355">
        <property type="term" value="P:mannan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000076">
        <property type="entry name" value="Mannan endo-1,4-beta-mannosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045053">
        <property type="entry name" value="MAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451:SF21">
        <property type="entry name" value="MANNAN ENDO-1,4-BETA-MANNOSIDASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26410">
        <property type="entry name" value="GH5_mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042469200" description="Mannan endo-1,4-beta-mannosidase A" evidence="11">
        <location>
            <begin position="21"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="12">
        <location>
            <begin position="31"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00077212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF26410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3304961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="419" mass="46951" checksum="B078687380383DBA" modified="2024-07-24" version="1">MHASSLHLLVSGLLALTATAAPSKPGRPSSKFVSVEGDKFKLQGKDFHFAGSNAYYFPFNGVRGLLNQQDIEKGLTAAKKAGLTVFRTWGFNDKNSTFVPGGLPQYGGEGAGPSEVVFQWWHANGTSTIDVSGFDKVVQAATKVGGIKLVVALTNNWADYGGMDVYTVNLRGQYHDDFYTVPRIKDAFKRYVREMVTRFRDSPAIMAWELANEPRCGADGVRNLPRSPGDRCTPAVVSSWIAEMSGYIKTLDRNHLVTWGGEGGFNRPSEDDWAYNGADGGDFDHELSLDTIDFGVFHSYPDWWSKTVEWTDQWIRDHAAAGRRAGKPVVHEEYGWLTPDKRLEYTGKVDNRTRGEVVGAWQQTMVAEKMAGDMYWQYGFSNYSYGRNHDDGFTIYLDDEEAKTLVYRHARDMNALNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GS51</accession>
    <name>A0AAJ0GS51_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_486360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720670.1">
        <property type="nucleotide sequence ID" value="XM_062866351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GS51"/>
    <dbReference type="GeneID" id="87885180"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052431">
        <property type="entry name" value="SKI2_subfamily_helicases"/>
    </dbReference>
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        <property type="entry name" value="DEAD/H RNA HELICASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44533:SF4">
        <property type="entry name" value="DEAD_H RNA HELICASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3304890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="236" mass="26778" checksum="75010B21F397D1EB" modified="2024-07-24" version="1">MKAVTLLPPDTTARGYQPEHCGPYLERSFDSAPDPSFHPDAWQRKAGKIFVSFYAMKKVLQATTTTSWSTWFRLLKHWSIRSRPKSSCASPRKYAQEGKFVWAIHTRDYRIHNVKGYQILVTVPQMLLQILTPRAGQCQGTAQLLAGAFKRIVFNEHVVWEQLLLLGLCPIIATRSQKVKGFVFEMIVHSSRSSDGRTCGSFIYNPVPSVLEFTGLAPVERLPFPGLDSELRTEKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GSW2</accession>
    <name>A0AAJ0GSW2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0T15DRAFT_396509</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721309.1">
        <property type="nucleotide sequence ID" value="XM_062864841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GSW2"/>
    <dbReference type="GeneID" id="87883670"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Heat shock transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000212">
        <property type="entry name" value="Stress response regulator/HFS transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014402">
        <property type="entry name" value="Sig_transdc_resp-reg_Skn7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002595">
        <property type="entry name" value="RR_SKN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00434">
        <property type="entry name" value="HSF_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="12">
        <location>
            <begin position="335"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="175"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="458"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="510"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="585"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="519"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="542"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="615"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="9">
        <location>
            <position position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR002595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3305529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="624" mass="68150" checksum="0B38E1AC4D6962F3" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GT17</accession>
    <name>A0AAJ0GT17_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_493768</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721398.1">
        <property type="nucleotide sequence ID" value="XM_062866969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GT17"/>
    <dbReference type="GeneID" id="87885798"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3305618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="82" mass="9183" checksum="18C06B6556DE3923" modified="2024-07-24" version="1">MPIICKVCHICNDTVKSALDKIKVPYTESKSGSTTIYRVNTSSPSKWSRGSLARMCWDKLQLGPYHEARKNGDTIHCSNVQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GT43</accession>
    <name>A0AAJ0GT43_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_396096</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721220.1">
        <property type="nucleotide sequence ID" value="XM_062864813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GT43"/>
    <dbReference type="GeneID" id="87883642"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006846">
        <property type="entry name" value="Ribosomal_eS30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12650">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S30/UBIQUITIN-LIKE PROTEIN FUBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12650:SF15">
        <property type="entry name" value="RIBOSOMAL PROTEIN S30, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04758">
        <property type="entry name" value="Ribosomal_S30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3305440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="63" mass="6813" checksum="B55B21FA1FB35B03" modified="2024-07-24" version="1" fragment="single">VGKVHGSLARAGKVKSQTPKVEGQEKPKTPKGRAHKRELYSRRFVNVAVTGGKRKIGKDAVCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GTA8</accession>
    <name>A0AAJ0GTA8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HAD-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_556193</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily. S-2-haloalkanoic acid dehalogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721532.1">
        <property type="nucleotide sequence ID" value="XM_062870410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GTA8"/>
    <dbReference type="GeneID" id="87889239"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019120">
        <property type="term" value="F:hydrolase activity, acting on acid halide bonds, in C-halide compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006328">
        <property type="entry name" value="2-HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051540">
        <property type="entry name" value="S-2-haloacid_dehalogenase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01493">
        <property type="entry name" value="HAD-SF-IA-v2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01428">
        <property type="entry name" value="HAD_type_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316:SF3">
        <property type="entry name" value="HALOACID DEHALOGENASE, TYPE II (AFU_ORTHOLOGUE AFUA_2G07750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316">
        <property type="entry name" value="HYDROLASE, HALOACID DELAHOGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3305752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="245" mass="26606" checksum="EFF4CA0B2677C8DD" modified="2024-07-24" version="1">MSTAQTIIAFDLYGTLLSTDSVTGELAKLVDDGAAKELSTLWRRYQLEYTWRINSMGHYCSFSDITRASLLHAAAEMKLSLTSDDVGRAMEAYDALRVFPDVPPALEALSGLDSSEAEAYIFSNGTGEVLKASVYNSPDLKPYASAFRKVVSVEDVEVFKPDRKAYDHLLKGVGRVGAPGDVWLVSSNPFDALGAVAAGLKSCWIDRARTGWIDRLGSVIGENMRPTLVASSVGEAVQMILKRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GTB9</accession>
    <name>A0AAJ0GTB9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_434538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721340.1">
        <property type="nucleotide sequence ID" value="XM_062865799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GTB9"/>
    <dbReference type="GeneID" id="87884628"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18724">
        <property type="entry name" value="PIN_LabA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007681">
        <property type="entry name" value="Mog1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15837:SF5">
        <property type="entry name" value="NYN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15837">
        <property type="entry name" value="RAN GUANINE NUCLEOTIDE RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="579"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="308"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="602"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3305560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="725" mass="80252" checksum="8F67F1DB1A735031" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GTF2</accession>
    <name>A0AAJ0GTF2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP-dependent RNA helicase DHH1</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">ATP-dependent RNA helicase dhh1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">B0T15DRAFT_396057</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721400.1">
        <property type="nucleotide sequence ID" value="XM_062864810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GTF2"/>
    <dbReference type="GeneID" id="87883639"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17940">
        <property type="entry name" value="DEADc_DDX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000114">
        <property type="entry name" value="ATP-dependent RNA helicase DDX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000364">
        <property type="entry name" value="ATP-dependent RNA helicase DDX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47960">
        <property type="entry name" value="DEAD-BOX ATP-DEPENDENT RNA HELICASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 17 22" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="5 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="21">
        <location>
            <begin position="47"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="19">
        <location>
            <begin position="78"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="20">
        <location>
            <begin position="258"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="438"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="16">
        <location>
            <begin position="47"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="440"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="468"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="483"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="496"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="532"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="544"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
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            <dbReference type="PROSITE" id="PS51194"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3305620.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
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</entry>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </evidence>
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    </evidence>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
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                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
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                <person name="Ohm R.A."/>
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                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
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                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
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                <person name="Hiltunen Thoren M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="87889250"/>
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    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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    </evidence>
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    </evidence>
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            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="161" mass="17581" checksum="B9249F7BFEC583C6" modified="2024-07-24" version="1">MAGSFIWTALQVAPLASSSAAVICSICQQVTMTSFLGATVPAQARKEVYYPFHEGFKRMVLVSAPAHLTTIATCLINFFAGNPSSLWWLACVAFVVGHAYPLAEGMKILGLTAREWNSKTLPESRAFIQGFVDINQRRLLLVDFPGWLCVLATVLVNLRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
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                <person name="Lalanne C."/>
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                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722193.1">
        <property type="nucleotide sequence ID" value="XM_062864785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GUK9"/>
    <dbReference type="GeneID" id="87883614"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097:SF8">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097">
        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3306413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="28946" checksum="3E57C4BE483545CA" modified="2024-07-24" version="1">MHLILTGATGLVGTAVLDAMLKTKDISKISVLSRRPVKFQDDRINVIIHQDFASYERDILDKLEGAQSCVWALGISQTQVSKEEYIDITKAYPLAAAKAFQSLPPQTETKQPFHFVYVSGDGATFTPGRFTPFFGRIKGETELALAEMQKANPSSFRASTVRPGVVDWTGHAEVKPFLPDIGLFRSVAGVVMSHITKRVAPSKWSPTEPLGRFLTGMAMGMWDGALEGEGVQRLPSGFTVVDNNGIRRLIAGGLDEVTRHGRDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GUN6</accession>
    <name>A0AAJ0GUN6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7082 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_136819</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722075.1">
        <property type="nucleotide sequence ID" value="XM_062861824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GUN6"/>
    <dbReference type="GeneID" id="87880653"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055509">
        <property type="entry name" value="DUF7082"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39463">
        <property type="entry name" value="MEDUSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39463:SF1">
        <property type="entry name" value="MEDUSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23305">
        <property type="entry name" value="DUF7082"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7082" evidence="2">
        <location>
            <begin position="435"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="626"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="753"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="627"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="644"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3306295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="777" mass="81926" checksum="72DB1077B1B6FD07" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GUN8</accession>
    <name>A0AAJ0GUN8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="9">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_491952</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Esterase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the carbohydrate esterase 1 (CE1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="9"/>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722182.1">
        <property type="nucleotide sequence ID" value="XM_062866820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GUN8"/>
    <dbReference type="GeneID" id="87885649"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010126">
        <property type="entry name" value="Esterase_phb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050955">
        <property type="entry name" value="Plant_Biomass_Hydrol_Est"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01840">
        <property type="entry name" value="esterase_phb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43037:SF3">
        <property type="entry name" value="FERULOYL ESTERASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43037">
        <property type="entry name" value="UNNAMED PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10503">
        <property type="entry name" value="Esterase_PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0964">Secreted</keyword>
    <keyword evidence="2 9" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042316669" description="Carboxylic ester hydrolase" evidence="9">
        <location>
            <begin position="23"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3306402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="314" mass="33719" checksum="204B88035B5A40E2" modified="2024-07-24" version="1">MKLLSCLSAVLALMGSTGSIVAAHPVFDQLMEPSSPLRRAQAALTRVNDFGPNSSNTKMYIYVPNKLAAKPPVIVAIHYCTGTAQAYYSGSPYAQLADQKGFIVIYPESPYSGTCWDVSSRSALTHNGGGDSNSIANMVTYTLNKYNGDASKVFVTGSSSGAMMTNVMAATYPELFAAGIVYSGTAAGCFYSQSGGVNQWNNSCANGQARGTPEVWAKMVFDMYPGYGGARPKMQIYHGSADTTLYAANYNETIKQWCGVFGYDYTRPDATLPNTPQARYTTYTWGDKLVGVYAQGVGHSVPIRGSDDMKFFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GUP6</accession>
    <name>A0AAJ0GUP6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine phosphatase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_137192</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722090.1">
        <property type="nucleotide sequence ID" value="XM_062861830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GUP6"/>
    <dbReference type="GeneID" id="87880659"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF142">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="433"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3306310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="487" mass="51668" checksum="650886680B15CE92" modified="2024-07-24" version="1">MHAPVSAFALGGALFAASGAAHIVHGVLVFSRHGDRTAKHFGNASLTSLGAQQVFQVGSDYRARYLSSASSSRISKISEFEYVPAQVWASAPDEPILLGTATAFLQGLYPPLGDVQPTLTATGLANGSSVSGPLSGYQYVTLHGVDDESPETVWIKGDDNCPAVKAASASFNLSAEYQAREAATRDFYRGLYPLLSDYYASADDLSYTKAFDIFDLVNVERIHNASSPARNISDADFLQLRTLADSAEFGANFNASQPARSIHARTFAAAVVRHLNQTLSSTATKQQPKFTLLTGSYDTFLAFFGLAGLTSVSDDFYGLPDYASTMAFELFSPTDDSAGLQVGQPYVRYLFRNGTQGELQAYPLFGTDKEEMPWTEFAGAVSQRGAIGDVGTWCGECRSEAVFCAAYTNNGAGDGAATAVDLDGGSSVGRGSWIAVLVVMAVAIAGNLVWAGMWLVQRQRKTAVAAAAAADKGYDDSVRSYGGKESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GUQ0</accession>
    <name>A0AAJ0GUQ0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">U3 small nucleolar RNA-associated protein 6-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_220472</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UTP6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3306195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721975.1">
        <property type="nucleotide sequence ID" value="XM_062862806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GUQ0"/>
    <dbReference type="GeneID" id="87881635"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013949">
        <property type="entry name" value="Utp6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055347">
        <property type="entry name" value="UTP6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23271">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23271:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08640">
        <property type="entry name" value="U3_assoc_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 6 N-terminal" evidence="7">
        <location>
            <begin position="12"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="225"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="227"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="253"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3306195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="411" mass="45925" checksum="F706BC85DEBCC70A" modified="2024-07-24" version="1">MAGVSDKARFYLERAAPELREFEEKGIFSKDEIRTLVTKRSDFEHLILSPGTKPSDFLSYVSWERSLDRLRAKRCRKLNLSRSSSSHASQARTFGIFERAVLKHPGCVPLWLAYLDFAAQAKATKRWRRIATRALRLHPTNAQLWTIAGRRAAQGGDMERARAHFLRGCRFCTGDAALWVEYARCEMEWLAKVEAKKAGKGVRKGVNALEAIKATEAVQEGDIIRFDEEDEESGDEGELMLPDPDAQGQGTKKKPDVFDEETTRKMEQSPALSGAIPMAIFDIARKQPFFGPAAAEQFFDVFAGFSNLSSQERIVQHVLAAMEELFPNHPCTCSCQIRQPLIGVSIVTAAFPKALRESLARLKVALEGTTDRKALARKTVVWVDAILATEGLDEAIKTVLEHTKRSLESPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GV01</accession>
    <name>A0AAJ0GV01_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_144664</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722334.1">
        <property type="nucleotide sequence ID" value="XM_062861920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GV01"/>
    <dbReference type="GeneID" id="87880749"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1070">
        <property type="entry name" value="Translation initiation factor eIF-2B, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051501">
        <property type="entry name" value="eIF2B_alpha/beta/delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042528">
        <property type="entry name" value="elF-2B_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45860">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45860:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="23"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3306554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="388" mass="42141" checksum="D17FAB8BB69584BA" modified="2024-07-24" version="1">MLRCRLLPPFRASVFFASTMSADGPSSSAARGEPQGFPWQDKPSRPSPSPEKNTSGAFDVVQTYRELLNSDRELTMGVAAIESLIEVLRATPSSTAMETVEVVKKEKAKLLASTPNPLPLLAGADLFEQYLLRSLRGPTAEGVTGSASDRVLSFEETRQHLLNNKQLFAQRAKAARDSIAIWGSRYVSDGRIVLTAGGSRTVTKILLRAAADPSKHFKVIYVVDGRNKRSDVAVAQLREAGLEVETISPHKVAYVLGNQKLINLVLVGTEVVMQNGGIISGMGTAQLAHLTKTVKGGIKRFYVAAETHKICRKTPIAYPMVNRVGVNQKDISKFDNVGVDVGLDPETAGMLAEQDEVDYTDPELIDGIITEQGVKMASAIWEMVDVYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GVA6</accession>
    <name>A0AAJ0GVA6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_492338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722597.1">
        <property type="nucleotide sequence ID" value="XM_062866855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GVA6"/>
    <dbReference type="GeneID" id="87885684"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3306817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="156" mass="15865" checksum="A2F36AB588C891D8" modified="2024-07-24" version="1">MNIYWCFGNIPAKEPIPKPQLLPLPPGYYRGGGSGSSGSSGGGAGAGAGGSGYHPGYASGPVQPTSYGSNPFTSDAIAGLDLAYARKGIAYNAAKRRKTPVPLNRTSSSKPSTKADPPGSRNARPPNTNPASSLSDSLRRLSLKDKGHKGAGAPVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GVN2</accession>
    <name>A0AAJ0GVN2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Lon protease homolog 2, peroxisomal</fullName>
            <ecNumber evidence="8">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0T15DRAFT_160950</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the peptidase S16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="8"/>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722783.1">
        <property type="nucleotide sequence ID" value="XM_062862106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GVN2"/>
    <dbReference type="GeneID" id="87880935"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd19500">
        <property type="entry name" value="RecA-like_Lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.5270:FF:000002">
        <property type="entry name" value="Lon protease homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000091">
        <property type="entry name" value="Lon protease homolog 2, peroxisomal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000039">
        <property type="entry name" value="Lon protease homolog 2, peroxisomal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.5270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="entry name" value="LON domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03121">
        <property type="entry name" value="lonp2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004815">
        <property type="entry name" value="Lon_bac/euk-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054594">
        <property type="entry name" value="Lon_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027501">
        <property type="entry name" value="Lonp2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00763">
        <property type="entry name" value="lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="ATP DEPENDENT LON PROTEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22667">
        <property type="entry name" value="Lon_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00830">
        <property type="entry name" value="ENDOLAPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="2 8 9" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="12">
        <location>
            <begin position="9"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="11">
        <location>
            <begin position="748"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="293"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="452"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Microbody targeting signal" evidence="8">
        <location>
            <begin position="966"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="324"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="453"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="active site" evidence="8 9">
        <location>
            <position position="841"/>
        </location>
    </feature>
    <feature type="active site" evidence="8 9">
        <location>
            <position position="884"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="505"/>
            <end position="512"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3307003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="968" mass="105417" checksum="B442F76895063521" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GVV8</accession>
    <name>A0AAJ0GVV8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NOT2/NOT3/NOT5 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_529035</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722824.1">
        <property type="nucleotide sequence ID" value="XM_062869072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GVV8"/>
    <dbReference type="GeneID" id="87887901"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="5">
        <location>
            <begin position="360"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="83"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="235"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="136"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="259"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3307044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="491" mass="52648" checksum="6CAF2FC1CE0C8D45" modified="2024-07-24" version="1">MMNRPGAVPQSLRGVPGGGFGGQQQQQQQQQQSGRALANRLPNGKIGPIGNGPGWFGGMPMGGSASVPPGAARQIGGNVSFAQSLTGSQPATPLDLSEFPSLSNTSQLTSTAQTSMWSAQGPRNLGGGIHRGAGTPLSSQQTQQDDLFASRLSTGQGSFRFGNQGNTAQASQSLSSVTDEFPPLNRAANGEIGGQDRGGNLMSNLGFGAPGSAAGSAMHASRAGNGLLSALSATSRTADVRSPTAIGRPQDLRSPVGEDEPRQKPAGYREEPADGVGGRNPLGAIGNDAPTGKGKDEEKPPTNQVQDPLEGMALIDKWGLKGLRTLMNNFPDYNALTCGIDPSLLGVDMRSTDTLSTKVYSLFDDVPPRSPVPKFRLPDCYHVKNVQPIEAKISSFNEETLMWIFYSCPRDIKQQMAAIELNNRNWRWHKKYQFWLTKDDIMAPQNLGPGHERGYYIVWDTVNWRKERRELMLQYADLDTTPTAQLQSLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GW74</accession>
    <name>A0AAJ0GW74_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Monooxygenase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_166035</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722915.1">
        <property type="nucleotide sequence ID" value="XM_062862162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GW74"/>
    <dbReference type="GeneID" id="87880991"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="442"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="477"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3307135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="518" mass="59018" checksum="ABB55DFAC406DADF" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GW97</accession>
    <name>A0AAJ0GW97_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_529530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722960.1">
        <property type="nucleotide sequence ID" value="XM_062869111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GW97"/>
    <dbReference type="GeneID" id="87887940"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="37"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3307180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="319" mass="35323" checksum="C91A4A5098B3AB9C" modified="2024-07-24" version="1">MASSTLPSNCRLVNIGTHSLALYTHGPEPTSPTDPVVLFISGIASDALNWQAVVRLLGPTQLRSYTYDRSGYRNSECSPLPPSAETIALELSLLISHAPIANPLILVGHSWAGVLIHEYMALRKGTKQIAGVVLVDANHETAPLVLDVNDPVLWGVMASGVEPYAAWGVEAEHKLTREEWDAFKAAEATEKYRVVASQEEEHYLPSFEALRRKELRKRQPLLGDRPVYVIAGKRSRDWSGLYKAGVARGNGTEEQRRYVRGLIERVDVKTEGLMREFLKLSTKSELVFASRSGHFVQLTEPELVVDGVRWVVDNLSVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GWP4</accession>
    <name>A0AAJ0GWP4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_492974</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723274.1">
        <property type="nucleotide sequence ID" value="XM_062866901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GWP4"/>
    <dbReference type="GeneID" id="87885730"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000180">
        <property type="entry name" value="MFS monosaccharide transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF61">
        <property type="entry name" value="HIGH AFFINITY GLUCOSE TRANSPORTER RGT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="371"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="406"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="473"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="29"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3307494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="546" mass="59614" checksum="143258054839E28C" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GWQ7</accession>
    <name>A0AAJ0GWQ7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Oxidase ustYa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0T15DRAFT_393549</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723336.1">
        <property type="nucleotide sequence ID" value="XM_062864689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GWQ7"/>
    <dbReference type="GeneID" id="87883518"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF11">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0843">Virulence</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3307556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="255" mass="28969" checksum="392DF18C52B9EF8D" modified="2024-07-24" version="1">MDSEKHAADEEQEAFLSHPQRGGNATTDIPPDGRHHGEKSDRATKLMKWLRLLLEIAMAVTIVCLLVFKPSVAGRETLRRTPVPHFPKKIYTFRNDPKYVRGDMWFNESLTLRTLHNWIELSSDSRGYVVIDDPSGYDLPEPYTVALDRHNDGPGYMMTVFHQLHCLSYLAEHYQQGYDGVKLTEEVAHHTAHCFNYLRQGIMCSADTTLEGKTEAGPGEGSEHECTDYDALLEWANKHSAMKWRNGLLPGESIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GWS7</accession>
    <name>A0AAJ0GWS7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_567011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062870712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GWS7"/>
    <dbReference type="GeneID" id="87889541"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
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        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF93">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PLK1"/>
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    </dbReference>
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        <property type="entry name" value="Pkinase"/>
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        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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        <property type="entry name" value="PROTEIN_KINASE_ST"/>
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    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3307582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="239" mass="26986" checksum="34E993DA1873D244" modified="2024-07-24" version="1">MSHNEPWPPVPPDIDTTKLEVEMPELVVSANSTLFRVKGQPSTVYKFRGLPHEYQLQKARGGDCAIPVRGRVLGKSTVGAGDVTLSLPQRRDIMDQMIRTVQQLHAKRIVHEDIKLENMLLDSCGKLRLCDFAEGRYLDEDECLGGQVHWHFESPNRLRRGERLGYGLPPPIIEDDLYGLGLSIWQLYTGRTPHEDMVCDDLGLKERQRNGETVNVAEVGDPEARDIIVELLRRGGARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GWW8</accession>
    <name>A0AAJ0GWW8_9PEZI</name>
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        <submittedName>
            <fullName evidence="4">Ribonuclease/ribotoxin</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">B0T15DRAFT_493112</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723426.1">
        <property type="nucleotide sequence ID" value="XM_062866919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GWW8"/>
    <dbReference type="GeneID" id="87885748"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.30">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000026">
        <property type="entry name" value="N1-like"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease/ribotoxin"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53933">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042513013" evidence="3">
        <location>
            <begin position="18"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3307646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="167" mass="18370" checksum="5480E2C03068877A" modified="2024-07-24" version="1">MKSYSIIVSLMAALAVGAPLEATNSNATVSNSNGTDTKIVPQAFTRFRCRNSEGAITFDKNRVFANVQNFPDRETPGLSGYPHEFSNFQGFAWDFNQWQCGNYEPLLEMPVFPDGHLYKWNVNRNAAGGESPGPARAIYTATGVIQFCGLIAHTSGNQGYFDKCEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GX60</accession>
    <name>A0AAJ0GX60_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_530366</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723265.1">
        <property type="nucleotide sequence ID" value="XM_062869165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GX60"/>
    <dbReference type="GeneID" id="87887994"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40130">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40130:SF1">
        <property type="entry name" value="SPINDLE POLE BODY-ASSOCIATED PROTEIN CUT12 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="86"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="160"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="261"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="335"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="525"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="479"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="160"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="214"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="352"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="534"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3307485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="545" mass="59632" checksum="8905FF402854C364" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GYI5</accession>
    <name>A0AAJ0GYI5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Copper acquisition factor BIM1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0T15DRAFT_109637</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724306.1">
        <property type="nucleotide sequence ID" value="XM_062861484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GYI5"/>
    <dbReference type="GeneID" id="87880313"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21176">
        <property type="entry name" value="LPMO_auxiliary-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046936">
        <property type="entry name" value="BIM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046530">
        <property type="entry name" value="BIM1-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34992:SF5">
        <property type="entry name" value="ANCHORED PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G02800)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34992">
        <property type="entry name" value="HYPHAL ANASTAMOSIS-7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20238">
        <property type="entry name" value="BIM1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042498243" description="Copper acquisition factor BIM1-like domain-containing protein" evidence="10">
        <location>
            <begin position="28"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Copper acquisition factor BIM1-like" evidence="11">
        <location>
            <begin position="32"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="182"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="274"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="278"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3308526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="301" mass="31154" checksum="A7CA4DC5BCB07484" modified="2024-07-24" version="1">MGSAHCMLKMVVLQSILLLAAAAGVQGASDDMGPAAIMWPPDRAWSAQVDNTAPCGSVASVTNRTGFPLTGGKLAFVAQDDSYNTEISISFNNDPKSQSDFTTLRTSAIPELDPGHTCISIPNPPATIGAGANATIQIKYTADFDRPENQTFYACADITYVAAASFNQADVPCFNATEDVDVPAPTTTGTPTNLPGHGDEGPPLVEPGSEATATATVIADAGPKGLSKGGIAGAVVGSVVGVALIVGLGLLFYRERERKKRLVRQRDSAIRVGKTVDGASTRTGNDSVSGESIRMGNLSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GYJ0</accession>
    <name>A0AAJ0GYJ0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_491051</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724249.1">
        <property type="nucleotide sequence ID" value="XM_062866744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GYJ0"/>
    <dbReference type="GeneID" id="87885573"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3308469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="244" mass="27445" checksum="E33D45826C8FB97F" modified="2024-07-24" version="1">MQSSTSKDDWTAAYILVLLIPIGFVAAAVFWCFSARRRRQLDARRNQHRDVEVAVSAAAATRDTPLRFLPREAAAHRGPKPSSPPHPTIPSRALLSNSVSKRNQHHLLATHHHKAAHRLPNTNLLTAPDPALASRRKHGSRRHYCSGREEEEKKEQRRNNQPSTTPPQPSSSSPSDSLGDVSSPALRHRHDVPDCDPRRRREHHKKVAALRRMTEVLEEASEEGSVSSGGWGRRNDTREVRQNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GYM2</accession>
    <name>A0AAJ0GYM2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_111277</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNR ribonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724353.1">
        <property type="nucleotide sequence ID" value="XM_062861506.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87880335"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.690:FF:000001">
        <property type="entry name" value="Cell wall biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.700:FF:000002">
        <property type="entry name" value="Cell wall biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000100">
        <property type="entry name" value="Cell wall biogenesis protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041505">
        <property type="entry name" value="Dis3_CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041093">
        <property type="entry name" value="Dis3l2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF9">
        <property type="entry name" value="DIS3-LIKE EXONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17877">
        <property type="entry name" value="Dis3l2_C_term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17849">
        <property type="entry name" value="OB_Dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNB" evidence="3">
        <location>
            <begin position="739"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="119"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="492"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="597"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1206"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1263"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="166"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="265"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="284"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="301"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="506"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="518"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="532"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="602"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1209"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1236"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1269"/>
            <end position="1279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3308573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1361" mass="149427" checksum="49CB0CA8363F3323" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GZ87</accession>
    <name>A0AAJ0GZ87_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleophile aminohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_565898</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724644.1">
        <property type="nucleotide sequence ID" value="XM_062870678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GZ87"/>
    <dbReference type="GeneID" id="87889507"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061672">
        <property type="term" value="C:glutathione hydrolase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008242">
        <property type="term" value="F:omega peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01908">
        <property type="entry name" value="YafJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000045">
        <property type="entry name" value="Glutamine amidotransferase DUG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026869">
        <property type="entry name" value="EgtC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052373">
        <property type="entry name" value="Gamma-glu_amide_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43187">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE DUG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43187:SF1">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE DUG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13230">
        <property type="entry name" value="GATase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="3">
        <location>
            <begin position="2"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="362"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3308864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="489" mass="53565" checksum="77B6791F13037349" modified="2024-07-24" version="1">MCRFLVYKGSDEILLSKLVLDPAHSILKQSFDSRLRLDTRRGQNNADGFGIGFYTDAKLGAAPCLFTSTTPAWNCVNLQRLASKTASRLIFAHVRATTEGSLSEDNCHPFCHGSLMWMHNGGLGGWKQIKRRLGERLADKWYLGVVGGTDSEWAFALFLDTLERMGHDPSSQPEKGFGPTVLRKAMLKTIAQINELIDNIPESVVHAENVDTRSLLNFAVTDGHSIICTRYVGSSSDEAASLYYSSGTLWETRAPAPDNQDYHMERSDKGADVILVASEPLTFERENWVNVPTNSILTIHNQTVMVHPIMDRYYDRNPQHRRSTAFVRTKGLSANEKGTPRSGTPFGLPPSVPPIPSLSHFADHPDPHRQRPRGPTIPIVPTSASRSRSPLARAENIAPGQLAQQASLTDIRALTAPPVIRSAPQTPPVQGNIKKKRASLSAIDAAHGGAAGGGLAQYFDNSPITPEPVRTEFGNPNKIAQLFPELALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GZG2</accession>
    <name>A0AAJ0GZG2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">B0T15DRAFT_525930</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">ATP-dependent RNA helicase associated with the nuclear pore complex and essential for mRNA export from the nucleus. May participate in a terminal step of mRNA export through the removal of proteins that accompany mRNA through the nucleopore complex. May also be involved in early transcription.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Associates with the nuclear pore complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the DEAD box helicase family. DDX19/DBP5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3309013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724793.1">
        <property type="nucleotide sequence ID" value="XM_062868878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GZG2"/>
    <dbReference type="GeneID" id="87887707"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17963">
        <property type="entry name" value="DEADc_DDX19_DDX25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000849">
        <property type="entry name" value="ATP-dependent RNA helicase DBP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 17 21" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="11" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="4 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0811">Translocation</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="20">
        <location>
            <begin position="67"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="100"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="280"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="16">
        <location>
            <begin position="67"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAK3309013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="474" mass="52188" checksum="1BDD2DA06A7E7853" modified="2024-07-24" version="1">MADLASRITNPNEAPVDKVTPVAEATGSEQLIDDGGSGGIVDSTYEVEVKLADLQNDASNPLHSSVSSFEELGLAPEILSGLLAMGFKKPSKIQENALPLMLKNPPRNMIAQSQSGTGKTAAFVLTVLSRVDFAQPQQPQALVLAPSRELARQIQKVIQEIGRFCTNLIVQLAVPGSISRETGVRASIVTGTPGTVMDLIRRRQFDVSQMKVLVMDEADNMLDQQGMGEQSVRVRNLLPKETQLLLFSATFPEKVLNFARKFAGDANEIKLRHNELTVKGISQMYMDCPDESKKYDILCKLYGLMTIGSSVIFVKTRESANEIQRRMEADGHKVSALHGAHEGANRDALLDDFRSGRSKVLITTNVLARGIDVSSVSMVINYDIPTKGFGDREPDHETYLHRIGRTGRFGRVGVSITFVYDRNSFDMLSKIAKHYDLDLVQLSPDDWDATEKKVQDIIKSSRARPDYAPNPLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H1D1</accession>
    <name>A0AAJ0H1D1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ARP4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_18427</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725707.1">
        <property type="nucleotide sequence ID" value="XM_062862353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H1D1"/>
    <dbReference type="GeneID" id="87881182"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13395">
        <property type="entry name" value="ASKHA_NBD_Arp4_ACTL6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3309927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="468" mass="51476" checksum="3E851AEB1B4D83E1" modified="2024-07-24" version="1">MSQQPLSSSVQPTDIYGGDEVSALVLDPGYCSTRAGFAGEDHPKLVIPTPYHHINGRDLFGDPIVTPRAGFEVRHYMNRDSVVEDWDAATRAWEYLLVQRLQPPRPTPPSKNRLNVGDDGDVEMGEDGAAADATDALEKPLAENPLLMAEAPWNPPKAREKAIEVCMETWGCPAFWLGRTPVLSSFAAGKPTALVVDVGGANISVAAVHDGILLKRSVQRSPAAGVWLSSQIRSMWKTNEPKVDVVPFFMVESKKPVEAGAPPDARLRTFDFPISDSFRAFEEERVVKEFKESVVEVWRGPGRFMAPGNEDYAKSQPGRVFEMPDGANQMWREQRYRVAEGMWDEAAAYPAASADEPNPSKAQTIPALIKAALDGVDVDLRPNLLSNVVVTGSTSLLNGFNDRLNQELTAMYPGVRIKIHAAGFTSERRHGAWIGGSILASLGTFHQMWISRHEYDENGPSIVEKRCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H1I5</accession>
    <name>A0AAJ0H1I5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA polymerase I-specific transcription initiation factor RRN3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_517356</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRN3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725869.1">
        <property type="nucleotide sequence ID" value="XM_062868308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H1I5"/>
    <dbReference type="GeneID" id="87887137"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001042">
        <property type="term" value="F:RNA polymerase I core binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001181">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007991">
        <property type="entry name" value="RNA_pol_I_trans_ini_fac_RRN3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12790:SF0">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12790">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IA RRN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05327">
        <property type="entry name" value="RRN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="71"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="308"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="649"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="315"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="653"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="693"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3310089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="703" mass="79855" checksum="3C8B775931A09C2C" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H1T3</accession>
    <name>A0AAJ0H1T3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_31557</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726051.1">
        <property type="nucleotide sequence ID" value="XM_062863984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H1T3"/>
    <dbReference type="GeneID" id="87882813"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000245">
        <property type="entry name" value="Short chain dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF4">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3310271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="311" mass="33484" checksum="E3B10BB19F553554" modified="2024-07-24" version="1">MASLLIQKTAWTASSRALLARQHVRSAPVTLVRGFHHSPIQRNQQRSTFLPEFSLKDRVIIVSGGARGVGLTQAEALLEAGAVVHALDRLPDPAQDSDFSRVASRATSELGSRMSYHRVDVRDQSALGKIVGGIAEKEGRIDGLIAAAGIQQETPALEYTAEDSDKMLGVNVTGVFMTAQAVAREMIKRKQKGSLVLIGSMSGTVANRGLICPVYNASKAAVLQLARNLAAEWGEHGIRVNTISPGYIVTAMTASLFEAVPERRTAWPDANMLKRLSYPEEYRGAAVFLLSDASSFMTGADLRIDGGHCAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H2F9</accession>
    <name>A0AAJ0H2F9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">pyridoxal kinase</fullName>
            <ecNumber evidence="2">2.7.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_40421</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pyridoxine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.35" evidence="2"/>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726292.1">
        <property type="nucleotide sequence ID" value="XM_062865241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H2F9"/>
    <dbReference type="GeneID" id="87884070"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008478">
        <property type="term" value="F:pyridoxal kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009443">
        <property type="term" value="P:pyridoxal 5'-phosphate salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01173">
        <property type="entry name" value="pyridoxal_pyridoxamine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004625">
        <property type="entry name" value="PyrdxlKinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00687">
        <property type="entry name" value="pyridox_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534:SF2">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyridoxamine kinase/Phosphomethylpyrimidine kinase" evidence="7">
        <location>
            <begin position="118"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3310512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="359" mass="39203" checksum="0EEFB9721C2CE83B" modified="2024-07-24" version="1">MSDSSPVPETRVLAVASHVVSGYVGNKIAVFSMQSLGCDVAALNTVQFSNHTGYRQWTGSRVSAQEITELYQGLKQSYLDDFDMMLSGYVPGAPALEAVGQIAQELKRKAKPKPGSFFWVLDPVMGDNGKLYVAPDVVPVYKSLVHHADLVLPNQFEAELLSDVEITDMPSIARAIQVMHERYGIPHIIITSVSLPHPDHPVSSLSVVGSSMTSDRRARAFKIVFPAIDCYFCGTGDMFAALMVVRMREAVHNDSGEGLLTNRESWLSDDSVDALDLPLARAAEKVLASMHEVLTKTAETMERTVKKAAAELAAGADGAGPEAEEKKLHLLKSKAAELRLVRHLDSLRFPKVEFRATKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H2V1</accession>
    <name>A0AAJ0H2V1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_489448</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726573.1">
        <property type="nucleotide sequence ID" value="XM_062866601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H2V1"/>
    <dbReference type="GeneID" id="87885430"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451">
        <property type="entry name" value="MARVEL DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451:SF1">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="6">
        <location>
            <begin position="23"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3310793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="163" mass="17439" checksum="804D0E8E8DF65765" modified="2024-07-24" version="1">MKKPTAAAPGRRERLRLKAGLMISIHVFRGYDVPDAWGFLIFCAGWTVLTLIVHPNAGIIFADRAFIGYVRVAVEAVAVLSWLVGFIAVAVEIRTAACSAGRDSCVSLITASVFGAFEWLLLFMVTAALTAMLVSNSSRKPGTSTTGSGAAILKDMAIQKFDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H3A8</accession>
    <name>A0AAJ0H3A8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_489422</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726549.1">
        <property type="nucleotide sequence ID" value="XM_062866599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H3A8"/>
    <dbReference type="GeneID" id="87885428"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3310769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="236" mass="26026" checksum="71E4A9CF43BD8359" modified="2024-07-24" version="1">MLLTSGQVSIAISSGVVFLCTAALFLSGYALQQRTLRDLRAAIQTPKPSPKIFLPDRFKQSTTELPDGTIVTLDEDADDGDTRRKGEAIIEIKPTVLQDEGSRQQYVSGEKPTKTVKGKGRAKEKGGKGSAKEDGPDDNDGELQKPMSRAERRRRIKEEIMQNSQGEGPRGYYRRRRQLPVSRVDDDVFVERGARESLPDSKAERHEEVLEFDGELLCAELLMLSGRSTGGSSLCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H3I3</accession>
    <name>A0AAJ0H3I3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_385537</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726953.1">
        <property type="nucleotide sequence ID" value="XM_062864284.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87883113"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057218">
        <property type="entry name" value="DUF7896"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42031">
        <property type="entry name" value="KEY LIME PATHOGENICITY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42031:SF1">
        <property type="entry name" value="KEY LIME PATHOGENICITY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25438">
        <property type="entry name" value="DUF7896"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="812"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="864"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="1024"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="1051"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="1083"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="1139"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="942"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1169"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1212"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1248"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1183"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1220"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1258"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1287"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1334"/>
            <end position="1355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3311173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1374" mass="152532" checksum="0F10CA4D31AB64C7" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H3N1</accession>
    <name>A0AAJ0H3N1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal peptidase complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_67130</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPCS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727009.1">
        <property type="nucleotide sequence ID" value="XM_062871184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H3N1"/>
    <dbReference type="GeneID" id="87890013"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009582">
        <property type="entry name" value="Spc2/SPCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13085">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 25 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13085:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06703">
        <property type="entry name" value="SPC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="211"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3311229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="231" mass="24856" checksum="47B295F06C13D9F9" modified="2024-07-24" version="1">MAVSQEKITVYNLADLKNTSDDAIPNYLNSLKFRQSHRLTDVRLALGYSAFALAAACFGWDFKFGFESTKYYTAAAVAAYTLLNGALTLWMLYVERGTVYVGTAPSGETLRISTSTKKNVPTYFVTVEVQEKDGKKEVLKISRAFTEWFDAAGHFVAAPFQTLLASSLPVVGKLDPKRAAAPKEDGGAEATYTPEMLDVLAQANVSVVGSAAEEATGSEAAGTKGGKRRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H3N5</accession>
    <name>A0AAJ0H3N5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidohydrolase family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_520866</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727022.1">
        <property type="nucleotide sequence ID" value="XM_062868528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H3N5"/>
    <dbReference type="GeneID" id="87887357"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642">
        <property type="entry name" value="IMIDAZOLONEPROPIONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642:SF21">
        <property type="entry name" value="PERIPLASMIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydrolase 3" evidence="2">
        <location>
            <begin position="124"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3311242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="614" mass="65873" checksum="37C4771E3C854549" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H499</accession>
    <name>A0AAJ0H499_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_482486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727252.1">
        <property type="nucleotide sequence ID" value="XM_062866107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H499"/>
    <dbReference type="GeneID" id="87884936"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="411"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3311472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="448" mass="49174" checksum="A131263FE468A75A" modified="2024-07-24" version="1">MASAHHRKRSRADDLLQEHRPNKIKSRGRLSGPSNFPPEFWDNLSKVWLTPRALRELDRRNSTRPTPELATPAVYTTDLARRSSAFSGSRRTQSTRSTKATSLSAKSGKSSAYGHEFETHLTDHGIYPEGYEYPEDRSTPEPGNQVHQDLSSKFRDFKRKDARATFENDVMATVVPIICGDVDIPSRQNVLFTELAPLTSTYDEVHASVPVAPNFFLEAKAPKGAADVLKRQACYDGAYGARFDMTDSRETFVQGATAFRNARDLAQRYRDQLIQAANAKARQSNTEAPPEAEVRVAIAEHYEDSTADEFVDCEEYASQVVGIENHPAFGDADEALAPPQYLYAEDEEPSQESTSLGAEPAMSFATSFTLSFIQSQTSSKRTRASHSPPSNSRPRKKLDRAERQAHRSAPRRSAGSSAQGSTSSGSAGLPPASASSPPCQTAAYSPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LXZ3</accession>
    <name>A0AAJ0LXZ3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_544495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717523.1">
        <property type="nucleotide sequence ID" value="XM_062870085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LXZ3"/>
    <dbReference type="GeneID" id="87888914"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38122">
        <property type="entry name" value="GLYCOPROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38122:SF1">
        <property type="entry name" value="GLYCOPROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="195"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3301743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="342" mass="36872" checksum="24A5A28868A401B3" modified="2024-07-24" version="1">MLLVPIPSCTRDAMWRPSRFPQATPPFPLPTTNVPTAVSSSSASASDAVPIPGVCYERCNDAAREVQRVGRVPQLCDQDSAFRKYMNLCLGCLNAAGASVSAIGPAEEMVGYCVASPAPLTAFSTASTASTSYTIPTSWLTTSTMLSYFTFSGVGLDGIETLTTSTSAVEVVVTRSDWTGFVHTSTPTANREAQSTSGSTESETSTSNNKAWIAGAVVGSIAGLAVLVGIYCYLLFFFRRRKRRSRKSRNDDDDEPYTGKPELHAESLPGAPRGPPKELDAMPRPPQELEVPTKYYAKPGRLPPCLIAEMPANEIPAREMDVKVQHSEMDVESEKGTEQTRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LYC9</accession>
    <name>A0AAJ0LYC9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="4">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_542092</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="4"/>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717928.1">
        <property type="nucleotide sequence ID" value="XM_062869907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LYC9"/>
    <dbReference type="GeneID" id="87888736"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006598">
        <property type="term" value="P:polyamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000050">
        <property type="entry name" value="Aldehyde dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000012">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43720">
        <property type="entry name" value="2-AMINOMUCONIC SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43720:SF2">
        <property type="entry name" value="2-AMINOMUCONIC SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="77"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3302148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="547" mass="59379" checksum="975BBFF39A11D0DB" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LYS4</accession>
    <name>A0AAJ0LYS4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hyaluronan/mRNA-binding protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_497028</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718348.1">
        <property type="nucleotide sequence ID" value="XM_062867235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LYS4"/>
    <dbReference type="GeneID" id="87886064"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039764">
        <property type="entry name" value="HABP4/SERBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006861">
        <property type="entry name" value="HABP4_PAIRBP1-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019084">
        <property type="entry name" value="STM1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12299:SF17">
        <property type="entry name" value="AT19571P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12299">
        <property type="entry name" value="HYALURONIC ACID-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04774">
        <property type="entry name" value="HABP4_PAI-RBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09598">
        <property type="entry name" value="Stm1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01233">
        <property type="entry name" value="HABP4_PAI-RBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hyaluronan/mRNA-binding protein" evidence="4">
        <location>
            <begin position="104"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="215"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="223"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="259"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="287"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3302568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="322" mass="34620" checksum="875CF875617646C4" modified="2024-07-24" version="1">MSVAHQNIFDVLGNDEEYPPTPAAPVKTVEKTSTHTTKRNTDGLAPSKAPTATGNRRGAAVGGNEAAYRDRNAGRESNRAKPARPNDEAPRGGRRGGYRGRGEGRVGGDRHPTRSAPHSNSDKQAAQGWGAEEGQAELKDEQAGEEIAQTEQKEAEAAGEAVAEEPEEKHITLDQYLAQQAEKKLALEAEAALKVRKPNEGVKDDKWKGFAPLTKKEEEEELFAAREGKAKRERERKQKQLLDVDITRYAAEPERTRGGRGGRGGARGDAGRGRGRGAPRGAPRGAPRGDFRGDFRGGRGRGQENAPLNPNDEAAFPSLGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LYX6</accession>
    <name>A0AAJ0LYX6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetylgalactosaminide beta-1,3-galactosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.122</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0T15DRAFT_495409</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.122" evidence="4"/>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3302836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718616.1">
        <property type="nucleotide sequence ID" value="XM_062867095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LYX6"/>
    <dbReference type="GeneID" id="87885924"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016263">
        <property type="term" value="F:glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026050">
        <property type="entry name" value="C1GALT1/C1GALT1_chp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033:SF47">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033">
        <property type="entry name" value="BETA1,3-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="13">
        <location>
            <begin position="242"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="46"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="78"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3302836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="518" mass="58440" checksum="FFB24AA29F59DAB6" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LYZ2</accession>
    <name>A0AAJ0LYZ2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Oxidoreductase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_401693</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I 23 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3302840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718620.1">
        <property type="nucleotide sequence ID" value="XM_062865126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LYZ2"/>
    <dbReference type="GeneID" id="87883955"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3270:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit I 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01351">
        <property type="entry name" value="NDH1_NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010226">
        <property type="entry name" value="NADH_quinone_OxRdtase_chainI"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01971">
        <property type="entry name" value="NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004538">
        <property type="entry name" value="PRK05888.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004539">
        <property type="entry name" value="PRK05888.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849:SF20">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="768"/>
            <end position="797"/>
        </location>
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        <location>
            <begin position="807"/>
            <end position="836"/>
        </location>
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        </location>
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        </location>
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        </location>
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        </location>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
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                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
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                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ0LZP6_9PEZI</name>
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    </protein>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
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                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
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                <person name="Kuo A."/>
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                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
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                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GO" id="GO:0008237">
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        <property type="evidence" value="ECO:0007669"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3303619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="352" mass="38838" checksum="4A62D5C1EF3499EF" modified="2024-07-24" version="1">MAGPFLTPWQCLRALILFFPCMSFALVDIRAAFNLARPNTGGNCEARINQLNGFFSEADQMTTDAINMLRAAISTTPDIGENERGQAQRAATTWLSALTDADRGVAIDTFRRIRDFLDRGQNADHPQKPAWLFCDDTWLAKHQWTNPVQNQNGAFILVPTSTGTRFKLIQEQYPTRFQQNPGLLPYFAASIGTYVLDLDYGTSSYCGESNLGATQDESPNAATMTLCPVSFNSGASAPAASLGADGGNGPGFQRYAPPSLTMYHELFHLVLGAAQSDDVQVNNAVGNAVGDVNTRLIATRAARAANRGNRAQLQRILRNPESYTWFALQAWYFYRRNQYFNPDENGVVDRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZU8</accession>
    <name>A0AAJ0LZU8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NUDIX hydrolase domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_284774</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719576.1">
        <property type="nucleotide sequence ID" value="XM_062863617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZU8"/>
    <dbReference type="GeneID" id="87882446"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02883">
        <property type="entry name" value="NUDIX_Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43736">
        <property type="entry name" value="ADP-RIBOSE PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43736:SF1">
        <property type="entry name" value="DIHYDRONEOPTERIN TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="32"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3303796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="178" mass="19144" checksum="C0760253CB68C4B7" modified="2024-07-24" version="1">MSATPSRGFTYPPSLAPYNISPAAYLAANPGLKGLVVSAIIIHNSRVLLIQRAAHDGFPLKWECPGGGVDTTDATILHAVCREVHEETGLVVTRLGEKVNVLDFDGWENGAKWTKITFLVVLDDGDEAVVRLNAQEHQDAVWATDAEVASGMCEGREIVFAYGDQKQLVLDALSANGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZV7</accession>
    <name>A0AAJ0LZV7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Eukaryotic membrane protein family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_513958</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAPT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719606.1">
        <property type="nucleotide sequence ID" value="XM_062868086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZV7"/>
    <dbReference type="GeneID" id="87886915"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008010">
        <property type="entry name" value="Tatp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13317">
        <property type="entry name" value="TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13317:SF4">
        <property type="entry name" value="TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05346">
        <property type="entry name" value="DUF747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="855"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="390"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="436"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="214"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="259"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="400"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3303826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="978" mass="107220" checksum="E6AC6E5A91335759" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M026</accession>
    <name>A0AAJ0M026_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Centromere protein Chl4/mis15/CENP-N</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_226698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719789.1">
        <property type="nucleotide sequence ID" value="XM_062862888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M026"/>
    <dbReference type="GeneID" id="87881717"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007902">
        <property type="entry name" value="Chl4/mis15/CENP-N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05238">
        <property type="entry name" value="CENP-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3304009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="579" mass="63380" checksum="820C9148E29A00CF" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M033</accession>
    <name>A0AAJ0M033_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">V-type proton ATPase subunit a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0T15DRAFT_568080</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase 116 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719832.1">
        <property type="nucleotide sequence ID" value="XM_062870746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M033"/>
    <dbReference type="GeneID" id="87889575"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002490">
        <property type="entry name" value="V-ATPase_116kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026028">
        <property type="entry name" value="V-type_ATPase_116kDa_su_euka"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629:SF63">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629">
        <property type="entry name" value="VACUOLAR PROTON ATPASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01496">
        <property type="entry name" value="V_ATPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001293">
        <property type="entry name" value="ATP6V0A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="422"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="467"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="548"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="586"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="642"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="793"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="688"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3304052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="864" mass="98342" checksum="0B30B606801C10B2" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M058</accession>
    <name>A0AAJ0M058_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ima1 N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_231104</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719907.1">
        <property type="nucleotide sequence ID" value="XM_062862945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M058"/>
    <dbReference type="GeneID" id="87881774"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034506">
        <property type="term" value="C:chromosome, centromeric core domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034992">
        <property type="term" value="C:microtubule organizing center attachment site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071765">
        <property type="term" value="P:nuclear inner membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042321">
        <property type="entry name" value="Ima1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018617">
        <property type="entry name" value="Ima1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28538">
        <property type="entry name" value="INTEGRAL INNER NUCLEAR MEMBRANE PROTEIN IMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28538:SF1">
        <property type="entry name" value="INTEGRAL INNER NUCLEAR MEMBRANE PROTEIN IMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09779">
        <property type="entry name" value="Ima1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Ima1 N-terminal" evidence="7">
        <location>
            <begin position="10"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="46"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="370"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="470"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="470"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3304127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="628" mass="70293" checksum="C00545A101A16DCF" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M0P5</accession>
    <name>A0AAJ0M0P5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_400471</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720462.1">
        <property type="nucleotide sequence ID" value="XM_062865063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M0P5"/>
    <dbReference type="GeneID" id="87883892"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3304682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="222" mass="23886" checksum="CC0FB0F187752BF1" modified="2024-07-24" version="1">MPSSNWTTASCPFLAAYNSGVWPDPLSLVSTSTLPVPSSNWTTALCPFSMAYNSGVRLYMLSLVSRSTLPVPSSNYTMALCLSLAAHNSGVWPLLSFASTLTLPMPSSNWTIASRPFPAAYDSGVRPLLSFVSTSTLPVPSSNRTTASRLFPAAYDSGVRLYMLSLVSTSTLPMPSSNWAIASCPFLAAYNSRVRPSLSVESTWALYSRRSSITLRLPFSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M0R4</accession>
    <name>A0AAJ0M0R4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_249264</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720418.1">
        <property type="nucleotide sequence ID" value="XM_062863151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M0R4"/>
    <dbReference type="GeneID" id="87881980"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF30">
        <property type="entry name" value="MID2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042566878" evidence="7">
        <location>
            <begin position="26"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="274"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="469"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="280"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="331"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="469"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="494"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="531"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3304638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="574" mass="58971" checksum="53141CE8574B4F55" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M109</accession>
    <name>A0AAJ0M109_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cinnamoyl-CoA reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_433529</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3304999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720779.1">
        <property type="nucleotide sequence ID" value="XM_062865778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M109"/>
    <dbReference type="GeneID" id="87884607"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05251">
        <property type="entry name" value="NmrA_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF7">
        <property type="entry name" value="NMRA LIKE REDOX SENSOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="9"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3304999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="336" mass="37037" checksum="27CFB3453C226B33" modified="2024-07-24" version="1">MSTSSSHPKVIVVLGATGHQGGGVVRALLKSKSWIVRAGTRDPGSSKAQKLLAEEQNDDGQLEVVAANVYDIEALRKAFAGAYGVFAITSERHPDKEIVDEEDMQHEIEAGRNIVLAAKECNVQHFVFSSLPDMMQATSGQFPKLYHMNNKHAVEKIAREELPGRVTCLIPGFFYTNLQWRQYCRRQEDGVARFCYPIPSDQVTQWTDPEYDMGSFAAKVFNLGVDRTRGKTYLVMSPPVTPQQIAETFTRVTGQPAIHSPSSAEEFGDLTAPLVGPAFKEDAKQMMQWAAIAPKSKVAYGALDPQVDRSAEELGLTASSFEAWLKRSGWTGPDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M1A0</accession>
    <name>A0AAJ0M1A0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ADC synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_555238</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721032.1">
        <property type="nucleotide sequence ID" value="XM_062870386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M1A0"/>
    <dbReference type="GeneID" id="87889215"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="entry name" value="Anthranilate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="AMINOBENZOATE/ANTHRANILATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236:SF9">
        <property type="entry name" value="ANTHRANILATE SYNTHASE COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="ADC synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anthranilate synthase component I N-terminal" evidence="3">
        <location>
            <begin position="67"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate-utilising enzyme C-terminal" evidence="2">
        <location>
            <begin position="246"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate-utilising enzyme C-terminal" evidence="2">
        <location>
            <begin position="334"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate-utilising enzyme C-terminal" evidence="2">
        <location>
            <begin position="503"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3305252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="596" mass="65688" checksum="238DC8C92663539B" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M1G8</accession>
    <name>A0AAJ0M1G8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lecithin:cholesterol acyltransferase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_532466</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721274.1">
        <property type="nucleotide sequence ID" value="XM_062869312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M1G8"/>
    <dbReference type="GeneID" id="87888141"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003386">
        <property type="entry name" value="LACT/PDAT_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02450">
        <property type="entry name" value="LCAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3305494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="624" mass="69908" checksum="44FC317E03AA89BD" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M1L8</accession>
    <name>A0AAJ0M1L8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 11">Glycylpeptide N-tetradecanoyltransferase</fullName>
            <ecNumber evidence="5 11">2.3.1.97</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0T15DRAFT_511551</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>N-terminal glycyl-[protein] + tetradecanoyl-CoA = N-tetradecanoylglycyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15521"/>
            <dbReference type="Rhea" id="RHEA-COMP:12666"/>
            <dbReference type="Rhea" id="RHEA-COMP:12667"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="ChEBI" id="CHEBI:64723"/>
            <dbReference type="ChEBI" id="CHEBI:133050"/>
            <dbReference type="EC" id="2.3.1.97"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the NMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.97" evidence="5 11"/>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721436.1">
        <property type="nucleotide sequence ID" value="XM_062867919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M1L8"/>
    <dbReference type="GeneID" id="87886748"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004379">
        <property type="term" value="F:glycylpeptide N-tetradecanoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000042">
        <property type="entry name" value="Glycylpeptide N-tetradecanoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000056">
        <property type="entry name" value="Glycylpeptide N-tetradecanoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000903">
        <property type="entry name" value="NMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022677">
        <property type="entry name" value="NMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022678">
        <property type="entry name" value="NMT_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022676">
        <property type="entry name" value="NMT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377:SF5">
        <property type="entry name" value="GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377">
        <property type="entry name" value="N-MYRISTOYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01233">
        <property type="entry name" value="NMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02799">
        <property type="entry name" value="NMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00975">
        <property type="entry name" value="NMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00976">
        <property type="entry name" value="NMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycylpeptide N-tetradecanoyltransferase N-terminal" evidence="14">
        <location>
            <begin position="185"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Glycylpeptide N-tetradecanoyltransferase C-terminal" evidence="15">
        <location>
            <begin position="352"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3305656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="570" mass="64234" checksum="71355172B2820BA0" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M3M1</accession>
    <name>A0AAJ0M3M1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbohydrate esterase family 16 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_181126</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723299.1">
        <property type="nucleotide sequence ID" value="XM_062862310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M3M1"/>
    <dbReference type="GeneID" id="87881139"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01846">
        <property type="entry name" value="fatty_acyltransferase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051058">
        <property type="entry name" value="GDSL_Est/Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648">
        <property type="entry name" value="GDSL LIPASE/ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648:SF22">
        <property type="entry name" value="GDSL LIPASE_ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042496986" evidence="2">
        <location>
            <begin position="17"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3307519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="342" mass="37379" checksum="EDC0DD3DE9E7615F" modified="2024-07-24" version="1">MMLVSFILAGASAALATSNNGGFQTLVTFGDSYTDNGRLGYYINNGGKAPPPGVYHPVTNTTASGGLSWAQYAAQDAGANLMDYAVSGAVCSNEVSPRWLDIINKPFPAVLEDELPSFQADVAYKSLYPHRTAANTVYAVWIGTNDLGFKAFLSDSQTPGKTISDFVSCVFSVFDHIYKTGGRRFVLLNTAPLELAPLYAEPDNGGTGDSQFWTDKTQYNITEYGQKMKQYASSVNTMYEYGVPVQVALKNRWPKATFDIFDVHSLLLDIFDEPAKYLDAPRNTSGYYHHCPPAGSPCVNQPGSLDGYLWYDELHPSNKTSSVIAKNFLDVVAGKSKYGTRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M3Q5</accession>
    <name>A0AAJ0M3Q5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_89890</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the REXO1/REXO3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3307921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723701.1">
        <property type="nucleotide sequence ID" value="XM_062871432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M3Q5"/>
    <dbReference type="GeneID" id="87890261"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06145">
        <property type="entry name" value="REX1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034922">
        <property type="entry name" value="REX1-like_exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF112">
        <property type="entry name" value="RNA EXONUCLEASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="7">
        <location>
            <begin position="443"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="32"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="505"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="660"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="180"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="125"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="266"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="515"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3307921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="683" mass="75286" checksum="147B7E36FB0C6824" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M3Y9</accession>
    <name>A0AAJ0M3Y9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DWNN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_97950</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723883.1">
        <property type="nucleotide sequence ID" value="XM_062871510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M3Y9"/>
    <dbReference type="GeneID" id="87890339"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16620">
        <property type="entry name" value="vRING-HC-C4C4_RBBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014891">
        <property type="entry name" value="DWNN_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033489">
        <property type="entry name" value="RBBP6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025829">
        <property type="entry name" value="Zn_knuckle_CX2CX3GHX4C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15439:SF0">
        <property type="entry name" value="CELL DIVISION CYCLE AND APOPTOSIS REGULATOR PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15439">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08783">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13696">
        <property type="entry name" value="zf-CCHC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01180">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51282">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DWNN" evidence="9">
        <location>
            <begin position="5"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="8">
        <location>
            <begin position="180"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="358"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="582"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="397"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="582"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="592"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="623"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3308103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="643" mass="69128" checksum="6276AC609FC484EF" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M4J5</accession>
    <name>A0AAJ0M4J5_9PEZI</name>
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        <recommendedName>
            <fullName evidence="2">Mmc1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">B0T15DRAFT_491330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724558.1">
        <property type="nucleotide sequence ID" value="XM_062866765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M4J5"/>
    <dbReference type="GeneID" id="87885594"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056196">
        <property type="entry name" value="Mmc1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38644">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38644:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23868">
        <property type="entry name" value="Mmc1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23867">
        <property type="entry name" value="Mmc1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="407"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3308778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="660" mass="70556" checksum="F21F98F05C7F5E98" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M546</accession>
    <name>A0AAJ0M546_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Oligopeptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_481132</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725201.1">
        <property type="nucleotide sequence ID" value="XM_062866008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M546"/>
    <dbReference type="GeneID" id="87884837"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="362"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="467"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3309421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="542" mass="59297" checksum="9355FAF1E5401828" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M5W2</accession>
    <name>A0AAJ0M5W2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Autophagy protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_19980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725757.1">
        <property type="nucleotide sequence ID" value="XM_062862561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M5W2"/>
    <dbReference type="GeneID" id="87881390"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3309977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="345" mass="38842" checksum="99CA6B2D92541543" modified="2024-07-24" version="1">MGWFDGWFGSDNSGSDPLKRLDPKLREFLEKESPVKYSNTPAQQPTQPQSQPSPQPQQQQQQQQHQQQAPQSSSDTQQQQQQNATPPAVPPESLFQDGRYAHLWKTYRPLAAIEAETKSDSEKLSDVLDAYKERRAQIGRAALENCAEEQFTWATCMKSGSWTARMTLCRDEVHRFERCYSAQSRLLKALGYLSVHGRDARVDEDIQMRADELYHRMLDQEREIERAKAEGRAAPAFKPLLEDQKPVVPAAAAAAAPAIVDAAEPSATTVAAWKEKLEKLPPEEREAEEKALRAEHRANAEMAARIQGLWQEQAKEREARKAAGKETIMDKFSAMVGTWTGPKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M5Y0</accession>
    <name>A0AAJ0M5Y0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL2m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_518024</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726071.1">
        <property type="nucleotide sequence ID" value="XM_062868343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M5Y0"/>
    <dbReference type="GeneID" id="87887172"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000034">
        <property type="entry name" value="50S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000128">
        <property type="entry name" value="50S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.950.10:FF:000001">
        <property type="entry name" value="50S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="entry name" value="Ribosomal protein L2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_uL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005880">
        <property type="entry name" value="Ribosomal_uL2_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_uL2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_uL2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_uL2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Ribosomal_uL2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01171">
        <property type="entry name" value="rplB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="RIBOSOMAL PROTEIN L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL2 RNA-binding" evidence="10">
        <location>
            <begin position="105"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL2 C-terminal" evidence="9">
        <location>
            <begin position="208"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="320"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="329"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00069872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3310291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="382" mass="41908" checksum="EC8EA0A83A57E949" modified="2024-07-24" version="1">MLQPRLRPLVVGRAASLTSMFQSSLRLEAIRRYASAAQSESNNVSGEDDAGFGAPSTELQAVKMRTYKPRTPGLRHLKRPINDHLWKGRPYLPLTFPKKGHGKGGRNNTGRITIRHRGGGAKRRIRIVDFDRWTPGPHTVERIEYDPGRSAHIALLTEQATGKKSYIVAAEGMRAGDVVQSYRAGIPQDLLDSMGGVVDPGILAARTAWRGNCLPMHMIPVGTVVYNVGSRPQGGAVFCRSAGTYATIISKEEETRDDGTKVMTGKHVIVRLQSGEIRKVSKDACATIGVASNIMHQYRQLGKAGRSRWLNIRPTVRGVAMNANDHPHGGGRGKSKGNRHPVSPWGQPAKGGFKTRIKSNVNKWVVTPRVRNMGKRRDKNTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M6A2</accession>
    <name>A0AAJ0M6A2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RNA polymerase II subunit A C-terminal domain phosphatase SSU72</fullName>
            <shortName evidence="10">CTD phosphatase SSU72</shortName>
            <ecNumber evidence="10">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0T15DRAFT_518548</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. SSU72 is required for 3'-end formation of snoRNAs.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Processively dephosphorylates Ser-5 of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (RPB1).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Component of the cleavage and polyadenylation factor (CPF) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SSU72 phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="10"/>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726225.1">
        <property type="nucleotide sequence ID" value="XM_062868371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M6A2"/>
    <dbReference type="GeneID" id="87887200"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000039">
        <property type="entry name" value="RNA polymerase II subunit A C-terminal domain phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000189">
        <property type="entry name" value="SSU72p Phosphatase and transcription/RNA-processing factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006811">
        <property type="entry name" value="RNA_pol_II_suA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20383">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04722">
        <property type="entry name" value="Ssu72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6 10" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU369031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3310445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="257" mass="28259" checksum="A0E50E22F8ABA38C" modified="2024-07-24" version="1">MDPASGSEGSSAPAQNGQPEDGSGFKLKFCTVCASNQNRSMEGHLRLAQANFPVISFGTGSLVRLPGPTVTQPNVYKFNETSYDSIYRELEAKDPRLYRANGLLNMLGRNRLIKWGPERWQDWNVGMPRVKHEKDKGSVGMEGGVPDVVITCEERCWDAVVDDLLNRGSPLNRAVHVINIDIKDNHQDASIGGGAIVDLADSLNKAAMEEREKVGAAAFDAGGAASRASFDERVPEVLAEWQQRWPDLPSTWTLSWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M6F9</accession>
    <name>A0AAJ0M6F9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_51408</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726613.1">
        <property type="nucleotide sequence ID" value="XM_062868094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M6F9"/>
    <dbReference type="GeneID" id="87886923"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3310833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="166" mass="18557" checksum="491E493D01CBB132" modified="2024-07-24" version="1">MVHRPVRRYMRMSAWGGWTEAQIRSPRPSERWRLFCFDRRGDGKNWQWPLFGWKALGSWVCVYIYNASCGALDSPWLLHCGHGGTAPGLECKRLPHQIPDCRDSCAPFFAGGLGFPPSSRELARSGAGLNGSKGMSNLPAAARGSLPRWLAMRRPSIIRRPLGACF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M6G7</accession>
    <name>A0AAJ0M6G7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Coatomer subunit zeta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0T15DRAFT_45759</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Golgi apparatus membrane</location>
            <topology evidence="1 12">Peripheral membrane protein</topology>
            <orientation evidence="1 12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cytoplasmic vesicle</location>
            <location evidence="12">COPI-coated vesicle membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726464.1">
        <property type="nucleotide sequence ID" value="XM_062865965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M6G7"/>
    <dbReference type="GeneID" id="87884794"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14829">
        <property type="entry name" value="Zeta-COP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000013">
        <property type="entry name" value="Coatomer subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039652">
        <property type="entry name" value="Coatomer_zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11043:SF0">
        <property type="entry name" value="COATOMER SUBUNIT ZETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11043">
        <property type="entry name" value="ZETA-COAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 12" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="14">
        <location>
            <begin position="51"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3310684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="202" mass="22424" checksum="9B3BF14DCBE6F125" modified="2024-07-24" version="1">MSPGMSLYSVNAILILSSEDGSRIFTKYYTPPHQATQPSGAAPASSSQNPYPDKTSQTRFEKALLQKTAKQTGDILLFDNRIVLYKMESDVALYVVGSVDDNEILLYNVLLALRDSLHLLFKQSVDKRTIIENYDLVSLAIDEICDDGVVLETDPTIIVQRCSRAPSQDVNLSRIDPFSEQGVNNLAQLGKAKLTDWLRQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M6Z5</accession>
    <name>A0AAJ0M6Z5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_489804</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Part of the multisubunit transport protein particle (TRAPP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
            <location evidence="7">cis-Golgi network</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAPP small subunits family. TRAPPC4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726960.1">
        <property type="nucleotide sequence ID" value="XM_062866629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M6Z5"/>
    <dbReference type="GeneID" id="87885458"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14856">
        <property type="entry name" value="TRAPPC4_synbindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.70:FF:000007">
        <property type="entry name" value="Putative sybindin-like family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007233">
        <property type="entry name" value="TRAPPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249:SF15">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04099">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01399">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="5 7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3311180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="159" mass="18074" checksum="4CA3D5F1DEAB450F" modified="2024-07-24" version="1">MTRTVFALIIINKAGGLIYNRSFHEGGLNKISTNDYLVLAGTFHGVHAITARLNPLKTPAAKRSSTSSTGSLTRPELPSGLEVLESENFRMQCFTTLTGIKFLLFTDTTQANVDLTMRRVYDMYTDYVMKNPFYQLEMPVRCDMFDRKLGSYIREINNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M735</accession>
    <name>A0AAJ0M735_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_490101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727273.1">
        <property type="nucleotide sequence ID" value="XM_062866653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M735"/>
    <dbReference type="GeneID" id="87885482"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12254">
        <property type="entry name" value="RRM_hnRNPH_ESRPs_RBM12_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3311493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="784" mass="86623" checksum="C1150007B8999532" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M7B1</accession>
    <name>A0AAJ0M7B1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin-related protein 2/3 complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_482502</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
            <location evidence="6">Cytoskeleton</location>
            <location evidence="6">Actin patch</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ARPC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727272.1">
        <property type="nucleotide sequence ID" value="XM_062866109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M7B1"/>
    <dbReference type="GeneID" id="87884938"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1460.20:FF:000001">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034666">
        <property type="entry name" value="ARPC2/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008384">
        <property type="entry name" value="ARPC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22629:SF0">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22629">
        <property type="entry name" value="ARP2/3 COMPLEX 20 KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05856">
        <property type="entry name" value="ARPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039100">
        <property type="entry name" value="ARPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69645">
        <property type="entry name" value="Arp2/3 complex subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00054835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR039100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3311492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="182" mass="20896" checksum="9A07909FEABE1A20" modified="2024-07-24" version="1">MSQSLRPYLQAVRSSLTAALCLSNFASQTAERHNVPEVEARTSPEVLLTPLTIARNENERVLIEPSINSIRISIKIKQADEIEHILVHKFTRFLTQRAESFFILRRKPIKGYDISFLITNFHTEEMLKHKLVDFIIQFMEEVDKEISEMKLFLNARARFVAESFLTPVRPGIPLSSMAPISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M7C8</accession>
    <name>A0AAJ0M7C8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_549162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727332.1">
        <property type="nucleotide sequence ID" value="XM_062870210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M7C8"/>
    <dbReference type="GeneID" id="87889039"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3311552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="865" mass="95020" checksum="A3B10969DABF4A7E" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GKJ1</accession>
    <name>A0AAJ0GKJ1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_318325</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717411.1">
        <property type="nucleotide sequence ID" value="XM_062864024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GKJ1"/>
    <dbReference type="GeneID" id="87882853"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000008">
        <property type="entry name" value="Alpha-ketoglutarate-dependent taurine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF9">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT TAURINE DIOXYGENASE (AFU_ORTHOLOGUE AFUA_3G01010)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="86"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3301631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="385" mass="43434" checksum="26794B444035F978" modified="2024-07-24" version="1">MAPAAIDESIVDTVQPRKDTLTLPEAARERLTKAGIDLSNGYPFRPAVPIYLQDVYKIRNEERPYEDAGARADKSKKHLFSAATKVTDLTTHIGTEVEGLQLKDLTPEQRDELALLIAERSVVFFRNQDISPQQQKELGEWFGEVEVHPQTPQVPGVPGVTVIWPDLFAQEREANFRRPGGASSWHSDLVHERQPAGVTHLHNDTIPPVGGDTLWASGYGAYEKLSPEFRKLIDGKYAVYRSAHPYLDRENPTAGPKYIERIHPLVRVHPATGWKALWVNRAMTVRIVGLDKAESDVILNYLYDVYEKNVDIQVRFKWTPGTSALWDNRITIHNASWDYGGRHPRHGTRVTSLAEVPYFDPNAPTRRQALGLLDEDEKKALEPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GKN2</accession>
    <name>A0AAJ0GKN2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_487912</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717474.1">
        <property type="nucleotide sequence ID" value="XM_062866466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GKN2"/>
    <dbReference type="GeneID" id="87885295"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050723">
        <property type="entry name" value="CFA/CMAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43667">
        <property type="entry name" value="CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43667:SF1">
        <property type="entry name" value="CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="5">
        <location>
            <begin position="83"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3301694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="255" mass="28639" checksum="B8BAB44E6388CFA8" modified="2024-07-24" version="1">MSASIPTPIPPPDVKDRLKESYNAIAEAYMNWSAGRHNHLRFNYTAELLKLLRRDRLHPTTAGGDSSPPQDGGDVSLGGLRALELGCGCGVPVIGTLLARGFEVLGVDLSSTQVQMATRKYFPDEVQNGQLVVVEKDMMELTYPPGEFDVVVALYSLIHLPRNEQRVMMERVHRWLKPGGMILMNYSVEELEGEVIEKWLGQEKGWVYWSAWGKDKMLDMLDELEFKVLLQEVKGDEGTDASFLWVIAQKENGNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GL14</accession>
    <name>A0AAJ0GL14_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_578120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717666.1">
        <property type="nucleotide sequence ID" value="XM_062871087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GL14"/>
    <dbReference type="GeneID" id="87889916"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3301886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="134" mass="15105" checksum="A37096DD12693843" modified="2024-07-24" version="1">MVPNQDMNKHREPGCTAVTPNKKYYKVGNSFINVMHINRHWQDPSWCSFIGNLWHEDEGWDADIEYWEQRHTISTRGIIPQGNRPGPHTGQPRSPGDTSDWDGTGRHNDEEGQEEVHGGGGAGVPQVTPPRLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GL37</accession>
    <name>A0AAJ0GL37_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">KRI1-like family C-terminal-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_286845</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KRI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAK3301930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062863650.1"/>
    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Kri1"/>
    </dbReference>
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        <property type="entry name" value="Kri1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14490:SF5">
        <property type="entry name" value="PROTEIN KRI1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14490">
        <property type="entry name" value="ZINC FINGER, ZZ TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05178">
        <property type="entry name" value="Kri1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kri1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kri1-like C-terminal" evidence="3">
        <location>
            <begin position="519"/>
            <end position="609"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="320"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="408"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="583"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="607"/>
            <end position="684"/>
        </location>
    </feature>
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        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="51"/>
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    </feature>
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        <location>
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        </location>
    </feature>
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            <begin position="322"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="411"/>
            <end position="429"/>
        </location>
    </feature>
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        </location>
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            <end position="602"/>
        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="667"/>
            <end position="678"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="Pfam" id="PF12936"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3301930.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the TCTP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3301960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Translationally-controlled tumor protein homolog"/>
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    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.10">
        <property type="entry name" value="Metal Binding Protein, Guanine Nucleotide Exchange Factor, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
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        <property type="entry name" value="Mss4/transl-control_tumour"/>
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        <property type="entry name" value="TCTP"/>
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        <property type="entry name" value="Translation_control_tumour_CS"/>
    </dbReference>
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        <property type="entry name" value="Translational_control_tumour_p"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991">
        <property type="entry name" value="TRANSLATIONALLY CONTROLLED TUMOR PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991:SF0">
        <property type="entry name" value="TRANSLATIONALLY-CONTROLLED TUMOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TCTPROTEIN"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01133"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51797"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3301960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GLC1</accession>
    <name>A0AAJ0GLC1_9PEZI</name>
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        <recommendedName>
            <fullName evidence="9">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_404659</name>
    </gene>
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            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM170 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717787.1">
        <property type="nucleotide sequence ID" value="XM_062865261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GLC1"/>
    <dbReference type="GeneID" id="87884090"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019334">
        <property type="entry name" value="TMEM170A/B/YPR153W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22779">
        <property type="entry name" value="SD17342P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22779:SF6">
        <property type="entry name" value="SD17342P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10190">
        <property type="entry name" value="Tmemb_170"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3302007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="143" mass="15922" checksum="0DA548B12D686FBC" modified="2024-07-24" version="1">MVRSASVVRRDTPAEYTVPPFPSLFWPPQDGTVILYELDDMWKFTLYWTLILYGLFHLGAVGVAVLMQGGKRSSSWKYLWLVPLVYALIAAFEGLLAGTLVGLIVGASYIVGGYTMSTWIPFVWGWVNVLVLLVSSFRIQGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GLJ9</accession>
    <name>A0AAJ0GLJ9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="19">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">B0T15DRAFT_295097</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 19">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38567"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:38568"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="19"/>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717949.1">
        <property type="nucleotide sequence ID" value="XM_062863752.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87882581"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006892">
        <property type="term" value="P:post-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02073">
        <property type="entry name" value="P-type_ATPase_APLT_Dnf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000026">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000047">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000010">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF150">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 18 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 17 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 19" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="491"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="546"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1056"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1096"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1139"/>
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            <begin position="1175"/>
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    <feature type="transmembrane region" description="Helical" evidence="19">
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            <begin position="1204"/>
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            <begin position="227"/>
            <end position="293"/>
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    <feature type="domain" description="P-type ATPase A" evidence="21">
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            <begin position="322"/>
            <end position="393"/>
        </location>
    </feature>
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        <location>
            <begin position="1025"/>
            <end position="1276"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
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            <position position="608"/>
        </location>
    </feature>
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            <position position="608"/>
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        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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            <position position="608"/>
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        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
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        <location>
            <position position="609"/>
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        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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            <dbReference type="ChEBI" id="CHEBI:18420"/>
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            <name>Mg(2+)</name>
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    <evidence type="ECO:0000256" key="1">
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        <source>
            <dbReference type="ARBA" id="ARBA00004166"/>
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        <source>
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            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023034"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049128"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00051303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
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    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
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    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KAK3302169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1354" mass="150446" checksum="744478C88ED3B075" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GLR1</accession>
    <name>A0AAJ0GLR1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chaperonin 10-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_542340</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718012.1">
        <property type="nucleotide sequence ID" value="XM_062869917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GLR1"/>
    <dbReference type="GeneID" id="87888746"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813:SF2">
        <property type="entry name" value="DEHYDROGENASE, ZINC-CONTAINING, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02810)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="7">
        <location>
            <begin position="33"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="6">
        <location>
            <begin position="189"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3302232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="289" mass="30977" checksum="24552CA3DFC7CE6E" modified="2024-07-24" version="1">MMSDLPATMKAVVFHGPKHVAVEDRPVPKLQHPRDIIVKVQATALCGSELHVFRGHQPSATGFIMGHEFVGTVVEAGEEVKSVALGDKVVAPFTVSCMECFYCTRGFSARCENCLLFGCPALDGGQAEYVRVPYADGTVVKAPAEIDDRALILMADIFPTGFFGARNAFRMLQPQPASEATVVVVGCGPVGLCAIASALEYRPKHLFAVDSVPSRLELARRLGAEPVNFLDGMEVMQRRVKEVTDGRGADAVIEVVGLSPALRTAFDLLRPFGVISSIGVHNAEVGLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GLS7</accession>
    <name>A0AAJ0GLS7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">methionine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Methionyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B0T15DRAFT_542589</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Met) + L-methionine + ATP = L-methionyl-tRNA(Met) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="3"/>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718089.1">
        <property type="nucleotide sequence ID" value="XM_062869932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GLS7"/>
    <dbReference type="GeneID" id="87888761"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07957">
        <property type="entry name" value="Anticodon_Ia_Met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000031">
        <property type="entry name" value="Putative Methionyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.20">
        <property type="entry name" value="Methionyl-tRNA synthetase, Zn-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023458">
        <property type="entry name" value="Met-tRNA_ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029038">
        <property type="entry name" value="MetRS_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765">
        <property type="entry name" value="METHIONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765:SF1">
        <property type="entry name" value="METHIONINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19303">
        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57770">
        <property type="entry name" value="Methionyl-tRNA synthetase (MetRS), Zn-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13 17" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="15">
        <location>
            <begin position="19"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl-tRNA synthetase anticodon-binding" evidence="16">
        <location>
            <begin position="465"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="620"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="661"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF19303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK3302309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="689" mass="76300" checksum="7893FAB54D6AAAE9" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GLW6</accession>
    <name>A0AAJ0GLW6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_303283</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718156.1">
        <property type="nucleotide sequence ID" value="XM_062863837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GLW6"/>
    <dbReference type="GeneID" id="87882666"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042570773" evidence="2">
        <location>
            <begin position="23"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="540"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="251"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="595"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3302376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="620" mass="67667" checksum="15D25F1B1A224805" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GLY0</accession>
    <name>A0AAJ0GLY0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Saccharopine dehydrogenase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_303033</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718148.1">
        <property type="nucleotide sequence ID" value="XM_062863834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GLY0"/>
    <dbReference type="GeneID" id="87882663"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000592">
        <property type="entry name" value="Similar to saccharopine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051276">
        <property type="entry name" value="Saccharopine_DH-like_oxidrdct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286:SF5">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Saccharopine dehydrogenase NADP binding" evidence="3">
        <location>
            <begin position="12"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3302368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="422" mass="45804" checksum="39200A46C171DED8" modified="2024-07-24" version="1">MPSKVHGRQFDVVVFGASGYTGKYTAQYITTHLPTDLKWAVAGRSQSKLEEVVAECKKLNPDRVQPGIEICSLTDEDLAGLAKKTFILITTVGPYGKLGEHAFKACAENGTHYLDVTGEVPFVAKMLKKYEAAAKQSGALMFPQIGIESAPPDLVTFSLASFIRSEFSSTTRDVTVSIHHLKSAPSGGTLSTAFTLLDNFSVSDLRAAYTPFALSPVPRPATNTTPQPSLLSRLTGLVTVPSLGLLTTSIAAATDAATVQRTWGLLSTLPSPRREQFYGPHFSFREYMRPRNWLTGMALHFGLIVFRLVLATPFLRRIVARMVTQPGEGPEAEVAKGDEIEYRGVAHADVDGAGREGAFCRAWFRGSTYYLTGIFLAEAAATLLQEDVGLPGGVYTPACLGQPFIERLNQAGFHIETKRLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GMM9</accession>
    <name>A0AAJ0GMM9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">UNC-like C-terminal-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_309289</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718325.1">
        <property type="nucleotide sequence ID" value="XM_062863902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GMM9"/>
    <dbReference type="GeneID" id="87882731"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000082">
        <property type="entry name" value="Sad1/UNC domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045120">
        <property type="entry name" value="Suco/Slp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953">
        <property type="entry name" value="MEMBRANE PROTEIN CH1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953:SF0">
        <property type="entry name" value="SUN DOMAIN-CONTAINING OSSIFICATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042472467" evidence="7">
        <location>
            <begin position="28"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="domain" description="SUN" evidence="8">
        <location>
            <begin position="211"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="90"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="131"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="377"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="447"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="738"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="804"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="661"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="449"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="488"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="530"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="555"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="570"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="756"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="834"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="845"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="858"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="910"/>
            <end position="920"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3302545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="964" mass="105275" checksum="8B8DBB6078B9C31F" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GN02</accession>
    <name>A0AAJ0GN02_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">DUF221-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0T15DRAFT_543745</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718505.1">
        <property type="nucleotide sequence ID" value="XM_062870017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GN02"/>
    <dbReference type="GeneID" id="87888846"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022257">
        <property type="entry name" value="PHM7_ext"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF53">
        <property type="entry name" value="DUF221 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12621">
        <property type="entry name" value="PHM7_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="486"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="532"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="690"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="737"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="765"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="12">
        <location>
            <begin position="51"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="13">
        <location>
            <begin position="220"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="10">
        <location>
            <begin position="484"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="domain" description="10TM putative phosphate transporter extracellular tail" evidence="11">
        <location>
            <begin position="934"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="804"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="258"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="804"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="837"/>
            <end position="853"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3302725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1053" mass="118439" checksum="1484B89566476D06" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GN74</accession>
    <name>A0AAJ0GN74_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_257681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3302845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718625.1">
        <property type="nucleotide sequence ID" value="XM_062863269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GN74"/>
    <dbReference type="GeneID" id="87882098"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3302845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="98" mass="10531" checksum="AA3B976949C61EB8" modified="2024-07-24" version="1">MKQAYSLPRQPGLLHSPPCGGGPKPASRGHLVRNVNPSAAILGASLRPPLPQDAHDAHRDSTGKSWHDAVLIPSDDESDADLNGSRSDPRLSHRLTRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GND8</accession>
    <name>A0AAJ0GND8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial import inner membrane translocase subunit TIM16</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Mitochondrial import inner membrane translocase subunit tim16</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 12">Presequence translocated-associated motor subunit PAM16</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0T15DRAFT_266573</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TIM16/PAM16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718983.1">
        <property type="nucleotide sequence ID" value="XM_062863416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GND8"/>
    <dbReference type="GeneID" id="87882245"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000006">
        <property type="entry name" value="Import inner membrane translocase subunit TIM16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005341">
        <property type="entry name" value="Tim16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12388">
        <property type="entry name" value="MITOCHONDRIA ASSOCIATED GRANULOCYTE MACROPHAGE CSF SIGNALING MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12388:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03656">
        <property type="entry name" value="Pam16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3303203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="141" mass="15796" checksum="D60F106C7BF74B4F" modified="2024-07-24" version="1">MAYRYITQVVLVGTRVLGRAFAEAYKQASASSQYARAQAKSGNGSVSGRASFNTGMTLDEACKILNVKPPQNGQANMEEVMERFKRLFDNNDPKKGGSFYLQSKILRARERIEAEVKPTIEKAAQEAEVKEGWNPKLYKDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GNK9</accession>
    <name>A0AAJ0GNK9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GDS1 winged helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_486772</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719088.1">
        <property type="nucleotide sequence ID" value="XM_062866383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GNK9"/>
    <dbReference type="GeneID" id="87885212"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057511">
        <property type="entry name" value="WH_GDS1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25318">
        <property type="entry name" value="WHD_GDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GDS1 winged helix" evidence="2">
        <location>
            <begin position="116"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="229"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3303308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="423" mass="46227" checksum="F7F64E7179B286D3" modified="2024-07-24" version="1">MRPYNTRHKTLSLHSLGIHVPGTHASRTAPANRASSNDASSVSMGSPTSPAKKDESPKKRLKRAFSESSDDASPLERLPKRRDDATKFQKTTPPPSPPAAAMEMSEDEEMVTRTIDMQGINDEIVEAVITQLQNTGNRPHLVKELATVLMQQLKIVQQSANPAAIVSSRLATYLKRPGWSALSPCPLAKELESVHPRRTYFYLTTCPRKPLPDPAQLSLSTQLAHSRAIITPSPSSAASTSADESDLERRRELSPSPEVDLSSPEFDDMDDDFAMPSTPIGSFSMRGFYMPPRPAHSGSGRHGRATSPPLEKDEKEFTQTADGLQKRKLNGDLLSLSSAPMPPVEQTVSIDLERDEGSLFGGSVPPMSSFVSSPAIRPSTLSLNFGKKDAEADSWAKLEGLLEWDRSPESIELEELDGLLDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GNV9</accession>
    <name>A0AAJ0GNV9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prion-inhibition and propagation-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_560507</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719253.1">
        <property type="nucleotide sequence ID" value="XM_062870533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GNV9"/>
    <dbReference type="GeneID" id="87889362"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1020">
        <property type="entry name" value="Prion-inhibition and propagation, HeLo domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HeLo_dom"/>
    </dbReference>
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        <property type="entry name" value="HeLo_sf"/>
    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542">
        <property type="entry name" value="HELO DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542:SF1">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14479">
        <property type="entry name" value="HeLo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0034">Amyloid</keyword>
    <keyword evidence="2" id="KW-0640">Prion</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prion-inhibition and propagation HeLo" evidence="1">
        <location>
            <begin position="3"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3303473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="637" mass="72006" checksum="C75B525115EB4037" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GPD5</accession>
    <name>A0AAJ0GPD5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_540935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719449.1">
        <property type="nucleotide sequence ID" value="XM_062869819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GPD5"/>
    <dbReference type="GeneID" id="87888648"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3303669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="70" mass="7747" checksum="DBABECDAF3EB3E10" modified="2024-07-24" version="1">MVAPVWLIAIFGVRLICPQGAQSISAVAFTLLWVYVAVRSVIREGCSTRDTQVLNKLTAPLMHSCVIRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GPN6</accession>
    <name>A0AAJ0GPN6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Endosomal peripheral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_402137</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MON2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719405.1">
        <property type="nucleotide sequence ID" value="XM_062865141.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87883970"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032629">
        <property type="entry name" value="DCB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032817">
        <property type="entry name" value="Mon2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF333">
        <property type="entry name" value="PROTEIN MON2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16213">
        <property type="entry name" value="DCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16206">
        <property type="entry name" value="Mon2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Mon2/Sec7/BIG1-like dimerisation and cyclophilin-binding" evidence="8">
        <location>
            <begin position="4"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2/Sec7/BIG1-like HUS" evidence="6">
        <location>
            <begin position="210"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2 C-terminal" evidence="7">
        <location>
            <begin position="990"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="464"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="7"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3303625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1708" mass="186590" checksum="86E08EB7AE5710C1" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQ67</accession>
    <name>A0AAJ0GQ67_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">HMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_230680</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ATX1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719889.1">
        <property type="nucleotide sequence ID" value="XM_062862938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQ67"/>
    <dbReference type="GeneID" id="87881767"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000008">
        <property type="entry name" value="Copper transport protein ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051881">
        <property type="entry name" value="Copper_transport_ATOX1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46365">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46365:SF1">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="3" id="KW-0187">Copper transport</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="HMA" evidence="8">
        <location>
            <begin position="7"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3304109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="88" mass="9321" checksum="B529A0BF254527F2" modified="2024-07-24" version="1">MADAVAEHKYQFNVSMSCGGCSGAVERVLKKLEGVKSYNVSLETQTATVIADESLPYDRVLRTIAKTGKKVNSGEADGVAQSVDVPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQD3</accession>
    <name>A0AAJ0GQD3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HbrB-like-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_535802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719989.1">
        <property type="nucleotide sequence ID" value="XM_062869522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQD3"/>
    <dbReference type="GeneID" id="87888351"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013745">
        <property type="entry name" value="Bit61/PRR5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32428">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT BIT61-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32428:SF2">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT BIT61-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08539">
        <property type="entry name" value="HbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="639"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="903"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="639"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="930"/>
            <end position="946"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3304209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="946" mass="100707" checksum="4C6F28D0E6422B13" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQF3</accession>
    <name>A0AAJ0GQF3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA polymerase II holoenzyme cyclin-like subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_232481</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin C subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719976.1">
        <property type="nucleotide sequence ID" value="XM_062862964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQF3"/>
    <dbReference type="GeneID" id="87881793"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20513">
        <property type="entry name" value="CYCLIN_CCNC_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028758">
        <property type="entry name" value="Cyclin, C/H/G types"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0195">Cyclin</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="5">
        <location>
            <begin position="53"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="264"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="264"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3304196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="351" mass="38722" checksum="8FCD8EDC07421D9E" modified="2024-07-24" version="1">MAANYWESTQRKHWQFTKDELAAIRQRLDDEDPAVVQMFPLPQLRHLNIYFNQQINRLGKRLGVRQQAMATAQVYIKRFYTRVPIRQTNPYLVITTALYLACKMEECPQHIRLLSQEARSLWPSDMHGLDAPRVGECEFSLISEMQSQLIVHQPYRTLLAVQDQFALTHDEMSLAWTVINDHYMTDLPLLHPPHVVALTAVLLALVLRPSSSGAGAAGGGGSAAAAAAAANAAGGVAMAATALAQAQARAAAMAGGTPGFASQGSQSQQMVYSQGASQGEGQAAEPKKATDPRLAKVQRFAAWLAESNIDIEAMVDCTQELISFYECHEQYNDKHTREQISRFIKARSLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQP7</accession>
    <name>A0AAJ0GQP7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_231588</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719935.1">
        <property type="nucleotide sequence ID" value="XM_062862954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQP7"/>
    <dbReference type="GeneID" id="87881783"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051510">
        <property type="entry name" value="SKI8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44090:SF1">
        <property type="entry name" value="SUPERKILLER COMPLEX PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44090">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="112"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="4">
        <location>
            <begin position="176"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="200"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="245"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3304155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="335" mass="35534" checksum="27BAE5C3FEBC8B27" modified="2024-07-24" version="1">MSKQYLTAHTVDEAHPAEIFSLAPTPTSLLSASGSSALHVHSTTDPSFPLQQTIPNAHKLGCHHVCTARGGLGNVAASVGFGGEIKVWRLGPSSSEGEKRNEWQLEWELPPSKTNGGDVWAVALSADEEYLACTTSDGRIHVWEIGTREKIQTYETGARGGGSFAMAVDLSRDGRLTASGHESGAVYVFNNDAGRMVYSLSGLAKPVRAVAFSPGGKRLAAAGNAGIIALYDMEHGEHVGNLTTPSGRPAWITSLDWNDTGEYLLSGSLDGKVKVWDVARGACVATHSETESALWSVRWLPKTERALGPGMGKSEMFCAAGASRSLSFYREATGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQT1</accession>
    <name>A0AAJ0GQT1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_399398</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720151.1">
        <property type="nucleotide sequence ID" value="XM_062865004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQT1"/>
    <dbReference type="GeneID" id="87883833"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000173">
        <property type="entry name" value="Heat shock transcription factor Hsf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
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                <person name="Gladieux P."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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</entry>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
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    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720534.1">
        <property type="nucleotide sequence ID" value="XM_062869620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GRD9"/>
    <dbReference type="GeneID" id="87888449"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004015">
        <property type="term" value="F:adenosylmethionine-8-amino-7-oxononanoate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004141">
        <property type="term" value="F:dethiobiotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03109">
        <property type="entry name" value="DTBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000080">
        <property type="entry name" value="Bifunctional dethiobiotin synthetase/adenosylmethionine-8-amino-7-oxononanoate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00336">
        <property type="entry name" value="BioD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004472">
        <property type="entry name" value="DTB_synth_BioD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42684">
        <property type="entry name" value="ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42684:SF3">
        <property type="entry name" value="ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13500">
        <property type="entry name" value="AAA_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3304754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="854" mass="93038" checksum="D70E4E526E873281" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GRQ7</accession>
    <name>A0AAJ0GRQ7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_576234</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720681.1">
        <property type="nucleotide sequence ID" value="XM_062871022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GRQ7"/>
    <dbReference type="GeneID" id="87889851"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054289">
        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF2">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22942">
        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="391"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3304901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="623" mass="69275" checksum="CAD647ABEB20FC05" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GS13</accession>
    <name>A0AAJ0GS13_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_511033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720844.1">
        <property type="nucleotide sequence ID" value="XM_062867889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GS13"/>
    <dbReference type="GeneID" id="87886718"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="705"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="705"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="756"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3305064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="807" mass="89725" checksum="43A81771AAE9224B" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GS40</accession>
    <name>A0AAJ0GS40_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Aspartic peptidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_512964</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720655.1">
        <property type="nucleotide sequence ID" value="XM_062868014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GS40"/>
    <dbReference type="GeneID" id="87886843"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05474">
        <property type="entry name" value="SAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033876">
        <property type="entry name" value="SAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF65">
        <property type="entry name" value="ASPARTIC-TYPE ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042470354" evidence="7">
        <location>
            <begin position="19"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="8">
        <location>
            <begin position="77"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3304875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="459" mass="49630" checksum="D65A19515349F395" modified="2024-07-24" version="1">MSFALYAVAALLPAAVLGSGSGPFDFDFDDNRMVQQDGLIRYPVIPKTGAPLFGKHTNFTKRQVDTDSFARLSGTLYTIELTLGTPGQKVPVNFDTGSSELWVNPVCAQSTTPDFCNAQPRFTESSTLVDLGVTGGVTYGTGYADFYYVSDYVAIGSAKITQQIFGVAYDSAHAVVGIMGAGPDLLGWDSDYPLIIDSLAQQGLTNSRAFSMDLRGFASDRGSVIFGGIDTKKYKGDLVKLPIIPAAESPDGYTRFWVYVNGIRVNQPGGGVVDVYSTPAGGKGQPVLLDSGYTLSALPSPIFQKLVAAFPSAEYVPNADLYVVDCADPGQGGSLDFSFGDIVINVDYYDFVWHYPDTPYCVLGAFEDDFPVLGDTFLRAAFVVYDWDNRNIHLAQSADCGTNLVPIGSGPNAVPSIAVCDVYDFGFRVDLVNEQGDVQHRNQDRNQHRDVQLVYRHGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GTR2</accession>
    <name>A0AAJ0GTR2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_533959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721756.1">
        <property type="nucleotide sequence ID" value="XM_062869401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GTR2"/>
    <dbReference type="GeneID" id="87888230"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="213"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3305976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="311" mass="33714" checksum="32F977C6EBC6135D" modified="2024-07-24" version="1">MTSRSPSAVDPFSGLRSTSFHPHRIFGKTFGSAGIAVHQRQVINKRPICSTTIPVERPRRPKRKPKMPSFTSRHYIPDRFRSLSKADDDDDAMEDVMSTSLSPKDTASHLSSDLTLVPSDGSLLDYFDLPSPPSTPQRPTHSLSLSSLNSFSSPAIASPGRRSSAGSPPSLSSSSSPSPASSNSPRPMSSASPPRWPTAAQRIQRLPTRPRSRSASSVSSTGSSSTTMTLGGDGGGGVDVEMGGTVVPVVPLVRPARRTPYYPPNSSRNVDRTRVYMNRGPHYIPNWTPLSSLPRHVQLRIEERMVRFTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GUK1</accession>
    <name>A0AAJ0GUK1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TRIP4/RQT4 C2HC5-type zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_527006</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722124.1">
        <property type="nucleotide sequence ID" value="XM_062868941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GUK1"/>
    <dbReference type="GeneID" id="87887770"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180022">
        <property type="term" value="C:RQC-trigger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039128">
        <property type="entry name" value="TRIP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009349">
        <property type="entry name" value="TRIP4/RQT4_C2HC5_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12963:SF4">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12963">
        <property type="entry name" value="THYROID RECEPTOR INTERACTING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06221">
        <property type="entry name" value="zf-C2HC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRIP4/RQT4 C2HC5-type zinc finger" evidence="2">
        <location>
            <begin position="253"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="527"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3306344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="547" mass="58522" checksum="C585065CF8AB5D05" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GUP2</accession>
    <name>A0AAJ0GUP2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribonuclease P protein subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_141487</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic/archaeal RNase P protein component 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722251.1">
        <property type="nucleotide sequence ID" value="XM_062861884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GUP2"/>
    <dbReference type="GeneID" id="87880713"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030677">
        <property type="term" value="C:ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033204">
        <property type="term" value="F:ribonuclease P RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.210:FF:000005">
        <property type="entry name" value="Ribonuclease P protein subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.210">
        <property type="entry name" value="Ribonuclease P/MRP, subunit p29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016848">
        <property type="entry name" value="RNase_P/MRP_Rpp29-subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036980">
        <property type="entry name" value="RNase_P/MRP_Rpp29_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023534">
        <property type="entry name" value="Rof/RNase_P-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002730">
        <property type="entry name" value="Rpp29/RNP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13348:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13348">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01868">
        <property type="entry name" value="RNase_P-MRP_p29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027081">
        <property type="entry name" value="RNase_P/MRP_p29_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00538">
        <property type="entry name" value="POP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101744">
        <property type="entry name" value="Rof/RNase P subunit-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="31"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR027081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3306471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="241" mass="27122" checksum="F8EBBC3160536E3B" modified="2024-07-24" version="1">MDTKSKKDQPIAAVLLSRAHEPDEANRIFTEKIQQRPLFLTPSSPPPSDARAARRRAQEKKKQQRKKALKPKPLSATQRRKLGLYDVPRERQKYAFFEPLHQLWLGYVREILGGEIYTGGEGAAAKLASADFHGAGVEVVRSGCVSRVGIKGIVVKDSKFAFEIVTRKDRLKLVPKEGTVFRFEVPAPLPVPGSKVGEGEAQGQQLEQMSKMVFEIHGEQFQFRSADRASRKFRSHFSKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GV25</accession>
    <name>A0AAJ0GV25_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Stress response RCI peptide</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_528015</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0057 (PMP3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722483.1">
        <property type="nucleotide sequence ID" value="XM_062869008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GV25"/>
    <dbReference type="GeneID" id="87887837"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000612">
        <property type="entry name" value="PMP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659">
        <property type="entry name" value="HYDROPHOBIC PROTEIN RCI2 LOW TEMPERATURE AND SALT RESPONSIVE PROTEIN LTI6 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659:SF57">
        <property type="entry name" value="PLASMA MEMBRANE PROTEOLIPID 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01679">
        <property type="entry name" value="Pmp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="83"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3306703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="161" mass="17229" checksum="4B43001CE8EF554B" modified="2024-07-24" version="1">MCSTDIFLGLLAVLFPPLPVWVKRGICSADSFINILLFILGYIPGLLHSWYIIATYPEPPYDYDYEHLPSDVEHGRIYVFVHNGGHGQPAQPAPQGHMNYGSTNNTNKTPAGGSAAAAPHPHHPPQEQGTTSAAAGPSDGNAPPPSYAQVVAGDHKVQTHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GV50</accession>
    <name>A0AAJ0GV50_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_151370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722526.1">
        <property type="nucleotide sequence ID" value="XM_062862000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GV50"/>
    <dbReference type="GeneID" id="87880829"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3306746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="454" mass="51363" checksum="E3A334160A9B00DC" modified="2024-07-24" version="1">MPTWRSMENFLVFCMKRAAAQNCLQTKRRQPIMHTDTDGGFASFRNVWIMSWAEENIYLEHEKKHRELGHFTTLTDDPKPKEFIVRTNFADADATATATATAAEGDESLSEDDTISDSKADDSPGKRDFHWVSGILAPFPLSRAVFAIDTIEEQQRSLLERNQKLLDEYPDFSTRSLAHLGLNCIGPCRIVDNMISRLCPSSAILSSKTTALRRGEGGLYMRTRCISCQTEFDLSNALEKYDLKASSHDQICEKKCCTKPGFDGSRFCKDHLSSWRDPNPLETDFPQLQKLRENISPFLQVKWSDEPAMGKVLAFMDSIGAGKSPASALRFVNLEYNIFTGRVFEIGMCDAYGTKTMDCWTLYGSEALRAISQTSSTADCNMDRMMISSVQAHYCTQGSRTAKQVADELRRQGISQETYFIVWHLHRDDLSRLREWLESEGSMGYSPLTPSAFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GV79</accession>
    <name>A0AAJ0GV79_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secretory lipase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_153627</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722571.1">
        <property type="nucleotide sequence ID" value="XM_062862026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GV79"/>
    <dbReference type="GeneID" id="87880855"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853:SF5">
        <property type="entry name" value="LIP-DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042478837" evidence="2">
        <location>
            <begin position="17"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3306791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="448" mass="49589" checksum="296902AC07EEAC0C" modified="2024-07-24" version="1">MVFLAPFLLFWSLTSAANVIPVKEFRTLEQLVAKADAEAPRAAAYTPLPPSLDPWYRAPSTYDWTLADPGTVLKMRRAPLLNVTVGNALLAYQLLYRSTDSRYNPAWDVTTLFIPRWQARCSPSTPALCAHALLSYQLPYDTCNVDASPSFGLHLGEPYGEIADALALGWFVAVPDYEGPLASYAAGVQAGHATLDGVRAVLQVAGLFGLRLDRAKVALWGYSGGALASEWAAELSVQYAPQMKLAGVALGGLTPNVTSVTEYLNRREGAGLIPQGLMGIATQHPEAYRWIVSRLRPAFRARFLSVRRMTAAQAIRTFKYQDIYDYFVGGYRDLHTRVMQMMYNVDGYMGYHGVPTKMPLFIYNAIHDELSDIRDVDELVGRFCEVGANILYHRNTVGTHTQELVNGRGRAFAWLRSVLDGSYDSIYSSMGCTIQNVTYNLAPWVGWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GVX1</accession>
    <name>A0AAJ0GVX1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">L-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="15">1.1.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">B0T15DRAFT_566711</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(S)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:19909"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19910"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">In the C-terminal section; belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the N-terminal section; belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.3" evidence="15"/>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722896.1">
        <property type="nucleotide sequence ID" value="XM_062870705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GVX1"/>
    <dbReference type="GeneID" id="87889534"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004460">
        <property type="term" value="F:L-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006089">
        <property type="term" value="P:lactate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02922">
        <property type="entry name" value="FCB2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000062">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000012">
        <property type="entry name" value="Mitochondrial cytochrome b2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037458">
        <property type="entry name" value="L-MDH/L-LDH_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF148">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE (CYTOCHROME)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="5 17" id="KW-0349">Heme</keyword>
    <keyword evidence="10 17" id="KW-0408">Iron</keyword>
    <keyword evidence="8 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="18">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="19">
        <location>
            <begin position="104"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00061137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00066458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00068515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAK3307116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="499" mass="55375" checksum="659A109398D44871" modified="2024-07-24" version="1">MAQLTGVEVAKHNSANDCWVIVHGRAYDVTEFLPEHPGGSKIILKYAGKDATEEFDPIHPPDALEKYLPKSKHLGPVDMSTVIKEKAEESPEERERMKRIQEMPVLEQCYNLLDFEAVARRVMKKTAWGYYSSAADDEITLRENHSAFHRIWFRPRVLVDVEKVDFSTTMLGTPCSIPFYVTATALGKLGHVEGEVVLTRSAGKHNVIQMIPTLASCAFDEIMDAASPGQVQWMQLYVNKDRTITQRIVQHAEKRGCKGLFITVDAPQLGRREKDMRTKFTEQGSNVQNGQATDNSQGAARAISSFIDPSLSWDDIPWFKSITKMPIVLKGVQRVEDVIKAIEAGVQGVVLSNHGGRQLEFARSAIEVLAETMPVLRELGLENKIEIYIDGGIRRATDILKALCLGARGVGIGRPFLYAMSAYGQDGVDRAMQLLKDEMEMNMRLIGARNIGELNASMVDARSLFNHGSPPTDSLSHAVYDPLASPAQRLAVKGEKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GVZ6</accession>
    <name>A0AAJ0GVZ6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_528463</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722650.1">
        <property type="nucleotide sequence ID" value="XM_062869040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GVZ6"/>
    <dbReference type="GeneID" id="87887869"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039632">
        <property type="entry name" value="TMEM42"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31965">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31965:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3306870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="274" mass="28994" checksum="AEE5C8D80F81E484" modified="2024-07-24" version="1">MPTLRPRKRQSEAPTATTRSEGVITASASAVPSPPNIVNRKTPGSAEGEKQANTMSLPDEERPLLGGPSAEDAEVSPASSTWTKRNQWIVFALASGACAAFNGVFAKLTTTELTAGFSLAIARMLDLESIENIIELVVRGTFFGLNLAFNGVMWTLFTTALARGHSTTQVSIMNTSSNFVITAILGFVIFSEALPPLWWLGAAMLVAGNVIVGKKDEAVSMKEDELSTERAVPVSPSTDGLSTVRSGGGEQTDRVLEGHVKNEDVLDLGTEGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GW00</accession>
    <name>A0AAJ0GW00_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">4a-hydroxytetrahydrobiopterin dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.96</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">4-alpha-hydroxy-tetrahydropterin dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_529163</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin = (6R)-L-erythro-6,7-dihydrobiopterin + H2O</text>
            <dbReference type="Rhea" id="RHEA:11920"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15642"/>
            <dbReference type="ChEBI" id="CHEBI:43120"/>
            <dbReference type="EC" id="4.2.1.96"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pterin-4-alpha-carbinolamine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.96" evidence="3"/>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722874.1">
        <property type="nucleotide sequence ID" value="XM_062869090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GW00"/>
    <dbReference type="GeneID" id="87887919"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008124">
        <property type="term" value="F:4-alpha-hydroxytetrahydrobiopterin dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00488">
        <property type="entry name" value="PCD_DCoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.20">
        <property type="entry name" value="Transcriptional coactivator/pterin dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036428">
        <property type="entry name" value="PCD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001533">
        <property type="entry name" value="Pterin_deHydtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12599">
        <property type="entry name" value="PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12599:SF0">
        <property type="entry name" value="PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01329">
        <property type="entry name" value="Pterin_4a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55248">
        <property type="entry name" value="PCD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3307094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="228" mass="24952" checksum="CE3B78F956D9AFC5" modified="2024-07-24" version="1">MRPSLLLLKGGISSTAEFYSQRTTLAPVAHATYNLTPRTSLRPAHHRNRSSTFIIRHLTRFSPRNSKMNNSSSLPPRFSTGSDPAALETSLAPLLTTSGGRWTLAAEGEALEREFKFKTFAKTWDFMTAVALQCKLKNHHPEWSNVFNTTFIRWTTHHPKGLSAKDIELAAICDALAKDFGEIPIEQAQGQQQGAEQGEQSQQACGLSGLANRAVGSAGDCCVPKTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GWC1</accession>
    <name>A0AAJ0GWC1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PQ loop repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_395971</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723108.1">
        <property type="nucleotide sequence ID" value="XM_062864806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GWC1"/>
    <dbReference type="GeneID" id="87883635"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF11">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="269"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="316"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3307328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="346" mass="37748" checksum="D689E4B6E395D8C8" modified="2024-07-24" version="1">MDALLAADRCEELREVGVVNLIVSVVIVIGMLISYLPQHFRIINRRTSEGISPYFVLLGTTSATSAFANILLLPKSRQDVACCKELDSFHCVAGLLGIAQLGVQWICFTFIFVLFLVFFRYNSADDAGDNEVVDDGQPRWQTALLVASLTLLHGLAVIVVTGVLSTAAKDYLAIWANVLGVMAALLAGVQYIPQIWTTYHLKHVGSLSIPMMCIQTPGGFLFAGSLFARLGWAGWSSWGIFVLTATMQGFLLYLAIYYEIQARARGADDPKSPSPILGQSHLQANNGLDENTPGRYTSHPEIYAASPNHLQTIVDRQESDAAADTTPLLRPGGIGDPNRNYDTNRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GWJ7</accession>
    <name>A0AAJ0GWJ7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HIT-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_395014</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723199.1">
        <property type="nucleotide sequence ID" value="XM_062864761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GWJ7"/>
    <dbReference type="GeneID" id="87883590"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648:SF2">
        <property type="entry name" value="HIT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648">
        <property type="entry name" value="HIT FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="4">
        <location>
            <begin position="54"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="2 3">
        <location>
            <begin position="146"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="1">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3307419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="208" mass="22485" checksum="D48F0D8424BED514" modified="2024-07-24" version="1">MAPQTYQSSLPPIPSANFDTAVSPSDSGCPFCHISSVFAPYNPAEPPPSSSPSLNPTLTSPQPSAFIILSTPDLIAFLDIMPLSLGHVLLCPRAHRPKLTDVTPTESVELGRYLRILSAAVVKATGVGDWNVVQNNGAAAAQVVPHMHFHVIPRPELRDKGRERFTATMFGRGQRDELDEEEAAELAERVRRAVAEVVKADEQQGAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GWN0</accession>
    <name>A0AAJ0GWN0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0T15DRAFT_554345</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the xlnR/xlr1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723308.1">
        <property type="nucleotide sequence ID" value="XM_062870350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GWN0"/>
    <dbReference type="GeneID" id="87889179"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000004">
        <property type="entry name" value="Xylanolytic transcriptional activator XlnR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051439">
        <property type="entry name" value="XlnR/Xlr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47663">
        <property type="entry name" value="XYLANOLYTIC TRANSCRIPTIONAL ACTIVATOR XLNR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47663:SF1">
        <property type="entry name" value="XYLANOLYTIC TRANSCRIPTIONAL ACTIVATOR XLNR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="11">
        <location>
            <begin position="92"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="147"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="559"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="762"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="721"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="175"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="773"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3307528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="963" mass="104381" checksum="49A5A6E76F3246A7" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GXI2</accession>
    <name>A0AAJ0GXI2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">CASC3/Barentsz eIF4AIII binding-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0T15DRAFT_92550</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CASC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3307986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723766.1">
        <property type="nucleotide sequence ID" value="XM_062871460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GXI2"/>
    <dbReference type="GeneID" id="87890289"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018545">
        <property type="entry name" value="Btz_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09405">
        <property type="entry name" value="Btz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01044">
        <property type="entry name" value="Btz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="10" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Btz" evidence="14">
        <location>
            <begin position="140"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="120"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="252"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="451"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="610"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="120"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="161"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="260"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="451"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="629"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3307986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="724" mass="79403" checksum="8FBC796E2FAB0A77" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GXR9</accession>
    <name>A0AAJ0GXR9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nuclease-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_523563</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPG/RAD2 endonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723888.1">
        <property type="nucleotide sequence ID" value="XM_062868696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GXR9"/>
    <dbReference type="GeneID" id="87887525"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09902">
        <property type="entry name" value="H3TH_MKT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09858">
        <property type="entry name" value="PIN_MKT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022039">
        <property type="entry name" value="MKT1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037314">
        <property type="entry name" value="MKT1_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022040">
        <property type="entry name" value="MKT1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF32">
        <property type="entry name" value="POST-TRANSCRIPTIONAL REGULATOR MKT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12246">
        <property type="entry name" value="MKT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12247">
        <property type="entry name" value="MKT1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Post-transcriptional regulator MKT1 N-terminal" evidence="4">
        <location>
            <begin position="315"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Post-transcriptional regulator MKT1 C-terminal" evidence="3">
        <location>
            <begin position="487"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3308108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="731" mass="82538" checksum="0258E79735AC0AC2" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GY28</accession>
    <name>A0AAJ0GY28_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_392199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724024.1">
        <property type="nucleotide sequence ID" value="XM_062864618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GY28"/>
    <dbReference type="GeneID" id="87883447"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09083">
        <property type="entry name" value="EEP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF36">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="53"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3308244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="291" mass="32761" checksum="09B8EDDE095E99D1" modified="2024-07-24" version="1">MTESSHLSLPIRLITLNIRYATESPVPGEETWQIRCPRLCAQLKFLTSGHDSAFVCLQEVLHSQLTDIQERLGLSWDHTGNGREDGDRAGEYSPIFYRADRWECERSRTFWLSPTPHVPSRGWDAALKRIVTVGSFCHRDTGTVVVLMSTHLDHRGVLAREESSRLLLTLAKSWTEIADSAPHPSLFLGGDFNSTPTGKAYKILTEPGSRMSDISRLVAEDAKYGNREITYTSFGEPNSRPARIDFLFVRDAARLRFSTFGIPSNKFDDEVYLSDHRPVVADIEVPVKPAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GY53</accession>
    <name>A0AAJ0GY53_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_524147</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724103.1">
        <property type="nucleotide sequence ID" value="XM_062868744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GY53"/>
    <dbReference type="GeneID" id="87887573"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF6">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3308323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="486" mass="53559" checksum="AAEB72AD2323C24A" modified="2024-07-24" version="1">MVGVPTSKGCTLCLARSVKCDEARPSCSQCRRGRRACPGYSREMKFVDEGPKLRRRVRKTAPRAPGGTSARYSGDTSAAPIHITAVAQTGGPSLEHRSGAAVDTRAQRGFQLAWLNVSREYCYQTISAFISDIFPLGTPSAQSSFLGTWLWHVPLYLGRHPFLDAATLSLALAYFARLSRDQMVLRRAELSYGAALKSLATLVTDPRKGLGAEVLCAVLLLGHFETFVDRGHAWIRHAGGAAHLMRLRGARKCYDSAFEYSMFLSCRGAIIAEALTSREPCFLDAGEWQSVPDGLIEFPLLPSYPDLYHEIFGYFAAIPGLLKEAKSIGSDTADSTRHSVLSRATMLRDKIRQWHYRYISDTRGPTVQVLVNPPPVLDAYPFHSVYVYRDVASATMITASHAYMIALNKDCIDSIQSHSDCAEANMEMALAICMSVDYCSRSGYCGASTMKFALPIIQPVLPLKHHGWIEAWLSKFSGVVEAARVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GYG8</accession>
    <name>A0AAJ0GYG8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_523419</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723845.1">
        <property type="nucleotide sequence ID" value="XM_062868689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GYG8"/>
    <dbReference type="GeneID" id="87887518"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024512">
        <property type="entry name" value="Ser_palmitoyltrfase_ssu-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11779">
        <property type="entry name" value="SPT_ssu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3308065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="104" mass="11854" checksum="3EC606929E28EBC9" modified="2024-07-24" version="1">MASQLESFSKWLQLKIYQFEVHFSVYIFTPFEKFVIYSVLFLLISLTFIATVLYLPQHVQFIISRAWFYMHGDACDSAGELAKGVVTSVTGMAAQTAVDAMREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GYQ7</accession>
    <name>A0AAJ0GYQ7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">V-type proton ATPase catalytic subunit A</fullName>
            <ecNumber evidence="2">7.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B0T15DRAFT_110893</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Vacuole membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724342.1">
        <property type="nucleotide sequence ID" value="XM_062861500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GYQ7"/>
    <dbReference type="GeneID" id="87880329"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18111">
        <property type="entry name" value="ATP-synt_V_A-type_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01134">
        <property type="entry name" value="V_A-ATPase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000002">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000008">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000052">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1140.10:FF:000003">
        <property type="entry name" value="Vacuolar ATP synthase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="entry name" value="Bovine Mitochondrial F1-atpase, Atp Synthase Beta Chain, Chain D, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00309">
        <property type="entry name" value="ATP_synth_A_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031686">
        <property type="entry name" value="ATP-synth_a_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005725">
        <property type="entry name" value="ATPase_V1-cplx_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022878">
        <property type="entry name" value="V-ATPase_asu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003220">
        <property type="entry name" value="PRK04192.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01042">
        <property type="entry name" value="V-ATPase_V1_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607:SF1">
        <property type="entry name" value="H(+)-TRANSPORTING TWO-SECTOR ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607">
        <property type="entry name" value="V-TYPE PROTON ATPASE CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16886">
        <property type="entry name" value="ATP-synt_ab_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="16">
        <location>
            <begin position="2"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="ATPsynthase alpha/beta subunit barrel-sandwich" evidence="17">
        <location>
            <begin position="92"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="15">
        <location>
            <begin position="196"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase A/B type C-terminal" evidence="18">
        <location>
            <begin position="429"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048383"/>
        </source>
    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF22919"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3308562.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
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                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
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                <person name="Hiltunen Thoren M."/>
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            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724055.1">
        <property type="nucleotide sequence ID" value="XM_062868737.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87887566"/>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
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                <person name="Riley R."/>
                <person name="LaButti K."/>
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                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
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                <person name="Ament-Velasquez S.L."/>
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                <person name="Powell A.J."/>
                <person name="Barry K."/>
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                <person name="Grigoriev I.V."/>
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                <person name="Hiltunen Thoren M."/>
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            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
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                <person name="Ng V."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
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                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0005634">
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        <property type="match status" value="1"/>
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        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="172"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3309118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="310" mass="33087" checksum="0800000A005FE53E" modified="2024-07-24" version="1">MPPPSNNPRLPPPAEPRHSRNFDPWNSVGAGHQRAETRGPQGWRESRNLKMNSQFRAGNSGGQRISDTVGVGSADFDERLGMLVPKEVRARAMNSVADMLRNPGSMRAASRRPPPPSSSASAYRTGVPPGKGVEAEEAGTGNASRTTAEERLALARKAEDETREEEQAKRAQERRIFDGVVVYVSGSTHPLVSDHKLKHLLAEHGARMSLHLGRRQVTHVILGKPSGPSGGAGGGLAGGKLEKETRRVGGCGIKFVGVEWVLESVEAGKRLPEARFANLKIAARAQQSVLGAFSKADGSAQQPAVATPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H0I0</accession>
    <name>A0AAJ0H0I0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hydantoinase B/oxoprolinase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_526745</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxoprolinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3309269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725049.1">
        <property type="nucleotide sequence ID" value="XM_062868921.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87887750"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049517">
        <property type="entry name" value="ACX-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF26">
        <property type="entry name" value="5-OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19278">
        <property type="entry name" value="Hydant_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02538">
        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase/oxoprolinase N-terminal" evidence="5">
        <location>
            <begin position="20"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="3">
        <location>
            <begin position="255"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="Acetophenone carboxylase-like C-terminal" evidence="6">
        <location>
            <begin position="563"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase B/oxoprolinase" evidence="4">
        <location>
            <begin position="755"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1296"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1301"/>
            <end position="1311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF19278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3309269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1341" mass="145621" checksum="FCA0D75986CBD498" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H0W0</accession>
    <name>A0AAJ0H0W0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF6314 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_14228</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725566.1">
        <property type="nucleotide sequence ID" value="XM_062861888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H0W0"/>
    <dbReference type="GeneID" id="87880717"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045632">
        <property type="entry name" value="DUF6314"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19834">
        <property type="entry name" value="DUF6314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6314" evidence="5">
        <location>
            <begin position="574"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3309786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="751" mass="83076" checksum="65DD5201D6E3305D" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H0W9</accession>
    <name>A0AAJ0H0W9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_545787</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725556.1">
        <property type="nucleotide sequence ID" value="XM_062870142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H0W9"/>
    <dbReference type="GeneID" id="87888971"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3309776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="97" mass="11606" checksum="079C00FC70B2221F" modified="2024-07-24" version="1">MDDQEVKGSSDDLSTKPQDTLLLHLLRRPRHQHQHPRLRYCAGDHVHTRRLHRFEKEYSQLLHIWRDSSSLAHDDEAAEQIEIRLQELTDLLLQPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_16398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725641.1">
        <property type="nucleotide sequence ID" value="XM_062862141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H116"/>
    <dbReference type="GeneID" id="87880970"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3309861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="264" mass="30089" checksum="750F0D3CC8A74FA5" modified="2024-07-24" version="1">MYRLDRRGNTAPAQARGVLLARQLEMLDARAPLRPRMLRQDIDHHLHGRVADGMQRDLQPGLIRPLHHGSQLLRGPQRHLHMPVMRIRLRQPCRTGVHNPVTNHLDAHNPTVRRRLGIELPRQLQRPFHLLHRLLLAPQRLNQPIGSNAHRNPLLPPPYNKRLQRLPRALVHSHINHIRVLGPVVRRHSSLNGRHPLPHGRELPEIRPHIRDIGRLAKHAGQPAPCIPLAHAPGQARRPTLRRRAPQSPPCCTTSSAGPWSRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H1R7</accession>
    <name>A0AAJ0H1R7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_517684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725973.1">
        <property type="nucleotide sequence ID" value="XM_062868321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H1R7"/>
    <dbReference type="GeneID" id="87887150"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042473765" description="Secreted protein" evidence="1">
        <location>
            <begin position="32"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3310193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="88" mass="9593" checksum="31A2EEC2CFCF5836" modified="2024-07-24" version="1">MLSRCRYCVLPLLRPGLLVLALLCLSTLVTSIVNVCACTDYTFINRQSIARGVSPIRNSHKLPSRQSNTNKIACRPLGVAHADIANLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ0H1U7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDP-N-acetylglucosamine diphosphorylase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_388506</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N-acetyl-alpha-D-glucosamine 1-phosphate + UTP + H(+) = UDP-N-acetyl-alpha-D-glucosamine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="2.7.7.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.23" evidence="3"/>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726034.1">
        <property type="nucleotide sequence ID" value="XM_062864450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H1U7"/>
    <dbReference type="GeneID" id="87883279"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003977">
        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04193">
        <property type="entry name" value="UDPGlcNAc_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000075">
        <property type="entry name" value="Probable UDP-N-acetylglucosamine pyrophosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039741">
        <property type="entry name" value="UDP-sugar_pyrophosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952:SF2">
        <property type="entry name" value="LD24639P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952">
        <property type="entry name" value="UDP- GLUCOSE PYROPHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3310254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="494" mass="53635" checksum="FF5A12B6C1D25CD1" modified="2024-07-24" version="1">MAAVEAPTQQQLSELKQKYTLAGQGQVFTFYDSLSAADKASLYQQLALFDPSYINTIAAKALAPAKAEDGAAAAQPSLEPLPDSARASIMDSKPDDIDRWYSEGLDLIAANKVGVVLMAGGQGTRLGSSAPKGCFDIGLPSHKSLFQIQAERIRKVEELAAKKAGTGRSVTVPWYVMTSGPTRGPTEQYFKEHNYFGLKPENVMIFEQGVLPCISNDGKILLESKSRVAVAPDGNGGLYNALVESKVLDDMKRRGIEHIHAYCVDNCLVKVADPVFIGFSASLNVDIATKVVRKRNATESVGLILCKNGRPDVVEYSEIDPAVAAEEDPKQPGVLKFRAANIVNHYYSFRFLSTIPQWAKTLPHHVARKKIPYADLETGETVKPAKPNGIKLEQFVFDVFPMLELNKFACMEVRREDEFSPLKNARGTGEDDPDTSKHDIMAQGKRWVQAAGATVVGEDPKAGVEVSPLVSYGGEGLEKFAGKTLTAPTALEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H1W3</accession>
    <name>A0AAJ0H1W3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uracil-DNA glycosylase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_517919</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726033.1">
        <property type="nucleotide sequence ID" value="XM_062868340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H1W3"/>
    <dbReference type="GeneID" id="87887169"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008263">
        <property type="term" value="F:pyrimidine-specific mismatch base pair DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10028">
        <property type="entry name" value="UDG-F2_TDG_MUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.470.10:FF:000010">
        <property type="entry name" value="G/U mismatch-specific DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="entry name" value="Uracil-DNA glycosylase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015637">
        <property type="entry name" value="MUG/TDG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12159">
        <property type="entry name" value="G/T AND G/U MISMATCH-SPECIFIC DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12159:SF9">
        <property type="entry name" value="G_T MISMATCH-SPECIFIC THYMINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00987">
        <property type="entry name" value="UreE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="Uracil-DNA glycosylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uracil-DNA glycosylase-like" evidence="5">
        <location>
            <begin position="123"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3310253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="353" mass="37861" checksum="A2B040FEC4A052CB" modified="2024-07-24" version="1">MTTTTDTAEDGRPPPTFQGRLELDSFRFNANVTATGPRRSPRISRTPSVTAVPSARSPIPTSPSPAKRKALTVADGGSGEGDVSSPTSSSSTSKKSTTPRAKRTRQSSSYAPPSTYAHLPHLPDAIAPNLLVLFIGLNPGIQTARTGHAYAHPTNLFWRLLHSSGVTPRLVSPTEDRQMPAMYSLGLTNIVARPSRNGAELSKAEMDAGAAILEQKVRRWRPETVCVVGKSIWESLWRVRHGRAIKASEFHYGWQDEGENMGVSKDGGVLGEDEKVDGVDYGADWKGARIFVATSTSGLAATLKPKEKEDIWKGLGEWVEKRRAERAQITVTATAAPAAMATAAAIPVTLGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H331</accession>
    <name>A0AAJ0H331_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_564554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <property type="entry name" value="4'-PHOSPHOPANTETHEINE PHOSPHATASE"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
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        <location>
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            <end position="59"/>
        </location>
    </feature>
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        <location>
            <begin position="78"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3310889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="530" mass="58508" checksum="14BB6B40B1D9F4DA" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H3L5</accession>
    <name>A0AAJ0H3L5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_482296</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAK3311212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726992.1">
        <property type="nucleotide sequence ID" value="XM_062866090.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87884919"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051430">
        <property type="entry name" value="Fungal_TF_Env_Response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944:SF131">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
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        <location>
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            <end position="49"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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        </location>
    </feature>
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    </feature>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3311212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="761" mass="85376" checksum="30C058607035CACE" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H3W9</accession>
    <name>A0AAJ0H3W9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Roadblock/LAMTOR2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_72125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GAMAD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727128.1">
        <property type="nucleotide sequence ID" value="XM_062871243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H3W9"/>
    <dbReference type="GeneID" id="87890072"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10779">
        <property type="entry name" value="DYNEIN LIGHT CHAIN ROADBLOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103196">
        <property type="entry name" value="Roadblock/LC7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Roadblock/LAMTOR2" evidence="2">
        <location>
            <begin position="13"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3311348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="139" mass="14647" checksum="D31C0AAA0471898F" modified="2024-07-24" version="1">MADTISTPGPDAFEESLGRLSKKAGVRATIVLDRASGAILKTSGQVSSIRSSKTPGLSMSAAVGSFSSEASGNSANEDQGAEELASMVWRFVGTAGSLVQELDTEDEVKLLRLRTKKQEFVIVPDTKYLLVVVHDTSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H417</accession>
    <name>A0AAJ0H417_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Outer spore wall protein RRT8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_521433</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727204.1">
        <property type="nucleotide sequence ID" value="XM_062868558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H417"/>
    <dbReference type="GeneID" id="87887387"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005619">
        <property type="term" value="C:ascospore wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005628">
        <property type="term" value="C:prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059112">
        <property type="entry name" value="CysZ/EI24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052786">
        <property type="entry name" value="Spore_wall_assembly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34292">
        <property type="entry name" value="OUTER SPORE WALL PROTEIN LDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34292:SF2">
        <property type="entry name" value="OUTER SPORE WALL PROTEIN LDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07264">
        <property type="entry name" value="EI24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3311424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="31713" checksum="36CE276E1463C716" modified="2024-07-24" version="1">MANNIADRAQEIAKEDLGRAKVLLNEAARSQSYLYPIKGIIYFFTHPGLWKPLRSKLIPYLTLYSGVLGSMFFFTYLPQVAILTFVNGPLAIFTTVLLVLNESATITSLISKNYLLQDALLDTFDGTLMTRNKANVVAEGRELKSQGDLIQRLGKVLKKPFGRFSVNELIRYFMYLPLNFIPVVGTVAFILLRGRSRGDSAHERYFQLKAWSTSRKSEWLKTHKAPYTAFGTVATLLEMIPLASILFSFTNTVGAALWAADIEAGESEMAKGTAPGLREAAKKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H423</accession>
    <name>A0AAJ0H423_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_65369</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726954.1">
        <property type="nucleotide sequence ID" value="XM_062871153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H423"/>
    <dbReference type="GeneID" id="87889982"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF92">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="3">
        <location>
            <begin position="731"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="89"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="424"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="500"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="869"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="504"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="516"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="880"/>
            <end position="891"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3311174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1025" mass="112915" checksum="4A7D8845714AF95D" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H452</accession>
    <name>A0AAJ0H452_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Importin-95</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Karyopherin-95</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_73526</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family. Importin beta-1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727177.1">
        <property type="nucleotide sequence ID" value="XM_062871263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H452"/>
    <dbReference type="GeneID" id="87890092"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000027">
        <property type="entry name" value="Importin subunit beta-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="9">
        <location>
            <begin position="25"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00079884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00083566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3311397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="877" mass="95739" checksum="9C2530B02FF40325" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H580</accession>
    <name>A0AAJ0H580_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">VIT family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_565207</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CCC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727495.1">
        <property type="nucleotide sequence ID" value="XM_062870662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H580"/>
    <dbReference type="GeneID" id="87889491"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008217">
        <property type="entry name" value="Ccc1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31851">
        <property type="entry name" value="FE(2+)/MN(2+) TRANSPORTER PCL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01988">
        <property type="entry name" value="VIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3311715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="257" mass="27362" checksum="EF1CCC084CC6FCD0" modified="2024-07-24" version="1">MSRVWRPLLDTLGLQPQVQVPPPAQPPSPSPPGTGEVSSQLFQRPTLSRFLADFTLGFADGLTVPFALTAGLSSLGHTDTVIYAGMAEICAGSISMGIGGYLSARGEVAAAAAADKAGAEAVVEGLRETQRRGDRQRDEEGENRDERLPSPLMAGFSVALGYLLGGVLPLFPYFFVRHVKDGLSWSFGVCAVALFLFGFCKDFALSGKPRRMRGSDIRRSAWEGAQMVFLGSVAALAAVLCVRAFEGIQVDHSEQSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LXU1</accession>
    <name>A0AAJ0LXU1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH:ubiquinone oxidoreductase-like 20kDa subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_423514</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the complex I 20 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717492.1">
        <property type="nucleotide sequence ID" value="XM_062865592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LXU1"/>
    <dbReference type="GeneID" id="87884421"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12280:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit B 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01356">
        <property type="entry name" value="NDH1_NuoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006138">
        <property type="entry name" value="NADH_UQ_OxRdtase_20Kd_su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01957">
        <property type="entry name" value="nuoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005012">
        <property type="entry name" value="PRK06411.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11995">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11995:SF14">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56770">
        <property type="entry name" value="HydA/Nqo6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01150">
        <property type="entry name" value="COMPLEX1_20K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase-like 20kDa subunit" evidence="5">
        <location>
            <begin position="94"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="27"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3301712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="219" mass="24327" checksum="16811C03D95EF725" modified="2024-07-24" version="1" fragment="single">MRSPTALIRCTSLARSVQPPAVSAVLARPYSSERPSASPSTRRPPLPARPPRATALSTEKKPTAVAEYILTTLDALINWGRQSSLWPLSFATACCGIEMMHASMPRYDNDRQGIIFRASPRQADVLIVAGTVTNKMASAVRLCYDQMPDPKWVISMGTCANGGGYYHYSYSVVRGVDRLIPVDVYVPGCPPTAEALLYGIFQLQRKMRRTKVTRMWYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LXX7</accession>
    <name>A0AAJ0LXX7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_321502</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717478.1">
        <property type="nucleotide sequence ID" value="XM_062864058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LXX7"/>
    <dbReference type="GeneID" id="87882887"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009403">
        <property type="term" value="P:toxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000047">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF210">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ASQL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3301698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="505" mass="58374" checksum="DB1E369DA8AB9026" modified="2024-07-24" version="1">MATHSAFLGNSHFVGPTVLAAALGAVVLFLYLLARSVYYAFVHPLAKVPGPKLYACSDLPYLYHSLRGDWQFKLKQLHDRYGPVLRYTPDNVSFTTPGAWKTIYGHRAAGQKTFVKDRITYRPTLSGHPHIVVANAEDHRRQRRLLSHAFSEKALRGQEDIMKHYIDLLIRRLGERAATGESVNMVQWYNFTTFDLIGDLAFGEPFGCLERGVYHPWVAMIFQNIKSTLYGEVMRRYPRLKPLVTLLTPKQLLRSQREHWELSEQTARRRLESGNVSREDFMSYILRHNDEKGMSQGEIIENAQVLIFAGSETTATQLSGTTFLLLRNRDKYEKLVKEVRSSFASDDEITLLRVSRLEYMNAVFEEGFRMYPPVPLALSRRTPPKGEFIEGYWMPGDTAVGVPQWAAYQSERNFRNHDQFVPERWLGDPDYAQDVRDVLQPFSVGPRNCIGKNLAYAEMRLILARVLWNFDLELMNESWNWNDQKIYLLWEKGPLMVKLTPVSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LYM7</accession>
    <name>A0AAJ0LYM7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(+) diphosphatase</fullName>
            <ecNumber evidence="4">3.6.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_440810</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60876"/>
            <dbReference type="Rhea" id="RHEA-COMP:15698"/>
            <dbReference type="Rhea" id="RHEA-COMP:15719"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:144029"/>
            <dbReference type="ChEBI" id="CHEBI:144051"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:60877"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family. NudC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.22" evidence="4"/>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718213.1">
        <property type="nucleotide sequence ID" value="XM_062865909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LYM7"/>
    <dbReference type="GeneID" id="87884738"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006742">
        <property type="term" value="P:NADP+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03429">
        <property type="entry name" value="NUDIX_NADH_pyrophosphatase_Nudt13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000042">
        <property type="entry name" value="Probable NADH pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050241">
        <property type="entry name" value="NAD-cap_RNA_hydrolase_NudC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015375">
        <property type="entry name" value="NADH_PPase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049734">
        <property type="entry name" value="NudC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015376">
        <property type="entry name" value="Znr_NADH_PPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42904:SF6">
        <property type="entry name" value="NAD-CAPPED RNA HYDROLASE NUDT12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42904">
        <property type="entry name" value="NUDIX HYDROLASE, NUDC SUBFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09296">
        <property type="entry name" value="NUDIX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09297">
        <property type="entry name" value="Zn_ribbon_NUD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="10">
        <location>
            <begin position="263"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3302433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="425" mass="46450" checksum="D86119ACDB64F8F7" modified="2024-07-24" version="1">MPTPDLPTLTFADSEETSLLSRKFGREIANYFSGSPLNRLSFLRADHDFLRAAFAHSRARFLLLNALAPLVQAADTAQLAFATHADVVALTGPAESGGPFSRTEEEMVAQYDSSEERVIVVFLGVDETSILDATTTQKEEVEEFRYRDFKGTPYFAVDVTPRGKLAGAAEGVINAMKEKGFAFHDHSPRHMGLHAGQAAIYGHARALVDWNTRTPFCAQCGQPTLSVQAGTKRVCPPTDRAGGQVRERKPCATRGTVSNHSFPRTDPTVIMAVISADGTKVLLGRQRRWPKYWFSTLAGFQEPGESIEEAVRREVWEESGVKVGRVVLHSSQPWPFPASLMIGAIGQALPGDGEKIYLGHDAELESAKWFPLEEVKEALEKGASGLGEAAPDGYVEGALRLPPQTAIANRLMTAVVEGWWIPSRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZ35</accession>
    <name>A0AAJ0LZ35_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RTA1 like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_261703</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718812.1">
        <property type="nucleotide sequence ID" value="XM_062863343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZ35"/>
    <dbReference type="GeneID" id="87882172"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF8">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14140)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="307"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3303032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="333" mass="36087" checksum="2CF80CCB84544ED1" modified="2024-07-24" version="1">MSTNSLPKGYRPSYAVCHEVSPICPVKATTLGYYPNEGLNIFFTIGFGLAALIALSLGVWKRTWGFTIAIVAGTILECVGYVGRTLLATNPWNDGAFRMQIVAIILGPTLVCIGLYLTLKHAVNALNRSLSRVKPRVYPLFFVPADVSCLVIQAIGGGIAASAGGDNYALLQHGNRTIMAGIVLQVVVLGFFGAMAADYLVRVGRYFRGSGGGNNNVAPEHQAGAALWADKKFRAFLWAMALAYVALLIRCIYRIAEMAGGWGNHIMQDEPSFVVLESFMVLIACLLLAVFAPGIFFPQMSHSFRRAAGEQEEEEKRPQTESDEAGLEMGERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZK2</accession>
    <name>A0AAJ0LZK2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Riboflavin kinase</fullName>
            <ecNumber evidence="4">2.7.1.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Flavin mononucleotide kinase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0T15DRAFT_276450</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) coenzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>riboflavin + ATP = FMN + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14357"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the flavokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.26" evidence="4"/>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719265.1">
        <property type="nucleotide sequence ID" value="XM_062863524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZK2"/>
    <dbReference type="GeneID" id="87882353"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008531">
        <property type="term" value="F:riboflavin kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009398">
        <property type="term" value="P:FMN biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.30">
        <property type="entry name" value="Riboflavin kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023468">
        <property type="entry name" value="Riboflavin_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015865">
        <property type="entry name" value="Riboflavin_kinase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023465">
        <property type="entry name" value="Riboflavin_kinase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749:SF6">
        <property type="entry name" value="RIBOFLAVIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749">
        <property type="entry name" value="RIBOFLAVIN KINASE/FMN ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01687">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00904">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82114">
        <property type="entry name" value="Riboflavin kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="10 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Riboflavin kinase" evidence="15">
        <location>
            <begin position="17"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3303485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="228" mass="24987" checksum="61DF6C11D980AA3C" modified="2024-07-24" version="1">MATPNRPSLIGDPSGPSPPYPLHMSGRVISGFGRGSKELGIPTANLPVDDASTPWISTTPSGVYFGWASLNLPPTHPDYILPTVNVDNNNNNKRRAAANANGFAVYPMVMSIGYNPFYKNTVRSAEVHVLHSFRADFYGAEMRLLITGFIREERDYSGLEALIADINFDCDVAKRSLAREAWAPREVDVEVDVPGEEGRKVVLRGQLEAAWLIRPSESGRTGQRSVVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZT5</accession>
    <name>A0AAJ0LZT5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">chitinase</fullName>
            <ecNumber evidence="4">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0T15DRAFT_402376</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="4"/>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719519.1">
        <property type="nucleotide sequence ID" value="XM_062865159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZT5"/>
    <dbReference type="GeneID" id="87883988"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02878">
        <property type="entry name" value="GH18_zymocin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053214">
        <property type="entry name" value="LysM12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47700:SF2">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47700">
        <property type="entry name" value="V CHITINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13720)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="6" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="11 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 13 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="LysM" evidence="14">
        <location>
            <begin position="6"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="15">
        <location>
            <begin position="167"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3303739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="504" mass="55183" checksum="03B3D310B0E9BFB5" modified="2024-07-24" version="1">MGQACSYTQVAAGDGCWSLAQRCGITQDQFVQYNGADICSKLQPRQYVCCSEGVLPDLPLPSKLMVGNNICLSTGSPPMPAPLDKASCGPQVPGTPRPANMDDLANLNPCPLNACCNVWGQCSIDENFCIPSPVPGGAPGTATPGSNECIANCGLDIIGNDSPPAEYKRIGYWEGWNADRPCLNMRAGNIDTKRYTHIHFAFGNKTADYHVDVSGLQSAYNDFKALAGVKRIMSFGGWTFSTDYDTYPIFREGVTPEQRYAFAQNVVNFIVNEGLDGVDFDWEYPGAPDIPDIPPASKQNGENYLDFLRNVRQLLPSHLTIGIAAPASFWYLKGFPLAEIAKVVDYIVYMTYDLHGQWDYDNQWTSPGCPKGDCLRSHVNRTETELALVMATKAGAPAHKIIVGMPMYDRSFKMAQPDCWGPDCHFTGPESGAAKGRCTGTSGYISNFEIREIIATNPNIEMHTDDNGDILVYNGDQWVSWLSKSSYEARENWIKGLNFGGASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M032</accession>
    <name>A0AAJ0M032_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein-tyrosine-phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_512243</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719820.1">
        <property type="nucleotide sequence ID" value="XM_062867966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M032"/>
    <dbReference type="GeneID" id="87886795"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033260">
        <property type="term" value="P:nuclear DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000110">
        <property type="entry name" value="PPS1p Protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053239">
        <property type="entry name" value="Dual_spec_PTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47550">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE PPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47550:SF1">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE PPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="4">
        <location>
            <begin position="539"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="5">
        <location>
            <begin position="607"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="395"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="48"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="409"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3304040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="721" mass="80168" checksum="6D15A8DF285DCE7D" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M072</accession>
    <name>A0AAJ0M072_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Phosphatidic acid phosphatase type 2/haloperoxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_535678</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the type 2 lipid phosphate phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719940.1">
        <property type="nucleotide sequence ID" value="XM_062869511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M072"/>
    <dbReference type="GeneID" id="87888340"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042392">
        <property type="term" value="F:sphingosine-1-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03388">
        <property type="entry name" value="PAP2_SPPase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969:SF28">
        <property type="entry name" value="DIHYDROSPHINGOSINE 1-PHOSPHATE PHOSPHATASE LCB3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="10">
        <location>
            <begin position="115"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3304160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="576" mass="62724" checksum="52B30A3E2EFEB01D" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M0F7</accession>
    <name>A0AAJ0M0F7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_240917</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720192.1">
        <property type="nucleotide sequence ID" value="XM_062863062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M0F7"/>
    <dbReference type="GeneID" id="87881891"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016652">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19120">
        <property type="entry name" value="AKR_AKR3C2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044494">
        <property type="entry name" value="AKR3C2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="7">
        <location>
            <begin position="40"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="6">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3304412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="315" mass="35110" checksum="9B6658BD77D56D1B" modified="2024-07-24" version="1">MNSEAAEYKPNASGTAPKQLEYIPHLKLSDGNEIPMLGYGLGTANYKRGANRDKFDEKIVNNAVTAIKSGYYHLDGAEVYGNEPELGAAISRSGVPRSKLFITTKTSCRPGDSIEAAFSRSLAKLRVDYVDLYLIHSPFWAGSPAELQQKWAEMEALKDSGRARSIGVSNYLREHLEAVLATAKHPPVVNQIEYHPYLQHEGGLVDFCREKGIAVEAYAPLSAVTRAAPGPVDAVYERVAKKYGVTTGEVALRWCLDQGIVTLTTSSNEERLKEWMQRLPLFKLTPTEVEEIATKGREKHYRAFWMEKFAQGDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M0X4</accession>
    <name>A0AAJ0M0X4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_537686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720598.1">
        <property type="nucleotide sequence ID" value="XM_062869638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M0X4"/>
    <dbReference type="GeneID" id="87888467"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042594825" evidence="1">
        <location>
            <begin position="23"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3304818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
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        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ0M157_9PEZI</name>
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    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Calhoun S."/>
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                <person name="Kuo A."/>
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                <person name="Riley R."/>
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                <person name="Andreopoulos B."/>
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                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
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                <person name="Grigoriev I.V."/>
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                <person name="Hiltunen Thoren M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Andreopoulos B."/>
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                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
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                <person name="Hiltunen Thoren M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721662.1">
        <property type="nucleotide sequence ID" value="XM_062862700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M1V7"/>
    <dbReference type="GeneID" id="87881529"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3305882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="201" mass="23687" checksum="703E73F86493394A" modified="2024-07-24" version="1">MLWVEGFNKVSLFIKPQQQPGTCDGRKEDIAEGNYLINQASLHVQRAKQSGEMPIIMPAILIHRHAWQAWQQGQRTHRSDNRPPRSRQSRTTLLRSSVQEFSYPFDISFPEQISIMIISVPVHCSQHRVRRPIVVGWEPSRKHERERGERMRRGLRPHRNDPYDQTTRRHYYQPPRLEPWPSLADVFDVSEAVPVLSLIWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M1Y6</accession>
    <name>A0AAJ0M1Y6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">T-complex protein 1 subunit eta</fullName>
            <shortName evidence="9">TCP-1-eta</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">CCT-eta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_511886</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterooligomeric complex that forms two stacked rings.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3306031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721811.1">
        <property type="nucleotide sequence ID" value="XM_062867944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M1Y6"/>
    <dbReference type="GeneID" id="87886773"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03340">
        <property type="entry name" value="TCP1_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000022">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000006">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012720">
        <property type="entry name" value="Chap_CCT_eta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02345">
        <property type="entry name" value="chap_CCT_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="526"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="547"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3306031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="557" mass="60751" checksum="10D76B4CC48258B9" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M2F7</accession>
    <name>A0AAJ0M2F7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Translation machinery-associated protein 20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_141440</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in translation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TMA20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722248.1">
        <property type="nucleotide sequence ID" value="XM_062861883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M2F7"/>
    <dbReference type="GeneID" id="87880712"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11609">
        <property type="entry name" value="MCT1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21155">
        <property type="entry name" value="PUA_MCTS-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016437">
        <property type="entry name" value="MCT-1/Tma20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041366">
        <property type="entry name" value="Pre-PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22798:SF0">
        <property type="entry name" value="MALIGNANT T-CELL-AMPLIFIED SEQUENCE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22798">
        <property type="entry name" value="MCT-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17832">
        <property type="entry name" value="Pre-PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005067">
        <property type="entry name" value="Tma_RNA-bind_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PUA" evidence="5">
        <location>
            <begin position="93"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="117"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR005067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3306468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="228" mass="25179" checksum="D4A8F7D31F54832C" modified="2024-07-24" version="1">MFKKDLNASPKQRQKLKSSIQRSIRQSLLNTYPLLTPVIDEVLPKKSSLEQVKLPDRVLLYLIDNHPVFYQQDSDGVLLPHLRLVHRFPQCFPTIRIDRGAIRFVLSGATLMAPGLTSKGGRLPIPVDRGAATGEEKKDAQKEGEEGGEAGEDDGEAKTPDEGPDEDGHWSRELEKGEPVVIMAEGKEEACAVGVLTMGTKEIKEKGKGPAMEETHYLGDGLWRLSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M2I3</accession>
    <name>A0AAJ0M2I3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sodium/hydrogen exchanger family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_430915</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722129.1">
        <property type="nucleotide sequence ID" value="XM_062865727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M2I3"/>
    <dbReference type="GeneID" id="87884556"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43562">
        <property type="entry name" value="NAPA-TYPE SODIUM/HYDROGEN ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43562:SF2">
        <property type="entry name" value="SODIUM-HYDROGEN ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0050">Antiport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="297"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="378"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="407"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="451"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="489"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="9">
        <location>
            <begin position="29"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="9">
        <location>
            <begin position="195"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3306349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="532" mass="56452" checksum="29B38CCFCE37383F" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M3Q3</accession>
    <name>A0AAJ0M3Q3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 17">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="2 17">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">B0T15DRAFT_87354</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="17">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14 17">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="2 17"/>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3307877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723657.1">
        <property type="nucleotide sequence ID" value="XM_062871410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M3Q3"/>
    <dbReference type="GeneID" id="87890239"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07857">
        <property type="entry name" value="STKc_MPK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000013">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000157">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008350">
        <property type="entry name" value="MAPK_ERK3/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01771">
        <property type="entry name" value="ERK3ERK4MAPK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7 17 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 15 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 16" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="23"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="363"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="370"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAK3307877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="413" mass="46602" checksum="CDF6715D9867BDCE" modified="2024-07-24" version="1">MADLQGRKIFKVFNQDFIVDERYTVTKELGQGAYGIVCAAVNNQTNEGVAIKKVTNVFSKKILAKRALREIKLLQHFRGHRNITCLYDMDIPRPDNFNETYLYEELMECDLAAIIRSGQPLTDAHFQSFIYQILCGLKYIHSANVLHRDLKPGNLLVNADCELKICDFGLARGFSIDPEENAGYMTEYVATRWYRAPEIMLSFQNYTKAIDVWSVGCILAELLGGRPFFKGRDYVDQLNQILHILGTPNEETLSRIGSPRAQEYVRNLPYMAKKSFPSLFPNANPDALDLLDRMLAFDPSRRISVEAALEHPYLAIWHDASDEPDCPATFNFDFEVIEDVNEMRKMILDEVFRFRQLVRTAPGSGGHGAPGQQPVAAPVPLPANGAPHQWTAEDPRPQEYGAVQGLEAELGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M3V7</accession>
    <name>A0AAJ0M3V7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_96138</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723855.1">
        <property type="nucleotide sequence ID" value="XM_062871494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M3V7"/>
    <dbReference type="GeneID" id="87890323"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14137">
        <property type="entry name" value="STKc_GSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000055">
        <property type="entry name" value="Glycogen synthase kinase-3 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000009">
        <property type="entry name" value="Glycogen synthase kinase-3 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050591">
        <property type="entry name" value="GSK-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039192">
        <property type="entry name" value="STKc_GSK3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057">
        <property type="entry name" value="GLYCOGEN SYNTHASE KINASE-3 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057:SF0">
        <property type="entry name" value="PROTEIN KINASE SHAGGY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="35"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3308075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="394" mass="45181" checksum="79A18A7F3C6885C3" modified="2024-07-24" version="1">MSSNRPAAFNTLRMGEVIREKVQDGVTGETREIQYTQCKIVGNGSFGVVFQTKLSPSNEDAAIKRVLQDKRFKNRELQIMRIVRHPNIVQLKAFYYSNGERKDEVYLNLVQEFVPETVYRASRFFNKMKTTMPMLEVKLYIYQLFRALAYIHSQGICHRDIKPQNLLLDPSTGVLKLCDFGSAKILVENEPNVSYICSRYYRAPELIFGATNYTTKIDVWSTGCVMAELMLGQPLFPGESGIDQLVEIIKVLGTPTREQIRTMNPNYMEHKFPQIKPHPFNKVFRKADANAIDLIARLLEYTPTERLGAIDAMVHPFFDELRDPNTKLPDSRHGTGTLRDLPPLFDFSRHELSINPQLNHQLVPPHMVPVLAARGLDIDDFTPMNKQEMMAKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M3Z2</accession>
    <name>A0AAJ0M3Z2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Dak1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0T15DRAFT_99147</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-glyceraldehyde + ATP = D-glyceraldehyde 3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13941"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.28"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>dihydroxyacetone + ATP = dihydroxyacetone phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15773"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.29"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Polyol metabolism; glycerol fermentation; glycerone phosphate from glycerol (oxidative route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dihydroxyacetone kinase (DAK) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723927.1">
        <property type="nucleotide sequence ID" value="XM_062871522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M3Z2"/>
    <dbReference type="GeneID" id="87890351"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050354">
        <property type="term" value="F:triokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10440:FF:000002">
        <property type="entry name" value="Dihydroxyacetone kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.340:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1180.20:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10440">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.20">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012734">
        <property type="entry name" value="DhaK_ATP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004006">
        <property type="entry name" value="DhaK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050861">
        <property type="entry name" value="Dihydroxyacetone_Kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02361">
        <property type="entry name" value="dak_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629:SF14">
        <property type="entry name" value="DIHYDROXYACETONE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629">
        <property type="entry name" value="TRIOKINASE/FMN CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02733">
        <property type="entry name" value="Dak1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82549">
        <property type="entry name" value="DAK1/DegV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="DhaL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51481">
        <property type="entry name" value="DHAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaK" evidence="15">
        <location>
            <begin position="9"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="DhaL" evidence="14">
        <location>
            <begin position="390"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-hemiaminal-histidine intermediate" evidence="11">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="57"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR612734-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR612734-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3308147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="597" mass="62377" checksum="E86054376D6DCAEA" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M4B2</accession>
    <name>A0AAJ0M4B2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B0T15DRAFT_524581</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724288.1">
        <property type="nucleotide sequence ID" value="XM_062868779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M4B2"/>
    <dbReference type="GeneID" id="87887608"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF17">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042504421" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="17">
        <location>
            <begin position="19"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="18">
        <location>
            <begin position="19"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAK3308508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="255" mass="27644" checksum="74580F479D788075" modified="2024-07-24" version="1">MLLRTTALALALAGTVSAHATMFGVFVNGKDQGDGRNKYIRSPATNDPLRDLKDPNIVCNTNGGKPAPEFVKASAGDKLSFRWFHFNPDDPNDILDPSHKGAILTYIAPYTEGNGAGPIWSKLAEQGFENGKWATIKMIANGGKVDFSLPAQLAPGKYLVRQELVALHQADFRGDTNPGRGAELYPSCVQVEVTGGNGEALPDQDFDFNRGYTYDNPGLFFNIYIPFDKYTPPGPKVWDPAGTVKPDKSPSGNRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M4E2</accession>
    <name>A0AAJ0M4E2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0T15DRAFT_114390</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endomembrane system</location>
            <topology evidence="11">Lipid-anchor</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the small GTPase superfamily. Rheb family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724437.1">
        <property type="nucleotide sequence ID" value="XM_062861540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M4E2"/>
    <dbReference type="GeneID" id="87880369"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04137">
        <property type="entry name" value="RheB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000273">
        <property type="entry name" value="GTP-binding protein Rheb homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3308657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="188" mass="20884" checksum="857521A40136D182" modified="2024-07-24" version="1">MPSTLAKQRKIAIVGSRSVGKSSLAVRYVDGHFVESYYPTIENTFSKEIRYKGQEYATEIVDTAGQDEYSILNSKHFIGIHGYMLVYSVSSLPSFEMVQVIRDKILNHLGTDSVPICIVGNKCDLRPEQRQVTPEEGKALADKYHCAWTEASARYNENVAKAFELLIGEVEKSQNPSEPSGGGKCVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M4F6</accession>
    <name>A0AAJ0M4F6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="7">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_508925</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="7">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="7"/>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724244.1">
        <property type="nucleotide sequence ID" value="XM_062867757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M4F6"/>
    <dbReference type="GeneID" id="87886586"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="42"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="256"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="495"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="536"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="569"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3308464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="578" mass="61821" checksum="65DEA65FA514C26E" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M4K4</accession>
    <name>A0AAJ0M4K4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_524813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724394.1">
        <property type="nucleotide sequence ID" value="XM_062868803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M4K4"/>
    <dbReference type="GeneID" id="87887632"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="340"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3308614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="430" mass="46446" checksum="F3D4377DB20B69CD" modified="2024-07-24" version="1">MSLASRPLATGEASYPIDMTNTEALDDSTEFPLTSRSGAFDEPIFDKFYEADNQHTMQHTMAPSPKRLRSSDDAPELPPRSALRASKMLDNHGLELGVAVEAPELSQTPTPHDVYLSSEEDASSDAGDVSDFDYDSSVEDPTSPTRRSSHEDMARVVSVVFAGKPSIVDLAATRKRPVSSSSQGTARSRASSASSGKPTASTLDSIQERPVTPASTTSSQYSQPRPTPSRRSSLLSEILIKKKPPFLSIDPYANGSSYALDMPKALDSLEGENSSARTPRTPTALLKGVTRSFSLVRRRSRPNLSSPLTPVPRLDTAFTSNPNRASVQLPALALLPEEQQQQFKAEGEQQQQHDQARKLEQQPRTPMTPITYTDILKAVKRNATMMGAASPPSDILSPTSPNGPAATTTRRGILSGLSARRRSVKLTGKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M4W7</accession>
    <name>A0AAJ0M4W7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_491503</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
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                <person name="Hensen N."/>
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                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
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                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
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                <person name="Powell A.J."/>
                <person name="Barry K."/>
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                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
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        </source>
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        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
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                <person name="Chen C."/>
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                <person name="Steindorff A."/>
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                <person name="Grigoriev I.V."/>
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                <person name="Gladieux P."/>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
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                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </source>
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        </source>
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        <source>
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        </source>
    </evidence>
    <sequence length="404" mass="44301" checksum="6D05E8EC3D765AEE" modified="2024-07-24" version="1">MVTFPGIEYRWHTSCMTEDQKYQGALYRDKKSNTKPAPAATSSSHPVPNAMVQAAYVEDVAEDQNSWRDYEQRSDDDDRSPVDLLPEAPTPPSAVDAEGNVNVFDFLVANPTPTASQVNLPATAPIQLSEDTQLVRFDPEANGMGDSLGDDCAMVQYGNGPVPAHFDTPAPKAARKKAKDGDKETKKGKKRKGLHIETDHIMTDAPPVLHSGLTGGIDRLMSRHTVFPPSPDYSGVDVAETPASPLKKTKSKHPKSSRPAEAISNSLMAMISAGSKPKPSSKKRTKTKPSSSPSKPKKKHSTKSLEAPKEPKLLEFRPESKDGKGENGTLVVYKPRAEHFLSFVNKGPESARGCSLNKALKRYHRERSASGTALNKLTEEKELFRSLRMKRNERGEIVLFCIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M5D3</accession>
    <name>A0AAJ0M5D3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">D-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="6">1.1.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_4761</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(R)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13521"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.4" evidence="6"/>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725294.1">
        <property type="nucleotide sequence ID" value="XM_062865994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M5D3"/>
    <dbReference type="GeneID" id="87884823"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008720">
        <property type="term" value="F:D-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903457">
        <property type="term" value="P:lactate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000014">
        <property type="entry name" value="D-lactate dehydrogenase (Cytochrome), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.45.10:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2740:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748:SF116">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE (CYTOCHROME) (AFU_ORTHOLOGUE AFUA_7G02560)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="10">
        <location>
            <begin position="174"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3309514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="606" mass="66290" checksum="ED44373CB5397740" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M5F1</accession>
    <name>A0AAJ0M5F1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0T15DRAFT_424727</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725561.1">
        <property type="nucleotide sequence ID" value="XM_062865619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M5F1"/>
    <dbReference type="GeneID" id="87884448"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF5">
        <property type="entry name" value="RE44586P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
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        </source>
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        </source>
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        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3309781.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
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    <sequence length="884" mass="99490" checksum="865E9073E3798399" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ0M5Q6_9PEZI</name>
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            <fullName evidence="4">RRM domain-containing protein</fullName>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
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    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
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                <person name="Cros-Aarteil S."/>
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
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                <person name="Chen C."/>
                <person name="Yanf M."/>
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                <person name="Clum A."/>
                <person name="Steindorff A."/>
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                <person name="Martin F."/>
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                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21245">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN"/>
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    </dbReference>
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    </feature>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ0M612_9PEZI</name>
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        <submittedName>
            <fullName evidence="3">TRAPP trafficking subunit Trs65-domain-containing protein</fullName>
        </submittedName>
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    </gene>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
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                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726176.1">
        <property type="nucleotide sequence ID" value="XM_062864175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M612"/>
    <dbReference type="GeneID" id="87883004"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055420">
        <property type="entry name" value="IgD3_Trs65"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024662">
        <property type="entry name" value="Trs65"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28159">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX II-SPECIFIC SUBUNIT 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28159:SF1">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX II-SPECIFIC SUBUNIT 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12735">
        <property type="entry name" value="IgD3_Trs65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trafficking protein particle complex II-specific subunit 65 IgD3" evidence="2">
        <location>
            <begin position="418"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3310396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="618" mass="66858" checksum="00E88C5D503704B1" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M664</accession>
    <name>A0AAJ0M664_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">CCCH zinc finger and SMR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_42109</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726341.1">
        <property type="nucleotide sequence ID" value="XM_062865550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M664"/>
    <dbReference type="GeneID" id="87884379"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.110:FF:000002">
        <property type="entry name" value="CCCH zinc finger and SMR domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013899">
        <property type="entry name" value="DUF1771"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045124">
        <property type="entry name" value="Su(sable)-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13119:SF12">
        <property type="entry name" value="PROTEIN SUPPRESSOR OF SABLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13119">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08590">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01162">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Smr" evidence="8">
        <location>
            <begin position="596"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="57"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="375"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="468"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="718"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="438"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="474"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="718"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3310561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="737" mass="79989" checksum="9AD9CEE628C7D7C8" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M6X3</accession>
    <name>A0AAJ0M6X3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_482185</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726837.1">
        <property type="nucleotide sequence ID" value="XM_062866082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M6X3"/>
    <dbReference type="GeneID" id="87884911"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF46">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G11830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="362"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="433"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="15"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3311057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="506" mass="55554" checksum="E828E045D84FF5B7" modified="2024-07-24" version="1">MGLTFGSTRVFNWYISLVAAACMVLYGYDASVYNSVQGSKNWVAYFGDPDPNMIGAINTAYTVGAIFGGFFLGGPVADYLGRKVGMASGCILVIAATFMQTFSPRHNIACFLAGRCIIGIGQGVALTAGPIYIGELAPPEIRGKIMTFWQTFYSVGSFICFWVNYGCTQHKEKLGEWDWKMVVMFQLLVPALILCLLPTIPGSPRWFIQRGNNIEKARAALLKVRETPEEVDEELLRIREAIEYEKEAISGSYSALWKDKSLRKRLLLCSILNAGQQLTGQGSLNTYSTKIYQKVFTSSGQIALINALNATFGIIFTLNAIWIIDRFGRKILLMAGGLGMAICMVIAAAVETETPSPGGGKSVSVGISIVFLLFLFIFFYKPSWGATVWIFTSEIWSMNIRGQAVGMCSQVQNVANAIFQQFFPIFLNNCGFYAFYMFAGVNLLLAAFVYLCIPETKQVPLEEIDALFGGANHATRGEEMMLEGKGAQATGVENAQGETAQRVHSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M7B2</accession>
    <name>A0AAJ0M7B2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_80110</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat PROPPIN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727364.1">
        <property type="nucleotide sequence ID" value="XM_062871333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M7B2"/>
    <dbReference type="GeneID" id="87890162"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048720">
        <property type="entry name" value="PROPPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11227">
        <property type="entry name" value="WD-REPEAT PROTEIN INTERACTING WITH PHOSPHOINOSIDES WIPI -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21032">
        <property type="entry name" value="PROPPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="252"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3311584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="398" mass="42868" checksum="748FF50708737B14" modified="2024-07-24" version="1">MNTRTPLETPSSTVVLSVAFNEDCSCFTAGLNTGFCIFNSEPCSLRSTRDFNAGISLAQMMGNANYVGLVGGGKRPKFATNKLVLWDELKSKAILEISALTPVRGVQLSTHLIAIVLQNSVRIYKVTKPPTLSSAYETANNPWGLCCLGQKKIAFPGRTPGHVQLVELATGNVSIIPAHSSPVKALQLSPDGELLSTASETGTLIRVFSTSNCARLIELRRGIDQASIFSLAFSPSGTMLACTSDKSTLHIFDVPHPRRPSPQMLQQQQNGGSSQIFSPQNGSSAADKSDDGKGKWGILSKIPMMPRMFSDVYSFASAPFEVDDEETPAVVTGLPMSESTTLGTSKPPKGVIGWLNESTLIVVGAGTNARWEKFAIHEGSDGRRFCVREGWKRYLPSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GKN5</accession>
    <name>A0AAJ0GKN5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_563143</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717481.1">
        <property type="nucleotide sequence ID" value="XM_062870605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GKN5"/>
    <dbReference type="GeneID" id="87889434"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36847">
        <property type="entry name" value="AMIDOLIGASE ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36847:SF1">
        <property type="entry name" value="AMIDOLIGASE ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3301701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="369" mass="40565" checksum="4A9A1031B6364A76" modified="2024-07-24" version="1">MAPAQMNSFQFGIEIEVLVRSLGKQHGTWATLSKELSRRLKSVGVPNSIQGNDNYREWSIVRELTVQSDNPYDYGVELVSPIYAASSLSALHDDLQKIFTALINPSSSSSNKHKHYYTLLPTPQCSSHVHISSSSCTHHHHHPYHYPSPCFSPTELAGLAKAALYFEHALDQLMPPERRDGEAYWAKSNRSRDNPSLAGLSLAQCLAKIDTAVADPCGDIRPIIEVMNLYSKDTNFARARGRRADFIRGKTYRWNLAGLLAAAGERKAEDMDCGGLGTIEFRQPPGSLTAEDAMSWATLAVAFVAAGVAYGRELGRGEDTVTEVWRGEEGGSLAELWEFLKGGCLALGWDELVPLRVLFARTGLDVDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GKY9</accession>
    <name>A0AAJ0GKY9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein bS6m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_487988</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bS6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717595.1">
        <property type="nucleotide sequence ID" value="XM_062866467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GKY9"/>
    <dbReference type="GeneID" id="87885296"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15465">
        <property type="entry name" value="bS6_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.60:FF:000007">
        <property type="entry name" value="37S ribosomal protein Mrp17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022190">
        <property type="entry name" value="DUF3716"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000529">
        <property type="entry name" value="Ribosomal_bS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035980">
        <property type="entry name" value="Ribosomal_bS6_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribsomal_bS6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00166">
        <property type="entry name" value="S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21011">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21011:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS6M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12511">
        <property type="entry name" value="DUF3716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01250">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54995">
        <property type="entry name" value="Ribosomal protein S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="124"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="567"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="841"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="139"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="204"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="327"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="359"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="570"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="600"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="872"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="895"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="921"/>
            <end position="932"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3301815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1248" mass="139604" checksum="5679F7ACB705F4B7" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GLN3</accession>
    <name>A0AAJ0GLN3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Spliceosomal protein DIB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_297671</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Essential role in pre-mRNA splicing. Also essential for entry into mitosis (G2/M progression) as well as for chromosome segregation during mitosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DIM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718014.1">
        <property type="nucleotide sequence ID" value="XM_062863777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GLN3"/>
    <dbReference type="GeneID" id="87882606"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02954">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000004">
        <property type="entry name" value="Spliceosomal protein DIB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004123">
        <property type="entry name" value="Dim1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052:SF5">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEN 4A, 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02966">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017199">
        <property type="entry name" value="mRNA_splic_U5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01410">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="39"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR017199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR017199-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3302234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="143" mass="16687" checksum="CFDBD6783A7265F9" modified="2024-07-24" version="1">MGSVLLPHLPSGWHVDQAILSEEERVVVIRFGRDHDPDCMRQDEALFKIAERVKNFAVIYLCDIDQVPDFNAMYELYDPCSIMFFFRNKHIMCDFGTGNNNKLNWVLEDKQELIDIIETVYRGAKKGRGLVVSPKDYSTRHKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GLX2</accession>
    <name>A0AAJ0GLX2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_303601</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NOSIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718164.1">
        <property type="nucleotide sequence ID" value="XM_062863844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GLX2"/>
    <dbReference type="GeneID" id="87882673"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016818">
        <property type="entry name" value="NOSIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031790">
        <property type="entry name" value="Znf-NOSIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13063">
        <property type="entry name" value="ENOS INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13063:SF10">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15906">
        <property type="entry name" value="zf-NOSIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF023577">
        <property type="entry name" value="ENOS_interacting"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="264"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="119"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR023577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3302384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="363" mass="39911" checksum="4B6DEDC35E368451" modified="2024-07-24" version="1">MAHSKRNTSRPIFTSHERAMARAAWGSSTARLSRDSFLPFASCWLCLEPAIDPVACMHGDVFCRECALSNILAQKKEIKRAEKAREQEQREAQEEKARRDAEAQERAIREFELTQAGLSIKRGSTSGAGKGETGRPVERESQNEIGKGESYASEKSAVAGVKRKFSLDPDEVGRIAEEERAKARRAIDEEKASKVTLPSFWSPTVTPSSNSNNVLHETTRKAKTQPVCPAAPEDNPHHYSLHTLVTVNFTEEVDSDTKQPRRTCPACNKGLSNSSRATLVKPCGHVLCKNCVDLFMNASSGEPVRCYVCEADITGKTESSSRKEGRTGKEKIRPGLVELRREGTGFSAGGNNQVKKNAVTFTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GM16</accession>
    <name>A0AAJ0GM16_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Eukaryotic translation initiation factor 6</fullName>
            <shortName evidence="6">eIF-6</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TIF6</name>
        <name evidence="7" type="ORF">B0T15DRAFT_487552</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer. Associates with the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
        <text evidence="6">Shuttles between cytoplasm and nucleus/nucleolus.</text>
    </comment>
    <comment type="PTM">
        <text evidence="6">Phosphorylation at Ser-174 and Ser-175 promotes nuclear export.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the eIF-6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GM16"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00527">
        <property type="entry name" value="IF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.75.10.10:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.75.10.10">
        <property type="entry name" value="L-arginine/glycine Amidinotransferase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00032">
        <property type="entry name" value="eIF_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002769">
        <property type="entry name" value="eIF6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00323">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10784">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01912">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006413">
        <property type="entry name" value="IF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00654">
        <property type="entry name" value="eIF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55909">
        <property type="entry name" value="Pentein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="modified residue" description="Phosphoserine; by CK1" evidence="6">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine; by CK1" evidence="6">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3302400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="246" mass="26541" checksum="B8BA6B7E6196E062" modified="2024-07-24" version="1">MAVRAQFENSNEVGVFAKLTNSYALVGIGASENFYSVFEAELQDIIPICRTTIAGMRIIGRLTAGNRKGLLVPTTTTDQELQHLRNSLPDEVKIQRIEERLSALGNVIATNDHTALIHPDLERETEEIIADVLGVEVFRQTVADNVLVGSYMVLSNQGGLVHPKTSIRDQDELSSLLQVPLVAGSVNRGSSVIGGGMVVNDWMAVTGLDTTAPELSVIESVFRLTEGAAPGAVNTSMKDTIVESFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GM57</accession>
    <name>A0AAJ0GM57_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">60S ribosomal protein L2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_514521</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718268.1">
        <property type="nucleotide sequence ID" value="XM_062868128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GM57"/>
    <dbReference type="GeneID" id="87886957"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000020">
        <property type="entry name" value="60S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.950.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000006">
        <property type="entry name" value="60S ribosomal protein L8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="entry name" value="Ribosomal protein L2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_uL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_uL2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_uL2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_uL2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Ribosomal_uL2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="RIBOSOMAL PROTEIN L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL2 RNA-binding" evidence="5">
        <location>
            <begin position="11"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL2 C-terminal" evidence="4">
        <location>
            <begin position="96"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3302488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="254" mass="27423" checksum="674E44A1EEFAB08F" modified="2024-07-24" version="1">MGRVIRNQRKGRGSIFTANTRLRKAPAKFRSLDYAERHGYLRGIVKEIIHDPGRGAPLARVVFNSPYKFKKVTETFIANEGMYTGQFVYAGKNAALTVGNILPLASVPEGTVVSNVEEKPGDRGALGRTSGNYVTVVGHNPDEGKTRIKLPSGAKKVVSSNARGMIGIVAGGGRTDKPLLKASRAKHKFAVKRNRWPKTRGVAMNPVDHPHGGGNHQHIGKASTISRYAAQGQKAGLIAARRTGLLRGTQKTKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GND0</accession>
    <name>A0AAJ0GND0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_495508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3302935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718715.1">
        <property type="nucleotide sequence ID" value="XM_062867103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GND0"/>
    <dbReference type="GeneID" id="87885932"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3302935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="103" mass="11273" checksum="70DDE3DE8B6DD3FB" modified="2024-07-24" version="1">MHLSEVGNFIGSSMGGALKPRHLCRDAYLDQGIRADTLQDPYLTTTPAWNTCMQHMTLSVKARSRFGEEGKAEEKQVGLDPGERAERDGAAGEFRFGRGGNSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GNL0</accession>
    <name>A0AAJ0GNL0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C2H2 type master regulator of conidiophore development brlA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_559694</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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                <person name="Cros-Aarteil S."/>
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                <person name="Pangilinan J."/>
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                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
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                <person name="Chen C."/>
                <person name="Yanf M."/>
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                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
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                <person name="Martin F."/>
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                <person name="Natvig D."/>
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                <person name="Gautier V."/>
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                <person name="Barry K."/>
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                <person name="Grigoriev I.V."/>
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                <person name="Ament-Velasquez S.L."/>
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                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
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    </reference>
    <reference evidence="2" key="2">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Bonometti L."/>
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                <person name="Guillou S."/>
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                <person name="Kuo A."/>
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                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
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                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
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                <person name="Natvig D."/>
                <person name="Lalanne C."/>
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                <person name="Ament-Velasquez S.L."/>
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                <person name="Grigoriev I.V."/>
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                <person name="Gladieux P."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 333.67</strain>
        </source>
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    <comment type="caution">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3303627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="316" mass="34137" checksum="B1DA7748A6A81FF1" modified="2024-07-24" version="1">MPSHLLQRIDPDHTPEKDKSPRGSESPSPAPAPSQVGDSDDTPAGNESESNPAPAASQVDDGDDTPAENESESDLAPVAPAAPVGARKPIYGRRLRKEVDAAKKRAREDELSEALVLAEAEVRRPPTPKKSAPKKSAPKKSTPKKSTPKKSTTEKSTPQKSNPKKSTQKKSAPKENTTGKGTPKKSTPKKSTPKENSKEPAGRYPKRKRKADDEDGDAGDDASDAATQKEEKKGRARKRTKVDHGVDGDDGGDAAPQQKKKPAAKTKKEKHNPKPQEKPAPKSKKDKPASKQETKKGERRSRRLANKRPEVKKGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GPE9</accession>
    <name>A0AAJ0GPE9_9PEZI</name>
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        <submittedName>
            <fullName evidence="3">FAD dependent oxidoreductase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_421163</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719484.1">
        <property type="nucleotide sequence ID" value="XM_062865552.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87884381"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Formyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
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        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="2">
        <location>
            <begin position="145"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="Formyl transferase N-terminal" evidence="1">
        <location>
            <begin position="707"/>
            <end position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3303704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="876" mass="96873" checksum="62D07EFB4D674380" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GPF9</accession>
    <name>A0AAJ0GPF9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_439495</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719499.1">
        <property type="nucleotide sequence ID" value="XM_062865892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GPF9"/>
    <dbReference type="GeneID" id="87884721"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF11">
        <property type="entry name" value="D-ASPARTATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3303719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="242" mass="26656" checksum="C1E87244B79C6D56" modified="2024-07-24" version="1">MQLDALAYLRRLAIEHPAGGVRRVRLIDVSTPKAAAVCCWYAGLLPELEALEVGEGGDGSMVVNPSVFLPWVRKKLEDAGVRFQRISTVESLEELKTFGHGILIDASGLVSRTMLDVRDEELTMDSTYVSVVRSTYGVSVVRSTYGGAFYTFIFGRGDGSAVVSGISHRRGSRRCEEDCPSVSFGEYQILQHLVGIRPLRPVGVRVEKELPNGRKSTIGGYIHSFGLARKVVRLVDEFAFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GPJ7</accession>
    <name>A0AAJ0GPJ7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_504936</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719559.1">
        <property type="nucleotide sequence ID" value="XM_062867515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GPJ7"/>
    <dbReference type="GeneID" id="87886344"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF22">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042459622" description="FAD-binding PCMH-type domain-containing protein" evidence="5">
        <location>
            <begin position="28"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="78"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3303779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="509" mass="53118" checksum="7D37ED985551530F" modified="2024-07-24" version="1">MDGPVFMWRRFPALLALALSSVTSSVASPTPQESATNSSFWPQSCCDALRSSLGAKVSLPSSRAYNSSVSSYWAQQETLIRPDCVVAPTSARDVSTTLKVLVPRRCKFAVRGGGHGAVAGIANIEDGVTIDLRGLNAITVSSDGKTVAVGGGQKWAPVYAKLQPLGLGASGGRNGPVGVGGSTLGGGFGYFAPKVGFACDNVARFEVVLADGDIVTASPSSNPSLWRALRGGGANFGIVTQFTLNTFPLGSIWAGDAYFSAEALQTQTQALYSLTANPNFDVNAGLIVNYAFSPSTGPIITNQYAYAQPTVNPPTFQPFTSSPGQLMNSTSVTTLAAFSAAQEPVSPNGFQQITFSTLFKNDLQMLRDLWNIYTASTGNIAAVSGMQWSLSLIPVPPAIGAQSSARGGNVLGLSIPSEGLIMVLLTATFSSASDYPTVQTAADQLLANIIQAAKSKGLYAPYVDMNHAGKSQDPIATYGAVNQAFLKAVAWQYDPTGVFQTLMPGGFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GPR7</accession>
    <name>A0AAJ0GPR7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_439667</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719596.1">
        <property type="nucleotide sequence ID" value="XM_062865896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GPR7"/>
    <dbReference type="GeneID" id="87884725"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF10">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="424"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="461"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="38"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="517"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="523"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3303816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="541" mass="59587" checksum="FDC7ABDD29227AD0" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GPW5</accession>
    <name>A0AAJ0GPW5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_494392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3303891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719671.1">
        <property type="nucleotide sequence ID" value="XM_062867014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GPW5"/>
    <dbReference type="GeneID" id="87885843"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.20.10">
        <property type="entry name" value="Crystallins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011024">
        <property type="entry name" value="G_crystallin-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49695">
        <property type="entry name" value="gamma-Crystallin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042616097" evidence="1">
        <location>
            <begin position="16"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3303891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="154" mass="16768" checksum="A30FEFCBDAEA4F83" modified="2024-07-24" version="1">MRLLLAAVFTSLVSAIPAKRAQPNIPLDVAIPTSFPPVQDGATPYVTNNADKAKREEAIEGRAAAATLIVDIWEDADRGGRHEGLYTDTQKCYGLFNGWNDRITSLSVPNGYACYFWSDADCQGNRLSVPGGNYIANVGVYGFNDVISSYLCWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GPX2</accession>
    <name>A0AAJ0GPX2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mo25-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_225459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mo25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3303973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719753.1">
        <property type="nucleotide sequence ID" value="XM_062862872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GPX2"/>
    <dbReference type="GeneID" id="87881701"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000257">
        <property type="entry name" value="Conidiophore development protein hymA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013878">
        <property type="entry name" value="Mo25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10182">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10182:SF3">
        <property type="entry name" value="PROTEIN MO25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08569">
        <property type="entry name" value="Mo25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3303973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="370" mass="42533" checksum="7609A71B089C0C05" modified="2024-07-24" version="1">MSFFFGRTRTRTNTVDLAKQARDHVTKLEGPQGAAKAEELAKVLSQMKQVLQGTHEAEPNPEQIAQLVTGMIEEDLLYLLAVHLHRLPFESRKDTQVIFSYVFRFRPPTGPQRPEPLALAYVVERRPQVLVELCRGYDHKESATPAGTVLREVLKSEAAAAIILYDDGDEPGSSSRGVGGINPDRPQSGRGVFWNFFDWIDKSSFEVSADAFTTFRELITKHKELVPRYLAVNFDLFFARYNSVLVQSNSYVTKRQSIKLLGEILLDRANYNIMTAYVDRGEHLKICMNLLRDDRKMVQYEGFHVFKVFVANPHKSLPVQKILIMNRDKLLHFLSHFLEDRTEDEQFIDEREFLIKQIRNMPPAPVPPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQ71</accession>
    <name>A0AAJ0GQ71_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_223661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3303895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719675.1">
        <property type="nucleotide sequence ID" value="XM_062862843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQ71"/>
    <dbReference type="GeneID" id="87881672"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3303895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="198" mass="22551" checksum="05CC3D92423960C8" modified="2024-07-24" version="1">MVRFHPMRRNRRLILGPESPNSQHTRWLLARSQLPRALHGRRILDLTVQLNMIELAQRETSNGFKPRLERFSFASQHLRLISKLSYFPSREIRSPVIMLRRAPFSPTMRLAAAAHPGMHSAVVARSAPKTIVPGLVVVGAVVTGVVALIRAQLRRESEAINRAFSRQNTPEALERRNRSLLVDTEGDPKKTLYNVLNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQD9</accession>
    <name>A0AAJ0GQD9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chitin synthase III catalytic subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_233334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720008.1">
        <property type="nucleotide sequence ID" value="XM_062862977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQD9"/>
    <dbReference type="GeneID" id="87881806"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022057">
        <property type="entry name" value="Chs7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35329">
        <property type="entry name" value="CHITIN SYNTHASE EXPORT CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35329:SF1">
        <property type="entry name" value="CHITIN SYNTHASE EXPORT CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12271">
        <property type="entry name" value="Chs7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3304228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="295" mass="32276" checksum="84E6B27348B3D494" modified="2024-07-24" version="1">MGSTKFGNFDEFCRDTTLPVCNLLSPTDNQAGPWQGCELRGIPLSDNRHLGNLGSILLCGIAIATTVLLLLRSERKRAAVGRREMQAFLLGYLLISICEIFSVGEFPLNSKARLAFSAVHIGAIAATTWMLFLNGIVGYQLMDDGTPLSIGLVLGSALIFLIGVGYIALDTGFSFTGYWNSSYDTPNRNIALYVLYLLLPLLWIVLYFVLETVLVLRVLGEIRPMLFLCSAAVAFAAGQVFDFVVSPYICNGTSGAIDGALFETLFTLVSVVLVWLFWSSITEDDWPMDPGNPYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQM8</accession>
    <name>A0AAJ0GQM8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_398760</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720143.1">
        <property type="nucleotide sequence ID" value="XM_062864967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQM8"/>
    <dbReference type="GeneID" id="87883796"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11380">
        <property type="entry name" value="Ribosomal_S8e_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.168.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.168.20">
        <property type="entry name" value="Ribosomal protein S8e, subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001047">
        <property type="entry name" value="Ribosomal_eS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042563">
        <property type="entry name" value="Ribosomal_protein_eS8_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_Se8/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00307">
        <property type="entry name" value="eS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10394">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3304363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="204" mass="22986" checksum="6057D59FCB4E1D1C" modified="2024-07-24" version="1">MGISRDSRHKRAATGAKRAQLRAGKKRAFELGRQPANTRIGAKRIHVVRTRGGNHKYRALRLDSGNFAWASEGCTRKTRVIVVAYHPSNNELVRTNTLTKSAVVQIDAAPFRQWYEAHYGQPLGRRRQQKQGQVVEETKKSKSVEKKQAARFAASGKVEPALEKQFEAGRLYAVISSRPGQSGRCDGYILEGEELAFYQRKLHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQQ2</accession>
    <name>A0AAJ0GQQ2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_400115</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
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                <person name="Ament-Velasquez S.L."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
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                <person name="Chen C."/>
                <person name="Yanf M."/>
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                <person name="Natvig D."/>
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                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
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                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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</entry>
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    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="LaButti K."/>
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                <person name="Lipzen A."/>
                <person name="Chen C."/>
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                <person name="Daum C."/>
                <person name="Ng V."/>
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                <person name="Natvig D.O."/>
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                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
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                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
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                <person name="Hiltunen Thoren M."/>
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            <dbReference type="PubMed" id="37820761"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
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    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720242.1">
        <property type="nucleotide sequence ID" value="XM_062870464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQU3"/>
    <dbReference type="GeneID" id="87889293"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016929">
        <property type="term" value="F:deSUMOylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016926">
        <property type="term" value="P:protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12606:SF141">
        <property type="entry name" value="GH15225P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12606">
        <property type="entry name" value="SENTRIN/SUMO-SPECIFIC PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="6">
        <location>
            <begin position="972"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="805"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="886"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="825"/>
            <end position="843"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3304462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1183" mass="134480" checksum="B5D90C89C7711C10" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQX0</accession>
    <name>A0AAJ0GQX0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutamyl-tRNA amidotransferase complex subunit Gta3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_494964</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720288.1">
        <property type="nucleotide sequence ID" value="XM_062867067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQX0"/>
    <dbReference type="GeneID" id="87885896"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070681">
        <property type="term" value="P:glutaminyl-tRNAGln biosynthesis via transamidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003837">
        <property type="entry name" value="GatC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049545">
        <property type="entry name" value="Gta3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15004">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT C, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15004:SF0">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT C, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20978">
        <property type="entry name" value="Gta3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl-tRNA amidotransferase complex subunit Gta3" evidence="2">
        <location>
            <begin position="73"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3304508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="216" mass="24157" checksum="A87E7A7D07629E02" modified="2024-07-24" version="1">MTSPRLPLSRLARRRLPLSRPPTRYYSSSTPPPPSPRPQHDPVALLSQPTWSIRTLIPPSSPSNTPLTAPNSTPEEEITPAQLSHLLRLSALPQPSTPQETRRMLATLHAQLHFVRDIQRVNTDGVEPLSSIRDETAEGMRAATITVDTLKSALAEEEVYGRCRRPRRRRRRGDQKKEVVDGAGVEDWDVLGCASEKVGRYFVVRSGSGKKEEEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GR77</accession>
    <name>A0AAJ0GR77_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_512800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720452.1">
        <property type="nucleotide sequence ID" value="XM_062868005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GR77"/>
    <dbReference type="GeneID" id="87886834"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3304672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="171" mass="18429" checksum="3ACCB53A102FE109" modified="2024-07-24" version="1">MAHMANPALTALSASARAWCSRDIDGCDRCNGQMLKCAYPVWYRSESSPARTAALSSFTIHATADPFPVTLPTLLCPCTKDVACKARRFCMSTCRGSSAELYYDVCSHGVLRHSELPLAQPAVAWVARTFQAALDGPALAGSTVLVALWLGVVERPQWWIEASGPGLEGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GRE1</accession>
    <name>A0AAJ0GRE1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hsp70 protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_251649</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720501.1">
        <property type="nucleotide sequence ID" value="XM_062863187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GRE1"/>
    <dbReference type="GeneID" id="87882016"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034663">
        <property type="term" value="C:endoplasmic reticulum chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10230">
        <property type="entry name" value="ASKHA_NBD_HSP70_HYOU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000039">
        <property type="entry name" value="Hsp70 family chaperone Lhs1/Orp150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF3">
        <property type="entry name" value="HYPOXIA UP-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042523512" evidence="6">
        <location>
            <begin position="26"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="600"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="823"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="927"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="600"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="617"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="823"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="941"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="996"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1019"/>
            <end position="1029"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3304721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1029" mass="111535" checksum="7A62A87E63BD6A0A" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GRI2</accession>
    <name>A0AAJ0GRI2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_253466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720594.1">
        <property type="nucleotide sequence ID" value="XM_062863217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GRI2"/>
    <dbReference type="GeneID" id="87882046"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3304814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="178" mass="20566" checksum="D210383D01342118" modified="2024-07-24" version="1">MISDRALPVLSVGGTLHPDAARASRKRAKDDLGDEHEVSRQRSTSRHKEVEEFGDLRSVCLQRKNREVQIREDGKRVQKPIKQRRKMKFCHECKSLWLRTMRFGFPGPSSRQAHASTVIVFGHPCVDGPKMLFLAPSRAILSCLQPFGCFSPLKPTFGFLSRYFEWHCERQTFSLHLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GRL0</accession>
    <name>A0AAJ0GRL0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase family 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_254568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720638.1">
        <property type="nucleotide sequence ID" value="XM_062863227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GRL0"/>
    <dbReference type="GeneID" id="87882056"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21015:SF22">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21015">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--N-ACETYLMURAMYL-(PENTAPEPTIDE) PYROPHOSPHORYL-UNDECAPRENOL N-ACETYLGLUCOSAMINE TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3304858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="456" mass="49860" checksum="FA14C1DD6DC9F80E" modified="2024-07-24" version="1">MDTPKDRPILVAAAFSASGHMTPLLHISEHLVKRGFQVYFITGAEFKASVEKIGATFVENPFQWEQIYFTQAPKVHDETWVMKYIFGDATPHTHRALKETLERVRREHPGCEVVILHESFAGGLGPFVCGAPLPEGYTSLPKAIVFHSSVYASADDQTPPFGPGFRYDPTPENLALWRSTREAMEPGYQGVVAHYNALYQTLGATRPIKDDFLEFVLSLGDATVLATSPSLEYPIRNKPARLRLIGGLPPKPVSPDFAYPVWWPTITSNAALPAGDANKKRVVFVTQGTIHLDYSELLLPTLKALANRADVIVVATLGARGAELEKKPKDDPAWQLPSNALVIDYLPYNALLPYADVFVSNAGYGGFMHGVMNGVPMVLAGALADKGEVCARAEFAGIAINLAAQKPGEDAIGQAVNRVLADEKFKARAMELKKENDEMDALGTFEGIIWEMVGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GRY7</accession>
    <name>A0AAJ0GRY7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_531109</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720804.1">
        <property type="nucleotide sequence ID" value="XM_062869228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GRY7"/>
    <dbReference type="GeneID" id="87888057"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042316724" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="22"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="54"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3305024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="576" mass="63359" checksum="07B59F12E1BF306C" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GS90</accession>
    <name>A0AAJ0GS90_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_502322</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720954.1">
        <property type="nucleotide sequence ID" value="XM_062867429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GS90"/>
    <dbReference type="GeneID" id="87886258"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3305174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="347" mass="38866" checksum="6777CD6113767229" modified="2024-07-24" version="1">MAAGISMSKTAESSRESSADWLGLMNVIPARLRNSLVLGTVAYDFYNEDSYEMTNPGVYAIGIAIKGRKGEFLTVAGIEKVSQCMVDYCQVWKTWEARSGDWSQMTVPERQYMAHAAAVDSVYRGVNKDMTPRFVGGPAIYEKTMMYISWLQKRAERGQAFDETKAVSQRQSPIYVGCTGESIASASAHHDPKGGLCNSSPLLALTLRCIKHEFPNLEPEVIAKCVVPAWRAEHVPLGDHLVTILASSMFYQGRLNIDQPGDGIEAELAKLKEFAERDLYTEYRVAFEKEVEKFQALKKQYDEANEWLYVVRDARRALQAYNAEVAGSRNVEVLRSPDISSFAEEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GSN3</accession>
    <name>A0AAJ0GSN3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_195136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062862502.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="AB_hydrolase_fold"/>
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        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
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        <property type="entry name" value="Abhydrolase_1"/>
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        <property type="entry name" value="alpha/beta-Hydrolases"/>
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    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="81"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3305376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="344" mass="38289" checksum="1999AA87C10A3B5C" modified="2024-07-24" version="1">MRRGLAEAWRSASRPRFVTSTDRVHVRDATLRRSACLRHFGAYAPLCRDIAPTDARIKGLGREIDGEYAVLRDNYETPKHPIVLAHGLLGFAELKLAGSFLPSIHYWRGIREALSANHAEVITASVPPSSSVEKRAAKLAEDIEAQAKGKSVNIIAHSMGGLDARYMISQLHPAGVDVKSLTTVATPHHGSPFADYLINGIGPDYLPRLYDVWQRMTGWEASAFEQLTTRYMAEEFNPKTPDVPAVRYFSYGAMVRHKPPLLSPFRHSHHVIEKREGPNDGLVSVDSSKWGDYKGTLLGVNHLDLINWSNRLRFTVQKLMGHPPSFNAVAFYLDIGDMLAKEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GSV3</accession>
    <name>A0AAJ0GSV3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_398128</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721045.1">
        <property type="nucleotide sequence ID" value="XM_062864939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GSV3"/>
    <dbReference type="GeneID" id="87883768"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37327">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37327:SF1">
        <property type="entry name" value="MICROTUBULE INTERACTING AND TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04212">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="290"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="424"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="572"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="617"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="713"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1004"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="495"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
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            <begin position="265"/>
            <end position="281"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="646"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="819"/>
            <end position="841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3305265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1145" mass="122960" checksum="6CE1EFAEFA36AC9E" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ0GSV5_9PEZI</name>
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        </alternativeName>
    </protein>
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    </gene>
    <organism evidence="15 16">
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Thr) + L-threonine + ATP = L-threonyl-tRNA(Thr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="3"/>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721313.1">
        <property type="nucleotide sequence ID" value="XM_062862569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GSV5"/>
    <dbReference type="GeneID" id="87881398"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01667">
        <property type="entry name" value="TGS_ThrRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00860">
        <property type="entry name" value="ThrRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000003">
        <property type="entry name" value="Threonine--tRNA ligase 2, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000006">
        <property type="entry name" value="Threonine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000005">
        <property type="entry name" value="Threonyl-tRNA synthetase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047246">
        <property type="entry name" value="ThrRS_anticodon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451:SF46">
        <property type="entry name" value="THREONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="THREONINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGS" evidence="14">
        <location>
            <begin position="70"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="339"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="579"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3305533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="774" mass="87813" checksum="41361792614EF01C" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GT63</accession>
    <name>A0AAJ0GT63_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_196794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721210.1">
        <property type="nucleotide sequence ID" value="XM_062862523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GT63"/>
    <dbReference type="GeneID" id="87881352"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3305430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="204" mass="22040" checksum="00E86B5400339DE9" modified="2024-07-24" version="1">MPPMPTMSRGGDTWSEFWVLQGVSARTGFKLATSPLSVDPGDVKNMDILRTGTVNSIGCCRRSFTSNKYSDRSLNKARRSPSLTKNALSPASILSFVSRARPERQAETPCTSAKQQRLARRGPGSSWVTLLTARPHPSCLLLSKTHKICPQSALNKPFRQEGKAQPWACPDTGLLAMGGFHISTSSAQPQPSSPSSPGRRTTGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GTA4</accession>
    <name>A0AAJ0GTA4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Translation machinery-associated protein 16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_207939</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TMA16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721519.1">
        <property type="nucleotide sequence ID" value="XM_062862638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GTA4"/>
    <dbReference type="GeneID" id="87881467"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.170">
        <property type="entry name" value="Translation machinery-associated protein 16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021346">
        <property type="entry name" value="Tma16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038356">
        <property type="entry name" value="Tma16_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13349">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13349:SF2">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11176">
        <property type="entry name" value="Tma16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3305739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="179" mass="20896" checksum="30BC20CF58DA07B0" modified="2024-07-24" version="1">MAKTLEKTRKQIAKKRNGKLEALHEHSRDSKRLHRAQVRDDRLEKIAEARRKRDQPLLARVAFFQDFVREHGNKPLDLEVIQSKINEFVHQHDDEYETAKKARRPGRPPSTREDLLKMKILALDKEYRDGFYMPDLSTETNVQLLSRFEGSWSYLTNLAWVKISASGSIKPSSFPPQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GTW6</accession>
    <name>A0AAJ0GTW6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6594 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_534397</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3306112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721892.1">
        <property type="nucleotide sequence ID" value="XM_062869435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GTW6"/>
    <dbReference type="GeneID" id="87888264"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046529">
        <property type="entry name" value="DUF6594"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502:SF4">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20237">
        <property type="entry name" value="DUF6594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6594" evidence="2">
        <location>
            <begin position="12"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3306112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="287" mass="32202" checksum="D78BA982EDED1BF8" modified="2024-07-24" version="1">MDIENRPEETGFPALARKLAINPDYEGFVFRTFDRLSARNLLHMEAKLACLEWKLDQVDERVAHGDNEGLRSIRAWEAFEESAKHDARPEYLQMKMCEEIKEALKEYQEALLRQHQVASLGEPETRVLKALRNQSHSTQGDPLLAGLAANRLDDSNRWDLVAIRRPVDKDMLFVFLQNHWMFRTTKIPNDTEYYKENHVAWAGAVISTGAAAGLLLGAIVALRVLEDRDVQLGLIGIFMALFAISVAVLTNARRAEVSASTVAYAAFLVVFVSSSPWSSGVGKDCAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GU21</accession>
    <name>A0AAJ0GU21_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">MPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_511935</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M67C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3306087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721867.1">
        <property type="nucleotide sequence ID" value="XM_062867945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GU21"/>
    <dbReference type="GeneID" id="87886774"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061578">
        <property type="term" value="F:K63-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140492">
        <property type="term" value="F:metal-dependent deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070536">
        <property type="term" value="P:protein K63-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08066">
        <property type="entry name" value="MPN_AMSH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000033">
        <property type="entry name" value="AMSH-like protease sst2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044098">
        <property type="entry name" value="STAMBP/STALP-like_MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015063">
        <property type="entry name" value="USP8_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12947">
        <property type="entry name" value="AMSH-LIKE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12947:SF13">
        <property type="entry name" value="FI19924P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08969">
        <property type="entry name" value="USP8_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="10">
        <location>
            <begin position="375"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="260"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3306087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="552" mass="62866" checksum="37EEC3162F43E89D" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GV36</accession>
    <name>A0AAJ0GV36_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ubiquitin-conjugating enzyme/RWD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_552669</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722492.1">
        <property type="nucleotide sequence ID" value="XM_062870301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GV36"/>
    <dbReference type="GeneID" id="87889130"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116">
        <property type="entry name" value="(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116:SF15">
        <property type="entry name" value="(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="4">
        <location>
            <begin position="70"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="215"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3306712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="258" mass="28654" checksum="3E262BDB6B3B4AD8" modified="2024-07-24" version="1">MASRRVQVKNAVNAKTTQAHLTTAPRESAIALRKWHRENCVKELYDRVILEGHAFKDMAVSMTKSTPLVGRMRKLLGQISSLSTDLPKGIYVRHRESRLDVLKVLIIGPADTPYENGLFEFDMFCGLEFPNRPPKMLFRTTGGGQARFNPNLYHDGQISIQAPGSFNLHQNIIEPASSFTVHLEPPPPPATISPQDPLSDIPSFLPPQDPLSDIPSFLAGSANIMPMPPGRARANEAPPAPPKDDDPIWGEIIRRHFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GVC9</accession>
    <name>A0AAJ0GVC9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Exocyst complex component EXO84</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Exocyst complex component exo84</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0T15DRAFT_155894</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Plays a role in both the assembly of the exocyst and the polarization of this complex to specific sites of the plasma membrane for exocytosis. Also involved in assembly of the spliceosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the exocyst complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EXO84 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722646.1">
        <property type="nucleotide sequence ID" value="XM_062862052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GVC9"/>
    <dbReference type="GeneID" id="87880881"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030133">
        <property type="term" value="C:transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000264">
        <property type="entry name" value="Potential exocyst complex component Exo84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1220">
        <property type="entry name" value="Exo84p, C-terminal helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1210">
        <property type="entry name" value="Exo84p, N-terminal helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033961">
        <property type="entry name" value="Exo84"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032403">
        <property type="entry name" value="Exo84_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042561">
        <property type="entry name" value="Exo84_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042560">
        <property type="entry name" value="Exo84_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21426">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21426:SF12">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16528">
        <property type="entry name" value="Exo84_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25345">
        <property type="entry name" value="PH_EXO84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst component Exo84 C-terminal" evidence="14">
        <location>
            <begin position="458"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
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        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
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        <source>
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        </source>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="6">CBS 333.67</strain>
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    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
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                <person name="Steindorff A."/>
                <person name="Ohm R."/>
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                <person name="Natvig D."/>
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                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
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                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
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            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
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                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
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                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
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                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
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                <person name="Brannstrom I.O."/>
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
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                <person name="Powell A.J."/>
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                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GeneID" id="87881031"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
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    </evidence>
    <sequence length="220" mass="24714" checksum="459EF250654C75FB" modified="2024-07-24" version="1">MACCHCHWGERDEAEYNDLQVVLRTALEPHLSICLLTFSAAAPAAQASEVVHEEAEQTRQSTPLGSCRVPWLQKYCSIGSRRTPDYCMQPRHAVSSPSWLAVGREVSHGILCLTGVLEIGETFHVGMSIPENRCAPLAQVVGHGQTYHNFTRSQYLRLAPCLQRSEMTFSEKEKKKRANANRKVQLCLTSASARQRRLSGTCEATTRSRRCETSHWSQNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="15">Non-repetitive/WGA-negative nucleoporin C-terminal-domain-containing protein</fullName>
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    </protein>
    <gene>
        <name evidence="15" type="ORF">B0T15DRAFT_174614</name>
    </gene>
    <organism evidence="15 16">
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Nucleoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the non-repetitive/WGA-negative nucleoporin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723136.1">
        <property type="nucleotide sequence ID" value="XM_062862239.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87881068"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051292">
        <property type="term" value="P:nuclear pore complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036228">
        <property type="term" value="P:protein localization to nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000972">
        <property type="term" value="P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.440:FF:000001">
        <property type="entry name" value="Nuclear pore complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.450:FF:000002">
        <property type="entry name" value="Putative non-repetitive nucleoporin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1880">
        <property type="entry name" value="Nucleoporin, helical C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.440">
        <property type="entry name" value="Nucleoporin, helical domain, central subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.450">
        <property type="entry name" value="Nucleoporin, helical domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007187">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014908">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004870">
        <property type="entry name" value="Nucleoporin_Nup155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042533">
        <property type="entry name" value="Nucleoporin_Nup155_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042537">
        <property type="entry name" value="Nucleoporin_Nup155_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042538">
        <property type="entry name" value="Nucleoporin_Nup155_C_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10350">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10350:SF6">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03177">
        <property type="entry name" value="Nucleoporin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08801">
        <property type="entry name" value="Nucleoporin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like N-terminal" evidence="14">
        <location>
            <begin position="119"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like C-terminal" evidence="13">
        <location>
            <begin position="670"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="441"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3307356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1427" mass="156364" checksum="BE1F5E3DE6990A7F" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GWF8</accession>
    <name>A0AAJ0GWF8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_529220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722890.1">
        <property type="nucleotide sequence ID" value="XM_062869096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GWF8"/>
    <dbReference type="GeneID" id="87887925"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3307110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1009" mass="112099" checksum="51D66CBAF53EC11D" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GWI0</accession>
    <name>A0AAJ0GWI0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Delta-12 acyl-CoA desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_178088</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723211.1">
        <property type="nucleotide sequence ID" value="XM_062862266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GWI0"/>
    <dbReference type="GeneID" id="87881095"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03507">
        <property type="entry name" value="Delta12-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021863">
        <property type="entry name" value="FAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32100">
        <property type="entry name" value="OMEGA-6 FATTY ACID DESATURASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11960">
        <property type="entry name" value="DUF3474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase N-terminal" evidence="9">
        <location>
            <begin position="53"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="8">
        <location>
            <begin position="137"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="27"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3307431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="479" mass="54571" checksum="394845833CEDF7E4" modified="2024-07-24" version="1">MAPAASTSLPAANKPFLRRNITSTTVDSDTSAVVSPIDSPRPSASSTSLSSLASEDAQPQKKYGKLVDTYGNEFEVPNFTIKDIRDAIPKHCYERSAVRSLSYVARDLIYLGTTFYIWNKFVTPEYIPSQALRVVLWGVYTFLQGLFGTGIWVLAHECGHQAFSPSTKLNNFVGWVLHSALLVPYFSWQFSHSKHHKATGNMERDMVFLPRTREQHATRIGRFVHELSELTEETPIFTFLHLLGQQLIGWWNYLLTNVTGHNNHERQREGRGKGKRNGWFGGVNHFDPRSPIFENRDALYILLSDLGLAITITALVYLGKTFGWSNMFVWYFLPYLWVNHWLVAITYLQHTDPSLPHYTEEEWNFVRGAAATIDREFGFIGRHLLHGIIETHVLHHYVSTIPFYNADEATEAIKPIMGRHYRSDTREGPVGFIKAMWKSARWCQWVEPTEGAEGPAKGVLFFRNHNGLGTRPAKMKPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GXK7</accession>
    <name>A0AAJ0GXK7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_93739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723784.1">
        <property type="nucleotide sequence ID" value="XM_062871470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GXK7"/>
    <dbReference type="GeneID" id="87890299"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053203">
        <property type="entry name" value="Cisplatin_resist-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022024">
        <property type="entry name" value="DUF3602"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693:SF2">
        <property type="entry name" value="DUF3602 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693">
        <property type="entry name" value="PROTEIN PAR32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12223">
        <property type="entry name" value="DUF3602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3308004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="162" mass="16814" checksum="BDA3325722D987FA" modified="2024-07-24" version="1">MPSLKSAYTITEPHPTVPQNTYTHSGRGGLGNFFRAPATTPSSGVPTPATSSTTSSNSSSSTRRFYSGRGGAGNAHAAVERPVLSFDEEFQRAEVREKTATISHVGRGGAGNIFSAFSPSSSKGGSGDDGESLARHESGSSDSSTRSVADRLWGRITSVGHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GXM3</accession>
    <name>A0AAJ0GXM3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Aconitate hydratase, mitochondrial</fullName>
            <shortName evidence="9">Aconitase</shortName>
            <ecNumber evidence="9">4.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0T15DRAFT_428579</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3307992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723772.1">
        <property type="nucleotide sequence ID" value="XM_062865690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GXM3"/>
    <dbReference type="GeneID" id="87884519"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000002">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000003">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000004">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1060.10:FF:000001">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1060.10">
        <property type="entry name" value="Aconitase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050926">
        <property type="entry name" value="Aconitase/IPM_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015932">
        <property type="entry name" value="Aconitase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006248">
        <property type="entry name" value="Aconitase_mito-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01340">
        <property type="entry name" value="aconitase_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005558">
        <property type="entry name" value="PRK07229.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160">
        <property type="entry name" value="ACONITATE HYDRATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160:SF2">
        <property type="entry name" value="HOMOCITRATE DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="6 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="10">
        <location>
            <begin position="89"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="11">
        <location>
            <begin position="604"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3307992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="811" mass="87895" checksum="6B625E8436CA8ECD" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GXR5</accession>
    <name>A0AAJ0GXR5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_433406</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723455.1">
        <property type="nucleotide sequence ID" value="XM_062865772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GXR5"/>
    <dbReference type="GeneID" id="87884601"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3307675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="443" mass="50903" checksum="92E83E2A18442166" modified="2024-07-24" version="1">MASLNSASQPCTLASLPLELLAQILSLLPSLVDLKAAVQATSIFHQAYLSDRKRILYVILHATLGNRVFVDAYAVQTTLHFQHLDYLARHDAVEHFVTFIHQRYPVLPTNTILQLPECSVEGLAGISSFFSSTIRPLLQNVFQMFLQKIPLGVEIDPISTLETRQIMRALYRFELWCSLHGAGSGTSPDYPLLLHAGPVNLLMNLFEVYEPWELEEIACIYTLLHKMYKGIFDDVRERFEEEDKALEEANKADAHERYFFPVRRSLHVATHQSTFPEPTYWQTLGIPREDWRNGALSKGLRWHLRVMRASDVFAKLRMILSEVAFLADETSLARALSWEAQTHRRQVQPSSRDGLEPPDLVRISDRLRVTELRQLLLLFGDGAEDKQPLGWVVVFRGKYCNWYGGVLPWELKCWGWVFWDSQRLEKTGMLEKLAGPWTGEPPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GY00</accession>
    <name>A0AAJ0GY00_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_390503</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3307810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723590.1">
        <property type="nucleotide sequence ID" value="XM_062864541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GY00"/>
    <dbReference type="GeneID" id="87883370"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015149">
        <property type="term" value="F:hexose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045263">
        <property type="entry name" value="GLUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503:SF8">
        <property type="entry name" value="FACILITATED GLUCOSE TRANSPORTER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="464"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="581"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="611"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="645"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="671"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="711"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="742"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="299"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3307810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="783" mass="83836" checksum="FE918288BC401BC6" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GYJ6</accession>
    <name>A0AAJ0GYJ6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TBP-associated factor 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Transcription initiation factor TFIID subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_524672</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724322.1">
        <property type="nucleotide sequence ID" value="XM_062868787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GYJ6"/>
    <dbReference type="GeneID" id="87887616"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22931">
        <property type="entry name" value="HFD_TAF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08050">
        <property type="entry name" value="TAF6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000033">
        <property type="entry name" value="Transcription initiation factor TFIID complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.770:FF:000003">
        <property type="entry name" value="Transcription initiation factor TFIID complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.770">
        <property type="entry name" value="TAF6, C-terminal HEAT repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037796">
        <property type="entry name" value="TAF6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011442">
        <property type="entry name" value="TAF6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046344">
        <property type="entry name" value="TAF6_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004823">
        <property type="entry name" value="TAF_TATA-bd_Histone-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02969">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07571">
        <property type="entry name" value="TAF6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00803">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TATA box binding protein associated factor (TAF) histone-like fold" evidence="8">
        <location>
            <begin position="10"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00076308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3308542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="467" mass="50881" checksum="200E3DB14FC280D4" modified="2024-07-24" version="1">MSANDGPKLLWNPDNVRDVADSQGISLSDEPLRVLAQDVEYRIGQVIVEALRFMRAASRTTLTVQDVSQALKVLDVEPLYGYESTRPLRYGEASLGPGQPLFYIDDEEVDFEKVINAPLPKVPRDMSFTAHWLAVEGVQPSIPQNPTTAETASKDLLPKGPGANPALAALAGNDNVSFRPSVKHVISKELILYFDKIQAAILDDDPDEEKKRLREAALESVRSDPGLHQLVPYFVNFITNQVTHHLDDLFVLRQMMELAQALIQNLNLFLDPYASAISAPVLTCLMARKLGGAAPEDGSDTLREQYRLRELAASLLEMIARKYGATNALLRPKLTRTCLKHFLDPVRPPAVLFGAISGVAASGGPEAVRVLVLPNLKSFDAAVLQPLQEKGEAHGLELEMLIGGIMKAIKSIVGGTGIPAANGVNGIDPSREAEQVTEFLGPVIGRRVSRLANHALNRAILDVKHLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GZ89</accession>
    <name>A0AAJ0GZ89_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">LPXTG-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_121747</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724668.1">
        <property type="nucleotide sequence ID" value="XM_062861632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GZ89"/>
    <dbReference type="GeneID" id="87880461"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042600668" description="LPXTG-domain-containing protein" evidence="3">
        <location>
            <begin position="28"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3308888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="522" mass="55793" checksum="C888E8E92BD3057D" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GZC0</accession>
    <name>A0AAJ0GZC0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ZW10 C-terminal helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_525577</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724657.1">
        <property type="nucleotide sequence ID" value="XM_062868854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GZC0"/>
    <dbReference type="GeneID" id="87887683"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990423">
        <property type="term" value="C:RZZ complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046362">
        <property type="entry name" value="Zw10/DSL1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055148">
        <property type="entry name" value="ZW10_C_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12205">
        <property type="entry name" value="CENTROMERE/KINETOCHORE PROTEIN ZW10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12205:SF0">
        <property type="entry name" value="CENTROMERE_KINETOCHORE PROTEIN ZW10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22766">
        <property type="entry name" value="ZW10_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="680"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3308877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="856" mass="94922" checksum="0CDDB4BAC1CA5BD3" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GZF9</accession>
    <name>A0AAJ0GZF9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_391235</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAK3308993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724773.1">
        <property type="nucleotide sequence ID" value="XM_062864577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GZF9"/>
    <dbReference type="GeneID" id="87883406"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13316">
        <property type="entry name" value="PH_Boi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09535">
        <property type="entry name" value="SAM_BOI-like_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000082">
        <property type="entry name" value="Polarized growth protein boi2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037370">
        <property type="entry name" value="Pleckstrin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12092:SF16">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12092">
        <property type="entry name" value="PLECKSTRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
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        <location>
            <begin position="10"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="6">
        <location>
            <begin position="237"/>
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        </location>
    </feature>
    <feature type="domain" description="PH" evidence="5">
        <location>
            <begin position="716"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="92"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="305"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="386"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="487"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="634"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="895"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="939"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="332"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="415"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="493"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="557"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Brannstrom I.O."/>
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
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                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
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                <person name="Ng V."/>
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                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 333.67</strain>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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                <person name="Labutti K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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                <person name="Kuo A."/>
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                <person name="Labutti K."/>
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                <person name="Thoren M.H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
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                <person name="Chen C."/>
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                <person name="Steindorff A."/>
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                <person name="Martin F."/>
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                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
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                <person name="Hutchinson M.I."/>
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                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
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                <person name="Johannesson H."/>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <person name="Bonometti L."/>
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                <person name="Cros-Aarteil S."/>
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                <person name="Kuo A."/>
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                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
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                <person name="Chen C."/>
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                <person name="Ohm R."/>
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                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
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                <person name="Grigoriev I.V."/>
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                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
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        <source>
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        </source>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Kuo A."/>
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                <person name="Ng V."/>
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                <person name="Ament-Velasquez S.L."/>
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                <person name="Powell A.J."/>
                <person name="Barry K."/>
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                <person name="Grigoriev I.V."/>
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                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a central role as a glucosyl donor in cellular metabolic pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>alpha-D-glucose 1-phosphate + UTP + H(+) = UDP-alpha-D-glucose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="3 7"/>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725851.1">
        <property type="nucleotide sequence ID" value="XM_062862927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H1F0"/>
    <dbReference type="GeneID" id="87881756"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-alpha-D-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00897">
        <property type="entry name" value="UGPase_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000001">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000002">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016267">
        <property type="entry name" value="UDPGP_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43511">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000806">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000806-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3310071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="525" mass="58356" checksum="5A6A8E007CC6CC0C" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H1G6</accession>
    <name>A0AAJ0H1G6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_387341</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725881.1">
        <property type="nucleotide sequence ID" value="XM_062864380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H1G6"/>
    <dbReference type="GeneID" id="87883209"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097157">
        <property type="term" value="F:pre-mRNA intronic binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030626">
        <property type="term" value="F:U12 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12246">
        <property type="entry name" value="RRM1_U1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000572">
        <property type="entry name" value="U1 small nuclear ribonucleoprotein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045164">
        <property type="entry name" value="RBM41/RNPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16105">
        <property type="entry name" value="RNA-BINDING REGION-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16105:SF0">
        <property type="entry name" value="RNA-BINDING REGION-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
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        <location>
            <begin position="22"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="141"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="141"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3310101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="197" mass="21073" checksum="1A34AEA3EA76F747" modified="2024-07-24" version="1">MATRSAPPPGLPAKVASVPPNQTLYVTNLPSAKIQKEDLRTALYMLFSTYGAVLDVVALKTMKMRGQAHIVYKDIQTATQAMRSLDGFEFFGRPMKISYAKSKSNIVAKLDGTFKTPAASSAARVEVTDLQQSIFNAPVPGAPSAAAGLPSKPSGADHAMTDAGTPESRGVKRPREEEGPEDESDQDVAMEEESDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H1L3</accession>
    <name>A0AAJ0H1L3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_481617</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725933.1">
        <property type="nucleotide sequence ID" value="XM_062866040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H1L3"/>
    <dbReference type="GeneID" id="87884869"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF5">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="478"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3310153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="544" mass="61517" checksum="71632E313347432B" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H1W9</accession>
    <name>A0AAJ0H1W9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein S9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_570650</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725780.1">
        <property type="nucleotide sequence ID" value="XM_062870843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H1W9"/>
    <dbReference type="GeneID" id="87889672"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000007">
        <property type="entry name" value="40S ribosomal protein S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_uS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_uS9_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569:SF16">
        <property type="entry name" value="RIBOSOMAL PROTEIN S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3310000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="143" mass="15848" checksum="931549291C072404" modified="2024-07-24" version="1">MATTQAVQVFGKKKNATAVARCVQGKGLIKVNGKPLKLFAPEILRAKLYEPVLILGTDKFAEVDIRIRVAGGGHTSQVYAVRQAIAKAIIAYYAKYIDEHSKNLLKTALIQFDRSLLVADPRRCEPKKFGGKGARARFQKSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H1X9</accession>
    <name>A0AAJ0H1X9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_388352</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725795.1">
        <property type="nucleotide sequence ID" value="XM_062864443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H1X9"/>
    <dbReference type="GeneID" id="87883272"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF121">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3310015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="323" mass="34522" checksum="85D17A4CA88B0E6E" modified="2024-07-24" version="1">MLLHRANVPLRLSPLSSPLRLRTNKPSPPSHHVRAITTSPKLQAQTRNRVAIVTGAARGIGRAIALRLAQDGYSVTASDLPALQGQLDSLVSEIQTSAGGDVRAHAHTADVTSPAEVEALVRSSVSELGRLDAMVANAGIAQVKPLLELTPEDVQRMLAVNVAGVHYCFQAAAKQMISQEYGEREGGGEGEGESEVRGKLIAAASIVAFKPFPLMGHYSASKWAVRGLSQVYAMELAKHKITANAYAPGIVDTKMWELIDEGLGRREGKEKGEMIRKYSDDLIALGRTSVPEDVAGLVSFLASKDADYITGQTYVVDGGIIYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H284</accession>
    <name>A0AAJ0H284_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_518664</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726276.1">
        <property type="nucleotide sequence ID" value="XM_062868381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H284"/>
    <dbReference type="GeneID" id="87887210"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020999">
        <property type="entry name" value="Chitin_synth_reg_RCR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12273">
        <property type="entry name" value="RCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3310496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="195" mass="21925" checksum="8CE9D20E62F0F722" modified="2024-07-24" version="1">MAPMAQKLFSRQYDYDGCTLTENGDIDESSCYVPFWNTKTGYIVKWSVFLGIVAIISLYLLLGYMHAQRRIRKGLAPLGYHRFMVSRATLAQVDPRYRYPQPTNVYPYAPEGHYYDMHAMPPPIYDPNAPRPPMYEPPAGSTKFTTAQQQSGPESPQPLEQHVEYTPPAGPPPTSTQLQDIYAPPPGPPPSSTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H2F1</accession>
    <name>A0AAJ0H2F1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Aspartic peptidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_507258</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726381.1">
        <property type="nucleotide sequence ID" value="XM_062867635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H2F1"/>
    <dbReference type="GeneID" id="87886464"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06097">
        <property type="entry name" value="Aspergillopepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000024">
        <property type="entry name" value="Endothiapepsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000026">
        <property type="entry name" value="Endothiapepsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034163">
        <property type="entry name" value="Aspergillopepsin-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF2">
        <property type="entry name" value="ASPERGILLOPEPSIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042544504" evidence="7">
        <location>
            <begin position="21"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="8">
        <location>
            <begin position="132"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3310601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="455" mass="48416" checksum="7AC02E860EF45689" modified="2024-07-24" version="1">MKFTAAAFAASLFAPALVAGAPRVVKVDPSDIKPRNVGGSRIKLPQIYNTHFKQHAKGPRALAKVCRKYNIEMPPELVEVLKGILQDLGIDLPTGKVGGLSASAHNSGKPYTNETDDQGEVSATPQLFDVEYLAPVEIGTPPQTLMLNFDTGSSDLWVFSTETPSRQQNGQTLYRIEDSSTAQKLSNHTWSIQYGDGSRSAGNVYLDTVSVGGVNVFNQAVESATSVSSSFTSDAASSGLLGLAFDSINTVSPTKQKTFISNALESLESPLFTANLKKAEPGNYNFGFIDETEFTGPLSFVDVNSTDGFWQFQASGFSIGSGSNASMLVPVGHSAIADTGTTLLMLPSAIANAYYRRVPQAKSSAQIGGWVFPCNATLPDLTLHIGSYKAVVPGELINFAPADTDSFDTATICYGGIQSMAGLPFAIYGDVFLKAQFTVFDLEGPRLGFAPKPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H2K9</accession>
    <name>A0AAJ0H2K9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nuclear pore complex protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_518257</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
            <location evidence="7">Nuclear pore complex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the nucleoporin Nup84/Nup107 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726130.1">
        <property type="nucleotide sequence ID" value="XM_062868349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H2K9"/>
    <dbReference type="GeneID" id="87887178"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3450.20:FF:000003">
        <property type="entry name" value="Nuclear pore complex protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007252">
        <property type="entry name" value="Nup84/Nup107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003:SF2">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003">
        <property type="entry name" value="NUP107-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04121">
        <property type="entry name" value="Nup84_Nup100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="5 7" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="92"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3310350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="948" mass="107974" checksum="7A718D57AA69899C" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H2M1</accession>
    <name>A0AAJ0H2M1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_36326</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726174.1">
        <property type="nucleotide sequence ID" value="XM_062864159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H2M1"/>
    <dbReference type="GeneID" id="87882988"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000144">
        <property type="entry name" value="ATP-binding cassette sub-family E member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013283">
        <property type="entry name" value="RLI1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009945">
        <property type="entry name" value="PRK13409.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19248">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="144"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3310394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="406" mass="45943" checksum="E0B6CB4D45B4C0E0" modified="2024-07-24" version="1">MRSLTPWLRHILDRDVSHLSGGELQRFAIGTVCVQKADVYMFDEPSSYLDVKQRLSAARIIRSLLRPDDYVIVVEHDLSVLDYLSDYICVLYGQPAVYGVVTLPHSVREGINIFLDGHIPTENLRFRDESLTFRIAEGTEDFVAEKSRAFKYPAMEKTLGNFHLSIEAGSFSDSEIIVMMGENGTGKTTFCRLLAGALKPDGTQKVPEMRISMKPQTITPKFEGTVRQLFFKKIKAAFLSPQFQTDVVKPLKLDDFIDQEVKNLSGGELQRVAIVLALGMPADIYLIDEPSAYLDSEQRIVASRVIKRFIMHAKKTAFIVEHDFIMATYLADRVIVFDGQPGIDAHANKPESLLTGCNTFLKNLDVTFRRDPTNFRPRINKLNSQLDQEQKLSGNYFFLEDVEKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H3P5</accession>
    <name>A0AAJ0H3P5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4187 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_68076</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727037.1">
        <property type="nucleotide sequence ID" value="XM_062871195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H3P5"/>
    <dbReference type="GeneID" id="87890024"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025239">
        <property type="entry name" value="DUF4187"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039249">
        <property type="entry name" value="GPATCH11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21032">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21032:SF0">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13821">
        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01173">
        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4187" evidence="2">
        <location>
            <begin position="303"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3311257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="356" mass="40906" checksum="599A4EC51CFDBB3A" modified="2024-07-24" version="1">MSTLKHNQPPPSKQDEDSEEEDYMSMTFADSSLDPTVNSAQNGETSLQRRLRLKREAEARARPKSKAELAAEEEARREAALSQSLLTSQPKSKGLAMMAKMGFKGGALGKQPQPQQQPPKEHEQQQQQDGDGEEEGGVKEQWPRTEPIRIQIKDGREGIGLESERKRKIREAAEAAGERAKRAKAEEGEYRERMRREREAARLERQVMAGQKVAERIALEKEDEEQGRDTTSSRPLKAVPVVWRGLVRAREEAERDRRMRYDLEQGLSRLPTYEDPEEDEDDRKALGKARTTYVAAEDLDEEDAELDEFNALPPEERLRQVVTYLREGYHYCFWCKFEYPDEKMEGCPGLTEEDHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H3Y8</accession>
    <name>A0AAJ0H3Y8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_520992</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727072.1">
        <property type="nucleotide sequence ID" value="XM_062868538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H3Y8"/>
    <dbReference type="GeneID" id="87887367"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000118">
        <property type="entry name" value="Phosphatase 2C-like domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039123">
        <property type="entry name" value="PPTC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320:SF24">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3311292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="452" mass="49488" checksum="889223C33455CBBB" modified="2024-07-24" version="1">MRRLAARLLTPAAHPRLRETTTVLPSLSNSAFHVTSVTSDLSTPWHPRPRLPPKLLPSQQRQISLTGPLFQDSSTPSNATRSPVTHPPLDEVGRLDSAVFPKLPFRFDTGIALFAKRAPRPFPPPYLSPPSGSFSDPLSTHDRSRDRRRAYVDGQLIQGLTNGDDAVFASEYFIAANDGVGAWSTRPRGHAGLWSRLILHFWATAMFEDAARQGDSYRPDPLAYLQRAYEQTIEATGPPNDWQGTTTAAGAQLHYRHRTSDDNNSSSGGGGSGDDNTVEPLLYVTNLGDSQVMVVRPATREMVYKSTEQWHWFDCPRQLGTNSPDTPANCAVVDEVPIREGDVVLAMSDGVIDNLWGHEIVEKVCESLEAWRAGKIPSRRECLAPDTHSNNRDAGGMQYVADELMEAARAIAVDPFAESPFMEHAIEEGLASAGGKLDDISVVAAICKRNDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H3Y9</accession>
    <name>A0AAJ0H3Y9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA (cytosine-5-)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_409144</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.37" evidence="1"/>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727158.1">
        <property type="nucleotide sequence ID" value="XM_062865347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H3Y9"/>
    <dbReference type="GeneID" id="87884176"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003886">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044027">
        <property type="term" value="P:negative regulation of gene expression via chromosomal CpG island methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.120.10">
        <property type="entry name" value="DNA Methylase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050390">
        <property type="entry name" value="C5-Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031303">
        <property type="entry name" value="C5_meth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10629">
        <property type="entry name" value="CYTOSINE-SPECIFIC METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10629:SF52">
        <property type="entry name" value="DNA (CYTOSINE-5)-METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00105">
        <property type="entry name" value="C5METTRFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00095">
        <property type="entry name" value="C5_MTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="271"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3311378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="758" mass="84856" checksum="544F82588CA3551F" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LXT6</accession>
    <name>A0AAJ0LXT6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_544318</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717446.1">
        <property type="nucleotide sequence ID" value="XM_062870058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LXT6"/>
    <dbReference type="GeneID" id="87888887"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120114">
        <property type="term" value="C:Sm-like protein family complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01730">
        <property type="entry name" value="LSm3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000036">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034105">
        <property type="entry name" value="Lsm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040002">
        <property type="entry name" value="Sm-like_LSM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13110">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="9">
        <location>
            <begin position="60"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3301666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="143" mass="15852" checksum="3B2B59F1AD63EDC6" modified="2024-07-24" version="1">MPLPVHLCAHSAFGLGNLPIIYYESTALHSKARNIPKNGACELKHPTMAEVRNEGSSVAEPLDLVRLLLDEVVCVKLRGDRELKGRLHAYDSHCNLVLGEVEETIYIVDEEDDRDVKTMSKKSEMLFVRGDSVVLIAPHAGSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LXZ9</accession>
    <name>A0AAJ0LXZ9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_506060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717641.1">
        <property type="nucleotide sequence ID" value="XM_062867548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LXZ9"/>
    <dbReference type="GeneID" id="87886377"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3301861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="123" mass="13671" checksum="BEF04ECDA19BC0CE" modified="2024-07-24" version="1">MQKSKTDPKPDAGPASKPTGVAPRKPRPNRPAAAPPLRVEFLWRPAKVDDIEKNTVESAIKKALQTQGHHGHYTADIEVRLVSTIGSGKQANYSVMIKKIQRSQISLTYSLDKHKVQEIECFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LY84</accession>
    <name>A0AAJ0LY84_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_289901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717825.1">
        <property type="nucleotide sequence ID" value="XM_062863695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LY84"/>
    <dbReference type="GeneID" id="87882524"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053203">
        <property type="entry name" value="Cisplatin_resist-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022024">
        <property type="entry name" value="DUF3602"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693">
        <property type="entry name" value="PROTEIN PAR32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693:SF1">
        <property type="entry name" value="PROTEIN PAR32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12223">
        <property type="entry name" value="DUF3602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3302045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="190" mass="19957" checksum="247D31489C18C93D" modified="2024-07-24" version="1">MSDILRRVGRGGAGNFYSKKDVQEAANSTPPDLEAQNNSAEPLANAVTRTQTHSTSSGPSYSRTGRGGAGNFTFRSAGSDTTAPSTDPNSSTAQQEERDLKEQAAVAVAATIAAKPRAGELSGRGGAGNWTGHDGVGAELKEEEERQKKAAELEMQVLRDVEVGLAPPPRAYHHPGRGGRRKGEELTDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LYJ8</accession>
    <name>A0AAJ0LYJ8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_542887</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718199.1">
        <property type="nucleotide sequence ID" value="XM_062869948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LYJ8"/>
    <dbReference type="GeneID" id="87888777"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000173">
        <property type="entry name" value="Mitochondrial 54S ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039927">
        <property type="entry name" value="Ribosomal_mL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21396">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21396:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05047">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="7">
        <location>
            <begin position="32"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3302419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="137" mass="15327" checksum="184A56B4C342D0C7" modified="2024-07-24" version="1">MTVRALQQISTGRNGVGAFILQCKKMNFHYCDWAGSSRGMNGFIKSLLPKFAAAHPQIEFTVSPRPAKHPVIVAQYINGREKAICVRNMEPYEILKKAELLRDASGEKLKRTTKPVTSINESVRGIWSPYHGDGLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LYZ5</accession>
    <name>A0AAJ0LYZ5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bola protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_403914</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the BolA/IbaG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718558.1">
        <property type="nucleotide sequence ID" value="XM_062865232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LYZ5"/>
    <dbReference type="GeneID" id="87884061"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.90">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052275">
        <property type="entry name" value="Mt_Fe-S_assembly_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46188">
        <property type="entry name" value="BOLA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46188:SF1">
        <property type="entry name" value="BOLA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3302778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="173" mass="18856" checksum="7D321764787FB5B9" modified="2024-07-24" version="1">MICRACLRARAALIPTNVRPAEQDLLRAAPRRLLSTVRPCQSQPRVKAVYPSPQLSQCLRQTSSDRLFSTSAASSSASAQPQDAASPSSGALQKPSFLSEGESLVWDRLAAEFEPTQLVVQDISGGCGSMYGIEISSERFRGLTMLRQQRLVNAALGDLMKDWHGVQLKTRVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZ08</accession>
    <name>A0AAJ0LZ08_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_259523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3302941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718721.1">
        <property type="nucleotide sequence ID" value="XM_062863304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZ08"/>
    <dbReference type="GeneID" id="87882133"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3302941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="205" mass="22451" checksum="CABC14684847437E" modified="2024-07-24" version="1">MLPGLWNVDGSQRQYTVKAEAIDRASRHARRFHAEKISVFASNELDDPKQRAEHDQRTDSVQTAAFRGSGSSPSRPWRVSSQDRAPSCHERKAVVAQKRPKTAIWNTGPDDDDALRNLAVLRTRLPLTLSDGVAIVPHTPFGPIRLVVPTSPCARTPTCSGGPRARSGCLAVALNGPDARREIRGPRIPSLLLHLKAEIHREGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZ69</accession>
    <name>A0AAJ0LZ69_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rieske domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_261128</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718783.1">
        <property type="nucleotide sequence ID" value="XM_062863329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZ69"/>
    <dbReference type="GeneID" id="87882158"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21496">
        <property type="entry name" value="FERREDOXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21496:SF0">
        <property type="entry name" value="RIESKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="6">
        <location>
            <begin position="62"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3303003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="178" mass="20032" checksum="52CCB42289F11B23" modified="2024-07-24" version="1">MNLFVNPFRAQTRTGTEWFSVGVASSFPDVSLDAESEPRLCGKRGADTKPGCKIFHVPKTDTSQRTEVDIPPAEETAQDLTDQVLVFQYRSTFHAIDHQCPHSSYPLSQGIPFDIEDFGIVLSAGLTCPKHGWSFDLFSGRSDRGNYKLKIWEVQLRDIDGSETGEKEVWVRRKPRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZC1</accession>
    <name>A0AAJ0LZC1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ketopantoate reductase PanE/ApbA-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_268225</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719024.1">
        <property type="nucleotide sequence ID" value="XM_062863431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZC1"/>
    <dbReference type="GeneID" id="87882260"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000017">
        <property type="entry name" value="2-dehydropantoate 2-reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000609">
        <property type="entry name" value="2-dehydropantoate 2-reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051402">
        <property type="entry name" value="KPR-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708:SF26">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708">
        <property type="entry name" value="PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="5">
        <location>
            <begin position="21"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="6">
        <location>
            <begin position="260"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="178"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3303244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="401" mass="43368" checksum="D5C8427E7DD5A3DC" modified="2024-07-24" version="1">MSEKTREAPKSGASRDRPVHIVFVGAGAVGCFYASRLHHPSHNVHVSLIARSNYKALAEHGVQLQSYSFGNYTFRPHAVFASVAAAASSGPGHWDFIIVTTKALPDRSDDSALIAPLVGPGSCIVLIQNGVGVEEPYRARFPATPIVSAVTVISAEQISPGTVRQNRWTRIHLGPYSNSASFPSSSSSSHNDPCPKGDDTTGALPSPSPSSPSSTGSARDSTDPATLQTAGLERAKQLAEWWTALGGIRDVDVRDEAGLQLIRWHKLCINAAFNPSAVLSGGRGNADMARDPDLRRHLAGVMREIWAAVPQVLDGRRFEDEPDHMASPERILRSSERNEGAKPSMLLDWEAGRPMEVEVILGNPVRIARARGVEMPRLQTVYALVKSMQEVRERRAKAAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M0I6</accession>
    <name>A0AAJ0M0I6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Small subunit of acetolactate synthase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_568324</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetolactate synthase small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720282.1">
        <property type="nucleotide sequence ID" value="XM_062870757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M0I6"/>
    <dbReference type="GeneID" id="87889586"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990610">
        <property type="term" value="F:acetolactate synthase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009082">
        <property type="term" value="P:branched-chain amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04878">
        <property type="entry name" value="ACT_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.260:FF:000001">
        <property type="entry name" value="Acetolactate synthase, small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1150">
        <property type="entry name" value="ACT-like. Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004789">
        <property type="entry name" value="Acetalactate_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027271">
        <property type="entry name" value="Acetolactate_synth/TF_NikR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019455">
        <property type="entry name" value="Acetolactate_synth_ssu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039557">
        <property type="entry name" value="AHAS_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054480">
        <property type="entry name" value="AHAS_small-like_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053050">
        <property type="entry name" value="ALS_regulatory_subunit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00119">
        <property type="entry name" value="acolac_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31242">
        <property type="entry name" value="ACETOLACTATE SYNTHASE SMALL SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31242:SF2">
        <property type="entry name" value="ACETOLACTATE SYNTHASE SMALL SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22629">
        <property type="entry name" value="ACT_AHAS_ss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10369">
        <property type="entry name" value="ALS_ss_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="7">
        <location>
            <begin position="86"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="294"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="192"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3304502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="319" mass="34922" checksum="08BB0F253D68E018" modified="2024-07-24" version="1">MASRSLFASSPAWRRIATQTREAPRLAPSISARYSSSTSAIAYKAIRRRQAPLPVEQPPSWSAQAAVSNILYETPTPSAVPPKRHVLNCLVQNEPGVLSRVSGILAARGFNIDSLVVCSTEVEDLSRMTIVLTGQDGVVEQARRQLEDLVPVWAVLDYTNAPLVQRELLLAKINILGPEYFEELLAHHREMTAEDASAEKVQEPSESSLAETAKDFHPSRLVASEALRHKHEHLKSITYFTHQFGGKVLDISTNSCIVEVSAKPSRIDSFLKLIAPFGILESARTGLMALPRSPLYGPDDDTPVKEADEVVDASQLPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M0K8</accession>
    <name>A0AAJ0M0K8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transmembrane amino acid transporter protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_512711</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720356.1">
        <property type="nucleotide sequence ID" value="XM_062868001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M0K8"/>
    <dbReference type="GeneID" id="87886830"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF458">
        <property type="entry name" value="SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="276"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="320"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="396"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="432"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="475"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="515"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="538"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="570"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="10">
        <location>
            <begin position="201"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="135"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3304576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="605" mass="65264" checksum="4FA368101DE52C94" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M0M7</accession>
    <name>A0AAJ0M0M7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromatin modification-related protein EAF3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Chromatin modification-related protein eaf3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0T15DRAFT_248815</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in deacetylation of histones, chromatin assembly and chromosome segregation. May act as a transcriptional oscillator, directing histone deacetylases to specific chromosomal domains. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MRG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720402.1">
        <property type="nucleotide sequence ID" value="XM_062863143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M0M7"/>
    <dbReference type="GeneID" id="87881972"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18983">
        <property type="entry name" value="CBD_MSL3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.30:FF:000004">
        <property type="entry name" value="Putative Chromatin modification-related protein eaf3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000149">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.30">
        <property type="entry name" value="MRG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008676">
        <property type="entry name" value="MRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038217">
        <property type="entry name" value="MRG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026541">
        <property type="entry name" value="MRG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053820">
        <property type="entry name" value="MSL3_chromo-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880">
        <property type="entry name" value="MORTALITY FACTOR 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880:SF15">
        <property type="entry name" value="MSL COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05712">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22732">
        <property type="entry name" value="MSL3_chromo-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038133">
        <property type="entry name" value="HAT_Nua4_EAF3/MRG15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51640">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MSL3 chromodomain-like" evidence="15">
        <location>
            <begin position="11"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="MRG" evidence="14">
        <location>
            <begin position="127"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="83"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00057322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF05712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF22732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3304622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="319" mass="37142" checksum="9B56C82D0EF1F23C" modified="2024-07-24" version="1">MAPSKQPQPPFQKDERVLCFHMEMLYEAKILDIMSAESGDGWLYKIHYKGWKNTWDDWVPQDRIRKFTDENKELAAQLLAQSKSLQSSKTAKQSAKKGGRASDMSSARGSEERTAGTTTATGRGPRRARDYDLEQKENFYNRPSVKIPVPDHIKSLLVDDWENITKNHQLVPLPHVHPVTEILEDYLAHERPNRQPGSASMDVLEETIVGLRDYFDQALGRLLLYRFERLQYHEMHQLWHSADSNHKSAKDTYGAEHMARLLVTLPELIAQTNMDQQSVNRLREELIKFTNWFSRHVTKYFVPEYENPDQDYLEKVKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M0X1</accession>
    <name>A0AAJ0M0X1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ribonuclease H</fullName>
            <ecNumber evidence="3">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_399603</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase H family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="3"/>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720690.1">
        <property type="nucleotide sequence ID" value="XM_062865019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M0X1"/>
    <dbReference type="GeneID" id="87883848"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13934">
        <property type="entry name" value="RNase_H_Dikarya_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050092">
        <property type="entry name" value="RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642:SF26">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="9">
        <location>
            <begin position="135"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="57"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3304910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="311" mass="33909" checksum="4311C764249450EF" modified="2024-07-24" version="1">MPRGYYLGQGLIPLGYSSSDDDEGPCELPDGRVVCGPHGLVVCGRCCVDYSFMDDVPSNQGNGDDEEEEENDEDRGGNGAEPDFIHDLLGPPLRKGTGRSWPSKFIPSSTTDTPAELFSGRRKHIRVTRYTHRDDASTVLIRTDGACLDNGQANPKAGWAFWHGVSDDGTQLIASARLEAKGPFGAAAAQTSNRAELRAVIAALRFRHWPGEGFGTFVVATDSEYVVEGATKWVKTWMENDWKTSAGADVKNKDLWQALLGEIERVSDDGLAVQFWRIPREWNTAADAAAKSAAAQEAAPSQWMEMIGMNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M112</accession>
    <name>A0AAJ0M112_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Helicase/UvrB N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_187560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720825.1">
        <property type="nucleotide sequence ID" value="XM_062862400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M112"/>
    <dbReference type="GeneID" id="87881229"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase/UvrB N-terminal" evidence="2">
        <location>
            <begin position="49"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3305045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="144" mass="15883" checksum="A8D5F0618ABB30F5" modified="2024-07-24" version="1">MNPLRDLRAVLHIADDSEIWERTCRFFCHDKARTAYDQGVKLLGTTLCLHPHQMEAVYALLQRSFGGHFNGGIVALDTGLGKTIVSLAAVAVIRLVELNHYEVRQEWSTTATDNAGVTMHRRHNPRVSQALIPRATHGASSAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M1T9</accession>
    <name>A0AAJ0M1T9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_213079</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721649.1">
        <property type="nucleotide sequence ID" value="XM_062862695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M1T9"/>
    <dbReference type="GeneID" id="87881524"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3305869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="217" mass="23571" checksum="7945BC4E0C0F61A2" modified="2024-07-24" version="1">MAPTGTLSKHFAANSQTYPALARNISSVVLSNLTVLTLSFFSQGEMNDRMIITDWRGGTEGRQKAHRPTASAGSKESRPATKSPVNVLLRNRTIAFSMCGTHCGRIAPLPPRPLGPNGPATFPSAWGKAVAVWDAEFRYIPPCSLLPLARLENDDPNFMSAIGTLMADVIAAHPTHCAPDRGAWFPDRGEPSTSAACPVRLRDHGFWNVRNVFFLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M2Q8</accession>
    <name>A0AAJ0M2Q8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fungal tRNA ligase phosphodiesterase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_528400</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722622.1">
        <property type="nucleotide sequence ID" value="XM_062869039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M2Q8"/>
    <dbReference type="GeneID" id="87887868"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003972">
        <property type="term" value="F:RNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001690">
        <property type="entry name" value="tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019039">
        <property type="entry name" value="T4-Rnl1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015966">
        <property type="entry name" value="tRNA_lig_kin_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015965">
        <property type="entry name" value="tRNA_lig_PDEase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32004">
        <property type="entry name" value="TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32004:SF1">
        <property type="entry name" value="TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09511">
        <property type="entry name" value="RNA_lig_T4_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08302">
        <property type="entry name" value="tRNA_lig_CPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08303">
        <property type="entry name" value="tRNA_lig_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T4 RNA ligase 1-like N-terminal" evidence="4">
        <location>
            <begin position="198"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA ligase kinase" evidence="3">
        <location>
            <begin position="520"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA ligase phosphodiesterase" evidence="2">
        <location>
            <begin position="678"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="722"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="722"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="738"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3306842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="945" mass="106992" checksum="F09A81091B7E9716" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M2X4</accession>
    <name>A0AAJ0M2X4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="8">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_529150</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7 8">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the peptidase C12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="8"/>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722865.1">
        <property type="nucleotide sequence ID" value="XM_062869087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M2X4"/>
    <dbReference type="GeneID" id="87887916"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09616">
        <property type="entry name" value="Peptidase_C12_UCH_L1_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.532.10:FF:000008">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF17">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="10">
        <location>
            <begin position="34"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="11"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="7">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3307085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="267" mass="28650" checksum="B10D6C99F325B17D" modified="2024-07-24" version="1">MSTSNDPVSLPAATTTTSTSSTSTSADPPSTARAFIPLEANPVLLTDLLHQLGLSPALAMHDVYSLTDPTLLSFIPRPALALLLVFPVSAAYESHRLAEDSLQSEYSGRGDREPVVWYRQTVRNACGMIGLLHAASNGPARDFVQGGSLLERLIRSAEPLAPVARARLIETNEELASAHKSVATQGDTTAPDAQDDVDLHYVCFVKGKDGALWEMDGRRKGPLRRGELEDSEDVLSEKALALGPLKFLEREAADLRFSCVALAGSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M3D4</accession>
    <name>A0AAJ0M3D4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13 14">Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase</fullName>
            <ecNumber evidence="3 14">2.7.4.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B0T15DRAFT_395120</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>1D-myo-inositol hexakisphosphate + ATP = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:37459"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:74946"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:37460"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:10276"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58628"/>
            <dbReference type="ChEBI" id="CHEBI:77983"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:10277"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cytoplasm</location>
            <location evidence="1 14">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the histidine acid phosphatase family. VIP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.24" evidence="3 14"/>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723360.1">
        <property type="nucleotide sequence ID" value="XM_062864765.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87883594"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033857">
        <property type="term" value="F:5-diphosphoinositol pentakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052723">
        <property type="term" value="F:inositol hexakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052843">
        <property type="term" value="F:inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006020">
        <property type="term" value="P:inositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000036">
        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11950:FF:000002">
        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013651">
        <property type="entry name" value="ATP-grasp_RimK-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037446">
        <property type="entry name" value="His_Pase_VIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040557">
        <property type="entry name" value="VIP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750">
        <property type="entry name" value="DIPHOSPHOINOSITOL PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750:SF9">
        <property type="entry name" value="INOSITOL HEXAKISPHOSPHATE AND DIPHOSPHOINOSITOL-PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18086">
        <property type="entry name" value="PPIP5K2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08443">
        <property type="entry name" value="RimK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="VIP1 N-terminal" evidence="18">
        <location>
            <begin position="228"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp fold RimK-type" evidence="17">
        <location>
            <begin position="451"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="98"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="573"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="781"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1116"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1405"/>
            <end position="1465"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="930"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="134"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="148"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="194"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="655"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="788"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="815"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1415"/>
            <end position="1429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1433"/>
            <end position="1451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00071668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU365032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF18086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAK3307580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1465" mass="161549" checksum="609CFDBB9E49F2EC" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M3R0</accession>
    <name>A0AAJ0M3R0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator of RNA polII, SAGA, subunit-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_499835</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3307940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723720.1">
        <property type="nucleotide sequence ID" value="XM_062867353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M3R0"/>
    <dbReference type="GeneID" id="87886182"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024738">
        <property type="entry name" value="Hfi1/Tada1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21277">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21277:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12767">
        <property type="entry name" value="SAGA-Tad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3307940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="458" mass="49853" checksum="807683DF14867B0D" modified="2024-07-24" version="1">MVDINPAALSRPSISLSTPVLAKQSINVSVPSTHKTPKSSQLIPARIDLEPIYTALKASIGAEQWPIYKGTITNFFIGRLNQAELSERIDPLLASPDGSREHLHNQLIAAIIGNVTREMPDQGLAPWVSAHDKPSTTSGNKPVSGDAAERKLKGEVMQLPARDRRRIKDLVHNDSDPYDSLANMFMDHARMRPAKAAEVPASAGGAGLSRMNFDLEIRKRYAQPLAVESGEFPDVSNIEGRMLPFCYEAGLASGHAPDAAQFMSIATETFIKEVLSSIFSRTRSNAPGDSGNAGFGPNNNWIQTHKYRRQLAKEEEAFQRGEVIRDKSGLLPVEAKAASERGPLGMADLRLALEMGDCGLANFPTIVRSVIYSYREGELENWNDYTYVDGRERIADLEGDVEMAEVNGTMAKAEPLTNGISHGGDHMDIDNDLGWWEGAKPADGDFLNGVLDSCLAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M3U2</accession>
    <name>A0AAJ0M3U2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Beta-glucosidase cel3A</fullName>
            <ecNumber evidence="5">3.2.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Beta-D-glucoside glucohydrolase cel3A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Cellobiase cel3A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Gentiobiase cel3A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B0T15DRAFT_390894</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="5"/>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723810.1">
        <property type="nucleotide sequence ID" value="XM_062864560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M3U2"/>
    <dbReference type="GeneID" id="87883389"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000757">
        <property type="entry name" value="Beta-glucosidase G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF5">
        <property type="entry name" value="BETA-GLUCOSIDASE M-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Fibronectin type III-like" evidence="18">
        <location>
            <begin position="612"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00070030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00078013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00083231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00083611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAK3308030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="691" mass="74373" checksum="7CD794B68C69ADEF" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M3V8</accession>
    <name>A0AAJ0M3V8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">TOM7 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_490676</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723851.1">
        <property type="nucleotide sequence ID" value="XM_062866701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M3V8"/>
    <dbReference type="GeneID" id="87885530"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005742">
        <property type="term" value="C:mitochondrial outer membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012621">
        <property type="entry name" value="Tom7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34944">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34944:SF2">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08038">
        <property type="entry name" value="Tom7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3308071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="53" mass="6063" checksum="9C771C56BBE48CBA" modified="2024-07-24" version="1">MFALSEESKERIGKIIEISRVAIHYGYLPLILYLGYTRSDPRPSVIRLLSPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M414</accession>
    <name>A0AAJ0M414_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidase signature domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_523721</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062868713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M414"/>
    <dbReference type="GeneID" id="87887542"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
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        <source>
            <dbReference type="Pfam" id="PF01425"/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
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                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
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        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
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                <person name="Chen C."/>
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                <person name="Natvig D."/>
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                <person name="Ament-Velasquez S.L."/>
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                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062868755.1"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
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            <dbReference type="ARBA" id="ARBA00023239"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3308386.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M494</accession>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
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                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
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                <person name="Ohm R.A."/>
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                <person name="Natvig D.O."/>
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                <person name="Kruys A."/>
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                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="37820761"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
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                <person name="Cros-Aarteil S."/>
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062870253.1"/>
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    <dbReference type="GeneID" id="87889082"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="PANTHER" id="PTHR42264">
        <property type="entry name" value="EPHRIN_REC_LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="164"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
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    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3308491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="297" mass="29825" checksum="45F4F1B98713E245" modified="2024-07-24" version="1">MVPLEEAENLGVANSTPASPPPPAAAASSSGGSPSVTSNTAPPPPTATPAADPAPQTALSPQTTAEVQTSFTTVFIGLSSSTTPTTTTASSSTTSPPTTPHTAAQPSRAFPSDTTGSSGPGTGTGGVLDLAPPDSPSNNNNNNNNNNNNNNNNNNNNNNNENNYLNLVTIGVSSVVGGLVLFLGLFLAARFLYVRRVRARMRRRAAKGKGKMKIKVKGRGTVAITGPVQVPGSGPIMMMQEGKGAEMVPIVMLGGGHRCGGRGGNGNGVGSSSSSRNGEFWGKGGSDGPGGQEGGFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M4V7</accession>
    <name>A0AAJ0M4V7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ER membrane protein complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_509334</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the EMC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724709.1">
        <property type="nucleotide sequence ID" value="XM_062867776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M4V7"/>
    <dbReference type="GeneID" id="87886605"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001208">
        <property type="entry name" value="Tetratricopeptide repeat domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039856">
        <property type="entry name" value="EMC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055217">
        <property type="entry name" value="TPR_EMC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12760">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22890">
        <property type="entry name" value="TPR_EMC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="EMC2 TPR-like" evidence="5">
        <location>
            <begin position="113"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="160"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3308929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="329" mass="36116" checksum="82C6D62E8C31F4F5" modified="2024-07-24" version="1">MAQPVLYPPTQLSPAAALALSQRAPTILRSSPSTVSSSPFSALFAGSEKSELWLQYENLILSCLRTGDENAARQCLQRLVARFGEDNERVQALSGLVKEAEAKSNSALEGILKEYDQILSESDTNIPIVKRRIALLRSMGRVSDATSALVQLLEFSPTDAEAWSELSDIYLSQGLYPQAIYAMEEVLVLAPNAWNIHARLGELQYMAATAPGVAHGSYQKYMAEAIKRFSRSIELCDDYLRGYYGLKLVSKKLLSDGAKATKLPEDGEVSFPDTKTIERLNELATAKLVEIVRHSTAHDRGWRGYSQAEIAAAQELLSEDESAASGIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M5C5</accession>
    <name>A0AAJ0M5C5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="12">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0T15DRAFT_367087</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="12"/>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725486.1">
        <property type="nucleotide sequence ID" value="XM_062864178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M5C5"/>
    <dbReference type="GeneID" id="87883007"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000001">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000227">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024088">
        <property type="entry name" value="Tyr-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032005">
        <property type="entry name" value="TyrRSs_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766:SF0">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766">
        <property type="entry name" value="TYROSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16714">
        <property type="entry name" value="TyrRSs_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tyrosyl-tRNA synthetase C-terminal" evidence="14">
        <location>
            <begin position="440"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="591"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="591"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="613"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3309706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="623" mass="70600" checksum="02D7498131DC7624" modified="2024-07-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M5H7</accession>
    <name>A0AAJ0M5H7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_386897</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725623.1">
        <property type="nucleotide sequence ID" value="XM_062864353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M5H7"/>
    <dbReference type="GeneID" id="87883182"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051430">
        <property type="entry name" value="Fungal_TF_Env_Response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944:SF131">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="27"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="97"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3309843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="769" mass="84327" checksum="5DE457D5C4CFF452" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M648</accession>
    <name>A0AAJ0M648_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF803 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_31844</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726060.1">
        <property type="nucleotide sequence ID" value="XM_062864026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M648"/>
    <dbReference type="GeneID" id="87882855"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3730.20:FF:000012">
        <property type="entry name" value="DUF803 domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF86">
        <property type="entry name" value="ADR321CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="379"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="379"/>
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        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="544"/>
            <end position="556"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3310280.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="577" mass="62906" checksum="7EE129D05E4A103D" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M699</accession>
    <name>A0AAJ0M699_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">B0T15DRAFT_498762</name>
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        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </location>
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        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3310666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M6A0</accession>
    <name>A0AAJ0M6A0_9PEZI</name>
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        <recommendedName>
            <fullName evidence="10">mRNA export factor MEX67</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0T15DRAFT_386339</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium strumarium</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the export of mRNA from the nucleus to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NXF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062864318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M6A0"/>
    <dbReference type="GeneID" id="87883147"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042272">
        <property type="term" value="C:nuclear RNA export factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="UBA_TAP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="mRNA export factor MEX67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000018">
        <property type="entry name" value="Nuclear RNA export factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030217">
        <property type="entry name" value="NXF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005637">
        <property type="entry name" value="TAP_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10662">
        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10662:SF22">
        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22602">
        <property type="entry name" value="NXF_NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03943">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00804">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51281">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NTF2" evidence="12">
        <location>
            <begin position="382"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="TAP-C" evidence="13">
        <location>
            <begin position="586"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3310367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="641" mass="69666" checksum="D3AFC4D4B5379C2A" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M6E3</accession>
    <name>A0AAJ0M6E3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_408057</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726568.1">
        <property type="nucleotide sequence ID" value="XM_062865332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M6E3"/>
    <dbReference type="GeneID" id="87884161"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45782">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45782:SF4">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="4">
        <location>
            <begin position="166"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="371"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3310788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="404" mass="43029" checksum="9625A2F2F90A5551" modified="2024-07-24" version="1">MATTSIAKAAAKSATLLTAGRAAFQARQSYEVSPDIPRSFFLGHHHAGLARMRQMLANVGLIIECRDFRVPITSWNPLLERSLASSSPADGRARIIVYTHRDLGPADQSVSHTAAARLRDFHLAHRHAVEVLFTGQGRSHATAMRDLLAAVKTVARERDALTGLRALVVGMPNAGKSTLLNALRKRGVGAAKVARTGAQPGVTRRLSSPVRIVDAESDGDPSLYGVGEGVFVMDTPGVFVPYVSDPEKMLKLALVGCVKDGIIPKETLADYLLFRLNLAAAAAAAHHPDAGAGFEYVARLNMDAPTNDVSEFLRAVARRVGKLAKGGGVNYEAAAEWAVQEWRSGGLGKLLLDEVTAETLAAAMEAAKDDTLSMNQARKREKEAKKEKNKAKRLGIASGSGGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M6H9</accession>
    <name>A0AAJ0M6H9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Thioredoxin peroxidase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Thioredoxin-dependent peroxiredoxin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_519797</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the peroxiredoxin family. Prx5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726673.1">
        <property type="nucleotide sequence ID" value="XM_062868452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M6H9"/>
    <dbReference type="GeneID" id="87887281"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03013">
        <property type="entry name" value="PRX5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000020">
        <property type="entry name" value="Peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037944">
        <property type="entry name" value="PRX5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430">
        <property type="entry name" value="PEROXIREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430:SF16">
        <property type="entry name" value="PEROXIREDOXIN-5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5 9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="10">
        <location>
            <begin position="4"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="8">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00079296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR637944-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3310893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="166" mass="17619" checksum="D06D93C9FF84D475" modified="2024-07-24" version="1">MATLKPGDAFPSGVAFTYVPPTGTLDLLVCGLPTKYDASKEFQTKKTVLVAVPGAFTPTCQEQHITSYLANLDKLKEKGVDRVIFIASNDAWVMSAWGKANGVKDESILFMSDANADFSRSIGWANGDRTGRYALVIDHGKVVYAGIDTEKGSIANSGAGGVLAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M751</accession>
    <name>A0AAJ0M751_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ERCC4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0T15DRAFT_521181</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727140.1">
        <property type="nucleotide sequence ID" value="XM_062868548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M751"/>
    <dbReference type="GeneID" id="87887377"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000736">
        <property type="term" value="P:double-strand break repair via single-strand annealing, removal of nonhomologous ends"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901255">
        <property type="term" value="P:nucleotide-excision repair involved in interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20078">
        <property type="entry name" value="XPF_nuclease_XPF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10130:FF:000002">
        <property type="entry name" value="DNA repair endonuclease XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006167">
        <property type="entry name" value="XPF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047520">
        <property type="entry name" value="XPF_nuclease"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00596">
        <property type="entry name" value="rad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10150">
        <property type="entry name" value="DNA REPAIR ENDONUCLEASE XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10150:SF0">
        <property type="entry name" value="DNA REPAIR ENDONUCLEASE XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="11">
        <location>
            <begin position="704"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="495"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="497"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3311360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="938" mass="105491" checksum="40F691DCFFBE5D35" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GL62</accession>
    <name>A0AAJ0GL62_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Exportin-T</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Exportin(tRNA)</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA exportin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0T15DRAFT_541471</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
        <text evidence="11">Shuttles between the nucleus and the cytoplasm.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the exportin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3301917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717697.1">
        <property type="nucleotide sequence ID" value="XM_062869860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GL62"/>
    <dbReference type="GeneID" id="87888689"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071528">
        <property type="term" value="P:tRNA re-export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000355">
        <property type="entry name" value="Exportin-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045546">
        <property type="entry name" value="Exportin-T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040017">
        <property type="entry name" value="XPOT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15952:SF11">
        <property type="entry name" value="EXPORTIN-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15952">
        <property type="entry name" value="EXPORTIN-T/LOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19282">
        <property type="entry name" value="Exportin-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="6 11" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Exportin-1/Importin-beta-like" evidence="12">
        <location>
            <begin position="103"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Exportin-T C-terminal" evidence="13">
        <location>
            <begin position="336"/>
            <end position="1005"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF19282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3301917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1019" mass="114246" checksum="0C7BCF78AE04D629" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GLL5</accession>
    <name>A0AAJ0GLL5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7582 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_294680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062863747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GLL5"/>
    <dbReference type="GeneID" id="87882576"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056004">
        <property type="entry name" value="DUF7582"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24483">
        <property type="entry name" value="DUF7582"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7582" evidence="2">
        <location>
            <begin position="205"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="594"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="494"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="609"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3302157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="672" mass="73387" checksum="91C14A9DA1A35BB1" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GLR3</accession>
    <name>A0AAJ0GLR3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosome assembly protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Elongation factor-like 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0T15DRAFT_496756</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718066.1">
        <property type="nucleotide sequence ID" value="XM_062867204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GLR3"/>
    <dbReference type="GeneID" id="87886033"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01681">
        <property type="entry name" value="aeEF2_snRNP_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04096">
        <property type="entry name" value="eEF2_snRNP_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01885">
        <property type="entry name" value="EF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16268">
        <property type="entry name" value="EF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000006">
        <property type="entry name" value="Elongation factor like GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1430.10:FF:000002">
        <property type="entry name" value="Elongation factor like GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000746">
        <property type="entry name" value="Ribosome assembly protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1430.10">
        <property type="entry name" value="Yeast translation eEF2 (G' domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056752">
        <property type="entry name" value="EFL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF3">
        <property type="entry name" value="ELONGATION FACTOR-LIKE GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25118">
        <property type="entry name" value="EFL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="17"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="443"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="753"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="784"/>
            <end position="796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3302286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1089" mass="120066" checksum="40E60675E056A941" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GLR4</accession>
    <name>A0AAJ0GLR4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Small COPII coat GTPase sar1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0T15DRAFT_561962</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the small GTPase superfamily. SAR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718022.1">
        <property type="nucleotide sequence ID" value="XM_062870563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GLR4"/>
    <dbReference type="GeneID" id="87889392"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006687">
        <property type="entry name" value="Small_GTPase_SAR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45684">
        <property type="entry name" value="RE74312P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51422">
        <property type="entry name" value="SAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="28"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="135"/>
            <end position="138"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR606687-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3302242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="187" mass="20601" checksum="1EEA394E588B7B44" modified="2024-07-24" version="1">MAASHMFYYSLSYLGLYRTKPTKLVFVGLNHAGKSSLLQNCADHVPDFAAATSHTSHPGSDSETLIKGNVSFTTLDVGRHHRDRELWIESIRGALGIVFMVDAHDTKRFDEAAAELHALSAAEELEGVPFLVLGNKIDHPDAITTAQVIRDRLRVDEIQNRPIRVFMCSVAARLGYGEGIGWLASKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GM11</accession>
    <name>A0AAJ0GM11_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_496865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062867218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GM11"/>
    <dbReference type="GeneID" id="87886047"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3302397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="237" mass="25748" checksum="55877A9184143EB1" modified="2024-07-24" version="1">MVDGSRKYLDGENVYDATPPSSPRLRRVVPPVSRKQSDNGEVSAPEPPTQASTVQSASPPRAPEVEPLREEESEEVHMDPAANENSALAPKPAAQRTVSPRKLRLRPGRAAPQARATSSLTFSDENESVQKEPAAKEYTAPASDSTTMDNSRPKRAMTRSGRAAPEARTPSTLDEGNENLQSEPAMNHTAAPAPSEPPVQNSTGVERRPSRWSSWRTPLPRDPYPLRSRGKAKNTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GMA4</accession>
    <name>A0AAJ0GMA4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP-dependent RNA helicase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_487650</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062866453.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87885282"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17947">
        <property type="entry name" value="DEADc_DDX27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019236">
        <property type="entry name" value="APP1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052935">
        <property type="entry name" value="Mg2+_PAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208:SF3">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09949">
        <property type="entry name" value="APP1_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="245"/>
            <end position="273"/>
        </location>
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    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="276"/>
            <end position="450"/>
        </location>
    </feature>
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        <location>
            <begin position="411"/>
            <end position="606"/>
        </location>
    </feature>
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            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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            <end position="689"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="729"/>
            <end position="812"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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            <end position="1116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1131"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="573"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="245"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="163"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="206"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="625"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="744"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
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            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1138"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1175"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1203"/>
            <end position="1214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3302574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1333" mass="146548" checksum="9A2FC520A07C8728" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GMF7</accession>
    <name>A0AAJ0GMF7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B0T15DRAFT_543510</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718417.1">
        <property type="nucleotide sequence ID" value="XM_062869995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GMF7"/>
    <dbReference type="GeneID" id="87888824"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF36">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042545969" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="17">
        <location>
            <begin position="28"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="18">
        <location>
            <begin position="35"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAK3302637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="346" mass="36747" checksum="40B07132FE12E4CF" modified="2024-07-24" version="1">MPPPPPSALTLLLLLTTLLTPLLPSLGLLPVASAHSHLAYIIIEGQLYHGFDPRPNQQQQQPAANPPSHVGWSTTAFDDGFVPPANYSTPDIICHVGGTAPPAHAPVRAGDRIHVQWNGWPVGHVGPVLSYLARCESETGCTGLMKGKGKEGLRWTKIDDSRPVMEVSVSGKGDTTDGGEGEGVPGQRWATDVLIASNNSWLVAVPRGLQTGAYVLRHEIIALHFAERENGAQNYPLCMNLFVQGDDEAGGAGFEMDDFDARGFYKADDPGILVNVTAGLQSTYVVPGPTVAVGASPVPYAQQSASVSRGVGTPVVVTRSTETVPFNEVATPTGASRLIRGYDRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GML7</accession>
    <name>A0AAJ0GML7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_577810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718546.1">
        <property type="nucleotide sequence ID" value="XM_062871073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GML7"/>
    <dbReference type="GeneID" id="87889902"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3302766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="207" mass="22102" checksum="D6D0E359C84DA71A" modified="2024-07-24" version="1">MAISSSSHSTVVSPNRSESKGHSTSTRVVSYSGPSKTTCRRRDSISAGGADECRASRAHPTQLVCGDVPGPATGQGREAGRGCAVIMAARKIGRHTSPVEYPDTLRRIPVATRPLREAGSQNLLASATGFERRRMGNCDVAVDEATRPLHTVPFALLRPFVGLPRMVAMAPPGCVLTSESYLSMIDAFLVDCSRALSPQHIKEIGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GMY6</accession>
    <name>A0AAJ0GMY6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aflatoxin regulatory protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_402237</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3302939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718719.1">
        <property type="nucleotide sequence ID" value="XM_062865148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GMY6"/>
    <dbReference type="GeneID" id="87883977"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045122">
        <property type="term" value="P:aflatoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013700">
        <property type="entry name" value="AflR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF31">
        <property type="entry name" value="MONODICTYPHENONE CLUSTER TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08493">
        <property type="entry name" value="AflR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="24"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="63"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="334"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="429"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="334"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="435"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3302939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="493" mass="51578" checksum="B332A0D69F3E4BF9" modified="2024-07-24" version="1">MLDTAVRHSTGHPITQTPRKLRDSCTDCASSKVRCSKEKPTCARCARRGVTCTYMVSRRTGRTSNAAITPASTGSTNAGPTATGTHSTSSRQKEAGKRNGRPSLRVRTPHLSFSSMRGGASAGTGGRNASGQYSPDPISAGPGTLTEADLWSSALTPSALVMDSPRLSPPLTTIGTDIGDFFDMDLHSPMMLDGLEQPSTAETHTDTGTSDLFGDVVSVSDLDGFSSYANGASAFDWAKSHSPPNNCFSVVMDILTRLFPNAPSGCTMPRNRGGTPRVAASGSRTMESVISENKQIIDSLTSLLDCDCTHDEYLISIMAMAALKVMGWYAAAASDDGTPSSPTSSSTSGSASASPATHDQRPPSSSSLGGGRGPLGEQVLRLPTTVGNYCVAGQHQGRMAAQLVLSELHRVQRLVNALSKRLESVRLRTGQAARSGTSSGSSSMGESGDFQGLGLGGGRAPPFSVPTFAQLEGDLRKRLKVLSTEIIDALRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GN06</accession>
    <name>A0AAJ0GN06_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_538674</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3302962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718742.1">
        <property type="nucleotide sequence ID" value="XM_062869698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GN06"/>
    <dbReference type="GeneID" id="87888527"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053187">
        <property type="entry name" value="Notoamide_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="60"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="16"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3302962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="661" mass="74322" checksum="46F5107D748EA5D3" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GN61</accession>
    <name>A0AAJ0GN61_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_538815</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718791.1">
        <property type="nucleotide sequence ID" value="XM_062869702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GN61"/>
    <dbReference type="GeneID" id="87888531"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF5">
        <property type="entry name" value="DUF1996 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042560164" description="DUF1996 domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1996" evidence="2">
        <location>
            <begin position="31"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3303011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="330" mass="35990" checksum="018793F27F3A82F9" modified="2024-07-24" version="1">MKFLSTGLALVGLAEAGLRFPCSTLTFQRLDPVVEPGNNPSAHLHHIVGGNAFNATMTGDVGERATCTTCQMAEDFSNYWTAVLYFKHPNGSYHRVQPAPVQPLLGGSNGAQGGITVYYTQFDLTRDNLKQQPVKSFPPGFRMTVGSPTVTGKPQTGIRYQCLTGQNRGPEMPDFPAKPCSGGIFVTQHFPACWDGKNLDSPDHQSHMYNTIRYDGFMNAGPCPSSHPVRMPQVTYETVWDTTKFNSMWPSGAPNPFVWSFEGTAGGSHADYMFGWKGDALQRAMDKSECFYDGCGSIKKQAMTIANTCTVKDMVGEKTDGWAKALPGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ0GN89_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_262355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718834.1">
        <property type="nucleotide sequence ID" value="XM_062863354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GN89"/>
    <dbReference type="GeneID" id="87882183"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042592276" evidence="1">
        <location>
            <begin position="26"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3303054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="311" mass="34361" checksum="CEDB0408CBAE017B" modified="2024-07-24" version="1">MSRFTLTLLAATWALLLLLIPEAHAWPTPSSSWVPSIKTHRRQQRSCHAERNFRTVSSIYNLTVYPNQLPIFQAGGAGVPKGLFNQNVRGRVDPVGNFTNFEDSIEYFFALSPLPAGNPAKAAITGYQITEFSSQCKEVAASVVYLYCSVWNPGCADHGKPLPPLKQVAFWRFDKKGAVLNYDAWIPNLNSWVAQTTASNATQAEARAGTIYQICAATQMRCTGANAQWSSVEECVTTLSTKPYGNYDEAWGDNIVCRSIHVVLTQVRPDHHCPHVGPTGGGKCVNVPYPENFFSDETLYEQPTGETFMCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GNJ8</accession>
    <name>A0AAJ0GNJ8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_559716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718820.1">
        <property type="nucleotide sequence ID" value="XM_062870515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GNJ8"/>
    <dbReference type="GeneID" id="87889344"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3303040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="460" mass="53056" checksum="205A6FB1F1CBF07D" modified="2024-07-24" version="1">MPMPDYYTHALPDGVNTCVLEDIQLRRKIVSRADNNMMMNPGLTTTTTTTTTTTGKRNTSSSPLLDDDKKELSEALEQEQAALRLALDLSRKQQQQRQEETERRALLEQTRLEAAYRAQQQQHRERSKEAERRGKETGKERRLEEEAIRAAAAAYRVQKRQEEQEKEEEQEERKREHERVVREQLARERELKLQAEMERMRVRAEEKERLLAREEAAAAAAAALKLKVKREHRWQEEMRKEMMAEELKQTQQLLEEAAVARAIEDSIVTETTRKLVDEEGERRRAVEAVKERARREAEARELEERLRKRVGGAATKKGPGGPFGLGFSPLGGARVGEVRAFATHGDGAKPAAYHPTSGPYTGTTYGGDNMGLLNPLREEPTWYDHTPRPAPAPRHDNRLENHFNGFDHWDRELGLGHDGPRVWRKTTTERWETVVEHEGHDRHNGCRRCEEGFKPTRDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GNM7</accession>
    <name>A0AAJ0GNM7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Serine/threonine-protein phosphatase 2A activator</fullName>
            <ecNumber evidence="10">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Phosphotyrosyl phosphatase activator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0T15DRAFT_401225</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the PTPA-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="10"/>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719041.1">
        <property type="nucleotide sequence ID" value="XM_062865096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GNM7"/>
    <dbReference type="GeneID" id="87883925"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008160">
        <property type="term" value="F:protein tyrosine phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04087">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1150:FF:000003">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004327">
        <property type="entry name" value="Phstyr_phstse_ac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043170">
        <property type="entry name" value="PTPA_C_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037218">
        <property type="entry name" value="PTPA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A ACTIVATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03095">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140984">
        <property type="entry name" value="PTPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0697">Rotamase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="343"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3303261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="397" mass="42542" checksum="7F00D703FE9850E5" modified="2024-07-24" version="1">MLGLVEGMIEEAPPEKGPRRFGNVSFRRWYGILGERVDKLLREYLPARMWEEWGQGVKEKEEDLKEEVKAYFMGAFGSAQRLDYGTGHELSFLAFLGCLWKLGAFTPVRGEGGATEGDGDGDGEVERSVVLGVFEPYLKVIRRLILTYNLEPAGSHGVWGLDDHSFLPYIFGSAQLTRPITETEPMPLEGSAPDAPRPSTVVKAASVDLYRESNMYFSAIGFINDVKTGPFWEHSPILFDVSGIKDGWGKINKGMIKMFNAEVLSKFPVVQHFPFGSLFSWDADPEATTPAGSVHLVAHGNSTAASGAPAAGSGPRTGTAAPWAQATQMPGVAAGVPSGPGIPYSRAPWAGTGSSGPTMPRGGVPDTGPAPPTVFPRGKPGTASNQFAVTKAPWAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GNS7</accession>
    <name>A0AAJ0GNS7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Terpene synthase</fullName>
            <ecNumber evidence="4">4.2.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_539985</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the terpene synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.-" evidence="4"/>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719154.1">
        <property type="nucleotide sequence ID" value="XM_062869765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GNS7"/>
    <dbReference type="GeneID" id="87888594"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010333">
        <property type="term" value="F:terpene synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034686">
        <property type="entry name" value="Terpene_cyclase-like_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201:SF4">
        <property type="entry name" value="BETA-PINACENE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201">
        <property type="entry name" value="TERPENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19086">
        <property type="entry name" value="Terpene_syn_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01020">
        <property type="entry name" value="Terpene_Cyclase_Like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3303374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="360" mass="39961" checksum="970B5DC365033C6F" modified="2024-07-24" version="1">MELEGNHPESAVSAHSLCSQQLRIPDLRPAFADWHQGINALYEQAKRAVDARLEGLIANERVLVKVKAADIGLFASGWFPAAPYAVLEAVAFYCVWLFLWDDAIDGASASSDGLAAEEYCRQSVAFVKHHLGLDEPGAVEPKAPTRVCGSFAEVGARICERCGLAQRHELFKHLKEYMEACVTEYRWRLSGKVPTVEQFYSWRLRTSSVDVMLDLSRILNGISLPEDILESAELAAMGLSVNKLLILINELFSLKKELRDGAYGNLIPITMRSSSVDLDAAARSVVQDIYNCIRDFDDNASILRGTVRREHGDKVADHLGTLIRAYQAIATTVLNFSVQSPRYGLLEDRQDDGSFVVTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GPP4</accession>
    <name>A0AAJ0GPP4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_541257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719566.1">
        <property type="nucleotide sequence ID" value="XM_062869844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GPP4"/>
    <dbReference type="GeneID" id="87888673"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042598875" evidence="1">
        <location>
            <begin position="18"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3303786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="178" mass="19113" checksum="61576BEBF6297296" modified="2024-07-24" version="1">MLLLGLIPLLLCLPSLGFGTATTTSSTPIKPWEISHLSTFSPSGRPDSSPWAVVNLTISDPNDTSVSPATCVRQWNFGNETPYDKVIACSEVPGGKWTFVMLEADGADGVTPSPITNFGVRFELEKKKKKKDGGEKWVGDAKFVVGENMSGLCAASGFCSFGLKEELAPFAVRQVQVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GPS0</accession>
    <name>A0AAJ0GPS0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Benzoate 4-monooxygenase cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_557265</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3303879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719659.1">
        <property type="nucleotide sequence ID" value="XM_062870441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GPS0"/>
    <dbReference type="GeneID" id="87889270"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF210">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ASQL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3303879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="501" mass="56510" checksum="6D557C653DBAEC83" modified="2024-07-24" version="1">MTTSTVIIGWGTRLLGTLSSQGTFITLTRVVELCVLAASCYFIRNIYFHPLSQHPGPKAWAASRLPWCLHQYRGNLSQRLHQLHQCYGPVVRVAPDEISYISADAWKTIYGQRSVEMPKDPNFSLLTPSGVQNILTADRETHTRQRRLLSHAFSERALREQEEILQTYCTKLCSQLEERCCSGPVDLFDWYTFATFDLIGDLAFGKSFGCLDSGVSSPFVESIQSGSRELMVNQMLRYYGILFVRPLLPLGGGVTVRARIARGPTADRKDFWHYVLRHMADGEEKSKTTMTEAEMYTNAFSISIAGSEGTATALAGATFLLLRHSEAHREAVREVRGVFTAETDITSANIVGRLPFLEAVLHESMRLYPPVAITLPRRVPEGGETVDGRFVPAGYTVGVNHLACYRSALNFEDPDVFRPERWLDGSGTTTEAFKPFSYGPRACLGKSLAWVELRLILARMLWRFDMQLVETEANLRWLDGQKLWGFWQKPPLLCRLVPVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQ55</accession>
    <name>A0AAJ0GQ55_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_286124</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719635.1">
        <property type="nucleotide sequence ID" value="XM_062863637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQ55"/>
    <dbReference type="GeneID" id="87882466"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046523">
        <property type="term" value="F:S-methyl-5-thioribose-1-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18872">
        <property type="entry name" value="NUDIX_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE"/>
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        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G14290)"/>
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        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="12"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3303855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="542" mass="59248" checksum="68078FFAC7A871DC" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQ87</accession>
    <name>A0AAJ0GQ87_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MINDY deubiquitinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_512332</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719919.1">
        <property type="nucleotide sequence ID" value="XM_062867975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQ87"/>
    <dbReference type="GeneID" id="87886804"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016807">
        <property type="term" value="F:cysteine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990380">
        <property type="term" value="F:K48-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007518">
        <property type="entry name" value="MINDY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033979">
        <property type="entry name" value="MINDY_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18063">
        <property type="entry name" value="NF-E2 INDUCIBLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18063:SF6">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04424">
        <property type="entry name" value="MINDY_DUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MINDY deubiquitinase" evidence="2">
        <location>
            <begin position="379"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="686"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="750"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="775"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="341"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="752"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="806"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="845"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="860"/>
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        </location>
    </feature>
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        <location>
            <begin position="918"/>
            <end position="937"/>
        </location>
    </feature>
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        <location>
            <begin position="943"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="979"/>
            <end position="990"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3304139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="999" mass="106307" checksum="C71D65651C2C4144" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQC9</accession>
    <name>A0AAJ0GQC9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_400210</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720003.1">
        <property type="nucleotide sequence ID" value="XM_062865045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQC9"/>
    <dbReference type="GeneID" id="87883874"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF18">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="12"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3304223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="289" mass="32627" checksum="8C2C43AFB3284E03" modified="2024-07-24" version="1" fragment="single">HSHSPRFTKMRYQLLSELGRGGYGTVYKVLDNYRHQLLAVKIMAQKDESDDTWERRLTSAFKGEAIILPALHHAHIIRCFYSHGWGTPRVEIFMELMEGSLASLMQWPQPPYLESGAVADTVLHQMLQALEHLASLGYVHRDVKPENILYTSSPGLLLGRPAPHPVARSLYHFRLGDFGLCDLAANIDAIRGSELFMAPELLERPRRHMQSHKSDVWALYATVLWTLKADWFRQRGRGKRQTVADFAQAVELDGRITSLSEMAVADPGERATAAEMLKNLYPYMGGCAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQM6</accession>
    <name>A0AAJ0GQM6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein mS23</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">37S ribosomal protein S25, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_383884</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719905.1">
        <property type="nucleotide sequence ID" value="XM_062864266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQM6"/>
    <dbReference type="GeneID" id="87883095"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016939">
        <property type="entry name" value="Ribosomal_mS23_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37799">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37799:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13741">
        <property type="entry name" value="MRP-S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3304125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="136" mass="16514" checksum="3356EE7A2A312C3E" modified="2024-07-24" version="1" fragment="single">RQPRNLFRPTKIVHPEDQLRQEFYRDHPWELARPKLVLELDGQDARYRDWSKGLRQPGMALSGESVVQRQLWLMEARDMPKQQAYDVARKEFYKLRQQEEIERRIAVEEARHYGAYFGKNNLQVGMELEDQVYEHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GRG0</accession>
    <name>A0AAJ0GRG0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Histidine phosphatase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_245686</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720335.1">
        <property type="nucleotide sequence ID" value="XM_062863119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GRG0"/>
    <dbReference type="GeneID" id="87881948"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF32">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000709">
        <property type="entry name" value="6PFK_2-Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="5">
        <location>
            <begin position="133"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="5">
        <location>
            <begin position="237"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="498"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3304555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="659" mass="74038" checksum="302D42303435C20B" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GRY1</accession>
    <name>A0AAJ0GRY1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_531003</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3304977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720757.1">
        <property type="nucleotide sequence ID" value="XM_062869213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GRY1"/>
    <dbReference type="GeneID" id="87888042"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13384">
        <property type="entry name" value="HTH_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3304977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="87" mass="9485" checksum="F7D76C425637525E" modified="2024-07-24" version="1">MVNLAEIGAKLTAGRQPGQELSPTARVAIIGAVAAGASQSAIARAFRIDRTAVYRILQRFESSTTVESKPRTGRLEILICREKRYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GS03</accession>
    <name>A0AAJ0GS03_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_574497</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720826.1">
        <property type="nucleotide sequence ID" value="XM_062870954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GS03"/>
    <dbReference type="GeneID" id="87889783"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3305046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="287" mass="32060" checksum="C1DC7E588D677C47" modified="2024-07-24" version="1">MTLRTTTDLFHSQVLLPLLPLRHERIPCRSARAQQEDFKRKMGLLTTAWSQEARAKFEKQMHVINTAMRDHFFQFACFNQSFIRTLWLGSFPGIVDLPDNLLSDPAAWLNSNTIKGAITTKEGRNNHIVGQYIDVITRGSGKIEQLQRCLDRALHDVDIGDTGIASQAPLKKYACVFASRPGVALIIAAYADKHWASQWEVVLVLSAATADGKKAIECAFRDIPIGCPAKPTLFIATVGTCGTGLDSLKKANHAILFDLPFVESDSKQACGRVWRRGQRFPCYWTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GSC0</accession>
    <name>A0AAJ0GSC0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Beta-xylanase</fullName>
            <ecNumber evidence="10">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0T15DRAFT_531775</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15 16">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="10"/>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721043.1">
        <property type="nucleotide sequence ID" value="XM_062869276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GSC0"/>
    <dbReference type="GeneID" id="87888105"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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            <authorList>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 333.67</strain>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </source>
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        <source>
            <dbReference type="EMBL" id="KAK3305279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ0GSM8_9PEZI</name>
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        </submittedName>
    </protein>
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    </gene>
    <organism evidence="1 2">
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
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                <person name="Ament-Velasquez S.L."/>
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                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
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                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062867905.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87886734"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3305394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ0GT82_9PEZI</name>
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    <gene>
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        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062869349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GT82"/>
    <dbReference type="GeneID" id="87888178"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:fungal-type vacuole"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:xanthine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="NCS2"/>
    </dbReference>
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        <property type="entry name" value="Xan_ur_permease"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00801">
        <property type="entry name" value="ncs2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PURINE PERMEASE C1399.01C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42810:SF2">
        <property type="entry name" value="PURINE PERMEASE C1399.01C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="127"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="186"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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    </feature>
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        <location>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3305709.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="591" mass="62354" checksum="0C5D347D22572138" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GTH7</accession>
    <name>A0AAJ0GTH7_9PEZI</name>
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        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="8" type="ORF">B0T15DRAFT_416826</name>
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    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
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                <person name="Cros-Aarteil S."/>
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
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                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
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                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
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    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_062865478.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF59">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G10370)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="348"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="534"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="579"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="170"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3305878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="622" mass="67679" checksum="FE0A6B3D8B8D229A" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GTK0</accession>
    <name>A0AAJ0GTK0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mitochondrial distribution/morphology family 35/apoptosis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_533480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRIAP1/MDM35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721597.1">
        <property type="nucleotide sequence ID" value="XM_062869367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GTK0"/>
    <dbReference type="GeneID" id="87888196"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990050">
        <property type="term" value="F:phosphatidic acid transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007918">
        <property type="entry name" value="MDM35_apoptosis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46403">
        <property type="entry name" value="TP53-REGULATED INHIBITOR OF APOPTOSIS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46403:SF1">
        <property type="entry name" value="TP53-REGULATED INHIBITOR OF APOPTOSIS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05254">
        <property type="entry name" value="UPF0203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3305817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="85" mass="10059" checksum="60F374EB2EDACD75" modified="2024-07-24" version="1">MSQSLAPECNELKERYDTCFLKWYSEKFLRGVGTKDDNECEALFKDYKTCLRKVLKERGIDKLIEEARDDNRENDATLMGKKRCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GTL7</accession>
    <name>A0AAJ0GTL7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">NFX1-type zinc finger-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0T15DRAFT_435259</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721718.1">
        <property type="nucleotide sequence ID" value="XM_062865812.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87884641"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17936">
        <property type="entry name" value="EEXXEc_NFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06008">
        <property type="entry name" value="NF-X1-zinc-finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001660">
        <property type="entry name" value="NF-X1 finger and helicase protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046439">
        <property type="entry name" value="ZF_RZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041367">
        <property type="entry name" value="Znf-CCCH_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000967">
        <property type="entry name" value="Znf_NFX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF445">
        <property type="entry name" value="NFX1-TYPE ZINC FINGER-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18044">
        <property type="entry name" value="zf-CCCH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20173">
        <property type="entry name" value="ZnF_RZ-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00438">
        <property type="entry name" value="ZnF_NFX"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51981">
        <property type="entry name" value="ZF_RZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0391">Immunity</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="11">
        <location>
            <begin position="34"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="RZ-type" evidence="12">
        <location>
            <begin position="1898"/>
            <end position="1972"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="9">
        <location>
            <begin position="34"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3305938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1974" mass="219157" checksum="9730318FE7FBEB9F" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GTT9</accession>
    <name>A0AAJ0GTT9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_534092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3306021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721801.1">
        <property type="nucleotide sequence ID" value="XM_062869413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GTT9"/>
    <dbReference type="GeneID" id="87888242"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3306021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="309" mass="33672" checksum="6525204C0777B0A6" modified="2024-07-24" version="1">MAQSPLSTPKRKRSEMLIDGIPTLDTTTQFTFDLSSSQEDGSASPRTRVAHRFRGLALGGESGANGPPAAVKTVDDDVAAGSRKRIRLPEVEMQDPDPPPPTSIPESQPSDLPVDQSSPGRRGRSPNSVRIAIDDAVVEQSETVANTGMDADARPPPQPRSQTRPRASRRAGTPPLSTTTKPKSKSKSTSPSRPAITDPLRASLTWHDDEITIYDPDDSDDDGAGINGIGFKPTPAIAYARTVRRRQQLAEYRKREEREARAKRSLNRRRGRGESPVPSALAMETAAGRKEGKAERRRVRFLESQVGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GTX6</accession>
    <name>A0AAJ0GTX6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_511973</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3306127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721907.1">
        <property type="nucleotide sequence ID" value="XM_062867951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GTX6"/>
    <dbReference type="GeneID" id="87886780"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF3">
        <property type="entry name" value="OXIDOREDUCTASE AN1597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3306127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="308" mass="35264" checksum="0F781B830BAA1356" modified="2024-07-24" version="1">MATTVLTETQGINGSVTEKDPRMTDEFQTYRVGSGPQQDVSAYIFYSKVSADGTKPTERDLPFLKGEFTDARRVVIHDARGQGKNLDENGFEYITHPKPEADYSDPNSVRQVYYPAMMMQLIKQKLGASEVLIFDHRVRQSSFSTKYGTEYQSYTGPVIRPHVDFAPVHAPAFLQRIRPTNHAQYAGRRWQVINFWRPLRRIERDPLAVADAPTVPEATDELVHLAYAGTPRQTETFLTLAGGSEGAHQWYYYPHQEPDEVLAFKIYDSHPPRENARCVPHTSFRWLDVPEDTPPRHSIEIRCFIAYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GUC6</accession>
    <name>A0AAJ0GUC6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_491903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722132.1">
        <property type="nucleotide sequence ID" value="XM_062866815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GUC6"/>
    <dbReference type="GeneID" id="87885644"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3306352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="223" mass="24168" checksum="3A49892A1C7E407B" modified="2024-07-24" version="1">MPRKWDINGDEERLPEGVRRTGYDADTQTYTYEADDGSVYDGAPGQLYGRLTKTAESVRSRRTTTTTTSSSSSPSQCTTSTSPERGTPPSSPPRSRSGSPQTFSTILNNNKNNTPSSHPRRAASSSSSAAAARPYTPKSIPYHTTTAAASPTTTMGSSSSLRTHPTAKGAAKVLASDLKEYTREAAISVMLRMSKSIRKRTRAKRAANERGWVVEEKEGEEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GUE1</accession>
    <name>A0AAJ0GUE1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_395083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722147.1">
        <property type="nucleotide sequence ID" value="XM_062864764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GUE1"/>
    <dbReference type="GeneID" id="87883593"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056021">
        <property type="entry name" value="DUF7600"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24539">
        <property type="entry name" value="DUF7600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="209"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3306367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="706" mass="79203" checksum="DB04A684144A7E7C" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GV24</accession>
    <name>A0AAJ0GV24_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_372950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722446.1">
        <property type="nucleotide sequence ID" value="XM_062864214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GV24"/>
    <dbReference type="GeneID" id="87883043"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3306666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="625" mass="70769" checksum="85B55A34DAFC78BD" modified="2024-07-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GV26</accession>
    <name>A0AAJ0GV26_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_483979</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722477.1">
        <property type="nucleotide sequence ID" value="XM_062866198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GV26"/>
    <dbReference type="GeneID" id="87885027"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF2">
        <property type="entry name" value="SRPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="74"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="457"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="457"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3306697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="484" mass="53371" checksum="E25F1124FE7CB254" modified="2024-07-24" version="1">MPNEPCASSLPVNRIVQRHSAGLGYYLTLSSGPAQFSIRAPYETLSHDPYPTMSDSFVTEAFTLLGVGLSIIGLRLYVRISQAGLKRLHADDYLMVVAAVTYSIETYLAYSVGTFWKGLANNGMTDEQRRLLDPHSEEYRLRVNGSKTQVAGWSTYTFLLWTLKAAMCTLYLRLTDGLNYEKRIYAGFVIIVVTWISVLLSILLGCRPLEKNWQIHPDPGNFCQPAISKIDIFVTVVLNVVTDLYLMSIPIPMLWNSSLKPLKKAGLILLFSGGIFVTVAAILRCILIITDPVNGAQQAGSWAVRETFVAVITSNLPMITPLIAHWARPIIGTLRSLTSSNKLSGLSRSSRSGNKRGAFVLEDKNPRRGMGPRSVNPIPVTTINGSDEHINPPQADDGRVTSYETDIELGRVASQSKHGAIIKKTSVEVTESRVGEPEEAGTGQDIGDYYLVRQSKQDAERLAEREAAGDGRTSSMQRPFDVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GVP7</accession>
    <name>A0AAJ0GVP7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein HGH1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_395987</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HGH1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722811.1">
        <property type="nucleotide sequence ID" value="XM_062864807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GVP7"/>
    <dbReference type="GeneID" id="87883636"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039717">
        <property type="entry name" value="Hgh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007206">
        <property type="entry name" value="Protein_HGH1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007205">
        <property type="entry name" value="Protein_HGH1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13387">
        <property type="entry name" value="PROTEIN HGH1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13387:SF9">
        <property type="entry name" value="PROTEIN HGH1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04063">
        <property type="entry name" value="DUF383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04064">
        <property type="entry name" value="DUF384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein HGH1 N-terminal" evidence="4">
        <location>
            <begin position="94"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Protein HGH1 C-terminal" evidence="5">
        <location>
            <begin position="283"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3307031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="353" mass="39926" checksum="ECCCD4A5E044DC66" modified="2024-07-24" version="1">MPTELEELVGFIGHPNPQIRKLATENLVPYSTSQPSIFKSEELLPVKHLKFLINDHPTIAEHALTILVNLTADSKILEYVATDDRFLGTLLSYLVVPAEPNANVLAMLLANMAKWDGLKSIAARKQDPPKELQSNELVLNQLLDLFVKGADGTYNEHANFDYLAYVFADLSKHAEIRQFFLTKQDYDGDVPLNKLRVFTEHKSDIRRKGVASTIKNVAFDVPAHPAFLDEGQVNILPYILLPITGNEEYDVEETMEMLPELQLLPPDKQRDPDPSIVQTHVETLTLLTTTRVGRDLMRRVNVYPIIRETHLRVDDEGVREACERLVQVLMRDEAEPEAEAAAESDEDDRIVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GW77</accession>
    <name>A0AAJ0GW77_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_529745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723033.1">
        <property type="nucleotide sequence ID" value="XM_062869125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GW77"/>
    <dbReference type="GeneID" id="87887954"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3307253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="72" mass="7760" checksum="51CD87BB4906D70E" modified="2024-07-24" version="1">MVLLFHLVLLSSSLTITLYTIYCSLSLSFNISYSEMDLLGIPIHLSPCLHGSLTVTSNNLSRNLDCPSAAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GWN7</accession>
    <name>A0AAJ0GWN7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fatty acid synthase subunit alpha</fullName>
            <ecNumber evidence="3">1.1.1.100</ecNumber>
            <ecNumber evidence="4">2.3.1.41</ecNumber>
            <ecNumber evidence="2">2.3.1.86</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="29" type="ORF">B0T15DRAFT_414631</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="29">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="29" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="29">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>a fatty acyl-[ACP] + malonyl-[ACP] + H(+) = a 3-oxoacyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:22836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
            <dbReference type="EC" id="2.3.1.41"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>acetyl-CoA + n malonyl-CoA + 2n NADPH + 4n H(+) = a long-chain-acyl-CoA + n CoA + n CO2 + 2n NADP(+).</text>
            <dbReference type="EC" id="2.3.1.86"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 22">Belongs to the thiolase-like superfamily. Fungal fatty acid synthetase subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="29">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="3"/>
    <dbReference type="EC" id="2.3.1.41" evidence="4"/>
    <dbReference type="EC" id="2.3.1.86" evidence="2"/>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723234.1">
        <property type="nucleotide sequence ID" value="XM_062865447.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87884276"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005835">
        <property type="term" value="C:fatty acid synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004321">
        <property type="term" value="F:fatty-acyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042759">
        <property type="term" value="P:long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00828">
        <property type="entry name" value="elong_cond_enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08950">
        <property type="entry name" value="KR_fFAS_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.470.20:FF:000005">
        <property type="entry name" value="Fatty acid synthase alpha subunit FasA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2490:FF:000001">
        <property type="entry name" value="Fatty acid synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.25.70:FF:000001">
        <property type="entry name" value="Fatty acid synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="entry name" value="4'-phosphopantetheinyl transferase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00101">
        <property type="entry name" value="AcpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002582">
        <property type="entry name" value="ACPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040899">
        <property type="entry name" value="Fas_alpha_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047224">
        <property type="entry name" value="FAS_alpha_su_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026025">
        <property type="entry name" value="FAS_alpha_yeast"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041550">
        <property type="entry name" value="FASI_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050830">
        <property type="entry name" value="Fungal_FAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004568">
        <property type="entry name" value="Ppantetheine-prot_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00556">
        <property type="entry name" value="pantethn_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982:SF21">
        <property type="entry name" value="FATTY ACID SYNTHASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982">
        <property type="entry name" value="MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18325">
        <property type="entry name" value="Fas_alpha_ACP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18314">
        <property type="entry name" value="FAS_I_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000454">
        <property type="entry name" value="FAS_yeast_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="4'-phosphopantetheinyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 24" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 24" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="15" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-0521">NADP</keyword>
    <keyword evidence="14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 22 25" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 22" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="27">
        <location>
            <begin position="140"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="28">
        <location>
            <begin position="1087"/>
            <end position="1628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="96"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="26">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="active site" description="For beta-ketoacyl synthase activity" evidence="23">
        <location>
            <position position="1273"/>
        </location>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1748"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1749"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1750"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1851"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="25">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRNR" id="PIRNR000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR000454-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR000454-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PIRSR" id="PIRSR000454-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="KAK3307454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1865" mass="205238" checksum="7775F339841F7D66" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GWS4</accession>
    <name>A0AAJ0GWS4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-nitropropane dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_180862</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723292.1">
        <property type="nucleotide sequence ID" value="XM_062862307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GWS4"/>
    <dbReference type="GeneID" id="87881136"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF31">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G09850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3307512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="377" mass="40608" checksum="71196B3D41674CDC" modified="2024-07-24" version="1">MASPQKIRTEITDLFKINHPILLAGMNVAAGPKLAAAVTNAGGLGVLGGINYTPEMLKDQIDELKSHLHDKKAPFGVDLLLPQVGGNARKTNYDYTKGKLDQLIDIIIESGAKLFVSAVGVPPRHVVEKLHKNGIIYMNMIGHPKHVKKCLDLGVDIICAQGGEGGGHTGDIATTVLIPAVVQAVKGHKSPLTGRPVQVIAAGGIHNGQLLAAALMMGASAVWVGTRFVLSEEAGAPESHKEAVRTASFDDTVRTLIFTGRPLRVRKNPYIMNWEEERQQEIKELTSQGKLPYEADLDKVMSGEAEQTPALKGLKESAGDDVDVEDLLDQFRPFLMGQCAAVCNDKKPAKQIVDEFIDDATACLKQGNSYLARESKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GXF8</accession>
    <name>A0AAJ0GXF8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_508481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3307961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723741.1">
        <property type="nucleotide sequence ID" value="XM_062867724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GXF8"/>
    <dbReference type="GeneID" id="87886553"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="195"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3307961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="381" mass="39984" checksum="3F6EBC968F5DA474" modified="2024-07-24" version="1">MFYATPRFAASTPRPSSTQARAGFTTPALAIKPRAPRTRSTQDIIDDSSPISPNGGSPSASPNTRTTVPEPIEPDSSLVPQSSHPEPLERGRSPKRRRISIASSDSETGSAPSSQGSERTDVEFLPDAPNQHILSNSSDTDDDEVNQRGREASILPSQSAAFSPRCPQSPDIKSEGEFGSVDSDSEKADSENNQATPRPTRAKPAFRAAPRFKVTEPSDQLYSQPDIYLTDPFSPQRRGARYLPGGLAAELRDWLVDVKGGVDGAGEVKTSSAALSFSSATTTASVVVDEASLSGPGITLISGRLVDAPAGGRQDAEVRLILAGEGNIEGLGGGRGGGNRGSVAPGAVISIAPPAWDVELDSRWAVAYRWEAVKRPGGDVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GXI3</accession>
    <name>A0AAJ0GXI3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_499829</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3307932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723712.1">
        <property type="nucleotide sequence ID" value="XM_062867352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GXI3"/>
    <dbReference type="GeneID" id="87886181"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39472">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39472:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="259"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="304"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3307932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="315" mass="34411" checksum="93CBCD188DDE8729" modified="2024-07-24" version="1">MNGMNGGNMPGAMVGFPTPAGHQAELNYIYGMVEELSRQLAENQRTLEEVVAGVGRVRSHAKAQQLGNEELISGAADEVKAQEPNLDTLISILSEALEKAKFSRDANAALLSQYASALAGMLKQFHDYKAKHVADVAAWHRSYRAQLAEARAENSRLREQIWEMQARAGAANEMLRRFRTRYDADEARWERRVEAKAVRQELRFWKRMAMPHLEDDDSCWSDDDDLIDVAEKKRLEEMQKLAAEQQLAAAAAELGDIVGGGGDDGGVPPEVPSAPVPQSMIGGVPMQRDDGGSMMLPIPPPRPSSVASSTGSSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GXL6</accession>
    <name>A0AAJ0GXL6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_572053</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3307740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723520.1">
        <property type="nucleotide sequence ID" value="XM_062870880.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87889709"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF1">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="1109"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="2174"/>
            <end position="2250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="78"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3307740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="2706" mass="295633" checksum="DFC957A725CEF21B" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GXU7</accession>
    <name>A0AAJ0GXU7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Emp24/gp25L/p24 family/GOLD-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0T15DRAFT_523693</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723946.1">
        <property type="nucleotide sequence ID" value="XM_062868712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GXU7"/>
    <dbReference type="GeneID" id="87887541"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042487967" evidence="10">
        <location>
            <begin position="23"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="11">
        <location>
            <begin position="32"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3308166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="210" mass="23730" checksum="17B416D9A474045C" modified="2024-07-24" version="1">MQFPLLSCGLWALLAVQATATALTYKLGANEEACFYTASKTKDEKIAFYFAVQSGGSFDVDYKVTGPNGKYIMSGEKERQGDFVFTAREVGEYKFCFNNEMSAYTEKFVDFEIAVENEARVTLPAKQGASPEHTESLEESLFKISGQLSTITRNQKYFRTRENRNFSTVRSTEKRIINFSLIQMALVVCMGALQVFIVKFFFQGARKGYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GY94</accession>
    <name>A0AAJ0GY94_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Prokaryotic-type class I peptide chain release factors domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_97612</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723880.1">
        <property type="nucleotide sequence ID" value="XM_062871507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GY94"/>
    <dbReference type="GeneID" id="87890336"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:mitochondrial translation"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="Related to MRF1-peptide chain release factor, mitochondrial"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PCRF"/>
    </dbReference>
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        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
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        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050057">
        <property type="entry name" value="Prokaryotic/Mito_RF"/>
    </dbReference>
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        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="5">
        <location>
            <begin position="279"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="72"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3308100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="428" mass="47430" checksum="E283F6D80FBD9E93" modified="2024-07-24" version="1">MLTAPWVCWNCARSLARTGICHFIRRSSTESSIKLPPALLERARRLAAEHDQLSAALAKDFDPKKAKRAGEISRIASALQQFEKAKEALRELQGLLDSNDAELRELAKDDLEATHAQLADSSRNLSVALTPKHPFADMPCLLEIRPGPGGTEGRFFADSLFHMYKAYCSNKGYRTRTVKYEASDSDGQTGSEGEIALQEAVLEIQEPGAYGTFRGEAGMHRVQRVPATEKSGRTHTSAVAVWVLPSFPENGTSESEADWDNPESDFYIDPTEVRSETMRARGAGGQHVNKTESAIRLTHIPTGTTVSMQDSRSQQQNRASAWRLLRSRIAQQRREAREEMARQLRSSVLANNQITRGDKIRTYQYQQDRCTDHRSGLDAHNLPDVLRGGETLGKVMESVQTWLINKDIQALIADEEAAAAVAAGKEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GYC2</accession>
    <name>A0AAJ0GYC2_9PEZI</name>
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        <recommendedName>
            <fullName evidence="3">dolichol kinase</fullName>
            <ecNumber evidence="3">2.7.1.108</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0T15DRAFT_410422</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the polyprenol kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.108" evidence="3"/>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723925.1">
        <property type="nucleotide sequence ID" value="XM_062865376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GYC2"/>
    <dbReference type="GeneID" id="87884205"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004168">
        <property type="term" value="F:dolichol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043048">
        <property type="term" value="P:dolichyl monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032974">
        <property type="entry name" value="Polypren_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13205:SF15">
        <property type="entry name" value="DOLICHOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13205">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="543"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="641"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="694"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="739"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="779"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="819"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="482"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="482"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3308145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="921" mass="100245" checksum="BAD4CF9E00F88D54" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GYZ4</accession>
    <name>A0AAJ0GYZ4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_565815</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724509.1">
        <property type="nucleotide sequence ID" value="XM_062870676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GYZ4"/>
    <dbReference type="GeneID" id="87889505"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182:SF2">
        <property type="entry name" value="LYTIC POLYSACCHARIDE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042525689" evidence="2">
        <location>
            <begin position="20"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="245"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3308729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="270" mass="26992" checksum="35FF5646F1C8C428" modified="2024-07-24" version="1">MFFAKSFIAAGGLAAVAHGHMLLRVPAPYENPKLQLGPLDPSGSNYPCQAQTGATFSGTPTEMAKGSKQKMGFTGSAVHGGGSCQISLTYDNPPTAQSAFKVIHSIVGGCPARGVDGNAGNDPNAQAKDEYEFTIPDDIPAGNATLAWSWLNKIGNREFYMNCAPVSITGDGGSKDALNALPDMFIANIAPGGDCKTTEGTDVEFPNPGKSVENNGGKLGKPVGNCGGGAGSGSGSGSGSGSGGAASTPAAGAAAAASTTRRSLHLKIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GZ96</accession>
    <name>A0AAJ0GZ96_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 16">Aurora kinase</fullName>
            <ecNumber evidence="2 16">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B0T15DRAFT_391143</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. Forms a ternary complex with ATG13 and ATG17.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2 16"/>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724688.1">
        <property type="nucleotide sequence ID" value="XM_062864569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GZ96"/>
    <dbReference type="GeneID" id="87883398"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032133">
        <property type="term" value="C:chromosome passenger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051233">
        <property type="term" value="C:spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045143">
        <property type="term" value="P:homologous chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044779">
        <property type="term" value="P:meiotic spindle checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032465">
        <property type="term" value="P:regulation of cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090266">
        <property type="term" value="P:regulation of mitotic cell cycle spindle assembly checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902115">
        <property type="term" value="P:regulation of organelle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072479">
        <property type="term" value="P:response to mitotic cell cycle spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000819">
        <property type="term" value="P:sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14007">
        <property type="entry name" value="STKc_Aurora"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000235">
        <property type="entry name" value="Serine/threonine-protein kinase ark1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 16 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 12 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="43"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12 14">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="121"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="170"/>
            <end position="171"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="13">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU367134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAK3308908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="302" mass="34460" checksum="021BE559D6A93432" modified="2024-07-24" version="1">MEASLHRTAVHRSLQRKSQVQQQPQPPDQQWVSSSQGLHLGQFEIGRPLGKGKFGRVYLVRHRQSGFICALKVLDKAQIARERAEVHVRREIEVHSNLRSPGILGFYNWFHDEKRIFLVLEYAAGGELYKHLRRAGRFPEKRAARYSAQVAAALRYLHSKNVMHRDIKPENILVGLYGELKLADFGYSVHAPSNRRDTLCGTLDYLPPEMVASKRTKYSRAVDQWTLGVLTYEFLTGEAPFEDTPALTTRRIERGDLKPLPASVSAEAKHYVHSLLVLNPTKRLSFDDALAHPWIVKHCGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GZQ3</accession>
    <name>A0AAJ0GZQ3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_525433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724615.1">
        <property type="nucleotide sequence ID" value="XM_062868845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GZQ3"/>
    <dbReference type="GeneID" id="87887674"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3308835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="180" mass="19835" checksum="DCC684F42143AF35" modified="2024-07-24" version="1">MLLLAGRLHYAADSPEPSWPQRPRLLSSFSACSSVWCARTSSRHSLVLPVCSTPGCVIAINQRLLLESTWQVSPPFQAHGRCLSPLLAKHSPGSSDSRPAQAFSKARMPPISSRTEVVQMIYIVPSAVSSVSASLFCLPRELCSFVLLSDILRVPFLLLCSLFFISFAGRRRWSPYVITT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ0GZU0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AhpD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_132198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3309179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724959.1">
        <property type="nucleotide sequence ID" value="XM_062861758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GZU0"/>
    <dbReference type="GeneID" id="87880587"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34846">
        <property type="entry name" value="4-CARBOXYMUCONOLACTONE DECARBOXYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G11590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34846:SF11">
        <property type="entry name" value="4-CARBOXYMUCONOLACTONE DECARBOXYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G11590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxymuconolactone decarboxylase-like" evidence="1">
        <location>
            <begin position="44"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3309179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="206" mass="22537" checksum="2F0051FF981C26B6" modified="2024-07-24" version="1">MRLPYVTNPPAAASPEEEAIVQRIQARRAPRPLQPLDLALLHAPPLADGWNSFLGAVRTRTSLPDDLREIAIARVAVVNRAWYEWMHHAPLAVAGGVSPEGMEVVKREGELVVQLANDDNDGEGKQPTPPPPAGLTEKQWAVLCYADEMTRNVEVKEETFARLKGLFGEREVVEITTTVACYNCVSRFLVALDVGEKNGLGPDAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GZV2</accession>
    <name>A0AAJ0GZV2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_551696</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3309216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724996.1">
        <property type="nucleotide sequence ID" value="XM_062870276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GZV2"/>
    <dbReference type="GeneID" id="87889105"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF22">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11320)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="66"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3309216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="511" mass="56287" checksum="CB820F9FCE227D4B" modified="2024-07-24" version="1">MADEATSHTPAEGHPALTPRSRTDVSDLRAEEKDEADPTSASELDEGDAAGTVSEKALLRKIDWRLLPAVGVLYLLSFLDRSNVGNARIEGLADDLGMTGNQYLTGLTLYFIGYVIFEVPCNIILKRTTPRFWLPTLTVLWGIVATLMGVVQNLEDFFVARFFLGVTESGLFPGTVYYFSMWYKRRERQFRISLFFGAAALAGSFGGILAYGIGHMAGVVWQNGWRWIFILEGIVTVVVAVAAFWFVHNYPDTAKFLSDKERSLVRSRLAADSDATHDEGFTWANVSKALRDPKCWLYGMGFHAMSLPLYTFSLFLPTIIKDLGYTAAKAQLLTIPPYAFAFATTMGVATVSERVGKRAVPLICSALFAIIGYVILLANADPKARPGISYLGTFFAAGGIYPATALSLSWPAINVSGQTKRAVANAMQISIGNLGAVLGTQLYRTETGPRYVVGHSFALGYLVGEVVVSSLLYFVLKRENKRRRHIAPEVNEVGDLADWSGDDDPRWRFQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H0R7</accession>
    <name>A0AAJ0H0R7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11 12">Endo-1,4-beta-xylanase</fullName>
            <ecNumber evidence="4 11 12">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0T15DRAFT_2665</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11 12">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11 12">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 12">Belongs to the glycosyl hydrolase 11 (cellulase G) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="4 11 12"/>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725200.1">
        <property type="nucleotide sequence ID" value="XM_062863411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H0R7"/>
    <dbReference type="GeneID" id="87882240"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.180:FF:000001">
        <property type="entry name" value="Endo-1,4-beta-xylanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018208">
        <property type="entry name" value="GH11_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033119">
        <property type="entry name" value="GH11_AS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033123">
        <property type="entry name" value="GH11_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001137">
        <property type="entry name" value="Glyco_hydro_11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46828">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46828:SF2">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00457">
        <property type="entry name" value="Glyco_hydro_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00911">
        <property type="entry name" value="GLHYDRLASE11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00776">
        <property type="entry name" value="GH11_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00777">
        <property type="entry name" value="GH11_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51761">
        <property type="entry name" value="GH11_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 11 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11 12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11 12" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042565249" description="Endo-1,4-beta-xylanase" evidence="13">
        <location>
            <begin position="17"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="GH11" evidence="14">
        <location>
            <begin position="31"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3309420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="219" mass="23371" checksum="7E93E5AF55E08347" modified="2024-07-24" version="1">MVSLKALLLGAAGALAFPFNVTEMNELVARAGTPSGTGTHNGYFYSFWTDGGGNVNYQNGAGGSYSVQWQNCGNFVGGKGWNPGAARTINYSGSFNPQGNGYLAIYGWTKNPLVEYYIVESFGNYDPSSQASKFGTIQQDGSTYTVAKTRRVNQPSIIGTATFDQFWSVRQNKRTSGSVNVGAHFNAWAKAGLQLGSHDYQIVATEGYQSSGSSSITVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H0X6</accession>
    <name>A0AAJ0H0X6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tyrosinase</fullName>
            <ecNumber evidence="3">1.14.18.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0T15DRAFT_545814</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2 L-dopa + O2 = 2 L-dopaquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:34287"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57504"/>
            <dbReference type="ChEBI" id="CHEBI:57924"/>
            <dbReference type="EC" id="1.14.18.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-tyrosine + O2 = L-dopaquinone + H2O</text>
            <dbReference type="Rhea" id="RHEA:18117"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57924"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="EC" id="1.14.18.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tyrosinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.18.1" evidence="3"/>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725571.1">
        <property type="nucleotide sequence ID" value="XM_062870143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H0X6"/>
    <dbReference type="GeneID" id="87888972"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004503">
        <property type="term" value="F:tyrosinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042438">
        <property type="term" value="P:melanin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016216">
        <property type="entry name" value="Monophenol_mOase_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041640">
        <property type="entry name" value="Tyrosinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF76">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18132">
        <property type="entry name" value="Tyrosinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000340">
        <property type="entry name" value="MPO_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-0470">Melanin biosynthesis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="12">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="13">
        <location>
            <begin position="296"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="429"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="328"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="430"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3309791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="647" mass="71677" checksum="700A053503F1744B" modified="2024-07-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H0Z5</accession>
    <name>A0AAJ0H0Z5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_497803</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725320.1">
        <property type="nucleotide sequence ID" value="XM_062867288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H0Z5"/>
    <dbReference type="GeneID" id="87886117"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3309540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="95" mass="10277" checksum="6A9ADE2A70A93840" modified="2024-07-24" version="1">MPATNTSGPAATYTRGSTNPSWCVNAYENDRSVASQHSLGSLENIRGNPTKVRFTSTCSHKTLVLCYPEPDGKGSVKEAKFDVGSTDEFNTMDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H148</accession>
    <name>A0AAJ0H148_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pyridine nucleotide-disulfide oxidoreductase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_388146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725330.1">
        <property type="nucleotide sequence ID" value="XM_062864428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H148"/>
    <dbReference type="GeneID" id="87883257"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014839">
        <property type="entry name" value="Crt10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08728">
        <property type="entry name" value="CRT10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3309550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="743" mass="82609" checksum="00554D89E2E2C255" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H1M0</accession>
    <name>A0AAJ0H1M0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_27691</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HTATSF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725956.1">
        <property type="nucleotide sequence ID" value="XM_062863532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H1M0"/>
    <dbReference type="GeneID" id="87882361"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12281">
        <property type="entry name" value="RRM1_TatSF1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12285">
        <property type="entry name" value="RRM3_RBM39_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000105">
        <property type="entry name" value="HIV Tat-specific factor 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034393">
        <property type="entry name" value="TatSF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034392">
        <property type="entry name" value="TatSF1-like_RRM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15608:SF0">
        <property type="entry name" value="HIV TAT-SPECIFIC FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15608">
        <property type="entry name" value="SPLICING FACTOR U2AF-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="129"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="325"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="71"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="207"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="272"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="241"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="393"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3310176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="410" mass="46281" checksum="D8BE3A47DD291F18" modified="2024-07-24" version="1">MEAEAEYWTFPTNPEEFDQDDRISYSKLDNKYIAVQEDGTEYEFDAELKRWIPIIDEALIEEQQRGYFMSNADADNDRQGPAQGRKRKIDSNDREQDNNNHSYNHEDRVAKNAKRKQGNRGPPQPKQNTAVYVTGLPPDATAEEVAELFSRKCGVIAEEIDSGRPRIKMYTDADGNFKGDALIVFFKPQSVEMAIMLLDDTDFRFPPPDPNAPKMRVQAADSSYKKVKYDGDNGGGNGDAKSGEGSRPDQRRSDQDKAKIIRKTQKLSAKLADWSDDEPSALHDDNTPGGAMPAKGGKWDRVVILRHMFTLEELQDDPTALLDIKEDIREECSKLGPVTNVVLYDEEEEGIVSVRFQTREAAEACLRVMHGRTFDGRIVEAYFATGREKFRRSKGDAKGGVKDGEHEEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H1P0</accession>
    <name>A0AAJ0H1P0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0T15DRAFT_26491</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725928.1">
        <property type="nucleotide sequence ID" value="XM_062863392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H1P0"/>
    <dbReference type="GeneID" id="87882221"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055122">
        <property type="entry name" value="Med14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013947">
        <property type="entry name" value="Mediator_Med14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809">
        <property type="entry name" value="MEDIATOR COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08638">
        <property type="entry name" value="Med14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26204">
        <property type="entry name" value="Med14_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit MED14 N-terminal" evidence="11">
        <location>
            <begin position="44"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3310148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1026" mass="115975" checksum="F7CF868570566786" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H1U9</accession>
    <name>A0AAJ0H1U9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">4-hydroxybenzoate polyprenyltransferase, mitochondrial</fullName>
            <shortName evidence="11">4-HB polyprenyltransferase</shortName>
            <ecNumber evidence="11">2.5.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Para-hydroxybenzoate--polyprenyltransferase</fullName>
            <shortName evidence="11">PHB:PPT</shortName>
            <shortName evidence="11">PHB:polyprenyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0T15DRAFT_20228</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>an all-trans-polyprenyl diphosphate + 4-hydroxybenzoate = a 4-hydroxy-3-(all-trans-polyprenyl)benzoate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:44504"/>
            <dbReference type="Rhea" id="RHEA-COMP:9514"/>
            <dbReference type="Rhea" id="RHEA-COMP:9564"/>
            <dbReference type="ChEBI" id="CHEBI:17879"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58914"/>
            <dbReference type="ChEBI" id="CHEBI:78396"/>
            <dbReference type="EC" id="2.5.1.39"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Mitochondrion inner membrane</location>
            <topology evidence="2 11">Multi-pass membrane protein</topology>
            <orientation evidence="2 11">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.39" evidence="11"/>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725770.1">
        <property type="nucleotide sequence ID" value="XM_062862585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H1U9"/>
    <dbReference type="GeneID" id="87881414"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008412">
        <property type="term" value="F:4-hydroxybenzoate polyprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13959">
        <property type="entry name" value="PT_UbiA_COQ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1780:FF:000001">
        <property type="entry name" value="4-hydroxybenzoate octaprenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000003">
        <property type="entry name" value="4-hydroxybenzoate polyprenyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1780">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01635">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006370">
        <property type="entry name" value="HB_polyprenyltransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01474">
        <property type="entry name" value="ubiA_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048:SF28">
        <property type="entry name" value="4-HYDROXYBENZOATE POLYPRENYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PRENYLTRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="317"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="341"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3309990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="405" mass="43666" checksum="421023B511560A74" modified="2024-07-24" version="1">MPSCRLLHRLPLRPGTVRYSKPWLPSPRGVSDPRRLALETYKTSLSPPYSLIAYHTTTKLASATTTTTATATAATVAPPPAPEPYRPPRTGLLSYLPPSWVPYAELIRLDKPTGSYYLYFPCLFSTLLAAPLVSPMASPATVLGTSLLFLAGAVVMRGAGCTINDLWDRNLDPHVARTRLRPIARGAVTPFRGVVFTGAQLLTGLAILLQFPTSCFFYATPSLLFVATYPLAKRVTYYPQFVLGLTFSWGAIMGFPALGVDLLSNGTAQAAAALLYTSNVAWTVLYDMIYAHMDIKDDAKAGIKSIALKHDKETKQVLTGLALTQVALLAGAGIATGAGPAFFVGSCGGALVTLGIMIKRVNLKSVKNCWWWFVNGCWITGGVISLGLAADYLVRYAHRDNEEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H267</accession>
    <name>A0AAJ0H267_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_507150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726257.1">
        <property type="nucleotide sequence ID" value="XM_062867630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H267"/>
    <dbReference type="GeneID" id="87886459"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021514">
        <property type="entry name" value="DUF3176"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394:SF5">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11374">
        <property type="entry name" value="DUF3176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="847"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="242"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3310477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="961" mass="103297" checksum="A88CCBD4F2D519AE" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H286</accession>
    <name>A0AAJ0H286_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutathione S-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_518634</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726259.1">
        <property type="nucleotide sequence ID" value="XM_062868378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H286"/>
    <dbReference type="GeneID" id="87887207"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03048">
        <property type="entry name" value="GST_N_Ure2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF23">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-LIKE PROTEIN TPCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01151">
        <property type="entry name" value="Main.2:_Nu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="3">
        <location>
            <begin position="7"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="4">
        <location>
            <begin position="95"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3310479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="234" mass="26417" checksum="A5AE60D858FF8671" modified="2024-07-24" version="1">MSAQSNLKPIKVYGKGGPNPPKVAMILQELDLPHEIIDIQFSELKKPDYLAVNPNGRIPAIYDPNTDLTLWESGAILEYLIEKYDKAQKLSFPPGSKEAYHAKQWLFFQTTGQGPYYGQGVWFNKYHPEKVQSAIERYLNEVKRVTGVIEGHLAKQKKQYGAQEGFDGPWFVGNKLSYVDFAFVPWQTVAAGYFAEALPDGLKFNPDDYPLVKEWLAKLRARKSVSSSLSLPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H3J7</accession>
    <name>A0AAJ0H3J7_9PEZI</name>
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        <recommendedName>
            <fullName evidence="5">DUF1275 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_507677</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726862.1">
        <property type="nucleotide sequence ID" value="XM_062867662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H3J7"/>
    <dbReference type="GeneID" id="87886491"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010699">
        <property type="entry name" value="DUF1275"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488:SF1">
        <property type="entry name" value="DUF1275 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488">
        <property type="entry name" value="DUF1275 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06912">
        <property type="entry name" value="DUF1275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3311082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="29780" checksum="D033D4BA61E91655" modified="2024-07-24" version="1">MPGNGVVSDEETPLLRNRSTKPSVSRWRRHLTADVSRKHVDVILLLCYLITGLLDSASISVWGSFVSMQTGNSVYFGLGLASPSESTRWIKSGVSLLAFCVGSVVFSRFHRFFSPKRRWVLCTSFIFQTILTSVAAAIVTFTTATGSPAGATAGDQKTTTIGWHVLLPIALVAFQACGQAVVSRALRYNALTSVVLTSIYCDLFSDADLFALRNVERNQRTAAPLLLLLGAFLGGKFAHSVLGVAGALWTAAVLKAMVVVVWIVWPSDGEAPREGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H3P3</accession>
    <name>A0AAJ0H3P3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosome biogenesis protein NSA2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_389519</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the pre-66S ribosomal particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726996.1">
        <property type="nucleotide sequence ID" value="XM_062864498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H3P3"/>
    <dbReference type="GeneID" id="87883327"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11381">
        <property type="entry name" value="NSA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.310:FF:000001">
        <property type="entry name" value="NSA2, ribosome biogenesis homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039411">
        <property type="entry name" value="NSA2_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_Se8/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12642">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NSA2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 8" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3311216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="254" mass="28666" checksum="BB978AF33EF88115" modified="2024-07-24" version="1" fragment="single">ERHRKLHGKRLDHDERARKKAAREGHKQSENAQNLRGLRAKLYAKQRHAQKIQMRKAIKQHEERNIKGAPAEKEPSDPVPAYLLDRANPTTAKALSSQIKNKRAEKAARFSVPIPKVRGISEEELFKVVKTGKKTQKKGWKRVVTKPTFVGPDFTRRPVKYERFIRPMGLRYKKANVTHPTLNVTVQLPILGVKKNPSNPLYTQLGVLTKGTIIEVNVSDLGIVTASGKIAWGRYAQITNNPENDGCLNAVLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H3X5</accession>
    <name>A0AAJ0H3X5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_68508</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727057.1">
        <property type="nucleotide sequence ID" value="XM_062871208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H3X5"/>
    <dbReference type="GeneID" id="87890037"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="3">
        <location>
            <begin position="247"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="1">
        <location>
            <begin position="247"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="55"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="294"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="302"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3311277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="318" mass="35371" checksum="BFB2EF2C01AAEC1F" modified="2024-07-24" version="1">MLSAIRRATAGQVRLGGELAIRSASRIAVRFAAPQLMPVVPSGIRVAAVFARGYAGRGRPKGSTTKTSTSAEAKKKPASKTGRAKKTGTAKKTAAAKKAPTKAKKPQKKPAEKPARRPKRELTEEQKTKLEIRDLKKKALVREQPKGLPDKPWSVFTAQRLRAAGRMEGLEVMMPQISVDFKALPSDEVEKLNAIAQQNKVANQVKFQNWIDSHTPQEIRAANLARLQLRRKHGITKYRSIPDARYPKQNLTPFVAFVKSRFPSMADDPSHAKDKLMKIAVEWKGLSAEERKPFHEIAATDTARRQKELDAYREQGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H3X8</accession>
    <name>A0AAJ0H3X8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Structural maintenance of chromosomes protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0T15DRAFT_521183</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727141.1">
        <property type="nucleotide sequence ID" value="XM_062868549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H3X8"/>
    <dbReference type="GeneID" id="87887378"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001301">
        <property type="entry name" value="Structural maintenance of chromosomes 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecF/RecN/SMC N-terminal" evidence="12">
        <location>
            <begin position="89"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="268"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="370"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="697"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="833"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="921"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3311361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1129" mass="129103" checksum="F33DC91D19263B7A" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H409</accession>
    <name>A0AAJ0H409_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MAGE family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_74480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727189.1">
        <property type="nucleotide sequence ID" value="XM_062871269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H409"/>
    <dbReference type="GeneID" id="87890098"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1200">
        <property type="entry name" value="MAGE homology domain, winged helix WH1 motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1210">
        <property type="entry name" value="MAGE homology domain, winged helix WH2 motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037445">
        <property type="entry name" value="MAGE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041898">
        <property type="entry name" value="MAGE_WH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041899">
        <property type="entry name" value="MAGE_WH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002190">
        <property type="entry name" value="MHD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11736">
        <property type="entry name" value="MELANOMA-ASSOCIATED ANTIGEN MAGE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11736:SF14">
        <property type="entry name" value="NSE3 HOMOLOG, SMC5-SMC6 COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01454">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01373">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MAGE" evidence="2">
        <location>
            <begin position="55"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3311409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="328" mass="36544" checksum="D389494C5B49ED08" modified="2024-07-24" version="1">MPPQQRRRRQAVQDDEDEDMQQQALQSEDDADNDGDTRMDDVGHRDERSQMIKNLVRYALACEYSRAPIRRDGIREKVLGPNNGRLFKKVFAGAQRQLRATFGMEMVELPTKDRNLMTAEQKRKAAKSQSQKEPSSNAYVLVSVLPEAYRTPAIITPSKIQSADGEASYVALYTMIIAIITLSGGELSEPRLRRHLTRLNAVENMPGMNPNDGTSPNEKTDLVLQRMVKQGYLVKVTESKAMGDDDSTTWHVGPRGKVEVGPEAIAAFVRTVYGGSNDELEKKLQVSLKIRERKPGIPETVGEDAEDADRAPPDGDPGPSNRRRGRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H455</accession>
    <name>A0AAJ0H455_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_66839</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726999.1">
        <property type="nucleotide sequence ID" value="XM_062871178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H455"/>
    <dbReference type="GeneID" id="87890007"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033316">
        <property type="term" value="P:meiotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000131">
        <property type="entry name" value="Dual specificity protein kinase TTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974:SF21">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE TTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974">
        <property type="entry name" value="MIXED LINEAGE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="488"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="66"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="323"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="438"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="115"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="169"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="244"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="323"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="370"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="392"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="516"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3311219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="806" mass="88060" checksum="4A93EF521EF8C31A" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H468</accession>
    <name>A0AAJ0H468_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_520762</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO1/REXO3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726980.1">
        <property type="nucleotide sequence ID" value="XM_062868523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H468"/>
    <dbReference type="GeneID" id="87887352"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06145">
        <property type="entry name" value="REX1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000019">
        <property type="entry name" value="RNA exonuclease NEF-sp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034922">
        <property type="entry name" value="REX1-like_exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF115">
        <property type="entry name" value="FI18136P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="8">
        <location>
            <begin position="317"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="22"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3311200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="705" mass="77298" checksum="DFA492BEBA2BFB9F" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H488</accession>
    <name>A0AAJ0H488_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_521853</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727337.1">
        <property type="nucleotide sequence ID" value="XM_062868581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H488"/>
    <dbReference type="GeneID" id="87887410"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF4">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_7G04540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3311557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="357" mass="38285" checksum="E451B358F60ED11D" modified="2024-07-24" version="1">MTCTVATRLLRPTQYLARTTRTLTSASRFFEAPTVSVPPRTSTANPITPPPTRTFSSVKMSKSVAAASHADFHRASLFDLKGRVALVTGGGSGIGLMITQALAVNGAKVYIVGRTGEKLDTVVSTYNKDIEGEIIPLQGDVTKKEDVARLVKEIESREQCLCILVNNAGVSSNTVQPESGSAAEMKQNLFDTDKTTAKDWTDTYEGDVVSIYFMTSAFLPLLQKSSERHPHWSGTVINITSISGLVKGAQHHFAYNAAKAAATHLTRMLAGEIASAGHKIRVNALAPGVFPSEMTAGESDEYQKSHLEKSKYEGKVPAGRPGRDIDMAQGVLSLACNQYIDGQTLVVDGGYTLSMGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H4F2</accession>
    <name>A0AAJ0H4F2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_521883</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727351.1">
        <property type="nucleotide sequence ID" value="XM_062868587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H4F2"/>
    <dbReference type="GeneID" id="87887416"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF63">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03520)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3311571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="287" mass="30618" checksum="A8C66F72D105C68C" modified="2024-07-24" version="1">MASSGILAGRLAGKNCLITGAAGGIGLETSILFAKEGANVLMTDVSNEALMTAFGKVGHLVPNCNRIEWRVCDVSKEADVKGAIEHLDDWGGLDVIFNNAGIMHACDDDAVNTPENIWDLTMNINVKGVWYGCKHAVLALRRHDKKKGSIINTASVVALVGSATPQLAYTASKGAVLALTRELAIVHAREGFRFNALCPAPLNTPLLQDWLGDDQAKRHRREVHFPTGRFGEAVEQAQAVLFLASDESSFVNGTDFVVDGGMTKAYVTPEGPAAPAPVNNALKDRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H561</accession>
    <name>A0AAJ0H561_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_82858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727465.1">
        <property type="nucleotide sequence ID" value="XM_062871360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H561"/>
    <dbReference type="GeneID" id="87890189"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3311685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="350" mass="39068" checksum="17502B0F4F0B5C8F" modified="2024-07-24" version="1">MAQVPCSSHINAEVKGLYAANGGLLNAKIKIDNSRHQYICFINGRYTPEEALQFLHPDIEKYAWIVNAIPSPSDEPIPLPLQDTAVTAPLENGNNKPSASRQADSEQHLRDIANATALFSMLEGHEDDYSRCRRDCDLDDTEPFSDAFYEDCLEAHEADIRSALTQWLASPSQSVLLTIDGTEYTHRQRWPTRFAVEAVHDAQWRKQQVCHCFCGEQPDDVGSWPSLVVRHLLAQLPAVRGAKNGSARQRKRGGVELDCAQIPASVLWAAFKDRMAQADINSVTIVLDEIDALYDRCNDHDEGVKRFADFVHGLSWLMRSGPVLRVMVTSWSSEVLDVIRNGVATELLGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LYK4</accession>
    <name>A0AAJ0LYK4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">TATA-binding protein-associated factor mot1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Modifier of transcription 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NCT transcriptional regulatory complex subunit mot1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">B0T15DRAFT_562125</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Regulates transcription in association with TATA binding protein (TBP). Removes TBP from the TATA box via its C-terminal ATPase activity. Both transcription activation and repression require its ATPase activity. Part of the NCT transcriptional regulatory complex that acts as a key regulator of ergosterol biosynthesis and the azole exporter cdr1B. The NCT complex binds the promoters of genes linked to azole susceptibility, and especially represses the expression of cdr1B transporter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Forms the NCT transcriptional regulatory complex with nctA and nctB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718138.1">
        <property type="nucleotide sequence ID" value="XM_062870567.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87889396"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17999">
        <property type="entry name" value="DEXHc_Mot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000009">
        <property type="entry name" value="B-TFIID TATA-box-binding protein-associated factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000508">
        <property type="entry name" value="Probable helicase mot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000445">
        <property type="entry name" value="Related to MOT1-transcriptional accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000428">
        <property type="entry name" value="TATA-binding protein-associated factor 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044972">
        <property type="entry name" value="Mot1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044078">
        <property type="entry name" value="Mot1_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022707">
        <property type="entry name" value="Mot1_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36498">
        <property type="entry name" value="TATA-BINDING PROTEIN-ASSOCIATED FACTOR 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36498:SF1">
        <property type="entry name" value="TATA-BINDING PROTEIN-ASSOCIATED FACTOR 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12054">
        <property type="entry name" value="DUF3535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="1313"/>
            <end position="1486"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="1658"/>
            <end position="1809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="178"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="695"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="721"/>
            <end position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00053370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00064550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00073046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00081280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00081329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAK3302358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1955" mass="217349" checksum="477C8A7FD0388DAC" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2025-04-02" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LYL3</accession>
    <name>A0AAJ0LYL3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nucleoporin Nup186/Nup192/Nup205</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_440833</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NUP186/NUP192/NUP205 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718230.1">
        <property type="nucleotide sequence ID" value="XM_062865910.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87884739"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021827">
        <property type="entry name" value="Nup186/Nup192/Nup205"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11894">
        <property type="entry name" value="Nup192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="565"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1672"/>
            <end position="1691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3302450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1744" mass="195464" checksum="30A426AB4961EF89" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LYN1</accession>
    <name>A0AAJ0LYN1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_562471</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718347.1">
        <property type="nucleotide sequence ID" value="XM_062870579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LYN1"/>
    <dbReference type="GeneID" id="87889408"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF9">
        <property type="entry name" value="MEAB PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="5">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="159"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="281"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="67"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="199"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="336"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3302567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="379" mass="40978" checksum="8C456DC52FF567D6" modified="2024-07-24" version="1">MSVDKKDPSKDDSEDSMESSPEGEAPPAPPQQPAENQQPKRKGGRKPIYATSEERKQRNRQAQAAFRERRTEYIKQLEEAIRTHEQNLANLQAAHRHAADECLMLRYKNSLLERILLEKGIDVQAELRAKTGSPNLGPTHVPQNLVQPPPIQRAILNRHHARRSQSGIAPKLEPGIPVSPLPPPIQPNPSALSPRHRQTPSSHSGSPAGTTSFGSQHGASPAASDQMNPPVRPSMPPVTAMKAPPPHLAPLHGLPGIRQMQNHIEQLGKLAQQEYDAAADMMEDPGDTPDTPSGPGPYPGPSYAGEPQPMSLASPVSTGPPAGHTIAGQSPIDHGANSQQPTYPSMTQLLDPSYDFDPFGLSASMAFPTQFSFDTSNMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LYR6</accession>
    <name>A0AAJ0LYR6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_577730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718452.1">
        <property type="nucleotide sequence ID" value="XM_062871071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LYR6"/>
    <dbReference type="GeneID" id="87889900"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3302672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="274" mass="29148" checksum="2EB182F8392B4F52" modified="2024-07-24" version="1">MSDTSSSGGYQSSDDYPESILDTLEASLTTNRGEESTEQSSLPFHAPRLNQPGAMQQLGHLHVRHVDNAVAGSANNNIQALAPAPIPDQLIDPILHEYQAIADKANAARPPSPWGGRMLASVEYEPRRARRAAYDAAQAELAHVQARPAAFLEAEARSQAAAATNTHSQPSPNQAQAASDNENNRRHEPAAPRGQGERAQRNATLHALGLCVHCRRPNVPGSKKKGCPECRAKRAKLTNAWRDKTSRGQGPGSGGPGSQGPPPPPRDGAVVKFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZT1</accession>
    <name>A0AAJ0LZT1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_496256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719505.1">
        <property type="nucleotide sequence ID" value="XM_062867167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZT1"/>
    <dbReference type="GeneID" id="87885996"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3303725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="74" mass="7835" checksum="C34DDF281CC8BC94" modified="2024-07-24" version="1">MPTVEPPRQQAPMEAALTSSASAPGRTSAEIITQQPKSEPRPQPENDLHLRGGSMTIGCNCCGGSLSCHRVCCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZX1</accession>
    <name>A0AAJ0LZX1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_285932</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719625.1">
        <property type="nucleotide sequence ID" value="XM_062863633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZX1"/>
    <dbReference type="GeneID" id="87882462"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF37">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3303845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="508" mass="59303" checksum="CDDA8C7D412DA0FD" modified="2024-07-24" version="1">MTAPATLDVQGRPMTYEEAAEEEFNVLSRLGHSAALKTLADDLWRHRKSIEGLTRHHLGLGKHDTCDVLERRHWIRGGFNMCVLLNITSPGRQERKVVFRCAMPHKLAEARYPGTVDEKLGCKVGSYVFIQENCPNVRIPHLYGFGFSDSRQFTHVCHRPFLVRISHMFRRCIYRLFDRVLSQYTCNATHHSVPFAYLLLDRINPKSGQMLSNTWDKYRDDPARRQRLFRGMAKIMLSLARLPQMQIGSFQFNDDGTLTLRNRPLTCSMSLLENDGAPRTMQRSDTYKCTDAFVADMITFHDQRFLHQPNSVNSETDCRSQMAVMTLLRVFSHRFIKREHRYGPFLLQLTDLHASNLFVDDDWNVTCLIDLEWLCALPREMLDVPYWLTGCSIDQIQDDRYVEFDKIRREFMHVFEKEERTMAAEQGLTITVSSVMQEMWDSNGTWFWRCLSSVNAMYLLLEDHLCPGRLPVSVEEAVSQFWCEDPDAVVRAKLADKERYDELLRQEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZZ4</accession>
    <name>A0AAJ0LZZ4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_417612</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3303920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719700.1">
        <property type="nucleotide sequence ID" value="XM_062865495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZZ4"/>
    <dbReference type="GeneID" id="87884324"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43039">
        <property type="entry name" value="ESTERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="307"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3303920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="566" mass="61931" checksum="990AAAE87BE75838" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M025</accession>
    <name>A0AAJ0M025_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heterokaryon incompatibility Het-C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_568055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719801.1">
        <property type="nucleotide sequence ID" value="XM_062870744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M025"/>
    <dbReference type="GeneID" id="87889573"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010816">
        <property type="entry name" value="Het-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052577">
        <property type="entry name" value="VWA7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905">
        <property type="entry name" value="NG37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905:SF7">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07217">
        <property type="entry name" value="Het-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042515776" evidence="2">
        <location>
            <begin position="29"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="585"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="622"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="649"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="688"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="729"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="740"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3304021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="763" mass="82418" checksum="ECB781FFD4B676A0" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M095</accession>
    <name>A0AAJ0M095_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA-processing protein 42</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_233108</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719999.1">
        <property type="nucleotide sequence ID" value="XM_062862974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M095"/>
    <dbReference type="GeneID" id="87881803"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF8">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0271">Exosome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="76"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3304219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="386" mass="41245" checksum="A68AEB4564DBD27C" modified="2024-07-24" version="1">MASSQHVLLSPAELAYLHASLSLTPPIRPDGRTPTQFRPLAAETGILPGTNGSARICFADGTEAIVGVKAEVERTAQRAGEETTFTEGNFGGDEDEDVEDGEAKEGVDKRRGDSSWVEMTVEIPGLRDDDSGTAFLAAMLSEALLADGEFVKRLWINRRFHWKLYLDIILISPPLSYPLPLLSLTTHLALLSTRLPRLKSEGDEDPFFDDDWAAAPYLFPRSVTASAQSTAEDPTASRPPITLLVMAVGNNIIFDPSKEELAVADVALAVSVTGTTPHAEDTVQAEGKVGRNLRLLSIRTIDPPSRLTPPGVANAANAAYGTANGAATQQKMLEARTAETEVVEGVWKAPRGGAKRMVLGALVQKVLERGGVVDEVLDALEGVDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M0C5</accession>
    <name>A0AAJ0M0C5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="12">1.2.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0T15DRAFT_399050</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = (2R)-3-phospho-glyceroyl phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10300"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.12" evidence="12"/>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720089.1">
        <property type="nucleotide sequence ID" value="XM_062864987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M0C5"/>
    <dbReference type="GeneID" id="87883816"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18126">
        <property type="entry name" value="GAPDH_I_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05214">
        <property type="entry name" value="GAPDH_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000001">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000020">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836">
        <property type="entry name" value="GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836:SF76">
        <property type="entry name" value="GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 9 12" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding" evidence="13">
        <location>
            <begin position="4"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="13"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="151"/>
            <end position="153"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="211"/>
            <end position="212"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="10">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3304309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="339" mass="36464" checksum="8C62A267C9DB2344" modified="2024-07-24" version="1">MAPIKVGINGFGRIGRIVFRNAVEHPDVQIVAVNDPFIEPKYAEYMLKYDSTHGVFNGTISVEGNDLIVNGKKVKFYTERDPANIPWKETGAEYIVESTGVFTTTEKAKAHLQGGAKRVIISAPSADAPMYVMGVNEDKYDGSAQVISNASCTTNCLAPLAKVVHDKFGIVEGLMTTVHSYTATQKTVDGPSSKDWRGGRGAAQNIIPSSTGAAKAVGKVIPDLNGKLTGMSMRIPTANVSVVDLTCRLAKEASYDEIKAAIKEAADGPLKGVLAYTEDEVVSSDLRGHPASSIFDAKAGISLNKNFVKLISWYDNEWGYSRRVLDLLAYVAKVDAGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M0L9</accession>
    <name>A0AAJ0M0L9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase II subunit RPB3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_437142</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720390.1">
        <property type="nucleotide sequence ID" value="XM_062865844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M0L9"/>
    <dbReference type="GeneID" id="87884673"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07031">
        <property type="entry name" value="RNAP_II_RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.120.12:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="entry name" value="DNA-directed RNA polymerase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00320">
        <property type="entry name" value="RNApol_arch_Rpo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001514">
        <property type="entry name" value="DNA-dir_RNA_pol_30-40kDasu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022842">
        <property type="entry name" value="RNAP_Rpo3/Rpb3/RPAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050518">
        <property type="entry name" value="Rpo3/RPB3_RNA_Pol_subunit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001988">
        <property type="entry name" value="PRK00783.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800:SF2">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00446">
        <property type="entry name" value="RNA_POL_D_30KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RpoA/D/Rpb3-type" evidence="9">
        <location>
            <begin position="27"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="304"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00072506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3304610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="338" mass="36579" checksum="6B56C6A381D7E4DE" modified="2024-07-24" version="1">MDYDPMVMDDAEAMGPVVKISQADSVRVKYQLANADISFANSLRRVMLAEIPTLAIDLVEIEENSSVLADEFVAHRLGLIPLNSEGVDSMFFSRDCDCDSTCERCTVTLTLHAKCTGDENMHVFARDLVPTSERINSVLGNPIISDPDGLGPLILKLRPGQEVKLVCIAKKGIAKEHAKWAPSAAIGFEYDPHNKLHHIDLWYEQDAKAEWPPSEYAEWEEPPQEGEPFDYDAVPNRFYFNVESAGSLPPDVIVSEGIKVIQQKLAGLIHELSEGDGGDGMNGDYGGPRSPEYATGADGFGGYTTPFGNGGNQSSWGGAGGTTPYGTTPYGGGQSSWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M1E8</accession>
    <name>A0AAJ0M1E8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_398084</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721214.1">
        <property type="nucleotide sequence ID" value="XM_062864935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M1E8"/>
    <dbReference type="GeneID" id="87883764"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38701">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38701:SF1">
        <property type="entry name" value="UP-REGULATED DURING SEPTATION PROTEIN 1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="454"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="633"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="417"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="207"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="260"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="365"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="454"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="499"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3305434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="659" mass="70252" checksum="39FC8FFD4230C57A" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M272</accession>
    <name>A0AAJ0M272_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7587 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_573361</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722126.1">
        <property type="nucleotide sequence ID" value="XM_062870925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M272"/>
    <dbReference type="GeneID" id="87889754"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056009">
        <property type="entry name" value="DUF7587"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24494">
        <property type="entry name" value="DUF7587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7587" evidence="2">
        <location>
            <begin position="212"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3306346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="367" mass="42235" checksum="AE77E51CBD5A694D" modified="2024-07-24" version="1">MESYAPEEDTQMTGPGDEKQIRNAETTFEEPEHGRQTQKAQRKSQLKKQIILESVRKMEGRHLDKAIAIMEKEIRRTKKAAEKLEELDGKRVAEPAVTTAAESRPFDVEESKRMSEKDHGRRVTDSKDDAESNDPTLGELCGLLGLPDSEISPGRGACKIGYPLHPKTRVATLGTLGLASRPRYVYRVVHNAMPFRGHKARGYGRVVADPLIFQLYLQKHLFWASRWQSPFLSVATTMEKVLEFTGIFWYQGHYGIKIYTIDTHLDARNHTRQPMFDVSELIWELGLPRRGNLFEEECVVMHSIPEACVVKTMEWDEIWRTHKKTLMEIGKSQKMKPKGGPSQEWLEERRRLYGVNSRRLLPFHVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M286</accession>
    <name>A0AAJ0M286_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Regulatory P domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_417125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3306049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721829.1">
        <property type="nucleotide sequence ID" value="XM_062865484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M286"/>
    <dbReference type="GeneID" id="87884313"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027589">
        <property type="entry name" value="Choice_anch_B"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04312">
        <property type="entry name" value="choice_anch_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38787">
        <property type="entry name" value="REGULATORY P DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38787:SF1">
        <property type="entry name" value="REGULATORY P DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042524692" description="Regulatory P domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3306049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="478" mass="51824" checksum="4EFA0BA4241D5658" modified="2024-07-24" version="1">MKINTLASLTAILAASAAAADSAAASAQSAASGKMEKVMEIKTKQWDAARARGLFGGSALYRKITSKKTCKKGKAGSGNDAYACNNVDLHGFLSHEDLGSATKAGNDVWGWTSPGGREFGIVGQTDGVGFVEVMKNGNLEYLGRLDTQTTPTSWRDIKVIGHHAYIGSEADGHGLQIFDLNKLLDVKPWWNPVFWTPKTFSKEKDITLFSGFGASHNIVAHAETNMIYAVGGRSGANARNTTCAGGMFMVDVSNPEKPVSPGCIAQDGYVHDAQCVIYKGPTDKYLGREICFNYNEDTLTIMDVTDKASPAIVSRTPYVGFAYTHQGWLVDDSMTFLLLDDELDEMEGTDPGSDGHTTTYIFNITNLEAPVNTGHYKSPAKSIDHNQYVVNGLTYQANYGSGLRIVDVSGVELDPTGGNFAEVGFFDCHPEDDDVNGVVEFLGTWSVYPYFKSGYILLNSIERGIFSLKYTGRKAKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M2D2</accession>
    <name>A0AAJ0M2D2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Endonuclease/exonuclease/phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_142928</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Probably binds two magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722280.1">
        <property type="nucleotide sequence ID" value="XM_062861903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M2D2"/>
    <dbReference type="GeneID" id="87880732"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008311">
        <property type="term" value="F:double-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="AP ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748:SF14">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="9">
        <location>
            <begin position="47"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="212"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="425"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="424"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="425"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="7">
        <location>
            <position position="394"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA substrate" evidence="7">
        <location>
            <position position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3306500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="445" mass="49828" checksum="7B60DDF55AEB82B3" modified="2024-07-24" version="1">MMNRDISPPPAKRRRVAPAAISAFTDSESKGKITKEDMRLPSIRLFSWNINGIGPLLPSQTTRITSFFKPLNGDWDNSPAAGQPKLNGLRAFLSRHNWPEVLFLQELKIAEGDSKTLAALLSALNTPSSAEGDKAPADTRTYTLDAALPRDRFNVRGFQGKLYGVGTILRTDFAREHVARVRDVDWDREGRVSIVELKNKKKKKRRLTQSQQHEHDNDDTTDAEDYRRPLALINVYAVNGTSAPYRSPRDGGRAVGTRHDHKRAFHSRLRDECLALEARGFHVVVAGDVNVARGRLDGYPNLRSFPREHCANRADFNVKFFGPEDNARAQAYCGVHDKEGGDGEKEEEKEEQKEKEKERCLDAVDVFRAMHGAERRYTYYPRSGEWGSSCDRVDMVFVSKGLWGAGQVLGTGILDTPQERGLSDHVPLWVEIAMAGSVNRASEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M3B1</accession>
    <name>A0AAJ0M3B1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arf-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_433088</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723285.1">
        <property type="nucleotide sequence ID" value="XM_062865762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M3B1"/>
    <dbReference type="GeneID" id="87884591"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048205">
        <property type="term" value="P:COPI coating of Golgi vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08831">
        <property type="entry name" value="ArfGap_ArfGap2_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000013">
        <property type="entry name" value="Putative Arf GTPase-activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686:SF4">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="8"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="139"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="276"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="189"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="290"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3307505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="507" mass="53926" checksum="04B17CAAFFE57548" modified="2024-07-24" version="1">MSGLASKQESLKIFEKLKAKPANKICFDCGQKNPTWTSVPFGIYLCLDCSANHRNLGVHISFVRSTNLDQWQWDQLRIMKVGGNESATKFFQSNGGSAALNSKDPKTKYTSAAATKYKEELKKRAARDAKEYPEEVVINDGGEGAEGGETPAEEDDDFFSSWSKPAVKKLSPPISRTATPPVVGRTPSPFLNAQNGKDTGRSPSPLANNSEGESKPSRITTSAALRSNTTGPRKANILGAKKATSKLGAKKLGADAAIIDFDEAEKKAKEEAERIEKLGYDPNAEEEASAAKPAAGKSDSSAAIISPTPVSPARGGYGSSHSREKSAAEMERLGMGIGRLGFGQVGKPAAAQKSAGGFGSVGPIKASSTEGKFSFFPTRHHHHSGSLLTAETDEGENYARKKFGNQKAISSEEFFGKGRFDPAATAEAKNRLQGFEGAQAISSNAYFGRPETEEGASVDDYGDLESAAKDFVRRFGITAADDLENLTHLLGEGAGRLQGAIRAYLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M3Q7</accession>
    <name>A0AAJ0M3Q7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_522794</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3307848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723628.1">
        <property type="nucleotide sequence ID" value="XM_062868648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M3Q7"/>
    <dbReference type="GeneID" id="87887477"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051631">
        <property type="entry name" value="Ankyrin-KH/SAM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23206:SF8">
        <property type="entry name" value="ANKYRIN REPEAT AND KH DOMAIN-CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23206">
        <property type="entry name" value="MASK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="87"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3307848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="211" mass="23691" checksum="461ADE821C4C116F" modified="2024-07-24" version="1">MPFVAGEVDVINELLPRHTKDELERDSLRQINEHRTVRPSSCSTLDTAPRLLMRIPILLCAGQHVHNTMLTQLLISRRFPLEARDCDGRTRLLLSARDGSYGAVQVLIDSGVDIEVARNDGGTPLSTAIYQERPRIVRFLLEKGAKRALPGPLKDEAGTMLEYATTPVRRKEIGKTRSQHPRLSVLSSNTGLQFSSRYEYICLLDEPPPHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M3S1</accession>
    <name>A0AAJ0M3S1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamine synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_549879</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3307970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723750.1">
        <property type="nucleotide sequence ID" value="XM_062870231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M3S1"/>
    <dbReference type="GeneID" id="87889060"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.10:FF:000013">
        <property type="entry name" value="Related to fluG protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43383:SF2">
        <property type="entry name" value="AMIDOHYDROLASE 2 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43383">
        <property type="entry name" value="NODULIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS catalytic" evidence="4">
        <location>
            <begin position="549"/>
            <end position="883"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3307970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="883" mass="98794" checksum="2A759D43306D7A83" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M3U1</accession>
    <name>A0AAJ0M3U1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Trehalase</fullName>
            <ecNumber evidence="8">3.2.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Alpha-trehalose glucohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_482873</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="3.2.1.28"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the glycosyl hydrolase 37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="8"/>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723806.1">
        <property type="nucleotide sequence ID" value="XM_062866131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M3U1"/>
    <dbReference type="GeneID" id="87884960"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005993">
        <property type="term" value="P:trehalose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000026">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001661">
        <property type="entry name" value="Glyco_hydro_37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018232">
        <property type="entry name" value="Glyco_hydro_37_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011120">
        <property type="entry name" value="Trehalase_Ca-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403:SF6">
        <property type="entry name" value="CYTOSOLIC NEUTRAL TREHALASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01204">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07492">
        <property type="entry name" value="Trehalase_Ca-bi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00744">
        <property type="entry name" value="GLHYDRLASE37"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00927">
        <property type="entry name" value="TREHALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00928">
        <property type="entry name" value="TREHALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Neutral trehalase Ca2+ binding" evidence="10">
        <location>
            <begin position="97"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3308026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="749" mass="86111" checksum="1A32ECBDDE6C5FEB" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M474</accession>
    <name>A0AAJ0M474_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-conjugating enzyme E2 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_490949</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724138.1">
        <property type="nucleotide sequence ID" value="XM_062866737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M474"/>
    <dbReference type="GeneID" id="87885566"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14311">
        <property type="entry name" value="UBA_II_E2_UBC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23800">
        <property type="entry name" value="UBCc_UBE2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015368">
        <property type="entry name" value="UBA_C_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09288">
        <property type="entry name" value="UBA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="9">
        <location>
            <begin position="4"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3308358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="235" mass="26167" checksum="94CADE881C1E7A8C" modified="2024-07-24" version="1">MATTRERRIAKELADIHNDKDNSGVFAHPVDPSNLTHLKGTFPGPPDTPYAGGKYEIDIIIPDMYPFKSPIMKFDTKIWHPNVSSVTGAICLDTLGTGWSPVGTIKMALISLRMLLESPNPKDPQDAEVAKMMMEHPDEFARKAHDWAVKYAGAPRQAILTHNYQATPPPVAKNDPSRYQGYNKDLVDRFVNMGFDVDAVVEAFLYVGIDRNGGEDYELEEAYMGDITARLLGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M4H8</accession>
    <name>A0AAJ0M4H8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aconitase/3-isopropylmalate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_108963</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724275.1">
        <property type="nucleotide sequence ID" value="XM_062861469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M4H8"/>
    <dbReference type="GeneID" id="87880298"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050075">
        <property type="entry name" value="LeuD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43345:SF2">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDRATASE SMALL SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43345">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDRATASE SMALL SUBUNIT 2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="2">
        <location>
            <begin position="7"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3308495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="152" mass="16501" checksum="0D546B238F4D990E" modified="2024-07-24" version="1">MAEVCMENYDKAFGSIAQAGDILVSGFNFGCGSSREQAATAILAKKIPLVVAGSFGNIFSRNSINNALMGVEVPRLVQRLRETFGGKDGEKTLTRRTGWKLVWDVRRSKVTVTEGEGGKTWSQKVGELPPNVQEIIARGGLENWVKSQIAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M5J0</accession>
    <name>A0AAJ0M5J0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_488306</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725367.1">
        <property type="nucleotide sequence ID" value="XM_062866495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M5J0"/>
    <dbReference type="GeneID" id="87885324"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF84">
        <property type="entry name" value="FUNGAL SPECIFIC TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="11"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3309587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="283" mass="31513" checksum="76CB1182C8398E2A" modified="2024-07-24" version="1">MTSEASSNNPACVECKRRKQGCDRHFPCGHCVKRKVAHLCTFRASDSRTPNDQRSNDSQSRLGPQVRHCFCVSADNSAAVSPLSTHGKRRLESQDDVAPPNGDSEHDDASDINVSDALNCLGYMPFHHAVVLGQGPGPKTGRDLVEETDVEQSEELKETLRLMPKRGLIDVLVDNFLDGANYHYYALYSEAFRNQYRGWCAKSQDKVTPELTSLILRVCTCSLHLIIGDRVREQLEELQTDVLTYANRMHVLAQKLSASIGPGKAGLVHIQQPFLTAFWFKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M5N1</accession>
    <name>A0AAJ0M5N1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Galactosyl transferase GMA12/MNN10 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_545892</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725594.1">
        <property type="nucleotide sequence ID" value="XM_062870146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M5N1"/>
    <dbReference type="GeneID" id="87888975"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000237">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008630">
        <property type="entry name" value="Glyco_trans_34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306:SF8">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 34 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05637">
        <property type="entry name" value="Glyco_transf_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3309814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="311" mass="36043" checksum="FF7AFEBE6083DB05" modified="2024-07-24" version="1">MLSRTAVLKALLTATPILIILHQDNIHCYGKPDCFPAKRHPSLFDVKHNKDFCLKHGATLRDPPPRLAMVTAQLGIPEKHYQRALRTHALHNAVHGTGIHILCTKIVDDLWNKPAFILDLLLREMEKPESDRLEWLFWVDRDTIILDTCRSPLSFLPPREKEFNNHTEQPKDGKPEIHMLATKDWNGLNNGVFLVQVNRWSVDLFFAILAFRYYRPDVELTWSEQSAMGFLLEEPQFRDNVAWVPQWWLNPYPPGDFLVHFAGVGGLEQARQAMKPWLDVAETAVDGWAAEPRERDLNKEIRDFWEGREST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M676</accession>
    <name>A0AAJ0M676_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_518320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726150.1">
        <property type="nucleotide sequence ID" value="XM_062868354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M676"/>
    <dbReference type="GeneID" id="87887183"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="50"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3310370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="167" mass="17803" checksum="7C5CC8C766CC1ED2" modified="2024-07-24" version="1">MSRHAGPIKELVNLYDTTTAAAAAEAEILEAAGTDTTAKTPAKVRSAGRDTDNSPYPSVDIFAAPSHWTLLVAVPGVKQEDVSLCWDDRSSTLAIRGNVATPGGYEEEEMGRMVLGERKVGAFERAIRLPPGEEEEGGGMLVDGERMTSKLEDGVMIVTMPKTKPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M695</accession>
    <name>A0AAJ0M695_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mannosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0T15DRAFT_519005</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the eighth mannose residue in an alpha-1,6 linkage onto Man(7)GlcNAc(2)-PP-dolichol to produce Man(8)GlcNAc(2)-PP-dolichol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29535"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="Rhea" id="RHEA-COMP:19518"/>
            <dbReference type="Rhea" id="RHEA-COMP:19519"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:132517"/>
            <dbReference type="ChEBI" id="CHEBI:132519"/>
            <dbReference type="EC" id="2.4.1.260"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:29536"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyltransferase 22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726418.1">
        <property type="nucleotide sequence ID" value="XM_062868410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M695"/>
    <dbReference type="GeneID" id="87887239"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052917">
        <property type="term" value="F:dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF1">
        <property type="entry name" value="DOL-P-MAN:MAN(7)GLCNAC(2)-PP-DOL ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 12 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="204"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="379"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="498"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="583"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3310638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="664" mass="72319" checksum="F88A575B8BE77D66" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">B0T15DRAFT_564700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726718.1">
        <property type="nucleotide sequence ID" value="XM_062870649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M6J4"/>
    <dbReference type="GeneID" id="87889478"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="626"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="683"/>
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        </location>
    </feature>
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        <location>
            <begin position="156"/>
            <end position="169"/>
        </location>
    </feature>
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        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="546"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3310938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="835" mass="90198" checksum="DE4BCF46E8AD2CB1" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ0M6M6_9PEZI</name>
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        <recommendedName>
            <fullName evidence="5">SURF1-like protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="6" type="ORF">B0T15DRAFT_507392</name>
    </gene>
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        <lineage>
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    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
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        <text evidence="5">Probably involved in the biogenesis of the COX complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Mitochondrion inner membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SURF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAK3310757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0005743">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR002994">
        <property type="entry name" value="Surf1/Shy1"/>
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    <dbReference type="InterPro" id="IPR045214">
        <property type="entry name" value="Surf1/Surf4"/>
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    <dbReference type="PANTHER" id="PTHR23427">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427:SF2">
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU363076"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M6W8</accession>
    <name>A0AAJ0M6W8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_548168</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726822.1">
        <property type="nucleotide sequence ID" value="XM_062870190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M6W8"/>
    <dbReference type="GeneID" id="87889019"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057373">
        <property type="entry name" value="ZNFX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF341">
        <property type="entry name" value="NFX1-TYPE ZINC FINGER-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="104"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="3">
        <location>
            <begin position="301"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="3">
        <location>
            <begin position="621"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="4">
        <location>
            <begin position="696"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1102"/>
            <end position="1188"/>
        </location>
    </feature>
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        <location>
            <begin position="1109"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1140"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1167"/>
            <end position="1178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF25396"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3311042.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1188" mass="133348" checksum="5854BCD3668E2B59" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M782</accession>
    <name>A0AAJ0M782_9PEZI</name>
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        <recommendedName>
            <fullName evidence="13">40S ribosomal protein S9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_490075</name>
    </gene>
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        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_062866651.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="40S ribosomal protein S9"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_uS4_CS"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_uS4_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_uS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003139">
        <property type="entry name" value="PRK04051.1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="uS4_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF5">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS4 N-terminal" evidence="10">
        <location>
            <begin position="4"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-binding S4" evidence="9">
        <location>
            <begin position="105"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3311465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="190" mass="21933" checksum="D53507863A375FE3" modified="2024-07-24" version="1">MAPRSYSKTAKVPRRPFEAARLDSELKLVGEYGLRNKREVWRVLLTLSKIRRAARELLTLDEKDPKRLFEGNALIRRLVRVGVLDESRMKLDYVLALKAEDFLERRLQTLVYKLGLAKSIHHARVLIRQRHIRVGKQIVNVPSFIVRLDSQKHIDFALTSPFGGGRPGRVRRKKAKAAEKGEEGEDEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GKZ2</accession>
    <name>A0AAJ0GKZ2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_325389</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717635.1">
        <property type="nucleotide sequence ID" value="XM_062864103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GKZ2"/>
    <dbReference type="GeneID" id="87882932"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF6">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3301855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="629" mass="72306" checksum="C1B2BA14CC1EA12C" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GLB7</accession>
    <name>A0AAJ0GLB7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial import inner membrane translocase subunit TIM14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Mitochondrial import inner membrane translocase subunit tim14</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 13">Presequence translocated-associated motor subunit PAM18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0T15DRAFT_496522</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TIM14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717826.1">
        <property type="nucleotide sequence ID" value="XM_062867181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GLB7"/>
    <dbReference type="GeneID" id="87886010"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000001">
        <property type="entry name" value="Import inner membrane translocase subunit tim14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12763">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12763:SF28">
        <property type="entry name" value="GEO10507P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="J" evidence="14">
        <location>
            <begin position="52"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00067223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00075483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3302046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="106" mass="11410" checksum="67DED816794CB749" modified="2024-07-24" version="1">MSSAVAIGAGVAVAAFLGRAGLVAWRRSRGGVGALGKAFYKGGFEPRMNRREAALILSLNESSLSKEKVRKAHRTLMLLNHPDRGGSPYLATKVNEAKEFLEKNVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GLN9</accession>
    <name>A0AAJ0GLN9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_403256</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718023.1">
        <property type="nucleotide sequence ID" value="XM_062865197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GLN9"/>
    <dbReference type="GeneID" id="87884026"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032801">
        <property type="entry name" value="PXL2A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF16">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13911">
        <property type="entry name" value="AhpC-TSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
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    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
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    <feature type="region of interest" description="Disordered" evidence="7">
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    <feature type="compositionally biased region" description="Polar residues" evidence="7">
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="829" mass="91311" checksum="60F6B5AD47DF8F68" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ0GM56_9PEZI</name>
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    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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            <authorList>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
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                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
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        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
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                <person name="Brannstrom I.O."/>
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
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                <person name="Martin F."/>
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                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
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                <person name="Powell A.J."/>
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                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="6">CBS 333.67</strain>
        </source>
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        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
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                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
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                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
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                <person name="Cros-Aarteil S."/>
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
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                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
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                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GeneID" id="87882724"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <end position="55"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3302519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="671" mass="73255" checksum="B411E69344AB0501" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GN23</accession>
    <name>A0AAJ0GN23_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_314010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718525.1">
        <property type="nucleotide sequence ID" value="XM_062863965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GN23"/>
    <dbReference type="GeneID" id="87882794"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF63">
        <property type="entry name" value="PHOSPHOLIPASE_CARBOXYLESTERASE_THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="3">
        <location>
            <begin position="12"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="173"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="186"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3302745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="312" mass="33982" checksum="D96497973F4189B5" modified="2024-07-24" version="1">MGEDQNRPSSATFIVEPSTRHTHSFILLHGLGSNGEKFGRELIESGVCSDGRTLPEIFPGARFIFPTSKRRRSSAFGRAMLTQWFDIASLDDPSHRSHKQVKGLQESSREILDLVDQESAKVPRENIILGGISQGCAMGLVCLLAMESPVGRFVGMSGWLPFRHEIDPIMGLDEDESESNEHGTDQDDDDIFGCADTDDPSATPSKPSGDEQKPVVKVLARVRDLLSLDSTESPCTDKSALTTPIFLGHGEADEKIRHSLGVGAHRTLTSLGFQASLRSYKGLGHWYKIPDEIDDIVAFIQHGASLPAAGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GN47</accession>
    <name>A0AAJ0GN47_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_538880</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. Lipase family. Class 3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718807.1">
        <property type="nucleotide sequence ID" value="XM_062869704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GN47"/>
    <dbReference type="GeneID" id="87888533"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051218">
        <property type="entry name" value="Sec_MonoDiacylglyc_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856:SF11">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="5">
        <location>
            <begin position="101"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="344"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="349"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00043996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00047591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3303027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="370" mass="41582" checksum="9885ADAF7D93F04F" modified="2024-07-24" version="1">MVSILKDIQHLVRYAHWAYMDDDGAEFRSAAQDLEGDVNYRKLKIVTPFFKDFKALTPNTHVHLGVRNGDTLVLAFRGTDFPFTVENLVNPKSWWGFWGNVVTDVAFRMVQIHWLPGDNPAILAHDGFLAAFNNLLKDDRLGSCILQLMGDLPPSKIEVCGHSLGGALATLCALWCRTRWHYANIKCVTLGSPRVGNEAFCQRFHSSAILCYRLEMDGDPIPTVPDRFTQAVPGKLPANDPSWTEGDRTYGHVGIPIILHGAGGRVIYNSVDYDVERPDIEAEKDAPPLPWQFRLPYEFGGFLPYWILRGLKMLPAIWQYHDPTGYETVVQRILERTGETSHAACNGSVPLSQRTPTLTSRHRSPNGWQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GN98</accession>
    <name>A0AAJ0GN98_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_437868</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3302865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718645.1">
        <property type="nucleotide sequence ID" value="XM_062865859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GN98"/>
    <dbReference type="GeneID" id="87884688"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF7">
        <property type="entry name" value="CIPA-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="4">
        <location>
            <begin position="14"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3302865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="321" mass="35112" checksum="BD42EFBA4C428ECF" modified="2024-07-24" version="1">MAPSKLFEKIAIVGATGHIGQIFVSELLKTGKHTITALTRAESKGTPPESVKRVQVNYNDQETLVAALRGQDFLIITLAVRAPPDTHRKLVRAAAATGVPYVMPSFYGSDIRNPKLASEAFGAVIKAQLDEMESLGLSYVSLACGTWYEWSLALGDAWFGFQIKDRKVTFFDDGKTIVNVSTWEMCGRAVAALLSLPESGASPSLSDWKNEPVYIRSFQVSQRDILDSLHRVLNTTDEDWVISYEPAGKRAQDGLEEFSKGIITGMAKNMYAKLFIRSKAGELDYAEGLANEVLGLPEESLDGATKRAVEMVESGWNPLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GNB1</accession>
    <name>A0AAJ0GNB1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_262937</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718864.1">
        <property type="nucleotide sequence ID" value="XM_062863363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GNB1"/>
    <dbReference type="GeneID" id="87882192"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3303084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="122" mass="13814" checksum="48BE14575D9B9587" modified="2024-07-24" version="1">MEKLQQIPVPMSVAKLVHSRQPARVAVFVQRKSSLYTSSPDQIVKIACTALDIPVDDSRPTLLVVEKWDRLDVLVFDIFHVEYDFSTAHLETDLPVILVDYGKRYSVIKDARAGFRKEATVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GNJ5</accession>
    <name>A0AAJ0GNJ5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein uS7m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_269048</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719048.1">
        <property type="nucleotide sequence ID" value="XM_062863440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GNJ5"/>
    <dbReference type="GeneID" id="87882269"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14868">
        <property type="entry name" value="uS7_Mitochondria_Fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.455.10:FF:000006">
        <property type="entry name" value="37S ribosomal protein S7, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="entry name" value="Ribosomal protein S7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_uS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_uS7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_uS7_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047988">
        <property type="entry name" value="Ribosomal_uS7m_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="Ribosomal protein S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 10" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS7" evidence="9">
        <location>
            <begin position="107"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="24"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3303268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="283" mass="31082" checksum="A0B0A45103583347" modified="2024-07-24" version="1">MPPRLNIWSAYRALSVRTRAFAQATQPGPAAQTRGLADNTTSRFPPSASGALPPSMLPESEPLAYTSKENEAALNQLRMIEYGLSPLDPSVEGHKYGLPELPLPSQKHAKHRYDAVITQVTKLLMRDGKLAKAQRDMAMILNYLRTSPPPKLDPAKPLLPGAPPAHHLPLDPVLYLGLAIDSVAPLIRMRGFKGLAGGGKSLEVPMPLRARQRRRTAFQWILDVVNKRKSKGSGRNMFPHRVAEEIVAVVEGRSTVWDKRLQVHKAGTSNRANLTHSGIKGMI</sequence>
</entry>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="4">CBS 333.67</strain>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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            <fullName evidence="6">Ankyrin repeat-containing domain protein</fullName>
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        <lineage>
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    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
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                <person name="Natvig D.O."/>
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                <person name="Ament-Velasquez S.L."/>
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                <person name="Powell A.J."/>
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                <person name="Hiltunen Thoren M."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
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                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
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                <person name="Kuo A."/>
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                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
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                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
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                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
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                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
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                <person name="Cros-Aarteil S."/>
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
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                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
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        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
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                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
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                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Cros-Aarteil S."/>
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                <person name="Kuo A."/>
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                <person name="Ng V."/>
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                <person name="Ohm R.A."/>
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                <person name="Barry K."/>
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                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
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                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Bonometti L."/>
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                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
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                <person name="Chen C."/>
                <person name="Yanf M."/>
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                <person name="Martin F."/>
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                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
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                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
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        <text evidence="2">Component of the NuA4 histone acetyltransferase complex.</text>
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        </subcellularLocation>
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    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
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        <property type="entry name" value="Heterochromatin_chromo-domain"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
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        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="118"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="4">
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            <end position="1403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3304303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1429" mass="160012" checksum="0D7AB4E93E28902B" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQM9</accession>
    <name>A0AAJ0GQM9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HECT-type E3 ubiquitin transferase</fullName>
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        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the UPL family. TOM1/PTR1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="4"/>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720144.1">
        <property type="nucleotide sequence ID" value="XM_062867477.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87886306"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000004">
        <property type="entry name" value="E3 ubiquitin-protein ligase HUWE1, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000003">
        <property type="entry name" value="E3 ubiquitin-protein ligase UPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010309">
        <property type="entry name" value="E3_Ub_ligase_DUF908"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010314">
        <property type="entry name" value="E3_Ub_ligase_DUF913"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025527">
        <property type="entry name" value="HUWE1/Rev1_UBM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF67">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HUWE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06012">
        <property type="entry name" value="DUF908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06025">
        <property type="entry name" value="DUF913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14377">
        <property type="entry name" value="UBM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="7 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="13">
        <location>
            <begin position="3723"/>
            <end position="4059"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="292"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="740"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="928"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1179"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1539"/>
            <end position="1584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1603"/>
            <end position="1659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1997"/>
            <end position="2042"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2071"/>
            <end position="2117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2367"/>
            <end position="2543"/>
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    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2580"/>
            <end position="2627"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2850"/>
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    <feature type="region of interest" description="Disordered" evidence="12">
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            <begin position="3036"/>
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    <feature type="region of interest" description="Disordered" evidence="12">
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            <begin position="3216"/>
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    <feature type="region of interest" description="Disordered" evidence="12">
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    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="292"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="317"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="330"/>
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        </location>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="12">
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    <feature type="compositionally biased region" description="Polar residues" evidence="12">
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            <end position="1656"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
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            <end position="2453"/>
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            <end position="2509"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
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    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
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    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
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            <end position="2912"/>
        </location>
    </feature>
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        </location>
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        <location>
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        <location>
            <position position="4026"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    <evidence type="ECO:0000256" key="3">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        <source>
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    <evidence type="ECO:0000256" key="6">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3304364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="4059" mass="452195" checksum="28634CC4CCC326FF" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GR50</accession>
    <name>A0AAJ0GR50_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="9">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_248635</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Lipid-anchor</topology>
            <topology evidence="1 9">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="9"/>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720398.1">
        <property type="nucleotide sequence ID" value="XM_062863141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GR50"/>
    <dbReference type="GeneID" id="87881970"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000032">
        <property type="entry name" value="1,3-beta-glucanosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF4">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 9" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8 9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042318071" description="1,3-beta-glucanosyltransferase" evidence="9">
        <location>
            <begin position="18"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="422"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="433"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="452"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3304618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="491" mass="52647" checksum="4E5BB7D517711F45" modified="2024-07-24" version="1">MLIHSALLALGATFAVALQPLEVQGEYFINPKTGNRFQIVGVAYQPGGAAGYNEESGRDPLSNADICMRDAALLQILGVNTIRVYNVNPNVNHDECASIFNAAGMYMILDVNSPLVGESLTSYHPWESYYAAYLNRTFAVVEAFKNYPNTLAFFSGNEVLNNEETGADVPPYMRAVTRDIKNYVKKHSSRPIPVGYSAADVRDILFDTYNYFQCSLEGDDGDMSMGDIFALNSYSWCGDSSFKKAKYDQLVEGFKGNSVPIFFSEFGCNTPYPRVFTEVGTIYGPDMTGVFSGGVVYEYTQEPNNYGLVNMTEDGSATLMGDFLSLQSQYAKLNFTEIQAQKPASTSTPKPPVCDAKLITTKGFNSNFTLPKLPPGAQEIIDKGVKPTPSGKLVEIKDWNVKFTVKNPDGSVISNLHVVPLKDDTINHPGSNTDATTAEASTTGSGTGTGTGTSSSAASSTPSRDAAPRAGAVVLPAVAMGALAAVAGFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GR96</accession>
    <name>A0AAJ0GR96_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WLM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_558496</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720397.1">
        <property type="nucleotide sequence ID" value="XM_062870472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GR96"/>
    <dbReference type="GeneID" id="87889301"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013536">
        <property type="entry name" value="WLM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47795:SF1">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47795">
        <property type="entry name" value="UBIQUITIN AND WLM DOMAIN-CONTAINING METALLOPROTEASE SPCC1442.07C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08325">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51397">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WLM" evidence="2">
        <location>
            <begin position="146"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3304617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="371" mass="41680" checksum="F248912A422496B7" modified="2024-07-24" version="1">MLDMAEPSPNDTRIDSLNPSDDDESSPVEITLKFPPEKHSQKWVFSSSDTFEHLILSLSLEFPSYDWSKAKALLEKRQPGLKSLYTPSDDAHIPLSTLHDTTLRLLAPQTSALSSLQHQRDAATSWQAKRALARARYARLPAAQRATADDLNYTFHTLRPLPHLPNSARSMAFLERLKADPGIRATMRKHRFSVGLLTEMDPLSHTAASHEGVTRILGLNRNKGEVIELRLRTDAYDGWRDYRVIRKTLCHELAHNVHSEHDAKFWALCKEIEREVERADWKHGGRTVGEEEYAPEREGGQDEGEGEEEGMVMDHGGWEGGTYVLGGGANTEGLSEREIRARAAEARWSNLERATRQSGDGKGESAQEKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GR99</accession>
    <name>A0AAJ0GR99_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_250977</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
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        <location>
            <begin position="16"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3304702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="85" mass="8111" checksum="719482339269461E" modified="2024-07-24" version="1">MRPVLVLALAGLATAQTTRTITEGVPTTSPTTTTTVTPSSTSPSPATTTVAGGTATETAIPTGAAIVHGPVAGLVVVGALCAALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ0GRK2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_363760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720591.1">
        <property type="nucleotide sequence ID" value="XM_062864162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GRK2"/>
    <dbReference type="GeneID" id="87882991"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3304811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="82" mass="9288" checksum="24320177B904103A" modified="2024-07-24" version="1" fragment="single">HRPNKKIKSRGRLHGPSNFPPEFWDNLSKVPLTRRALRELDRRNSTQPALGPAVPAVCTAYLARFARHGGPDLRHLRAVCLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ0GS66_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_512988</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720685.1">
        <property type="nucleotide sequence ID" value="XM_062868016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GS66"/>
    <dbReference type="GeneID" id="87886845"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3304905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="112" mass="13025" checksum="DFF718257AC740AF" modified="2024-07-24" version="1">MTAPRHRFIPFAFQDELAQQLAAQTLVLGGGSLYIYDLPQSYEARDLNEKQMPHSLNMSTKEMDLEDGCFATTFERKYYHRGGVSIEEFTTRSKPHRLPRSLMYLYSERNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GSP7</accession>
    <name>A0AAJ0GSP7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">U4/U6 snRNA-associated-splicing factor PRP24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0T15DRAFT_397009</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a recycling factor of the spliceosome, a machinery that forms on each precursor-messenger RNA (pre-mRNA) and catalyzes the removal of introns. Chaperones the re-annealing of U4 and U6 snRNAs (small nuclear RNAs) released from previous rounds of splicing, an initial step in reforming the U4/U6-U5 tri-snRNP (small nuclear ribonucleoprotein) that can reassemble into another spliceosome complex; this step involves binding U6 and facilitating the unwinding of the U6 internal stem loop, followed by base-pairing of U6 to U4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720955.1">
        <property type="nucleotide sequence ID" value="XM_062864877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GSP7"/>
    <dbReference type="GeneID" id="87883706"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12296">
        <property type="entry name" value="RRM1_Prp24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12297">
        <property type="entry name" value="RRM2_Prp24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000365">
        <property type="entry name" value="U4/U6 snRNA-associated-splicing factor PRP24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034397">
        <property type="entry name" value="Prp24_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034398">
        <property type="entry name" value="Prp24_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031766">
        <property type="entry name" value="RRM_occluded"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10352">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16842">
        <property type="entry name" value="RRM_occluded"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="608"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="682"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="774"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="550"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="862"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="987"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="592"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="865"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1061"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1094"/>
            <end position="1105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00093627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3305175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1105" mass="122784" checksum="99FA851C1FEC59A1" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GSW0</accession>
    <name>A0AAJ0GSW0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Insertion element IS150 protein InsJ-like helix-turn-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_532602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721308.1">
        <property type="nucleotide sequence ID" value="XM_062869320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GSW0"/>
    <dbReference type="GeneID" id="87888149"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055247">
        <property type="entry name" value="InsJ-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13518">
        <property type="entry name" value="HTH_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Insertion element IS150 protein InsJ-like helix-turn-helix" evidence="1">
        <location>
            <begin position="26"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3305528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="87" mass="9382" checksum="E43CA41A62FA0D99" modified="2024-07-24" version="1">MVNLAEIGAKLTAGRQPGQELSPTARAAIIGAVAAGASQSAIARAFRIDRTAIYHILQQFESSTTIESKPQTGRPEILTCREKRYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GSW4</accession>
    <name>A0AAJ0GSW4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Oxidation resistance protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_555727</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May be involved in protection from oxidative damage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OXR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721282.1">
        <property type="nucleotide sequence ID" value="XM_062870401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GSW4"/>
    <dbReference type="GeneID" id="87889230"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354:SF62">
        <property type="entry name" value="MUSTARD, ISOFORM V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354">
        <property type="entry name" value="NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="7">
        <location>
            <begin position="139"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="65"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3305502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="344" mass="37183" checksum="770792F05F6375CD" modified="2024-07-24" version="1">MTFYSSHLNQPLRSHHSPDFDSSPASSPGAITPPGGPVSPSSSTFLSSSVSSLWGGLVRRFSGEPSASARIPSGLPHARTFEPDGDGKDKPSGYGNGLDNVYIPTHLLHARRTASPMPPPPLEPLQLVGFSEETRHDARLLTKPIAEEIRIMVPARLGIVDEWRLVYSLEQDGASLATLFEKCAKYQGKRVGFVLCVKDCEGGLFGAYLSDPPHPAPKYFGTGECFLWRASVLSPLPPPPSAIDNHPTTNTRTATITAEQPSRSTTPHSIRFKAFPYSGINEYYMLCEPHFLSLGAGDGKYGLWLDDSLERGVSSTSQTFGNEPLSDEGEKFGVLGVEVWVIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GSZ5</accession>
    <name>A0AAJ0GSZ5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C-1-tetrahydrofolate synthase, cytoplasmic</fullName>
            <ecNumber evidence="8">1.5.1.5</ecNumber>
            <ecNumber evidence="7">3.5.4.9</ecNumber>
            <ecNumber evidence="6">6.3.4.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">B0T15DRAFT_484997</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.5" evidence="8"/>
    <dbReference type="EC" id="3.5.4.9" evidence="7"/>
    <dbReference type="EC" id="6.3.4.3" evidence="6"/>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721145.1">
        <property type="nucleotide sequence ID" value="XM_062866264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GSZ5"/>
    <dbReference type="GeneID" id="87885093"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004329">
        <property type="term" value="F:formate-tetrahydrofolate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00477">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000006">
        <property type="entry name" value="Bifunctional protein FolD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1510.10:FF:000002">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000245">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001123">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000005">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.410.10:FF:000001">
        <property type="entry name" value="Putative formate--tetrahydrofolate ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1510.10">
        <property type="entry name" value="Domain 2, N(10)-formyltetrahydrofolate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.410.10">
        <property type="entry name" value="Formyltetrahydrofolate synthetase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01543">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000559">
        <property type="entry name" value="Formate_THF_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020628">
        <property type="entry name" value="Formate_THF_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020867">
        <property type="entry name" value="THF_DH/CycHdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099:SF5">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01268">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00721">
        <property type="entry name" value="FTHFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00722">
        <property type="entry name" value="FTHFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00766">
        <property type="entry name" value="THF_DHG_CYH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00767">
        <property type="entry name" value="THF_DHG_CYH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 22" id="KW-0436">Ligase</keyword>
    <keyword evidence="19" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="17" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic" evidence="20">
        <location>
            <begin position="6"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding" evidence="21">
        <location>
            <begin position="143"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00017592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAK3305365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="939" mass="100103" checksum="C832C3808B837EC8" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GTN4</accession>
    <name>A0AAJ0GTN4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_208094</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721520.1">
        <property type="nucleotide sequence ID" value="XM_062862639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GTN4"/>
    <dbReference type="GeneID" id="87881468"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042566348" description="Secreted protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3305740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="158" mass="16895" checksum="A7EA808450BDB7A3" modified="2024-07-24" version="1">MRTWMLCLRWLAFPRCPGKISLANISVVCARPCQTARLELRNGHRNPSFHTPHAMHLRNASAGQVCRPPGGAILGVTRSSAGNGLSLPPLTFCLAAATWLPTHPLWHTAFTAFIPLEACQARENRDASAPLLATGSSHTRGSGRYPSAGHGPSPISSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GTS2</accession>
    <name>A0AAJ0GTS2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_210345</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721580.1">
        <property type="nucleotide sequence ID" value="XM_062862667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GTS2"/>
    <dbReference type="GeneID" id="87881496"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056687">
        <property type="entry name" value="DUF7785"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057199">
        <property type="entry name" value="DUF7877"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48139:SF1">
        <property type="entry name" value="FIBROUS SHEATH CABYR-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48139">
        <property type="entry name" value="SI:DKEY-56M19.5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25009">
        <property type="entry name" value="DUF7785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25289">
        <property type="entry name" value="DUF7877"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7877" evidence="4">
        <location>
            <begin position="62"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7785" evidence="3">
        <location>
            <begin position="451"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="81"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="680"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="889"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="440"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="188"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="266"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="680"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="706"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="747"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="774"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="801"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="925"/>
            <end position="937"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3305800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="946" mass="101782" checksum="688FE702AD402080" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GTU3</accession>
    <name>A0AAJ0GTU3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_215194</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721747.1">
        <property type="nucleotide sequence ID" value="XM_062862725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GTU3"/>
    <dbReference type="GeneID" id="87881554"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF75">
        <property type="entry name" value="CENTROMERE-ASSOCIATED PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="5">
        <location>
            <begin position="39"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="462"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="488"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="130"/>
            <end position="137"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3305967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="610" mass="66613" checksum="04E793A87B6F5CCA" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GTY2</accession>
    <name>A0AAJ0GTY2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_503077</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3306083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721863.1">
        <property type="nucleotide sequence ID" value="XM_062867459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GTY2"/>
    <dbReference type="GeneID" id="87886288"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF736">
        <property type="entry name" value="RETINOL DEHYDROGENASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="5">
        <location>
            <begin position="123"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3306083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="398" mass="43364" checksum="9978C29580861754" modified="2024-07-24" version="1">MATHRENNGFHIDTVAHIIRKTLLNEYVTLPLAAAATWLSRPSFSSSSPAATHLGRILDVVLASNSAFGINLDLDLALPQLARLALWLGGTGLLLSANTLLNKWASNNWTPCLPGEWAHWEREIVVVTGGSSGIGEHVVKALLARNPRTRIVIIDFAPLSWTPPPTTKNLHYYQADLSKPEQIRAVCARVRDEVGDPTVLINNAGLVRGRTVLEGTYGDVEATVRTNLTAPFLLLKEFLPAMVRANHGHVVSLCSSSALMPPPDLVDYAASKAGVQALHEGLGMELRYRHAAPRVRLTNCVFNFIKTPLVRGTPTQPQFLAPMLHVETVSEAIVDALYSGYGGVLYLPGLMRYVAMLRAAPEWLFRVLIKNSTAQLGVDLRGRQAIDATGSLQQAETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GUQ3</accession>
    <name>A0AAJ0GUQ3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Translation machinery associated TMA7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_492069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722312.1">
        <property type="nucleotide sequence ID" value="XM_062866834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GUQ3"/>
    <dbReference type="GeneID" id="87885663"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015157">
        <property type="entry name" value="TMA7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28632">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09072">
        <property type="entry name" value="TMA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3306532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="69" mass="7351" checksum="2A8F23C95C93A9A1" modified="2024-07-24" version="1">MGGISRDGGKAKPLKAPKKGPKELDEEDKAFLEKKRAYEKEKKELAAKAGGKKGPLNTGAQGIKKSGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GVG2</accession>
    <name>A0AAJ0GVG2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0T15DRAFT_501465</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722643.1">
        <property type="nucleotide sequence ID" value="XM_062867398.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87886227"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071561">
        <property type="term" value="C:nucleus-vacuole junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13980">
        <property type="entry name" value="STKc_Vps15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000497">
        <property type="entry name" value="Phosphoinositide 3-kinase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001688">
        <property type="entry name" value="Phosphoinositide 3-kinase regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055231">
        <property type="entry name" value="2AA_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045162">
        <property type="entry name" value="Vps15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17583">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17583:SF0">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22956">
        <property type="entry name" value="VPS15-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="25"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="1125"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="906"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1455"/>
            <end position="1519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="912"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="959"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1001"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1465"/>
            <end position="1478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1491"/>
            <end position="1501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1509"/>
            <end position="1519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3306863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1562" mass="174034" checksum="20C84DC8459EEE21" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GVN1</accession>
    <name>A0AAJ0GVN1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fumarylacetoacetase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_157804</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722707.1">
        <property type="nucleotide sequence ID" value="XM_062862077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GVN1"/>
    <dbReference type="GeneID" id="87880906"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018773">
        <property type="term" value="F:acetylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000002">
        <property type="entry name" value="2-hydroxyhepta-2,4-diene-1,7-dioate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF7">
        <property type="entry name" value="ACYLPYRUVASE FAHD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="77"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3306927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="290" mass="31146" checksum="1FC6F27382C68FDC" modified="2024-07-24" version="1">MSFDRLVRFVPKGHDSKILIGEPVDGSVDVGAAVRKGEDVQVKVYSGTSVLDAGSPTSETATIGRVLSPLAREEVGTIRCIGLNYKKHAEEAKMTIPEIPTVFLKPETCLADPWPAPTIIPKHTIASDSADYESELAVIIGKEAKNVSEADALDYVLGYTASNDISSRAAQFAQTQWCYSKGFDGACPLGPVLVSKRLVPDVGKLRLRGLKNGKVVQDSGLTDLIFSVEKIVSFLSQGTTLPRGTVIITGTPAGVGFAHKPQELLHDGDEFVVEIQPHIGSLYNVMKNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GVV5</accession>
    <name>A0AAJ0GVV5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ras-like GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_492613</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722897.1">
        <property type="nucleotide sequence ID" value="XM_062866870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GVV5"/>
    <dbReference type="GeneID" id="87885699"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001584">
        <property type="entry name" value="Ras-like GTP-binding protein RYL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24073">
        <property type="entry name" value="DRAB5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="152"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="310"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3307117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="336" mass="36516" checksum="792106EBF2A7C002" modified="2024-07-24" version="1">MSSSLEAKIVVLGAQGVGKTSLVMRYCKGAFNPSQITSTVGASFLTKRVVDTDTDTIVRLQIWDTAGQERFRSISRLYYRGANACILCYSITDAQSFAEMGIWLTELRRNLPPDIVLHVVGTKADIVARDPSQREVPFERCIAYVAENLNPGMGSTPPPTAGGFLSPSSSSADHHHQHNSTPQQSSQHWGLLQGSGDGAELRSPSSKRSSGFWGQEVGWDACHEISAESGEGVEEVFRVVTRKLVEQNRKMQAALLAATGSTPGDGFTPGFGPNEADGGYFDAVNGRGSFRVGRDRRSWLFSPGFSPVIGGTVPEEDREGWEQDGDRRGRPRRTCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GW55</accession>
    <name>A0AAJ0GW55_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_165054</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722885.1">
        <property type="nucleotide sequence ID" value="XM_062862150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GW55"/>
    <dbReference type="GeneID" id="87880979"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF91">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="40"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3307105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="487" mass="53431" checksum="41001C86AA885384" modified="2024-07-24" version="1">MSESDKAGKPTEGYEAESAQLEEWDAVAEAKLVRRMDLFLLPVVMLLYLLSFLDRVNIGNARLYKMEADLGLVGNQYQVAVSILFVTYILSELPSNLVLKKLRPSRWIAFITTAWGIIATLTGIAQNYGGLLACRLLLGAVEGGLFPGMAIYLTFFYTKRELALRIGYLFVSAALAGACGGLLAFAIGHMQGVAGQNGWRWIMIIEGLPTVCLGIASWWLLPDEPETAYFLDGPQRAMAAARLRRQTGYTANAAEFHWQDVRAALGDWKVWAFALAQFGSDTMLYGYSTFLPTIIRGINPDASAALVQVLTIPCYALGAVTYLVVARISDRTQKRGMYAVLLGLVSIVGYAMLISDVGSGAHYAGCFLVAMGLYVCVGLPLAWLPTNCPRYGKRTTATGLQLTIGNCSGIMASYLYPLEQGPRYIRGHAVTMAMVAWACLVYVVLWFSYSRANAKRRRGDEDHKTEGISDDEIAELGDESPRFVYTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GWD2</accession>
    <name>A0AAJ0GWD2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_529854</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723082.1">
        <property type="nucleotide sequence ID" value="XM_062869134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GWD2"/>
    <dbReference type="GeneID" id="87887963"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000111">
        <property type="term" value="C:nucleotide-excision repair factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071942">
        <property type="term" value="C:XPC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2460:FF:000001">
        <property type="entry name" value="DNA repair protein Rad4 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.20.110">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2460">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.260.10">
        <property type="entry name" value="Transglutaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018327">
        <property type="entry name" value="BHD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004583">
        <property type="entry name" value="DNA_repair_Rad4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018325">
        <property type="entry name" value="Rad4/PNGase_transGLS-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018326">
        <property type="entry name" value="Rad4_beta-hairpin_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018328">
        <property type="entry name" value="Rad4_beta-hairpin_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042488">
        <property type="entry name" value="Rad4_BHD3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036985">
        <property type="entry name" value="Transglutaminase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135:SF2">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135">
        <property type="entry name" value="DNA REPAIR PROTEIN XP-C / RAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10403">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10404">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10405">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03835">
        <property type="entry name" value="Rad4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01030">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01031">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01032">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="8">
        <location>
            <begin position="597"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="9">
        <location>
            <begin position="658"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="10">
        <location>
            <begin position="728"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="209"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="368"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="868"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="795"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="212"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="906"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="940"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="966"/>
            <end position="985"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3307302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="985" mass="110702" checksum="1D5FB44CA39D694C" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GWP0</accession>
    <name>A0AAJ0GWP0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_181815</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723323.1">
        <property type="nucleotide sequence ID" value="XM_062862321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GWP0"/>
    <dbReference type="GeneID" id="87881150"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17330">
        <property type="entry name" value="MFS_SLC46_TetA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
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        <property type="entry name" value="MFS_dom"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 333.67</strain>
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    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="3">Rrp15p-domain-containing protein</fullName>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRP15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724291.1">
        <property type="nucleotide sequence ID" value="XM_062861477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GYH6"/>
    <dbReference type="GeneID" id="87880306"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012459">
        <property type="entry name" value="Rrp15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13245">
        <property type="entry name" value="RRP15-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13245:SF14">
        <property type="entry name" value="RRP15-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07890">
        <property type="entry name" value="Rrp15p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="68"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3308511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="346" mass="36839" checksum="A1108741C9F51D65" modified="2024-07-24" version="1">MAGSSIRKRSFNDGPKGRTVRPTKKQRKIAAYHSSSDESDSDDEGARVPANLLDSEDEDLDDIEVDDGASSADSASDSNSDSASEARDPSSKRKPQSRPKEKESQAKQFIARDAPDSEDDASSAEENADDGGDDDDEDGMSDAASHSDASQTGGGKSSSSRPSTKSKRNDPAAFATSISKMLSSKLPASRRADPIVARSADAAEHARQAADSALEAKARKRLREQKRLAMEKGRVRNVLVASTTRTLNVATGEIEEVPEEGAETTEQILAAEKRLRKVAQRGVVKLFNAVRAAQVKAAEAERAARREGVVGVKRKEEKVAEMSRKGFLDLIASGGGGLKKGGLEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GYI6</accession>
    <name>A0AAJ0GYI6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_524596</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724296.1">
        <property type="nucleotide sequence ID" value="XM_062868781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GYI6"/>
    <dbReference type="GeneID" id="87887610"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40624">
        <property type="entry name" value="BIOSYNTHESIS MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12025)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40624:SF1">
        <property type="entry name" value="BIOSYNTHESIS MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12025)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="3"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3308516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="105" mass="11735" checksum="EC5CF72CABF2FBAF" modified="2024-07-24" version="1">MPFHILAIITPKADRIARVEEIAKEVATEVEKNEPGTLKYQWFRTGTAEAPTIVVWEVYADEAAFETHKTSPALARLIEIEKQEGNLAAPLEVQPLEQFAGFASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GYL1</accession>
    <name>A0AAJ0GYL1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">t-SNARE affecting a late Golgi compartment protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0T15DRAFT_111241</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724351.1">
        <property type="nucleotide sequence ID" value="XM_062861504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GYL1"/>
    <dbReference type="GeneID" id="87880333"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21444">
        <property type="entry name" value="SNARE_NTD_Tlg1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15851">
        <property type="entry name" value="SNARE_Syntaxin6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.90:FF:000012">
        <property type="entry name" value="SNARE domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000006">
        <property type="entry name" value="Syntaxin 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015260">
        <property type="entry name" value="Syntaxin-6/10/61_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048036">
        <property type="entry name" value="Tlg1p-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09177">
        <property type="entry name" value="STX6_10_61_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="13">
        <location>
            <begin position="167"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="106"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3308571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="259" mass="28553" checksum="6D7BD4626D7A1C19" modified="2024-07-24" version="1">MMSSTNEEDPFLQVQQDVLNQLQSARSLFTSYLRIRSLATSATSPELASARADLESSLNSLAEDLADLVESVRVVESNPSHYGLSAAEVTRRKRLVQEVGGEVDDMREELSKVASSTSAGGAAGRNQKGKGSSGTDLPEPSWFAIPDGEGGDADNDYAAEFEREQQVVMMREQDEHLDGVFQTVGNLRRQADDMGRELEEQVEMLEVVDQLADRVGGRLQTGMEKLKYVMRRTEDRWSSCCIGVLIVVLIILLILLLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GYM1</accession>
    <name>A0AAJ0GYM1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cholesterol oxidase</fullName>
            <ecNumber evidence="13">1.1.3.6</ecNumber>
            <ecNumber evidence="11">5.3.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Cholesterol isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B0T15DRAFT_111319</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="12">Steroid metabolism; cholesterol degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.6" evidence="13"/>
    <dbReference type="EC" id="5.3.3.1" evidence="11"/>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724356.1">
        <property type="nucleotide sequence ID" value="XM_062861508.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87880337"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016995">
        <property type="term" value="F:cholesterol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004769">
        <property type="term" value="F:steroid Delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052542">
        <property type="entry name" value="Cholesterol_Oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47470">
        <property type="entry name" value="CHOLESTEROL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47470:SF1">
        <property type="entry name" value="FAD-DEPENDENT OXIDOREDUCTASE 2 FAD BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8" id="KW-1207">Sterol metabolism</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="17">
        <location>
            <begin position="236"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="18">
        <location>
            <begin position="639"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="724"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="729"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAK3308576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1385" mass="152794" checksum="E4763EB82552F701" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GYS8</accession>
    <name>A0AAJ0GYS8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_491219</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724433.1">
        <property type="nucleotide sequence ID" value="XM_062866757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GYS8"/>
    <dbReference type="GeneID" id="87885586"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNH nuclease" evidence="2">
        <location>
            <begin position="151"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3308653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="319" mass="35694" checksum="474986D92E85D7E5" modified="2024-07-24" version="1">MDSDIDHFQRAVTADRETVLAFLRDIPPPTEPVHDYITDIDERCTLSSEIRQLHEDLGLPEPNAATLAFFMVAPTSQIREHLAILRNTPPEFMATHVIAFDLQAASTIYVPTNRSSPPESSTLLAPPTMMLGNQHEVSRKRAAEARDGHACLLSGMGDPEAAHIFPFSLSKKRFGQLHTLLQAFWGVEKAATWAKLYQDPAMTQSIANYLSLSRHLHHWFDDARLALKPLSQTSTTIKVQFHWLRVATLEPTIQIDASEETLADWAGLRETLQDRPSIRQQSEAKTKTEHREAPSPPELLTKERTLPSRIPDAGGSSND</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GZ88</accession>
    <name>A0AAJ0GZ88_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_108736</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724265.1">
        <property type="nucleotide sequence ID" value="XM_062861466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GZ88"/>
    <dbReference type="GeneID" id="87880295"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF11">
        <property type="entry name" value="ZINC FINGER PROTEIN YPR022C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="16"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3308485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="834" mass="93583" checksum="308E94653690C75C" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GZC2</accession>
    <name>A0AAJ0GZC2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Rhomboid-type serine protease</fullName>
            <ecNumber evidence="10">3.4.21.105</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0T15DRAFT_122272</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Serine protease involved in intramembrane proteolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.</text>
            <dbReference type="EC" id="3.4.21.105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the peptidase S54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.105" evidence="10"/>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724684.1">
        <property type="nucleotide sequence ID" value="XM_062861641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GZC2"/>
    <dbReference type="GeneID" id="87880470"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002610">
        <property type="entry name" value="Peptidase_S54_rhomboid-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936:SF69">
        <property type="entry name" value="RHOMBOID-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936">
        <property type="entry name" value="RHOMBOID-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="385"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="478"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="12">
        <location>
            <begin position="287"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3308904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="530" mass="58124" checksum="AA07E222C8857044" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GZZ2</accession>
    <name>A0AAJ0GZZ2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_135774</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3309262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725042.1">
        <property type="nucleotide sequence ID" value="XM_062861806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GZZ2"/>
    <dbReference type="GeneID" id="87880635"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="26"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="59"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="97"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="131"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="308"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="163"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="236"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="236"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3309262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="479" mass="52028" checksum="466603F71F9AD838" modified="2024-07-24" version="1">MNSGAPGLPSIFRVDSDVTHAEDEGGDAAHLRQAVIEGDEGLVRELLDHGADIEAADIVGRRALHQAVFRSGIKRNSITLAKLLLDCGANVEATTYDGEKPLWIAAKHGTVAMAKMLLERGADVESFNPKSGTTALFEAVNRGHVGLIELLLESGADIDARPLASHDASRRQDVGGRMSPESPDLVLTGAPRYSRHHRHYGGKELRPGAGHGHGDGSKAKTKYSLLDYLAGKSASKKDDVTEELEVRPAKRKRRTGSVYRRATTSHGGHEHAYPTPAPDLPPERFTDSGPGAALPRRGDVPTAQPHAGRELPLHQAVANGHAEVVKLLLQHGADPGIRDKNGRTAKQVAEQQDLEELATLFRTGPVLEGPAITSDKGKQREVPLVIPAPHPTPRNNPAKMAACQAFEATIIEFYTEEREQRYQQSATIYDLLYGKGPDEILSERRPESLQPRQADFTWYHLPANNVGVVTCTNKTWSMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H044</accession>
    <name>A0AAJ0H044_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_488046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725077.1">
        <property type="nucleotide sequence ID" value="XM_062866470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H044"/>
    <dbReference type="GeneID" id="87885299"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3309297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="124" mass="13858" checksum="81D6B8EE3674A2F5" modified="2024-07-24" version="1">MDLHAEYGDNPDDGYDYDLNMFRTEPCREQIEPLLAAFAKEVEEYGPPIRKGHRWGAKSIAARGSKKQKDGDAAAAVPTPPVVQWQVGDWRPGEEVMSLLESLGRQEWLDLEWDSNSSPIQSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H079</accession>
    <name>A0AAJ0H079_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_2567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725198.1">
        <property type="nucleotide sequence ID" value="XM_062863260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H079"/>
    <dbReference type="GeneID" id="87882089"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3309418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="133" mass="14044" checksum="C8DF511F5FE656FD" modified="2024-07-24" version="1">MRRLLAIPIRIPRATTSALRTTVNTLGVRCHPIYTPRSLGQQPRCSFFYSTQIQQGPDSSKTSDHLGPGYGPGPATGAGTGVFISAQMFGTEVKGNPTESEADVAADRCEADPLPPELHHKARSSGEAGLGPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H0G1</accession>
    <name>A0AAJ0H0G1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_6238</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725333.1">
        <property type="nucleotide sequence ID" value="XM_062871135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H0G1"/>
    <dbReference type="GeneID" id="87889964"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF49">
        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="2">
        <location>
            <begin position="82"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3309553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="377" mass="41866" checksum="816020DF5DCED849" modified="2024-07-24" version="1">MSAATTAPIIGTASLASPAKASTEVAALPPGFPARLADELAWTGRDFAKSSDHILTLDDVHHAEIKAALESFKSLDQDGDLVEPARFPLPTLGPKLKELSRDVHDGRGFCVIRGIDPATYSVEDLTLVYLGVQSYIAEQRGRQDKRGNMLVHIVADNSTKMAAEHHRHSTKAISFHNEESGDVVSWLTRSTAAAGGKCIIASAYTIYNVLAATRPDVIRTLARSDWPFAMPRFQCRPVIFYQGSRLIMNFGRAALMGSEAHPRPEHLPSLTARQVEALDAIETIAQATQLEIQTQAGDMHFINNLAILHRREGFVNGEAPSTKRHLVRMRLRSGDLGWSIPRELETEWEKAFNDNAPKQWHVEPMPPYFFPMRRYPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H125</accession>
    <name>A0AAJ0H125_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_488571</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725648.1">
        <property type="nucleotide sequence ID" value="XM_062866524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H125"/>
    <dbReference type="GeneID" id="87885353"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3309868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="270" mass="30882" checksum="165D3B7148963080" modified="2024-07-24" version="1">MAEPTNPPEQSHLPNAFVPGTLIANSVAQARHVDPAKVSNKHYPPGFKERWMEAYRGNPDVEHIQLSSRVKPRRWRHACKSPGINHVVDLVPADGVFREGITCPYLGCGYVTDADTPLVNGIGDPIETMRGLNLIDGVGPFNRFWRYWFECCRCTRWKSNDLLKIGDWRSRRKAVPDDNCEHCGVYVEIDCDYCVSYNFYKEPVEFMDGKPFPFGAVWRHKEVGGGKFHIVEDSDAGGWRILSRYPHGRGSWTGSEDWRLERIKKPESLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H1I6</accession>
    <name>A0AAJ0H1I6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Histone deacetylase</fullName>
            <ecNumber evidence="2 9">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0T15DRAFT_517289</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="2 9"/>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725853.1">
        <property type="nucleotide sequence ID" value="XM_062868305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H1I6"/>
    <dbReference type="GeneID" id="87887134"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000007">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF36">
        <property type="entry name" value="HISTONE DEACETYLASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037913">
        <property type="entry name" value="His_deacetylse_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="14">
        <location>
            <begin position="83"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="472"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="472"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR037913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3310073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="496" mass="56046" checksum="B57520ECAE53F6B5" modified="2024-07-24" version="1">MDATAYRYRPPKPNYLPHDIEVDHPVVEDYTLPLGTANDRENAIFFNKMKFAAQEYGIVRPKGYTVSYHATPEMEKHHFGLTHPMKPWRLTLTKSLVTSYGMPFAMDNYLTREATYEELSAFHSNDYLDYLITAEPEDQPRDIDNPDKEVKFNLGGSDCPLFHGLYDYCSMSAGSSLDAARKICSKQSDIAIAWGGGLHHAKKSEASGFCYINDIVLAILQLLRFYPRVLYIDIDVHHGDGVEEAFFSTDRVMTVSFHKYQPEHFFPGTGGLEDNGPKNEHNPGAHHAINVPLQDGITDEQYEALFKNVIGAINERYRPSAIALQCGADSLAGDRLGRFNLRVQGHGACVRYCKSLGLPMIMFGGGGYTPRNVARAWAYETSIAIGADTHIPETIPEHAPWRGHFIHDTLFPSLEQSMNEPRHNRNSEKRLREIVTHVHEQLRFVSHAPSVQSQRIPSDLEAIRDEVEARLKEEQEEKSDGLRTIREEGVGQALEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H2I6</accession>
    <name>A0AAJ0H2I6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cx9C motif-containing protein 4, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_518255</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CMC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726129.1">
        <property type="nucleotide sequence ID" value="XM_062868348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H2I6"/>
    <dbReference type="GeneID" id="87887177"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1130:FF:000008">
        <property type="entry name" value="Cx9C motif-containing protein 4, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1130">
        <property type="entry name" value="CytochromE C oxidase copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027179">
        <property type="entry name" value="CMC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15590">
        <property type="entry name" value="CX9C MOTIF-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15590:SF0">
        <property type="entry name" value="CX9C MOTIF-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08991">
        <property type="entry name" value="CMC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="13"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR627179-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3310349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="78" mass="8775" checksum="E2F587A06C766943" modified="2024-07-24" version="1">MGLEQDLRSDPPCHPRACAIQDCLTKTGYNEAKCAKYVDALYECCQTFYEKNGDSAVTVSCPKPNLLRLKMEQRKGTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H3I7</accession>
    <name>A0AAJ0H3I7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B0T15DRAFT_489700</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726847.1">
        <property type="nucleotide sequence ID" value="XM_062866620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H3I7"/>
    <dbReference type="GeneID" id="87885449"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF11">
        <property type="entry name" value="GLYCOSYLHYDROLASE FAMILY 61-7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042568434" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="17">
        <location>
            <begin position="20"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="18">
        <location>
            <begin position="296"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="253"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="269"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAK3311067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="332" mass="34612" checksum="27A189630D705BD3" modified="2024-07-24" version="1">MKGLLTVAAVSLAVSEASAHYIFQQLTTGGVKHDVFQYIRKNSNYNSPVTDLSSHDLRCNVGATGAGTDTVTVKAGDSFTFTLDTPVYHQGPVSLYMSKAPGKASDYDGSGPWFKIKDWAPDFSSGSATWNMAGSYTYNIPTCIPNGDYLLRIQSLGIHNPWPAGIPQFYISCAQITVTGGGNGNPGPTALIPGAFKETDPGYTANASPFLISPVPSSSTFDPSLPLPLASHLRIYSNFHNYTVPGPAVFSCNGGGANPSPDPSPSQNPTPTTLVTSTTTRAAPTTSSSSAPPSSCTVAKWGQCGGQGYSGCTACAAGSTCSKQNDYFSQCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H3V9</accession>
    <name>A0AAJ0H3V9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">IkappaB kinase</fullName>
            <ecNumber evidence="2">2.7.11.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0T15DRAFT_482318</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[I-kappa-B protein] + ATP = O-phospho-L-seryl-[I-kappa-B protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19073"/>
            <dbReference type="Rhea" id="RHEA-COMP:13698"/>
            <dbReference type="Rhea" id="RHEA-COMP:13699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.10" evidence="2"/>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727027.1">
        <property type="nucleotide sequence ID" value="XM_062866093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H3V9"/>
    <dbReference type="GeneID" id="87884922"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033209">
        <property type="term" value="P:tumor necrosis factor-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051180">
        <property type="entry name" value="IKK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22969">
        <property type="entry name" value="IKB KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22969:SF17">
        <property type="entry name" value="INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="217"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3311247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="449" mass="50285" checksum="82F34BDDB8D683C3" modified="2024-07-24" version="1">MDNPNIIVTLYPIVDTPTDATMITLRLHDDTSQYDWSQTPEPDEDDARNRSPEAAYPGLQLRYDHRRKLRSGFALGTSEGCNIRLPKARDVKGISGFQCIICFDAHDRLVLKDVRDVDPGTGKRVDGTAILSGADFADRSDGRQQILIYLHDNLCFRAVVPPRNHHPEDYRTRVAQFRQGATVDPHELPLTGLGLDGGESTAGVDTGMQTPSEGAIWLKRKTLGQGAFAVVTRVSNVSTGVDYARKQPVDGAYCDLERWRQEARLLRRISHEHIVRLVADDFSSSLPTLDLEYMQGRTLHWQSRVLQFSPAEVLMILDQGLAALAYLHELDPPIIHRDIKPANILVQHRTADHIHIKLTDFGHSKDGHELRTRCGTELYLASEIQANAATRHRAKRDPYTSAVDIWSLGVMVYKFGFGLPDLDLAEGPGWCQAIVEKLHMEDESALADF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H476</accession>
    <name>A0AAJ0H476_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_482309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727015.1">
        <property type="nucleotide sequence ID" value="XM_062866091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H476"/>
    <dbReference type="GeneID" id="87884920"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF294">
        <property type="entry name" value="POTENTIAL PROTEIN LYSINE METHYLTRANSFERASE SET6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="34"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3311235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="308" mass="32961" checksum="33EA63DF498AF908" modified="2024-07-24" version="1">MASAPRTTPNEVFDASKQAKAPSEFLCRAPRYAPAVRVGFVSPDVGYGLFAARDFARDEFIFDEAPAMTALFNEKFSGDKALMQSQLAACRGALASDPDVIALAFPSLAARLGVVPADFDQAARVLTSGELGKNLEHGRFAGSTVTRQEYESYIAGIKAKVVSSSSETDARNACLEFFKHYAFQVHQGAGPPRAGGGVATREACVYLLGSLVNHCCPAPSTSLASSKQNSCYSSSSVPPGPNCSWRIGPSGLAHFIKPRHICVQARRDICEGEQLTWDYGKQEKGFECECETCRSSFMSGLGQTCGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H4Q3</accession>
    <name>A0AAJ0H4Q3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NACHT-NTPase and P-loop NTPases N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_508221</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727462.1">
        <property type="nucleotide sequence ID" value="XM_062867705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H4Q3"/>
    <dbReference type="GeneID" id="87886534"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3311682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="224" mass="24768" checksum="85E7CDE85B5226DB" modified="2024-07-24" version="1">MDVIGSFAAVTQLAGQLVNLAQQIFRARETIRRAPKAIEDLDSQLWRLFNTSKQVADEPALQIKTIHEALEDIYDIALELQANVERMRKQQSKNRAFQLLHALVLGQRDESVLTDIVGRLRDAQDTLGHRINVAHVGTTAGMVEVVNRIEAGVVSIRRDVHGKVDQPQLDISNNMVGAATQENSIDVWEGVSLSRGVIKDNQAWNGSWQRNAISIGSNAIKCTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LXW8</accession>
    <name>A0AAJ0LXW8_9PEZI</name>
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        <recommendedName>
            <fullName evidence="7">Ankyrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_323585</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717567.1">
        <property type="nucleotide sequence ID" value="XM_062864078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LXW8"/>
    <dbReference type="GeneID" id="87882907"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051637">
        <property type="entry name" value="Ank_repeat_dom-contain_49"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24180">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR 2C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24180:SF45">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE TANKYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="601"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="152"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="738"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="152"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="738"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3301787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="774" mass="87026" checksum="D284EAD478DDF952" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ0LY32_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_325568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
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            <taxon>Sordariomycetes</taxon>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717643.1">
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    <dbReference type="AlphaFoldDB" id="A0AAJ0LY32"/>
    <dbReference type="GeneID" id="87882938"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3301863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ0LYA7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_577331</name>
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    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717971.1">
        <property type="nucleotide sequence ID" value="XM_062871057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LYA7"/>
    <dbReference type="GeneID" id="87889886"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3302191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="220" mass="23834" checksum="643C874F5DFFD2FB" modified="2024-07-24" version="1">MTDGLTKDEWQFPSPIPIQQDINEWLEMPEAHMCMILVVIYIKRRLSAAPASPKRPVAFRRPSEAQQYLDSWDVYGFLSDVGTTGTTGQLVALDPSSAAQTPHAAHIKDVKVEATVGGCHKFPDRGVGAVFSGAQVGCLAWQLAQPQRGSQLTGFDVGGDMPSSCVFLPVMTKARLSRYEQPPGDRTGQATDEQQHVAPFVHAPSVIGRCSDENSILNSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LYL7</accession>
    <name>A0AAJ0LYL7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_562310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718259.1">
        <property type="nucleotide sequence ID" value="XM_062870573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LYL7"/>
    <dbReference type="GeneID" id="87889402"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="400"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3302479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="486" mass="51301" checksum="018551B793B1CC7A" modified="2024-07-24" version="1">MSTAVAMAPSPGPHDRPSSYGSDLPSTTTSPAAQRTVAAPPPPPPANAAPSNASAAQPPRSGSGSPRAAGAAVNSQKSSRNGERPKIIVKKEPGSPGLPTARHRPKKLDLSRNTSIVSPATGRPLTAREGALGIQEVGIACLSPGFVPKDATEQEQLNRSMSVREHQRQIIEARLQQQSAKMGDGSEKDSNGSHFAAKTPGLARKRGAPPGLSIVAPSPQQFATERVIQSAPLGQSFTGRHNPHPLTRHITNQPSNLASTSHIHHVPATQTNNRLPPIADVFGQNLSGHPDSSGHALFANQNQNRGPLPSPHHPPPPPPQQTRSREYKSAEEAQVELAGGRPELLPKLVRYGGHQPPTPPSPPHPHARDQASHHHHHHQHPHGNQGHNHSRPPPPPGPAAPTAAPPTATAAAPTSSMKRRRDQYEEGGSPPLGNGARPAPAAPMPFSSMGARRGPFGEGRDSPDTIEAKKEEFLALCSRAWDLFHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LYM4</accession>
    <name>A0AAJ0LYM4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA recognition domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_514453</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718198.1">
        <property type="nucleotide sequence ID" value="XM_062868122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LYM4"/>
    <dbReference type="GeneID" id="87886951"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12236">
        <property type="entry name" value="RRM_snRNP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000298">
        <property type="entry name" value="U1 small nuclear ribonucleoprotein 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034143">
        <property type="entry name" value="snRNP70_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051183">
        <property type="entry name" value="U1_U11-U12_snRNP_70-35kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022023">
        <property type="entry name" value="U1snRNP70_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13952">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13952:SF5">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12220">
        <property type="entry name" value="U1snRNP70_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="102"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="66"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="234"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="242"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="354"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3302418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="385" mass="42398" checksum="D7A38E649E65CDF9" modified="2024-07-24" version="1">MTDRLPPNLLALFAPRPPLRWVPPCDHPPEQRRTAAVSGVAQYLPALAEYEREYEYHPTESWLEARDRKKREKQAQVEKMLTEGPRNYKPQEDPNIRGDAFKTLIVARLDYSADEKDLEREFGRFGPIERIRIIRDTHAHEKGNKKQKPHRGYGFVVFEREKDMRAALDGCDGIRIKDRRIKVDVERGRTVKGWKPRRLGGGLGGRGYTKAAMPRPMGPGGFGGGYRGGFSGGFRGRDRGFRGGGGGFGGDRGFRSGPGGPGRGGDFGSRGADRGFGGPSGPPNAPSGPGGGGYGGRDNRRDGPGGGGYGRDGGSRSYDDRSGGGYRDRNPRQSGSNMEPIRPRGENGGYSGGRDYDRPKDYDDSRKRGYEGGGYESDPRRIRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZ33</accession>
    <name>A0AAJ0LZ33_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">P-type Na(+) transporter</fullName>
            <ecNumber evidence="19">7.2.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">B0T15DRAFT_261333</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>K(+)(in) + ATP + H2O = K(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75815"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>Na(+)(in) + ATP + H2O = Na(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:14634"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IID subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.3" evidence="19"/>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718796.1">
        <property type="nucleotide sequence ID" value="XM_062863334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZ33"/>
    <dbReference type="GeneID" id="87882163"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008554">
        <property type="term" value="F:P-type sodium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02086">
        <property type="entry name" value="P-type_ATPase_Na_ENA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000015">
        <property type="entry name" value="Sodium ion P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000039">
        <property type="entry name" value="Sodium P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000047">
        <property type="entry name" value="Sodium P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006414">
        <property type="entry name" value="P-type_ATPase_IID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01523">
        <property type="entry name" value="ATPase-IID_K-Na"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0915">Sodium</keyword>
    <keyword evidence="17" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="238"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="718"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="755"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="796"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="843"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="894"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="927"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="23">
        <location>
            <begin position="44"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase C-terminal" evidence="24">
        <location>
            <begin position="748"/>
            <end position="948"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00035017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00035029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF00689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KAK3303016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="998" mass="109726" checksum="8CAA9DE2F4392F75" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZG9</accession>
    <name>A0AAJ0LZG9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dynactin subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_495938</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719159.1">
        <property type="nucleotide sequence ID" value="XM_062867134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZG9"/>
    <dbReference type="GeneID" id="87885963"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070840">
        <property type="term" value="F:dynein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027777">
        <property type="entry name" value="DCTN6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13072">
        <property type="entry name" value="DYNACTIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13072:SF0">
        <property type="entry name" value="DYNACTIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3303379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="193" mass="20075" checksum="50FA2728F3BB0D86" modified="2024-07-24" version="1">MSSKRHSILPPVSQSGPKPPVHFSSSITIADSALLTGTNLIVIHGESVIHPRAKLDSLAGRITVGRRCIVHERATLGAVGTSGKITEAAVTLGEYVTVEVGASIEAGETVIGEGTVVGVGARVGAGAVVGKHCTLTPHTEIAAGEVVPDFTVVYSNGMRRTDKRGVAELKNKGQARQIDVLRRMIPSNPAKFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZL1</accession>
    <name>A0AAJ0LZL1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glycerol kinase</fullName>
            <ecNumber evidence="3">2.7.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP:glycerol 3-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0T15DRAFT_402245</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="3"/>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719203.1">
        <property type="nucleotide sequence ID" value="XM_062865149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZL1"/>
    <dbReference type="GeneID" id="87883978"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046167">
        <property type="term" value="P:glycerol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07792">
        <property type="entry name" value="ASKHA_NBD_FGGY_GK1-3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000086">
        <property type="entry name" value="Glycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000085">
        <property type="entry name" value="Glycerol kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042018">
        <property type="entry name" value="GK1-3_metazoan-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005999">
        <property type="entry name" value="Glycerol_kin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01311">
        <property type="entry name" value="glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000756">
        <property type="entry name" value="PRK00047.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF69">
        <property type="entry name" value="GLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00933">
        <property type="entry name" value="FGGY_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 10 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="11">
        <location>
            <begin position="76"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="12">
        <location>
            <begin position="341"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3303423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="586" mass="64094" checksum="A7C094A6A06645EB" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZQ4</accession>
    <name>A0AAJ0LZQ4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor BYE1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_281938</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Negative regulator of transcription elongation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BYE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719456.1">
        <property type="nucleotide sequence ID" value="XM_062863589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZQ4"/>
    <dbReference type="GeneID" id="87882418"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001139">
        <property type="term" value="F:RNA polymerase II complex recruiting activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031440">
        <property type="term" value="P:regulation of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21538">
        <property type="entry name" value="SPOC_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000560">
        <property type="entry name" value="Putative PHD finger domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.30">
        <property type="entry name" value="Transcription elongation factor S-II, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055499">
        <property type="entry name" value="DUF7071"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012921">
        <property type="entry name" value="SPOC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003618">
        <property type="entry name" value="TFIIS_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036575">
        <property type="entry name" value="TFIIS_cen_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477:SF11">
        <property type="entry name" value="TRANSCRIPTION FACTOR BYE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477">
        <property type="entry name" value="TRANSCRIPTION FACTOR S-II ZINC FINGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23257">
        <property type="entry name" value="DUF7071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20826">
        <property type="entry name" value="PHD_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07744">
        <property type="entry name" value="SPOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07500">
        <property type="entry name" value="TFIIS_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00510">
        <property type="entry name" value="TFS2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46942">
        <property type="entry name" value="Elongation factor TFIIS domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51321">
        <property type="entry name" value="TFIIS_CENTRAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS central" evidence="9">
        <location>
            <begin position="226"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="130"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="357"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="432"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="660"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="800"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="317"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="660"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="710"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="803"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="827"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="862"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="885"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="897"/>
            <end position="907"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3303676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="907" mass="99332" checksum="AEE0267FF861FF5F" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M0R1</accession>
    <name>A0AAJ0M0R1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ADP/ATP translocase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ADP,ATP carrier protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B0T15DRAFT_537379</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane.</text>
    </comment>
    <comment type="function">
        <text evidence="16">Catalyzes the exchange of ADP and ATP across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ADP(in) + ATP(out) = ADP(out) + ATP(in)</text>
            <dbReference type="Rhea" id="RHEA:34999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:35000"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 16">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720494.1">
        <property type="nucleotide sequence ID" value="XM_062869610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M0R1"/>
    <dbReference type="GeneID" id="87888439"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140021">
        <property type="term" value="P:mitochondrial ADP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990544">
        <property type="term" value="P:mitochondrial ATP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000001">
        <property type="entry name" value="ADP,ATP carrier protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002113">
        <property type="entry name" value="ADT_euk_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635">
        <property type="entry name" value="ADP,ATP CARRIER PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635:SF14">
        <property type="entry name" value="ADP_ATP TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00927">
        <property type="entry name" value="ADPTRNSLCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0050">Antiport</keyword>
    <keyword evidence="11 14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="13"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="118"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="218"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU368008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK3304714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="315" mass="34394" checksum="34C1714E9B630D14" modified="2024-07-24" version="1">MSKETRQNVMGMPPFMVDFLMGGVSAAVSKTAAAPIERIKLLVQNQDEMIKAGRLDRRYNGIVDCFRRTTADEGVMALWRGNTANVIRYFPTQALNFAFRDKFKKMFGYKKDKDGYWKWMAGNLASGGAAGATSLLFVYSLDYARTRLANDAKSAKKGGERQFNGLIDVYRKTMATDGIAGLYRGFGPSVAGIVVYRGLYFGMYDSIKPVVLVGSLQNNFLASFLLGWCVTTGAGIASYPLDTVRRRMMMTSGEAVKYKSSFDAFQQIVAKEGVKSLFKGAGANILRGVAGAGVLSIYDQLQVLLFGKAFKGGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M0U2</accession>
    <name>A0AAJ0M0U2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_576178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720600.1">
        <property type="nucleotide sequence ID" value="XM_062871016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M0U2"/>
    <dbReference type="GeneID" id="87889845"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3304820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="418" mass="46460" checksum="7A9B4263F22FFEE1" modified="2024-07-24" version="1">MPLFSNGALKSLRNESAASLKAREEPAVPPRQPSITDRRRQCWWSQRSGHRRRGIQGRRRPITDSLVEPGRFALAAYVVIPGEPEYAAGKARAHVTSCRRKAQQQRRFLIGGLANAWKRVRSGRRENGHWCQIHSFATHKTAPITIVNKVDDAFLSRDFRFIDYSVISNRLLKTMAVEGWLMETWTASEKGRVVIMSAEQCPNETLSKLLLEPPKAASPTTAKAASEARPDVDLPNVNDFLKKLVTSGRRTERRTRTRKQHGQAKQVQDEIVVEPVQSSPDEDELDEHQPSTPTLQSEATDRSGSRTDGNITKTTNADSASQVTTSEQSVDDMDIDSLRMDPEEEPSRIAPISACAEVNNGLMSADPDRDLVADMSMANTLASDNPDWCAMTHFSMDADALKGCDALPYSIQAEPILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M0Y2</accession>
    <name>A0AAJ0M0Y2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Alpha-galactosidase</fullName>
            <ecNumber evidence="4 9">3.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Melibiase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0T15DRAFT_400416</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Hydrolyzes a variety of simple alpha-D-galactoside as well as more complex molecules such as oligosaccharides and polysaccharides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="4 9"/>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720704.1">
        <property type="nucleotide sequence ID" value="XM_062865058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M0Y2"/>
    <dbReference type="GeneID" id="87883887"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005995">
        <property type="term" value="P:melibiose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000202">
        <property type="entry name" value="Alpha-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000111">
        <property type="entry name" value="Glyco_hydro_27/36_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041233">
        <property type="entry name" value="Melibiase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452:SF75">
        <property type="entry name" value="ALPHA-GALACTOSIDASE MEL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17801">
        <property type="entry name" value="Melibiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ALPHA_GALACTOSIDASE"/>
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    </dbReference>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042534766" description="Alpha-galactosidase" evidence="10">
        <location>
            <begin position="22"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha galactosidase C-terminal" evidence="11">
        <location>
            <begin position="326"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
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        <source>
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        </source>
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        <source>
            <dbReference type="Pfam" id="PF17801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3304924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="399" mass="43136" checksum="4AB110759A8A7B72" modified="2024-07-24" version="1">MLNKLLVPLIVLFSRASSRTASEKRLDNGVGRTPALGWNSWNQGGCNAASATVVLNTAKAFVDLGLKDLGYTYVNIDDCWSAKQRNSTGHLVADTSKFPKGIDGLAREVHAMGLKLGLYGDAGTQTCALYPGSYGSEQKDADTLAAWGVDYWKFDNCLTEQVYTNKGIKSQQYYPIMRDALLKTGRPILFSICQWGRDEVWTWGGKVGNSWRMSEDIQNNWASVSSIAARAATMYQYAAPGGFNDLDMMELGNGVLTEAEERAHFGLWAIMKSPIIMGTDMTKLKASTLNIIKNKGILAIHQDPLGKAATTFTPKGQPAPVSGKLYRYYAGPLSDGVVVGLVAADGAETLTVNFSDVPGLGAGSFTWTELYSGRNGTGTSVSQRLATHDMAVFKVVTHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M162</accession>
    <name>A0AAJ0M162_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_188463</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720868.1">
        <property type="nucleotide sequence ID" value="XM_062862412.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87881241"/>
    <dbReference type="Proteomes" id="UP001273166">
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    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="von Willebrand factor, type A domain"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3305088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="729" mass="79277" checksum="260D2C0043D0FCEA" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M195</accession>
    <name>A0AAJ0M195_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_192493</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721049.1">
        <property type="nucleotide sequence ID" value="XM_062862461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M195"/>
    <dbReference type="GeneID" id="87881290"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046670">
        <property type="entry name" value="DUF6540"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20174">
        <property type="entry name" value="DUF6540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3305269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="146" mass="16742" checksum="1EDD8C6BE0C66DA3" modified="2024-07-24" version="1">MSYNVYLAESLGGGKSDHHAILVQRDVPSKTGEPHFLYQVKGSIAQGMTYEFREAREDDFMLGKTWLGTVDADDFNCIDRICSLVPPPKKQFDGPRRLYPREKLYKCQAWTRAALRALEAEGVLRCPHGIPWETIHESRRTDTWSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M1P1</accession>
    <name>A0AAJ0M1P1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_533233</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721511.1">
        <property type="nucleotide sequence ID" value="XM_062869356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M1P1"/>
    <dbReference type="GeneID" id="87888185"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13384">
        <property type="entry name" value="HTH_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3305731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="94" mass="10351" checksum="C7353B1ABAE32A9A" modified="2024-07-24" version="1" fragment="single">MVNLAEIGAKLTAGRQPGQELSPTARAAIIGAVAAGASQSAIARAFRIDRTAVYRILQRFESSTTVESKPRTGRPEILIYREKRYILQLAKRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M1Q5</accession>
    <name>A0AAJ0M1Q5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Eukaryotic translation initiation factor 2A</fullName>
            <shortName evidence="8">eIF-2A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_207542</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the WD repeat EIF2A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721512.1">
        <property type="nucleotide sequence ID" value="XM_062862635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M1Q5"/>
    <dbReference type="GeneID" id="87881464"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000596">
        <property type="entry name" value="Eukaryotic translation initiation factor 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011387">
        <property type="entry name" value="TIF2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017222">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Translation initiation factor beta propellor-like" evidence="10">
        <location>
            <begin position="216"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="474"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="524"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="541"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="579"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="627"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3305732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="692" mass="74808" checksum="32EF1C54143BFADA" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M2I8</accession>
    <name>A0AAJ0M2I8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nucleoporin NUP49/NSP49</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_412566</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722144.1">
        <property type="nucleotide sequence ID" value="XM_062865407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M2I8"/>
    <dbReference type="GeneID" id="87884236"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025574">
        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024882">
        <property type="entry name" value="NUP58/p45/49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13437">
        <property type="entry name" value="NUCLEOPORIN P58/P45 NUCLEOPORIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13437:SF2">
        <property type="entry name" value="NUCLEOPORIN P58_P45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13634">
        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21121">
        <property type="entry name" value="Nup49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="39"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="66"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="150"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3306364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="486" mass="49748" checksum="AD9636A08AF95F7E" modified="2024-07-24" version="1">MALARSASGPGGLSVNTGSSNLFGTNTSQAPAGGGLFGTATSQPAQGGSLFGTATSQPQQTGSLFGSTTTPASQPQQTGGLFGQTTGTTKPQQTGSLFGTATAQQQQPQSQQTGGGGLFGNTSSQPAQTGGLFGGATQAQPAQTGGLFGGSTTQQQQQQSQATGGLFGGQSSTTGGMFGAKPAGTTAGGGLFGQPAKPQTGGLFGASQQPQQQQPKQVGLTMGQSTAAQQQVVPGVRIDLSNIKSTTRFNDLQESLQKEIAMIDEVIQKCIKDKEVIDAFMPSHGDQLAAIPTDVSFVSRKSEGAHNALSSDIVAIDQLRELVKQDAGHARLSFKAIDNLKLPTQYHQAGLWSNRGQQVGGGAGAGGGVGVGVGVGDANEQSNSDLISYFSQTASEMDEMMRKLEQNLGEIEVHLHGVQGNILEQMQRVAAQSKSVAQGGVDERVIELAGVLRDFEESILKVAGVVGGVREGVTELQLKDFIGHGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M2L3</accession>
    <name>A0AAJ0M2L3_9PEZI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_528024</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722487.1">
        <property type="nucleotide sequence ID" value="XM_062869009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M2L3"/>
    <dbReference type="GeneID" id="87887838"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3306707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="83" mass="8910" checksum="1564F3784606C555" modified="2024-07-24" version="1">MVNLAEIGAKLTAGRQLGQELSPTARAAIIGAVAAGASQLAVARAFRIERTASKPQTGQPEILTCREKRYILQLAKRRPQLIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M2M9</accession>
    <name>A0AAJ0M2M9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3-hydroxyacyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_154689</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722606.1">
        <property type="nucleotide sequence ID" value="XM_062862035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M2M9"/>
    <dbReference type="GeneID" id="87880864"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075:SF3">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="101"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="3">
        <location>
            <begin position="299"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="153"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3306826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="421" mass="45680" checksum="6F0C93277F4DB00D" modified="2024-07-24" version="1">MLRMMSGLTPTTLAVGKRAFVARNLASYRALRPIFASDSAVVSRGSPLASLHRPVIPFSHSPRPYHSAFSTSAGLLNTATNGSQPPKWRPPSDESLNQRPVLVVGAGNIGRRVALVWASNNRPVTIYDISPDALHSATEYITDNLGSFCAERDTHPGQVRTTGDLRTATTTSGSPERNSAGDIAASEHTNAPWLAIECLPESLPLKASVLALLERSLPADCILASNSSSLTTAEMAAEGPLLHPHRLLNTHYFIPPRNRMVELMSSGETAAAIFPFLAAQMRRVGFVPVVMPRDIQSRGFIFNRIWAACKRETLAVLADGVAKPADVDALFRDFFHAEKGPCERMDEVGLDVVARVEQHHLERRPELGSAGHLAWLKVNYVQQGKLGEKSGDGLFTAEERIQLKENHRAGRHGAVDETAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M2N4</accession>
    <name>A0AAJ0M2N4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar protein sorting-associated protein 35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_150076</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays a role in vesicular protein sorting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the VPS35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722473.1">
        <property type="nucleotide sequence ID" value="XM_062861983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M2N4"/>
    <dbReference type="GeneID" id="87880812"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030906">
        <property type="term" value="C:retromer, cargo-selective complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.660:FF:000002">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.660">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 35, helical subcomplex Vps35-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005378">
        <property type="entry name" value="Vps35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042491">
        <property type="entry name" value="Vps35_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11099:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11099">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03635">
        <property type="entry name" value="Vps35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009375">
        <property type="entry name" value="Retromer_Vps35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="337"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3306693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="887" mass="99665" checksum="B5E60C6C2CD61380" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M2R5</accession>
    <name>A0AAJ0M2R5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">GPI ethanolamine phosphate transferase 1</fullName>
            <ecNumber evidence="14">2.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0T15DRAFT_566567</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.-.-.-" evidence="14"/>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722711.1">
        <property type="nucleotide sequence ID" value="XM_062870699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M2R5"/>
    <dbReference type="GeneID" id="87889528"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16020">
        <property type="entry name" value="GPI_EPT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000015">
        <property type="entry name" value="GPI ethanolamine phosphate transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007070">
        <property type="entry name" value="GPI_EtnP_transferase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017852">
        <property type="entry name" value="GPI_EtnP_transferase_1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037671">
        <property type="entry name" value="PIGN_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250:SF0">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04987">
        <property type="entry name" value="PigN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 14" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="459"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="495"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="550"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="586"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="610"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="637"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="677"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="716"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="741"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="841"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="880"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="936"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="domain" description="GPI ethanolamine phosphate transferase 1 C-terminal" evidence="15">
        <location>
            <begin position="449"/>
            <end position="924"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3306931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1000" mass="109965" checksum="1A67C4F95C3A40C2" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M2S8</accession>
    <name>A0AAJ0M2S8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_528540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722682.1">
        <property type="nucleotide sequence ID" value="XM_062869045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M2S8"/>
    <dbReference type="GeneID" id="87887874"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3306902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="82" mass="9339" checksum="39495FAC8F6EEB57" modified="2024-07-24" version="1">MASADVVAMLVYLILFLPLIFPNFVLFSLFCFFNHFLALYAHYRRDAVRPRLQARAAREAHGHVRPPPDGPSLRGYPAKLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M2W5</accession>
    <name>A0AAJ0M2W5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">pyridoxal 5'-phosphate synthase</fullName>
            <ecNumber evidence="4">1.4.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_529142</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.5" evidence="4"/>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722861.1">
        <property type="nucleotide sequence ID" value="XM_062869085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M2W5"/>
    <dbReference type="GeneID" id="87887914"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004733">
        <property type="term" value="F:pyridoxamine phosphate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000659">
        <property type="entry name" value="Pyridox_Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019740">
        <property type="entry name" value="Pyridox_Oxase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019576">
        <property type="entry name" value="Pyridoxamine_oxidase_dimer_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00558">
        <property type="entry name" value="pdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004231">
        <property type="entry name" value="PRK05679.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851:SF0">
        <property type="entry name" value="PYRIDOXINE-5'-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851">
        <property type="entry name" value="PYRIDOXINE-5-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10590">
        <property type="entry name" value="PNP_phzG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="PNPOx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01064">
        <property type="entry name" value="PYRIDOX_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase N-terminal" evidence="8">
        <location>
            <begin position="100"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridoxine 5'-phosphate oxidase dimerisation C-terminal" evidence="9">
        <location>
            <begin position="250"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3307081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="295" mass="32984" checksum="B4E2F28B98C66E2A" modified="2024-07-24" version="1">MNTSLRRLFLVPALARRTRFLSPRRMSLHPTQDGAKLIFAPAGTSRHLEIPTGPSHVDAGQFLKTEHRGGLKRSDLNPEDPIAQFHAWFNEASEPGSGVSHPETCTLSTAQLPSGRVSARVVYMKELDAKGFVIYSNFGTSGKARDLFGTEDGSSTGNPWASLVFWWESLERQVRVEGKASRIPAAESQAYFDTRVRGSRIGAWSSRQSAVLRPDTSIDGDDGRATLDRWVKETEAMFEGAEQIPVPDFWGGLRIVPERIEFWQGRQNRLHDRFVYDRVDGEDGAGKWSLERLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M2Y9</accession>
    <name>A0AAJ0M2Y9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.256</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Asparagine-linked glycosylation protein 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B0T15DRAFT_395623</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the third and last glucose residue from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide intermediate Glc(2)Man(9)GlcNAc(2)-PP-Dol to produce Glc(3)Man(9)GlcNAc(2)-PP-Dol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>an alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate = a alpha-D-Glc-(1-&gt;2)-alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29543"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="Rhea" id="RHEA-COMP:19512"/>
            <dbReference type="Rhea" id="RHEA-COMP:19522"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:132522"/>
            <dbReference type="ChEBI" id="CHEBI:132523"/>
            <dbReference type="EC" id="2.4.1.256"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:29544"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ALG10 glucosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.256" evidence="4"/>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722910.1">
        <property type="nucleotide sequence ID" value="XM_062864789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M2Y9"/>
    <dbReference type="GeneID" id="87883618"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106073">
        <property type="term" value="F:dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016900">
        <property type="entry name" value="Alg10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12989">
        <property type="entry name" value="ALPHA-1,2-GLUCOSYLTRANSFERASE ALG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12989:SF10">
        <property type="entry name" value="DOL-P-GLC:GLC(2)MAN(9)GLCNAC(2)-PP-DOL ALPHA-1,2-GLUCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04922">
        <property type="entry name" value="DIE2_ALG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="183"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="349"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="610"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="471"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK3307130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="649" mass="72257" checksum="956AD97610D35906" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M3A6</accession>
    <name>A0AAJ0M3A6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Eukaryotic translation initiation factor 3 subunit B</fullName>
            <shortName evidence="8">eIF3b</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Eukaryotic translation initiation factor 3 90 kDa subunit homolog</fullName>
            <shortName evidence="8">eIF3 p90</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Translation initiation factor eIF3, p90 subunit homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">PRT1</name>
        <name evidence="11" type="ORF">B0T15DRAFT_414601</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="8">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8 9">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the eIF-3 subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M3A6"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12278">
        <property type="entry name" value="RRM_eIF3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000419">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000235">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03001">
        <property type="entry name" value="eIF3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011400">
        <property type="entry name" value="EIF3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034363">
        <property type="entry name" value="eIF3B_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14068">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 EIF3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14068:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036424">
        <property type="entry name" value="eIF3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="42"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR036424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3307427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="750" mass="86102" checksum="849654AD1E232EE3" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M3C7</accession>
    <name>A0AAJ0M3C7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sulfate transporter family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_178937</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723223.1">
        <property type="nucleotide sequence ID" value="XM_062862275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M3C7"/>
    <dbReference type="GeneID" id="87881104"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.750.24:FF:000024">
        <property type="entry name" value="Sulfate permease 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018045">
        <property type="entry name" value="S04_transporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
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        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00815">
        <property type="entry name" value="sulP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SLC26A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="696"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3307443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="821" mass="88894" checksum="8356CEF55B2CB9C0" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M3E9</accession>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_554506</name>
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        <lineage>
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            <taxon>Sordariales</taxon>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
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                <person name="Ament-Velasquez S.L."/>
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                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
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                <person name="Hiltunen Thoren M."/>
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            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
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                <person name="Brannstrom I.O."/>
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
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                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
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                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
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                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723405.1">
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    <dbReference type="GeneID" id="87889185"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471:SF6">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-0170">Cobalt</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="NodB homology" evidence="8">
        <location>
            <begin position="588"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="187"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3307625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="799" mass="86981" checksum="10EE1163246D5CBA" modified="2024-07-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M416</accession>
    <name>A0AAJ0M416_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL22</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L17</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_490814</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724002.1">
        <property type="nucleotide sequence ID" value="XM_062866722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M416"/>
    <dbReference type="GeneID" id="87885551"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.470.10:FF:000010">
        <property type="entry name" value="60S ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="entry name" value="Ribosomal protein L22/L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_uL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018260">
        <property type="entry name" value="Ribosomal_uL22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005721">
        <property type="entry name" value="Ribosomal_uL22_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_uL22_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01038">
        <property type="entry name" value="uL22_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593:SF10">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="Ribosomal protein L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00464">
        <property type="entry name" value="RIBOSOMAL_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3308222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="194" mass="21705" checksum="930710C7AFC3653E" modified="2024-07-24" version="1">MGAMRGLVEVRYAATEIAPAKSARSRGSYLRVSFKNTRETAQAINGWKLQRAQTFLENVIEKKEAVPMRRYAGSIGRTAQGKQWGVSRARWPVKSAQFLLGLLKNAEANADAKGLDTGNLIVKHIQVNQAPKQRRRTYRAHGRINPYMSNPCHIELILTEADEAVQKSEAVVRDESHLSSRQRGVRVRRAITAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M423</accession>
    <name>A0AAJ0M423_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_524005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724050.1">
        <property type="nucleotide sequence ID" value="XM_062868736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M423"/>
    <dbReference type="GeneID" id="87887565"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3308270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="183" mass="21082" checksum="68DDFCB6B3375288" modified="2024-07-24" version="1">MPGLFHGYHFHCHPRLVPSISREDALLLEPTLNSRRLGTIRPLAWSVLTTEHDEAPWVVPATVHCDVLAAAWSSCWCTGLFVASDHHPLTRPRRCCREFKRDIFDLFDRHPKLHLFDPTIEPSRPVTSSDAMLRFRGTDATYYQVDFDEYDPDTSPWVVKPLTRGDMNVLEYARSLDDLLYCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M480</accession>
    <name>A0AAJ0M480_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoesterase family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_107897</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724212.1">
        <property type="nucleotide sequence ID" value="XM_062861454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M480"/>
    <dbReference type="GeneID" id="87880283"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956:SF8">
        <property type="entry name" value="ACID PHOSPHATASE PHOA (AFU_ORTHOLOGUE AFUA_1G03570)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="NON-SPECIFIC PHOSPHOLIPASE C4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042507136" evidence="2">
        <location>
            <begin position="18"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3308432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="309" mass="33572" checksum="66518398DCD6583E" modified="2024-07-24" version="1">MALLHLSLLGLLGGAAAQTQYTSTAVSAVAKAAATALTLSPTSNVAGNKFERFVQIFLENVDYSKAIADPNLGFLATQGISLTNYFAITHPSQPNYVAAVGANTFGVTDDGFRSIGSTTETIVDLLEPKGVSWGLYQEDMPYSGFEGNWVNQRTGKNDYVRKHNPLMSFDSVTSNTNRLARCKNFTMFDRDLAANTLPQWMFITPNMTNDGHDSSVTVAGRWARNWLTPLLSNPKFNIDRTLVILTFDEGSTVGTNQIYAVLLGSAIPSAKVGTTNSTRYDHYSLTKTVELNWNLGSLGQHDVGASAFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M4A3</accession>
    <name>A0AAJ0M4A3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_103549</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724049.1">
        <property type="nucleotide sequence ID" value="XM_062861396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M4A3"/>
    <dbReference type="GeneID" id="87880225"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052594">
        <property type="entry name" value="J_domain-containing_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44144">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44144:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="8"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="500"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3308269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="604" mass="70319" checksum="271EC5BE4035F840" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M4E7</accession>
    <name>A0AAJ0M4E7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Guanyl-nucleotide exchange factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_390537</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724452.1">
        <property type="nucleotide sequence ID" value="XM_062864546.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87883375"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1000.11:FF:000002">
        <property type="entry name" value="Cytohesin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF405">
        <property type="entry name" value="ARF GUANINE NUCLEOTIDE EXCHANGE FACTOR SYT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
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<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Ng V."/>
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                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725922.1">
        <property type="nucleotide sequence ID" value="XM_062863341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M620"/>
    <dbReference type="GeneID" id="87882170"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17919">
        <property type="entry name" value="DEXHc_Snf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="417"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="784"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="29"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="106"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="355"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="675"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="210"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="355"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3310142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="963" mass="107746" checksum="9DEDD5ABA2BA10D5" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M647</accession>
    <name>A0AAJ0M647_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_518680</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726283.1">
        <property type="nucleotide sequence ID" value="XM_062868383.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87887212"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047499">
        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046486">
        <property type="term" value="P:glycerolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07216">
        <property type="entry name" value="Pat17_PNPLA8_PNPLA9_like3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185:SF1">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3 4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="6">
        <location>
            <begin position="12"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1375"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="4">
        <location>
            <begin position="16"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="4">
        <location>
            <begin position="56"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1375"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3310503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1420" mass="161002" checksum="AEDEB7503D1E8B51" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M698</accession>
    <name>A0AAJ0M698_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Uracil-DNA glycosylase</fullName>
            <shortName evidence="7">UDG</shortName>
            <ecNumber evidence="7">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">UNG1</name>
        <name evidence="11" type="ORF">B0T15DRAFT_44777</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="7"/>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M698"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097510">
        <property type="term" value="P:base-excision repair, AP site formation via deaminated base removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10027">
        <property type="entry name" value="UDG-F1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.470.10:FF:000007">
        <property type="entry name" value="Uracil-DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="entry name" value="Uracil-DNA glycosylase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00148">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002043">
        <property type="entry name" value="UDG_fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018085">
        <property type="entry name" value="Ura-DNA_Glyclase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003588">
        <property type="entry name" value="PRK05254.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003589">
        <property type="entry name" value="PRK05254.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003592">
        <property type="entry name" value="PRK05254.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00628">
        <property type="entry name" value="ung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264:SF0">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00987">
        <property type="entry name" value="UreE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="Uracil-DNA glycosylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00130">
        <property type="entry name" value="U_DNA_GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uracil-DNA glycosylase-like" evidence="10">
        <location>
            <begin position="123"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="307"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="366"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="315"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="341"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="366"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="384"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="406"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3310653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="418" mass="45849" checksum="40AF31BC03F6A1A9" modified="2024-07-24" version="1">MSTLKRKAAAQAGAEAKKSKQGSIMSFFGATNPSSTGGSANKSAAPEPAGPKFDKAQWVASLTPEQRQLLQLEIDTLHDSWLALLKDELVTKEFLELKRFLNRETAAGRKWFPPAEDVYSWSRHTPFNTVKVVILGQDPYHNVNQAHGLAFSVRPPTRAPPSLKNMYICLKNDYPSFNPPPNKGGLLTPWADRGVLMLNTCLTVRAHEANSHSNRGWERFTQKCIDLVAARRTRGVVFMAWGTPAGKRVLRVDGKRHLVLKTVHPSPLSASNGYFTCRHFRLANDWLAERYGPGGRVDWALVEGESVFDEEQGEEEGKKEEKEKEGVEEQKKGKEERGFNEDDEEFGDGDAADMLEAVVKAEAGVKAAASSAAAAAPGENSNPAEKEAVVVEKRKTRSQKAVAEAADGEENAAPEVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M6C3</accession>
    <name>A0AAJ0M6C3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WLM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_41642</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726329.1">
        <property type="nucleotide sequence ID" value="XM_062865470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M6C3"/>
    <dbReference type="GeneID" id="87884299"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013536">
        <property type="entry name" value="WLM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053000">
        <property type="entry name" value="WSS1-like_metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46622">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46622:SF1">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08325">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51397">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="WLM" evidence="5">
        <location>
            <begin position="10"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="245"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="320"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="328"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3310549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="447" mass="49500" checksum="EE17BA8736EF2642" modified="2024-07-24" version="1">MPLGIQRLNAKRSQPNDRIVFIKPLKGPDEKIAQDFLERIAAQCLPIMREHHLSVMSLEEYEPNREFVGRNFNAGEVIQLVLKTHSGHWLPFNYVQMVMMHELAHCKQMNHSRAFWAVRNQYAEQMRSLWARGFTGEGLWGRGALLSTGEFERNTVAPGEPLPEHLCGGTYRSRSRKRKAKKVLSYKEQKERRILKKFGAGGVKLGEDEEVKKKLEKGKAKAAKPRVAGSARGRELRAAAALARFEQQKTEEVMDEADEGSETESGDDYEDDDTTPGTDALDIDGKKLLDSKGRRMVKVCEDENPEDQDAQQELRELQSFGSMKLVQKPSNSARGGESPSKSVPKTAANKAQAPAGRESAKSEPPISIDGSPAEPNPLGPKNCPVCTFANEPQSATCAMCASVLDPDRITDSWACKSRTCQGSNYRNAGDCGVCGVCGERRPPPEFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M6C4</accession>
    <name>A0AAJ0M6C4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="7">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_481986</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="7"/>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726521.1">
        <property type="nucleotide sequence ID" value="XM_062866061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M6C4"/>
    <dbReference type="GeneID" id="87884890"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08598">
        <property type="entry name" value="PI-PLC1c_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.190:FF:000039">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF82">
        <property type="entry name" value="PHOSPHOINOSITIDE PHOSPHOLIPASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PI-PLC Y-box" evidence="9">
        <location>
            <begin position="404"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="229"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="258"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3310741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="683" mass="77821" checksum="B4DD7AA418A406BD" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M6E0</accession>
    <name>A0AAJ0M6E0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">tRNA synthetases class II-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_518652</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726267.1">
        <property type="nucleotide sequence ID" value="XM_062868379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M6E0"/>
    <dbReference type="GeneID" id="87887208"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="entry name" value="GAD-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00044">
        <property type="entry name" value="Asp_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004524">
        <property type="entry name" value="Asp-tRNA-ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00459">
        <property type="entry name" value="aspS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF5">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="8">
        <location>
            <begin position="255"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="172"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3310487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="761" mass="85003" checksum="F1903652742D982A" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M6L2</accession>
    <name>A0AAJ0M6L2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH-ubiquinone oxidoreductase 9.5 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_489470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726599.1">
        <property type="nucleotide sequence ID" value="XM_062866602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M6L2"/>
    <dbReference type="GeneID" id="87885431"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22903">
        <property type="entry name" value="NI9M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039961">
        <property type="entry name" value="Nuo9.5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38488">
        <property type="entry name" value="OXIDOREDUCTASE 9.5 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G08980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38488:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 9.5 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G08980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3310819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="80" mass="8812" checksum="C7538DB1BA362AA6" modified="2024-07-24" version="1">MNGATPRFWAGPLRYCRWAARERPGLFWAVAIGAMGPVTLVTVPPIRRMIGDEDAAPIPLTYPVPSGPRKKLTGYDDDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M778</accession>
    <name>A0AAJ0M778_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anaphase-promoting complex subunit 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cyclosome subunit 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_409300</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727230.1">
        <property type="nucleotide sequence ID" value="XM_062865349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M778"/>
    <dbReference type="GeneID" id="87884178"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037679">
        <property type="entry name" value="Apc5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026000">
        <property type="entry name" value="Apc5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12830">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12830:SF9">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12862">
        <property type="entry name" value="ANAPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042533607" description="Anaphase-promoting complex subunit 5" evidence="9">
        <location>
            <begin position="23"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 5" evidence="10">
        <location>
            <begin position="281"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3311450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="783" mass="88204" checksum="01361095F71E52EE" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GKI6</accession>
    <name>A0AAJ0GKI6_9PEZI</name>
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        <recommendedName>
            <fullName evidence="5">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_317092</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717377.1">
        <property type="nucleotide sequence ID" value="XM_062864008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GKI6"/>
    <dbReference type="GeneID" id="87882837"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025187">
        <property type="entry name" value="DUF4112"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35519">
        <property type="entry name" value="MEMBRANE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35519:SF2">
        <property type="entry name" value="PH DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13430">
        <property type="entry name" value="DUF4112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3301597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="271" mass="29655" checksum="3AAFC5F1416C4B0B" modified="2024-07-24" version="1">MSSLALKLLERRAFGKLQSEKRSTNSDNPYEHRVPVFKNGKCVGHKTEKRPIPEGLSRNDVKILKKVRKRAYRWDMGFSCCCLGFRFGWSSIIGLFPVIGDFADLFMALALIKKASKVDGGLPKRLYSMMFTNIMIDFALGFIPVLGDIVDVFYRANTRNAWLLDAYLTEKAKALREGVITDPDGGSKVRVPSELQVAPGDRDLEEGIGPVAVAEPTPVPPAVTPARTPAPVGTMAPPSRAPAPGRSLTGQRTPGPGLPGRQIKDPRDRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GKM3</accession>
    <name>A0AAJ0GKM3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_320923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717456.1">
        <property type="nucleotide sequence ID" value="XM_062864048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GKM3"/>
    <dbReference type="GeneID" id="87882877"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3301676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="929" mass="101246" checksum="2F4B99631B7BA9E0" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GKS5</accession>
    <name>A0AAJ0GKS5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Scytalone dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_544513</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the scytalone dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717530.1">
        <property type="nucleotide sequence ID" value="XM_062870088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GKS5"/>
    <dbReference type="GeneID" id="87888917"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049884">
        <property type="entry name" value="Scytalone_dh"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02982">
        <property type="entry name" value="Scytalone_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Scytalone dehydratase-like" evidence="3">
        <location>
            <begin position="6"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3301750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="128" mass="14608" checksum="DD85F7CD3995D32A" modified="2024-07-24" version="1">MPPLTTIQIDYRGVIGKLWEAIPAAEFITLAASAKFLGDRRLQTQHFIGGAAKWVRTGDDAITGYHQMRVAHQRYKDDERKEVLCKGHCHGKATVRYRKVEEGGVWKLAGMEPDIRWTEGEFDKVFPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GKV5</accession>
    <name>A0AAJ0GKV5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_404946</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717576.1">
        <property type="nucleotide sequence ID" value="XM_062865275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GKV5"/>
    <dbReference type="GeneID" id="87884104"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3301796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="545" mass="62722" checksum="F61C3B6F8F2CAE84" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GKX1</accession>
    <name>A0AAJ0GKX1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">T6SS Phospholipase effector Tle1-like catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_563375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717565.1">
        <property type="nucleotide sequence ID" value="XM_062870612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GKX1"/>
    <dbReference type="GeneID" id="87889441"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF1">
        <property type="entry name" value="TLE1 PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="2">
        <location>
            <begin position="19"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="384"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="407"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3301785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="668" mass="73679" checksum="16B2D94942BC574E" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GL34</accession>
    <name>A0AAJ0GL34_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FACT complex subunit POB3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0T15DRAFT_439769</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the SSRP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3301916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717696.1">
        <property type="nucleotide sequence ID" value="XM_062865898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GL34"/>
    <dbReference type="GeneID" id="87884727"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035101">
        <property type="term" value="C:FACT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="PH1_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13231">
        <property type="entry name" value="PH2_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13229">
        <property type="entry name" value="PH_TFIIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.220:FF:000003">
        <property type="entry name" value="FACT complex subunit POB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000146">
        <property type="entry name" value="FACT complex subunit POB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000310">
        <property type="entry name" value="FACT complex subunit POB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.150:FF:000001">
        <property type="entry name" value="Fact complex subunit ssrp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.220">
        <property type="entry name" value="Structure-specific recognition protein (SSRP1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="RTT106/SPT16-like_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050454">
        <property type="entry name" value="RTT106/SSRP1_HistChap/FACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048993">
        <property type="entry name" value="SSRP1-like_PH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000969">
        <property type="entry name" value="SSRP1/POB3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035417">
        <property type="entry name" value="SSRP1/POB3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024954">
        <property type="entry name" value="SSRP1_DD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038167">
        <property type="entry name" value="SSRP1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849:SF1">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21103">
        <property type="entry name" value="PH1_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17292">
        <property type="entry name" value="POB3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rttp106-like_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03531">
        <property type="entry name" value="SSrecog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00887">
        <property type="entry name" value="SSRCOGNITION"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone chaperone RTT106/FACT complex subunit SPT16-like middle" evidence="12">
        <location>
            <begin position="372"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="482"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="501"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="537"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3301916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="569" mass="63787" checksum="BC809AA220B4BFB5" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GL63</accession>
    <name>A0AAJ0GL63_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_569336</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3301964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717744.1">
        <property type="nucleotide sequence ID" value="XM_062870807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GL63"/>
    <dbReference type="GeneID" id="87889636"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3301964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="259" mass="29870" checksum="0F19B2B8E1727553" modified="2024-07-24" version="1">MPVLSEIRYSREATVAAVTGYFDFLAKMYLNEADILRPPEGGWPEIMPQRLKGLGKTDEVTLLLRHLPYIRPNYAISGPDAGPCGVQFYCWLDPIRSLDLTGQESQDSEEEFDTMKFMTEGGHRDVIPSHVVGLTSSEDLEDLFMLDTQLGVIYWLECPGRIWHHPTRERIEDDAYDYAAEDEADWRNYPAFAIADFFELLKDQFRQLDVIPISPSRVLDPTLQAIYREHSWPDLDRYQKEECLKAVGAMARERYPISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GL91</accession>
    <name>A0AAJ0GL91_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_514033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3301962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717742.1">
        <property type="nucleotide sequence ID" value="XM_062868091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GL91"/>
    <dbReference type="GeneID" id="87886920"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3301962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="115" mass="12453" checksum="019BA91A60D999FA" modified="2024-07-24" version="1">MDKSCIKKASFHLICPCLSLAPLSLPHSSQPRSFEVTANNQDYKDYIAEPSPSVVQTPAQKPPARQQRAARLISTAGPKFNASFGDPADEFILRKACSRPSVKSSPGRGKAQNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GLG4</accession>
    <name>A0AAJ0GLG4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Acireductone dioxygenase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Acireductone dioxygenase (Fe(2+)-requiring)</fullName>
            <shortName evidence="11">ARD'</shortName>
            <shortName evidence="11">Fe-ARD</shortName>
            <ecNumber evidence="11">1.13.11.54</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Acireductone dioxygenase (Ni(2+)-requiring)</fullName>
            <shortName evidence="11">ARD</shortName>
            <shortName evidence="11">Ni-ARD</shortName>
            <ecNumber evidence="11">1.13.11.53</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ADI1</name>
        <name evidence="12" type="ORF">B0T15DRAFT_292110</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14161"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:17245"/>
            <dbReference type="ChEBI" id="CHEBI:49016"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.53"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24504"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16723"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.54"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
        <text evidence="11">Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the acireductone dioxygenase (ARD) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.54" evidence="11"/>
    <dbReference type="EC" id="1.13.11.53" evidence="11"/>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GLG4"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010308">
        <property type="term" value="F:acireductone dioxygenase (Ni2+-requiring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010309">
        <property type="term" value="F:acireductone dioxygenase [iron(II)-requiring] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02232">
        <property type="entry name" value="cupin_ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000079">
        <property type="entry name" value="1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03154">
        <property type="entry name" value="Salvage_MtnD_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004313">
        <property type="entry name" value="ARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027496">
        <property type="entry name" value="ARD_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418:SF0">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03079">
        <property type="entry name" value="ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11 12" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8 11" id="KW-0408">Iron</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="3 11" id="KW-0533">Nickel</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3302111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="172" mass="20340" checksum="5F4CEA8D5621B422" modified="2024-07-24" version="1">MKAYFYDNLPGDQRLPHDSGTALSESELSSIGVLYYRIPELSGVDALAAERGYKNRDEITVSPEKMGDAYESKVKMFFDEHLHEDEEIRYVRDGRGYFDVRDRDDRWVRIQLEKDDLIILPAGIYHRFTTDETNYIHAMRLFKEEPKWTPLNRSNELDTNPYRKEYVSQYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GLY8</accession>
    <name>A0AAJ0GLY8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_542852</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718188.1">
        <property type="nucleotide sequence ID" value="XM_062869947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GLY8"/>
    <dbReference type="GeneID" id="87888776"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3302408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="155" mass="17178" checksum="44F5C4DFDE22C3A4" modified="2024-07-24" version="1">MFRREAPTMGECPVGSAAGGRPCFQILRYVHSSWAHRDPTARRSSTHPSSQHGNSLELVSELARLLFLLLGCLHAALKRLVFSYTSPIVLILPESKRLFSISSIRVGHEACDPTANKLFPMALTVTEMPKAGTQHIRCWIHSLTATRTSDEGREP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GM69</accession>
    <name>A0AAJ0GM69_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_496986</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718306.1">
        <property type="nucleotide sequence ID" value="XM_062867231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GM69"/>
    <dbReference type="GeneID" id="87886060"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 4" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="6">
        <location>
            <begin position="218"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="4">
        <location>
            <begin position="220"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="297"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="349"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="129"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="374"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3302526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="383" mass="43535" checksum="348881BBD797B7B4" modified="2024-07-24" version="1">MEPLRDSRRANLPPLRELLSRLDQIDPRPQETGPRGYPPTGPDTANGSSPATPQGHYTLSPPQPHELNRPKWFQTQEERESRDHWRHLPGRYPTPPRDAPPPALSSSAPPPRPPVDRWMSSPYSQGHPDIQRGPDIPTDHSHSRFGSFHEGHGPGGYRNEEYCDRRYDQGGAYVHGHYDGVRGGSQIYDGRGYDPRPSGPGSAGSHQPDSPAIPAHQARGKRNRPNLPKEAVDIMMAWVDDHIENPYEREDRPELIRRTGLEERRVIHWFTNFRRRKWHKHRVDFYSREVSKAKAARHAAEEEAARNPPCSAAAEAARRAADAAARRAAEAEAARSAAEKNYLRAKERWESWEDDQKRKRGAEREVKRKAGLLVDDDSEDDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GMJ9</accession>
    <name>A0AAJ0GMJ9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_577582</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718265.1">
        <property type="nucleotide sequence ID" value="XM_062871060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GMJ9"/>
    <dbReference type="GeneID" id="87889889"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="5">
        <location>
            <begin position="141"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="381"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3302485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="644" mass="73014" checksum="AC34096B9596E9D2" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GMM2</accession>
    <name>A0AAJ0GMM2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glycine--tRNA ligase</fullName>
            <ecNumber evidence="4">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Diadenosine tetraphosphate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0T15DRAFT_313845</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 ATP + H(+) = P(1),P(4)-bis(5'-adenosyl) tetraphosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:34935"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58141"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="4"/>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718522.1">
        <property type="nucleotide sequence ID" value="XM_062863963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GMM2"/>
    <dbReference type="GeneID" id="87882792"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070150">
        <property type="term" value="P:mitochondrial glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00774">
        <property type="entry name" value="GlyRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.200:FF:000001">
        <property type="entry name" value="Glycine--tRNA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000004">
        <property type="entry name" value="Glycine--tRNA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000010">
        <property type="entry name" value="Glycyl-tRNA synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033731">
        <property type="entry name" value="GlyRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002315">
        <property type="entry name" value="tRNA-synt_gly"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00389">
        <property type="entry name" value="glyS_dimeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003211">
        <property type="entry name" value="PRK04173.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745:SF0">
        <property type="entry name" value="GLYCINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="GLYCYL-TRNA SYNTHETASE/DNA POLYMERASE SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01043">
        <property type="entry name" value="TRNASYNTHGLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="190"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3302742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="652" mass="73116" checksum="29D584DBDD907B00" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GMU8</accession>
    <name>A0AAJ0GMU8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_400971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3302831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718611.1">
        <property type="nucleotide sequence ID" value="XM_062865084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GMU8"/>
    <dbReference type="GeneID" id="87883913"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3302831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="349" mass="37320" checksum="40140E2A9037E932" modified="2024-07-24" version="1">MSLPWSEALASFGTSAIDSRSSECKLSPAASAFSAMLSAFIGSVVNGLTNGWVVAFMTGWIAWLAIFRVLIGGLYMFYHGITDTWGPGRSSDFVDPPIPATAYDSHHRDESRIADENVYTGGWQAIPEPEREGQPSKLPLGMDLDRKVTALGWVSLVYTAVFAPITQILFVAANASRNDNGSAKLVKGLTVAVTALPLCIDCRVRYADSLKWGRYAFNVFLSLSCLLQGGISAALLITGVVDLSRGGDGGLPLPAVVVVYLAFSFLWMAASVALLPMRDGKRKGAGTTHWVMYILDVGMGAFAGVFLAAPAFALYQGATFANDSSGMSDLVTYLSCERQGWRRFAAVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GNF7</accession>
    <name>A0AAJ0GNF7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_539475</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718974.1">
        <property type="nucleotide sequence ID" value="XM_062869735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GNF7"/>
    <dbReference type="GeneID" id="87888564"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF57">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="254"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="44"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="294"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="319"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="367"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3303194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="400" mass="43202" checksum="8605A3D86A28D349" modified="2024-07-24" version="1">MKIASTEAAPRSLETTIPIENGRQVAMIVTSTLAIVVPTILVGLRFWAGRMIRRRLDASDVCIVAALVFTIGLHIDMYVMVLLGGFGFHGGEIVQRFGPDTLMLFLKGILAFPIIWNFTICFSKLSVLLMYTSVIPVREMVTACRVVGLLIVLWNSGGVLGALLLCRPIALNWDKYLPGTCGDNWLFYIWLGGINVVVEAVILLLPVPFIYRLQMKTFKKLVVIGLFSVGWMTCAVTIYRQASLPHLYFEDMTYTGVLATIFTGIEPAVALSLACVPFLRPLIYRNGGNNSNNNFSTGSDNSQYASAGGGSTTLRSKRGGGAGRSGARSGKGGGPSKEEHDDNDDSSEIQLRPLEGSGELRYEADVSPGGRRGPTPTGSTEGAIMVRKGWDVVSGVRPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GNM0</accession>
    <name>A0AAJ0GNM0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_538931</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718825.1">
        <property type="nucleotide sequence ID" value="XM_062869707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GNM0"/>
    <dbReference type="GeneID" id="87888536"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058925">
        <property type="entry name" value="zf-C2H2_AcuF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391:SF7">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26082">
        <property type="entry name" value="zf-C2H2_AcuF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3303045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="583" mass="65875" checksum="ECC00D6C09C67172" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GNM6</accession>
    <name>A0AAJ0GNM6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mannan endo-1,6-alpha-mannosidase</fullName>
            <ecNumber evidence="4 10">3.2.1.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0T15DRAFT_438264</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Random hydrolysis of (1-&gt;6)-alpha-D-mannosidic linkages in unbranched (1-&gt;6)-mannans.</text>
            <dbReference type="EC" id="3.2.1.101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 76 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.101" evidence="4 10"/>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718865.1">
        <property type="nucleotide sequence ID" value="XM_062865867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GNM6"/>
    <dbReference type="GeneID" id="87884696"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008496">
        <property type="term" value="F:mannan endo-1,6-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000006">
        <property type="entry name" value="Mannan endo-1,6-alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014480">
        <property type="entry name" value="Mannan-1_6-alpha_mannosidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145:SF36">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016302">
        <property type="entry name" value="Man_a_manosd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 10 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042575463" description="Mannan endo-1,6-alpha-mannosidase" evidence="12">
        <location>
            <begin position="26"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="446"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR016302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3303085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="474" mass="51466" checksum="4E03B58858B94575" modified="2024-07-24" version="1">MGWTLAAKATALLGSLLLAAAGATAQGAGKLQVNLDSSDEIKNAAKLVAENLMTYYHGDEPGQTPGILPGPPPGGPYYWWQAGAMWGTIIDYWFYTGDTTYNDEALRSMVFQAEPPANSYMPRNWTASLGNDDQGFWGMAAMSAAETNFQNPPEGQPQWLALAQAVFNTQAARWDTNTCNGGLHWQIPHTNGGYNYKNTIAQVVFLNLAARLARYTKNETYAKWADTAYDWTRGVGYITDDWNVLDGGHEEYNCTDINPVQFSANKALLIHGAAIMYNYTNGSDKWKTRVEGLLNHTIEFFFPEGIMVERACELEDRVQCNVDQHSFKGYMHRSLATVAIVAPFTRDAILKVLRSSTEGAVSSCLDDGTCGFRWNTGSYDGDVDKGPAGQQMSVLAALSTLLINQQKVLEGPLTNDTGGTSKGDPNAGIDYNEITPLAPITTGDRAGAGIVTVVVLTTLLGSLVWMGMGWSEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GP64</accession>
    <name>A0AAJ0GP64_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_486785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719110.1">
        <property type="nucleotide sequence ID" value="XM_062866385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GP64"/>
    <dbReference type="GeneID" id="87885214"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14011">
        <property type="entry name" value="PK_SCY1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051177">
        <property type="entry name" value="CIK-Related_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984:SF6">
        <property type="entry name" value="SCY1-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984">
        <property type="entry name" value="SCY1-RELATED S/T PROTEIN KINASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="729"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="790"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="832"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="982"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="729"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="790"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="804"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="832"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="884"/>
            <end position="907"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3303330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1006" mass="107340" checksum="32F44B3C47B8831E" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GPD3</accession>
    <name>A0AAJ0GPD3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome b-c1 complex subunit 6, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Complex III subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0T15DRAFT_495987</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UQCRH/QCR6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719215.1">
        <property type="nucleotide sequence ID" value="XM_062867143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GPD3"/>
    <dbReference type="GeneID" id="87885972"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.20:FF:000003">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.20">
        <property type="entry name" value="Ubiquinol-cytochrome C reductase hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003422">
        <property type="entry name" value="Cyt_b-c1_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023184">
        <property type="entry name" value="Ubol_cytC_Rdtase_hinge_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036811">
        <property type="entry name" value="Ubol_cytC_Rdtase_hinge_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15336:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15336">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 7.8 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02320">
        <property type="entry name" value="UCR_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81531">
        <property type="entry name" value="Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ubiquinol-cytochrome C reductase hinge" evidence="12">
        <location>
            <begin position="72"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3303435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="138" mass="15359" checksum="2E1AC7A575EF11D5" modified="2024-07-24" version="1">MGFWDTITDLVEAATPWATADAEAPARESTEETTAESTKEEASTEAQAAAEEEPAAEEEEEEEEEEEEEVVDPKEQLEEECRNSKQCAPAKHHFDECVERVTNQQAEGGAKEDCVEEFFHLAHCATQCAAPKLWSILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GPK1</accession>
    <name>A0AAJ0GPK1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">NADH-ubiquinone oxidoreductase 30.4 kDa subunit-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_279852</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the complex I 30 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719360.1">
        <property type="nucleotide sequence ID" value="XM_062863563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GPK1"/>
    <dbReference type="GeneID" id="87882392"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.80:FF:000002">
        <property type="entry name" value="NADH dehydrogenase iron-sulfur protein 3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="entry name" value="NADH:ubiquinone oxidoreductase, 30kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01357">
        <property type="entry name" value="NDH1_NuoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010218">
        <property type="entry name" value="NADH_DH_suC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020396">
        <property type="entry name" value="NADH_UbQ_OxRdtase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01961">
        <property type="entry name" value="NuoC_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004733">
        <property type="entry name" value="PRK06074.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10884:SF14">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10884">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="Nqo5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00542">
        <property type="entry name" value="COMPLEX1_30K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase 30kDa subunit" evidence="10">
        <location>
            <begin position="108"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="258"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3303580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="290" mass="32814" checksum="54CDB5B4BA5B6E6E" modified="2024-07-24" version="1">MATKLCRSRALASVLRPAKPSIATRSDVVVRCFATTAARADVAVPKDAPNPRAAPRDHVGTLKAPLVNPADKFQSKADDLHKYGSWLMGCLPKFIQQFSVWKDELTIYICPSGVIPVFSFLKYNTAAEFTAISDITAVDFPTRDQRFEVVYNLLSVRHNARIRVKTYADEVTPVPSITSIYEGANWYEREVYDLFGVFFVGHPDLRRIMTDYGFEGHPLRKDFPVTGYTEIRYDEEKKRIVTEPLELTQAFRNFEGGSSAWEQIGPGVDRTPDTFKLPTPKPEEKTEEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GPY6</accession>
    <name>A0AAJ0GPY6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin-like ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_417764</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3303984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719764.1">
        <property type="nucleotide sequence ID" value="XM_062865498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GPY6"/>
    <dbReference type="GeneID" id="87884327"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10207">
        <property type="entry name" value="ASKHA_NBD_Arp10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="275"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="414"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="275"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3303984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="563" mass="61715" checksum="9DEDC18E520EBA22" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQN4</accession>
    <name>A0AAJ0GQN4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_399339</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719915.1">
        <property type="nucleotide sequence ID" value="XM_062864997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQN4"/>
    <dbReference type="GeneID" id="87883826"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05227">
        <property type="entry name" value="AR_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000191">
        <property type="entry name" value="Methylglyoxal reductase (NADPH-dependent)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="4"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3304135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="343" mass="36884" checksum="5611F3CB7119AA5C" modified="2024-07-24" version="1">MSTVGGSGFIAAHVLDQLLAKGHSVVTTVRSEEKAAKIREAYPSQAASGDLAVAIVPDIAQPDAFDEVVKTPGLEVVLHTASPFHFKWTDAKKELIDPAVIGTTSILRAIARSAPTVRRVVVTSSFAAILDEAHIADGSHTFSEASWNPVTLADIHRSPATAYRASKTLAERAAWEFVRDPASGAKFDLVTVNPPMVFGPVLQHNVGSLDAVNTSNERVVDLLRGKWKEEVPSTGAAVIWIDVRDVAAAHVKAGLEAPEAGGKRLFTTAGLFSNAELAQIVRRRFPEYADRLPTEQTKGGELPAEGERYKFDNSATTRLLGIEWTPFEKCVVDTVESLKKLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQU0</accession>
    <name>A0AAJ0GQU0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome c-type biogenesis protein H TPR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0T15DRAFT_558190</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CYC8/SSN6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720217.1">
        <property type="nucleotide sequence ID" value="XM_062870462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQU0"/>
    <dbReference type="GeneID" id="87889291"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017053">
        <property type="term" value="C:transcription repressor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000403">
        <property type="entry name" value="General transcriptional repressor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000078">
        <property type="entry name" value="Transcriptional corepressor Cyc8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051630">
        <property type="entry name" value="Corepressor-Demethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056413">
        <property type="entry name" value="TPR_CcmH_CycH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14017:SF1">
        <property type="entry name" value="LD02225P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14017">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12895">
        <property type="entry name" value="ANAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23914">
        <property type="entry name" value="TPR_CcmH_CycH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4 9" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Cytochrome c-type biogenesis protein H TPR" evidence="11">
        <location>
            <begin position="41"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="42"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="110"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="146"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="183"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="220"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="293"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="327"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="430"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="530"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="551"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="580"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="600"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="658"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="674"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="711"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="793"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="809"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="821"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="831"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="850"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="862"/>
            <end position="873"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3304437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="884" mass="98393" checksum="991367B8ACA17AC7" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQZ5</accession>
    <name>A0AAJ0GQZ5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_485966</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720065.1">
        <property type="nucleotide sequence ID" value="XM_062866327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQZ5"/>
    <dbReference type="GeneID" id="87885156"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="94"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3304285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="693" mass="76432" checksum="CD63B4B670C1C380" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GR05</accession>
    <name>A0AAJ0GR05_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bms1-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_235683</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. TSR1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720080.1">
        <property type="nucleotide sequence ID" value="XM_062863012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GR05"/>
    <dbReference type="GeneID" id="87881841"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012948">
        <property type="entry name" value="AARP2CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039761">
        <property type="entry name" value="Bms1/Tsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007034">
        <property type="entry name" value="BMS1_TSR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030387">
        <property type="entry name" value="G_Bms1/Tsr1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858:SF1">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN TSR1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08142">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04950">
        <property type="entry name" value="RIBIOP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22298">
        <property type="entry name" value="Tsr1_G-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00785">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01362">
        <property type="entry name" value="DUF663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51714">
        <property type="entry name" value="G_BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Bms1-type G" evidence="6">
        <location>
            <begin position="88"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="328"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="409"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="31"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="328"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="409"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3304300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="829" mass="92500" checksum="A25C0A0A23FA02B2" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GR13</accession>
    <name>A0AAJ0GR13_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Velvet factor-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_486122</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the velvet family. VeA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720339.1">
        <property type="nucleotide sequence ID" value="XM_062866335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GR13"/>
    <dbReference type="GeneID" id="87885164"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF14">
        <property type="entry name" value="DEVELOPMENTAL AND SECONDARY METABOLISM REGULATOR VEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0749">Sporulation</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Velvet" evidence="10">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="125"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="202"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="125"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="344"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="354"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="366"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="449"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3304559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="502" mass="55610" checksum="C75E7D1EB917FC0B" modified="2024-07-24" version="1">MEAHSSLALGSRFPAASADRRPVDPPPVVELRIYEGQTWEIAQEKDVTFVYNANFFLFATLEHARIMAHARGTPAANTPPVLTGMPVSGMAYLDRPQEAGYFLFPDLSVRHEGRYKLTFNLYEETKEDKDKDQEREGESQPPIPGVNPATGGSFDFRMEVKSQEFIVYSAKKFPGLAESTALSRVVAEQGCRVRIRRDVRMRRRDGKGTGDYDNAEDEYSRRRRTATPVDTRPDYNRARSMSGSTERTPYSAADPQRRPSMADYPSGYSQNPPPGGHLQFLGGNASSQYPAAPPPSFAQPPSVPASPVYPPSQAAPYPMQSSFPPPPPPPTAKSHSRERTPSQPGYPPINPAPPRRESVQHDYRPQLPPPSLPAHRPPTPQQRQMPPLKPQLPPLHIDNGIPSVARLPMPSPTTLGALPRPLAALTSSSKGPVHPATLPPPPQYAGSKRARDQTFRQEEEQPRFQDGAREKATAEDIRGDYERAMLFKRADGRISQSIHLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GR48</accession>
    <name>A0AAJ0GR48_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA-splicing endonuclease subunit Sen54 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_536346</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEN54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720155.1">
        <property type="nucleotide sequence ID" value="XM_062869544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GR48"/>
    <dbReference type="GeneID" id="87888373"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024337">
        <property type="entry name" value="tRNA_splic_suSen54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024336">
        <property type="entry name" value="tRNA_splic_suSen54_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21027">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21027:SF1">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12928">
        <property type="entry name" value="tRNA_int_end_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA-splicing endonuclease subunit Sen54 N-terminal" evidence="4">
        <location>
            <begin position="34"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="340"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="345"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3304375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="370" mass="41040" checksum="8A48FEA682507C65" modified="2024-07-24" version="1" fragment="single">MEEKEKEKEKEGGGKDGEEAGREKKPYGHIRERVVVLEWSSPASHSLGRAVTGQAKDRPARGKDWLLPEEALYLVERGSLDLWWPLKGIEEIFPPEGMAVEEEAEEADEYEMGFPLSLQAAYALLIGNDGERGKISLQKFQVYSNLKRCGYNVLRAPPVSRQPTPPTRMPITTTLWQWFSTLLTTSPQHLPYGPLVQPGLYRSYASIYRQMALLPRHKPSTSSQQTITTAEPFTIHFHIWKAAQKWTKLRHPPPDFRLAVVDAQQSAVPSLSEISALLAATPPAPGKPEWTGHPGRLYARLKHGHRNVLVAVVDHGVINYMRCAEAAFGLEELYARFDAPRGAGRKTGGGRNGNGGRGGRGGGRGRGRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GR51</accession>
    <name>A0AAJ0GR51_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_248496</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720394.1">
        <property type="nucleotide sequence ID" value="XM_062863138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GR51"/>
    <dbReference type="GeneID" id="87881967"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037473">
        <property type="entry name" value="Lcp-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37539:SF1">
        <property type="entry name" value="ER-BOUND OXYGENASE MPAB_MPAB'_RUBBER OXYGENASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37539">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="452"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic" evidence="2">
        <location>
            <begin position="130"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3304614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="479" mass="52797" checksum="CC771E8308687227" modified="2024-07-24" version="1">MTSPRPENGSRVRAWDYDFKWTPTHCTAAELRPLVFSYDELATRCLDRFDHLLGPSARAKSKTGKEGAANACAHSGFPDLYELLRTRAPEDDTLQELWDQVNTVPYWVDWDQIERGQRVFYRYAGPSVVGLIFQSLLGGLASARIVETLTRTGGFGVCVARRRLLETSQHILDVTDSLPSIQPGGKGFASSIRVRFLHASVRRRILALARERPTYYSIPSHGIPINDLDSIGTILAFSAAQIWIAFPRQGIFLTAAEIEDYLALWRYVAYLLGVPPTPYLSSPDAARTMMESLIFSELDPSPASQVLANNMLQSMAHQPPLYPSAAFLRAEAHWLNGHALADALAVPRPGVWQTLLVAGQCLVFMAVCYTRRSVRRWDEAGIARARRVLRSLVVKEGIAAYGGGGEAMHELKYVPSLDRIITAAAVGEKRGDQRAGGRVTMGDGVELRNLKAVLVACVVVGWVVGLGVRGVLGMLQKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GRN6</accession>
    <name>A0AAJ0GRN6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0T15DRAFT_558965</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720651.1">
        <property type="nucleotide sequence ID" value="XM_062870492.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87889321"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000209">
        <property type="entry name" value="Polyketide synthase Pks12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056501">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF29">
        <property type="entry name" value="ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23114">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="11">
        <location>
            <begin position="11"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="12">
        <location>
            <begin position="1023"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="2621"/>
            <end position="2698"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="8">
        <location>
            <begin position="1023"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="8">
        <location>
            <begin position="1193"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2583"/>
            <end position="2618"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="8">
        <location>
            <position position="1056"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="8">
        <location>
            <position position="1267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3304871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2705" mass="292307" checksum="D7BCBEA039A8C06B" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GRQ4</accession>
    <name>A0AAJ0GRQ4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B0T15DRAFT_251099</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 15">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 15">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720485.1">
        <property type="nucleotide sequence ID" value="XM_062863181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GRQ4"/>
    <dbReference type="GeneID" id="87882010"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000005">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000008">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="16">
        <location>
            <begin position="49"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="17">
        <location>
            <begin position="248"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK3304705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="449" mass="50053" checksum="C622B4A89964C268" modified="2024-07-24" version="1">MREIISLNVGQAGCQIANSCWELYCLEHGIQPDGFLTEERKQADPDHGFSTFFSETGNGKYVPRTIYCDLEPNVVDEVRTGAYRGLFHPEHMITGKEDASNNYARGHYTVGKELIDQVLDKVRRVADNCSGLQGFLVFHSFGGGTGSGFGALLMERLSVDYGKKSKLEFCVYPAPQTATSVVEPYNSILTTHTTLEHADCSFMVDNEAIYDICRRNLGLERPNYENLNRLIAQVVSSITASLRFDGSLNVDLNEFQTNLVPYPRIHFPLVAYAPVISAAKAAHEANSVQEMTMSCFEPNNQMVKCDPRHGKYMATCLLYRGDVVPNDAHAAVATLKTKRTIQFVDWCPTGFKLGICYQPPHQVPNGDLAKVNRAVCMLSNTTAIAEAWSALSSKFDLMYSKRAFVHWYVGEGMEEGEFSEAREDLAALERDYEEVAADSMEGEEVEAEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GRU8</accession>
    <name>A0AAJ0GRU8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Enolase C-terminal domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_538237</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720754.1">
        <property type="nucleotide sequence ID" value="XM_062869675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GRU8"/>
    <dbReference type="GeneID" id="87888504"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008869">
        <property type="term" value="F:galactonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034194">
        <property type="term" value="P:D-galactonate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03325">
        <property type="entry name" value="D-galactonate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034593">
        <property type="entry name" value="DgoD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023592">
        <property type="entry name" value="Galactonate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018110">
        <property type="entry name" value="Mandel_Rmase/mucon_lact_enz_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010624">
        <property type="entry name" value="PRK14017.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080:SF2">
        <property type="entry name" value="D-GALACTONATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080">
        <property type="entry name" value="D-GALACTONATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00003">
        <property type="entry name" value="D-galactonate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00179">
        <property type="entry name" value="mandelate_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00908">
        <property type="entry name" value="MR_MLE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mandelate racemase/muconate lactonizing enzyme C-terminal" evidence="5">
        <location>
            <begin position="126"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3304974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="381" mass="42193" checksum="A9D6481B6B08B66E" modified="2024-07-24" version="1">MGRIASMEYFRVPPRWLFVKITDELGNVGWGEASLEGHTQAVEGCLDAWFERYKGMDPDDIEHIWQMSWRTSFYRGGPVFMSALAGIDIALWDLKARKLGVPIYQLLGGKLRDKLRVYAWIGGDRPGDVEAQALARKAQGFHAVKMNATEDLGWLDSPEALQSCVDRVKTVKSLGMDAGIDFHGRVHLPMAKQLVKALEPHSPFFVEEPLLSEHIAGIKSLHQLTSCPIALGERLHSRWDVRPFLEAGCVDVLQPDISHVGGISEMRRIAVMAETYDVALAPHCPLGPIALAANFQVDIVSANFAIQEMSLGIHYNSTGQDITSYITNPDVWKVEDGYVAIPTGPGLGVEIDEQQVRALSKDEKPWISPGFIGPGGEIREW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GS98</accession>
    <name>A0AAJ0GS98_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_484882</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720966.1">
        <property type="nucleotide sequence ID" value="XM_062866252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GS98"/>
    <dbReference type="GeneID" id="87885081"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031359">
        <property type="entry name" value="NACHT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF14">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17100">
        <property type="entry name" value="NACHT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="3">
        <location>
            <begin position="425"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="9"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3305186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1097" mass="124687" checksum="27EB141BAFAA671C" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GSL1</accession>
    <name>A0AAJ0GSL1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U3 small nucleolar ribonucleoprotein protein MPP10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_532048</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
            <location evidence="1 7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the MPP10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721132.1">
        <property type="nucleotide sequence ID" value="XM_062869291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GSL1"/>
    <dbReference type="GeneID" id="87888120"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012173">
        <property type="entry name" value="Mpp10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17039">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN MPP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17039:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN MPP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04006">
        <property type="entry name" value="Mpp10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017300">
        <property type="entry name" value="snoRNP_Mpp10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 7" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="167"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="386"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="682"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="167"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="310"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="343"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="354"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="389"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="408"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="693"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR017300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3305352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="764" mass="84457" checksum="451AF784A9328C80" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GSS7</accession>
    <name>A0AAJ0GSS7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">WD40 repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_198354</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721249.1">
        <property type="nucleotide sequence ID" value="XM_062862544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GSS7"/>
    <dbReference type="GeneID" id="87881373"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055525">
        <property type="entry name" value="DUF7099"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055526">
        <property type="entry name" value="DUF7100"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055527">
        <property type="entry name" value="DUF7101"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23388">
        <property type="entry name" value="DUF7099"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23391">
        <property type="entry name" value="DUF7100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23392">
        <property type="entry name" value="DUF7101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7100" evidence="3">
        <location>
            <begin position="7"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7101" evidence="4">
        <location>
            <begin position="348"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7099" evidence="2">
        <location>
            <begin position="631"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1036"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="622"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3305469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1056" mass="116261" checksum="186C1654E7E25E54" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GSW6</accession>
    <name>A0AAJ0GSW6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="8">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_493689</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the peptidase C12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="8"/>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721311.1">
        <property type="nucleotide sequence ID" value="XM_062866963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GSW6"/>
    <dbReference type="GeneID" id="87885792"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF16">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE ISOZYME L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52049">
        <property type="entry name" value="ULD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="10">
        <location>
            <begin position="97"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="357"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="213"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="7">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3305531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="456" mass="50292" checksum="8086B62591DFFBD2" modified="2024-07-24" version="1">MAEEQKPTDSSGETGPESCEANPPVTLRRSGRVRRRPSDHIDNGAQESRGPATTSSSTSARRNPKRKAAPETFDVPDNLLEASLAPWKENELTEWEGWTELESDPAFFTLVLGLLGVKGARIVEALSVDEDSLAALPSPVYGLVFLYQYLGEESGKETAETGRDVWFANQTTNNACATIALLNIIMNVDGLSLDLLNAALALDNKVDRALTAKKSKKSNKRVKRRRAGSAESEGGSGYHFIAFVPRGQRVWLLDGLSSAPVCIGEYAQDQHWTSVMRPVLQERMMRYETEQLSFSLLALCGDDLGHVRQKLSANIRCLESIAAKLASSPEWNPKASSDIIYSSTDARLSLYQLDTQDVKGVPDPEPDPPLSNLHESSEIDSQTTEAASKLWEQLGDEQKGLRLQYEGSLNMDEHESARVFGRTKDYAPAIHEWVKILADRGVLKELHDQVQLSKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GTJ2</accession>
    <name>A0AAJ0GTJ2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acyl-CoA dehydrogenase/oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_211961</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721624.1">
        <property type="nucleotide sequence ID" value="XM_062862686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GTJ2"/>
    <dbReference type="GeneID" id="87881515"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF28">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="7">
        <location>
            <begin position="2"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="78"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3305844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="543" mass="60702" checksum="22A94BF4EB1FC2EF" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GTL3</accession>
    <name>A0AAJ0GTL3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_494066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721716.1">
        <property type="nucleotide sequence ID" value="XM_062866990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GTL3"/>
    <dbReference type="GeneID" id="87885819"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3305936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="271" mass="29624" checksum="2E69B4B6065BD426" modified="2024-07-24" version="1">MGTDTSQTSDTNATNQEGTVHAKDLRDTVPKTDDRSEEDVSSIATPVSRNTSLDFISSPTTPLTLSPSDVAYPGPGEALPTSDFETTNGEYARDNANNFNGDQLAYVLREWEANDNYYMTFPANDGFQSPKLVWIAYTTSHYEGIAYGKPKRAAATLANPAMKRFAMSIPDNPRPLPEPVSNDYAIMPGLDDYGIERSAEYDNDDYVDSENDEWDGDLPDVADRGRVDGIEKDAALSEWDESDGVVDEGLEEVDITAPPLSGRLADDTSEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GTM2</accession>
    <name>A0AAJ0GTM2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ca2+ regulator and membrane fusion protein Fig1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_211574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721614.1">
        <property type="nucleotide sequence ID" value="XM_062862681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GTM2"/>
    <dbReference type="GeneID" id="87881510"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000747">
        <property type="term" value="P:conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033481">
        <property type="entry name" value="Dni1/Fig1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016509">
        <property type="entry name" value="Fig1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28092">
        <property type="entry name" value="FACTOR-INDUCED GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28092:SF1">
        <property type="entry name" value="FACTOR-INDUCED GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12351">
        <property type="entry name" value="Fig1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007138">
        <property type="entry name" value="FIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3305834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="266" mass="29143" checksum="F5C6D9946C425382" modified="2024-07-24" version="1">MATRFQLGWYRWVPFLGYHHVLMILIAVAIILLSLLLAGCSSSSPLIPDIFLLSLYYQRYTAVPDTAQVDYNVNNAIANIVGSARLQARVGFFGICVSPDGGSWLCSNNATTLANEVSVDQDPLNLIWLASQFKDMIVFPYLLIIAIIFAFICLLLLATFPGWHEEEDSEGSEREVKPFPSRPVSQVALAIIFIASIFVLVSVLWQHTASVAASIIAQDLANGSVLSGVGSSAMVMGWFSFTLLIIVTIGLLVMILSMQVLEHIMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GU01</accession>
    <name>A0AAJ0GU01_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_534203</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3306057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721837.1">
        <property type="nucleotide sequence ID" value="XM_062869423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GU01"/>
    <dbReference type="GeneID" id="87888252"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050889">
        <property type="entry name" value="Dendritic_Spine_Reg/Scaffold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166:SF48">
        <property type="entry name" value="PROTEIN VAPYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166">
        <property type="entry name" value="ROLLING PEBBLES, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="3"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="36"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3306057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="90" mass="9916" checksum="7C44E9BC21FBDA44" modified="2024-07-24" version="1" fragment="single">DNNGRTPLLYAAWSGHEAVVRLLLEKGADRDAKDVFGRRSLLYAAWSGREAVVQLLLEKGADREEKDGIGRTPLLHAAQDGHEAVVRLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GU47</accession>
    <name>A0AAJ0GU47_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_396585</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3306119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721899.1">
        <property type="nucleotide sequence ID" value="XM_062864846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GU47"/>
    <dbReference type="GeneID" id="87883675"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057026">
        <property type="entry name" value="Znf-C2H2_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24537">
        <property type="entry name" value="zf-C2H2_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="458"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="338"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3306119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="602" mass="66325" checksum="EEFF17E762E2C193" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GU87</accession>
    <name>A0AAJ0GU87_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Intradiol ring-cleavage dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_512074</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3306246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722026.1">
        <property type="nucleotide sequence ID" value="XM_062867955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GU87"/>
    <dbReference type="GeneID" id="87886784"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03457">
        <property type="entry name" value="intradiol_dioxygenase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315:SF2">
        <property type="entry name" value="ANCHORED DIOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01800)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042560075" evidence="2">
        <location>
            <begin position="19"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Intradiol ring-cleavage dioxygenases" evidence="3">
        <location>
            <begin position="135"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3306246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="402" mass="42835" checksum="E68B0052DC4C588C" modified="2024-07-24" version="1">MVGISKLAVALLAASATAHPGESHDAHQMKREIVARDHAARVAARLLGSCANTEAARALKQRSIQRRAEVVKTLREKKSIKTPPKKYRRDLEALEVWEEINHNMTGVSANNMFTALETVFDANTSCILAPEVTDGPYYIVGEYLRSNVKEAQYSDGVDLFLEVQYVDVNTCEPVPTVAVDLWNCNATGVYSGISTSGNYAADGYNSTYLRGIQLTDHDGVAQFETIFPGHYDGRATHTHLLAHTNATVMPNGTISVWHAPVAHIGQLFWPEALRSAVEAVYPYNTNAQSVTSNADDMWSIVQADANYDPFPHFVYLGEDITDGLFAWIQIGINASADYSADDYYSVAAYIDADGGHAMSGGMGSGGGGMGGGPGGGNGTTNGTAPSGDMPTGGVPPSPVPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GUM7</accession>
    <name>A0AAJ0GUM7_9PEZI</name>
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        <submittedName>
            <fullName evidence="3">Glycosyl hydrolase catalytic core-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_136306</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722060.1">
        <property type="nucleotide sequence ID" value="XM_062861815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GUM7"/>
    <dbReference type="GeneID" id="87880644"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071966">
        <property type="term" value="P:fungal-type cell wall polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000207">
        <property type="entry name" value="Glycoside hydrolase family 128 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053183">
        <property type="entry name" value="ASL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024655">
        <property type="entry name" value="Asl1_glyco_hydro_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154:SF3">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11790">
        <property type="entry name" value="Glyco_hydro_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042607994" evidence="1">
        <location>
            <begin position="25"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Asl1-like glycosyl hydrolase catalytic" evidence="2">
        <location>
            <begin position="40"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3306280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="328" mass="36080" checksum="1AE899DFF34C60D9" modified="2024-07-24" version="1">MLPCSAALVALLAALPSFVLPAAADSSSKRGLVHTPNETTRADDTIWVQKPTDLTWYYNYKPEPESAFQDIPQSEFEFVPMLWGAPASLDDTSFLSTVRSLIEDKKINITHVLSFNEPDGPFAYGGSNMEPADAAQVWVKNMIPLQQMGIRVGLPACTGGPGGIPWLQNFLSECSKLVSTGDKTQNCTYDFVTIHWYGNFEGLASHMGQYSATFPNKTMWITEYNIDNQDLQTTQAFFNMSADYFDRLDFVERYSYFGAFRSDVSNVGPNGAMLSADGNLTDIGAWYLGRQATGVQPSQGESWGFRSAVPHASVALLSAWLIMLLVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GUR8</accession>
    <name>A0AAJ0GUR8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mss4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_527533</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722331.1">
        <property type="nucleotide sequence ID" value="XM_062868981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GUR8"/>
    <dbReference type="GeneID" id="87887810"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052355">
        <property type="entry name" value="CENP-V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28620:SF1">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28620">
        <property type="entry name" value="CENTROMERE PROTEIN V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="4">
        <location>
            <begin position="12"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="CENP-V/GFA" evidence="4">
        <location>
            <begin position="149"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3306551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="293" mass="32372" checksum="39AB1E8FC4890573" modified="2024-07-24" version="1">MPETEESPTRTYRGNCHCGAFVFEFEAAEIKAAGECNCSICSKRGYLFMEPQKPLTIVKDEGKLVHYTFGSGKIDHQFCGSCGIGVIGTSDLFPAGVGINVRAIQDLDIWGLEVTSYDGNLKKFGPPYEPPKYLGPEPNPPGFENGKTYYGSCHCKAVTAAVRVNGSLEDGSYKELIVECNCSICQRGAYVWIYPALNQVAIQGQENLSYYTLGNRVWRKSFCKTCGVHIGADLNPDLTAEEIAALPEPVRNFRTAYSDKRPLNLRILNGFDVKCVKPVRTDGWSRPPLYVNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GVQ7</accession>
    <name>A0AAJ0GVQ7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein ARV</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0T15DRAFT_393667</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Regulates also the sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Golgi apparatus membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ARV1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722826.1">
        <property type="nucleotide sequence ID" value="XM_062864697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GVQ7"/>
    <dbReference type="GeneID" id="87883526"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097036">
        <property type="term" value="P:regulation of plasma membrane sterol distribution"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007290">
        <property type="entry name" value="Arv1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14467">
        <property type="entry name" value="ARV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14467:SF0">
        <property type="entry name" value="PROTEIN ARV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04161">
        <property type="entry name" value="Arv1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 10" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="759"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="118"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="283"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="379"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="553"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="32"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="325"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="380"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="406"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="420"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="565"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3307046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="916" mass="98647" checksum="446CA12EA66BBF47" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GVT9</accession>
    <name>A0AAJ0GVT9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">DUF221 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0T15DRAFT_161725</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722797.1">
        <property type="nucleotide sequence ID" value="XM_062862114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GVT9"/>
    <dbReference type="GeneID" id="87880943"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022257">
        <property type="entry name" value="PHM7_ext"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF20">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12621">
        <property type="entry name" value="PHM7_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="720"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="768"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="813"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="862"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="936"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="974"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1008"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="12">
        <location>
            <begin position="46"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="13">
        <location>
            <begin position="234"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="13">
        <location>
            <begin position="623"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="10">
        <location>
            <begin position="718"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="domain" description="10TM putative phosphate transporter extracellular tail" evidence="11">
        <location>
            <begin position="1173"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="308"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="434"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="281"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="308"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="368"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="453"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="493"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3307017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1253" mass="139017" checksum="63AA131399DE463B" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GW81</accession>
    <name>A0AAJ0GW81_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AP-3 complex subunit beta-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_172093</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723061.1">
        <property type="nucleotide sequence ID" value="XM_062862207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GW81"/>
    <dbReference type="GeneID" id="87881036"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030123">
        <property type="term" value="C:AP-3 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026740">
        <property type="entry name" value="AP3_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037096">
        <property type="entry name" value="AP3_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="7">
        <location>
            <begin position="37"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="704"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="704"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="734"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3307281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="792" mass="87669" checksum="36E74103D62D7ECD" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GWR7</accession>
    <name>A0AAJ0GWR7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Carbon catabolite repressor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B0T15DRAFT_180513</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in carbon catabolite repression. Represses the transcription of a number of genes by binding to a GC-rich region in their promoter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the creA/MIG C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723279.1">
        <property type="nucleotide sequence ID" value="XM_062862301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GWR7"/>
    <dbReference type="GeneID" id="87881130"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000433">
        <property type="term" value="P:carbon catabolite repression of transcription from RNA polymerase II promoter by glucose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043609">
        <property type="term" value="P:regulation of carbon utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000089">
        <property type="entry name" value="DNA-binding protein creA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000152">
        <property type="entry name" value="DNA-binding protein creA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051007">
        <property type="entry name" value="creA/MIG_C2H2-ZnF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47428">
        <property type="entry name" value="REGULATORY PROTEIN MIG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47428:SF1">
        <property type="entry name" value="REGULATORY PROTEIN MIG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="97"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="18"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="109"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="206"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="381"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="161"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="250"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="271"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="327"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00077756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK3307499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="406" mass="44023" checksum="DB3170F79182722F" modified="2024-07-24" version="1">MQRAKSAVDFSSLLNPEVAADGDLASPSQHPNQQQSEADMATAGLIRPNGPVPAGAPPAEQPTELPRPYKCPMCDKAFHRLEHQTRHIRTHTGEKPHACQFPGCSKRFSRSDELTRHSRIHNNPNSRRGNKSHPQHAGMIQRLQPEVMAPPPGPKMIRSAPPTTLSSPNVSPPHYSSYNLNLPPPLNLGPYNRSQSGPDMAMLARAAGQADRDGQHYPPSARQHPYYGSGMQSARNPLPGLGQYHISRSHPHDDHDDHYGHSYRQAKKSRPNSPNSTAPSSPTFSHNSLSPTPDHTPLATPAHSPRLRPYSGIELPPFRNLSLQHTPALAPLEPQPGGLAPPPQPASRSNGISLTDIISRPDGAQRKLPVPKVAVHDLLCSSDGFPASGRSSSSNSLSGVELYDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GWT8</accession>
    <name>A0AAJ0GWT8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_183741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723381.1">
        <property type="nucleotide sequence ID" value="XM_062862346.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87881175"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MDR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Alcohol dehydrogenase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
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        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
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        <property type="entry name" value="ER"/>
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        <property type="entry name" value="GroES-like_sf"/>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF3">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G13270)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="12"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3307601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
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</entry>
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            <taxon>Chaetomium</taxon>
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            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3307856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723636.1">
        <property type="nucleotide sequence ID" value="XM_062871403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GX94"/>
    <dbReference type="GeneID" id="87890232"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3307856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="134" mass="14385" checksum="8723BE1D609522EE" modified="2024-07-24" version="1">MPGWYISGIRISAVPMLTAGCSAGLRLWSLVPNPSVFPLGPGMLPVAAYGPGFGVLAEESDLYRCSIFAGYRLEKGSPPLRSSELVGLANNYRFPADDCTFVGDAILRMRLTLSSIPAAEKESVNIERSSWCIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ0GXC6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_86545</name>
    </gene>
    <organism evidence="3 4">
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3307842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723622.1">
        <property type="nucleotide sequence ID" value="XM_062871400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GXC6"/>
    <dbReference type="GeneID" id="87890229"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="182"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="72"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="123"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="421"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="462"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="506"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3307842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="585" mass="63616" checksum="1DF04AEFB2319DA6" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GXC8</accession>
    <name>A0AAJ0GXC8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Essential protein Yae1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_392809</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LTO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3307912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723692.1">
        <property type="nucleotide sequence ID" value="XM_062864661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GXC8"/>
    <dbReference type="GeneID" id="87883490"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019191">
        <property type="entry name" value="Essential_protein_Yae1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052436">
        <property type="entry name" value="LTO1_adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28532">
        <property type="entry name" value="GEO13458P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28532:SF1">
        <property type="entry name" value="ORAL CANCER OVEREXPRESSED 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09811">
        <property type="entry name" value="Yae1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Essential protein Yae1 N-terminal" evidence="3">
        <location>
            <begin position="38"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="80"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="189"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3307912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="230" mass="24166" checksum="35EB500F73ED95D4" modified="2024-07-24" version="1">MATTTTSSPPPASTTPPSAATDPFDTLLTLEDQFYTEGYSQGLADGEVAGRTEGRQLGLERGFQKFLESGRLQGRAIVWANRLPSSKPTARPKLPGSVDQQRTGPLASPGSSAEAGDAELEDGGRATSEGVVELPPLPDNARLEKHITTLYALVESETLSTENTDEAVNDFDDRLRRAHGRAKVIERMVGEHGVGGETRKGTGSDTGSDALGQAHDPGAGPSEADVLNDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GXJ0</accession>
    <name>A0AAJ0GXJ0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ZZ-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_92681</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3307988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723768.1">
        <property type="nucleotide sequence ID" value="XM_062871463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GXJ0"/>
    <dbReference type="GeneID" id="87890292"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14947">
        <property type="entry name" value="NBR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02249">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02340">
        <property type="entry name" value="ZZ_NBR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02341">
        <property type="entry name" value="ZZ_ZZZ3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032350">
        <property type="entry name" value="Nbr1_FW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041981">
        <property type="entry name" value="ZZZ3_ZZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20930">
        <property type="entry name" value="OVARIAN CARCINOMA ANTIGEN CA125-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20930:SF0">
        <property type="entry name" value="PROTEIN ILRUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16158">
        <property type="entry name" value="N_BRCA1_IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="6">
        <location>
            <begin position="453"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="97"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="512"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="783"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="140"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="803"/>
            <end position="826"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3307988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="849" mass="94096" checksum="15D106B73A5B005B" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GXV4</accession>
    <name>A0AAJ0GXV4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SIS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_87485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3307875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723655.1">
        <property type="nucleotide sequence ID" value="XM_062871412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GXV4"/>
    <dbReference type="GeneID" id="87890241"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05014">
        <property type="entry name" value="SIS_Kpsf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035474">
        <property type="entry name" value="SIS_Kpsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38418">
        <property type="entry name" value="SUGAR ISOMERASE, KPSF/GUTQ (AFU_ORTHOLOGUE AFUA_6G08860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38418:SF2">
        <property type="entry name" value="SUGAR ISOMERASE, KPSF_GUTQ (AFU_ORTHOLOGUE AFUA_6G08860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="81"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3307875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="418" mass="44859" checksum="8C026508D0158DB7" modified="2024-07-24" version="1">MVQQCTQRFPPSPITPAESDSSLAIESLNLQTDITACDKKLAVEGRVSRAVHVLATETSALQNLTQLYASDRFARDEFNRAIETLTRRQASGGKLVLIGVGKSGHIAKKLVATFNSLAIQAVFLHPTEALHGDLGQISQRDTLLLITFSGKTPELLTLLPHLDRSLPLILITSHTCPETCELVRHRPDTILLPAPVHEEETTSFGVPAPTTSTTVALAVGDALAIVASHEMHSCVASVFARNHPGGAIGAALRGTKPREDVRSVMVCLEDISSLQHHTRGNPTGLDVLRAGYASPSGWVKLVPDEDGHSGSVSGRETGGVIAPRRIRRMDAEDMSRPLDELKKWLVAPRSGFIPVAADTSVQRAAEWIRGLRTATTTIAGEESEDHEGGAYGDEAIVAVMERGECIGLLEVGRLLEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GXW3</accession>
    <name>A0AAJ0GXW3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_391055</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3307750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723530.1">
        <property type="nucleotide sequence ID" value="XM_062864566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GXW3"/>
    <dbReference type="GeneID" id="87883395"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="20"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="60"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3307750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="467" mass="49041" checksum="06E988983BC99D87" modified="2024-07-24" version="1">MPPIASTGCADGVALSLRLSCDRCRAQKLKCSVPAGSQACQRCKRAKAPCVFGRRTPCKRRRRKKGCGDGDGDGGAGSTSPQQIPQQQVCSPAQQWSVTTPAGLATPPSPVALMSGPRVSGFTLDRELDAPTMAFVEPLAGLPGTMSEVDAGFFVDGPATWNCLSPGLQRLPPDTSGRGSSSTDTVGYERGWLQSGWPLGESAMLEFGQSDLALWSQQPEVTPINVNVTSTAHSLLAATGASDGRRKTGNNSAAAVAGQGLIQLVSEIQHQLRQLEEGPWHTDSASSLDDYPVGTVLALAKQFSALAGSILGCMGREQQQQTANDDATPTVLLVMCGYMWLVRIYAVVLGHFQRHLDHMPANQPDNAAAPCIPSASSPHALRLGELKCADATLGLQQIHTAVCMLLDALHDIESHLGCAGAVGRDMAVALLLKSGKSPEDSDASSSGGLLARKATAVKELLRRKMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GYE8</accession>
    <name>A0AAJ0GYE8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_508884</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724194.1">
        <property type="nucleotide sequence ID" value="XM_062867753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GYE8"/>
    <dbReference type="GeneID" id="87886582"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF13">
        <property type="entry name" value="DUF1996 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042500773" description="DUF1996 domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1996" evidence="2">
        <location>
            <begin position="32"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3308414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="340" mass="37707" checksum="0B58A4825FC7FBC1" modified="2024-07-24" version="1">MHLNSLTALALVAPASALLRFGCSQLVVERLDPLVTPGLNPSPHLHQIIGGNAFNVTMDPSSGDIAERATCTTCQFSEDFSNYWTAVLFFKARNGSYHRVPQIPNVGFDGQSGGMTVYYMQDGLANYEQASKVTAFKTGFRMLVGEASYRSKEQANRFRQITYTCLKDPGTRFPETMDFPKQPCPAGIMANVRFPTCWDGKNLDSPDHMSHMSYPETGTFENGGPCPASHPVRVPQLMYETVWDTRQFNSKDLWPEDGSQPFVWSMDDSTGFGSHGDYMFGWKGDSLQRAMDSPCYVNCPTLKTQSISAMNQCSVPKVVDENYDGWLKALPMGSLEGMKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GYN7</accession>
    <name>A0AAJ0GYN7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">20S-pre-rRNA D-site endonuclease NOB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0T15DRAFT_109767</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for the synthesis of 40S ribosome subunits. Has a role in processing 20S pre-rRNA into the mature 18S rRNA, where it is required for cleavage at the 3' end of the mature 18S rRNA (D-site). Accompanies the 20S pre-rRNA from the nucleus to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
            <location evidence="7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the NOB1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724312.1">
        <property type="nucleotide sequence ID" value="XM_062861487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GYN7"/>
    <dbReference type="GeneID" id="87880316"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09876">
        <property type="entry name" value="PIN_Nob1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000020">
        <property type="entry name" value="20S-pre-rRNA D-site endonuclease NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.10">
        <property type="entry name" value="Nin one binding (NOB1), Zn-ribbon-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039907">
        <property type="entry name" value="NOB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017117">
        <property type="entry name" value="Nob1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036283">
        <property type="entry name" value="NOB1_Zf-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014881">
        <property type="entry name" value="NOB1_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033411">
        <property type="entry name" value="Ribonuclease_PIN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12814">
        <property type="entry name" value="RNA-BINDING PROTEIN NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12814:SF2">
        <property type="entry name" value="RNA-BINDING PROTEIN NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17146">
        <property type="entry name" value="PIN_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08772">
        <property type="entry name" value="Zn_ribbon_NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037125">
        <property type="entry name" value="D-site_20S_pre-rRNA_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144206">
        <property type="entry name" value="NOB1 zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Ribonuclease PIN" evidence="11">
        <location>
            <begin position="52"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Nin one binding (NOB1) Zn-ribbon-like" evidence="10">
        <location>
            <begin position="320"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="152"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="444"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="168"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="192"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="227"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR037125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037125-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3308532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="471" mass="51118" checksum="7015EE61CB305FB5" modified="2024-07-24" version="1">MEQPATKPPAPAQPEGPHPAPAMPDNRNSTESVPTLASSSQTTSPPKPVHSLVIDANAIIKNDPTLSTLLAQAEELYTIPAVISEIRDEATRSRFQTTLSPFLKLRNPRPESVQFVTAFARKTGDLQVLSKPDLHLLALTYDLELERNGGDWRLRREPNQKGVNGKPPGKEEPSADGSRETETEGNFVPDPSATNPNVTEGQDSSAPEALEEVTPPVEEAPGGSIADQLSSLDLNGSAAQGTSSSIEEAGASAEEEDDDGGGEWITPSNIKKYQARENALVAPQPVQLVLQAALITADMAMRNVALRMNLNLLDSGFSRITFLKTWVLRCHGCFKVCKDTSKQFCPGCGQPTLTRVSCSTDAAGNFTLHLKKNFQYNNRGNVYSIPKPTHGSASGKGHNVKGGGKNGWGRELIFAEDQKEYQKKVEEDRRTKYRDIMDQDYLPSILTGSRHSGSGKVKIGAGRDINAKRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GZ21</accession>
    <name>A0AAJ0GZ21_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_525176</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724539.1">
        <property type="nucleotide sequence ID" value="XM_062868828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GZ21"/>
    <dbReference type="GeneID" id="87887657"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="42"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3308759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="1">CBS 333.67</strain>
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    <reference evidence="7" key="1">
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                <person name="Kuo A."/>
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                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
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                <person name="Chen C."/>
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                <person name="Ament-Velasquez S.L."/>
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                <person name="Powell A.J."/>
                <person name="Barry K."/>
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                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
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    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3309188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724968.1">
        <property type="nucleotide sequence ID" value="XM_062865402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GZT5"/>
    <dbReference type="GeneID" id="87884231"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031464">
        <property type="term" value="C:Cul4A-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000109">
        <property type="term" value="C:nucleotide-excision repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042238">
        <property type="entry name" value="Rad28/ERCC8/Ckn1/ATCSA-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46202">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46202:SF1">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="71"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="146"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="238"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="305"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="37"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3309188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="508" mass="53544" checksum="CB08DD9CD03B17DC" modified="2024-07-24" version="1">MNSLLLDRSLGNLGPNAFARIQTTKLLSSFSPAPRFRFDDGERAAGQPSSSSASSQAQVPSHGGDTARASVWAHQAGVSALALERFDGRILISGGSDATIKIWDLEQCPNPWQSHAYHPVAVIPRARTDPSAPGPGPGPSPRPSSTQGHRFGVTGLSFYPFDSAAFLSCSYDQTLKLWSTERASLSGSFDLGAKAYTHATSPIASHLLVACGTQHPAVRLVDLRSAAAVQSLVSPGQIGSSAGATLAVAWSPAHEHVLASGAVDGAVRIWDVRKANALVDLLDQEDIVGLPPTDPQTTRHPRLSAKAHDGPVNGLTWTDDGAYLVSASYDRRVRVWDAATGANTLADFGPTIRNGQLGTLTMFVSPTGLTPPGSERLFFPNETEILVMDLHEGSMVTRLRSIGPVLASVGTQGRGERAVRNRVTSIVWRGSGGGGGGSGVVMGGSNFPGAIYSGHLDGQIRAWVPQLEGAEDEVDDNMSQDADVVGARKRKALDDAFRSLMGKRTTFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H039</accession>
    <name>A0AAJ0H039_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein bL17m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_491579</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the bacterial ribosomal protein bL17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3309045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724825.1">
        <property type="nucleotide sequence ID" value="XM_062866794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H039"/>
    <dbReference type="GeneID" id="87885623"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1030.10:FF:000005">
        <property type="entry name" value="Probable 50S ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.10">
        <property type="entry name" value="Ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01368">
        <property type="entry name" value="Ribosomal_bL17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000456">
        <property type="entry name" value="Ribosomal_bL17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047859">
        <property type="entry name" value="Ribosomal_bL17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036373">
        <property type="entry name" value="Ribosomal_bL17_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00059">
        <property type="entry name" value="L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL17M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413">
        <property type="entry name" value="RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01196">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64263">
        <property type="entry name" value="Prokaryotic ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01167">
        <property type="entry name" value="RIBOSOMAL_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8 9" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3309045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="184" mass="21009" checksum="5F83579E877B16DC" modified="2024-07-24" version="1">MAGGHMKYRQLSRDSAHRQALLRNLVTSLIKNESIHTTWPKAKEAQRLAEKLITHAKKNDEIARRKAQGILFTPHELMPKLFGEIRERYLNRPGGYTRVLRTEPKDKYDQAPSAILELVDGPKDMRFAMTAAAVARDRALGKGHTDLTRKNIAKVTRYRKEGRDEFEEMVDKIQTLGLAESSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H130</accession>
    <name>A0AAJ0H130_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_488243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725300.1">
        <property type="nucleotide sequence ID" value="XM_062866490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H130"/>
    <dbReference type="GeneID" id="87885319"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3309520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="368" mass="38961" checksum="0647561FC7F0045D" modified="2024-07-24" version="1">MSPAQTRRPALATSFSTHNIFCRPIIPPPAPVVYVNGWDGVGKGTVSECLTLLLGRDKSLLIDVRSVGWDSVEEGRRGSTPRTNASPQKQHDQHPHFLLTPEHPRYSSFETDYGVNSIASPSLCQSPSSPSSTNQSASRPTSLCSSSSSLFTTTTTTTTTNTTTATKATIISTTTTTTPEWTTPCSSENLTRLLSHPANRYRIAVLPTCAPDTPGGRATLRTFEAAASRAGRLFVPVALTCSPATHAQRICGRSAGGLAADSAAGTTSGSGASRMMRLHLHRRGIGTGPGMGMGMGVGWTNGQGLATSMSTRALTVDTSSVTPFETALQIVEFVRALQAELEAELCSMGESTNKMPTNSLGKVEREKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H1D6</accession>
    <name>A0AAJ0H1D6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">DNA replication complex GINS protein SLD5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0T15DRAFT_386130</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The GINS complex plays an essential role in the initiation of DNA replication. Has a role in chromosome segregation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the GINS complex which is a heterotetramer of SLD5, PSF1, PSF2 and PSF3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the GINS4/SLD5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725828.1">
        <property type="nucleotide sequence ID" value="XM_062864309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H1D6"/>
    <dbReference type="GeneID" id="87883138"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11711">
        <property type="entry name" value="GINS_A_Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21692">
        <property type="entry name" value="GINS_B_Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1030:FF:000006">
        <property type="entry name" value="DNA replication complex GINS protein SLD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008591">
        <property type="entry name" value="GINS_Sld5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031633">
        <property type="entry name" value="SLD5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038749">
        <property type="entry name" value="Sld5_GINS_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21206:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN SLD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21206">
        <property type="entry name" value="SLD5 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16922">
        <property type="entry name" value="SLD5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007764">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="5 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GINS subunit" evidence="10">
        <location>
            <begin position="61"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="DNA replication complex GINS protein SLD5 C-terminal" evidence="11">
        <location>
            <begin position="167"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR007764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3310048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="221" mass="25298" checksum="0A45E0B428457B74" modified="2024-07-24" version="1">MDIDDILRDVDPTFHIIPQEKSDLQELTRAWIAERSAPELLPWPANGLFERINSSIKRQIEKVEEMTGDMDPKTNFALIVIQTELERYRYLVRSYLRARIAKIDRHTLHYLSTDELRARLSEMELAYATRHQALLHNHYLSSFLSSFPPNLQNLNDTSVGLNMIDAPDLESAVFIRLLKNAVVKGRGVDADDVFDARESDIVILRWADAKPLVEAGSAELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H1K3</accession>
    <name>A0AAJ0H1K3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-hexosaminidase</fullName>
            <ecNumber evidence="7">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0T15DRAFT_26563</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="Glyco_hydro_20_cat"/>
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        <property type="entry name" value="Hex-like_dom2"/>
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    <dbReference type="InterPro" id="IPR029019">
        <property type="entry name" value="HEX_eukaryotic_N"/>
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    </dbReference>
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        <property type="entry name" value="BETA-HEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glycohydro_20b2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001093">
        <property type="entry name" value="B-hxosamndse_ab_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
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        <location>
            <begin position="1"/>
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    <feature type="chain" id="PRO_5042533384" description="Beta-hexosaminidase" evidence="9">
        <location>
            <begin position="22"/>
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        <location>
            <begin position="22"/>
            <end position="164"/>
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    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="10">
        <location>
            <begin position="189"/>
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    <feature type="active site" description="Proton donor" evidence="8">
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DUF3074 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38117">
        <property type="entry name" value="NACHT AND WD40 DOMAIN PROTEIN"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        </location>
    </feature>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF23155"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3310687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
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</entry>
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    <name>A0AAJ0H304_9PEZI</name>
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        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Bonometti L."/>
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                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
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                <person name="Kuo A."/>
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                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
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                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726335.1">
        <property type="nucleotide sequence ID" value="XM_062865530.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87884359"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055589">
        <property type="entry name" value="DUF7165"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23749">
        <property type="entry name" value="DUF7165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="45"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="601"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="755"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="988"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1122"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="656"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="682"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="710"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="755"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="801"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="949"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="988"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1132"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1218"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1234"/>
            <end position="1248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3310555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1308" mass="140564" checksum="F7B90762451A3ECD" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H384</accession>
    <name>A0AAJ0H384_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA replication licensing factor MCM7</fullName>
            <ecNumber evidence="12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">MCM7</name>
        <name evidence="15" type="ORF">B0T15DRAFT_45563</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="12"/>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H384"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097373">
        <property type="term" value="C:MCM core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17758">
        <property type="entry name" value="MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000004">
        <property type="entry name" value="DNA replication licensing factor MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000288">
        <property type="entry name" value="DNA replication licensing factor MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008050">
        <property type="entry name" value="MCM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF26">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24901">
        <property type="entry name" value="WHD_MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01663">
        <property type="entry name" value="MCMPROTEIN7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="14">
        <location>
            <begin position="393"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="747"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="753"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3310675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="831" mass="92274" checksum="AABD97CED9DCF1B0" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H3I1</accession>
    <name>A0AAJ0H3I1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cortical protein marker for cell polarity-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_63640</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062871143.1"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:plasma membrane of growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="BUD SITE SELECTION PROTEIN RAX2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BUD SITE SELECTION PROTEIN RAX2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rax2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Galactose oxidase, central domain"/>
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    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
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        <location>
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            <end position="1243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1174"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="domain" description="Rax2-like second" evidence="5">
        <location>
            <begin position="237"/>
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        <location>
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        <location>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF20843"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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            <authorList>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
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                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
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                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="EMBL" id="JAUDZG010000001">
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
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            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3311141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="321" mass="34244" checksum="41A931B11CC7DEBD" modified="2024-07-24" version="1">MGQHLLLLDFDGTITQHDTLHSLVSLAIAASRPRASKHDNDDRSSALTALWEEIVRDYVAAHARHLAGYSPPAEERTTLELEVAFLESLKSVEAASAARVSRAGFFRGLSGDGLEELGRRAVTLGTATHGGSNGGGNGGGEDGKGNGEKGAVKVREGLAEFVERMGGEEGMWDLAVVSVNWSGRFIKGVVEGSCRAGDRIRRIVANGISWPHGDIQGPDDLGGKPLATAGDKLRAMRSLREGLKEQKVVYFGDSTTDLPCLIEANLGVIMADDVESKLLKTLRRVGFEAPHVGEAGPGSSLVWARDFHEVLRSGVMERILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H3R6</accession>
    <name>A0AAJ0H3R6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
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    <organism evidence="10 11">
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        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
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                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
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                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062871207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H3R6"/>
    <dbReference type="GeneID" id="87890036"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cysteine Rich Protein"/>
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    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rho_GTPase_activation_prot"/>
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    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24215">
        <property type="entry name" value="RHO-GTPASE-ACTIVATING PROTEIN LRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24215:SF10">
        <property type="entry name" value="RHO-GTPASE-ACTIVATING PROTEIN LRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="8">
        <location>
            <begin position="92"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="8">
        <location>
            <begin position="156"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="8">
        <location>
            <begin position="463"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="9">
        <location>
            <begin position="818"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="559"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="612"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="689"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1067"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="629"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="639"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1071"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1088"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1117"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1165"/>
            <end position="1177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3311274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1177" mass="131095" checksum="C10FEBF275EE0172" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H3Y0</accession>
    <name>A0AAJ0H3Y0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">fumarate hydratase</fullName>
            <ecNumber evidence="2">4.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_72449</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reversible stereospecific interconversion of fumarate to L-malate. In mitochondrion, catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH. In cytoplasm and nucleus, involved in DNA repair in response to DNA damage: following DNA double-strand breaks (DSBs), translocates from the cytosol to the nucleus and promotes DNA repair by catalyzing the dehydration of L-malate to fumarate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="2"/>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727143.1">
        <property type="nucleotide sequence ID" value="XM_062871250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H3Y0"/>
    <dbReference type="GeneID" id="87890079"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006106">
        <property type="term" value="P:fumarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01362">
        <property type="entry name" value="Fumarase_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000002">
        <property type="entry name" value="Fumarate hydratase class II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.10:FF:000001">
        <property type="entry name" value="Fumarate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.200.10:FF:000001">
        <property type="entry name" value="Fumarate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00743">
        <property type="entry name" value="FumaraseC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005677">
        <property type="entry name" value="Fum_hydII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018951">
        <property type="entry name" value="Fumarase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00979">
        <property type="entry name" value="fumC_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444">
        <property type="entry name" value="ASPARTATEAMMONIA/ARGININOSUCCINATE/ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444:SF1">
        <property type="entry name" value="FUMARATE HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10415">
        <property type="entry name" value="FumaraseC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarate lyase N-terminal" evidence="5">
        <location>
            <begin position="80"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarase C C-terminal" evidence="6">
        <location>
            <begin position="479"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00056821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3311363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="538" mass="58307" checksum="E72DA11C5E701600" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H471</accession>
    <name>A0AAJ0H471_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_77695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727266.1">
        <property type="nucleotide sequence ID" value="XM_062871307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H471"/>
    <dbReference type="GeneID" id="87890136"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3311486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="161" mass="18494" checksum="BDA6AE3F360C1C36" modified="2024-07-24" version="1">MCSHPSQSCHTRVADECNWKCRHQYHTSCKGSVVSSLSRRRTWLLTVQSSLFVFAGCWRGSRRPRFMLYVASHPLEDWSPVTCGSVLHQPEVYILLSNKGRARRAMKKHRSASHLSHAQSCRGIWTVRPRILIGNQAFCMYMASSTCIRQCDRCGTAHIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H498</accession>
    <name>A0AAJ0H498_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">NUC185 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0T15DRAFT_79933</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727352.1">
        <property type="nucleotide sequence ID" value="XM_062871330.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87890159"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055087">
        <property type="term" value="C:Ski complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070478">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000354">
        <property type="entry name" value="ATP-dependent RNA helicase SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000987">
        <property type="entry name" value="DEAD/DEAH box RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.30:FF:000001">
        <property type="entry name" value="Ski2 ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1500.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025696">
        <property type="entry name" value="Beta-barrel_MTR4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048392">
        <property type="entry name" value="MTR4-like_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016438">
        <property type="entry name" value="SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040801">
        <property type="entry name" value="Ski2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21408">
        <property type="entry name" value="MTR4-like_stalk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="MTR4_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17911">
        <property type="entry name" value="Ski2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005198">
        <property type="entry name" value="Antiviral_helicase_SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="327"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="612"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="214"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="530"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="248"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="549"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="566"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3311572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1289" mass="144077" checksum="BDEA4516F4E26743" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H4C8</accession>
    <name>A0AAJ0H4C8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nucleoporin complex subunit 54-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_522049</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727397.1">
        <property type="nucleotide sequence ID" value="XM_062868600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H4C8"/>
    <dbReference type="GeneID" id="87887429"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044613">
        <property type="term" value="C:nuclear pore central transport channel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006607">
        <property type="term" value="P:NLS-bearing protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036228">
        <property type="term" value="P:protein localization to nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.3600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.490">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024864">
        <property type="entry name" value="Nup54/Nup57/Nup44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025712">
        <property type="entry name" value="Nup54_alpha-helical_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13000">
        <property type="entry name" value="NUCLEOPORIN P54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13000:SF0">
        <property type="entry name" value="NUCLEOPORIN P54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13874">
        <property type="entry name" value="Nup54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18570">
        <property type="entry name" value="Nup54_57_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup54 alpha-helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="308"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="27"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="56"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="308"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3311617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="331" mass="37376" checksum="E6B24B7598A5995D" modified="2024-07-24" version="1">MFSLNRPAGQSVFGGGGTSMFGQSSNQQQLQQQQLQQQQQQQQQQPAQALGQQQGTPNPQLAGSLWQPGSLSSYQKPIPDQIKLITEKWDPSNPNCAFKTYLYNKVDEHTVPLYGPGPNEDPKEWEEALRQKPAPNYIPVLCAGFPSIIARLTLQRRVIVEFNNKLHAINASLDAILSRHDLEHTVRAFNARRRHAELSKRCLMLASRVQVLRNKGYALSGDEDALKQRLQKIDKSIQDPALSARMEELWSRLIILRGYADNLKDEINKPGFAESDGLGEEIEAKAKKILEDYDKQLQHLKKQVEEARKDFEDWEKQHNPAPAPKATAAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LYG6</accession>
    <name>A0AAJ0LYG6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL46</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_303219</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL46 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718152.1">
        <property type="nucleotide sequence ID" value="XM_062863836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LYG6"/>
    <dbReference type="GeneID" id="87882665"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04661">
        <property type="entry name" value="NUDIX_MRP_L46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000018">
        <property type="entry name" value="39S ribosomal protein L46, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040008">
        <property type="entry name" value="Ribosomal_mL46"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021757">
        <property type="entry name" value="Ribosomal_mL46_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033650">
        <property type="entry name" value="Ribosomal_mL46_NUDIX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13124">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L46, MITOCHONDRIAL PRECURSOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13124:SF12">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11788">
        <property type="entry name" value="MRP-L46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Large ribosomal subunit protein mL46 N-terminal" evidence="9">
        <location>
            <begin position="95"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="59"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3302372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="373" mass="41653" checksum="6F39E22B86DD0441" modified="2024-07-24" version="1">MMSAPGRGSALLRSSSRVCAQCARTTPRRTTTAPSPRQPLPVLPLPLVSGRYYAAEAASASASSSPTAPAPPPPVTTSSSETETESATATDPLRYKIKSSLILTRPPLLTREQTPFESAFYLYQKRLNERLTAPFCSKFYFKQDTAADLDWRIKLRERHGVPAKDIGRYNPRGRTAWNDEVLVGSKTSDPQEVVDRLLADAEVRVSEDGEPIAPEERVPVERPMPRRTEADEKNDVRRLDRKLDRTLYLVVRKGEGEDAVWEFPGAIVPTQETLHETAARALAEAAGVNMNTWIVGRVPVAHHIVKPVFREDGKVAERGLKVFFLKGRIMAGQADLSGNKHGLTNFKWLTHEELKEVLPNDYYHSVRGMFELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LYJ2</accession>
    <name>A0AAJ0LYJ2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cleavage and polyadenylation specificity factor subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_404215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer (via N- and C-terminus); binds RNA as homodimer. Component of the cleavage factor Im (CFIm) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Nudix hydrolase family. CPSF5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718170.1">
        <property type="nucleotide sequence ID" value="XM_062865243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LYJ2"/>
    <dbReference type="GeneID" id="87884072"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18871">
        <property type="entry name" value="NUDIX_Cfim25_Nudt21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000005">
        <property type="entry name" value="Cleavage and polyadenylation specificity factor subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016706">
        <property type="entry name" value="Cleav_polyA_spec_factor_su5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13047">
        <property type="entry name" value="PRE-MRNA CLEAVAGE FACTOR IM, 25KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13869">
        <property type="entry name" value="NUDIX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017888">
        <property type="entry name" value="CPSF-25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR017888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3302390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="265" mass="29881" checksum="CBD505A9A9B9A5D2" modified="2024-07-24" version="1">MSTITPTALQSSQPPIIPLPFNANQPETIRLYPLSNYTFGVKETQPEEDPSVLARLKRLEEHYQAHGMRRTCEGILVCHEHNHPHILMLQIANAFFKLPGDYLRPEDEEIEGFKARLDERLAPVGSLGEGNKAGDWQVGDCLAQWWRPNFETFMYPFVPAHITRPKECKKLYFIQLPHSKVLSVPKNMKLLAVPLFELYENTQRYGPQLSAIPHLLSRYNFEFVDENGDVVAATPGAGAGDGYVPRTKVLAGGDDVDMKTENGTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LYP6</accession>
    <name>A0AAJ0LYP6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_403367</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718392.1">
        <property type="nucleotide sequence ID" value="XM_062865201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LYP6"/>
    <dbReference type="GeneID" id="87884030"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057683">
        <property type="entry name" value="DUF7923"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057654">
        <property type="entry name" value="Znf-CCCH_tandem"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37543">
        <property type="entry name" value="CCCH ZINC FINGER DNA BINDING PROTEIN (AFU_ORTHOLOGUE AFUA_5G12760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37543:SF1">
        <property type="entry name" value="CCCH ZINC FINGER DNA BINDING PROTEIN (AFU_ORTHOLOGUE AFUA_5G12760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25540">
        <property type="entry name" value="DUF7923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25543">
        <property type="entry name" value="zf-CCCH_tandem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7923" evidence="2">
        <location>
            <begin position="85"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Tandem CCCH zinc finger" evidence="3">
        <location>
            <begin position="430"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="307"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3302612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="494" mass="55062" checksum="DC023039C6F905AE" modified="2024-07-24" version="1">MSRYDGPSEGFDPAQPYIPPYQAWENLAHERNRIERELAMSYMDLLKRYQDKCAECDRERRTAVLWEKEHRMQERELSAIRSAAESSPFAFVVIDGDGAVFREDLIARGEEGGGEAAHELHQRLKAYFHDNPALSNIDIIFVHVVLSVDGLSRALHASGTLPITDYAALTKFGRGFCRAQPFFSFTDVGYGKEQADHKVRKLFEVMERNIQCRCLILGGCHDNGYATFLESFRNNHKICLLETTPPAADFRKLSFKRVSFPSVFRSEPVPSRPAMPPGFAPPPTAGTFYTSSRSSPPLPHGGNGVTSLPSPAPTASPNAVPHASLATTKPESSTSSYATVGRSNAPVTINIASHKKTTASRPYITFNKNDQRVDVPLAKPDPNAVRAFEEKMHANGRNFCNRWYLMKNCKSPNCNFYHGKEPLTASEMLVLRHKTRNLVCSSGHHCTEVSCNLGHHCANPTSCYFGNNCRFAEMHGMDITPTLKVYDDGTREVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LYT5</accession>
    <name>A0AAJ0LYT5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_543576</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718440.1">
        <property type="nucleotide sequence ID" value="XM_062870004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LYT5"/>
    <dbReference type="GeneID" id="87888833"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07106">
        <property type="entry name" value="ALDH_AldA-AAD23400"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044086">
        <property type="entry name" value="LUC3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="8">
        <location>
            <begin position="29"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="22"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3302660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="484" mass="51856" checksum="2D757BB47591E453" modified="2024-07-24" version="1">MATTADPSKLQDWNSFHNVIDNELTTTPKTRQAVNPNTNEPLPSVPVSSLEDVDRAVAAARAAFPSWSSLSQDERAEYLLKFADAFDANQAGFAKLLGEEAGKPPQAAGIELFLTGVQIRGTVKHRLTEEVNEETDEKLVTIRYVPLGVGVGITPWNLPILIGIIKLSSALLAGNTFIWKPSPYTPNTALKVGELAAKIFPKGVVNVLSGDESLGPLLTTHPDVAKVSFTGSVATGKKVMQACAGTLKRLTLELGGNDAAIVYPDVDIAAVVPQLATWAFVHTGQICVAVKRLYVHEDIYDAFLAALSGVVQAALKTGMNDDPTAVLGPIQNTMQYAKLQDMYAQISQQGWKAVPAPDLSAPKPGAGFFLPPTLIDNPPDDARIVTEEQFGPIVPLLKWSDEDDVVRRANATPYGLGGSVWSADRARAERTARRLEAGTVWVNTHFQLGPQAAFGGHKQSGIGVESGLDGLKGWCNPQTVWVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LYY5</accession>
    <name>A0AAJ0LYY5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_314050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718528.1">
        <property type="nucleotide sequence ID" value="XM_062863966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LYY5"/>
    <dbReference type="GeneID" id="87882795"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="401"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="431"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3302748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="466" mass="50676" checksum="C0A5B17C0B8E8D36" modified="2024-07-24" version="1">MLNLTITVPDGSSNHGNPRLLCTPPSWFDYIIFFFSNYFAHAATVITNPGQGRKETIFVILAALLFPGLGIVRAMEAIRRHSSFEFDPLRRALRAGALCMVVRLGSETSQGPNPLTLEEGRRGVLVSTAKESNEKIGPAGVGITATDADIAQVKALTPSRKDSAKKLEERPWWDPAHPVFLPDDAVVHGQYRLPAGYALAFVPLKAARELESPDQASSNTLASSYNFPKMLISLIQAAWAIITLYRARGDQIQEFGYAAFGLTVAPYAFMSLMNIIGSLLNPEYNAIFLVRTPLMDQAESHAEFNGGGFFAAEVLFKAVENPKRPHHPSSAINVPVLTIHAFGPDLDDDKLLIEYGRMNILLDYGVMIEYGAVIVGCIPLAIIGALSGFQPGNSSSLQRGFTLSWVVMGIITAPFFYNLDKAPQGRDVARFYFGRAAIIIYGAAAIGGMAMVGLMIRDFGVCTLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LYY8</accession>
    <name>A0AAJ0LYY8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Oxidoreductase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_504181</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3302881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718661.1">
        <property type="nucleotide sequence ID" value="XM_062867490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LYY8"/>
    <dbReference type="GeneID" id="87886319"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF282">
        <property type="entry name" value="WW DOMAIN-CONTAINING OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3302881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="33740" checksum="3042939651101E46" modified="2024-07-24" version="1">MICNNKSVSFNPAKDIPPLTDKVILVTGGNIGLGKQAVLEYARHQPQLIWLAARSTEKGNAAAAEIRQAVPDAPIRVLELDLASFASVKRTAATVLSTSTRLDILMLNAGIMAQPPGLTADGYELQFGTNHMGHALLTKLLLPLLTQTATSSSSSSSLSADVRVISLSSHGHIYAPKPGINFSLLKTPAEDLGFVGRYSQSKLANVLWARQLARQYPYLTVAAVHPGMVNTQLVENATGTPAFVRMLVRVGRRLFSEVEDGVRNQLWASVAAGVQSGGYYEPVGVPGGESALAKDEGLGKGLWEWTEKELERQGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZH5</accession>
    <name>A0AAJ0LZH5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_540042</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719175.1">
        <property type="nucleotide sequence ID" value="XM_062869769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZH5"/>
    <dbReference type="GeneID" id="87888598"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3303395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="80" mass="8767" checksum="0B19BD17D0120292" modified="2024-07-24" version="1">MHSQTAGARFSTLTLFAAWHSRSAFRVPQHRLTATVKTKPGRVRRGNLGSRNSVCRPADALTEPIAPYLIRLIIPDGLGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZI0</accession>
    <name>A0AAJ0LZI0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_273936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719190.1">
        <property type="nucleotide sequence ID" value="XM_062863492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZI0"/>
    <dbReference type="GeneID" id="87882321"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3303410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="72" mass="7789" checksum="7B44E40D81E359D7" modified="2024-07-24" version="1">MTLTVIVCFSMDPGYGQLGLLITALAMALCCGHDVLGFLEFVVLVRQTTSTKLGNVPVICCHSDLLHQVHLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M062</accession>
    <name>A0AAJ0M062_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mitochondrial resolvase Ydc2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_503449</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719910.1">
        <property type="nucleotide sequence ID" value="XM_062867470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M062"/>
    <dbReference type="GeneID" id="87886299"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000402">
        <property type="term" value="F:crossed form four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004520">
        <property type="term" value="F:DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070336">
        <property type="term" value="F:flap-structured DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000403">
        <property type="term" value="F:Y-form DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16963">
        <property type="entry name" value="CCE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039197">
        <property type="entry name" value="Mrs1/Cce1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015242">
        <property type="entry name" value="Ydc2_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28072">
        <property type="entry name" value="CRUCIFORM CUTTING ENDONUCLEASE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28072:SF1">
        <property type="entry name" value="CRUCIFORM CUTTING ENDONUCLEASE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09159">
        <property type="entry name" value="Ydc2-catalyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="2">
        <location>
            <begin position="13"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Mitochondrial resolvase Ydc2 catalytic" evidence="3">
        <location>
            <begin position="52"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3304130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="372" mass="39498" checksum="2C9BE07BF2322105" modified="2024-07-24" version="1">MTNVPLLKHSAASLQALCASCGLKKSGTKAALVLRLSLAAKHFQPLPPNTRVLSIDLGLKNFAFSLLSPAPASTPAPAPAPPRAPTPSSPLLNISPVHLHAWHRLDLTLPPSSTPDEQGGEAAEKDNEKEEEGGGDGFSPATLSAVTVDLVKSHLLPLQPTHVLIERQRFRTGGAAAIFEWTLRVNTLEAMLHAVFAALRGAAPAGDGLPNGMPLVVDSVLPRRVAGFLFPDGLLPVPVPEPEVAGVGSLTGAGEGKRKGKGKGRGGNGAYQLLKKGKVDVLGAGLKEGQLVVPQTEQAREMVGLFLEGLAARGQRKRGRKSKEEKDAVDEILTKMDDLSDAVLQGAVWLQWQRNLERLVKERPELLETTEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M081</accession>
    <name>A0AAJ0M081_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class I glutamine amidotransferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_485900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719954.1">
        <property type="nucleotide sequence ID" value="XM_062866320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M081"/>
    <dbReference type="GeneID" id="87885149"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01741">
        <property type="entry name" value="GATase1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044992">
        <property type="entry name" value="ChyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695:SF4">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="1">
        <location>
            <begin position="110"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3304174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="316" mass="35413" checksum="F557C50123990F28" modified="2024-07-24" version="1">MKQLNLAKSCRFTYTKIFHLTSTSQTMSPPAARTLISEHPDKVRLLVLETDETHPETQKETGSFGDVLGQLLKKAGDQHEPTLGIETVMQYVVESEGGMTPTLEEIGEDIHAILITGSTWDAHGDDAWIHKLMSLIKDVWTKRPDIRLAGICFGHQLICRVLGSTVRPAPSGEWELGHTPVSLTDLGRRLFNLPNTAEKAIIHVHQMHVDHVVDPPSPEKEKTDLLPEGTKVHVWGTSDHTGVQGVYIHKRLFTTQGHMEFDEKLVKRQLEMRVESGSVSKEDADEAAERADWEHDGLVVAKAVLRFFHGDDDIYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M0E7</accession>
    <name>A0AAJ0M0E7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_399547</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="2"/>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720058.1">
        <property type="nucleotide sequence ID" value="XM_062865016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M0E7"/>
    <dbReference type="GeneID" id="87883845"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000004">
        <property type="entry name" value="probable E3 ubiquitin-protein ligase HERC4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF9">
        <property type="entry name" value="HECT-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="7">
        <location>
            <begin position="842"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="240"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="371"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="563"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="71"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="305"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="438"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="5">
        <location>
            <position position="1158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3304278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1190" mass="132466" checksum="0174A75A60EA9324" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M1A9</accession>
    <name>A0AAJ0M1A9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_531819</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721062.1">
        <property type="nucleotide sequence ID" value="XM_062869279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M1A9"/>
    <dbReference type="GeneID" id="87888108"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051219">
        <property type="entry name" value="Heterochromatin_chromo-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22812">
        <property type="entry name" value="CHROMOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="4">
        <location>
            <begin position="10"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3305282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="61" mass="7348" checksum="40E8AC1D16720FAB" modified="2024-07-24" version="1">MTKKPQEEYFNVKRILNFQVRYLVEWEGYGPQHNSWEPVEHFERCPNLLRDFCKSTGSVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M1J4</accession>
    <name>A0AAJ0M1J4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cdc37 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_202375</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721349.1">
        <property type="nucleotide sequence ID" value="XM_062862587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M1J4"/>
    <dbReference type="GeneID" id="87881416"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.610">
        <property type="entry name" value="Cdc37, Hsp90 binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004918">
        <property type="entry name" value="Cdc37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013873">
        <property type="entry name" value="Cdc37_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013874">
        <property type="entry name" value="Cdc37_Hsp90-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038189">
        <property type="entry name" value="Cdc37_Hsp90-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12800">
        <property type="entry name" value="CDC37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12800:SF4">
        <property type="entry name" value="HSP90 CO-CHAPERONE CDC37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08564">
        <property type="entry name" value="CDC37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08565">
        <property type="entry name" value="CDC37_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01069">
        <property type="entry name" value="CDC37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101391">
        <property type="entry name" value="Hsp90 co-chaperone CDC37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cdc37 C-terminal" evidence="4">
        <location>
            <begin position="91"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3305569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="175" mass="20527" checksum="8051F1CA2B12DA05" modified="2024-07-24" version="1">MLDRNDEKRAWQYVYQALLLEYCYILGRDGVVVFFKCMTTPGHRAQEDFQKDIAKRFYKIRSMARRDSKQKVVDVEQVQLYPVSEDSSIRIRVPPTGSQDEKEKRGREIFEQFSPEMRAALESASLEEVNKVLAEMAVPEAEKMVSFLDERGIRLAVWISKRESSMPQRKRERGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M1K8</accession>
    <name>A0AAJ0M1K8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_200533</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721303.1">
        <property type="nucleotide sequence ID" value="XM_062862566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M1K8"/>
    <dbReference type="GeneID" id="87881395"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="540"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="605"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="540"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="623"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="638"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3305523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="659" mass="68328" checksum="873BEC0812C5FEF3" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="4">Ankyrin repeat-containing domain protein</fullName>
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        <name evidence="4" type="ORF">B0T15DRAFT_534115</name>
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    <organism evidence="4 5">
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Sordariomycetes</taxon>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3306032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721812.1">
        <property type="nucleotide sequence ID" value="XM_062869418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M200"/>
    <dbReference type="GeneID" id="87888247"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00023">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="303"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3306032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="553" mass="62761" checksum="E01B67F2D3297862" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M285</accession>
    <name>A0AAJ0M285_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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    <organism evidence="7 8">
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722160.1">
        <property type="nucleotide sequence ID" value="XM_062870288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M285"/>
    <dbReference type="GeneID" id="87889117"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="196"/>
            <end position="236"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="5">
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        </location>
    </feature>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3306380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="487" mass="54546" checksum="695FDA5A1DBFE256" modified="2024-07-24" version="1">MVANPRLLRSDNNNIFDFGRHYVAFLPMADQVTHLVNHLIASGYDWGRMYAEAVSGRFLATHGTIHERWYNAIVSELVWREEEEFAGLRIGGEDGGSRRASLEIRRKIWPRGRLPVTTPIEVMEREDVAMGDAVDEKSLTGRYPKRQKKFKKTNPPKKDRKEGIGAKIFRLPVLPRWGELEVVVRLRGDRQQPGECGRHSGSPLNTAKSVCNGCKQASYCSRECQVGDWPLHKKVCKDLAGDGVDDKRPSPEHRRILFFPMHSSEPETKCSSSSADDVDLFAKELCQMGSETKTASGPRSDFGCFAMRVEGVVEMGQGRDAQELTTGMKKEIPQQHKSRCSSRRSLVPSRRKDTEASLGPAANGTNGTANLIRNNDNNTQGRAASTLLDNVERLNKHMNSYPEYMGYQAAPGFREASRQRDSDDNLEKFFGSLKRHEVDPGGCDEGTQTASHDESVKGCTGCSLMPIHSTVNLQKTKEERRDLKKHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M2C6</accession>
    <name>A0AAJ0M2C6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_527209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722217.1">
        <property type="nucleotide sequence ID" value="XM_062868959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M2C6"/>
    <dbReference type="GeneID" id="87887788"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46563:SF4">
        <property type="entry name" value="ASPARTYL_ASPARAGINYL BETA-HYDROXYLASE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46563">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="601"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="633"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="720"/>
            <end position="759"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3306437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="782" mass="87800" checksum="B956126D39F6327B" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M2I9</accession>
    <name>A0AAJ0M2I9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="22">Ribosomal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">B0T15DRAFT_483939</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the 60S subunit of the ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="19">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. eL40 is essential for translation of a subset of cellular transcripts, including stress response transcripts, such as DDR2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="18">Part of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RRN7/TAF1B family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the ubiquitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722412.1">
        <property type="nucleotide sequence ID" value="XM_062866194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M2I9"/>
    <dbReference type="GeneID" id="87885023"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070860">
        <property type="term" value="C:RNA polymerase I core factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001164">
        <property type="term" value="F:RNA polymerase I core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000014">
        <property type="entry name" value="Ubiquitin-60S ribosomal L40 fusion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1060.50:FF:000001">
        <property type="entry name" value="ubiquitin-60S ribosomal protein L40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001975">
        <property type="entry name" value="Ribosomal_eL40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038587">
        <property type="entry name" value="Ribosomal_eL40_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048538">
        <property type="entry name" value="Rrn7_cyclin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048540">
        <property type="entry name" value="Rrn7_cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033599">
        <property type="entry name" value="TAF1B/Rrn7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021752">
        <property type="entry name" value="TF_Rrn7_Zf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31576">
        <property type="entry name" value="TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31576:SF2">
        <property type="entry name" value="TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01020">
        <property type="entry name" value="Ribosomal_L40e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20645">
        <property type="entry name" value="Rrn7_cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20644">
        <property type="entry name" value="Rrn7_cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11781">
        <property type="entry name" value="Zn_ribbon_RRN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01377">
        <property type="entry name" value="Ribosomal_L40e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="12 22" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="15" id="KW-0804">Transcription</keyword>
    <keyword evidence="13" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="21">
        <location>
            <begin position="598"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="127"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="20">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="170"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00035124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00045962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAK3306632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="725" mass="82858" checksum="A4EDAEC36EA62FAE" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M2Y5</accession>
    <name>A0AAJ0M2Y5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA mismatch repair protein S5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_528905</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722788.1">
        <property type="nucleotide sequence ID" value="XM_062869066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M2Y5"/>
    <dbReference type="GeneID" id="87887895"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061982">
        <property type="term" value="P:meiosis I cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16926">
        <property type="entry name" value="HATPase_MutL-MLH-PMS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03483">
        <property type="entry name" value="MutL_Trans_MLH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000014">
        <property type="entry name" value="DNA mismatch repair protein Mlh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000033">
        <property type="entry name" value="DNA mismatch repair protein Mlh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032189">
        <property type="entry name" value="Mlh1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF12">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16413">
        <property type="entry name" value="Mlh1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="7">
        <location>
            <begin position="244"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="382"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="567"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="392"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="407"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="573"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3307008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="755" mass="83241" checksum="21923BA96FF00A8B" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M2Z0</accession>
    <name>A0AAJ0M2Z0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MT-A70-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_413851</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MT-A70-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722803.1">
        <property type="nucleotide sequence ID" value="XM_062865431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M2Z0"/>
    <dbReference type="GeneID" id="87884260"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007757">
        <property type="entry name" value="MT-A70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829:SF4">
        <property type="entry name" value="N(6)-ADENINE-SPECIFIC METHYLTRANSFERASE METTL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05063">
        <property type="entry name" value="MT-A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51143">
        <property type="entry name" value="MT_A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="26"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="106"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3307023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="380" mass="41314" checksum="CEE3B4CE9BB27173" modified="2024-07-24" version="1">MTASCILWQNDRKTVVLLDLPRSIEEAQVPSSELSGADGETPKELRRLISAPPPACPFPTPEPRAGGRGQPASSPSAQVAELMTRAAVESALEEINRSYGGPWSLPRISAPPAKHQVSSNAPSSPPSPAIAAETSSTTPDPSLYYLPPNCHPVLGTVSSHTTAFLSLTAPQQFNLIVLDPPWPNRSAKRKRAGPGAYSPASDLTSIRRLLSQIPVASRLAPGGLVAVWVTNAARFCELLTTPQTGVFAEWDVELIGEWTWLKVTTSGEPVVPVESGWRKPWERLLIARKRGDAGAGERGGEGMRRGALEGKVVVAVPDTHSRKPNLRCLFEEILPAPYEALELFARNLTAGWWAWGDDVLLFQRREFWVDRGEQESCDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M3Z8</accession>
    <name>A0AAJ0M3Z8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC1 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_410503</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723975.1">
        <property type="nucleotide sequence ID" value="XM_062865378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M3Z8"/>
    <dbReference type="GeneID" id="87884207"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13970">
        <property type="entry name" value="ABC1_ADCK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034646">
        <property type="entry name" value="ADCK3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051409">
        <property type="entry name" value="Atypical_kinase_ADCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851:SF3">
        <property type="entry name" value="COENZYME Q8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="6">
        <location>
            <begin position="433"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="31"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="211"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="240"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3308195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="788" mass="86021" checksum="D84483F59531DDAB" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M451</accession>
    <name>A0AAJ0M451_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_96149</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723854.1">
        <property type="nucleotide sequence ID" value="XM_062871495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M451"/>
    <dbReference type="GeneID" id="87890324"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3308074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="284" mass="31517" checksum="A873BA154C11F454" modified="2024-07-24" version="1">MQDQYSCTGPDGIRLEIASRQAPVDKVLSKLLAWRLRVCGSAAARSSQASYLSPLSETRSRHGADCNAQVITCLARCWTRDQMDTLSFRSRCPDATGLCFGGNTELGVLVQYKLRSQRYGTLCGLFSATGSSPRTKGLKLSSDQIPTLPGLSVFWCCGKLVSVPMRYFSGSLRCLFLSILRTQSTKKISGRPQYEVNSMPKSIVYSFAESSILLNQTDDFDAYYQGPTPKSRLACATSREAVSNQFLCHQSRTRSTASNRNNCLFNRHTHLTTHHHCGWGDTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M5I8</accession>
    <name>A0AAJ0M5I8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">3-hydroxy-3-methylglutaryl coenzyme A reductase</fullName>
            <shortName evidence="10">HMG-CoA reductase</shortName>
            <ecNumber evidence="10">1.1.1.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0T15DRAFT_389865</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(R)-mevalonate + 2 NADP(+) + CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15989"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.34"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the HMG-CoA reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.34" evidence="10"/>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725666.1">
        <property type="nucleotide sequence ID" value="XM_062864514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M5I8"/>
    <dbReference type="GeneID" id="87883343"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004420">
        <property type="term" value="F:hydroxymethylglutaryl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015936">
        <property type="term" value="P:coenzyme A metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00643">
        <property type="entry name" value="HMG-CoA_reductase_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3270.10:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.420:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.770.10:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.770.10">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl-coenzyme A Reductase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3270.10">
        <property type="entry name" value="HMGR, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.420">
        <property type="entry name" value="Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025583">
        <property type="entry name" value="HMG-CoA_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002202">
        <property type="entry name" value="HMG_CoA_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023074">
        <property type="entry name" value="HMG_CoA_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023076">
        <property type="entry name" value="HMG_CoA_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004554">
        <property type="entry name" value="HMG_CoA_Rdtase_eu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023282">
        <property type="entry name" value="HMG_CoA_Rdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009023">
        <property type="entry name" value="HMG_CoA_Rdtase_NAD(P)-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009029">
        <property type="entry name" value="HMG_CoA_Rdtase_sub-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00533">
        <property type="entry name" value="HMG_CoA_R_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572:SF24">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00368">
        <property type="entry name" value="HMG-CoA_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13323">
        <property type="entry name" value="HPIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00071">
        <property type="entry name" value="HMGCOARDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55035">
        <property type="entry name" value="NAD-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56542">
        <property type="entry name" value="Substrate-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00066">
        <property type="entry name" value="HMG_COA_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00318">
        <property type="entry name" value="HMG_COA_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01192">
        <property type="entry name" value="HMG_COA_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50065">
        <property type="entry name" value="HMG_COA_REDUCTASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0521">NADP</keyword>
    <keyword evidence="7 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="484"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1113"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="12">
        <location>
            <begin position="243"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="669"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1140"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1143"/>
            <end position="1157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3309886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1182" mass="128007" checksum="B59FFD54418EA912" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M5X7</accession>
    <name>A0AAJ0M5X7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hyphal anastamosis-8 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_21707</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725802.1">
        <property type="nucleotide sequence ID" value="XM_062862751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M5X7"/>
    <dbReference type="GeneID" id="87881580"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42069">
        <property type="entry name" value="HYPHAL ANASTAMOSIS-8 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42069:SF1">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="302"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="424"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3310022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="504" mass="54874" checksum="EE46046F65A35327" modified="2024-07-24" version="1">MGLDEKKRPLALNLTPARTMSASSVSTTDSDSTSSSLAKPPRTPRFAEATAVHSPIEPRKLPFSEKSEIAQAQPGDVGFGYIGAGANRESIAVPMTPRSPLKSAMKVPGTPGRALQNPMSPTFLEEQVLEKREKMTEKEQARDLKIKTRVRLAKFALRGVNFSCSLIILAMISASFSIFNATKALPAMSGFPAWAHNTNAWPQKVVLACSCVSLLICIGVFIGYCRGGHRRAEKVGVYYTLFAVGWFIFSMAMWAAAAGILQVSRNNSNNQDIWGWACVENKRSQLFGDKVDYALICRLQDWALICIIIELVVEIISISLYSVIFYRYWSKRKLHKSMDMRDKARSDLYLAQLRTQSAPNTPGFGPKSPAFSQYALSPRFPPSTYKSLGDIEEDNASPFTPGGKGLIIPQSTFTAKQSSFKLQAPPTKANPATPATPKAGYKPPTAADLSPTTTVAPDLAATAVKFNEPAPMAEGEQQYEAVPIPGAYAGQAIKSPPPVRTTFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M6J7</accession>
    <name>A0AAJ0M6J7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cora-like Mg2+ transporter protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_47107</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726510.1">
        <property type="nucleotide sequence ID" value="XM_062865989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M6J7"/>
    <dbReference type="GeneID" id="87884818"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015087">
        <property type="term" value="F:cobalt ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494:SF1">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3310730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="246" mass="28139" checksum="36EE9068E7F00D4E" modified="2024-07-24" version="1">MGQNLLFDDSSFTNARRYFWALQSLRVFDDHISGTVRLLKEMIRSIDEDSHSRSGESENQIQEDLFNEHRAILDELRARIERKRQEIESLNNGLFSASSVAEARFSSEQNGNIRLLTLVTIAYLPLSFVATIYGMNVLPEGTSLGSFFVATAVLSVITFAIVFNLQLLTVFIRRHLFGKALDSMRLDPSPQWRDRAQHLRQEGANKRKSFPASKWLYLGYLFHLVFDRKAAPPSAEKGRRDDSHTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M6M2</accession>
    <name>A0AAJ0M6M2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_519527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726585.1">
        <property type="nucleotide sequence ID" value="XM_062868436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M6M2"/>
    <dbReference type="GeneID" id="87887265"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042553559" description="Secreted protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3310805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="96" mass="10746" checksum="991CB7FE557DF4B9" modified="2024-07-24" version="1">MFHGLGWSWFGVLWYYIEGSRLCPNVYAVCCSSKGCHLSVSLKKSPERGRSSVEQLSPTVKLVPPFRVLGQLLLEQTGIGQLFMQTTQARATTQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GKG0</accession>
    <name>A0AAJ0GKG0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_317101</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family. DCP2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717376.1">
        <property type="nucleotide sequence ID" value="XM_062864009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GKG0"/>
    <dbReference type="GeneID" id="87882838"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140933">
        <property type="term" value="F:5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03672">
        <property type="entry name" value="NUDIX_Dcp2p_Nudt20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1050:FF:000003">
        <property type="entry name" value="Decapping enzyme Dcp2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000003">
        <property type="entry name" value="M7GpppN-mRNA hydrolase isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1050">
        <property type="entry name" value="Dcp2, box A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007722">
        <property type="entry name" value="DCP2_BoxA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036189">
        <property type="entry name" value="DCP2_BoxA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044099">
        <property type="entry name" value="Dcp2_NUDIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23114">
        <property type="entry name" value="M7GPPPN-MRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23114:SF17">
        <property type="entry name" value="M7GPPPN-MRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05026">
        <property type="entry name" value="DCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01125">
        <property type="entry name" value="DCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140586">
        <property type="entry name" value="Dcp2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="10">
        <location>
            <begin position="95"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="344"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="523"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="587"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="700"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="772"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="349"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="393"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="544"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="610"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="635"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="645"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="711"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="823"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="863"/>
            <end position="874"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3301596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="894" mass="98858" checksum="AE93A63E6E6CEC12" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GL00</accession>
    <name>A0AAJ0GL00_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_578106</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717646.1">
        <property type="nucleotide sequence ID" value="XM_062871085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GL00"/>
    <dbReference type="GeneID" id="87889914"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3301866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="198" mass="20882" checksum="8F5FD500AA2EC796" modified="2024-07-24" version="1">MVFPRGQQSLGVVLRTCHEAPRSHLSPVYIVSGIRGILHGRIMAVPSLLPSYPGKEPCRAWTVMLDDPNGGIVNGEWGSVVVDRETNGVYGHIVGRGPLAHAYVVSLAHVLDQLNSCFGGAASTPTLSPPTGFRPRSQDPGDQYPSIAAPGSASVVTRGRNLGLQTTGPPVAPSFTPITIGEAAKLSSMRRLWDAVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GL40</accession>
    <name>A0AAJ0GL40_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_405326</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717683.1">
        <property type="nucleotide sequence ID" value="XM_062865290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GL40"/>
    <dbReference type="GeneID" id="87884119"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF193">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G00940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="328"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="419"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="456"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="533"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="64"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3301903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="568" mass="60558" checksum="D1ED242584AEE2F0" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GL45</accession>
    <name>A0AAJ0GL45_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short chain dehydrogenase reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_442118</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717677.1">
        <property type="nucleotide sequence ID" value="XM_062865938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GL45"/>
    <dbReference type="GeneID" id="87884767"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF80">
        <property type="entry name" value="NAD(P)-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3301897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="307" mass="33120" checksum="955D330C80E8D223" modified="2024-07-24" version="1">MASLSIKESDIPSQAGKTAVITGGASGIGLAAARILVEKGAAVHVLDLNRPAAEEDQHIPGLQFHQCNISVWEELRSAFEEIGHIDYAFANAGVSEETDYFADTLDGEGRLIEPTYRVLDVNVRGAYNVVKLAWSHMRKDKTPGSIVITTSASGYAPEQSLPVYSSGKLALVGLIRALRSVIIQDNITINGVAPAATITSLLPAHLAAPIMAMGLPVSDARFVGLALVHSAVATQNRRVQAYGKEADGDVWKKGERWNGRVILTLGDRYTELEEPTADLRPFWFGRENTQMTRLQQAATDFRPLGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GL73</accession>
    <name>A0AAJ0GL73_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="13">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B0T15DRAFT_541593</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RAD25/XPB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="13"/>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3301979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717759.1">
        <property type="nucleotide sequence ID" value="XM_062869871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GL73"/>
    <dbReference type="GeneID" id="87888700"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000112">
        <property type="term" value="C:nucleotide-excision repair factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18029">
        <property type="entry name" value="DEXHc_XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18789">
        <property type="entry name" value="SF2_C_XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000077">
        <property type="entry name" value="Probable DNA repair helicase RAD25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000117">
        <property type="entry name" value="Putative DNA repair helicase rad25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050615">
        <property type="entry name" value="ATP-dep_DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032438">
        <property type="entry name" value="ERCC3_RAD25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001161">
        <property type="entry name" value="XPB/Ssl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032830">
        <property type="entry name" value="XPB/Ssl2_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00603">
        <property type="entry name" value="rad25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274">
        <property type="entry name" value="RAD25/XP-B DNA REPAIR HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16203">
        <property type="entry name" value="ERCC3_RAD25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13625">
        <property type="entry name" value="Helicase_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00851">
        <property type="entry name" value="XRODRMPGMNTB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="370"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="586"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="764"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="827"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK3301979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="862" mass="96844" checksum="01EE404E17FA880E" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GLD4</accession>
    <name>A0AAJ0GLD4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_290479</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717846.1">
        <property type="nucleotide sequence ID" value="XM_062863705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GLD4"/>
    <dbReference type="GeneID" id="87882534"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3302066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="202" mass="22331" checksum="328BF9276ACF074B" modified="2024-07-24" version="1">MIFQYTCAYCGMVGTYRGDPRVIMIQMPGLVPENLGSSICSRLDGVYVDSFYPATVFLPRSTTTCACNAIGPTSETSQVREAGKGWKQDTCERNTVQFRLLGSGVVFVRLLESCTVHAEPHVAADCTKSVKERCCLLPLKPDVPILEDAFYIPGETRQRWTPSSLCSGRDSGRPCNPDICTPITLVEVLRSYPTKYYSVHKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GMK0</accession>
    <name>A0AAJ0GMK0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_543719</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718492.1">
        <property type="nucleotide sequence ID" value="XM_062870014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GMK0"/>
    <dbReference type="GeneID" id="87888843"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3302712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="66" mass="7198" checksum="A65C5A8B786DF9B1" modified="2024-07-24" version="1">MHRLRRVLQGARILPCFLPCLITREVAEGKTVDFVLAPYLGSESEGGMQLSVPSPMHANLVCFLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GMP2</accession>
    <name>A0AAJ0GMP2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_562820</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718552.1">
        <property type="nucleotide sequence ID" value="XM_062870593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GMP2"/>
    <dbReference type="GeneID" id="87889422"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000554">
        <property type="entry name" value="Ribosomal_eS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047861">
        <property type="entry name" value="Ribosomal_eS7_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11278">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11278:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01251">
        <property type="entry name" value="Ribosomal_S7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00948">
        <property type="entry name" value="RIBOSOMAL_S7E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3302772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="203" mass="22991" checksum="E0F16DEB0F660CD8" modified="2024-07-24" version="1">MSSPSLNKIAANSPSRQNPSELEQAIAGALYDLETNTADLKAALRPLQFVSAREIEVGHGKKAIVIFVPVPSLQGFHRVQQRLTRELEKKFSDRHVLILASRRILPRPKRSSRSRNTLKQKRPRSRTLTAVHDAILTDLVYPVEIVGKRLRTKEDGSKTLKVILDEKERGGVDYRLDTYSEVYRRLTGRGVVFEFPQTTAADY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GN67</accession>
    <name>A0AAJ0GN67_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_538957</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718837.1">
        <property type="nucleotide sequence ID" value="XM_062869710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GN67"/>
    <dbReference type="GeneID" id="87888539"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF80">
        <property type="entry name" value="GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
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            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042532403" description="Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein" evidence="3">
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        </location>
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            <begin position="354"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="141"/>
            <end position="144"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
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            <position position="292"/>
        </location>
        <ligand>
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        </ligand>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3303057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="623" mass="66442" checksum="E6BD298783E6619D" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ0GND9_9PEZI</name>
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            <fullName evidence="2">Macro domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
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                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062870508.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87889337"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Macro_OAADPr_deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106">
        <property type="entry name" value="GANGLIOSIDE INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 2-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="MACRO DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    </dbReference>
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        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="990"/>
            <end position="1174"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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        </location>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="KAK3302925.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
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                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718999.1">
        <property type="nucleotide sequence ID" value="XM_062863424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GNJ2"/>
    <dbReference type="GeneID" id="87882253"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <end position="75"/>
        </location>
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        <location>
            <begin position="118"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3303219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="343" mass="39097" checksum="B87C8B7D50C0F2B7" modified="2024-07-24" version="1">MSDHYETMAKYLYDCGWETIAKRPLRHRDTNPEDTNMETRTFLNYLTVQDAGLPPPSRPTQAKSAVAEKARDPRKVSFAPDTQEPVARSRRYYSASPPPRSSTGSSERVAGPKRYSASPLRRLPGPSRPSSRSISPITSPRTFSSRAFKLSVPWPSQASPVEWYGVVPVLRDQATHAVLSHCAPWSWVSDPVPSAAEEQALWQQIVYRPIDLAAKLWALNRHNAGLRRSLESFATSLHIAANHASAAITSTLMIPPSRWWWWYQDHFEDWVWTMWSVRARLEKLLKALKKALARREEMVRLMDKIKALATELLLLAATAEPEPEPKPKHTLAVYVYYLLRLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GNM4</accession>
    <name>A0AAJ0GNM4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_269267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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        </lineage>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719057.1">
        <property type="nucleotide sequence ID" value="XM_062863442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GNM4"/>
    <dbReference type="GeneID" id="87882271"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22794">
        <property type="entry name" value="THAP DOMAIN PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22794:SF2">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="516"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3303277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="628" mass="66922" checksum="9E7FB83F82A10B19" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GNN3</accession>
    <name>A0AAJ0GNN3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_560268</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719077.1">
        <property type="nucleotide sequence ID" value="XM_062870525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GNN3"/>
    <dbReference type="GeneID" id="87889354"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3303297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="299" mass="33586" checksum="3DF5835894D8E2C7" modified="2024-07-24" version="1">MRYYATNCTYQNERTLALQIPQLLAKIARDPDPNARDASRSYDRIMEEAKVARDVLGVAIKFQEYPLLRNVLNWVDASSVSNETLSLVRLATTSGTLEFGEIKESLLQHFSKRSLQLNVLCLSALWPLKEAPHPEIEALVVNGASIPLTTPRYHQLILAILETYIDRYVGPEPPAEINWTVPGVNCNSYNCTSSDCSELDAFLRSSTQSVARVQIGKKRRQHLHQLLDRARSPCTHTTDRSTYPETLVVTKVVGKGLARNGWEARVKKAREVLEGFGSDLGTSLKEDYDRIMRMVAPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GP84</accession>
    <name>A0AAJ0GP84_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_504591</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719140.1">
        <property type="nucleotide sequence ID" value="XM_062867502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GP84"/>
    <dbReference type="GeneID" id="87886331"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008733">
        <property type="entry name" value="PEX11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652:SF23">
        <property type="entry name" value="MICROBODY (PEROXISOME) PROLIFERATION PROTEIN PEROXIN 11B (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05648">
        <property type="entry name" value="PEX11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="1" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="293"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3303360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="456" mass="50797" checksum="629BC76BF59A3306" modified="2024-07-24" version="1">MTVQVSTFEQFVKFGTDAYGLERLLRLIQALTQLLLSLPALRLLLLHPLLSAPSYSAVAPVVLQALRKRIASIRQAFRIFRFLDSFSSAWSVWSLPPHPDAAGSGFVAARVERWMDFGAKSFTGMYLLLESLTVAESLAVPGLSLWGEQRAAELAMDGQRFWFVGLVCGLLAGVLRLTAKEYVTGGTVADKRSQREVEKGKGRKRRVFRRVVADALDLAVPGQRSNLPEQRRLIFTENEVLHEYDAGVLWRETVFTEHPALPSMQFRVPSCESSTILQLSSLVKHSILSAERNPGRDPSDVEVTDARGKATSPGLSFKSGLNDWSQPNTVVYRWDPPIGQTENTTGLYPLIALEDKGIGIERRYLHIDAIDKVDGWARELDNMLVLSAETMHVTISAEGEPLRWDTDTRRYTIGSFDGGNGHHDRYITPLGSVRHSKRILGSRGHSCADRLFVLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GPL5</accession>
    <name>A0AAJ0GPL5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycoside hydrolase family 55 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_487074</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719521.1">
        <property type="nucleotide sequence ID" value="XM_062866407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GPL5"/>
    <dbReference type="GeneID" id="87885236"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23668">
        <property type="entry name" value="GH55_beta13glucanase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000023">
        <property type="entry name" value="Exo-beta-1,3-glucanase Exg0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039279">
        <property type="entry name" value="QRT3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="RHGA/B-epi-like_pectate_lyase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928:SF2">
        <property type="entry name" value="PECTATE LYASE SUPERFAMILY PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928">
        <property type="entry name" value="POLYGALACTURONASE QRT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pect-lyase_RHGA_epim"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042566671" evidence="2">
        <location>
            <begin position="22"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="3">
        <location>
            <begin position="128"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="3">
        <location>
            <begin position="487"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3303741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="860" mass="90008" checksum="44AB33653C8D0C45" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GPM8</accession>
    <name>A0AAJ0GPM8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_487166</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719643.1">
        <property type="nucleotide sequence ID" value="XM_062866417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GPM8"/>
    <dbReference type="GeneID" id="87885246"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006418">
        <property type="term" value="P:tRNA aminoacylation for protein translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3303863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="467" mass="51239" checksum="7026F0F188AAB5E3" modified="2024-07-24" version="1">MKLKTTLIGLLRNLETDKGSPTPDSNTREVLSAIDGLLRKLTPGTALYAAFHDGQVHDPLGAGSYAFKDDFVGPILLGLVNDETSGSGPTSSNNDQHAALAMPTRPIIFHAGAQPNNSPHCGTLIVFFFTFAVARAVRDRLQASMSGGLAPPVSVEMTLVDTAPVNSEGIEVEGIQYQRSYRDVPNALGTRIADYQEVFALLSAWSGIPVHISFQRDFFSQAHMPSLVSYLVANHKQLGQQLAPTYGTLAVRAACPVPGCHLAEKHGRRNQYTYQTTRPGKVADPKPSEAAAAAITFHCPRHGPHTINTSSADELARLEANAPTRNLLRSMSHLLDTDRHHVRVTGADYAGMYQETFLYRPLAAWSAATDHARGRTPHILYAPLVVDWSGAKLSKSLYVRDGGYAAMRLFRSDGLCSYVRLKEQVGKEGLRRLWDEVVRWVADPRKLFRCWSVEYLQRIAIQGEVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GPU1</accession>
    <name>A0AAJ0GPU1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_223857</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3303909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719689.1">
        <property type="nucleotide sequence ID" value="XM_062862846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GPU1"/>
    <dbReference type="GeneID" id="87881675"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF14">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="201"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="687"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="688"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3303909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="713" mass="80259" checksum="A71C8DF397F09127" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQ31</accession>
    <name>A0AAJ0GQ31_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">CDP-alcohol phosphatidyltransferase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_227460</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719812.1">
        <property type="nucleotide sequence ID" value="XM_062862899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQ31"/>
    <dbReference type="GeneID" id="87881728"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003881">
        <property type="term" value="F:CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000011">
        <property type="entry name" value="Cdp-diacylglycerol-inositol 3-phosphatidyltransferase pis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362:SF4">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--INOSITOL 3-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3304032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="311" mass="34403" checksum="3F5909A84FA5F62C" modified="2024-07-24" version="1">MSGTKNRRQGTAGASPEDKEIARSNGSAQVADDTIADGEPRENIFLLWPNIIGYSRIVLAVASLYYMPLHPRTCSILYSVSCLLDALDGYAARYFEQSTRFGAVLDMVTDRCTTACLLVFLSSAFPRWAILFQGLISLDLASHYMHMYATLAMGGAENSHKNIDKSRSRILSLYYTNKTVLFIMCLFNETFFIALYLLSFSSPFLSPSLLQTVPDHAAREAIQHHGAQVNSSLLKQIFTNPYSAGALELARANKMDSFWPWVVAGVSFPVMALKQIINVVQLVKASKWLAEGDLRARKAAGLPRRSKGKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQA5</accession>
    <name>A0AAJ0GQA5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_535554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719881.1">
        <property type="nucleotide sequence ID" value="XM_062869500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQA5"/>
    <dbReference type="GeneID" id="87888329"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17316">
        <property type="entry name" value="Perilipin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3304101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="203" mass="22075" checksum="95D5749E282B1C3A" modified="2024-07-24" version="1">MSSAKTTSVPDGDVPQLNTLRHLLTYPAVQDSVRVFKSNPLGRMSIQLSNSAYNMTAPMLSMLNKPYGYVEPYVKRVDELGDQTLSKVEEKFPVVKKPSPELLNEAKQVVYGPVKHVTEVYNGKYQQTSGGYAVASGKAAVMTAAVITGEGLVYAARSLLKWTESLHLGETIKAKVDNLEAAVARQEQNAESQNGRQPKSASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQA6</accession>
    <name>A0AAJ0GQA6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Alpha-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Maltase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_231906</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="3"/>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719949.1">
        <property type="nucleotide sequence ID" value="XM_062862958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQA6"/>
    <dbReference type="GeneID" id="87881787"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033934">
        <property type="term" value="F:glucan 1,4-alpha-maltotriohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004574">
        <property type="term" value="F:oligo-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000025">
        <property type="term" value="P:maltose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11333">
        <property type="entry name" value="AmyAc_SI_OligoGlu_DGase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000064">
        <property type="entry name" value="Oligo-1,6-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000087">
        <property type="entry name" value="Oligo-1,6-glucosidase IMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.400.10:FF:000003">
        <property type="entry name" value="Probable alpha-glucosidase (Maltase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="entry name" value="Oligo-1,6-glucosidase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF222">
        <property type="entry name" value="MALTASE MALT (AFU_ORTHOLOGUE AFUA_8G07070)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0462">Maltose metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="9">
        <location>
            <begin position="26"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00073730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3304169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="606" mass="69505" checksum="04B422393C8E2F27" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQD4</accession>
    <name>A0AAJ0GQD4_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_494678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719977.1">
        <property type="nucleotide sequence ID" value="XM_062867027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQD4"/>
    <dbReference type="GeneID" id="87885856"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="351"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="489"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="509"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="565"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3304197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="607" mass="64554" checksum="4548DE08224BAE3D" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQF5</accession>
    <name>A0AAJ0GQF5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Histidine kinase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_512426</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="8">J domain-containing protein</fullName>
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    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
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    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719920.1">
        <property type="nucleotide sequence ID" value="XM_062870997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQN7"/>
    <dbReference type="GeneID" id="87889826"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000069">
        <property type="entry name" value="ER associated DnaJ chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051100">
        <property type="entry name" value="DnaJ_subfamily_B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015399">
        <property type="entry name" value="DUF1977_DnaJ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908:SF3">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09320">
        <property type="entry name" value="DUF1977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="52"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3304140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="359" mass="39636" checksum="6BDD256B03329B5F" modified="2024-07-24" version="1">MPADASASGAATSQNDGSARSRREHNQGNQERKYTAEQKAAVLRIRRCQPTAFYEILELQRTCTDAEVKKAYRKLSLLTHPDKNGHEHADEAFKMVARAFSVLGDKEKRDKYDRFGTDPDSRFASAQAQAQAQNPFAGFAGRRAGGGGGGMWEEEISPEEMFARFFGGGGLGGGFGGPFAGFDGGPQFVFNFGGPGIRVHQFGGARPRARPRNPGQEEPASMWSTIIGLLPILLLVVWPILSSIFSGMTSSTPSTPSMVFDEPHPPLYTMERTMPNLNVRYYLNPADVQSYSPSKLYSLDKKAEVVLVQQLRIKCESEMAHKQQLQNAAQGWFYPDPEKMEVANAYPMPACQRLNSMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQT2</accession>
    <name>A0AAJ0GQT2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_536492</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720218.1">
        <property type="nucleotide sequence ID" value="XM_062869552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQT2"/>
    <dbReference type="GeneID" id="87888381"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1430.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.960.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.960.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000351">
        <property type="entry name" value="Ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.960.10">
        <property type="entry name" value="Ribosomal protein L3, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045077">
        <property type="entry name" value="L3_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044892">
        <property type="entry name" value="Ribosomal_L3_dom_3_arc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_uL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_uL3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3304438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="392" mass="44210" checksum="E366346E33A9CC71" modified="2024-07-24" version="1">MSHRKYEAPRHGSLAFLPRKRAARHRGKVKSFPKDDPKKPVHLTAAMGYKAGMTTIVRDLERPGAKAHKKEIVEAVTIIDTPPMIVVGLVGYIETPRGLRSLTTVWAEHLSDEVKRRFYKNWYKSKKKAFTKYAKKHSENNGASITRELERIKKYCTVVRVLAHTQIRKTPLKQKKAHLMEIQINGGSVADKVEFGHGLFEKPVSIDTIFEKDEMIDVIAVTKGHGFVGVTARWGTKKLPRKTHKGLRKVACIGAWHPSHVQWTVARAGQMGYHHRTSVNHKIYRIGKGDADDNAATDVDVTKKKITPMGGFVRYGEVNNDFVMVKGSVPGVKKRVMTLRKSMFTHTSRKALEKVELKWIDTSSEFGHGAFQTPAEKKQYQGTLKKDLVASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQV9</accession>
    <name>A0AAJ0GQV9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_243329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720272.1">
        <property type="nucleotide sequence ID" value="XM_062863095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQV9"/>
    <dbReference type="GeneID" id="87881924"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3304492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="149" mass="16896" checksum="498D88869BC7C515" modified="2024-07-24" version="1">MVRAPGLIRTTDLLGCLRSWFKVRFTQDNTDTGQAWLAWLTSIEPTVASYIGQVCKSPESSHTIYVVFCRRDFGSLAPLFLSGEPLCHRDAKTPSGKSTSRSCEAMPRAFYLTTVCCYLPFMSPTMWFWVFAPLELKLGTVVKIWRWVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQX6</accession>
    <name>A0AAJ0GQX6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Snf7 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_234104</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720035.1">
        <property type="nucleotide sequence ID" value="XM_062862991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQX6"/>
    <dbReference type="GeneID" id="87881820"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF5">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="164"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="170"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3304255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="210" mass="23522" checksum="FB93D4C52F37CB14" modified="2024-07-24" version="1">MGTSSSRITAQDQAILDLKTQRDKLHQYQRRITHLTDKETAIARQMLAKGDKPRALLALRRKKYQESLLAKTDAQLEQLEKLTSSVEFALIQKDVLFGLQQGTKVLKEIQREMGGIENVEKLMGETAEAIAYQREIGEILAGSMSNQDEEEVEDELAALEAEVTRRESGQRIQLPNVPDTQLPAQKARDEARPELAEQGAQPARKAMLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GRG8</accession>
    <name>A0AAJ0GRG8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase C1A papain C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_576164</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720574.1">
        <property type="nucleotide sequence ID" value="XM_062871014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GRG8"/>
    <dbReference type="GeneID" id="87889843"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3304794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="390" mass="43143" checksum="FB9857D8826DA188" modified="2024-07-24" version="1">MSCGTWEAGPSSWGGRIPEILPTALKVDPKASPIDQVKQAYDDIYSRIQQTSQFTRNKAIAFIELHKSQRNATLEQQLGSSNAQKIAATAAIHGLVVSANSMIDTLNAMYLMDVSPEDFAAVSRFLQYADAHSLQDAAEAAANLPGLSDANEDPDDAGDLSLLIRKDTGCSSRSAVKCLLDQDADSGLFHDVDTTPNPCAPTDLEKATFQEKLISLANTTPQTTKGILQDSQGPPNMRIAFARIFDEAAKARIENPTKMTDSDWQMIYDQPAVVLLEQNLRDGFPFIFTTQLVLGARFNKHEIGQDAVWVKPPIENVITRGRHTMLAVGFDPGRRLFLVQNSWGPKWPLSYSGSDERLRGRFWMPYEWFEAAVDGKPLTYDFWVPCTIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GRK8</accession>
    <name>A0AAJ0GRK8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L10e/L16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_568383</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720385.1">
        <property type="nucleotide sequence ID" value="XM_062870761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GRK8"/>
    <dbReference type="GeneID" id="87889590"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.10:FF:000003">
        <property type="entry name" value="54S ribosomal protein L16, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="entry name" value="Ribosomal protein L10e/L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047873">
        <property type="entry name" value="Ribosomal_uL16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000114">
        <property type="entry name" value="Ribosomal_uL16_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020798">
        <property type="entry name" value="Ribosomal_uL16_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_uL16_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_uL16_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01164">
        <property type="entry name" value="rplP_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220:SF13">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL16M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00060">
        <property type="entry name" value="RIBOSOMALL16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="Ribosomal protein L16p/L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00701">
        <property type="entry name" value="RIBOSOMAL_L16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3304605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="261" mass="28336" checksum="3DD16640E68E3BFF" modified="2024-07-24" version="1">MRPTASSALLGAFQALRISPATPVRASLPSTAASRCSPPTTSASASQHVRLFSVTAVRAGTWLEPDLPRKKKMMKGRPRVPTGGSTKGTTVVWGDYGLRMCDHHRRVSAAQLKLAEDTIKQRLRGEKYRLYKRVACNVGVFVSGNEMRMGKGKGSFDHWAARIAVNQIVFEIRGLLHEQVIRDAFRLAGNKLPGTASLAAVVGQDADWYIGQWEFVRKGDPPVVGITKLDGITLEDLKKPWKKLPAPEAPASTPSSSAPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GRP3</accession>
    <name>A0AAJ0GRP3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_399125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720692.1">
        <property type="nucleotide sequence ID" value="XM_062864990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GRP3"/>
    <dbReference type="GeneID" id="87883819"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3304912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="214" mass="22981" checksum="56B286C58F1873A5" modified="2024-07-24" version="1" fragment="single">AYRTYTIDHCHRWEDLAADMDDQPRARAAKRLMPALCLGTTHKIDEEDDLVACSVEHSDAKVQTQVLAAYVEPAAGGSPRMGNGYDEDSDCDDGLGNGIASGRTTLDRPLIVRNVSSADINDANNTTVLGREGEDYTTTEASPAAKTSYADDNISNAVDIAMSEKAGEDNATTKTSSTAKASDMDNTIMFQQEGAGYRQSDNCPDCSRDKPLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GRP8</accession>
    <name>A0AAJ0GRP8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_255456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720679.1">
        <property type="nucleotide sequence ID" value="XM_062863240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GRP8"/>
    <dbReference type="GeneID" id="87882069"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3304899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="240" mass="26990" checksum="CC4684EDCBD3E754" modified="2024-07-24" version="1">MDEPALQIKPIHDELEEIYDIALELEATVEKMRKLQTRSRAFQIVHALVLGQRDESEVRDVVGRLRDAQDTLGYRISVAHVGSTTGVARWSTESRRELRAYGKTSRAKKIFRSSKSTTTLQRGPNKRTQSKSGKAWVCRRHGSRTTRRGMEVGRGTSSPLEAKQFAVPAELQATCVRCASCSRPGRLRHEYTRAQHTPPSLLRDRTRPCSGPIGGGCLEWVWSIMLAFSVRIVSRCLACK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GS62</accession>
    <name>A0AAJ0GS62_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_554948</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720877.1">
        <property type="nucleotide sequence ID" value="XM_062870373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GS62"/>
    <dbReference type="GeneID" id="87889202"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022198">
        <property type="entry name" value="DUF3723"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12520">
        <property type="entry name" value="DUF3723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3305097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="393" mass="45497" checksum="91DB81CDFB8DF19A" modified="2024-07-24" version="1">MQRSNCIERERRVAVERSTKYWGTVSVDIDILEFPNEEEEENIDKLVELFQNDYRGLNPRYRIPAKIDKHQLDAALALSGLTFQKLKEAPDRIRGYPELKFPAGFRLKCCQGLHRSRAAARILPPGERCWSIDLYDSDIDPDLDAELREGYSAEKEPNDGVVYYRIRTYQGHHGPANPFLESRWWALLKYNSKQKKKNLKGILDDPYYKAAFDIQMDILALGDGMELGVIHKMFTMRCDELALKYLGHIKKVWKDEICEKNPETMQKIDRSTVKALQHTAPGCCKKDREDLWKKLQSGEIFSAFAEQERQIIWDRVLSASTTRLIPSLFTFFEDLNYLEGPLQSLKRLVPLSRKETISAALLRAYKDINQEPDQVKIQESESIMTFVPGTKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GSK1</accession>
    <name>A0AAJ0GSK1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AFG1-like ATPase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_398325</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AFG1 ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721117.1">
        <property type="nucleotide sequence ID" value="XM_062864947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GSK1"/>
    <dbReference type="GeneID" id="87883776"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005654">
        <property type="entry name" value="ATPase_AFG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169:SF2">
        <property type="entry name" value="AFG1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169">
        <property type="entry name" value="ATPASE N2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03969">
        <property type="entry name" value="AFG1_ATPase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="529"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="531"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3305337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="655" mass="73563" checksum="20166130AB0D2B63" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GSM9</accession>
    <name>A0AAJ0GSM9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Arylsulfatase</fullName>
            <shortName evidence="5">AS</shortName>
            <ecNumber evidence="5">3.1.6.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Aryl-sulfate sulphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_396058</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an aryl sulfate + H2O = a phenol + sulfate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17261"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:33853"/>
            <dbReference type="ChEBI" id="CHEBI:140317"/>
            <dbReference type="EC" id="3.1.6.1"/>
        </reaction>
    </comment>
    <comment type="PTM">
        <text evidence="6">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.1" evidence="5"/>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721188.1">
        <property type="nucleotide sequence ID" value="XM_062864811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GSM9"/>
    <dbReference type="GeneID" id="87883640"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005539">
        <property type="term" value="F:glycosaminoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008449">
        <property type="term" value="F:N-acetylglucosamine-6-sulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018958">
        <property type="term" value="P:phenol-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16147">
        <property type="entry name" value="G6S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000051">
        <property type="entry name" value="Arylsulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012083">
        <property type="entry name" value="Arylsulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-SULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108:SF8">
        <property type="entry name" value="SD21168P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000972">
        <property type="entry name" value="Arylsulf_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042562280" description="Arylsulfatase" evidence="8">
        <location>
            <begin position="20"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="9">
        <location>
            <begin position="47"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="19"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="6">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000972-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3305408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="615" mass="67896" checksum="0079B740AFDC36A5" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GSY0</accession>
    <name>A0AAJ0GSY0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_493717</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721343.1">
        <property type="nucleotide sequence ID" value="XM_062866964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GSY0"/>
    <dbReference type="GeneID" id="87885793"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18621">
        <property type="entry name" value="GH32_XdINV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.560">
        <property type="entry name" value="Exo-inulinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013189">
        <property type="entry name" value="Glyco_hydro_32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800">
        <property type="entry name" value="EXOINULINASE INUD (AFU_ORTHOLOGUE AFUA_5G00480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800:SF3">
        <property type="entry name" value="GLYCOSYL HYDROLASE FAMILY 32 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08244">
        <property type="entry name" value="Glyco_hydro_32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 32 N-terminal" evidence="6">
        <location>
            <begin position="89"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 C-terminal" evidence="7">
        <location>
            <begin position="479"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="449"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="449"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3305563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="656" mass="71785" checksum="F6BCD30672F32442" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GT65</accession>
    <name>A0AAJ0GT65_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_397913</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721461.1">
        <property type="nucleotide sequence ID" value="XM_062864929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GT65"/>
    <dbReference type="GeneID" id="87883758"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000191">
        <property type="entry name" value="mRNA splicing factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032847">
        <property type="entry name" value="PRPF17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43979">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43979:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="246"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="290"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="377"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="512"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="153"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3305681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="545" mass="60881" checksum="A574A462E4251C2D" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GTB6</accession>
    <name>A0AAJ0GTB6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ran guanine nucleotide release factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_207065</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MOG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721494.1">
        <property type="nucleotide sequence ID" value="XM_062862630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GTB6"/>
    <dbReference type="GeneID" id="87881459"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.10">
        <property type="entry name" value="Mog1/PsbP, alpha/beta/alpha sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007681">
        <property type="entry name" value="Mog1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016123">
        <property type="entry name" value="Mog1/PsbP_a/b/a-sand"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15837">
        <property type="entry name" value="RAN GUANINE NUCLEOTIDE RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15837:SF0">
        <property type="entry name" value="RAN GUANINE NUCLEOTIDE RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04603">
        <property type="entry name" value="Mog1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55724">
        <property type="entry name" value="Mog1p/PsbP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3305714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="204" mass="22894" checksum="6B91D3394D64FEBD" modified="2024-07-24" version="1">MPRFKETPLFGGALVCDLPDNFADVSMIRKVPDNQEVYLDKDGFTSIIFDITERVDAPGDDPLERDGRALTIHLEDLVGEDADTVKVWNTTETQFSHLDESIPAYTLIATQTPHKPADDEEGSASRRSSAPDFTALILTLVRLEREQTDILITINVPHIKGEYDEEEVDLALGKQGELIGDAVEYAAKIWATFEVRDWKLFNEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GTE7</accession>
    <name>A0AAJ0GTE7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF155 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_533449</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721581.1">
        <property type="nucleotide sequence ID" value="XM_062869365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GTE7"/>
    <dbReference type="GeneID" id="87888194"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070131">
        <property type="term" value="P:positive regulation of mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051624">
        <property type="entry name" value="RMD1/Sad1-interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255:SF1">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF155" evidence="3">
        <location>
            <begin position="178"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="53"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="10"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3305801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="449" mass="49564" checksum="FC73DE413838F44F" modified="2024-07-24" version="1">MRPLLPNIGPAARTVSASVRSPASSRIPRQRCVHPTPTACLPRRRNFFTSNVLMQQDGGEPSRTPTAEKRAEGDKSSSTAKQLSSAQKKRKPTLKNSLHRVAIVAQKGVPGKQSPPAPETPAGPDGSSTISAVCIAESFDMDKVEGILRSHGFSLDPDGTGFEAHEVVHARGLNNADIFVFPSGTVVTWALPSDVVNTLATKHLLPAAEIPFVEEKEVEDLEFLVDPEQEESRVSGAVVVLGTRREVDAGDRLDTTLAKIAFSSGLARSTKLAVLESSLTRYLESTRHIPDRLSQGLRAPLSRELILQKAGELLNLRSQLNHYNDLTDALPDIFWDSEEKLETYYSKIGKALDVGVRIKTLNDKMTYAQEVVNVAQGVLDISEKMSSEQHSTRLEWIIIVLIAIEVVFELRRLYMERYDAFQDDLLVELRALRADMRKSGDRPDVVAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GTM6</accession>
    <name>A0AAJ0GTM6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS general substrate transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_556542</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721733.1">
        <property type="nucleotide sequence ID" value="XM_062870422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GTM6"/>
    <dbReference type="GeneID" id="87889251"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF187">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="390"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="457"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="487"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="522"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="597"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="129"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="629"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="106"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="645"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3305953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="667" mass="70853" checksum="A8673AA2840B45FB" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GTT8</accession>
    <name>A0AAJ0GTT8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_485284</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721510.1">
        <property type="nucleotide sequence ID" value="XM_062866284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GTT8"/>
    <dbReference type="GeneID" id="87885113"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050375">
        <property type="entry name" value="MFS_TsgA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43702">
        <property type="entry name" value="L-FUCOSE-PROTON SYMPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43702:SF5">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3305730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="398" mass="42709" checksum="9DEAFE237FCA467F" modified="2024-07-24" version="1">MGLWSRKITVSDDTLTSAAHLTLRQSMIPNLLVTVLFFLWGFAYGLLDVLNSHFQSQLHISASMAAGLSSAYFGAYFICPPTISGWILRRSGFRVTFMTGLAVFAVGCLLFWPSGVKRSFGGFCGSMFVVGAGLATLETAADPFLLNLAQAVQGVGSFVAPLLASRVFFASTVDNNEGLKSVQWVYLGVACFDVLLIVLFVLAPMPEITDADMHAQEGEIGQYDPGPFRKQTNLFLAVWSQFCYVGAQVAVANYFINFCEEAGRDRATSSDLLAVGQGLYAFNRFVAGGLLTLPLFKPRYMLAAYLGLCFVFVIAAMTTSGSASIAMLTLVLCFESCCFATIFTLGLRGLGRHTKMGGSLLVAAISGGMVFPPMTGAVLDARNAHIAMAIPMMGYILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GU46</accession>
    <name>A0AAJ0GU46_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein S10 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_220242</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3306186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721966.1">
        <property type="nucleotide sequence ID" value="XM_062862805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GU46"/>
    <dbReference type="GeneID" id="87881634"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.600:FF:000002">
        <property type="entry name" value="40S ribosomal protein S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="entry name" value="Ribosomal protein S10 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_uS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_uS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018268">
        <property type="entry name" value="Ribosomal_uS10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_uS10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_uS10_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005729">
        <property type="entry name" value="Ribosomal_uS10_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01046">
        <property type="entry name" value="uS10_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="Ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00361">
        <property type="entry name" value="RIBOSOMAL_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS10" evidence="4">
        <location>
            <begin position="20"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3306186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="116" mass="13194" checksum="23956E7AC953679E" modified="2024-07-24" version="1">MSYNKPEKDFGEAPKVHKIRITLTSRKVQALEKVCQELIERAKNKDLRVKGPVRLPTKILKITTRKTPCGEGSKTWDSYEMRIHKRLIDLTAPTEIVKQIIINIEAGVEVEVTIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GU52</accession>
    <name>A0AAJ0GU52_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Vitamin B6 photo-protection and homoeostasis-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_221972</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RUS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3306221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722001.1">
        <property type="nucleotide sequence ID" value="XM_062862820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GU52"/>
    <dbReference type="GeneID" id="87881649"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006968">
        <property type="entry name" value="RUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054549">
        <property type="entry name" value="UVB_sens_RUS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12770:SF31">
        <property type="entry name" value="RUS FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12770">
        <property type="entry name" value="RUS1 FAMILY PROTEIN C16ORF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04884">
        <property type="entry name" value="UVB_sens_prot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein root UVB sensitive/RUS" evidence="6">
        <location>
            <begin position="35"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3306221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="448" mass="49710" checksum="948A8469222FCFF0" modified="2024-07-24" version="1">MSRSFYDIDPAGEVLCTYTDSGETTKLKSEKTEVPLPKAILYAFLPAGYPHTVTDDYLAYQTYDSLQAFASSITSLLANRAVLEGLGVGDSSSSPTGALILKITGDTISRVATILFAHRMGQAIEPECKFYRFLADIFNDSAQFLDLLTPALPYLPKLGVIVSAGVLRSLCGVAANASKASLSAHFALTGNLAELNAKEASQETVVSLLGMLAGSLVVRLVEDKQVVWMLMMFLAGVHLTMNYRAVRSVKMRSLSRQRATIVFREWLEHGTVLTPAQVAARESILRKGRGNLESKSGEYTGFCDFATYGELKGWNPRGYHRYDFETKAYFMAIWHHGGYFYMRIALKEGTRNPLSAWFDAVNHAYHFDSALKDGLESHYENEMPLGYVSEEQKESIFAALTAAGWDLETNALETRLPIRVRVGDGWKGLHLSEKDPIRHHSHQVPKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GUJ6</accession>
    <name>A0AAJ0GUJ6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_534749</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3306235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722015.1">
        <property type="nucleotide sequence ID" value="XM_062869456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GUJ6"/>
    <dbReference type="GeneID" id="87888285"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF4">
        <property type="entry name" value="HYPOTHETICAL CONSERVED PROTEIN (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="31"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3306235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="101" mass="11209" checksum="02F8FEA1D8AB3B07" modified="2024-07-24" version="1">MERSSDAAGDAPRKDRQRAAKPKAKSGWSNCNTIKQTRIKCDEQRPACANCLRSKKICSGYPPFTRSPSPPEAVPAAMVDEWRYALSHDGDPESSSFLHEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GV48</accession>
    <name>A0AAJ0GV48_9PEZI</name>
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        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_139377</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722200.1">
        <property type="nucleotide sequence ID" value="XM_062861864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GV48"/>
    <dbReference type="GeneID" id="87880693"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="15"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="52"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="535"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="539"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="636"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3306420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="688" mass="74594" checksum="D5EC177877582077" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GVK9</accession>
    <name>A0AAJ0GVK9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SEC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_528646</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722718.1">
        <property type="nucleotide sequence ID" value="XM_062869052.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87887881"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056604">
        <property type="entry name" value="GBF1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF388">
        <property type="entry name" value="GOLGI-SPECIFIC BREFELDIN A-RESISTANCE GUANINE NUCLEOTIDE EXCHANGE FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23325">
        <property type="entry name" value="TPR_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="2">
        <location>
            <begin position="651"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="523"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1328"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1566"/>
            <end position="1607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="349"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1568"/>
            <end position="1578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3306938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1607" mass="177177" checksum="7E98D58D9B82748E" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GVS7</accession>
    <name>A0AAJ0GVS7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="25">Pyrimidine-specific carbamoyl phosphate synthase-aspartate carbamoyl transferase</fullName>
            <ecNumber evidence="6">2.1.3.2</ecNumber>
            <ecNumber evidence="5">3.5.1.2</ecNumber>
            <ecNumber evidence="19">6.3.4.16</ecNumber>
            <ecNumber evidence="4">6.3.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="29" type="ORF">B0T15DRAFT_413945</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="29">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="29" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="29">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="24">Multifunctional protein that encodes the first 2 enzymatic activities of the de novo pyrimidine pathway: carbamoylphosphate synthetase (CPSase; EC 6.3.5.5) and aspartate transcarbamylase (ATCase; EC 2.1.3.2). The CPSase-function is accomplished in 2 steps, by a glutamine-dependent amidotransferase activity (GATase) that binds and cleaves glutamine to produce ammonia, followed by an ammonium-dependent carbamoyl phosphate synthetase, which reacts with the ammonia, hydrogencarbonate and ATP to form carbamoyl phosphate. The endogenously produced carbamoyl phosphate is sequestered and channeled to the ATCase active site. ATCase then catalyzes the formation of carbamoyl-L-aspartate from L-aspartate and carbamoyl phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>carbamoyl phosphate + L-aspartate = N-carbamoyl-L-aspartate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20013"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>hydrogencarbonate + NH4(+) + 2 ATP = carbamoyl phosphate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18029"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="18">In the 2nd section; belongs to the CarB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">In the 3rd section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">In the C-terminal section; belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="17">In the N-terminal section; belongs to the CarA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="29">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.2" evidence="6"/>
    <dbReference type="EC" id="3.5.1.2" evidence="5"/>
    <dbReference type="EC" id="6.3.4.16" evidence="19"/>
    <dbReference type="EC" id="6.3.5.5" evidence="4"/>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722856.1">
        <property type="nucleotide sequence ID" value="XM_062865432.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87884261"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005951">
        <property type="term" value="C:carbamoyl-phosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004070">
        <property type="term" value="F:aspartate carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004087">
        <property type="term" value="F:carbamoyl-phosphate synthase (ammonia) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
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        <property type="entry name" value="CAD protein-like isoform X1"/>
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        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
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        <property type="entry name" value="ATP-grasp"/>
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        <property type="entry name" value="ATP_grasp_subdomain_1"/>
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        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
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        <property type="entry name" value="CarbamoylP_synth_ssu"/>
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        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
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        <property type="entry name" value="Class_I_gatase-like"/>
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        <property type="entry name" value="CPAse_ATP-bd"/>
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        <property type="entry name" value="CPSase_dom"/>
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        <property type="entry name" value="CPSase_GATase1"/>
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        <property type="entry name" value="CPSase_lsu"/>
    </dbReference>
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        <property type="entry name" value="CPSase_lsu_oligo"/>
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        <property type="entry name" value="CPSase_preATP-grasp"/>
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        <property type="entry name" value="Metal_Hydrolase"/>
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        <property type="entry name" value="MGS-like_dom"/>
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        <property type="entry name" value="MGS-like_dom_sf"/>
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        <property type="entry name" value="asp_carb_tr"/>
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        <property type="entry name" value="CPSaseII_lrg"/>
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        <property type="entry name" value="CPSaseIIsmall"/>
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    </dbReference>
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        <property type="entry name" value="PRK00856.1"/>
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        <property type="entry name" value="PRK05294.1"/>
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        <property type="entry name" value="PRK12815.1"/>
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        <property type="entry name" value="PRK12838.1"/>
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    </dbReference>
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        <property type="entry name" value="CAD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CARBAMOYLTRANSFERASE FAMILY MEMBER"/>
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    </dbReference>
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        <property type="entry name" value="CPSase_L_D1"/>
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        <property type="entry name" value="CPSase_L_D2"/>
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        <property type="entry name" value="CPSase_L_D3"/>
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        <property type="entry name" value="CPSase_sm_chain"/>
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        <property type="entry name" value="GATase"/>
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        <property type="entry name" value="MGS"/>
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        <property type="entry name" value="OTCace"/>
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        <property type="entry name" value="OTCace_N"/>
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        <property type="entry name" value="AOTCASE"/>
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        <property type="entry name" value="ATCASE"/>
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        <property type="entry name" value="CPSGATASE"/>
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        <property type="entry name" value="CPSase_L_D3"/>
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        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="GATASE_TYPE_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 26" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10 26" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-grasp" evidence="27">
        <location>
            <begin position="571"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="27">
        <location>
            <begin position="1108"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="28">
        <location>
            <begin position="1365"/>
            <end position="1514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012738"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00043968"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00043979"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00043984"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00043998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00044063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00058513"/>
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    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00081752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="KAK3307076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="2238" mass="246024" checksum="138A3E6D5102F177" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GVV3</accession>
    <name>A0AAJ0GVV3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_492525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722799.1">
        <property type="nucleotide sequence ID" value="XM_062866863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GVV3"/>
    <dbReference type="GeneID" id="87885692"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3307019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="274" mass="29522" checksum="966DD2A4EFF5FE36" modified="2024-07-24" version="1">MAPAVQQPRAAAAAAAEPAPISAQPPVSDPDAHPVPGVGTPSETLQLLARQQFTVTQTSTQTAAPVQTSTIPAFYGSLNTGPQPGAVAGIVLGSVAGFILLLWLLYVCINGGVGRRGVSSTSDTATTFTEGTASVVTRKSRRHRHRERSRERRRQETVEIRRRHSTSRVRAAGGGGAVVVEEVVRGVSPPPGARVERVVSTEERRRSVSRVRRVPSSEGGTEDEVVVIEEHSPPRARYRSRERRSSGFREVDPDRFAGGDATFVEVRRSASHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2025-04-02" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GVX6</accession>
    <name>A0AAJ0GVX6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_166212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722927.1">
        <property type="nucleotide sequence ID" value="XM_062862165.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87880994"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3307147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1404" mass="154162" checksum="0F6786A0E4F38FE5" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GWV5</accession>
    <name>A0AAJ0GWV5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histone acetyltransferase ESA1</fullName>
            <ecNumber evidence="4">2.3.1.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Histone acetyltransferase esa1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15 24">protein 2-hydroxyisobutyryltransferase ESA1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17 25">protein acetyltransferase ESA1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16 26">protein crotonyltransferase ESA1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="30" type="ORF">B0T15DRAFT_530705</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="30" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="30">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="30" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="30">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac. The NuA4 complex is involved in the DNA damage response and is required for chromosome segregation. The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) through homologous recombination. Recruitment to promoters depends on H3K4me. Also acetylates non-histone proteins. In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA) or (2E)-butenoyl-CoA (crotonyl-CoA), and is able to mediate protein 2-hydroxyisobutyrylation and crotonylation, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>(2E)-butenoyl-CoA + L-lysyl-[protein] = N(6)-(2E)-butenoyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53908"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:13707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:137954"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:53909"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>2-hydroxyisobutanoyl-CoA + L-lysyl-[protein] = N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24180"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:15921"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:131780"/>
            <dbReference type="ChEBI" id="CHEBI:144968"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:24181"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21992"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:21993"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:45949"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="30">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="4"/>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723407.1">
        <property type="nucleotide sequence ID" value="XM_062869189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GWV5"/>
    <dbReference type="GeneID" id="87888018"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000022">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.60:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000002">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025995">
        <property type="entry name" value="Tudor-knot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF218">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE ESA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11717">
        <property type="entry name" value="Tudor-knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="11" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="29">
        <location>
            <begin position="212"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="83"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="28">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="28">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="28">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="28">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="28">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="27">
        <location>
            <position position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00045805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00074445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00075313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00076782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00077673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="KAK3307627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="498" mass="57412" checksum="D4266400D6D0A3B8" modified="2024-07-24" version="1">MTSNGTNGGAEVGSGEERRKGKATPDTLKVGCIAIVTKDGHPRRAEILSIKETKSGKQFYCNFDNFNKRLDEWVPVSRIDFDQDVEWPNPDKDKQKDAKNKKSTVSKKSQPPKKAQKRVGKREESVASEGQTPHPWTEFVESQNKADGEDRANASLEVGATPTVGPDEMELDEDETPASAAKKEHLQPFSREQEIEKLRTSGSMTQNPAEISRIRNISKVEFGRHVLFPWYFSPYPEVFSQEDCIYICEFCLSYYGDLKAFTRHRMKCTLQHPPGNEIYRDDFISFFEIDGRRQRTWCRNLCLLSKMFLDHKTLYYDVDPFLFYVMTTRDDRGCHMIGYFSKEKESADGYNVACILTMPQYQRKGYGRLLIQFSYELSKIEGKLGSPEKPLSDLGLLSYRQYWSENIIDLLLGYSEREEKCTIEGIASALAMTTQDVEHTLQALKMQIYHKGEHKIVIPEKLVQQRERSRAKQKRVINPDQIQWKPPVFTAASRTWAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GWY4</accession>
    <name>A0AAJ0GWY4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_183822</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723384.1">
        <property type="nucleotide sequence ID" value="XM_062862350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GWY4"/>
    <dbReference type="GeneID" id="87881179"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3307604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="246" mass="25900" checksum="5D7FDFC1F8D730BA" modified="2024-07-24" version="1">MLSSTSPSSSPPREKRRYAPLKPSPLNPNTYYFDSARHGGSAGRTKPTRRSKLHQPHPARFPQRYAVLLSESPTQRLLRQKALAAWRHHHVSSMPASAASVGRSQRGAHSSVPPAGTYKSSNGPAQERPPHGGARAAEICPDERKDDDDGGEGGVGLLTVNAAGQREGILCISCPDLEREGGEGERVTGAIRKRGRYPGRAVDASGIAVRRVFAVVAVFIGLGLVHGLVTAFGGAAVGGRPPAAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GX07</accession>
    <name>A0AAJ0GX07_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_510922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723454.1">
        <property type="nucleotide sequence ID" value="XM_062867883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GX07"/>
    <dbReference type="GeneID" id="87886712"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="453"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3307674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="588" mass="64971" checksum="EE9EC10C1B87132F" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GX11</accession>
    <name>A0AAJ0GX11_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_484710</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723429.1">
        <property type="nucleotide sequence ID" value="XM_062866237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GX11"/>
    <dbReference type="GeneID" id="87885066"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="51"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3307649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="445" mass="50512" checksum="8A1508C727030C1B" modified="2024-07-24" version="1">MAGRKFVGFCRAPTVTEEVYIAEVDLEDFEEYSSGGYHPTVIGDTFCDGRYELVHKLGFGGYSTIWLAKDKQLQRYVSLKILIANEFSKSTEAKILPRSKFIPRLLDEFSTDSPNGHHVCLEDSSDFMFQVETARSIAAQLIKGLSYLHSQGVCHDLHVRNFLICGTDIDHLDPLDFYRRYRLDMTPVRRVDGTAVGPHAPPYAVYPLHIKTPANSLVNPVIRISDFGTSFVVAEEPNPALHTPDPYRPPEAFFNEPITLAADIWTLRVNLYEILGERCLFETFFWDRDDIIAEIVNTLGLLPKRWWEKWEARGEFFEADGSWRKGGITRIFTPKFRRLHQRMWDMGRGETPKTCQWDVEGGEMRALEELLRGMMAFEPSERLTAEEVHQWPDSNPTIYLALALSTVSDIGPGQNQQPLLPIIAIAITIQLSPSPASSLSTRSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GX21</accession>
    <name>A0AAJ0GX21_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_185263</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723442.1">
        <property type="nucleotide sequence ID" value="XM_062862365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GX21"/>
    <dbReference type="GeneID" id="87881194"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052400">
        <property type="entry name" value="Zn2-C6_fungal_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657:SF14">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="32"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="347"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3307662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="522" mass="57377" checksum="9122596826E11F63" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GX87</accession>
    <name>A0AAJ0GX87_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Fringe-like glycosyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0T15DRAFT_181507</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723310.1">
        <property type="nucleotide sequence ID" value="XM_062862317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GX87"/>
    <dbReference type="GeneID" id="87881146"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10811">
        <property type="entry name" value="FRINGE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="11">
        <location>
            <begin position="297"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3307530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="615" mass="68039" checksum="6211A23DE6A8FF3B" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GY80</accession>
    <name>A0AAJ0GY80_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin-like fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_106512</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAX family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724148.1">
        <property type="nucleotide sequence ID" value="XM_062861433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GY80"/>
    <dbReference type="GeneID" id="87880262"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026928">
        <property type="entry name" value="FAX/IsoI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050931">
        <property type="entry name" value="Mito_Protein_Transport_Metaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289:SF41">
        <property type="entry name" value="FAILED AXON CONNECTIONS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289">
        <property type="entry name" value="METAXIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17172">
        <property type="entry name" value="GST_N_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01180">
        <property type="entry name" value="SUF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01200">
        <property type="entry name" value="SUF1.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin-like fold" evidence="3">
        <location>
            <begin position="28"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3308368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="276" mass="30865" checksum="1D7D3E4233628AEE" modified="2024-07-24" version="1">MSPKPTAATPTLTLFRGFPQHDRYTPSPFINKLETRLRIGGIAYQVGVGSPFTAPRGKMPYIELQDADNVNSSTSPTPPTKLGDTALITRKLVEDGHLEDLNARLTPTQRAADLAVRALLEDKLYFFQGRERWVDNYHTMRDTVLASIPYPLRLVIGLLAYRKHARTLDGQGVLRFSKEEAAAMRLEIWESVNAMLVESRAHAANNKAGNTSGPFWVLGGESPTEADPVVFGFVAAALDCRMAPETEKIVRGFPVVVEYAKRIHDRYFSDFKCWRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GYI3</accession>
    <name>A0AAJ0GYI3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_102521</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724015.1">
        <property type="nucleotide sequence ID" value="XM_062861378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GYI3"/>
    <dbReference type="GeneID" id="87880207"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032157">
        <property type="entry name" value="PAC4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16093">
        <property type="entry name" value="PAC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3308235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="150" mass="16265" checksum="6F101DF96ED0617E" modified="2024-07-24" version="1">MSHTMEAPIQSSFPLPRSLDTRVFLRLTVKPKAIVLFLTTASMEEAGSPSPLGSFVYALPDRYKPSQPLSTPLCTVEPTIEFTTRLAKLLARKTQRPTYVGNSISLASTGLGGTVEEEMEAFQKVVEVTLSQLQPLIGSAQSPSDGVRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GYM4</accession>
    <name>A0AAJ0GYM4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Uracil catabolism protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_508989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724314.1">
        <property type="nucleotide sequence ID" value="XM_062867761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GYM4"/>
    <dbReference type="GeneID" id="87886590"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012469">
        <property type="entry name" value="DUF1688"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31687">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31687:SF3">
        <property type="entry name" value="PROTEIN URG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07958">
        <property type="entry name" value="DUF1688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3308534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="552" mass="60303" checksum="A7CE2759D448FB00" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GZ41</accession>
    <name>A0AAJ0GZ41_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Heat shock factor binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_119982</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HSBP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724611.1">
        <property type="nucleotide sequence ID" value="XM_062861614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GZ41"/>
    <dbReference type="GeneID" id="87880443"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009643">
        <property type="entry name" value="HS1-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06825">
        <property type="entry name" value="HSBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3308831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="74" mass="8054" checksum="D4C42C82294C4406" modified="2024-07-24" version="1">MDSNKDSTSTKQATSTNEDAAAELSAQLEDLLNTLSNRFAGVSSEIFAKMDEMQRRIDVLEAQLANKDKNSGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GZ86</accession>
    <name>A0AAJ0GZ86_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbon-nitrogen hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_122000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724673.1">
        <property type="nucleotide sequence ID" value="XM_062861636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GZ86"/>
    <dbReference type="GeneID" id="87880465"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008418">
        <property type="term" value="F:protein-N-terminal asparagine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070773">
        <property type="term" value="F:protein-N-terminal glutamine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07566">
        <property type="entry name" value="ScNTA1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039703">
        <property type="entry name" value="Nta1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11750">
        <property type="entry name" value="PROTEIN N-TERMINAL AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11750:SF26">
        <property type="entry name" value="PROTEIN N-TERMINAL AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3308893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="332" mass="36070" checksum="64366715C2EE5614" modified="2024-07-24" version="1">MRIGCLQFAPQVGDVSGNITRAEAVLSRADPQDLEKLDLLVLPEMALSGYNFKSLEHITPYLEPSGSGVSSQWAKSAARKYGCTVAVGYPEKVAADAAEAERYNSLIVVNSDGEKLANYRKSFLYYTDATWAREGQGFYRGELGGTFGQVAMGICMDINPYKFEAPWDAYEFGFHILRARANLVILSTAWLTNDEQTVFTSRPDAPDLSTLTYWVRRLEPIVQAGRPEETIIVFANRCGTEDEATYTGTSTVLGIKDGEVSLYGILGRGVEELLVVDTDKPPFAKLVDPSHAVDGEPSAPPAEPADRSEGHEPSKSSTSWTGSGPADSPTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GZH8</accession>
    <name>A0AAJ0GZH8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ClpP/crotonase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_125660</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724774.1">
        <property type="nucleotide sequence ID" value="XM_062861685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GZH8"/>
    <dbReference type="GeneID" id="87880514"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051750">
        <property type="term" value="F:delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.12.10:FF:000004">
        <property type="entry name" value="Delta3,5-delta2,4-dienoyl-CoA isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000024">
        <property type="entry name" value="Delta3,5-delta2,4-dienoyl-CoA isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045002">
        <property type="entry name" value="Ech1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149:SF1">
        <property type="entry name" value="DELTA(3,5)-DELTA(2,4)-DIENOYL-COA ISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149">
        <property type="entry name" value="ENOYL-COA HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3308994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="293" mass="31217" checksum="A23BD64530A7C8B1" modified="2024-07-24" version="1">MALQPQPLSAYAGYAHFIVTSPSPSHHPFVAHVEINRPAKLNAFHEAMWHELRRVFQQLSADPDVRAVVLSGAGDRAFTAGLDVTAASEGGVLASAEAQGLDAARKAARLRQYIADFQECISAVEKCEKPVICVMHGISIGLAIDISCCADIRLCSQDAQFAVKEVDIGLAADIGTLARLPKVVGSQSWVKDVCLTARDFSAVEALSVGFVSQVHESKAAALAVAVEMAGFIASKSPVAVQGTKELLNHSRDHTVDDNLRYTGVWNAAALQTNDVAAALMSGLKKKKPTFEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GZT9</accession>
    <name>A0AAJ0GZT9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_525231</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724565.1">
        <property type="nucleotide sequence ID" value="XM_062868833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GZT9"/>
    <dbReference type="GeneID" id="87887662"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22572">
        <property type="entry name" value="GCP5_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059169">
        <property type="entry name" value="GCP5_N_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032797">
        <property type="entry name" value="Mod21_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF33">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14609">
        <property type="entry name" value="GCP5-Mod21_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-Tubulin ring complex non-core subunit mod21 N-terminal" evidence="7">
        <location>
            <begin position="66"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="8">
        <location>
            <begin position="233"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="6">
        <location>
            <begin position="545"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3308785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="886" mass="100357" checksum="0684352964B71B5E" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H005</accession>
    <name>A0AAJ0H005_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_259</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725086.1">
        <property type="nucleotide sequence ID" value="XM_062863297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H005"/>
    <dbReference type="GeneID" id="87882126"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF230">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3309306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="524" mass="59596" checksum="79052593021166ED" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H024</accession>
    <name>A0AAJ0H024_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_423891</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725089.1">
        <property type="nucleotide sequence ID" value="XM_062865602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H024"/>
    <dbReference type="GeneID" id="87884431"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000085">
        <property type="entry name" value="Dihydroflavonol reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF852">
        <property type="entry name" value="CINNAMOYL-COA REDUCTASE CAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="6"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="154"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3309309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="370" mass="40252" checksum="952D50A6842A3480" modified="2024-07-24" version="1">MTARTALVTGGSGYIGLHVVNSLLEAGWTVHTTVRSLRNETKTRPLNSLADKHPGKLRLFEADLLVADSFTEAMQGCSTVIHVASPFLVPERVKNPETELIRPALEGTRNVLGSVNKTESVKRVVLTSSGAWLMQIQVVGCYTLHTLPRTLVGAMYGDAADVLQSEKATLHEGCWNTTSSPSHNAYQHSKTLAEREAWKMAEAQNRWNLVVICPGLVLGPSLSPASDSGSLALIDQLLSGLLMVGVPALSWALVDVRDVAAAHVRAGEVPEAKGRYIVAESKTTSCLELSKSFKQVHSKPRVLPTWNLPALVFRLFAPFAGLSQAWVTANWGIGFSLDNSRGIKELGITYRPVEEMLKDHYQSWAAQHQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H0A2</accession>
    <name>A0AAJ0H0A2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cell wall protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_3714</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725236.1">
        <property type="nucleotide sequence ID" value="XM_062864202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H0A2"/>
    <dbReference type="GeneID" id="87883031"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042555494" description="Cell wall protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3309456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="268" mass="27064" checksum="8049FAC403BFCF13" modified="2024-07-24" version="1">MHYPAALVALAALVAPSAASPNGWSSPKSAPDGPTKLDDCGCWPIYQAMLKCQKLKGPNSNIDDCVCIPNPDGWYTSLNGCRACLSPGSYDDNDFFDNLSRTISQLFVSCTNVGGGINSPDGESICASNYYFQACASLRTDGQPSWASYEVFKDGTGGNGTYVLDIAEYGASSSAASSATTDTATSTTATTSGSTTATGATTTDSTTGGSETTGTSVASTSTTVVETTSAPAATTSSPSSAMGYAGSRSQAGRIVGLVFAVGVAVVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H0B3</accession>
    <name>A0AAJ0H0B3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTP-binding protein EsdC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_128962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3309085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724865.1">
        <property type="nucleotide sequence ID" value="XM_062861731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H0B3"/>
    <dbReference type="GeneID" id="87880560"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40625:SF2">
        <property type="entry name" value="GTP-BINDING PROTEIN ESDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40625">
        <property type="entry name" value="GTP-BINDING PROTEIN ESDC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="246"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3309085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="277" mass="30133" checksum="AB8F5ACFDCC436B6" modified="2024-07-24" version="1">MSAIQLSFSLRVSSGVKTVHLLGSWDNYSGQLPLSKDKSSSKSGTWKGTFRFQQATLQPGQRYWYYYIIDGYHVSHNPSEDSTVEPTTGRALNILDVPKSKSSSSSSSSSSKSSSRKSTSSSKSRSSAHGDIPKGRPLSVSQIKAPKPVSPNATRHILDKDFDEDELSSRFAATGIYDDYYDEDVITDFGMPGSPVSSVGSSLSYRSDSSGSSGYSTPASDCSSCTCERYGITRKGERVRLDCGGSRCSYDDSCSSSEDEAEYIERSSRRNGIVVRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H0K3</accession>
    <name>A0AAJ0H0K3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_506375</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725401.1">
        <property type="nucleotide sequence ID" value="XM_062867568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H0K3"/>
    <dbReference type="GeneID" id="87886397"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048682">
        <property type="entry name" value="COG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048684">
        <property type="entry name" value="COG4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013167">
        <property type="entry name" value="COG4_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048680">
        <property type="entry name" value="COG4_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20662">
        <property type="entry name" value="COG4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08318">
        <property type="entry name" value="COG4_m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20663">
        <property type="entry name" value="COG4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00762">
        <property type="entry name" value="Cog4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="COG4 transport protein middle alpha-helical bundle" evidence="10">
        <location>
            <begin position="223"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3309621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="843" mass="91748" checksum="9F637602876759FC" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H0X3</accession>
    <name>A0AAJ0H0X3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_545199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725210.1">
        <property type="nucleotide sequence ID" value="XM_062870122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H0X3"/>
    <dbReference type="GeneID" id="87888951"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3309430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="213" mass="24260" checksum="2149E3C93C7A3E90" modified="2024-07-24" version="1">MPNLVAVDVFVTDNRLRLVFSDRAVAAAYAAYLRAQDLRPPHYQAIPGYERAPQLHITTKEVSLSLPDFITWFITCRLPDDEDSVTFTFMDADEDYAAHWAESMVLFEQVPPTTAPGDHHHHHHRHYHQQHHDDAKQLHVRRLWNRAHLLKRLEELIRRVSTPPTAGRERSKDGSPVWGNGVNGNGGGGGRMPVQMPLTVAAAGRMQRGDIWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H1L6</accession>
    <name>A0AAJ0H1L6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_517459</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725898.1">
        <property type="nucleotide sequence ID" value="XM_062868313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H1L6"/>
    <dbReference type="GeneID" id="87887142"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051299">
        <property type="entry name" value="AB_hydrolase_lip/est"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46640:SF1">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46640">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042527275" evidence="4">
        <location>
            <begin position="19"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="5">
        <location>
            <begin position="159"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="22"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="122"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3310118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="440" mass="48049" checksum="CC2D51CCFD2AE88D" modified="2024-07-24" version="1">MRSLKNLFLVSLLPRLSAQVDSLPQVSPQPSPFDQRHPQQHRISHDGHPQPRPGGVSTRLFATLERTARLVDITYCIGTTGISPPFSCVSRCKDFPALRLVRTWNTGVLLSDSCGYIAIDSGTGTGDTDNVDDDDDDGGVNNSDNDHGLPGEEGQREIVVAFRGTYSITNTIVDLSTVPQEYVPYPAPPEDGGGGGGGKCENCTVHMGFMASWKNAREVVLPALHAAREKYPDYRVHLVGHSLGGAVAALAALEMRMGLGWRDVAVTTFGEPKVGNDKLAEYIDRAFGLAGSDGEDVPYRRVTHVGDPVPLLPLSEWGYASHAGEIHIGKSDLPPRPEDLRLCRGDNDPECMGGAETSDWLSRVLGVLGRLKIQEEVETSVSRRGWFPARLRVWQLLFAHRDYFWRLGLCLPGGDPADWGREKHNLTSGENSGVPEIRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H1P4</accession>
    <name>A0AAJ0H1P4_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Ribonuclease E inhibitor RraA/Dimethylmenaquinone methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_386523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725680.1">
        <property type="nucleotide sequence ID" value="XM_062864327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H1P4"/>
    <dbReference type="GeneID" id="87883156"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047443">
        <property type="term" value="F:4-hydroxy-4-methyl-2-oxoglutarate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008948">
        <property type="term" value="F:oxaloacetate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16841">
        <property type="entry name" value="RraA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.40">
        <property type="entry name" value="Ribonuclease E inhibitor RraA/RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005493">
        <property type="entry name" value="RraA/RraA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036704">
        <property type="entry name" value="RraA/RraA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33254:SF28">
        <property type="entry name" value="4-HYDROXY-4-METHYL-2-OXOGLUTARATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33254">
        <property type="entry name" value="4-HYDROXY-4-METHYL-2-OXOGLUTARATE ALDOLASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03737">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89562">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="104"/>
            <end position="107"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605493-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3309900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="229" mass="24802" checksum="43C856CF213D0AF9" modified="2024-07-24" version="1">MASHDRPDSEDRIVKALQEFTTCDVSDALVKLGLHHGGFLPGITLWSPQRQDGPTKIVGPAYTVQYAPAEDPRPKWPSHYIDSVPPGAVILVTCSPRTPNALYGGLMSTRAKASGAVGSVVDGRFRDVQEQRDLDYPVFARGVGTTPPGPLFKVVAVNEPVTVSDEGQETQVNPEDYLIGDVNGVVVLPRTHAEHALPLMAKQVEADSKMAVEIQKGMTFTEASKRFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H269</accession>
    <name>A0AAJ0H269_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LSM2-LSM8 complex subunit LSM8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LSM8</name>
        <name evidence="11" type="ORF">B0T15DRAFT_37223</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H269"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01727">
        <property type="entry name" value="LSm8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000027">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034103">
        <property type="entry name" value="Lsm8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044642">
        <property type="entry name" value="PTHR15588"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588">
        <property type="entry name" value="LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588:SF9">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3310418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="97" mass="10526" checksum="FCAFE614EAE4236E" modified="2024-07-24" version="1">MSLNSYVEKKVCIITTDGRNLVGVLAAHDNTTNLVLKNTVERVIRSPDEGEPSVEVPLGLYIIRGENVCLVGLVDEPLDASINWTEVRGAPIGTTKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H343</accession>
    <name>A0AAJ0H343_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome quality control complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_519688</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NEMF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726637.1">
        <property type="nucleotide sequence ID" value="XM_062868447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H343"/>
    <dbReference type="GeneID" id="87887276"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.310.10:FF:000003">
        <property type="entry name" value="Zinc knuckle domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.310.10">
        <property type="entry name" value="ibrinogen binding protein from staphylococcus aureus domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021846">
        <property type="entry name" value="NFACT-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008532">
        <property type="entry name" value="NFACT_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051608">
        <property type="entry name" value="RQC_Subunit_NEMF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15239">
        <property type="entry name" value="NUCLEAR EXPORT MEDIATOR FACTOR NEMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15239:SF6">
        <property type="entry name" value="RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT NEMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11923">
        <property type="entry name" value="NFACT-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05670">
        <property type="entry name" value="NFACT-R_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05833">
        <property type="entry name" value="NFACT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NFACT RNA-binding" evidence="8">
        <location>
            <begin position="548"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="NFACT protein C-terminal" evidence="9">
        <location>
            <begin position="941"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="438"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="715"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="779"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="884"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1050"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="335"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="501"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="453"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="719"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="814"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="842"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="1051"/>
            <end position="1076"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00070414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3310857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1085" mass="119741" checksum="5DC394844D656A33" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H376</accession>
    <name>A0AAJ0H376_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Phosphotransferase</fullName>
            <ecNumber evidence="11">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0T15DRAFT_387770</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-fructose + ATP = D-fructose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:16126"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a D-hexose + ATP = a D-hexose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22740"/>
            <dbReference type="ChEBI" id="CHEBI:4194"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:229467"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:22741"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the hexokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="11"/>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726460.1">
        <property type="nucleotide sequence ID" value="XM_062864405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H376"/>
    <dbReference type="GeneID" id="87883234"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019158">
        <property type="term" value="F:mannokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24087">
        <property type="entry name" value="ASKHA_NBD_HK1-2_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000092">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.367.20:FF:000004">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019807">
        <property type="entry name" value="Hexokinase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF16">
        <property type="entry name" value="HEXOKINASE TYPE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00378">
        <property type="entry name" value="HEXOKINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="12">
        <location>
            <begin position="17"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="13">
        <location>
            <begin position="218"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3310680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="482" mass="53358" checksum="A83374563BB233E0" modified="2024-07-24" version="1">MALGSLENAPKDLLNEIKHLEELFTVDTPKLKQITEHFVNELTKGLSVAGGSIPMNPTWVMSRPTGHETGTYLALDMGGTNLRVCQVTLTEQKSEFDIIQSKYRMPEELKTGDADELWEYIADCLQQFIETHHGDVSKMEKLPLGFTFSYPATQNYIDEGILQRWTKGFDIAGVEGHNVVPMFEAALAQRGVPIKLTALINDTTGTLIASAYTDPKMKIGCIFGTGCNAAYIEECGSIPKLAHLNLPADTPMAINCEWGAFDNEHKVLPRTKYDEAIDNDSPRPGQQAFEKMIAGLYLGEIFRLILVDLHDNRDVHIFAGQDISKLRRPYTLDSSFLSAIEEDPFENLSETLDLFQTKLNISPNLPELELIRRTAELIGTRAARLSACGVAAISKKKGYTSCHVGADGSVFNKYPHFKARGAQALREILDWPEKTDPKEEDPIEILAAEDGSGVGAALIAALTLQRVREGNMHGILHPENFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H3E6</accession>
    <name>A0AAJ0H3E6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ribonucleases P/MRP protein subunit POP1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_51282</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726609.1">
        <property type="nucleotide sequence ID" value="XM_062868006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H3E6"/>
    <dbReference type="GeneID" id="87886835"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039182">
        <property type="entry name" value="Pop1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055079">
        <property type="entry name" value="POP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009723">
        <property type="entry name" value="Pop1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012590">
        <property type="entry name" value="POPLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22731">
        <property type="entry name" value="RIBONUCLEASES P/MRP PROTEIN SUBUNIT POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22731:SF3">
        <property type="entry name" value="RIBONUCLEASES P_MRP PROTEIN SUBUNIT POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22770">
        <property type="entry name" value="POP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06978">
        <property type="entry name" value="POP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08170">
        <property type="entry name" value="POPLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pop1 N-terminal" evidence="5">
        <location>
            <begin position="76"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="POPLD" evidence="6">
        <location>
            <begin position="560"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="POP1 C-terminal" evidence="7">
        <location>
            <begin position="745"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="172"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="514"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="689"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3310829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="936" mass="103132" checksum="2F19BF8661E69334" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H3M7</accession>
    <name>A0AAJ0H3M7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_388345</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726907.1">
        <property type="nucleotide sequence ID" value="XM_062864442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H3M7"/>
    <dbReference type="GeneID" id="87883271"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01725">
        <property type="entry name" value="LSm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000053">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016654">
        <property type="entry name" value="U6_snRNA_Lsm2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13829">
        <property type="entry name" value="SNRNP CORE PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13829:SF2">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="9">
        <location>
            <begin position="47"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3311127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="140" mass="15619" checksum="09A9C17CB4540FEA" modified="2024-07-24" version="1">MYGNGLRISHKSCLPSASGDGHTPSVGQRDPLPSPCLVLGSQKKLTRKHSFFKTLIDHEVTVELKNDIQIRGVLKSVDQYLNIKLDNIQVLEELKYPHLSAVKNVFIRGSVVRYVHLPASAVDVPLLEDATRRGELLLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H3S4</accession>
    <name>A0AAJ0H3S4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mediator of RNA polymerase II transcription subunit 31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0T15DRAFT_489613</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Mediator complex subunit 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726755.1">
        <property type="nucleotide sequence ID" value="XM_062866611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H3S4"/>
    <dbReference type="GeneID" id="87885440"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1340:FF:000002">
        <property type="entry name" value="Mediator of RNA polymerase II transcription subunit 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1340">
        <property type="entry name" value="Mediator of RNA polymerase II, submodule Med31 (Soh1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038089">
        <property type="entry name" value="Med31_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008831">
        <property type="entry name" value="Mediator_Med31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13186">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05669">
        <property type="entry name" value="Med31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0010">Activator</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3310975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="129" mass="14688" checksum="4861E06495A9A71C" modified="2024-07-24" version="1">MDSGPMSVDSSAMDAPAPSKSTADEPKYGGHSRFELELELVQSLANPLYLNYLASRKFLTNPAFVAYLDYLQYWTRPPYLKYLTHPTASLKMLQLLQQEKFRQDIMSPDLAQAMMVEGVRAAVEWHREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H4L5</accession>
    <name>A0AAJ0H4L5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit SPC19</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Outer kinetochore protein SPC19</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0T15DRAFT_508215</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex SPC19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727456.1">
        <property type="nucleotide sequence ID" value="XM_062867703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H4L5"/>
    <dbReference type="GeneID" id="87886532"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013251">
        <property type="entry name" value="DASH_Spc19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28262">
        <property type="entry name" value="DASH COMPLEX SUBUNIT SPC19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28262:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT SPC19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08287">
        <property type="entry name" value="DASH_Spc19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="103"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="166"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3311676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="201" mass="21385" checksum="8CB0563D1E7FF83B" modified="2024-07-24" version="1">MSSSSSAATYSDCVASLRTSLSFLESSVATLGAGVQDFPRLSSILKTVRHYELIPQPTLAAAEASLHDEIGPFVALLLDRADKHLERQARRIETLKARADLNAGRLSHYPPPPASSSSGQEIGGGRSGGSKNLAGAAKGQGKERGGGKQGGGGGRRPLDGGAALRAKVVRQRKEALKYSVERLELEVLQKERELRMRLEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H4W3</accession>
    <name>A0AAJ0H4W3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_521947</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>oxaloacetate + acetyl-CoA + H2O = citrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16845"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>propanoyl-CoA + oxaloacetate + H2O = (2S,3S)-2-methylcitrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23780"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:58853"/>
            <dbReference type="EC" id="2.3.3.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Organic acid metabolism; propanoate degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the citrate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727370.1">
        <property type="nucleotide sequence ID" value="XM_062868591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H4W3"/>
    <dbReference type="GeneID" id="87887420"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050440">
        <property type="term" value="F:2-methylcitrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.230.10:FF:000001">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.580.10:FF:000001">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007128">
        <property type="entry name" value="PRK09569.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739:SF15">
        <property type="entry name" value="CITRATE SYNTHASE 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3311590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="475" mass="52466" checksum="3966C33DF1ADBFBA" modified="2024-07-24" version="1">MALNLRTGRHALRGALRPIVATPSHASARRTYATAEPDLKTTLKEVIPAKRELLKKVKAHGSKVIGEVKVENTIGGMRGLKAMVWEGSVLDANEGIRFHGRTIKDCQKELPKGKTGTEMLPEAMFWLLLTGKVPSVNQVRQFSRELAEQGQLPTFVSKMLDDFPRDMHPMTQFAIAVSALNYTSKFAKAYEKGLNKADYWEPTFDDCISLLGKLPTIAAKIYQNSYRGGGPLPAEIDLEQDWSYNFAAMLGKGGRENENFQDLLRLYLALHGDHEGGNVSAHTTHLVGSALSDPFLSYSAGLQGLAGPLHGLAAQEVLRWILQLQSTLPTSYTEDDIRSYLWTTLNSGRVVPGYGHAVLRKPDPRFEALMDYAASRPEISEDPVFQLVRKTSAVAPEVLKQHGKTKNPYPNVDASSGVLFHHYGFTETLYYTATFGVSRGLGPLAQLIWDRALGLPIERPKSVNLEGILKQVEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LYH1</accession>
    <name>A0AAJ0LYH1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_298318</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718033.1">
        <property type="nucleotide sequence ID" value="XM_062863788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LYH1"/>
    <dbReference type="GeneID" id="87882617"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008506">
        <property type="term" value="F:sucrose:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000593">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432:SF35">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 45 MEMBER 3 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432">
        <property type="entry name" value="SUGAR TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13347">
        <property type="entry name" value="MFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="461"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="485"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="570"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="602"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="528"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="630"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="645"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3302253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="681" mass="74429" checksum="2146871DDC11CB73" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZS0</accession>
    <name>A0AAJ0LZS0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidase signature domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_560867</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719474.1">
        <property type="nucleotide sequence ID" value="XM_062870542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZS0"/>
    <dbReference type="GeneID" id="87889371"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46310">
        <property type="entry name" value="AMIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46310:SF7">
        <property type="entry name" value="AMIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="48"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3303694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="442" mass="49544" checksum="2F3B7EC4C934ABEE" modified="2024-07-24" version="1">MESVDDDIIFVRDSIRYAAIGAIPFNPQPGLRVAVPARYSKEWDHSARGLRVVVKDVFRIKGLKTSLNNRAYYEISEPAEFTASVIATPACDGAHILGMTKLSWMIAREEPLDAVDFPTAFNPRGGGYESPAGSSSGTAAAVAAYEWVDCGIGTDTSGGGRRPAVANGIWHHDRDIANHNVKIKHEIDDDDCLVITSTQDRRPSYEIVYLVDHLPVENKEQMALIHGFLIDAVARLPATIRKSSIRESWRCSHPQGTSDDIDEYLRDVITRTYYYAFYHSTDGFREEYAKRHGGRTPYVIPFVQRRWEKGAAVTAAQHREAEDKLMVYRDWLMRTIFYHDTPQEQQKQVFGILPISNVAPNYRDMPSPSPEEQSALDEMFLPPILGAPDITVPIGDVPYESRITGQTEYLPVVVDLMAAPDKDWLMTAVEKIMKLSGRPTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M030</accession>
    <name>A0AAJ0M030_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_227689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719816.1">
        <property type="nucleotide sequence ID" value="XM_062862901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M030"/>
    <dbReference type="GeneID" id="87881730"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="269"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3304036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="329" mass="37268" checksum="9CB15856243D16E0" modified="2024-07-24" version="1">MSVKFRRSSPNGGYEHQRSDSGFSDCESHTSTPDRGYLVPGNEEPGIYSIRRALESSRQECDEAKARAKELERTLKKVTTELEEAKARMRALSNENENLVEEKKSLTKSNKELAEQNAQLEETVKELNKDLKKANRKSNSGSSPSGSSGNASESSDEKKLHRSSSKRRKEPSGRTEKEKERDREREKEKEKERARERRKEEKAAQEEQDRLDRLRQRFDSRGEESDAKSSSTSTRSQRNRSDSYIEPLGHPAPRPQVSVTGPLAPTRQYSSYAPTTTPAYSTAQSYQSIREPYSATTPRPHHPAVYVAADTYGVADDQYAVPRSTRHAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M0A0</accession>
    <name>A0AAJ0M0A0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein transport protein SEC31</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein transport protein sec31</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B0T15DRAFT_535897</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">COPII-coated vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat SEC31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720026.1">
        <property type="nucleotide sequence ID" value="XM_062869529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M0A0"/>
    <dbReference type="GeneID" id="87888358"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007029">
        <property type="term" value="P:endoplasmic reticulum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.940.10:FF:000007">
        <property type="entry name" value="Protein transport protein (SEC31), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000193">
        <property type="entry name" value="Protein transport protein SEC31, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024298">
        <property type="entry name" value="Sec16_Sec23-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040251">
        <property type="entry name" value="SEC31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009917">
        <property type="entry name" value="SRA1/Sec31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923">
        <property type="entry name" value="SEC31-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923:SF11">
        <property type="entry name" value="SECRETORY 31, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07304">
        <property type="entry name" value="SRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12931">
        <property type="entry name" value="TPR_Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="7 15" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="115"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="166"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="249"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Sec16 Sec23-binding" evidence="18">
        <location>
            <begin position="561"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="domain" description="SRA1/Sec31" evidence="17">
        <location>
            <begin position="1113"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="472"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="799"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="876"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="481"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="821"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="836"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="894"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="960"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="1005"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1039"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="1063"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1130"/>
            <end position="1140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF07304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF12931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAK3304246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1254" mass="133772" checksum="19DA2DC34B38531B" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M0A8</accession>
    <name>A0AAJ0M0A8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_418112</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719953.1">
        <property type="nucleotide sequence ID" value="XM_062865502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M0A8"/>
    <dbReference type="GeneID" id="87884331"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000127">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15710">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PRAJA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15710:SF228">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="277"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="52"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="151"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="328"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="154"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="167"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3304173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="356" mass="38726" checksum="56F20CC060F7DCF9" modified="2024-07-24" version="1">MADQGRHEDMYCHACHHQWRRQGNGMECPACGCMSTEIIDSQHDPRNFHNRQRTAVNSDPLPAPHISDTSSTSTVSSPPSQPGLEGANSSSTAQHTSGSTPQPAATRIQISPVTFVSFSVPLSSMPQGSQVPPPTHPEVFDTQIFPFVITFSRPPTTNTSSTNPTTHDQNNEQTNNQHSETQQSDAQAQQPLQPGIDAWFQHVPSLFFRLMSTGHLFNPANAIFGDAVYSQEALDRIISQLREQEAAGGAPPASQAAIDRLQTKELDDKMLGVCSKCVICVDDLLKGEKAAVLPCDHFFHGECVTPWLKQHNTCPVCRRSIEVERDEGKNVKTAGMSPSAPQSEARNGASDAMNCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M0S6</accession>
    <name>A0AAJ0M0S6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_495212</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720555.1">
        <property type="nucleotide sequence ID" value="XM_062867082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M0S6"/>
    <dbReference type="GeneID" id="87885911"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052982">
        <property type="entry name" value="SRP1/TIP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633:SF1">
        <property type="entry name" value="GPI ANCHORED SERINE-THREONINE RICH PROTEIN (AFU_ORTHOLOGUE AFUA_1G03630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633">
        <property type="entry name" value="MATRIX PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042572867" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="4">
        <location>
            <begin position="23"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="5">
        <location>
            <begin position="33"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="118"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3304775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="265" mass="28646" checksum="4145583C40E5847F" modified="2024-07-24" version="1">MARRSTRATLLAQLLLLPAVLAAVSFANTDYYVYPTVPFTITWTDARGPVNITLMNGPDEYLKDVLLIVTAFAGAEDYTWTPPPTVPPDSYILRIEDGGSTDYSPRFVYPGPVLTTTATRSPSATSASPATTSITSTSTNTAQQQPQSQNNNELLSTPAKAVIATLGSLLLVILLASLLRYYCLCSKRRRRQLREAERAAAAATAASHELPPLSPRSGDDAETIHLHGNMMIKAEGQEGNVVELPVRGWGEMVELSADSNRKPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M108</accession>
    <name>A0AAJ0M108_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_502223</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Intramembrane glycolipid transporter that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. RFT1 could mediate the translocation of the cytosolically oriented intermediate DolPP-GlcNAc2Man5, produced by ALG11, into the ER lumen where dolichol-linked oligosaccharides assembly continues. However, the intramembrane lipid transporter activity could not be confirmed in vitro.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the RFT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720807.1">
        <property type="nucleotide sequence ID" value="XM_062867423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M108"/>
    <dbReference type="GeneID" id="87886252"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034203">
        <property type="term" value="P:glycolipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007594">
        <property type="entry name" value="RFT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13117">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MULTISPAN TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13117:SF5">
        <property type="entry name" value="PROTEIN RFT1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04506">
        <property type="entry name" value="Rft-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="401"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="439"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="463"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3305027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="580" mass="61325" checksum="0727E34B76022FE1" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M1C9</accession>
    <name>A0AAJ0M1C9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aldehyde dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_194180</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 8">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721122.1">
        <property type="nucleotide sequence ID" value="XM_062862487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M1C9"/>
    <dbReference type="GeneID" id="87881316"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006081">
        <property type="term" value="P:aldehyde metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07135">
        <property type="entry name" value="ALDH_F14-YMR110C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000025">
        <property type="entry name" value="Aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000004">
        <property type="entry name" value="Aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570:SF11">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036492">
        <property type="entry name" value="ALDH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="9">
        <location>
            <begin position="9"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="active site" evidence="6 7">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR036492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR036492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3305342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="531" mass="58863" checksum="4D0C5361F3ABCEEB" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M1E6</accession>
    <name>A0AAJ0M1E6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_197217</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721226.1">
        <property type="nucleotide sequence ID" value="XM_062862530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M1E6"/>
    <dbReference type="GeneID" id="87881359"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052783">
        <property type="entry name" value="Metabolic/Drug-Res_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655">
        <property type="entry name" value="QUINIC ACID UTILIZATION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655:SF2">
        <property type="entry name" value="QUINIC ACID UTILIZATION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="44"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="152"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="612"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3305446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="793" mass="85609" checksum="E31E7E3DE80B9BB6" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M1J9</accession>
    <name>A0AAJ0M1J9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Armadillo-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_201377</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721332.1">
        <property type="nucleotide sequence ID" value="XM_062862578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M1J9"/>
    <dbReference type="GeneID" id="87881407"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041653">
        <property type="entry name" value="Importin_rep_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040928">
        <property type="entry name" value="Importin_rep_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041389">
        <property type="entry name" value="Importin_rep_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057672">
        <property type="entry name" value="TPR_IPO4/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18808">
        <property type="entry name" value="Importin_rep_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18816">
        <property type="entry name" value="Importin_rep_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18829">
        <property type="entry name" value="Importin_rep_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25780">
        <property type="entry name" value="TPR_IPO5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="8">
        <location>
            <begin position="30"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3305552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1096" mass="122006" checksum="5ADFF395706C210C" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M2C5</accession>
    <name>A0AAJ0M2C5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_491930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722158.1">
        <property type="nucleotide sequence ID" value="XM_062866818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M2C5"/>
    <dbReference type="GeneID" id="87885647"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3306378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="104" mass="12232" checksum="2B6044E57157B0A4" modified="2024-07-24" version="1">MTASTAMRYHLLNQEVFDAGYNYSALPAHARDAVKSEEENLRKFVSAPWDMYTKHIFPKIGYVAKAERVESNDFYVPQTRQRGYLVAMDVQYLFWHRLGHQVCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M2F3</accession>
    <name>A0AAJ0M2F3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0T15DRAFT_223147</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3306259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722039.1">
        <property type="nucleotide sequence ID" value="XM_062862835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M2F3"/>
    <dbReference type="GeneID" id="87881664"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="9" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042497558" description="CFEM domain-containing protein" evidence="10">
        <location>
            <begin position="18"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="11">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="50"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3306259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="97" mass="9695" checksum="F01518B083202ACD" modified="2024-07-24" version="1">MHFSTILIATLAAAVSAGPTMKRQAACPEVDNIPACGYPCIADAVAAVGCAETDYSCMCGNFDTVQSGATSCVLANCDLTNALAVLSAARAVCDACA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M2N9</accession>
    <name>A0AAJ0M2N9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_552940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3307577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="497" mass="52762" checksum="C19A743300469CA9" modified="2024-07-24" version="1">MSSHSKEEKPEPANPAVPSSNAGTSEQVTSTKRSAADDELQFISSNPVKKRRPIAQKRLEMTQPPDTLALPLSNTQQNVTRLRAHVDMARPSAMSSQTPAIDQQQTTASSQVPERCRSLAPASEATRPAPNPPLESRGASLPVLENFAFPQSSAPQPIRPTPSSEAVSPKQLPQGPPSSLGADARNQSVAPTPDVPSQNSVTLNQISCLDVNGVPTNTPGFELGPIFSANGSVISGSGMGNMRSSEAVPAPPLGPAMPPFNPMASPNAIPFTMYSTGNIVTIPQMQHCMSPLPASFPPGAMQPPPQHGRVSIPGNQTQTQTTMQPAVPGLPHGAHTHTTHGRSSSPHPAYRPPCLHCERIRQENLLRRAHGSPRLPASADPRHLPEGQGQSSQHSSLSPTSSHVRHPTPAEQPGPTPRSTPAFRQPAQEHSQFQHRWPAPPAPPVSLGLSPSRSIVQDIADTVRASFPYVQVAARHGMTPAKVAELLSRILVPTTVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M3G5</accession>
    <name>A0AAJ0M3G5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_484726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723450.1">
        <property type="nucleotide sequence ID" value="XM_062866240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M3G5"/>
    <dbReference type="GeneID" id="87885069"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="8"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3307670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="140" mass="15791" checksum="170C9D37DAB8ADF6" modified="2024-07-24" version="1">MTTPPPDYTRFADTKQWNKFDTIFVPDATFTFVDIDGKVISTPDGAIPYKWYSLESWVAFFEKALADLQVIHLTGPGEFELVGPNEVKAVFTVVYNDALKGGGTGPHETGGGHYYETWVRQSGDLFCKDLCMQRTYHRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M3M6</accession>
    <name>A0AAJ0M3M6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_493008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723314.1">
        <property type="nucleotide sequence ID" value="XM_062866906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M3M6"/>
    <dbReference type="GeneID" id="87885735"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3307534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="504" mass="54340" checksum="33A7D6DC7AB8BA16" modified="2024-07-24" version="1">MSRMELRPAALRRRPGRYREDDGPTRAERPAFVHPDVPFNERLAEFCAHPTLPLDYPGVGPAEAERLRLAAVAAAGAEQADVTDDEHHSSEEGSKNDDDDSDHEGAGAVTNHGAESQDQSGEERVVDEGPRPATGDGPVAASQSVAPVNPDVGQGRRARPAYVANIPRQQPSKTNRIGEAPAFPPPAATPSPTISTNPPEQLNWSDLSDGIKYAIVFEMTREMRLSEALQQLNLTHDEVQSFLVLVQKEIEKIETCDANLEELLDFDDPSVRATIAALAPVTDPLTAAEVRRGRSYLRLLGINHVAANLGLWEGTAGTWHRIDIDEGCLDLLGVDNLGGVDLVSGSSSDVMSNMSDAELLVRLDPPARTLNPQRLRSGAPPSERGRACDLQRVPKSGSLHPANYVHSAKSGRSYSILDKSDWPQWEALHDAGIIPQTVLTVATMQSQVPNEVWYLSGEEAEAMDVDRPEELLGSLPAPDQGFIDAVVGPEPSPGSAQGNESQNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M4K8</accession>
    <name>A0AAJ0M4K8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Small acidic protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_113323</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724409.1">
        <property type="nucleotide sequence ID" value="XM_062861528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M4K8"/>
    <dbReference type="GeneID" id="87880357"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026714">
        <property type="entry name" value="SMAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028124">
        <property type="entry name" value="SMAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22175:SF0">
        <property type="entry name" value="SMALL ACIDIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22175">
        <property type="entry name" value="SMALL ACIDIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15477">
        <property type="entry name" value="SMAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small acidic protein-like" evidence="4">
        <location>
            <begin position="294"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="48"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="145"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="223"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="272"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="318"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3308629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="370" mass="40959" checksum="99AB57FF45C37911" modified="2024-07-24" version="1">MGEKSKKKALEPKNDAAALEGAADTSMKEKIKKSNADQSTLPESETVEVPRPKEEHKDDDKKSKKEKKKHGKRKREATDLPAETETTSEVKGVTEAEQAEPPKKKKKAGSPDADDKAEKKKRKKDKDKKKTKDQASGKETQVSGGKDEQDIAKTDQTDNRGKYDDKVKKETESKEVDMAEATDAPPSEVKEERPWQKARREKRERKKAEKAEKKLKRKGKNGNAEREVDEEERRMREEKKRRKEAKYGPRGKGKKGKKSKASGGSEDVPKQDAPAPASTSAPSAAPDANLSERWNVQQLDGGAKRQDKFMRLLGGKKQGTTNATAGTGQAKDGARKRLDIGQVSQELEKQFNAGVQMKFGTGGQRRGLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M560</accession>
    <name>A0AAJ0M560_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_3859</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725248.1">
        <property type="nucleotide sequence ID" value="XM_062864300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M560"/>
    <dbReference type="GeneID" id="87883129"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF2">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3309468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="517" mass="58465" checksum="DF80A2FE6CEBFF45" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M569</accession>
    <name>A0AAJ0M569_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">GPI transamidase subunit PIG-U</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_424190</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725278.1">
        <property type="nucleotide sequence ID" value="XM_062865608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M569"/>
    <dbReference type="GeneID" id="87884437"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009600">
        <property type="entry name" value="PIG-U"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13121">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13121:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN ANCHOR BIOSYNTHESIS CLASS U PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06728">
        <property type="entry name" value="PIG-U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="139"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="221"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="384"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3309498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="428" mass="47618" checksum="3AF683DEEB476FBD" modified="2024-07-24" version="1">MDGAKATPGRAVGAVDLYVSAAALRLAILALLPGLPVLLTGRVEISTPVTSFKRLQEGLFLYNHNVSPYDGGVYHQAPLFLPLFSLLPSFLTFPIFTYLLYIAVDLLSANALWRIAESGEAGSSARFTSARREKRWSGFVIAALFLFNPFTVATCIGRSTSVFTTCAILHAIAKAVSGSPFGAMVALSFASYLSMYPLLLLPPLILLCYDRQRPERATKSGLKFSATCVSVVAGVLALLFQMSYLITGSWEFLPSTYGVQLTLSDLTPNVGLWWYFFIEMFDSFRSFFLAVFWLHLSSYVGALTLRIRRQPLVVLTLLLGIFAIFKPYPSISDTSLFLAMVPLYRHVFPLMRYTFVIAAVIMYATFLGPAFYHLWIYAGSGNANFFYAITLVWGLGQSLLVCDLMFAVLRDEWEVERPEMVGKEIRQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M5C2</accession>
    <name>A0AAJ0M5C2_9PEZI</name>
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        <submittedName>
            <fullName evidence="4">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_515343</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725157.1">
        <property type="nucleotide sequence ID" value="XM_062868182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M5C2"/>
    <dbReference type="GeneID" id="87887011"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="175"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="3">
        <location>
            <begin position="345"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="689"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="708"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3309377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="851" mass="94688" checksum="14183FBDFB588B06" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M5P4</accession>
    <name>A0AAJ0M5P4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Capsule polysaccharide biosynthesis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_545740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725532.1">
        <property type="nucleotide sequence ID" value="XM_062870140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M5P4"/>
    <dbReference type="GeneID" id="87888969"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3309752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="395" mass="44512" checksum="184E95AA74672D1E" modified="2024-07-24" version="1">MSSTSSSFSVPIPAEYQQDLDDEEILASLGQYAPVTSERNVWAFWDKGVAVMPGWCKRNVTNWVRILGPSWTVRVLDMVSDSPNHTLKYLPADFLPETFVHGTMDGPYVGPHSADFIRGAALYLHGGVFMDVGIMLIRHLDRVCWDALADEASPLRVSVPLTYGQIIANHFVAARKGDPYIKRWHDLFLHVWHGRTNYRGIIKHPVLQFALTTSSFDESKEASFNWNFKVDPETVFEYIAQVVCRTRLTHLDDAGDGFSCADYWEKKVLTFRAVDENWGAESMVGFEGPKLRDLLALRLDSEPSTPEYAKASNLVWRLLTRSSMQKVSHGKGLTSDVMLGALWDMPENETADCAPGTFAWLLRQGPLCLRQTRAAVQIVPAPPVKERWRKGVLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M5R5</accession>
    <name>A0AAJ0M5R5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_24912</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725893.1">
        <property type="nucleotide sequence ID" value="XM_062863147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M5R5"/>
    <dbReference type="GeneID" id="87881976"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3310113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="130" mass="14989" checksum="6320605DC7D0C026" modified="2024-07-24" version="1">MLDAKHHVGTSRVYSLENIMICFIPFLLILLWLSLSFFSISFFCVFVTLFFLFTYCFSSFSLSSSCSLSFPSPFLLSLLCFTVLVISIWAIDSLYGLFPPWVDKYYGVPEERADWSRKRAGPVEFRVTPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ0M6Z3_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_61876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726897.1">
        <property type="nucleotide sequence ID" value="XM_062871133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M6Z3"/>
    <dbReference type="GeneID" id="87889962"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="16"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="581"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="712"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="607"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="715"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3311117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="790" mass="86461" checksum="2865EFAE7E6373FF" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ0GKN9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717483.1">
        <property type="nucleotide sequence ID" value="XM_062870067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GKN9"/>
    <dbReference type="GeneID" id="87888896"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015109">
        <property type="term" value="F:chromate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003370">
        <property type="entry name" value="Chromate_transpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02417">
        <property type="entry name" value="Chromate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3301703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="96" mass="10552" checksum="3D98A2BB2925FA85" modified="2024-07-24" version="1">MQVEAVLLGAWLPQSVFIDGIAIGNIMPAPLAIFATFVGFQGAYVYGKWVAWQRVCRGCHHHPRDVFPCFLRSWVGISSSLAFSTVSVARSLVVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GKV2</accession>
    <name>A0AAJ0GKV2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_563457</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062870617.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87889446"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="2"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3301809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="108" mass="12055" checksum="DBD48615D86A9E82" modified="2024-07-24" version="1">MATEEQIKRAHRKKVLKHHPDKNATSSRATSTCKSPHRSISNPGKTVKLPTDCDAELRNGAAFYEFIKSLTANAKNDLLTLRSAPPGLKARHRKHLFGQKRSSAFVLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GL97</accession>
    <name>A0AAJ0GL97_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_289308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717800.1">
        <property type="nucleotide sequence ID" value="XM_062863687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GL97"/>
    <dbReference type="GeneID" id="87882516"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3302020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="272" mass="29230" checksum="51CA1836BF3C6918" modified="2024-07-24" version="1">MSHPPMKHAQALLSSARLTAEVIHMTNRSCEATAAGSCDAAVFQPGHARLRLSRLSNHLVRGSIRRLPSPIPNFPTRSSSVVDRPADHTTLKAGMVSPRCPPASAASPDSGWYVCSSPRGQASAVFAHANPTLAPVTNASPCVSGVQGRPQGSSASRRVTGFPGMLTPRNSALTSSSAKSHCLSLNLCYNFGSCRPRDHARVPREPELVDHSVSRNQKILPGPGKNMPGRAIPPSLFWYSGWRARTMSPRIRQYLASRWGHSGPGESCKWLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ0GLX4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AA1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_301686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718117.1">
        <property type="nucleotide sequence ID" value="XM_062863819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GLX4"/>
    <dbReference type="GeneID" id="87882648"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042618789" description="AA1-like domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3302337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="22842" checksum="9463612EC2D56EFB" modified="2024-07-24" version="1">MPSASHILSMLGLVALPLVNSLPNHLEALLHEPGITNRNRAQVMDVSMLNFAPWNITDLHILCNRPNTTADYTCNLTYHVFDPNSVRENKLTSGDCQIDWSWDGHTHHNADGDGSNPVVGYRPCVNDQRTFIKSSVVNFWHPGNFTIEVVHHYHDNENFTYPWDYPTTFAHADILICEEQALQNTMEHRLPSIDAPVVGCLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GM68</accession>
    <name>A0AAJ0GM68_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_514292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718025.1">
        <property type="nucleotide sequence ID" value="XM_062868108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GM68"/>
    <dbReference type="GeneID" id="87886937"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3302245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="168" mass="17794" checksum="1024160959C72426" modified="2024-07-24" version="1">MSSQNPTTPVKVPSSAANYTAATLDQDLRSQINSILIKEGHVTKIQEHLLHALHAHPSNWPTTIQNHALALLRSGDVTTFPALLRRVIEDVRQDTALSPNANGSKAANGDAEENGSGGVNGRKSEGINGVGSNARPSLAVPQSVVEQALKVTRECLESVCEIDENGTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GM99</accession>
    <name>A0AAJ0GM99_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Histone-fold-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_309305</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NFYC/HAP5 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718328.1">
        <property type="nucleotide sequence ID" value="XM_062863903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GM99"/>
    <dbReference type="GeneID" id="87882732"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016602">
        <property type="term" value="C:CCAAT-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22908">
        <property type="entry name" value="HFD_NFYC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000017">
        <property type="entry name" value="Ccaat-binding factor complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF8">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="9">
        <location>
            <begin position="83"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="172"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3302548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="265" mass="29282" checksum="C84F195B199877F5" modified="2024-07-24" version="1">MDPQNPSSAQHGQHGQQPRQMPVYDLSHGGHYGASSAISQQGFAPSELYTGTWANVHQGLTGHYKDVLTAYWQHTIQHLESDTHDYKMHQLPLARIKKVMKADPEVKMISAEAPILFAKGCDIFITELTMRAWIHAEENKRRTLQRSDIASALAKSDMFDFLIDIVPREEASSHAKRTSNQAAAQPAAPQPQIPGVGAPNHGQHQMAAPEYTLGHGMGPEADYRQPQTMYAGQVQPGAPPYGQPQAQMYNVDEMYYGAMPPQQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GMA1</accession>
    <name>A0AAJ0GMA1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_309135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718322.1">
        <property type="nucleotide sequence ID" value="XM_062863900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GMA1"/>
    <dbReference type="GeneID" id="87882729"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3302542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="585" mass="63049" checksum="913457DA66819FED" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GMF6</accession>
    <name>A0AAJ0GMF6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_304570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718190.1">
        <property type="nucleotide sequence ID" value="XM_062863850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GMF6"/>
    <dbReference type="GeneID" id="87882679"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3302410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="189" mass="21572" checksum="CBE952164B1D7331" modified="2024-07-24" version="1">MRLLHLAGGAHMRAGGRIPFSFSIFQPSFVWSLSSNSNKRRFFVWLLASSSLILVHIYRHFTYKTSPLHLRLLIQHYPPSNIRLAPAFQPIVSQAHAELVDTCGTEELECWCLIQNPVITRKTAGKQQPAYNVTASWHCLGPKLAQSVWTFPPRDQAFKHALRLADEQSTLIRLLKEQSNGVKESLWRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GMJ1</accession>
    <name>A0AAJ0GMJ1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycosyl hydrolases family 43-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_313367</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718503.1">
        <property type="nucleotide sequence ID" value="XM_062863957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GMJ1"/>
    <dbReference type="GeneID" id="87882786"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23265">
        <property type="entry name" value="beta-trefoil_ABD_ABFB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18817">
        <property type="entry name" value="GH43f_LbAraf43-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036195">
        <property type="entry name" value="AbfB_ABD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43817">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43817:SF1">
        <property type="entry name" value="HYDROLASE, FAMILY 43, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110221">
        <property type="entry name" value="AbfB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042505762" evidence="6">
        <location>
            <begin position="29"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3302723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="481" mass="52741" checksum="0E402C8982CDE9F3" modified="2024-07-24" version="1">MHITGRIFTAVSVFTAAWLMAVSTPAAASPAVSYANSLIQQRADPHISKHDGWYYFTATVPEYDRIILRRAQSIQTLASAAETTIWRRKASGYGSGQVWAPELHFIDGKWYVYVALGVANQWNIRTFVLEGTGANPLTASWVEKGQIRTNWDTFTLDASTFVANGTRYLIWAQGIPDRPDENSSIMIAPLENPWTIRGRAVAISHPGLPWERIGYKVNEGPYVIQRNGRIFLTYSASATDYNYCMGLLTASAGSDLMNPASWSKSQTPIFTSNAKTNQWGPGHNSFVESEDGQSDIMVYHDRGYRDIRGDPLNDPNRRTRVQKVYWKDDGTPDFGIPVPEGNTPVRLRSAADHGTYIRYYTGSASPTGTPALADTQFRIVSPGLAGGSTISLESTSNPGMFLRRAGGAEVQFVKDTTLTTADTKASASFNRVPGLADVEGVSLELSDAKAQYLSLRPSGKLVVAPVNGQVEEQKLATFFSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GML4</accession>
    <name>A0AAJ0GML4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_369339</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718523.1">
        <property type="nucleotide sequence ID" value="XM_062864189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GML4"/>
    <dbReference type="GeneID" id="87883018"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3302743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="118" mass="13337" checksum="ABFCFEE22DB5EF19" modified="2024-07-24" version="1" fragment="single">MGDLHVVVAICKKRPGDARHWILMLAEDDAENATWYHSVDGPTKGKPYKLDIAVKRFRSQGVDKHYKIATIPAKEKNKVKAAAQNTPVKFCQRWVVDVLAVLEKKSLVPQGTAHTWYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GNI2</accession>
    <name>A0AAJ0GNI2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase A4 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_266522</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718971.1">
        <property type="nucleotide sequence ID" value="XM_062863413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GNI2"/>
    <dbReference type="GeneID" id="87882242"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070007">
        <property type="term" value="F:glutamic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13426">
        <property type="entry name" value="Peptidase_G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.700">
        <property type="entry name" value="Peptidase G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000250">
        <property type="entry name" value="Peptidase_G1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038656">
        <property type="entry name" value="Peptidase_G1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536:SF1">
        <property type="entry name" value="ASPERGILLOPEPSIN, PUTAITVE (AFU_ORTHOLOGUE AFUA_7G01200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01828">
        <property type="entry name" value="Peptidase_A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00977">
        <property type="entry name" value="SCYTLDPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042577424" evidence="3">
        <location>
            <begin position="20"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="28"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600250-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3303191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="277" mass="28995" checksum="637B5A0C1EDB663F" modified="2024-07-24" version="1">MKPITLISAALAGFSTVLASAAHQQQFPSVRRSRLRPRAALSAPSTDDETNPPDETYNGNWAGAVLTGAGYRTVTGTITLPPLRLPPGADSNVLHAVSAWVGIDGQPPCPNAILQLGVDMYLNASEPSYSAWIEWYPNHSTYLTDFAMLPGDRVTLNLTAPSLSSAAFTLANHRTGQTDRASLTDQQPLLCGFSAEWMVEDFLGSNGVPLVDFGSVTFTGAKFATDTGVTGGVADAGLQGIREKADGPVVVECGKVGGDSVTCVYQGPGSADDVHLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GP22</accession>
    <name>A0AAJ0GP22_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucanase</fullName>
            <ecNumber evidence="9">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0T15DRAFT_420764</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains.</text>
            <dbReference type="EC" id="3.2.1.91"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 7 (cellulase C) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719287.1">
        <property type="nucleotide sequence ID" value="XM_062865544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GP22"/>
    <dbReference type="GeneID" id="87884373"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016162">
        <property type="term" value="F:cellulose 1,4-beta-cellobiosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07999">
        <property type="entry name" value="GH7_CBH_EG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.100.10:FF:000001">
        <property type="entry name" value="Glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.100.10">
        <property type="entry name" value="Glycoside hydrolase, family 7, domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001722">
        <property type="entry name" value="Glyco_hydro_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037019">
        <property type="entry name" value="Glyco_hydro_7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753">
        <property type="entry name" value="1,4-BETA-D-GLUCAN CELLOBIOHYDROLASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753:SF2">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00840">
        <property type="entry name" value="Glyco_hydro_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00734">
        <property type="entry name" value="GLHYDRLASE7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042607993" description="Glucanase" evidence="11">
        <location>
            <begin position="18"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3303507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="455" mass="48681" checksum="2943801F83170A0F" modified="2024-07-24" version="1">MISKIFALGALLGAAAAQQVGTQTAETHPRMTWQKCSSSGSCTNVNGEVTIDSNWRWVHDKNGYTNCYEGNTWNTTICKDGKTCASNCALDGADYSGTYGASTSGNALTLKFVTKGSYSTNIGSRLYLMASSSKYQMFTLLGNEFTFDVDVSKLGCGLNGALYFVAMDEDGGASKYSSNKAGAKYGTGYCDAQCPRDLKFINGEANANDWKPSTNDQNAGVGQYGSCCTEMDIWEANSISTAVTPHPCTTIGQHRCEGDSCGGTYSDDRYGGTCDPDGCDFNAYRQGVKDFYGPGMTVDTTKKFTVVTQFIKGSNGELSEIKRFYVQGGQVIANPDSAIEGNPGNSITPDFCKSQKVAFGDQDVFEQKGGFSQFSKGIATPMVLVMSLWDDHYANMLWLDSTYPTDASPDEPGKGRGTCDTGSGVPADIEASQASNQVIYSNIKFGPIGSTFKQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GP51</accession>
    <name>A0AAJ0GP51_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_496068</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719301.1">
        <property type="nucleotide sequence ID" value="XM_062867155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GP51"/>
    <dbReference type="GeneID" id="87885984"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3303521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="149" mass="16006" checksum="04524F6262BC31EB" modified="2024-07-24" version="1">MAETTGDFPLARADDGSYAGPEDTFDGSVAGASGTSTGGMVLSSGALAAIIVVVVLVALVGIASMVLFWVAKKREWTVKETLRRSARKVVTALTPRRSEFPKSVKESSGRGGRSRLDDVPPTPRIKPEYLDLEKGLEKPKKKRANFSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GPH4</accession>
    <name>A0AAJ0GPH4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_513699</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SH3YL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719315.1">
        <property type="nucleotide sequence ID" value="XM_062868060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GPH4"/>
    <dbReference type="GeneID" id="87886889"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11842">
        <property type="entry name" value="SH3_Ysc84p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11525">
        <property type="entry name" value="SYLF_SH3YL1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000100">
        <property type="entry name" value="SH3 domain-containing YSC84-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051702">
        <property type="entry name" value="SH3_domain_YSC84-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033643">
        <property type="entry name" value="SYLF_SH3YL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007461">
        <property type="entry name" value="Ysc84_actin-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629:SF2">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING YSC84-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629">
        <property type="entry name" value="SH3YL1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04366">
        <property type="entry name" value="Ysc84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01887">
        <property type="entry name" value="SPECTRNALPHA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="338"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="245"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="291"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="313"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3303535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="398" mass="41733" checksum="15E957E4C67A3D1C" modified="2024-07-24" version="1">MGINNPLPSSLASECKKCGKILTSFIDPRQAFGPDKVIPPSVLAGAKGLAILTVIKAGFLGSARFGSGLVVARLPDGSWSAPTAIATGGAGFGGQIGFELTDFVFILNDASAVKTFSQAGSLTLGGNVSIAAGPVGRNAEAAGAASLRSVAGIFSYSKTKGLFAGVSLEGSMIIERKDANTKLYGRPISARELLSGSERPPPQAAPLLNVLNSRVFSGVSPGTMDDRMYNDVPVYDDHRDDVVWGNSAGSGYREGQPRDNGHGSGGQAHDEFDRPKRSSTWQDDVYDQPRSFGQGSRSNTFSDGFGGSGAAGNGAAKKVGPGRPAAPKPNYASKEALMKKNEAIALYTFEADQPGDLSFKKGDIITVLKKTDSDNDWWTGMIGTRHGIFPSNYVKMKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GPH7</accession>
    <name>A0AAJ0GPH7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_421252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719529.1">
        <property type="nucleotide sequence ID" value="XM_062865556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GPH7"/>
    <dbReference type="GeneID" id="87884385"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042472140" evidence="1">
        <location>
            <begin position="19"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3303749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="120" mass="12128" checksum="3CEEFA2852E79024" modified="2024-07-24" version="1">MQLSLTAIVLGLAALASAMPQDERAVMARQNANRPVPSGTCCVANTSLKQDACTAANGQAGRCVPGGNNCGGALSCVQQSNLVCNNVVERGKSLCRAKAPGGGLFDGARIIQSLGQAKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQ25</accession>
    <name>A0AAJ0GQ25_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Gfo/Idh/MocA-like oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_285059</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719590.1">
        <property type="nucleotide sequence ID" value="XM_062863621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQ25"/>
    <dbReference type="GeneID" id="87882450"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055080">
        <property type="entry name" value="Gal80p-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051317">
        <property type="entry name" value="Gfo/Idh/MocA_oxidoreduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43708">
        <property type="entry name" value="CONSERVED EXPRESSED OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GALACTOSE_LACTOSE METABOLISM REGULATORY PROTEIN GAL80"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Gal80p_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
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    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="21"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Gal80p-like C-terminal" evidence="2">
        <location>
            <begin position="155"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3303810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="401" mass="43678" checksum="9590D6C878803531" modified="2024-07-24" version="1">MAPIRVALIGLSSPSSPQATTGWAASAHLPYLLSPRGRARYQIVGLLNSSVAAAEAAIKAYNLDADPNLNHHGVVRAYASPADLAADPEVDLVVCATRVDKHYATVIESLREGKDGFVEWPLAGDPERGRELAEEVRKHGGRSKGVVGLQGLKAPVVAVVRRLLAEGRIGRVVSSELRAFGGLGDRESLPVGWEYMTQREVGGNMVTIAFAHLFDMALSALGELKPGSLKGDLHLQRPENPLKDPTGAVVRTVRSDVPDLVFVAGKWQESDITQENATLHLRLRRGQPFPGDPCVVWTINGEKGEIRIVSQDMAFIQLGPPGESHVIEVHDFETDKVEKVEAAWADWQKELPFLARGVGALYEAIADARNKGTREDYVNFDTAVKRLETVHGLLEEWVHAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQC7</accession>
    <name>A0AAJ0GQC7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rab-GTPase-TBC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_494636</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719931.1">
        <property type="nucleotide sequence ID" value="XM_062867023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQC7"/>
    <dbReference type="GeneID" id="87885852"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000026">
        <property type="entry name" value="TBC (Tre-2/Bub2/Cdc16) domain family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000046">
        <property type="entry name" value="TBC domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="763"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="513"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1069"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="296"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="344"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="402"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3304151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1118" mass="120913" checksum="A0141BBBCA463C6A" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQH4</accession>
    <name>A0AAJ0GQH4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TBP-associated factor 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_512248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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                <person name="Haridas S."/>
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                <person name="Pangilinan J."/>
                <person name="Riley R."/>
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                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
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                <person name="Lalanne C."/>
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                <person name="Barry K."/>
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                <person name="Debuchy R."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 333.67</strain>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
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                <person name="Ng V."/>
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                <person name="Steindorff A."/>
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            <strain evidence="2">CBS 333.67</strain>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042614218" evidence="1">
        <location>
            <begin position="16"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3304424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="710" mass="79232" checksum="176A69734EA3E7CA" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQS7</accession>
    <name>A0AAJ0GQS7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_241433</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720212.1">
        <property type="nucleotide sequence ID" value="XM_062863067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQS7"/>
    <dbReference type="GeneID" id="87881896"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05339">
        <property type="entry name" value="17beta-HSDXI-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF736">
        <property type="entry name" value="RETINOL DEHYDROGENASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Ketoreductase" evidence="6">
        <location>
            <begin position="92"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3304432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="363" mass="39295" checksum="531CD35EBDAF07FE" modified="2024-07-24" version="1">MPPPYPTPPQRDSWFAPLSIDLIVKVFKTTFFHPFVAWIIPLCFRAQNMFWDAPPMLVSIGWASFITLCWIFGVINDRLAFGLPREVDLSEEVIVITGGASGLGLLIAEVYGMRGATVAVLDVEEMENGEARGVTYYKCDVTDKDQVARVAAEIERDLGTPTVLINNAAIVIGKPLLSLTFPEIEKSISTNLLSHFYTLKTFLPAMARSEVGGTIVTVSSVIGTVGAAQLTDYAAAKAGISALHRSLAAELRQSHPQIRTVLVTPGQLSTPLFYGVQTPNSFLAPVVEPVDVAKEVIAAIDAGRNAAIGMPLYARWIDWLNVLPLGLQAVARRLSGVDTAMKTFVGRKGAKKEGKGRVLIQGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQU8</accession>
    <name>A0AAJ0GQU8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_536532</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720232.1">
        <property type="nucleotide sequence ID" value="XM_062869557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQU8"/>
    <dbReference type="GeneID" id="87888386"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050052">
        <property type="entry name" value="ATP-dep_Clp_protease_ClpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48102:SF7">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX-LIKE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48102">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX-LIKE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="190"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Clp ATPase C-terminal" evidence="5">
        <location>
            <begin position="442"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="302"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3304452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="572" mass="64101" checksum="3376979BA011BDE0" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQW3</accession>
    <name>A0AAJ0GQW3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Pentafunctional AROM polypeptide</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="21">3-dehydroquinate synthase</fullName>
                <shortName evidence="21">DHQS</shortName>
                <ecNumber evidence="21">4.2.3.4</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="21">3-phosphoshikimate 1-carboxyvinyltransferase</fullName>
                <ecNumber evidence="21">2.5.1.19</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="21">5-enolpyruvylshikimate-3-phosphate synthase</fullName>
                <shortName evidence="21">EPSP synthase</shortName>
                <shortName evidence="21">EPSPS</shortName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="21">Shikimate kinase</fullName>
                <shortName evidence="21">SK</shortName>
                <ecNumber evidence="21">2.7.1.71</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="21">3-dehydroquinate dehydratase</fullName>
                <shortName evidence="21">3-dehydroquinase</shortName>
                <ecNumber evidence="21">4.2.1.10</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="21">Shikimate dehydrogenase</fullName>
                <ecNumber evidence="21">1.1.1.25</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="28" type="ORF">B0T15DRAFT_568316</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="28">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="28" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="28">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20 21 22">The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21 22">
            <text>3-dehydroquinate = 3-dehydroshikimate + H2O</text>
            <dbReference type="Rhea" id="RHEA:21096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="EC" id="4.2.1.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21256"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="EC" id="2.5.1.19"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:21257"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21 22">
            <text>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21968"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="EC" id="4.2.3.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19 21 22">
            <text>shikimate + ATP = 3-phosphoshikimate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13121"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.71"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21 22">
            <text>shikimate + NADP(+) = 3-dehydroshikimate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17737"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="21 22">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="21 22">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="21 22">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="21 22">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="21 22">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 21 22">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 21 22">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="21 22">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 21 22">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21 22">In the 2nd section; belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21 22">In the 3rd section; belongs to the shikimate kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21 22">In the 4th section; belongs to the type-I 3-dehydroquinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21 22">In the C-terminal section; belongs to the shikimate dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="22">In the N-terminal section; belongs to the dehydroquinate synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21">In the N-terminal section; belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="28">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.4" evidence="21"/>
    <dbReference type="EC" id="2.5.1.19" evidence="21"/>
    <dbReference type="EC" id="2.7.1.71" evidence="21"/>
    <dbReference type="EC" id="4.2.1.10" evidence="21"/>
    <dbReference type="EC" id="1.1.1.25" evidence="21"/>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720273.1">
        <property type="nucleotide sequence ID" value="XM_062870756.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87889585"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004765">
        <property type="term" value="F:shikimate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00502">
        <property type="entry name" value="DHQase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08195">
        <property type="entry name" value="DHQS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01556">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01065">
        <property type="entry name" value="NAD_bind_Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00464">
        <property type="entry name" value="SK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1090.10:FF:000007">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000135">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000015">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1970:FF:000007">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001256">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.65.10.10:FF:000007">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.65.10.10:FF:000008">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="entry name" value="Enolpyruvate transferase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00210">
        <property type="entry name" value="EPSP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03143">
        <property type="entry name" value="Pentafunct_AroM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00109">
        <property type="entry name" value="Shikimate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018508">
        <property type="entry name" value="3-dehydroquinate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016037">
        <property type="entry name" value="DHQ_synth_AroB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030960">
        <property type="entry name" value="DHQS/DOIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056179">
        <property type="entry name" value="DHQS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001381">
        <property type="entry name" value="DHquinase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006264">
        <property type="entry name" value="EPSP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023193">
        <property type="entry name" value="EPSP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008289">
        <property type="entry name" value="Pentafunct_AroM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041121">
        <property type="entry name" value="SDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010110">
        <property type="entry name" value="Shikimate_DH_AroM-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000623">
        <property type="entry name" value="Shikimate_kinase/TSH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023000">
        <property type="entry name" value="Shikimate_kinase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01356">
        <property type="entry name" value="aroA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01357">
        <property type="entry name" value="aroB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01093">
        <property type="entry name" value="aroD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01809">
        <property type="entry name" value="Shik-DH-AROM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090">
        <property type="entry name" value="AROM/DEHYDROQUINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090:SF5">
        <property type="entry name" value="PENTAFUNCTIONAL AROM POLYPEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01761">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24621">
        <property type="entry name" value="DHQS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01487">
        <property type="entry name" value="DHquinase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18317">
        <property type="entry name" value="SDH_C"/>
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            <begin position="77"/>
            <end position="189"/>
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            <begin position="191"/>
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            <begin position="405"/>
            <end position="831"/>
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            <begin position="1285"/>
            <end position="1365"/>
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        <location>
            <begin position="1541"/>
            <end position="1571"/>
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    <feature type="region of interest" description="3-dehydroquinate synthase" evidence="21">
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            <begin position="1"/>
            <end position="384"/>
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            <begin position="1280"/>
            <end position="1576"/>
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    <feature type="active site" description="Proton acceptor; for 3-dehydroquinate synthase activity" evidence="21">
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            <position position="260"/>
        </location>
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    <feature type="active site" description="Proton acceptor; for 3-dehydroquinate synthase activity" evidence="21">
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            <position position="275"/>
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    <feature type="active site" description="For EPSP synthase activity" evidence="21">
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            <position position="819"/>
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    <feature type="active site" description="Proton acceptor; for 3-dehydroquinate dehydratase activity" evidence="21">
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            <position position="1170"/>
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            <position position="1198"/>
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            <name>Zn(2+)</name>
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            <name>Zn(2+)</name>
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        <ligand>
            <name>ATP</name>
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        <source>
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        <source>
            <dbReference type="PIRNR" id="PIRNR000514"/>
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        <source>
            <dbReference type="Pfam" id="PF00275"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01761"/>
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        <source>
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        <source>
            <dbReference type="Pfam" id="PF24621"/>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
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    <sequence length="1576" mass="170276" checksum="5426550B8E723889" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GRE6</accession>
    <name>A0AAJ0GRE6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">40S ribosomal protein S5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_400076</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_062720496.1">
        <property type="nucleotide sequence ID" value="XM_062865040.1"/>
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    <dbReference type="GeneID" id="87883869"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14867">
        <property type="entry name" value="uS7_Eukaryote"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.455.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="entry name" value="Ribosomal protein S7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_uS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_uS7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_uS7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_uS7_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005716">
        <property type="entry name" value="Ribosomal_uS7_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003106">
        <property type="entry name" value="PRK04027.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01028">
        <property type="entry name" value="uS7_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="Ribosomal protein S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS7" evidence="5">
        <location>
            <begin position="54"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3304716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="212" mass="23570" checksum="7D17AE7653997642" modified="2024-07-24" version="1">MSEGEVEVASSSYEVLPKEVLAEVGSVKLFNRWSYEDVEIRDISLTDYIQIRSPVYLPHSAGRYAAKRFRKANCPIIERLTNSLMMHGRNNGKKLMAVRIVAHAFEIIHLMTDQNPIQIAVDAIVNCGPREDSTRIGSAGTVRRQAVDVSPLRRVNQAIALLTTGAREASFRNVKSIAECLAEELINAAKGSSNSYAIKKKDELERVAKSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GRJ5</accession>
    <name>A0AAJ0GRJ5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_558808</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720576.1">
        <property type="nucleotide sequence ID" value="XM_062870486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GRJ5"/>
    <dbReference type="GeneID" id="87889315"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3304796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="32169" checksum="B73A69DA6AF1C1B6" modified="2024-07-24" version="1">MQQPPLHQPLHLKPHAFVNKLVKVSVRVLEEERVRVDEVLGDKEGTWAYELWLYMAMAVWAFDRLLRLGRALKHGVRRAQVTDLGNGYMRVDIRGNHPFSIIPTPSIPKPGLACSSKDEESQKGTTPVVKVESSPEDRPSVGITLFIKLSTGLTKRLRAHGGLLTLLDGPYSNSHAGPVLRCDKVLFIGGGIGITGVVPWAFQHRNVKLVWSVAESARCLTDAIDLTGVADSEVRVGRRFDVDELVNGEAGAGWERAGVVVSGPGSLCDDVRAAVAVAGSRGNTVFEFEVDAYSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GRN2</accession>
    <name>A0AAJ0GRN2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Beta-xylanase</fullName>
            <ecNumber evidence="9">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0T15DRAFT_255393</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16 9">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="9"/>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720677.1">
        <property type="nucleotide sequence ID" value="XM_062863238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GRN2"/>
    <dbReference type="GeneID" id="87882067"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044846">
        <property type="entry name" value="GH10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490:SF76">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00134">
        <property type="entry name" value="GLHYDRLASE10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00633">
        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042494413" description="Beta-xylanase" evidence="11">
        <location>
            <begin position="18"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="12">
        <location>
            <begin position="17"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="GH10" evidence="13">
        <location>
            <begin position="82"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="60"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3304897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="388" mass="41508" checksum="2F7E287FE82E138B" modified="2024-07-24" version="1">MHSLAFLLAVGPAAVLAQSPLWGQCGGQGWTGPTTCAAGSVCQKSNDWYSQCVPGTASSSAAPAPAETSKTTGSAPAPTGGSGAADGLNNKFKAKGKLYFGTEIDHYHLNNQPLISIVKKDFGQLTCENSMKWDAIEPNRNQFNFANADAVVNFAQANGKLMRGHTLLWHSQLPQWVQNINDRNTLTQVIQNHVTTMVTRYKGKILQWDVVNEIFAEDGSLRDSVFSRVLGEDFVGIAFRAARAADPAAKLYINDFNLDIANYAKLTRGMVEHVNKWVAQGIPIDGIGSQSHLAAPGGWNAASGAPAALKALAAANVKEIAITELDIAGAAANDYTTVVNACLQIQKCVGITVWGVSDKDSWRSSENPLLFDRNYQPKAAYNALSNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GRN4</accession>
    <name>A0AAJ0GRN4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_398894</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720622.1">
        <property type="nucleotide sequence ID" value="XM_062864977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GRN4"/>
    <dbReference type="GeneID" id="87883806"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3304842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="250" mass="28097" checksum="7969F27301BE6DC1" modified="2024-07-24" version="1" fragment="single">DSQAFLILMLIIHGCNRQVPRLVSLELLAKIAALVDYYQCLEAVEVFAGLWLQRLRSQRQLPEQVGRDLILWLFISWVFANGDIFTSVTTIALRQSQGPLPTLGLPIPEKIIEAIDRRRQEVVEKVTTALHGLCVSFRDSPDQCCFECSSIQLGALTKEMHAKRLEPRPASPMLGYSVVATIDTARSFRSPQWDCKRRGYRYASRYCDLESIIRSKVDGLKEMIRGLKLGDFQERRSPVASDGLGATAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GS34</accession>
    <name>A0AAJ0GS34_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">EXS family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_397817</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720871.1">
        <property type="nucleotide sequence ID" value="XM_062864924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GS34"/>
    <dbReference type="GeneID" id="87883753"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000822">
        <property type="term" value="F:inositol hexakisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016036">
        <property type="term" value="P:cellular response to phosphate starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004342">
        <property type="entry name" value="EXS_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783:SF103">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 53 MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783">
        <property type="entry name" value="XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03124">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51380">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="EXS" evidence="5">
        <location>
            <begin position="38"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3305091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="241" mass="27924" checksum="2A91693B92DEC1F8" modified="2024-07-24" version="1" fragment="single">PVEFRDVFLREAWCSLTYTTSNIELLFCLYTSSWHDADYCNSSHSRLLEFFALPPTLRAIQCIRSCYDTRNIFPHLFNFGKYTMTLLSAVSLSLYRIEDLQTKLSFFVTFAAMNAVCCCNYPTLDVFVDFSLVRGRPSQKLLRDITALRPIWIYYVTMLADPILRFSWVFYGIFTHNTQYGILVSFIVSLCEVVRRGLWALLRVENEHCTSIIQVQILARCSGPSPRSGSWPRPRTFAQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GSG9</accession>
    <name>A0AAJ0GSG9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_484939</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721072.1">
        <property type="nucleotide sequence ID" value="XM_062866258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GSG9"/>
    <dbReference type="GeneID" id="87885087"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="46"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="579"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="614"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3305292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="634" mass="71788" checksum="9F0CF99EF9130204" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GSN7</accession>
    <name>A0AAJ0GSN7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_555133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720980.1">
        <property type="nucleotide sequence ID" value="XM_062870379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GSN7"/>
    <dbReference type="GeneID" id="87889208"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="596"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="259"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3305200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="678" mass="72775" checksum="1F3E84B2652F69BE" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GSW1</accession>
    <name>A0AAJ0GSW1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carbon-nitrogen hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_532595</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721307.1">
        <property type="nucleotide sequence ID" value="XM_062869319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GSW1"/>
    <dbReference type="GeneID" id="87888148"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07564">
        <property type="entry name" value="nitrilases_CHs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.110.10:FF:000042">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044149">
        <property type="entry name" value="Nitrilases_CHs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044:SF1">
        <property type="entry name" value="CN HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044">
        <property type="entry name" value="NITRILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="3">
        <location>
            <begin position="8"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="329"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="333"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3305527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="353" mass="38475" checksum="7EFCB66D0B2B186A" modified="2024-07-24" version="1">MATKETKFKVAAAHAAPVFMNKAETLKKVVSLIEQAGDQDIKLLVFPETFVPGYPYWIECYPPLKQVDALAKYAEESVVVEPNNEDIAPVQDACRSAGVAISLGVSERVAGGHTLFNTQVTIDSDGTILGVHRKLQPTYVERLVWAQGGGATLKNFPLSSLGGRNLGGLACWEHTMNGARQALITQGQHIHAGAWPALSTMSGFEEVADAQIEALMKTHALTAQVFVVTASNYVDAGCLSWMTENLGEQEFIKAGGGWSSVLHPFCAYLAGPHTGAEERLVAAEVDFGQLGHVKVWIDAAGHYQRPEILQFDFDFRPLWADEKANRFGRRKGMKEAPQESKDGEKPCRLNLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GT11</accession>
    <name>A0AAJ0GT11_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_532892</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721388.1">
        <property type="nucleotide sequence ID" value="XM_062869334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GT11"/>
    <dbReference type="GeneID" id="87888163"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00106">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000072">
        <property type="entry name" value="Kinesin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF15">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="8">
        <location>
            <begin position="2"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="406"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="490"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="591"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="406"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="614"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="637"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="90"/>
            <end position="97"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3305608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="744" mass="81772" checksum="4D3BCB0EBDFAE08D" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GU66</accession>
    <name>A0AAJ0GU66_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_222339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3306238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722018.1">
        <property type="nucleotide sequence ID" value="XM_062862827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GU66"/>
    <dbReference type="GeneID" id="87881656"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042560916" description="Secreted protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3306238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="71" mass="7956" checksum="C3EA8387A99E65C4" modified="2024-07-24" version="1">MNRWCLHLLTFRCLWADQAFHGLVPRPAKALVCGVNKGNRSDATPGRCALLTGQLYCKQSDHQRMSADNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GUN4</accession>
    <name>A0AAJ0GUN4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_509865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722273.1">
        <property type="nucleotide sequence ID" value="XM_062867821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GUN4"/>
    <dbReference type="GeneID" id="87886650"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="397"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3306493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="423" mass="46314" checksum="849FD7FF16F4DE8E" modified="2024-07-24" version="1">MLSLLATRPADRHLCRALLLFSSFVTIVLLIGFLPMVRKQAQEPFEIPLDVCEAVCGSGVALSSDWAERIMSWVWPVVFLTSSIAISPFGLETNFLMATHALANPIDTFYSIFRTISYWERIEQETSIHANQLGQQSLISIGEGTAEQFKHCLILILHAMDTLSAIIPENYPRRPFSDFIRQVTQQEPRLVFSVGNALRCHRRRSSGYGPVVVAAISLFFALTGLGGSGVSGGKIAAGFIFTWLLPLTLLRCQIGDWHNLHGIHLQLQRLVLEVGKKNKPWVDVEDTTFLDPPDLDVAVLAQNGILPTFQHSGDRPGERRIYCLLLSFCPVLLSFCTAFGALLAPQTTSFTDRHWLVIGIAGLLIGNTCASGIFLASQRARKGASRGPSSATLYGDCTIAAVILGVLVSSATGLLNSCRTWSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GV49</accession>
    <name>A0AAJ0GV49_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rab-GTPase-TBC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_431376</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722409.1">
        <property type="nucleotide sequence ID" value="XM_062865733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GV49"/>
    <dbReference type="GeneID" id="87884562"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000060">
        <property type="entry name" value="TBC domain protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1310:FF:000001">
        <property type="entry name" value="TBC1 domain family, member 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045913">
        <property type="entry name" value="TBC20/Gyp8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20913:SF7">
        <property type="entry name" value="RE60063P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20913">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 20/GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="65"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="342"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3306629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="429" mass="48467" checksum="C4E71DDA8782C8E9" modified="2024-07-24" version="1">MDGEKGMPSPTDTGSQSMEPSRDKKTANHSNTTSTADKKKEELLEACRRRDLSALRALAESRGGFLADSIRQQAWPILLGLPPGNDVKTEAESPSSSWESLPRHKDEDQVQLDVNRAFIYYPDNQTESQLAHQKSLLSQLIVSVLRQHPYLCYFQGYHDIAQVLLLVLPSSVQLPAVTHLSLSHIRDFMLPSLSPAIAQLRLIPDILRLSDPPLWRHLSHTEPFFALSGTLTMYAHDITSLGEIARLFDVLLAREPVFTVYLFAAIVRSRRDELFDTPPDEPEMLHSILSKLPVPLDLEGLIAAALRLQKEVPPEQLPAWKRISRWSVLKTNHSSNSRGGDGRGGGGGGGEQRVEQWRMYFERQVEELRWEEKKERARKWVWKHRRPARMVALAVLVGVLAVWLRKGPLPGPLVSGMGYLSGLLARWWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GV80</accession>
    <name>A0AAJ0GV80_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_150353</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722479.1">
        <property type="nucleotide sequence ID" value="XM_062861986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GV80"/>
    <dbReference type="GeneID" id="87880815"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000117">
        <property type="entry name" value="MFS hexose transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF29">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14500)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="39"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3306699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="528" mass="59932" checksum="B9910241145A670D" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GVE0</accession>
    <name>A0AAJ0GVE0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein S21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_152126</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722544.1">
        <property type="nucleotide sequence ID" value="XM_062862009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GVE0"/>
    <dbReference type="GeneID" id="87880838"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070124">
        <property type="term" value="P:mitochondrial translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052837">
        <property type="entry name" value="Mitoribosomal_bS21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001911">
        <property type="entry name" value="Ribosomal_bS21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41237">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN MRP21, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41237:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS21M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01165">
        <property type="entry name" value="Ribosomal_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="52"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="102"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="119"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3306764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="266" mass="29832" checksum="56B0C3FDD2709F1F" modified="2024-07-24" version="1">MEFRQVVHSVCRSAAGASRPSLASPRLPQGILVQHRQFTANNKQRLEALAMAPPQSQDPLPIRHTPSSASRHRSLPPRPAPIRKSNFYMDPVTAKKARSPWATQAAANQTQTDNAQTQPQSQATTLTGTAPSSTLSIEDVFSIPGQIQADMEAATAGTAGNSLTNWDEDIFLKNHHYTTEPELRLRPSTGRTININKGSVDLARGFRLLQKAVNQNGIKRDLIMQRAHERPALKRKRQKRERWQQRFQSSFRATMNRVFELKAQGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GVW2</accession>
    <name>A0AAJ0GVW2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Profilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_492597</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the profilin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_062866868.1"/>
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        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
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    </dbReference>
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        <property type="entry name" value="PFN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005455">
        <property type="entry name" value="PFN_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036140">
        <property type="entry name" value="PFN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027310">
        <property type="entry name" value="Profilin_CS"/>
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    <dbReference type="PANTHER" id="PTHR11604">
        <property type="entry name" value="PROFILIN"/>
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    </dbReference>
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        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROFILIN"/>
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        <property type="entry name" value="PROFILINPLNT"/>
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        <property type="entry name" value="PROF"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
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        <source>
            <dbReference type="RuleBase" id="RU003908"/>
        </source>
    </evidence>
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            <dbReference type="RuleBase" id="RU003909"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3307101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="135" mass="14434" checksum="9CC700E3AA566A57" modified="2024-07-24" version="1">MSWQAYVDTSLVGSGHIDKAVIVSAAGDSTWAATEGFSVGADELKNLISILNEQDKKDGPAVIKAYSDGIHVAGERYVATRIEDRHVYGRHGKTGICVVKTGQAILITHYGENAQAGNATQTVESLADYLIKHGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GW25</accession>
    <name>A0AAJ0GW25_9PEZI</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_393260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722695.1">
        <property type="nucleotide sequence ID" value="XM_062864678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GW25"/>
    <dbReference type="GeneID" id="87883507"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
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        <location>
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            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3306915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="524" mass="57263" checksum="8BBB636B86FFCD2A" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GWA3</accession>
    <name>A0AAJ0GWA3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SAC3/GANP/Nin1/mts3/eIF-3 p25 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_393448</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723091.1">
        <property type="nucleotide sequence ID" value="XM_062864686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GWA3"/>
    <dbReference type="GeneID" id="87883515"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.990:FF:000006">
        <property type="entry name" value="Putative SAC3/GANP domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045107">
        <property type="entry name" value="SAC3/GANP/THP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005062">
        <property type="entry name" value="SAC3/GANP/THP3_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436">
        <property type="entry name" value="80 KDA MCM3-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436:SF4">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03399">
        <property type="entry name" value="SAC3_GANP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="273"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3307311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="527" mass="59616" checksum="54228EA0436177FD" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GWF7</accession>
    <name>A0AAJ0GWF7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mono-functional DNA-alkylating methyl methanesulfonate N-term-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_174163</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723114.1">
        <property type="nucleotide sequence ID" value="XM_062862228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GWF7"/>
    <dbReference type="GeneID" id="87881057"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101908">
        <property type="entry name" value="Putative isomerase YbhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="4">
        <location>
            <begin position="12"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="5">
        <location>
            <begin position="437"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="3">
        <location>
            <begin position="792"/>
            <end position="1145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3307334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1176" mass="130205" checksum="791A173E1ABD5F39" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GWJ2</accession>
    <name>A0AAJ0GWJ2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NUC153 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_177065</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723172.1">
        <property type="nucleotide sequence ID" value="XM_062862254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GWJ2"/>
    <dbReference type="GeneID" id="87881083"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039754">
        <property type="entry name" value="Esf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012580">
        <property type="entry name" value="NUC153"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056750">
        <property type="entry name" value="RRM_ESF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12202">
        <property type="entry name" value="ESF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12202:SF0">
        <property type="entry name" value="ESF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08159">
        <property type="entry name" value="NUC153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25121">
        <property type="entry name" value="RRM_ESF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ESF1 RRM" evidence="7">
        <location>
            <begin position="178"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="NUC153" evidence="6">
        <location>
            <begin position="635"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="80"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="224"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="411"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="646"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="109"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="244"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="427"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="490"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="502"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="512"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="552"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="571"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="591"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="616"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3307392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="717" mass="81198" checksum="9AC670BCBD44F2A1" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GWK0</accession>
    <name>A0AAJ0GWK0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B0T15DRAFT_530137</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the glycosyl hydrolase 18 family. Chitinase class III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723187.1">
        <property type="nucleotide sequence ID" value="XM_062869155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GWK0"/>
    <dbReference type="GeneID" id="87887984"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02877">
        <property type="entry name" value="GH18_hevamine_XipI_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045321">
        <property type="entry name" value="Cts1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050542">
        <property type="entry name" value="Glycosyl_Hydrlase18_Chitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708:SF49">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="5" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="10 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 13 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042562281" description="chitinase" evidence="14">
        <location>
            <begin position="24"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="16">
        <location>
            <begin position="31"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="15">
        <location>
            <begin position="366"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK3307407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="402" mass="42520" checksum="9A53303E2602CDF9" modified="2024-07-24" version="1">MFATPLSAAAFWGYLFALPGVLAGFSSTSPSNIAVYWGQNSINKVEASGGQRRLATYCTNTPVNIIPLAFLNGIKNPTLVNFANAGDNCTAFAGTQLLSCPQIEEDIKACQSQGKTILLSIGGATYTEGGFSSASEAQKWADTLWAMFGPKQSSSSALRPFGAASVDGFDMDFESVTSNMAPFAARLRSNMDSAAASSGRKYYLSGAPQCPFPDAAQRDMLEQVPFDFVSVQFYNNYCGATAYPANFNFDTWDNWARNSAPNRNVKILLGLPGGPTGAGSGYVSGDQLKQVIQYSRGFPSFGGVMAWDMSQVYANPGWLDSVVSALGGTLPPVTTTATSKPTSTPTTTLVTVTRTTSSGPNSPTGSAVPQWGQCGGIGYTGPTQCQAPYTCKYVSDWWSQCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GWT7</accession>
    <name>A0AAJ0GWT7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MoaB/Mog domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_395211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723377.1">
        <property type="nucleotide sequence ID" value="XM_062864768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GWT7"/>
    <dbReference type="GeneID" id="87883597"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047884">
        <property type="term" value="F:FAD diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042726">
        <property type="term" value="P:flavin-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00885">
        <property type="entry name" value="cinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="entry name" value="MoaB/Mog-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056596">
        <property type="entry name" value="FLAD1_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47675">
        <property type="entry name" value="MOLYBDOPTERIN BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47675:SF1">
        <property type="entry name" value="MOLYBDOPTERIN BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24102">
        <property type="entry name" value="FLAD1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="Molybdenum cofactor biosynthesis proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoaB/Mog" evidence="1">
        <location>
            <begin position="57"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3307597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="340" mass="37618" checksum="1831FB2B196F66CD" modified="2024-07-24" version="1">MFSRLSQVARHLARPLPNLAHSSAATTASSQIATVNRIMTTGPTAAERASRKIHTAACLIIGDEVLGGKAGRDFQWTWLITLGQTNSHYFAKWCFGLGINLKRIEVIADDETEIIEAVRRMSERYDLIVTSGGIGPTHDDITYKSIAKAFGLPLVLHKEAYDLMKKLSKPRPNQPPFNWDQDSPALRAKLRMVELPTDASRPLEEQFLFPCNDLWVPVAVVNGNVHILPGVPKLFEKLLDGLTPSILPRLTDPEGKGIVRVIISTPLPESEVAEYLTALAERVEPKGVKVGSYPRWGKKRNTVTLVGRDKAYLESIAPEVVHYVQGRLVTVEGEDDEADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GXB3</accession>
    <name>A0AAJ0GXB3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chaperonin 10-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_182947</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723355.1">
        <property type="nucleotide sequence ID" value="XM_062862332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GXB3"/>
    <dbReference type="GeneID" id="87881161"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF7">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="9">
        <location>
            <begin position="30"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3307575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="436" mass="46135" checksum="19E34E7FB1B7FEDD" modified="2024-07-24" version="1">MAPSAMGEPAPMHLPAASKASTINASVLHGPRDLRMETRTIEEPGIGELQIAVHTTGICGSDVSYYKKFANGDLCACMPLSLGHESSGTVVAIGAQVTGFSIGDRVALEVGIPCGQCGICRQGRYNLCKRMRFRSSAKSVPHFQGTLQERINHPAAWCHKLPDNISFDAAALLEPLSVAIHAVNRARPTPGSTALVIGAGAVGLLTAAMARQSGCSVVTIADVDQGRVDFAIAKGFATHGFVVPRPLHTCSSSSSMYSGSSSGTSTPLDGVMTPGSTYSFQSQLDYAKTLAADMLGLTSTSNPLLVDDEDDGVDVTFECTGKEVCMHTSLYATRPGGKVIMVGMGTPIQTLPMSVAHLREIDILGIFRYANTYATGIRILCAREKTPSAAGYIIPNLDDMVTHRFKGLENARRAFELASRTVDDEGNLVLKVVIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GXS9</accession>
    <name>A0AAJ0GXS9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Frag1/DRAM/Sfk1 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_523597</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723903.1">
        <property type="nucleotide sequence ID" value="XM_062868702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GXS9"/>
    <dbReference type="GeneID" id="87887531"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050911">
        <property type="entry name" value="DRAM/TMEM150_Autophagy_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324:SF2">
        <property type="entry name" value="EG:22E5.9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324">
        <property type="entry name" value="FASTING-INDUCIBLE INTEGRAL MEMBRANE PROTEIN TM6P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="7">
        <location>
            <begin position="6"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="240"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="246"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3308123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="304" mass="34440" checksum="7C69592054847B81" modified="2024-07-24" version="1">MIRLSYWITPVFGGIVWLATLLALLLYWIVSADRTHYSSMSEGQTIAYISDVGASNLKPLFIAGCCITTVLLDLSFGFDRWLRHRGRLAPNTTTGEKILSGLTIVFAIVGTVGLILLSIFDTARYPKQHDIFLLLFIAGYVLSAIFICWEYWRLGKTHRETRILRYSFYVKVIFIIIEVVLAIAFIASNFTKHYNPAAILEWVIAFIFSAYVFSFYIDLYPAAANKQQLEVSKGAGGHGLHMRLTRGREREREKPRRYDAAGEMEEGGSERTLRGSNGVASFEGDRVQHGRRSRSRSRVMASNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GXT9</accession>
    <name>A0AAJ0GXT9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tryptophan--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Tryptophanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0T15DRAFT_523542</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="3"/>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723879.1">
        <property type="nucleotide sequence ID" value="XM_062868693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GXT9"/>
    <dbReference type="GeneID" id="87887522"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000003">
        <property type="entry name" value="Tryptophan--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000033">
        <property type="entry name" value="tryptophan--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055:SF1">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055">
        <property type="entry name" value="TRYPTOPHANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="464"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="444"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="464"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3308099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="489" mass="55273" checksum="07D240EB64220D78" modified="2024-07-24" version="1">MATHVNAAALSESPVPQDAQPKQQTKQTVDPYNVQGEVDENGVVQAIDYNKLVEDFGTKKIDDELLARFERVTGKRPHHFLRRGIVFSHRDFELILDRYERGEPFFLYTGRGPSSDSVHVGHTIPFEFTKWLQDTFDVPLIIMLTDDEKYLFSEKRTIEEVQGYCNSNAKDIIAIGFDPAKTFIFSDFDYVGGAFYRNVVRLSKHITLNQARAIFGFNDSTNIGRIHFGSIQGATSWASSFPHIFGDNEAETVGIPALIPCAIDQDPYFRMTRDVSARLKYQGKQYAKPSLIHALFLPALQGPGTKMSASIDESAIFMRDTPNQIKNKINRYAFSGGRVSQEEHRQFGGDTSVDVAFQYLRFFLEDDDELERIRVAYEKGEMLTGELKAICIEQLQKYVAGFQERRAKVDDETVKLFMERRPLKWGGNPRAPIVVPKVENGEAGEAKEDGEGKMTKNQLKKLEKMRQAEAKKAQKKAEKAEQAAAKATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GY84</accession>
    <name>A0AAJ0GY84_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_106485</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724146.1">
        <property type="nucleotide sequence ID" value="XM_062861432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GY84"/>
    <dbReference type="GeneID" id="87880261"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000009">
        <property type="entry name" value="MFS multidrug transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="QUINIDINE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS_1"/>
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    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
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    </dbReference>
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    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="62"/>
            <end position="82"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">Uncharacterized protein</fullName>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
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    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
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                <person name="Cros-Aarteil S."/>
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="KAK3308499.1"/>
        </source>
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        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
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                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
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                <person name="Ament-Velasquez S.L."/>
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                <person name="Powell A.J."/>
                <person name="Barry K."/>
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                <person name="Grigoriev I.V."/>
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                <person name="Hiltunen Thoren M."/>
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            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAK3309186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062866172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GZT3"/>
    <dbReference type="GeneID" id="87885001"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="94"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="58"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="163"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="424"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="490"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="953"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1009"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1026"/>
            <end position="1038"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3309186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1047" mass="114380" checksum="A5603DD0873075A6" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H0F6</accession>
    <name>A0AAJ0H0F6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Oxysterol-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_515770</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725327.1">
        <property type="nucleotide sequence ID" value="XM_062868220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H0F6"/>
    <dbReference type="GeneID" id="87887049"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000007">
        <property type="entry name" value="Oxysterol binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3490:FF:000020">
        <property type="entry name" value="Oxysterol binding protein (Osh7), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2720:FF:000001">
        <property type="entry name" value="Oxysterol-binding OBPalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF102">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="428"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="462"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="487"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="504"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="532"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3309547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="542" mass="60814" checksum="21512AE487FF0DD3" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H0J5</accession>
    <name>A0AAJ0H0J5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-hydroxyisobutyrate dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_134126</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17681"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57700"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-valine degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.31" evidence="3"/>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3309220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725000.1">
        <property type="nucleotide sequence ID" value="XM_062861787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H0J5"/>
    <dbReference type="GeneID" id="87880616"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008442">
        <property type="term" value="F:3-hydroxyisobutyrate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000006">
        <property type="entry name" value="3-hydroxyisobutyrate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981:SF81">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0101">Branched-chain amino acid catabolism</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="9">
        <location>
            <begin position="14"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="10">
        <location>
            <begin position="192"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3309220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="339" mass="35148" checksum="E60B3D7082AD5924" modified="2024-07-24" version="1">MASTASTDALPESVGFIGLGAMGKPMAANLAKALPRGSQLHVHDAALAQVQELWTSFPDVVVRCWSAQEVAEASDVVITMLPEGAHVKSVYLDPTTGVIAALSSSPSRPKLFIDSSTIDTASSLHVKQELSAVSATASFYDAPVSGGVLGAENGTIAFFLGCSPSDRNIARLNALLQTMGAKVVPCGGPSLGLAAKLSNNYLSGIITIACAEAMDMGMRAGIDARVLAAVFAAGTAQNTICDVFNPVPGVCGRAPSSNGYRGGFRVQLMRKDIGLAVDMARTVGARNVLGASGLGVYVAASAAADCRDLDSRVVYRYLGGRENWEHDQEEQIAKAGETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H0Q8</accession>
    <name>A0AAJ0H0Q8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nascent polypeptide-associated complex subunit alpha-like UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_506429</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725462.1">
        <property type="nucleotide sequence ID" value="XM_062867577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H0Q8"/>
    <dbReference type="GeneID" id="87886406"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14361">
        <property type="entry name" value="UBA_HYPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052617">
        <property type="entry name" value="Huntingtin-int_K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038922">
        <property type="entry name" value="HYPK_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044034">
        <property type="entry name" value="NAC-like_UBA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31184:SF2">
        <property type="entry name" value="HUNTINGTIN-INTERACTING PROTEIN K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31184">
        <property type="entry name" value="HUNTINGTIN-INTERACTING PROTEIN K FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19026">
        <property type="entry name" value="UBA_HYPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nascent polypeptide-associated complex subunit alpha-like UBA" evidence="2">
        <location>
            <begin position="80"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3309682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="124" mass="13095" checksum="E6C48E6616296C65" modified="2024-07-24" version="1">MAEDRQPADIVEGATSGDVEDEVQSTAKSAEDRKAAAALSKLDARGDDEAAPGREVDQEAVKNAMNALGGSTDKKETKKVKVDAADVTLLVEELELPKAKVTELLKAHDGDAVKAMKAYIQPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H0X7</accession>
    <name>A0AAJ0H0X7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Sorting nexin-4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Autophagy-related protein 24</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B0T15DRAFT_388666</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725290.1">
        <property type="nucleotide sequence ID" value="XM_062864453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H0X7"/>
    <dbReference type="GeneID" id="87883282"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07628">
        <property type="entry name" value="BAR_Atg24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06863">
        <property type="entry name" value="PX_Atg24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000035">
        <property type="entry name" value="Sorting nexin-4 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000042">
        <property type="entry name" value="Vacuolar targeting protein Atg24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45949">
        <property type="entry name" value="SORTING NEXIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45949:SF2">
        <property type="entry name" value="SORTING NEXIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0072">Autophagy</keyword>
    <keyword evidence="9 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="10" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="16">
        <location>
            <begin position="63"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="409"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00040748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00041273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK3309510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="490" mass="54926" checksum="C82F6A307BB51F81" modified="2024-07-24" version="1">MAVLDQDNFSNISWHSEQNQDAAGPSTSTSHDRNHDPEYAKSRSDVDRSGDEGPDHGHTGGEILECVVSEAHKENDGTKDAYVSYLITTNTTFPTFQRSTASVRRRFTDFVFLYKVLIRDYQGCAVPPLPDKQRMEYVRGDRFGPDFTSRRAYSLQRFLTRLALHPILRRASILHTFLESPDWNATMRSQKERLGPAGAGGDGFGQVSQAPAGGSGGVFDSIADSFMNAFTKVHKPDRRFIEVKERSDKLDEDLNHVEKVVSRVARREADLETDLRDLAEQFQKLITLEPGVESAVHAFAASVEDTAAGLKQLRDHTDQDYLGSLRDMTAYSAALKNLLKAREQKQLDYEQLTEYLNRATADRDMLASGHGHSTGSFGSGALSGAGGFIRSKIEDVRGVDHEQARRDRQRKLELRIDELTGAVETARAEAENFADQVVREVESFEWIKRVEFKRQFGGLVNAHIDFYGGVIDVWERYVKEMEKEGVVGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H1N5</accession>
    <name>A0AAJ0H1N5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_375087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725645.1">
        <property type="nucleotide sequence ID" value="XM_062864224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H1N5"/>
    <dbReference type="GeneID" id="87883053"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF6">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3309865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="406" mass="46640" checksum="800526A378989D6A" modified="2024-07-24" version="1" fragment="single">FPRLPAELRLRIWYLSLKRQRMIKVAVWTEWTEDWAKSSDQSKSRYFMARNHLGKLVSGGSYSTQILHPNRPALFSPLLWVTCESRQAALGFYRVHLPTSIQGRSSCGNKTEELVLYFNPEHDIVDIEDWSLSGAGLVDFLHDARAYDRKGRGVTHLALDMYGTCPGHSRLPSPTTIHPVAAVSFAEILQYTLRTVLQPVPCNGPFRIQPTVDGDKSHFAQTMPLHANQRWDRFGTGNIRWLETDPRWGVEHDLGAVSFRRNPLTCLWSWEDMERAFGIAERVPDDKFRFYLCPYIHWPAPQSYYDAVHDKSTVLPPRQNNPFLKSPWREKLAAYLHVEQEHWLRRTRQEEIPRHGSLVDAETFQRMESVPSTALGMWLCSPEAFGNSDNPAGKVFDLSASRPGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H1T0</accession>
    <name>A0AAJ0H1T0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0T15DRAFT_386532</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725740.1">
        <property type="nucleotide sequence ID" value="XM_062864329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H1T0"/>
    <dbReference type="GeneID" id="87883158"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05586">
        <property type="entry name" value="STKc_Sck1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000008">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000116">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="C2" evidence="12">
        <location>
            <begin position="290"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="495"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="14">
        <location>
            <begin position="757"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="92"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="139"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="253"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="361"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="842"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="142"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="161"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="262"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="277"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="380"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="524"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3309960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="897" mass="98550" checksum="D08CEE6B56E56BBC" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H1V2</accession>
    <name>A0AAJ0H1V2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-chaperonin molecular chaperone ATPase</fullName>
            <ecNumber evidence="2">3.6.4.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_425546</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.10" evidence="2"/>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726018.1">
        <property type="nucleotide sequence ID" value="XM_062865634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H1V2"/>
    <dbReference type="GeneID" id="87884463"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd24093">
        <property type="entry name" value="ASKHA_NBD_HSP70_Ssb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000014">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000004">
        <property type="entry name" value="Heat shock protein SSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000005">
        <property type="entry name" value="Heat shock protein ssb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3310238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="614" mass="66894" checksum="F599BAE57E331C3F" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H2I2</accession>
    <name>A0AAJ0H2I2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_489312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726426.1">
        <property type="nucleotide sequence ID" value="XM_062866585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H2I2"/>
    <dbReference type="GeneID" id="87885414"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="9"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3310646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="187" mass="20269" checksum="1778663147D0CFD6" modified="2024-07-24" version="1">MASYDIAQYLLDRANIQDTVTKNSLYYDTRNISGLANEVYAASILIDYTSILGGEPTTLSRTEWLEQAQGILQTFESSQHLISGIIIDLPQPAPASSSGGTTTTTTTTMATRPEKASLMAHVGGNMILKGQPSSNVIQNGGILEAELQRDPELEKQGVNPWRITKYKVIKKWGNGPGDKVLASELQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H355</accession>
    <name>A0AAJ0H355_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoribosylaminoimidazole-succinocarboxamide synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_519734</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726652.1">
        <property type="nucleotide sequence ID" value="XM_062868449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H355"/>
    <dbReference type="GeneID" id="87887278"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021840">
        <property type="entry name" value="DUF3433"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544">
        <property type="entry name" value="SPRAY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11915">
        <property type="entry name" value="DUF3433"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="473"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="513"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="589"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="626"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3310872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="751" mass="83778" checksum="84A0D79282273660" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H371</accession>
    <name>A0AAJ0H371_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0T15DRAFT_547429</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Vacuole membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ATG22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726440.1">
        <property type="nucleotide sequence ID" value="XM_062870174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H371"/>
    <dbReference type="GeneID" id="87889003"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032974">
        <property type="term" value="P:amino acid transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17483">
        <property type="entry name" value="MFS_Atg22_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044738">
        <property type="entry name" value="Atg22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050495">
        <property type="entry name" value="ATG22/LtaA_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATG22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <keyword evidence="4 10" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
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            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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            <end position="475"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="487"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="526"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="557"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="586"/>
            <end position="607"/>
        </location>
    </feature>
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            <begin position="34"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="631"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="631"/>
            <end position="643"/>
        </location>
    </feature>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3310660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="654" mass="71613" checksum="2E37B71C23C353CD" modified="2024-07-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H383</accession>
    <name>A0AAJ0H383_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_58554</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726771.1">
        <property type="nucleotide sequence ID" value="XM_062871094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H383"/>
    <dbReference type="GeneID" id="87889923"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22749">
        <property type="entry name" value="Otubain_C65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.60">
        <property type="entry name" value="Peptidase C65 Otubain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.20">
        <property type="entry name" value="Peptidase C65 Otubain, subdomain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019400">
        <property type="entry name" value="Peptidase_C65_otubain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042468">
        <property type="entry name" value="Peptidase_C65_otubain_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042467">
        <property type="entry name" value="Peptidase_C65_otubain_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12931:SF15">
        <property type="entry name" value="UBIQUITIN THIOESTERASE OTUBAIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12931">
        <property type="entry name" value="UBIQUITIN THIOLESTERASE PROTEIN OTUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10275">
        <property type="entry name" value="Peptidase_C65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="OTU" evidence="8">
        <location>
            <begin position="173"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="533"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3310991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="555" mass="60913" checksum="7F6063D1ABD62C5B" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LXS8</accession>
    <name>A0AAJ0LXS8_9PEZI</name>
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        <recommendedName>
            <fullName evidence="2">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_317339</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717389.1">
        <property type="nucleotide sequence ID" value="XM_062864013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LXS8"/>
    <dbReference type="GeneID" id="87882842"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="199"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3301609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="346" mass="36240" checksum="51454C4AD6B96A11" modified="2024-07-24" version="1">MVSNGDSSGKVAADFERIIQEARDRKKNEALAAKIFGKNQRASTPVSKPAPAAAGSLASRAGVKKRPVPDKGARHNTGDIDGEWTHDLHDTQSRGARTSGSGAGSLAARITDANAPPTGPASQRRKPRQRRAAQVAEALIRSELRSERQGHPQQPQPQQQTSFTNAAIPTAPKAMTTAAAFNRGITIRGLAGPFVVMAQNFAPGTTAADIESAMTPVGGIITSCRIVKTHPIVIAEIVFESKEGADNVIATFNNQTADGRVLSVYPKVGNTPAAKLPAQPTSDNDMVVDGSYGFDDPMDTDPAAGRLPPTGPAAGVSSSGLYSDSLVKRNRWGRGFSRGARGFGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LXU3</accession>
    <name>A0AAJ0LXU3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0T15DRAFT_487831</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717373.1">
        <property type="nucleotide sequence ID" value="XM_062866462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LXU3"/>
    <dbReference type="GeneID" id="87885291"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07843">
        <property type="entry name" value="STKc_CDC2L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000054">
        <property type="entry name" value="Cyclin-dependent kinase 11B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000211">
        <property type="entry name" value="Cyclin-dependent kinase G-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045267">
        <property type="entry name" value="CDK11/PITSLRE_STKc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF107">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 11A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="111"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="22"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="407"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="22"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3301593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="473" mass="52822" checksum="7874D16D12562219" modified="2024-07-24" version="1">MASKAKSRWTDDETDAVLEAQLKKEKEEKKRLKAEKARRLEEERQAREAAAAAAAQQEGDGTQGPPAKRRKVSQEPDARQPAGTSDTSVNAPRLLRFEGGAFGTCRSVENYDKLNDIEEGAYGWVSRAKEIATGRVVALKRLKIDPKDRGGLPVTGLREIQILKDCDHRNVVKLREVVVGDDTSKIENIFLVLEFVEHDLKSILEDMPEPFLASEVKTLLQQLASGVAYLHDNWILHRDLKTSNLLLNNRGQLKIADFGMARYVGDPPPKLTQLVVTLWYRAPELLLGATRYSAAIDMWSIGCIFGELLTREPLLQGRNEVDELTKIFELCGIPTEETWPSFRRLPNARGLRLPSNSNKSAMTGSVIRAKFPLLTSAGVALLNGLLSLDPDKRPTAKEMLAHEYFKQDPKPKQEAMFPTFPSKAGQERRRRRETPNAPARGQEAVEIGAVDFSGIFSGREREERGGGFSLRMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LYF7</accession>
    <name>A0AAJ0LYF7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_296874</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718003.1">
        <property type="nucleotide sequence ID" value="XM_062863773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LYF7"/>
    <dbReference type="GeneID" id="87882602"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF11">
        <property type="entry name" value="WSC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042528728" description="WSC domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="3">
        <location>
            <begin position="508"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="610"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="615"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3302223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="635" mass="66883" checksum="07E9976BADA3ADC2" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LYR0</accession>
    <name>A0AAJ0LYR0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phox homologous domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_543307</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718365.1">
        <property type="nucleotide sequence ID" value="XM_062869982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LYR0"/>
    <dbReference type="GeneID" id="87888811"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06897">
        <property type="entry name" value="PX_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000052">
        <property type="entry name" value="Putative SNARE complex subunit (Vam7)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775:SF3">
        <property type="entry name" value="SORTING NEXIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="2">
        <location>
            <begin position="5"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="1">
        <location>
            <begin position="306"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3302585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="368" mass="40404" checksum="DBAFFEE253F9D398" modified="2024-07-24" version="1">MAPPLEISIPTTSLHTPADGSKPYTLYNITLRLPLRSFVVQKRYSDFVALHNALTSLVGSPPPEPLPSKSWFRSTVSSPALTEQRRVGLERYLRAIAEPPDRRWRDTPAWRAFLNLPSGAGASVSGVSVDGRAQPVAGTRDATLAAASDPARWVDLREELRELLKEANWVLSQNQDAKEPAERRAAAAKARMALLKAGNLLLVLKEGLNSMKKDGRLGEGEFVRRKDFLDVASKQRDDFERIVSDFAVKGLSGGGGSASGVASESDRAKLGVTGARRPVGRTIGRPLPETERTRELDNTGVLQMQKEDMREQDERVNEIGSTVQRLKTHAIAINDEITYQLGQLDLAKEGADSLERKLAVANRRAKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZ54</accession>
    <name>A0AAJ0LZ54_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">B0T15DRAFT_262743</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718856.1">
        <property type="nucleotide sequence ID" value="XM_062863359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZ54"/>
    <dbReference type="GeneID" id="87882188"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990604">
        <property type="term" value="C:IRE1-TRAF2-ASK1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070059">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036498">
        <property type="term" value="P:IRE1-mediated unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09769">
        <property type="entry name" value="Luminal_IRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10422">
        <property type="entry name" value="RNase_Ire1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000077">
        <property type="entry name" value="Putative Serine/threonine-protein kinase/endoribonuclease IRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000572">
        <property type="entry name" value="Serine/threonine-protein kinase/endoribonuclease IRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.180:FF:000002">
        <property type="entry name" value="Serine/threonine-protein kinase/endoribonuclease IRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.180">
        <property type="entry name" value="KEN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045133">
        <property type="entry name" value="IRE1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010513">
        <property type="entry name" value="KEN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038357">
        <property type="entry name" value="KEN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_b-propeller_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954">
        <property type="entry name" value="IRE1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954:SF6">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06479">
        <property type="entry name" value="Ribonuc_2-5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00580">
        <property type="entry name" value="PUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51392">
        <property type="entry name" value="KEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8 21" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042499115" description="non-specific serine/threonine protein kinase" evidence="21">
        <location>
            <begin position="34"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="22">
        <location>
            <begin position="775"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="domain" description="KEN" evidence="23">
        <location>
            <begin position="1077"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="506"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="641"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="20">
        <location>
            <begin position="696"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="724"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="803"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KAK3303076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1216" mass="135005" checksum="20D61802A89BAFE0" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZ81</accession>
    <name>A0AAJ0LZ81_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Feruloyl esterase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_420113</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718931.1">
        <property type="nucleotide sequence ID" value="XM_062865535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZ81"/>
    <dbReference type="GeneID" id="87884364"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3303151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="370" mass="41590" checksum="539E71B4CCF3F1EA" modified="2024-07-24" version="1">MTANENESSDAPRGPPTTVADVLTLVITTSPTPSAPATELLSHIIASFREHCPKLTECSVILVLDTYDHISTTARLKKGHVTAEGASTYAEYKENAKRLILQEYAPSCSHHTGRDLVVDYGEAEFGSTAYAQQTNAVPLTITRTHDGRIVFIEPSQRLGFGLAVRSALRLTRTPYVWIQQHDWTLVSEVPLCPLLEIMQKQSKTAGSANADDSDTVQVPIKYVCFPSVRMVEYARSDHVMLFPALRAVTYLHKQNFTIRSGDGSITKIPLTPLFFWHDKPHLAETEHYLAKVFPNRAAVPRGAFIEDTIGHRARAEMKDGQWKKWACWLYYPDEGKRLCMRHLKGRTWRGAEGELAQKLEYMRLNQAVPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZI9</accession>
    <name>A0AAJ0LZI9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleic acid-binding, OB-fold protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_274991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719219.1">
        <property type="nucleotide sequence ID" value="XM_062863502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZI9"/>
    <dbReference type="GeneID" id="87882331"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3303439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="357" mass="39381" checksum="95F741A0F4E7F9C6" modified="2024-07-24" version="1">MSSKVLIFTGAPESNVLDWSSSGLLSEFQDAIAWFARINTTTPLRLAASSTPEYAVWRSLSLDKAYLPTGFSQQHAIPFGDTARDSVFGPSPEFLTPTSLTFTLTGEDGDRTLSQFYEHSMIAHQGISSSQLISQSSEQAASFLSDGTTSWSGDGTQEGPVKEPLVFRGSDLLSDLRNIPSASYLVKIQPQTMTSNLIVGIISISRPRAVKTRWGATKHLVEVLVGDETKAGFAITYWLPSDSVANSALAGLRPRDIVLMQNVALNVFANKVYGCSLSRNLTKVHLLYRLRLDSQDVQGYYSTSDLSSTGSVHPQLEKTRRVRDWVVDFVGRGSQDRNNTRTRHRWDRPPLDDTQVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZK8</accession>
    <name>A0AAJ0LZK8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_504632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719188.1">
        <property type="nucleotide sequence ID" value="XM_062867504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZK8"/>
    <dbReference type="GeneID" id="87886333"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3303408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="377" mass="41913" checksum="6B18A4B8A8973735" modified="2024-07-24" version="1">MFRIQLNGRRTARAVVRGMKAWHFARHTVAEVVVVHSRVEETHADPKAGKNLYKTRTVRLYFSWGRPARNQVEVEDVRVVQDEKNGEFLDRRKTVKRRTPYTLREVSLDRDSKPYWTAPKYMLDEFVNRVRGRPGSGAWVTTADSMVLATMVDLAYKSYLKTATPRTVDFHVPGPVSPNSVENTVSSSSASARPGHRSGLSGQQNELQSHVTSRSRKQVQSVNWGPVAPPILSYRPVRTSRDKLKCTPVSLGPVSIGPSILRACDTLSARSLLSYRPVPTSRDSLKCTPVSSGSAGMGWPIFRGRDDFRPSDCLCSDGSTQSEECLRFRSGTSFRSGDYLRPSDYFQSGTIFQSGAVFQSDAVFQSGSSLRSASNPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZL5</accession>
    <name>A0AAJ0LZL5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Vacuolar protein sorting-associated protein 27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B0T15DRAFT_540566</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 12">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Endosome membrane</location>
            <topology evidence="2 12">Peripheral membrane protein</topology>
            <orientation evidence="2 12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the VPS27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719336.1">
        <property type="nucleotide sequence ID" value="XM_062869796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZL5"/>
    <dbReference type="GeneID" id="87888625"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033565">
        <property type="term" value="C:ESCRT-0 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15735">
        <property type="entry name" value="FYVE_spVPS27p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21385">
        <property type="entry name" value="GAT_Vps27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16979">
        <property type="entry name" value="VHS_Vps27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1940:FF:000001">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000031">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000161">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017073">
        <property type="entry name" value="HGS/VPS27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049425">
        <property type="entry name" value="Vps27_GAT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47794">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47794:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02809">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21356">
        <property type="entry name" value="Vps27_GAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036956">
        <property type="entry name" value="Hrs_Vps27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0967">Endosome</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="VHS" evidence="16">
        <location>
            <begin position="26"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="15">
        <location>
            <begin position="168"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="230"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="290"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="461"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="464"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="477"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="504"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="566"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="594"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="610"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="634"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="647"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="682"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR036956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK3303556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="729" mass="79364" checksum="574BAE6630DAE62E" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M0L1</accession>
    <name>A0AAJ0M0L1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Histone H2A.Z-specific chaperone CHZ1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_245998</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Forms a chaperone-bound H2A.Z-H2B complex that acts as a source for SWR1 complex-dependent H2A to H2A.Z histone replacement in chromatin.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Forms a heterotrimer with H2A.Z-H2B, stabilizing the association of the histone dimer. Also, with a lower affinity, forms a heterotrimer with H2A-H2B.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CHZ1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720344.1">
        <property type="nucleotide sequence ID" value="XM_062863123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M0L1"/>
    <dbReference type="GeneID" id="87881952"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019098">
        <property type="entry name" value="Histone_chaperone_domain_CHZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09649">
        <property type="entry name" value="CHZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01082">
        <property type="entry name" value="CHZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone chaperone" evidence="8">
        <location>
            <begin position="65"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="37"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3304564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="121" mass="13158" checksum="9980E79876EFA529" modified="2024-07-24" version="1">MAGENGTNDSMAVTNPENGAATATDLKGKGKAPATEEPVEDTSMAEDDDDDDDEEDDDVPEEAEAPDEDNMEEIDLDNVIGRRTRGKVIDFAKAAAENPADDDEDEDDEDFEVEDEKMDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M118</accession>
    <name>A0AAJ0M118_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycoside hydrolase, family 16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_400662</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720718.1">
        <property type="nucleotide sequence ID" value="XM_062865075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M118"/>
    <dbReference type="GeneID" id="87883904"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00413">
        <property type="entry name" value="Glyco_hydrolase_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38121">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38121:SF5">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042466492" evidence="2">
        <location>
            <begin position="19"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="3">
        <location>
            <begin position="32"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3304938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="364" mass="38699" checksum="2D01156605FF135A" modified="2024-07-24" version="1">MKLLSCSVLSFLTVLAVAATDSCNCGFTSTVNDQSVLFTEAFETDFRHVADLKPSEWRPQMYNKTAAASHGPYGRLYSNATTLPNTVGSDAGLQLVVSSAIVDTLVPCAEVAAKRRDFFYGTYRVGMKLSNESGTCAAFYWYFNDTQEIDIEFLSKDFNPSNNSYPVNIVLHSPLSLATGFDAVKAGTWTVAYLPFNPAEGFHEYRFDFVQAAVYFYADGTYLAEMKGLAVPTTGGKLLLAHWSNGKAAWSGGPPKQDSVMTVQYVKAYFNSSEPGVVEAAQDRCDAHGMTCAIPGMTEAKDLDSGAAFFNLTSANGGSGSAGGSGSGESTSTSRSGGGENSRSTRGLGSLLTASLMAGFLLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M130</accession>
    <name>A0AAJ0M130_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyclin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_554911</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720866.1">
        <property type="nucleotide sequence ID" value="XM_062870369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M130"/>
    <dbReference type="GeneID" id="87889198"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF10">
        <property type="entry name" value="PHO85 CYCLIN-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0195">Cyclin</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="2">
        <location>
            <begin position="70"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3305086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="197" mass="21737" checksum="2265A40E9271257C" modified="2024-07-24" version="1">MMDSLPKLSPAELNAAALERFVAQPVDEEMIRYLAKAATGLTGHGVLAGADETLPTVAGRVGRGLPTIERFIMQLVVSSNVPVPTLMSSLVYLRRLKPRVQPMAKGLRQTHRIFLASLILAAKYLNDKSLKNADWAAYSVIRTQAYSFGFSKTEVNVMESQLLSLLDWDLGISDEDLYLELDYFLAPIRADIQPGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M180</accession>
    <name>A0AAJ0M180_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Choline/carnitine acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_502366</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721004.1">
        <property type="nucleotide sequence ID" value="XM_062867432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M180"/>
    <dbReference type="GeneID" id="87886261"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008458">
        <property type="term" value="F:carnitine O-octanoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF67">
        <property type="entry name" value="PEROXISOMAL CARNITINE O-OCTANOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="849"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="883"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="6">
        <location>
            <begin position="32"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3305224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="953" mass="106703" checksum="0F4AFD7B223F150D" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M1P2</accession>
    <name>A0AAJ0M1P2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_533121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAK3305687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062869343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M1P2"/>
    <dbReference type="GeneID" id="87888172"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042593829" description="Secreted protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3305687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="81" mass="8746" checksum="6BCB2002409E8F24" modified="2024-07-24" version="1">MVRQLPAPILVLLLRVAVVGLKADDELCLITAGEESVRRDIDLSSVAPTRELSIALTMFGFPLQLVASKFLLTTTSLTSYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M1R2</accession>
    <name>A0AAJ0M1R2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">G protein-coupled glucose receptor regulating Gpa2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_556238</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721575.1">
        <property type="nucleotide sequence ID" value="XM_062870413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M1R2"/>
    <dbReference type="GeneID" id="87889242"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GCR1-cAMP_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023041">
        <property type="entry name" value="Glucose_rcpt_Git3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022596">
        <property type="entry name" value="GPR1/2/3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11710">
        <property type="entry name" value="Git3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11970">
        <property type="entry name" value="GPR_Gpa2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02001">
        <property type="entry name" value="GCR1CAMPR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="7">
        <location>
            <begin position="22"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="8">
        <location>
            <begin position="36"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="215"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3305795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="355" mass="39375" checksum="43395FA012CD6511" modified="2024-07-24" version="1">MFDIAPRAALAAPTDPGIIRVQSAVILVASILACVGAGWIMASFMAFSNLRTFRHHLIFGLAISDCVMALNFLVSSSMNVGGRWIGAPENARFCSFNGFMTQVFVIQTDYWVLTIAICTYFVLADHKRSSSWVQDHLPVIWALPWLLSITWAAIGLGVTGYGDIGAWCWFTSDEVRLLVNFVPRWVIVAAMFLMYARLYFLLFRAHRHMASLEASGSLSGSGSRQLDTNGHTSSQPEMSGNTSRHTRKLKKLARLMLLYPLAYSVIWSLPTTIRIYQTITGEPAPWQIQTLDKACIVVQGFVDAVIYGATESSLSSWRNLFFPRKFPILNGNDGTVAPATTYGDGLDKARGTRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M1Z3</accession>
    <name>A0AAJ0M1Z3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0T15DRAFT_485440</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="3"/>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721723.1">
        <property type="nucleotide sequence ID" value="XM_062866289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M1Z3"/>
    <dbReference type="GeneID" id="87885118"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06602">
        <property type="entry name" value="GH31_MGAM_SI_GAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030458">
        <property type="entry name" value="Glyco_hydro_31_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF95">
        <property type="entry name" value="ALPHA_BETA-GLUCOSIDASE AGDC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00129">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042609137" description="alpha-glucosidase" evidence="8">
        <location>
            <begin position="18"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="10">
        <location>
            <begin position="96"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="9">
        <location>
            <begin position="265"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="11">
        <location>
            <begin position="660"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="443"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3305943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="852" mass="95151" checksum="D08793A3A2796861" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M2L6</accession>
    <name>A0AAJ0M2L6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_431547</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722502.1">
        <property type="nucleotide sequence ID" value="XM_062865736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M2L6"/>
    <dbReference type="GeneID" id="87884565"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="beta-trefoil_Ricin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14200">
        <property type="entry name" value="RicinB_lectin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042581685" description="Ricin B lectin domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="2">
        <location>
            <begin position="61"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3306722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="169" mass="18092" checksum="9959DADA76BF4F6D" modified="2024-07-24" version="1">MLSTSILLITLAATGLAQTAAPEGYRKVYITSNVNPKFVVVPKAATSGSTVVVKTLNNKPEQQWYIKDGTSKIQLVDSTLCLDGGAQNNWRDMGNIYVNTCADGVASQNWLVIGDGRIALEPTNKKQCIDLQYMRATENNPVGLYNCAGLGNTGAADKGINWPLVNVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M2S9</accession>
    <name>A0AAJ0M2S9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rhodanese-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_147926</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722414.1">
        <property type="nucleotide sequence ID" value="XM_062861955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M2S9"/>
    <dbReference type="GeneID" id="87880784"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01519">
        <property type="entry name" value="RHOD_HSP67B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE RDL2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086:SF10">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE_RHODANESE-LIKE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="106"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3306634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="208" mass="22527" checksum="48FF9BFD20B22974" modified="2024-07-24" version="1">MASTRAGVSLVQASALSLRAASSVRVNAAAQLPLRQYHNHTAGPHRAVRLPQQSSPACASGPSSPLRQNSSQFAASRARYSTDAESLSKPNKIWDFESLQKATSTPNPSVTIIDVREPHELQESGRIPGALNIPVASAPDSFHISDEEFEDRFGYPRPAPDAEVVFYCRAGVRSRAAAGLAREAGWKNVGEYPGSWLDWFEKGGKVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M2X1</accession>
    <name>A0AAJ0M2X1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Iron-sulfur cluster biogenesis chaperone, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0T15DRAFT_432082</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for the assembly of iron-sulfur (Fe/S) clusters in mitochondria. Assisted by the DnaJ-like co-chaperone jac1 and the nucleotide exchange factor mge1, it mediates ATP-dependent Fe-S cluster transfer from the scaffold proteins isu1/isu2 to grx5.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722743.1">
        <property type="nucleotide sequence ID" value="XM_062865747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M2X1"/>
    <dbReference type="GeneID" id="87884576"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11733">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000014">
        <property type="entry name" value="Chaperone protein DnaK HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000020">
        <property type="entry name" value="Chaperone protein HscA homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000007">
        <property type="entry name" value="Heat shock protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000004">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000003">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003520">
        <property type="entry name" value="PRK05183.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0346">Stress response</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="646"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="662"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3306963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="671" mass="73127" checksum="11C331B2D63C4833" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M319</accession>
    <name>A0AAJ0M319_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_157068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722684.1">
        <property type="nucleotide sequence ID" value="XM_062862070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M319"/>
    <dbReference type="GeneID" id="87880899"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="526"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="710"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="757"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3306904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="798" mass="89073" checksum="D7EE41FB54797E8D" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M369</accession>
    <name>A0AAJ0M369_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 15">Amino-acid acetyltransferase, mitochondrial</fullName>
            <ecNumber evidence="5 15">2.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 15">Glutamate N-acetyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13 15">N-acetylglutamate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B0T15DRAFT_566668</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 15">N-acetylglutamate synthase involved in arginine biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>L-glutamate + acetyl-CoA = N-acetyl-L-glutamate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.1" evidence="5 15"/>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722834.1">
        <property type="nucleotide sequence ID" value="XM_062870701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M369"/>
    <dbReference type="GeneID" id="87889530"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004042">
        <property type="term" value="F:L-glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006592">
        <property type="term" value="P:ornithine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04266">
        <property type="entry name" value="DUF619-NAGS-FABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000049">
        <property type="entry name" value="Amino-acid acetyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011190">
        <property type="entry name" value="GlcNAc_Synth_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006855">
        <property type="entry name" value="Vertebrate-like_GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342:SF4">
        <property type="entry name" value="AMINO-ACID ACETYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342">
        <property type="entry name" value="N-ACETYLGLUTAMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04768">
        <property type="entry name" value="NAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007892">
        <property type="entry name" value="NAGS_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51731">
        <property type="entry name" value="GNAT_NAGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="16">
        <location>
            <begin position="448"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR007892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK3307054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="625" mass="68820" checksum="B92264D355CB4678" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M3H4</accession>
    <name>A0AAJ0M3H4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_174985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        </source>
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        </source>
    </evidence>
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                <person name="Kuo A."/>
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                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
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                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
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                <person name="Ament-Velasquez S.L."/>
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                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
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                <person name="Grigoriev I.V."/>
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                <person name="Gladieux P."/>
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    </reference>
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        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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</entry>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
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                <person name="Kuo A."/>
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                <person name="LaButti K."/>
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                <person name="Ng V."/>
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                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
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                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
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                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
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                <person name="Hiltunen Thoren M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
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                <person name="Cros-Aarteil S."/>
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
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                <person name="Ament-Velasquez S.L."/>
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                <person name="Grigoriev I.V."/>
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                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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</entry>
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    </protein>
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    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Kuo A."/>
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                <person name="Riley R."/>
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                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
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                <person name="Daum C."/>
                <person name="Ng V."/>
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                <person name="Ament-Velasquez S.L."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724272.1">
        <property type="nucleotide sequence ID" value="XM_062864578.1"/>
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    <dbReference type="GeneID" id="87883407"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18604">
        <property type="entry name" value="ABC_6TM_VMR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000825">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF353">
        <property type="entry name" value="ABC TRANSPORTER ATP-BINDING PROTEIN_PERMEASE VMR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="496"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="525"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="603"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1031"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1113"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1188"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1216"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="326"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="703"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="1035"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1394"/>
            <end position="1670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="448"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="951"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1693"/>
            <end position="1735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="962"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1693"/>
            <end position="1702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1709"/>
            <end position="1724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3308492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1735" mass="190720" checksum="4D35B4B054D32F44" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M4B6</accession>
    <name>A0AAJ0M4B6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glutamate--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Glutamyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B0T15DRAFT_508980</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Glu) + L-glutamate + ATP = L-glutamyl-tRNA(Glu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="3"/>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724303.1">
        <property type="nucleotide sequence ID" value="XM_062867760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M4B6"/>
    <dbReference type="GeneID" id="87886589"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017102">
        <property type="term" value="C:methionyl glutamyl tRNA synthetase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1160.10:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.800.10:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000037">
        <property type="entry name" value="Glutamine--tRNA ligase cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.10:FF:000004">
        <property type="entry name" value="Glutamyl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000036">
        <property type="entry name" value="Putative glutamyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1160.10">
        <property type="entry name" value="Glutamyl-trna Synthetase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.800.10">
        <property type="entry name" value="Glutamyl-tRNA Synthetase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="entry name" value="Ribosomal Protein L25, Chain P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02076">
        <property type="entry name" value="Glu_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050132">
        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004526">
        <property type="entry name" value="Glu-tRNA-synth_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020061">
        <property type="entry name" value="Glu_tRNA_lig_a-bdl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_bL25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049437">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00463">
        <property type="entry name" value="gltX_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF5">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20974">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13 17" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="14">
        <location>
            <begin position="121"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding" evidence="15">
        <location>
            <begin position="429"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA synthetases class I (E and Q) anti-codon binding" evidence="16">
        <location>
            <begin position="533"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF20974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK3308523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="638" mass="72913" checksum="814580A10E24A419" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M4R0</accession>
    <name>A0AAJ0M4R0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar-sorting protein SNF7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Vacuolar protein-sorting-associated protein 32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_391683</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724753.1">
        <property type="nucleotide sequence ID" value="XM_062864600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M4R0"/>
    <dbReference type="GeneID" id="87883429"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF10">
        <property type="entry name" value="GH13992P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3308973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="224" mass="25230" checksum="3A7FBDA11722D7E4" modified="2024-07-24" version="1">MSGIWGWFGGGAAQKRKETPKNVILDLRTNMEMLQKREAHLSRQIEEQDQIARKNVNTNKTAAKAALRRKKIHEHNLEQTLNHIATIEQQMNAIESANIHQETFMAMERAGKAMATIHGKLTPAKVDETMDKLQEYNRLNEEIAEAIGSVALGQQVDDTELEDELEQLQQQELEDKMLETGPLPVDNIQRLPAVANGEIKGKAPAVTEDDEEAELRKLQAEMAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M4Z0</accession>
    <name>A0AAJ0M4Z0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Signal recognition particle 54 kDa protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0T15DRAFT_134847</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Signal-recognition-particle (SRP) assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum (ER) membrane. SRP is required for the cotranslational protein translocation for ER import and preferentially recognizes strongly hydrophobic signal sequences. It is involved in targeting the nascent chain-ribosome (RNC) complex to the ER and is proposed to participate in the arrest of nascent chain elongation during membrane targeting. SRP54 binds to the signal sequence of presecretory protein when they emerge from the ribosomes. SRP54 interacts with the scR1 RNA and mediates the association of the resulting SRP-RNC complex with the signal recognition particle receptor (SR) via its alpha subunit SRP101. Both, SRP54 and SRP101, are locked in their GTP bound forms in the SRP-RNC-SR complex, which dissociates upon transferring the signal sequence to the protein-conducting channel (translocon). After signal sequence transfer, SRP54 and SRP101 act as reciprocal GTPase-activating proteins (GAPs), thereby resolving their association.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Fungal signal recognition particle consists of a 7S RNA molecule (scR1) and at least six protein subunits: srp72, srp68, srp54, sec65, srp21 and srp14.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The M domain binds the 7SL RNA and the signal sequence of presecretory proteins.</text>
    </comment>
    <comment type="domain">
        <text evidence="13">The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which binds GTP and forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the SRP receptor subunit srp101. The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another. SRP receptor compaction upon binding with cargo-loaded SRP and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3309242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725022.1">
        <property type="nucleotide sequence ID" value="XM_062861798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M4Z0"/>
    <dbReference type="GeneID" id="87880627"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006616">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17875">
        <property type="entry name" value="SRP54_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.30:FF:000003">
        <property type="entry name" value="Signal recognition particle 54 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000022">
        <property type="entry name" value="Signal recognition particle 54 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="entry name" value="Signal recognition particle, SRP54 subunit, M-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006325">
        <property type="entry name" value="SRP54_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01425">
        <property type="entry name" value="SRP54_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 54K PROTEIN SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF5">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="Signal peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10 13" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="14">
        <location>
            <begin position="269"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3309242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="527" mass="56994" checksum="1E00D992A2D4C62C" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M5F6</accession>
    <name>A0AAJ0M5F6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_481344</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725576.1">
        <property type="nucleotide sequence ID" value="XM_062866020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M5F6"/>
    <dbReference type="GeneID" id="87884849"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12611">
        <property type="entry name" value="RRM1_NGR1_NAM8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12613">
        <property type="entry name" value="RRM2_NGR1_NAM8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12346">
        <property type="entry name" value="RRM3_NGR1_NAM8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000065">
        <property type="entry name" value="mRNA binding post-transcriptional regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000227">
        <property type="entry name" value="mRNA binding post-transcriptional regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000159">
        <property type="entry name" value="tRNA selenocysteine 1-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050825">
        <property type="entry name" value="RBM42_RBP45_47-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640:SF10">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="42"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="135"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="271"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="340"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="368"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="378"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="390"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3309796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="403" mass="43054" checksum="5CB9FE11C4496F27" modified="2024-07-24" version="1">MADYTVAGPSSAATNGNNMNGSGDSGFSQTAPMSTTSNEAAKTLWMGEMEGWMDENFIKNVFQTVCSENVQVKVIRDRTSGNAGYCFVEFSTPEAAQKALNLNGNQVPGSSRVFKLNWASGGGLVDRRDDRGPEYSIFVGDLGPEVNEYVLVSLFQSRFPSCKSAKIMTDAMTGQSRGYGFVRFSDEGDQQRALIEMQGVYCGNRPMRISTATPKTRSHGGYGQAHGGANPMMQAMPGPGAMWGVPGPYYGQGAFNHPMQPMNQFTDPNNTTVFVGGLSGYVTEDELRSFFQGFGEITYVKIPPGKGCGFVQFVHRHAAEMAINQMQGYPIGNSRVRLSWGRSQNNSGVGTPYRPAPPPPHYQMAPGGMPPHPPHGPAGPGGPYGGPPFGGNPPQGPPPGPMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M5Y5</accession>
    <name>A0AAJ0M5Y5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_498295</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725909.1">
        <property type="nucleotide sequence ID" value="XM_062867309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M5Y5"/>
    <dbReference type="GeneID" id="87886138"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010961">
        <property type="term" value="P:intracellular magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12829">
        <property type="entry name" value="Alr1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000008">
        <property type="entry name" value="CorA family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000014">
        <property type="entry name" value="CorA family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044089">
        <property type="entry name" value="Alr1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535">
        <property type="entry name" value="MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535:SF51">
        <property type="entry name" value="MANGANESE RESISTANCE PROTEIN MNR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="776"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="376"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="111"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="230"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="386"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="433"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3310129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="804" mass="91482" checksum="8758181B7553FD81" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M606</accession>
    <name>A0AAJ0M606_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_517677</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725969.1">
        <property type="nucleotide sequence ID" value="XM_062868320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M606"/>
    <dbReference type="GeneID" id="87887149"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043335">
        <property type="term" value="P:protein unfolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19499">
        <property type="entry name" value="RecA-like_ClpB_Hsp104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000120">
        <property type="entry name" value="ATP-dependent chaperone ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000025">
        <property type="entry name" value="ATP-dependent Clp protease subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000010">
        <property type="entry name" value="Chaperone clpB 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050130">
        <property type="entry name" value="ClpA_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638:SF176">
        <property type="entry name" value="HEAT SHOCK PROTEIN 78, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="125"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="523"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="Clp ATPase C-terminal" evidence="9">
        <location>
            <begin position="701"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="338"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3310189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="806" mass="89309" checksum="CFF54FAEE400D2A6" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M694</accession>
    <name>A0AAJ0M694_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_507096</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726195.1">
        <property type="nucleotide sequence ID" value="XM_062867627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M694"/>
    <dbReference type="GeneID" id="87886456"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3310415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="443" mass="47691" checksum="1BDAA7759F739F8A" modified="2024-07-24" version="1">MGASVSTLVGWTVVIGCIYIVAFGLPGKKKARDAGRGAAQRQRVEDKPHSQTRKEPKEKAKRQRSEAYSKDADEASKPSQLKQRAAKPSGPSQPADYSSDDDVDNREFARQLASVKQGTSLNAPKKSDEKRHKSVKQSRAQIIDDEKAEPSKMSAPSSTAGVDADDDESSTPSPEIKAVDAGDVSDMLEPKAAGPSVLRLTETDKAKPKKEKKAKAPEKAETKKQRQNRQKAEAAKALREENEKQRRADLEAQRRQARIAEGRPAKDGSAFVAAQNQQSAWNRNGTDGSVSSSATNGGFLPVQPLDTFDTSSYTDASVSKSESATTPAQTNPADSWIASLPSEEEQMEMLRGEEAWNTVTSKKPNKKKHREAMADSPVDSEPTVIQAAPSQPKPRAMSNGTGAVAAPATSKTAGKTTKPFSQQSSFAALSPSEDETGENEWEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M6B1</accession>
    <name>A0AAJ0M6B1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase S54 rhomboid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_518474</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726192.1">
        <property type="nucleotide sequence ID" value="XM_062868362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M6B1"/>
    <dbReference type="GeneID" id="87887191"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050925">
        <property type="entry name" value="Rhomboid_protease_S54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731:SF14">
        <property type="entry name" value="PRESENILIN-ASSOCIATED RHOMBOID-LIKE PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731">
        <property type="entry name" value="RHOMBOID PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="407"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="431"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="524"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="9">
        <location>
            <begin position="396"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="259"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="259"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3310412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="565" mass="62094" checksum="EC99317CD572EE34" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M6G0</accession>
    <name>A0AAJ0M6G0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PQ loop repeat-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_51939</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-histidine(out) + L-arginine(in) = L-histidine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71063"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the laat-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726626.1">
        <property type="nucleotide sequence ID" value="XM_062868427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M6G0"/>
    <dbReference type="GeneID" id="87887256"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098852">
        <property type="term" value="C:lytic vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034486">
        <property type="term" value="P:vacuolar transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000009">
        <property type="entry name" value="PQ loop repeat family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000012">
        <property type="entry name" value="Vacuolar membrane PQ loop repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF44">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="330"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="112"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3310846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="370" mass="40102" checksum="68C7A9F1B14DFCA3" modified="2024-07-24" version="1">MLGFVIAVPEALKSLGVGEALSGVFGSISLTAWICLLLPQLITNYKAKSADALSMKFLLIWLLGDIANLSGALFTSLAPSTIALACYFCMADLILISQCTYYNTINARRRAARRERHLHHPSQHHHRRRPSTTADPLDVSTSSAVIDDVPPSETDPLLHHDDHTTHHRPRSDSGGLPGSHRRHGIRRHSSSGLVDPLTRIITGEDDTPDSNPWLHNALSLVAVWVVGAAGWFVSFKMGAWDVGGGAGGEPVPGDDGGSGEQVMKHPVAMVGMVLGYASAVCYLCARIPQIIKNYREKSCEGLALLFFLLSLTGNFTYGASVIAYSQESDYIVRALPWLLGSLGTMVEDCIIFVQFRIYSPKRQVKAGGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M6I3</accession>
    <name>A0AAJ0M6I3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Crossover junction endonuclease MUS81</fullName>
            <ecNumber evidence="14">3.1.22.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B0T15DRAFT_44019</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts with EME1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the XPF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.22.-" evidence="14"/>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726402.1">
        <property type="nucleotide sequence ID" value="XM_062865903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M6I3"/>
    <dbReference type="GeneID" id="87884732"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048476">
        <property type="term" value="C:Holliday junction resolvase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048257">
        <property type="term" value="F:3'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21036">
        <property type="entry name" value="WH_MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20074">
        <property type="entry name" value="XPF_nuclease_Mus81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000307">
        <property type="entry name" value="Crossover junction endonuclease MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10130:FF:000003">
        <property type="entry name" value="Crossover junction endonuclease MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.110:FF:000001">
        <property type="entry name" value="Putative Crossover junction endonuclease MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.670">
        <property type="entry name" value="Crossover junction endonuclease EME1, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042530">
        <property type="entry name" value="EME1/EME2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="HHH_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033309">
        <property type="entry name" value="Mus81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047417">
        <property type="entry name" value="WHD_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047416">
        <property type="entry name" value="XPF_nuclease_Mus81"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13451">
        <property type="entry name" value="CLASS II CROSSOVER JUNCTION ENDONUCLEASE MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13451:SF0">
        <property type="entry name" value="CROSSOVER JUNCTION ENDONUCLEASE MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21136">
        <property type="entry name" value="WHD_MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 14" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0469">Meiosis</keyword>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 14" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="16">
        <location>
            <begin position="302"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="212"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="219"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU369042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK3310622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="594" mass="65926" checksum="D46E7CD6C4E0707C" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M6M8</accession>
    <name>A0AAJ0M6M8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histidine kinase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_408175</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726644.1">
        <property type="nucleotide sequence ID" value="XM_062865336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87884165"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050956">
        <property type="entry name" value="2C_system_His_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058846">
        <property type="entry name" value="PAS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719:SF30">
        <property type="entry name" value="TWO-COMPONENT SYSTEM RESPONSE REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26131">
        <property type="entry name" value="PAS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13188">
        <property type="entry name" value="PAS_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="919"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="1313"/>
            <end position="1470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="150"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1358"/>
            <end position="1386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1366"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="1398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3310864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1486" mass="163793" checksum="F6C771E0E00144F0" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M6N4</accession>
    <name>A0AAJ0M6N4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Asparagine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_571499</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asparagine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726838.1">
        <property type="nucleotide sequence ID" value="XM_062870861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M6N4"/>
    <dbReference type="GeneID" id="87889690"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051786">
        <property type="entry name" value="ASN_synthetase/amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43284:SF1">
        <property type="entry name" value="ASPARAGINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43284">
        <property type="entry name" value="ASPARAGINE SYNTHETASE (GLUTAMINE-HYDROLYZING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13522">
        <property type="entry name" value="GATase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="8">
        <location>
            <begin position="2"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for beta-aspartyl-AMP intermediate formation" evidence="7">
        <location>
            <position position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3311058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="723" mass="81091" checksum="D799434170C06FC1" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M6U5</accession>
    <name>A0AAJ0M6U5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="6">PPIase</shortName>
            <ecNumber evidence="6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_564721</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cyclophilin-type PPIase family. PPIL1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="6"/>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726747.1">
        <property type="nucleotide sequence ID" value="XM_062870650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M6U5"/>
    <dbReference type="GeneID" id="87889479"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000008">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF4">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE DOMAIN AND WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="7">
        <location>
            <begin position="8"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3310967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="168" mass="18295" checksum="77A076E6038794E7" modified="2024-07-24" version="1">MATDVALETSMGTIVLELYNHHAPRTCQNFSTLASRGYYDNTIFHRIIKDFMIQGGDPTGTGRGGTSIYGEKFEDEIHPDLKHTGAGILSMANAGPNTNGSQFFITLAPTPWLDGKHTIFGRVKKGIRVVQRMGLVPTDGEDRPRTEVRINKAYVVTGEEAQEGGLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M754</accession>
    <name>A0AAJ0M754_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pyruvate/Phosphoenolpyruvate kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_482364</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727092.1">
        <property type="nucleotide sequence ID" value="XM_062866097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M754"/>
    <dbReference type="GeneID" id="87884926"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000023">
        <property type="entry name" value="CitE, Citrate lyase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011206">
        <property type="entry name" value="Citrate_lyase_beta/mcl1/mcl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32308:SF0">
        <property type="entry name" value="HPCH_HPAI ALDOLASE_CITRATE LYASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32308">
        <property type="entry name" value="LYASE BETA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13030)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015582">
        <property type="entry name" value="Cit_lyase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HpcH/HpaI aldolase/citrate lyase" evidence="6">
        <location>
            <begin position="11"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3311312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="315" mass="34075" checksum="EDEBA48A8954192E" modified="2024-07-24" version="1">MTSRSIPALRRALLYIPASSSKMVAKSLTLASDNLTYDLEDSVTPSMKVSAREALRDHLTALPNKQHHAGEIAVRINAVSTPHAVDDLKAVASLPSVDTIVVPKVNSASDLLLVEDVIRQIRGQDTRPLNLLALIESAKAVMDLRSICAASSHLKGLIFAAEDFALDLSLERTPGLSEFLYARSAIVTAARAFELESTIDLVCTSFRGSEGQQRLENECLNGRGLGFSGKQCIHPSQIPIVQRIFSPSRKEVEWAARVVVADEKASAVGRGAWTLDGKMIDAPVVGKAHATLGRAERCGCDVDAIKKEWKDENPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GKJ5</accession>
    <name>A0AAJ0GKJ5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA polymerase</fullName>
            <ecNumber evidence="14">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">B0T15DRAFT_441585</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="14"/>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717392.1">
        <property type="nucleotide sequence ID" value="XM_062865922.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87884751"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05776">
        <property type="entry name" value="DNA_polB_alpha_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05532">
        <property type="entry name" value="POLBc_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000004">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3200.20:FF:000002">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000036">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2820:FF:000001">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3200.20">
        <property type="entry name" value="DNA Polymerase alpha, zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024647">
        <property type="entry name" value="DNA_pol_a_cat_su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038256">
        <property type="entry name" value="Pol_alpha_znc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045846">
        <property type="entry name" value="POLBc_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015088">
        <property type="entry name" value="Znf_DNA-dir_DNA_pol_B_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00592">
        <property type="entry name" value="pol2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861:SF1">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12254">
        <property type="entry name" value="DNA_pol_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08996">
        <property type="entry name" value="zf-DNA_Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0235">DNA replication</keyword>
    <keyword evidence="11 14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 14" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase alpha catalytic subunit N-terminal" evidence="19">
        <location>
            <begin position="11"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="17">
        <location>
            <begin position="479"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="16">
        <location>
            <begin position="792"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger DNA-directed DNA polymerase family B alpha" evidence="18">
        <location>
            <begin position="1272"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="57"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="827"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="161"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="210"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="230"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="246"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF08996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF12254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAK3301612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1479" mass="165889" checksum="5FDA1A76E7BEA442" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GKT5</accession>
    <name>A0AAJ0GKT5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_544554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717546.1">
        <property type="nucleotide sequence ID" value="XM_062870093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GKT5"/>
    <dbReference type="GeneID" id="87888922"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3301766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="118" mass="12239" checksum="7DD3D07E775B9D45" modified="2024-07-24" version="1" fragment="single">MAGKWTFQVLSATTATGTGTGSGDNNSSSSNKGGSTSTTDFRLRVMLSEAVVLGTGGVVNLRFEGEAAFRLGREDGNMEGACGGSGVCNWALKEEDTPVVVRQRLVAVECVAGRCEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GL05</accession>
    <name>A0AAJ0GL05_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADP-dependent glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="3">1.2.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Glyceraldehyde-3-phosphate dehydrogenase [NADP(+)]</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Triosephosphate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_578118</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-glyceraldehyde 3-phosphate + NADP(+) + H2O = (2R)-3-phosphoglycerate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.9" evidence="3"/>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717664.1">
        <property type="nucleotide sequence ID" value="XM_062871086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GL05"/>
    <dbReference type="GeneID" id="87889915"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008886">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NADP+) (non-phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008911">
        <property type="term" value="F:lactaldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051020">
        <property type="entry name" value="ALDH-related_metabolic_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42991">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42991:SF1">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="9">
        <location>
            <begin position="69"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3301884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="551" mass="60330" checksum="9F7E4D7431C078EE" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GL11</accession>
    <name>A0AAJ0GL11_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_324865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717622.1">
        <property type="nucleotide sequence ID" value="XM_062864097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GL11"/>
    <dbReference type="GeneID" id="87882926"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3301842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="104" mass="11837" checksum="56E29EB66C31FF98" modified="2024-07-24" version="1">MTFPLHVRCRTHGFPRRCGSGPASGHNGWLFLFEDHIVPKFFANKDLVSDLKQASAFWVQDIDTVVKAKVEDEERYQAELRSLFSSQGHSTDSSKIPFENKTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GL72</accession>
    <name>A0AAJ0GL72_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_286927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3301932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717712.1">
        <property type="nucleotide sequence ID" value="XM_062863653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GL72"/>
    <dbReference type="GeneID" id="87882482"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3301932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="117" mass="13217" checksum="DA1F28C81ACE08C5" modified="2024-07-24" version="1">MVSIAPTSLSASSVVPSTSKIPTSVDEAPRTIRFTNVEHLRETIESTTSDILIVTDITPAQFADFDREDGPLRGVRFRQYNSNSQILIITIPTRLHEALHLELYQSFMRDGQNWSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GLD6</accession>
    <name>A0AAJ0GLD6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteophosphoglycan 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_403032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717858.1">
        <property type="nucleotide sequence ID" value="XM_062865186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GLD6"/>
    <dbReference type="GeneID" id="87884015"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016071">
        <property type="term" value="P:mRNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028322">
        <property type="entry name" value="PNRC-like_rgn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15365">
        <property type="entry name" value="PNRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3302078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="432" mass="46314" checksum="7ABDBA2E06517F72" modified="2024-07-24" version="1">MELRKSQPQKGTPARRRAKRPVNSPARKTYASENDMPSEASLPIELPGPFTPRKSASNSPAPSSQTAHPKPKPRNGNNTRVKQASSPRPPKHGQTTPPQTAAVPKAIPVSAFAGATFHASPAPSSLPIPSFLSKGPGSPSARKDIDRICGEPSPPATDSEAPTPQHRLLKAEPTLQESPLDIFFRADRAEKERARRASSANILRPHPVPFSPPAQIRSPQEPKTVPRELFSSGNRRHGLQRKSSTGIPVSELDGTPGTAVGPAFSKPYQDRIRAARSTEKRGEPMKKPESYDQNPATVDASERLKRLLAIRSVSNGQQPLQVAAVSRGLADLSPPFGTGSQPASASSASHVSGPESPEYSRSFVCPPPPEARYNYTETPPSSGISQAGNRSVITEPVVSRAPEIVHMEDNLRRLLKLNIGSNPALPTSYQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GM59</accession>
    <name>A0AAJ0GM59_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_297469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718010.1">
        <property type="nucleotide sequence ID" value="XM_062863774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GM59"/>
    <dbReference type="GeneID" id="87882603"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3302230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="351" mass="38423" checksum="2042F0F2D48C8DAD" modified="2024-07-24" version="1">MERTRQVVNHNSGALGGMHGEWGRRGTPSSVGTPGPPSRHRLEIRLHSTLFHLPSWFHGPSVRHFIFGMSSGRDNQQGRAVAGRFRDSSQGRGKSKYALERLTWGLPLPSSPSYLSWALAQSPRLLHPLLPNMPLLTRKIARTFPTYLLRAGENPWNPTGWASVDGVSRCNPQPSLSHWGQAEAVCEMETCGKKCLAAIHSFLGFPAWLEPAYHSLQSRDDPMNVTLSISSPNEQDASLRLRKAAATAELPAIHSSTDSCKHHPAACWKGVVGWHTEGPLLIGNLTWKPSEGSASSVYAVLTAASSCYTKGYGSVRDPCSDLTCLSQAQQRLRGLPSFRTAASDLMSFYTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GML2</accession>
    <name>A0AAJ0GML2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0T15DRAFT_514542</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718295.1">
        <property type="nucleotide sequence ID" value="XM_062868130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GML2"/>
    <dbReference type="GeneID" id="87886959"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06867">
        <property type="entry name" value="PX_SNX41_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044106">
        <property type="entry name" value="PX_Snx41/Atg20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051079">
        <property type="entry name" value="Sorting_Nexin_Autophagy"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46979">
        <property type="entry name" value="SORTING NEXIN-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46979:SF2">
        <property type="entry name" value="SORTING NEXIN-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="11">
        <location>
            <begin position="82"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="423"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="393"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="432"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3302515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="603" mass="67246" checksum="2FA6200CB185A1A3" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GMU9</accession>
    <name>A0AAJ0GMU9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_486466</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3302903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718683.1">
        <property type="nucleotide sequence ID" value="XM_062866361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GMU9"/>
    <dbReference type="GeneID" id="87885190"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF43">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="276"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="367"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="422"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="465"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="528"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="50"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3302903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="556" mass="59647" checksum="BBE5A799FA37D8F4" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GN35</accession>
    <name>A0AAJ0GN35_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_505747</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718540.1">
        <property type="nucleotide sequence ID" value="XM_062867538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GN35"/>
    <dbReference type="GeneID" id="87886367"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF80">
        <property type="entry name" value="GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042545441" description="Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="31"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="4">
        <location>
            <begin position="377"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="148"/>
            <end position="151"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3302760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="655" mass="70183" checksum="BA98F3E5D1A3D948" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GNF8</accession>
    <name>A0AAJ0GNF8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Class E vacuolar protein-sorting machinery protein HSE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Class E vacuolar protein-sorting machinery protein hse1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0T15DRAFT_504480</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the STAM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719013.1">
        <property type="nucleotide sequence ID" value="XM_062867500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GNF8"/>
    <dbReference type="GeneID" id="87886329"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033565">
        <property type="term" value="C:ESCRT-0 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21386">
        <property type="entry name" value="GAT_Hse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11805">
        <property type="entry name" value="SH3_GRB2_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16978">
        <property type="entry name" value="VHS_HSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050670">
        <property type="entry name" value="STAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929:SF3">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="15">
        <location>
            <begin position="17"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="14">
        <location>
            <begin position="225"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="176"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="377"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="200"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="401"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="431"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="479"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="524"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="549"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="583"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="651"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="692"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3303233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="727" mass="78046" checksum="793CA04EED4B3E11" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GNJ9</accession>
    <name>A0AAJ0GNJ9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_268795</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719034.1">
        <property type="nucleotide sequence ID" value="XM_062863437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GNJ9"/>
    <dbReference type="GeneID" id="87882266"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF167">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="42"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="342"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3303254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="413" mass="46376" checksum="55EF21E3C5AF7578" modified="2024-07-24" version="1">MAAVVPPDPSTFTPEYVNASNAARIVGVVGVFHFIALTFVSLRLYVRAFMVRAVGVDDLLIVGAAALALMSWICLVLQIPHGLGRHGWVVPVEERIKFEQITFWKTVFSDGVAMGLLRISMAISLLRLKKDLKWYRYSLFAIMGFVVAYSIQAIAWLFVYCTPFSGWWEFQWMNPFDPRCKSFTTFVNLVYWNISCNIFTDVLLGALPVPIIWNLKMRLRVKLYVIGILNLGYLAVLMGILKAVFMLTTGGDPDAIFDYWVHFWENLQLNIGIIAACASFLKPLVGRLLKINSSAGYSYPETPYGRSGNTPHGLQTIGSKYANRRRTADQSHIGDEFELHTKARSSAEGPQVVTSVEGARQPRRASPNYSTEGVDRVPSDTNSEEIILQKQDAPNDGIMMTRDISVRYSTKQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GNK2</accession>
    <name>A0AAJ0GNK2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_495799</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719014.1">
        <property type="nucleotide sequence ID" value="XM_062867124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GNK2"/>
    <dbReference type="GeneID" id="87885953"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3303234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="107" mass="12568" checksum="E5D16E99EE452464" modified="2024-07-24" version="1">MKLNSRRGTAFLDPAGRSWDWKFIPKDAPFGGQDKFSHGWCELDERVVHRADLVLVMGEDERDLLKWCTAVTFALQTKPWLREVDLWKSFVNVDLEFPEGLEPFWLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GNT2</accession>
    <name>A0AAJ0GNT2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_495899</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719116.1">
        <property type="nucleotide sequence ID" value="XM_062867131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GNT2"/>
    <dbReference type="GeneID" id="87885960"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010487">
        <property type="term" value="F:thermospermine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006596">
        <property type="term" value="P:polyamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000288">
        <property type="entry name" value="Spermine/spermidine synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037959">
        <property type="entry name" value="MFS_SpdSyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43317">
        <property type="entry name" value="THERMOSPERMINE SYNTHASE ACAULIS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43317:SF1">
        <property type="entry name" value="THERMOSPERMINE SYNTHASE ACAULIS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01564">
        <property type="entry name" value="Spermine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="1" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3303336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="607" mass="66384" checksum="0E4499F3FEAAB688" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GNY2</accession>
    <name>A0AAJ0GNY2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_275791</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719243.1">
        <property type="nucleotide sequence ID" value="XM_062863514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GNY2"/>
    <dbReference type="GeneID" id="87882343"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF3">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="302"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3303463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="564" mass="63743" checksum="A69636BD7C326813" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GP55</accession>
    <name>A0AAJ0GP55_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="10">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Lysyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0T15DRAFT_496109</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>tRNA(Lys) + L-lysine + ATP = L-lysyl-tRNA(Lys) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="10"/>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719349.1">
        <property type="nucleotide sequence ID" value="XM_062867160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GP55"/>
    <dbReference type="GeneID" id="87885989"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00775">
        <property type="entry name" value="LysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000050">
        <property type="entry name" value="Lysine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000238">
        <property type="entry name" value="Lysine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00252">
        <property type="entry name" value="Lys_tRNA_synth_class2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034762">
        <property type="entry name" value="Lys-tRNA-ligase_II_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00499">
        <property type="entry name" value="lysS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001756">
        <property type="entry name" value="PRK00484.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918:SF9">
        <property type="entry name" value="LYSINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918">
        <property type="entry name" value="LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039101">
        <property type="entry name" value="LysRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="12">
        <location>
            <begin position="264"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="18"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3303569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="617" mass="70467" checksum="C792971372185BBD" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQB9</accession>
    <name>A0AAJ0GQB9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_512355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719947.1">
        <property type="nucleotide sequence ID" value="XM_062867977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQB9"/>
    <dbReference type="GeneID" id="87886806"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3304167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="138" mass="14153" checksum="3281FC13E9C7B384" modified="2024-07-24" version="1">MAIELPTPNLDGRISHTTSGSCVDYRIIGVINLNTTQTLYTQLAFAGNATYQLVPGDPFPSETPVPRPAPGSGPSYSDSNSGGGGGGGSSGGLRPRAIAGIAIGAGAVLIAGAGLIYLYNRRHRFEKAYRKSAQSCAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQD8</accession>
    <name>A0AAJ0GQD8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Eukaryotic cytochrome b561-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0T15DRAFT_233358</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720009.1">
        <property type="nucleotide sequence ID" value="XM_062862978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQD8"/>
    <dbReference type="GeneID" id="87881807"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140575">
        <property type="term" value="F:transmembrane monodehydroascorbate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08761">
        <property type="entry name" value="Cyt_b561_CYB561D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045150">
        <property type="entry name" value="CYB561D1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15422:SF45">
        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15422">
        <property type="entry name" value="OS05G0565100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03188">
        <property type="entry name" value="Cytochrom_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="13">
        <location>
            <begin position="40"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3304229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="246" mass="27048" checksum="30403689345A7367" modified="2024-07-24" version="1">MASTEPTHPAQGDAPAPAESEPLLGRPGDATQRPDAPMIKNIFLGTAWISQLGGVLLLAVTWSSVFTHPKLPLVSPHPLLQTLGVFTGLQAILVLQPTNTPRTKSLGQRYHFILHILSFALFVAGTTIIEVNKHANHMPHFHSPHAYLGVSTFALLVLQYLFGFTIWAVPRVWGGEERAKSMWKYHRWVGYSALVLLLATVAAAVETDYSKAVLRIRLWAVLLAEGLIVVGVLPRVHLRKLGIQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQV4</accession>
    <name>A0AAJ0GQV4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DDHD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_418588</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
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                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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        <source>
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        </source>
    </reference>
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        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAK3304478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062865507.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
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    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Brannstrom I.O."/>
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
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                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
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                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
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                <person name="Lalanne C."/>
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                <person name="Ament-Velasquez S.L."/>
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                <person name="Grigoriev I.V."/>
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                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
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            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
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    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="nucleotide sequence ID" value="XM_062863175.1"/>
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    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Guillou S."/>
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                <person name="Kuo A."/>
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                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
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                <person name="Ament-Velasquez S.L."/>
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                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
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    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
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                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
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                <person name="Ng V."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
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    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF52">
        <property type="entry name" value="SINGLE-STRANDED DNA-DEPENDENT ATPASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="348"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="789"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="234"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3304987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="962" mass="106582" checksum="CBBB26794C8B5184" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GS28</accession>
    <name>A0AAJ0GS28_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">6-hydroxy-D-nicotine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_554907</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720864.1">
        <property type="nucleotide sequence ID" value="XM_062870367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GS28"/>
    <dbReference type="GeneID" id="87889196"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF54">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="11"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3305084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="462" mass="49976" checksum="990258BA530E8118" modified="2024-07-24" version="1">MVHLDRWSKTSILSPSCIFLPSYVEDVSAAVKALSAGNCQFAIKSGGHNPTPGANDINDGVSIDLRYLNQTTLAPDRSFVSLGAGGNWVNAYHAFANHGVGFPGGLCGTTGVGGVTIGGGQSPFSAKVGWAVDNVLNFQLVLADGKIVNANATHNSDLFRAQKGGGSNFGVVTRIDMAAFDHSNQLWGGEIVVQATPATTQTALEATSNYTRQNNANVDAMLQTAFFYYSNGTAVIDFVLAATDNATNPEIFHPFTGMSPQMASTVSSRTLTSFVREIIPTQPRGYRNLWATVTFKNNLATLQTVQRITDHIYIEAGATVPDMDWILLYSPQPKAIDLHGLRNGGNVLGRQHTRDDQIVACISPRWLDAAYDRDMYALAAKWVGMVTKATRLLGTHEEFLYLNLAAQFQDPIRAYGEDNVRFIRHVAEKYDPAGVFQRLAPGGFKISRVGGFRPQTVPGRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GSR7</accession>
    <name>A0AAJ0GSR7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">chitinase</fullName>
            <ecNumber evidence="1">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_532287</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="1"/>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721234.1">
        <property type="nucleotide sequence ID" value="XM_062869305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GSR7"/>
    <dbReference type="GeneID" id="87888134"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000159">
        <property type="entry name" value="Class V chitinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF378">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042555835" description="chitinase" evidence="2">
        <location>
            <begin position="21"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="3">
        <location>
            <begin position="29"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3305454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="392" mass="43720" checksum="E61ABD5F531AD85C" modified="2024-07-24" version="1">MASIRNIWALLVCFVSLSLAVNLTSKPELRCIMYFTGQHPEAPPKSQLQHVTHVAVAFMSPGIFNEPGRADWPMFTTVDDVRTKFPRETKVLVAIGGWGDTIGFAVAALNDETRKMFAENVANMVGATGADGIDVDWEYPGGNGEDYKKVPNSAKEWEIRAYPLLLAELRAALGPDKIISAAVPGLRRDMLAFTRETVPRIMRHVDFLNVMSYDLMNRRDTITKHHTGVELSLEAIDAYVAAGVAPQKLNLGFAFYAKYFMTERDACALSSPVGCPTLLLEDPETGEDLGRSGAFSWHDSVPEDVTESFSRALEHGVYDDQQGGYYYWDAIQHLWWTFDTPDAIKRKFPLIVDKRRLGGVFAWGLGEDAPLFKHYAALVEGLQEHWGAKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GTF3</accession>
    <name>A0AAJ0GTF3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ribonuclease H-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_210579</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the exosome component 10/RRP6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721596.1">
        <property type="nucleotide sequence ID" value="XM_062862671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GTF3"/>
    <dbReference type="GeneID" id="87881500"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071044">
        <property type="term" value="P:histone mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071040">
        <property type="term" value="P:nuclear polyadenylation-dependent antisense transcript catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071039">
        <property type="term" value="P:nuclear polyadenylation-dependent CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071036">
        <property type="term" value="P:nuclear polyadenylation-dependent snoRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071037">
        <property type="term" value="P:nuclear polyadenylation-dependent snRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06147">
        <property type="entry name" value="Rrp6p_like_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000059">
        <property type="entry name" value="Exosome complex exonuclease Rrp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.80:FF:000001">
        <property type="entry name" value="Putative exosome component 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="entry name" value="HRDC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012588">
        <property type="entry name" value="Exosome-assoc_fac_Rrp6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045092">
        <property type="entry name" value="Rrp6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049559">
        <property type="entry name" value="Rrp6p-like_exo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12124:SF47">
        <property type="entry name" value="EXOSOME COMPONENT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12124">
        <property type="entry name" value="POLYMYOSITIS/SCLERODERMA AUTOANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08066">
        <property type="entry name" value="PMC2NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00341">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5" id="KW-0271">Exosome</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="HRDC" evidence="10">
        <location>
            <begin position="452"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="611"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="664"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="630"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="698"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="709"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="738"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="768"/>
            <end position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3305816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="840" mass="94419" checksum="BAB1101666BFB5FA" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GTP7</accession>
    <name>A0AAJ0GTP7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">VID27 cytoplasmic protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_511866</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3306007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062867941.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87886770"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
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        <property type="entry name" value="Vid27"/>
    </dbReference>
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        <property type="entry name" value="VID27_C"/>
    </dbReference>
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        <property type="entry name" value="Vid27_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040768">
        <property type="entry name" value="Vid27_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31913">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31913:SF0">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08553">
        <property type="entry name" value="VID27"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="VID27_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="VID27_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Vid27 PH-like" evidence="3">
        <location>
            <begin position="250"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar import/degradation Vid27 C-terminal" evidence="2">
        <location>
            <begin position="433"/>
            <end position="784"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="427"/>
        </location>
    </feature>
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        <location>
            <begin position="199"/>
            <end position="212"/>
        </location>
    </feature>
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        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF08553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3306007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="816" mass="92087" checksum="2502159C5CD63354" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GTR1</accession>
    <name>A0AAJ0GTR1_9PEZI</name>
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        </recommendedName>
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        <name evidence="4" type="ORF">B0T15DRAFT_574978</name>
    </gene>
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        <lineage>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
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    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721465.1">
        <property type="nucleotide sequence ID" value="XM_062870974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GTR1"/>
    <dbReference type="GeneID" id="87889803"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF9">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="34"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3305685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="147" mass="16041" checksum="D0C123B0503683D0" modified="2024-07-24" version="1">MATNSTLKKVALFGLNGQVCTGYKSRQGRRQLSQDEILDVFKGHDAVVLSLNYMAEMQHHNMLVDASLEAGVKRLIPSIWGGRLDLPEALEIFPIAASKGALLDYVKSKALPAPGWSYTAVACGLFHDLCVLTNFYGFDAEVHTATI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GTZ9</accession>
    <name>A0AAJ0GTZ9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_216984</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3306044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721824.1">
        <property type="nucleotide sequence ID" value="XM_062862750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GTZ9"/>
    <dbReference type="GeneID" id="87881579"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042571489" description="WSC domain-containing protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="4">
        <location>
            <begin position="61"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3306044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="300" mass="31284" checksum="EA3747936C56C770" modified="2024-07-24" version="1">MKSVTFLAAALAALADAMPDPFVPAIELHDGKVGRVGRVGRVARAVPKGEQQPITPPVLDSPTVQGCFKSSGDLVFNTTIKYNTIGICATDTCYHGGFAVGGSTGGNQCWCGNSYPPKDDLVEDSKCNVPCPGFGDHACGGIDTWTIYNTGVTLAVKYKDDPSTTKSSTSSTSSPTQSATKVGETVVVTATPTSDAEKKPSGGTNTGGIVAGVVVAVVVVAAAVAGGFFYLRRKRNQEIEEEHRRNAAVSAFIGKPPGSSSGTSMTDSRLDPVMAQRRMSDGSIADNQDYSRRILRVTNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GU61</accession>
    <name>A0AAJ0GU61_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_502939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721690.1">
        <property type="nucleotide sequence ID" value="XM_062867449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GU61"/>
    <dbReference type="GeneID" id="87886278"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="201"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3305910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="286" mass="30249" checksum="C8B0D4AA206F8BAF" modified="2024-07-24" version="1">MPDEATQGLAQSIAKQVERVVHRGMVEFTLRSLMNAGMTANEVSDLVKAVLHDLNGDPAPDVARADAEATTKATAEAQAILQALQLITECTANMPPIKKAAVSTGESSAMAAGPRTKFAAGVKRKLAQSQSQATTLTGTTSTAATSPMYTPTTSKTSEQSSASSTANLSPAARVPFVVAAVAAAAAVRAQQQKKKHDSRGSDNGSSGASSSSLGKTTDSEASIFGFQRRVRKTMAQRARRPGCNRAELYDDWTCPTWRSDSEEDSDDEGDEDEDEESEDEDEDDIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GU64</accession>
    <name>A0AAJ0GU64_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_556943</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3306149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721929.1">
        <property type="nucleotide sequence ID" value="XM_062870432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GU64"/>
    <dbReference type="GeneID" id="87889261"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853:SF1">
        <property type="entry name" value="LIPASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029171">
        <property type="entry name" value="Esterase_LipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042460575" evidence="1">
        <location>
            <begin position="21"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="141"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3306149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="468" mass="50931" checksum="975828BD3182DC54" modified="2024-07-24" version="1">MYWPAFSAFSLACLAGTAWAQQPICDVECQKGCNDECQTAIQSAFDGESKQWVGDIISDPFYTTPSNITGAVPGDILRWEDVPTKQLTNNWTIPAGLSLSRFMYVTEDIDNSSIPATAWVLLPFHHNLPTPGEPGKLRTVVWTHGTAGRSRLCSTTNNKGLYYNWQAPFTLAESGYAVIAPDYAGQGSDIPQGFMYEAGFLHAADVAYSVIAARRAIGGILSDKWAVFGHSEGGMTAWRTNERLALPGNERLHKAGTFVGAVAAAPALRPQRLIPLSWEETGTGGGPFSVYFLQSLARLYPDQIKVEDYLGETVLQRLGLLDSSCFVTGFTAVGTLSPDATFANKSWLDHPATNDWAVRYNGQGPHRLSAPMLVVQGVSDTITPASLTVEDFNLTCSTYPESVAHAKLYPGMGHGQVLEAGRADIADWLDARFNGKCLRKGCVVEEIRPLTERYAQGELFWAAETVAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GU80</accession>
    <name>A0AAJ0GU80_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CinA C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_494271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3306159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721939.1">
        <property type="nucleotide sequence ID" value="XM_062867001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GU80"/>
    <dbReference type="GeneID" id="87885830"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.20">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CinA C-terminal" evidence="1">
        <location>
            <begin position="24"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3306159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="103" mass="10889" checksum="DC22AEEA8D4C1228" modified="2024-07-24" version="1">MASTANADYIPRTTESLFGGAEPTTWGIGTTGIAGPDMRDGKPAGTVFIGIASPGKSHVFGPFNFPGSRKQVRELTVLEALARLRAELVARAEENKTKVVCNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="4">Rrn9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">B0T15DRAFT_503202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3306234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722014.1">
        <property type="nucleotide sequence ID" value="XM_062867463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GUD1"/>
    <dbReference type="GeneID" id="87886292"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="311"/>
        </location>
    </feature>
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        <location>
            <begin position="371"/>
            <end position="404"/>
        </location>
    </feature>
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        <location>
            <begin position="32"/>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="388"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3306234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="404" mass="44752" checksum="9FA400A46291B018" modified="2024-07-24" version="1">MSYIISLDNTCRAKLRKQAALTKDLVKDATHAIRDNDHAESDSDDSDDSESFGTGSTSSQDIIQMIEGLKTDIQCLVALGPRFREPFLDKSHWSDREEAAAPPQQTGWNPVEFLTSRIRHRYPDADPAFAQILGQANWERAQRLYTAKEKNTQDATTSTSSSQKPVLEADSASVPPETVIESAFHDSGLGNSLSTANYAETMFSYHGTNGISIKIPPIPAAGRQGKPAKVSHFAQHLEEVTLMILPANAEPEGLDVEAVDSEDEPIMSSRWFLNRYREDLSDEEATTTSSSRTNKPSPTPKAEMASQAEPHVETGSAAWYLGPQPPRAFRCLFEPCPYWSTRESNRKKHMEKPHRWISDRGSDIESILLSESMTEEKEKASSYKKVSEATDLPSHPSVAGLRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GUI7</accession>
    <name>A0AAJ0GUI7_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_137493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722104.1">
        <property type="nucleotide sequence ID" value="XM_062861834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GUI7"/>
    <dbReference type="GeneID" id="87880663"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3306324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="103" mass="11089" checksum="75689CD9A0E74F31" modified="2024-07-24" version="1">MNRGKSGIGSELGLIQKSRLLPPGCFLFRHSLLFLAVGMYWTSSLPFARAGPGVQWCGGVLLPSLFFITGVLLCGVLLIALSLGCWFINNTLMVETDDALSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GUP7</accession>
    <name>A0AAJ0GUP7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_393431</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722253.1">
        <property type="nucleotide sequence ID" value="XM_062864685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GUP7"/>
    <dbReference type="GeneID" id="87883514"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF40">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="35"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="482"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="508"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3306473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="521" mass="57233" checksum="5A59759A11ACBE96" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GUQ5</accession>
    <name>A0AAJ0GUQ5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_566173</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722105.1">
        <property type="nucleotide sequence ID" value="XM_062870689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GUQ5"/>
    <dbReference type="GeneID" id="87889518"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3306325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="38441" checksum="F1CF6B0E74AED066" modified="2024-07-24" version="1">METPVPYGCSPGNASPTLVGIRYVGDGLSSALFSFHYNGVPFHIVAANPEDHAGGETLVPPRYDFADSVEGRILQTIYALSQQFDEADADKARKRLEEQFADLAAMLYPVTHTLQVLTDFGQSELAFTCRIMDGYPVIPEPVSEHWLRAIGLDLTATNVPIVDASQVFLVCHLQGLAWKVTMAGEVMVCKTTNESMRGLDIAAELGTLLRIRSANARLSVPELKAIVVSRRGVVGILRFPNAGDLYHLLARIGLGDTLAERTISFRRMWALQIWDTKKALSKLGIWPWYDLRTDNIIINEDGDAVLLGLGGRNELPWVCHYPDGSVHGDAVKLLRIMSALKVERLSDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GUT4</accession>
    <name>A0AAJ0GUT4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glucose-methanol-choline oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_222984</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3306255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722035.1">
        <property type="nucleotide sequence ID" value="XM_062862833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GUT4"/>
    <dbReference type="GeneID" id="87881662"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF138">
        <property type="entry name" value="DEHYDROGENASE PKFF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042541034" evidence="6">
        <location>
            <begin position="22"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="8">
        <location>
            <begin position="301"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="538"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="581"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="537"/>
            <end position="538"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3306255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="603" mass="65451" checksum="5AF15DA0B55ADAAF" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GV12</accession>
    <name>A0AAJ0GV12_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_149872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722468.1">
        <property type="nucleotide sequence ID" value="XM_062861980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GV12"/>
    <dbReference type="GeneID" id="87880809"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042478493" evidence="1">
        <location>
            <begin position="21"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3306688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="133" mass="12927" checksum="EA1C1F1044C5762F" modified="2024-07-24" version="1">MHLLLPPLALTLALVRLTTALPLNINLGAYSPALVVGDGAISFEGEEGAAAGGGQSAEQIVNALQGAAVSGASAAAAAAAANNNNNNNGAASVTPPAVGAAAVVQIDEPSPTVVLLNDPATSVSGKELDPRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GV54</accession>
    <name>A0AAJ0GV54_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Lon protease homolog, mitochondrial</fullName>
            <ecNumber evidence="11">3.4.21.53</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PIM1</name>
        <name evidence="17" type="ORF">B0T15DRAFT_148833</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homohexamer or homoheptamer. Organized in a ring with a central cavity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11 12 13">Belongs to the peptidase S16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="11"/>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GV54"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141164">
        <property type="term" value="P:mitochondrial protein quality control"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070407">
        <property type="term" value="P:oxidation-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd19500">
        <property type="entry name" value="RecA-like_Lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000021">
        <property type="entry name" value="Lon protease homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000113">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.5270:FF:000001">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1480:FF:000003">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.130.40:FF:000006">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000015">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.5270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="entry name" value="LON domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03120">
        <property type="entry name" value="lonm_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004815">
        <property type="entry name" value="Lon_bac/euk-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054594">
        <property type="entry name" value="Lon_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027503">
        <property type="entry name" value="Lonm_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008268">
        <property type="entry name" value="Peptidase_S16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00763">
        <property type="entry name" value="lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43718">
        <property type="entry name" value="LON PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43718:SF2">
        <property type="entry name" value="LON PROTEASE HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22667">
        <property type="entry name" value="Lon_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00830">
        <property type="entry name" value="ENDOLAPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01046">
        <property type="entry name" value="LON_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 11 12" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="16">
        <location>
            <begin position="168"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="15">
        <location>
            <begin position="880"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="74"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="274"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="813"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1074"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="274"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="813"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1074"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="active site" evidence="11 12">
        <location>
            <position position="972"/>
        </location>
    </feature>
    <feature type="active site" evidence="11 12">
        <location>
            <position position="1015"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="592"/>
            <end position="599"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK3306657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1098" mass="120543" checksum="CD5776D3B0C6DA3E" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GVB0</accession>
    <name>A0AAJ0GVB0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_148839</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722435.1">
        <property type="nucleotide sequence ID" value="XM_062861963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GVB0"/>
    <dbReference type="GeneID" id="87880792"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018828">
        <property type="entry name" value="RRG7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28133">
        <property type="entry name" value="REQUIRED FOR RESPIRATORY GROWTH PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28133:SF1">
        <property type="entry name" value="REQUIRED FOR RESPIRATORY GROWTH PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10356">
        <property type="entry name" value="RRG7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="29"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="45"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3306655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="291" mass="31510" checksum="83E095FC79416AE6" modified="2024-07-24" version="1">MRGSLPRRLRSPRLPVPVLRCAFSSAALAHPIPESTPEAEPSKPPTQQQQQSPPVNQNAASPDSETTTTTAHTTSPPINPPLIYPSAPSPHHTDLPTFLAYAERTNLDPSSTVYVGTHFEYTVSDTLARFGLHLRRVGGVSDCGIDLLGTWSVPSYPRRARPLRVLAQCKAVQRPGPHLVRELEGAFVGAPAGWRGPVGVVGLLVTEKPATKGIRDALGRSTWPMGFVACSREGRVQQFLWNQRAREEGLEELGVTARHVNGDGEGEPETELVLTWRGKTLPFGSRGETGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GWC9</accession>
    <name>A0AAJ0GWC9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Septin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_163463</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722845.1">
        <property type="nucleotide sequence ID" value="XM_062862133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GWC9"/>
    <dbReference type="GeneID" id="87880962"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032156">
        <property type="term" value="C:septin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000196">
        <property type="entry name" value="Cell division control 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="5">
        <location>
            <begin position="64"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="416"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3307065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="440" mass="50308" checksum="AEF663D446B85BB3" modified="2024-07-24" version="1">MTVPVPRVQSPSSGLDVSQRTPSDSMAAAPPATSDNTHIVRRKLTGYVGFANLPNQWHRKSVRKGFNFNVMVVGESGLGKSTLVNTLFNTSLYPPKERKGPSLDIIPKTVTIQSISADIEEAGVRLRLTVVDTPGFGDFVNNDESWRPIVDNIEQRFDAYLDAENKVNRMNIVDNRIHACVFFIQPTGHSLKPLDIEVMKRLHTKVNLIPVIAKADTLTDEEVAAFKARILADIKYHKVQIFEGPRYELDDEETIAENNEIMSKVPFAVVGSNDEVTNADGRKVRGRSYPWGVIEVDNEEHCDFVKLRQMLIRTHMEELKEHTNNVLYENYRTDKLIAMGVSQDPSVFKEVNPAVKQEEERALHEQKLAKMEAEMKMVFQQKVAEKESKLKQSEEELYARHREMKEQLERQRLELEEKKSRIESGRPLEKEPKRKGFSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GWF4</accession>
    <name>A0AAJ0GWF4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_530144</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723188.1">
        <property type="nucleotide sequence ID" value="XM_062869156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GWF4"/>
    <dbReference type="GeneID" id="87887985"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042531886" evidence="2">
        <location>
            <begin position="21"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3307408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="185" mass="18877" checksum="6F7629448CA0A870" modified="2024-07-24" version="1">MTRILITILAATAAFWQAMALPAAQGGGEGEAGGPSPTRSTHPGGPRPTHTLSLSLPPRPTGSPSFSLPPRPSGSHSPPPPPPPPPPPPPPPRPTRSHSFTFPPQPPTGTHSLPPRPTGSHPAPPSISTHSLPPRPTGSHSFSFPPQPPTGTHSLPPRPTRTVTRSRGPRPTTTTSAGSSAGGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GWW6</accession>
    <name>A0AAJ0GWW6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_182910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723354.1">
        <property type="nucleotide sequence ID" value="XM_062862330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GWW6"/>
    <dbReference type="GeneID" id="87881159"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3307574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="157" mass="17477" checksum="8F0C20DA26514E68" modified="2024-07-24" version="1">MASNASRLTLGRYLPSPLFPRQSVYRRGLRLYALVLFQARRRGRDLRGLLSPNIILTPTYGTSQTTVSVRHAAVCPPRISSLRRLGTRQGRPVVGVLTFMVLLSGEVVSMFFSQGPHSYVSCPLVCSRVASAGARLQFRTYRGISLAACIKFHMIHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GX13</accession>
    <name>A0AAJ0GX13_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_502186</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723501.1">
        <property type="nucleotide sequence ID" value="XM_062867418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GX13"/>
    <dbReference type="GeneID" id="87886247"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3307721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="448" mass="50779" checksum="485839089060259E" modified="2024-07-24" version="1">MQDADLLVAQHALRGFQLRSTCSVSLTYANSDSSNIGTEELAAANTQGAASTSAVVSSVKFRLDDVYPPCYSIEKRAAQRVVDGNNTKRSNPRWSPWCESLTLIRRLTKERHGGQARAVREVEVSPFNKRHCPEEDAALDPKIVRALARLVKALPCLRHFCSWSLAPDVDALIRALNDHPSYPELHLLYEDGSRTVASPMPSWARWRDKMNWSSPTSLSLGRQRTTRLLHYFGGHATALRSLTVEKWARKGGDHCPELEDFLLCFDSLEQLTVRGHFVSNRALCHHPRLKRLCLHAMEINRGGAAHPTMTVDDLRELDTQFPGLEDLEIDIYRDGNGWPQDIIRALAFGFASIEQLALHSETLDLKLAWAFAEPFFAWRRPGSKLKGLILKTGERLRRFPQLIPPYRREEIRQSVTVHVQAPRDGTMALDVIDVNDPRSEFFNFFHAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GXD7</accession>
    <name>A0AAJ0GXD7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_523059</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3307927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723707.1">
        <property type="nucleotide sequence ID" value="XM_062868662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GXD7"/>
    <dbReference type="GeneID" id="87887491"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02603">
        <property type="entry name" value="HAD_sEH-N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052898">
        <property type="entry name" value="ACAD10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829:SF1">
        <property type="entry name" value="HAD FAMILY PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3307927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="307" mass="33926" checksum="81ACF560833A2306" modified="2024-07-24" version="1">MFSKEFSVELILETIDNMSQSPPKVVLFDIGGVCVVSPFQSILDYELSRGIPPGWINYSIAKSAPNGFWHRLETGSIPMDAAFFAGFNADLHDQSRWEAFYRAQQARNPSVSSSSLPKQEVPPLPQVDGEWLFHDMMAAARAPDPWMYPALKALKASGQYMVAALSNTVIFPPDHVYSQKDFLDDPVRSLFDVFVSSAHVGLRKPDPRIYQLALERVDEFAKANADSDRGRALGWSEGVSAGEIVFLDDIGENLKAAKAAGFRTIRVPLGRAYEAVEELEKVTGLKLAGDHPKIPVKPNFRGSKAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GXG9</accession>
    <name>A0AAJ0GXG9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SUMO-conjugating enzyme UBC9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Ubiquitin carrier protein 9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin-conjugating enzyme E2 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Ubiquitin-conjugating enzyme E2-18 kDa</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B0T15DRAFT_91396</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3307958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723738.1">
        <property type="nucleotide sequence ID" value="XM_062871447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GXG9"/>
    <dbReference type="GeneID" id="87890276"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019789">
        <property type="term" value="F:SUMO transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23798">
        <property type="entry name" value="UBCc_UBE2I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000035">
        <property type="entry name" value="SUMO-conjugating enzyme ubc9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 16" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="17">
        <location>
            <begin position="3"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="15">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00081544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK3307958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="157" mass="18229" checksum="F8EC5D0EED278417" modified="2024-07-24" version="1">MSLCQNRLQEERKQWRKDHPFGFYARPQKNAQGVLDLKVWECGIPGKEKTIWEGGLFKMIVTFPDEYPTKPPKCKFVPPLFHPNVYPSGTVCLSILNEEEAWKPAITIKQILLGVQDLLNDPNPESPAQAEAYNMFKKDRMQYERRIKQIVRENAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GXI8</accession>
    <name>A0AAJ0GXI8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_92329</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat rae1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3307974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723754.1">
        <property type="nucleotide sequence ID" value="XM_062871456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GXI8"/>
    <dbReference type="GeneID" id="87890285"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000190">
        <property type="entry name" value="Nuclear pore complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="74"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="115"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="261"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3307974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="357" mass="39457" checksum="1A05EC025796DCBA" modified="2024-07-24" version="1">MAGLFGSASAATSNTLGDLSKDVELGSPPEDSISDLAFNPNPTDPKDFLAVASWDKKVRIYEIMSNGQGQGKAQIEHDGPVFSVDFFKDGQKVISAGADKQAKLLDLATGQLAQVAQHDQPVRCVRYFEVNGTPMAVTGSWDKTVKYWDFRSAQPAGVVNCQERVYTMDVRDNLLVIGTADRYINVINLKEPAKFYKTLQSPLKWQTRVVSCFTDSQGFAIGSIEGRCAIQYVEDKDASMNFSFKCHRDQPQGNVTNVYAVNDISFHPQHGTFSTAGSDGTFHFWDKDAKHRLKGYPNVGGSITSTTFNKTGTIFAYSISYDWSKGYQGNTANYPTKVMLHPVQPDECKPRPSVKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GY38</accession>
    <name>A0AAJ0GY38_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_102314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724012.1">
        <property type="nucleotide sequence ID" value="XM_062861374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GY38"/>
    <dbReference type="GeneID" id="87880203"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3308232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="383" mass="42767" checksum="57540455B1E2DD79" modified="2024-07-24" version="1">MLSIKGAESGVPNRAFRRGRTKPRVPTVGGSAKYSSWLFVLMMVRPYVYGGEYKPPKFNRGHKRRRPHRGITHDGVTTAMDSTARNNLFPLACPSTSCSRGDTIAVPETHCLLVLRPMPRRQSQACLTCCYAAAVGKGVIQRPLQGLGAVRLRGNYTPTVDRRGPGSGPDTRIRLATAIPSPRSLSSERRRFEKQTNKPSLRTYRYQCQDTSQRKATGRVRAVFPFQQTAAPHPHCLLSMPRQCPAPKSGSSPLQIHGYTGAGRQLKVYTAVETETESSSITPSIGRLWGRVADLLRALERCLNSRRPHIFPVSQYVRPCLPGLPDKAPVRRQRGREKRSMQAFCWFLFEEERTRPSHTPVLTLHRPDLADLTRAGACLVCKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GY55</accession>
    <name>A0AAJ0GY55_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0T15DRAFT_95079</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723820.1">
        <property type="nucleotide sequence ID" value="XM_062871483.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87890312"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008574">
        <property type="term" value="F:plus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047496">
        <property type="term" value="P:vesicle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22705">
        <property type="entry name" value="FHA_KIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01365">
        <property type="entry name" value="KISc_KIF1A_KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000021">
        <property type="entry name" value="Kinesin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000047">
        <property type="entry name" value="Kinesin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022164">
        <property type="entry name" value="Kinesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022140">
        <property type="entry name" value="Kinesin-like_KIF1-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032405">
        <property type="entry name" value="Kinesin_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12473">
        <property type="entry name" value="DUF3694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12423">
        <property type="entry name" value="KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16183">
        <property type="entry name" value="Kinesin_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Kinesin motor" evidence="14">
        <location>
            <begin position="13"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="13">
        <location>
            <begin position="1556"/>
            <end position="1750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="621"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1453"/>
            <end position="1494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1518"/>
            <end position="1538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1621"/>
            <end position="1702"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="755"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="621"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1459"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1630"/>
            <end position="1640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1642"/>
            <end position="1652"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="110"/>
            <end position="117"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3308040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1771" mass="195186" checksum="5880309B1C85C6F0" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GYB1</accession>
    <name>A0AAJ0GYB1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_107475</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the PTH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724191.1">
        <property type="nucleotide sequence ID" value="XM_062861444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GYB1"/>
    <dbReference type="GeneID" id="87880273"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1470">
        <property type="entry name" value="Peptidyl-tRNA hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001328">
        <property type="entry name" value="Pept_tRNA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018171">
        <property type="entry name" value="Pept_tRNA_hydro_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036416">
        <property type="entry name" value="Pept_tRNA_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17224">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17224:SF1">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01195">
        <property type="entry name" value="Pept_tRNA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53178">
        <property type="entry name" value="Peptidyl-tRNA hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01196">
        <property type="entry name" value="PEPT_TRNA_HYDROL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3308411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="201" mass="22796" checksum="DDA8DF223E59EC3F" modified="2024-07-24" version="1">MPDLKRIIIVSLGNPGRALDTYHSAGHQVLELLPLQLGRQHPSFDNMRIAKKTTRCSIGQRYSLFQSPTVMNVSGPWVSKAYHEHLAEQKLKPGEVGFVLVHDDMEEELGAVKIREWDRSHRGHNGVKSVKESLRAYPEGSWARVSVGIGRPREDPKARDRNTVSDFVLMTIPPKEREVLETVGPPRLLDCLYELEAKWGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GZ47</accession>
    <name>A0AAJ0GZ47_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha</fullName>
            <ecNumber evidence="4">2.5.1.58</ecNumber>
            <ecNumber evidence="3">2.5.1.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">CAAX farnesyltransferase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">FTase-alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Ras proteins prenyltransferase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Type I protein geranyl-geranyltransferase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0T15DRAFT_525347</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.58" evidence="4"/>
    <dbReference type="EC" id="2.5.1.59" evidence="3"/>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724584.1">
        <property type="nucleotide sequence ID" value="XM_062868839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GZ47"/>
    <dbReference type="GeneID" id="87887668"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005953">
        <property type="term" value="C:CAAX-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005965">
        <property type="term" value="C:protein farnesyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004662">
        <property type="term" value="F:CAAX-protein geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004660">
        <property type="term" value="F:protein farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF1">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE_GERANYLGERANYLTRANSFERASE TYPE-1 SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51147">
        <property type="entry name" value="PFTA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="18"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="109"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3308804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="577" mass="63962" checksum="CB05EECEBAB3A00F" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GZA3</accession>
    <name>A0AAJ0GZA3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_525689</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724696.1">
        <property type="nucleotide sequence ID" value="XM_062868865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GZA3"/>
    <dbReference type="GeneID" id="87887694"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050997">
        <property type="entry name" value="MAPEG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10250:SF26">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10250">
        <property type="entry name" value="MICROSOMAL GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3308916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="148" mass="16053" checksum="B3C2A960CF86BEE6" modified="2024-07-24" version="1">MALFTLPNEYGYVLLAASSTFFVNTFHGILTSSRRRTANIKYPTTYASAEQAEKDPKAYAFNCAQRAHANFTENLTPFLGALLISGLKYPVYAAGLGAVWSVSRVFFALGYVRAGPQGRTTGGYPASISDLILKLMAAYTSLSFALGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GZB3</accession>
    <name>A0AAJ0GZB3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_123241</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724716.1">
        <property type="nucleotide sequence ID" value="XM_062861658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GZB3"/>
    <dbReference type="GeneID" id="87880487"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3308936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="164" mass="18820" checksum="0B4EEAB25FFDC940" modified="2024-07-24" version="1">MATAHPVPNNHTGKYWRPWSFVAFFPRLPTTSSRLGRGYSMPFRTWLVALAAELEIAKNTATLMHHQGSPHAYRGASFTFLWWRRLAGQQQHIFGQREQPLMTMSPAVGNVTWKLDGNVAIVTPLLEVRQIRECANRAEATYDYRLVQWCDEKPHFAQEIGPNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GZE9</accession>
    <name>A0AAJ0GZE9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_390603</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat CDC20/Fizzy family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724702.1">
        <property type="nucleotide sequence ID" value="XM_062864549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GZE9"/>
    <dbReference type="GeneID" id="87883378"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056150">
        <property type="entry name" value="WD40_CDC20-Fz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF1">
        <property type="entry name" value="FIZZY-RELATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24807">
        <property type="entry name" value="WD40_CDC20-Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CDC20/Fizzy WD40" evidence="7">
        <location>
            <begin position="238"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="282"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="365"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="496"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="135"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3308922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="549" mass="61301" checksum="4500553DC6A6262D" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GZF1</accession>
    <name>A0AAJ0GZF1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_115937</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724480.1">
        <property type="nucleotide sequence ID" value="XM_062861554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GZF1"/>
    <dbReference type="GeneID" id="87880383"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF25">
        <property type="entry name" value="ABC-TRANSPORTER-REGULATING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="69"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="153"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="726"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="919"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="179"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="195"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="742"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="785"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="818"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="920"/>
            <end position="931"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3308700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="942" mass="104361" checksum="685B326C75704096" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GZY5</accession>
    <name>A0AAJ0GZY5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_121039</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724640.1">
        <property type="nucleotide sequence ID" value="XM_062861625.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87880454"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF33">
        <property type="entry name" value="MEMBRANE PROTEIN WSC4, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G09020)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042579464" evidence="7">
        <location>
            <begin position="20"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="176"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="277"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="334"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="177"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="223"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="377"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="398"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="433"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3308860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="442" mass="45574" checksum="ADEDEA320698E128" modified="2024-07-24" version="1">MSRALRCAALSCALGLAEAKALKWGADAATWVPARETVTFGVMSRLGMIEPTPTPAPYPQGEPRKVEARGTTDNTCGYMSGILTSSLYCDPTASCVYNESNMHIGCCDDGETRCPIWTTCYDSTDSAKYTTRNGLTLWCGQSEYPHCFTHTYEDQALKGYTVLGCAVAGGTGKVWYSPTSRPSSSDSSSTSSTSSISDPTSTSSSPTTRAAAATDGPNGGSNGDSNSDGDSNGSSSSSTPVGPIVGGVVGGLGAVALIILGIWMLMRQRKKGSQAAAAAAATQQYQSHAPPPPGPGHQDPHMSQYYGAAAGAGFSPMDPRASIAKPPAYAGAMPHSPYGSPGPDQAAVSSMTSSPPHSPSPAYHPHGTPSPPPPQQQPGQFGQPQPQPQQQAYGNVSPGAAYPQQGQPGYGAGGNGYPQQQQQYTAELPATRGDGELRELQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H0A0</accession>
    <name>A0AAJ0H0A0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Tyrosinase copper-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_481108</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725167.1">
        <property type="nucleotide sequence ID" value="XM_062866005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H0A0"/>
    <dbReference type="GeneID" id="87884834"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF126">
        <property type="entry name" value="TYROSINASE-LIKE PROTEIN TYR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="3">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="4">
        <location>
            <begin position="231"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3309387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="305" mass="34523" checksum="00D12147B8C2C1D5" modified="2024-07-24" version="1">MRFPLALQRLHQPRAARRVAEPEHVFRAQYVESVLCLKSKPSELGLNTTRYDNFPYVHNRLNHISEHVPFSRPPHFCSLLNRSRVVHAVAMFLPWHRNFVALYEEALRDCGYTGPMVYWDWSLEADTGLGGNGNRAEGGSDRKCVADGPFKDLRPAYYGDDYAPHCLSRNWNNGTDRPGDMIASTYTPDAVGEVMASQSYQDFRYSLEGGPHRAIHAAVGGDMSPATSPNDPLFFLHHTQVDRLWWLWQQQDPAARTTAFGGPRTQDEDSLEATLEDVMPFLGLAEDVQVSELMTTQSGRLCYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H0M2</accession>
    <name>A0AAJ0H0M2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Restriction of telomere capping protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_506378</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in a process influencing telomere capping.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RTC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725404.1">
        <property type="nucleotide sequence ID" value="XM_062867569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H0M2"/>
    <dbReference type="GeneID" id="87886398"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039024">
        <property type="entry name" value="RTC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028094">
        <property type="entry name" value="RTC4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41391">
        <property type="entry name" value="RESTRICTION OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41391:SF1">
        <property type="entry name" value="RESTRICTION OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14474">
        <property type="entry name" value="RTC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01312">
        <property type="entry name" value="RTC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Restriction of telomere capping protein 4 C-terminal" evidence="9">
        <location>
            <begin position="400"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="95"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="112"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="190"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="262"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3309624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="531" mass="59194" checksum="69ACD96AC368618C" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H0S9</accession>
    <name>A0AAJ0H0S9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_386593</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725135.1">
        <property type="nucleotide sequence ID" value="XM_062864333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H0S9"/>
    <dbReference type="GeneID" id="87883162"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35569">
        <property type="entry name" value="CYANAMIDE HYDRATASE DDI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35569:SF1">
        <property type="entry name" value="CYANAMIDE HYDRATASE DDI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3309355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="260" mass="29252" checksum="10370E5D7B75165E" modified="2024-07-24" version="1" fragment="single">GTIRHRLREMVPKHPACEKAFSIAQADLPAPIFNHSFRVFLYAQTFMISEFPGPDAPGAVTLRHEFKPPPYLEAPSVRDPNRSVALFVACMLHAYRTDPRYDATAMRFELCGADATAKVLGRHGFSVLTIREAWLAVALHTTPRIAEDLNGIIRALRLAVRADFHCFPLPNLRLLPGGFQPGELSRLIDAELPRLDVEKALADRIVDWARNKPDEVFERAKAPRSTWPGELVEVMRADSQLSRWRVMGLESGTALNRAFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H0Z2</accession>
    <name>A0AAJ0H0Z2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_5226</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
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                <person name="Natvig D.O."/>
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                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
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                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
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                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
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                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
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    </reference>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Kuo A."/>
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                <person name="Labutti K."/>
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                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 333.67</strain>
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    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725823.1">
        <property type="nucleotide sequence ID" value="XM_062866031.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87884860"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3310043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="119" mass="12743" checksum="CFC1F53986620248" modified="2024-07-24" version="1">MSIALKLRNFTRPIVQATRITASSFVRMQSTNQHGQGASHATGHSKVPGKVQEAAPQGLEEALPDKLHPTGAEPGQSTHKTHAKDDGNASIVPKKVQEKLPESIERAVPNVIHDTGSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H1Q0</accession>
    <name>A0AAJ0H1Q0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B0T15DRAFT_17866</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725694.1">
        <property type="nucleotide sequence ID" value="XM_062862273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H1Q0"/>
    <dbReference type="GeneID" id="87881102"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03213">
        <property type="entry name" value="ABCG_EPDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000702">
        <property type="entry name" value="ABC transporter (Adp1)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF2">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0732">Signal</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042512843" evidence="15">
        <location>
            <begin position="25"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="824"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="857"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="900"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="937"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="967"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="998"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1027"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1056"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="79"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="17">
        <location>
            <begin position="368"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="654"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="654"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="681"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK3309914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1079" mass="117848" checksum="41A758F4FA7064A0" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H1W2</accession>
    <name>A0AAJ0H1W2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_517756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725992.1">
        <property type="nucleotide sequence ID" value="XM_062868329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H1W2"/>
    <dbReference type="GeneID" id="87887158"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="11"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3310212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="245" mass="28516" checksum="2BDD8E3A2065D1CB" modified="2024-07-24" version="1">MDLRGYSLPIHTPYYPHLRGRSGETKPDLRDPYMYEPDHSVGNLSLSEDQPEDMPYWTGSPKRHAHRGSPRGSDHNPRERKKPLGMPRKENPGIDVALRNLHHEVSTSLKMFQAFVQCFESQVKPLQDWAEDYTLDTVWRNKVKDQFRGKRDRGKFEGAAARFLDNRTTIKNAVRNAKSLNEACDDKYKIEREIRTAKKALLYCDGIIDLAERSPSERLACKQLVTELEEVKCLLERRKHPWICK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H227</accession>
    <name>A0AAJ0H227_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_488786</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725870.1">
        <property type="nucleotide sequence ID" value="XM_062866539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H227"/>
    <dbReference type="GeneID" id="87885368"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF11">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="213"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="279"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="73"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="287"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3310090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="416" mass="44920" checksum="25610F4CC0A4350F" modified="2024-07-24" version="1">MVESSASSDPDPGPNRPSFKSFWKKSKQVLGAKTIRFVDSNPTKESGPDKAQLRRAQVRRAQMQHRQRKASYVRQLEMDVARIRGMIEAAERESQVLLDENQAMRAQLRNAAATDVSLPVSLPVSIPMSPDTVASLRQELDAVTITLGFDEIMDAPAFYISSPPPPAYPCPPFPRPAAPSPAALPDLTPSETQAAINFILALEHICRDHFHPSLYHPPAPEDADDADGSAPPPQHNNPFDFFLGNDSNGHTLMATSLALRNAPAHIFKAAARTRPLPGVNLISRRPSVPPLPPPPPPPPAPSSSPPPPPPAAHPSAAADDSTGLSWKTSGLTLRSLYGLACSLNPPSLADGGEITPVQAWFELVARFGAATLMQEGVLDQLKRGFVRAVKCPHFGASMKRRDFERIVGLVIGKHGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H2J6</accession>
    <name>A0AAJ0H2J6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="1">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_387143</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="1"/>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726110.1">
        <property type="nucleotide sequence ID" value="XM_062864366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H2J6"/>
    <dbReference type="GeneID" id="87883195"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02662">
        <property type="entry name" value="Peptidase_C19F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF904">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
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        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="4">
        <location>
            <begin position="52"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="213"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="449"/>
            <end position="587"/>
        </location>
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        <location>
            <begin position="220"/>
            <end position="230"/>
        </location>
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            <begin position="449"/>
            <end position="459"/>
        </location>
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        <location>
            <begin position="486"/>
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        </location>
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        <location>
            <begin position="535"/>
            <end position="555"/>
        </location>
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        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3310330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="621" mass="67810" checksum="2D76F69532B4A27F" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H2P6</accession>
    <name>A0AAJ0H2P6_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_518472</name>
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    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_062868361.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87887190"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3310410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="155" mass="17120" checksum="3D95D7ED52209EDE" modified="2024-07-24" version="1">MSNETRRGVLRLFIPGEPRKTKAAILGCYFLGVLRIFQLLGFIKVELYMSSCPAMTDGLGSPYYQAAAASPRSLLPPPLTALATNCILCKYDWDFGWLSGSLRLLILWYLPLYIRFANPMSTSSPASTISMYMCDGSTALNRHRLGHVVYAAASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H440</accession>
    <name>A0AAJ0H440_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Autophagy-related protein 29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_72788</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Plays a role in autophagy. Functions at the preautophagosomal structure (PAS) in order to form normal autophagosomes under starvation conditions. Also plays a role in mitophagy and regulation of filamentous growth.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATG29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727162.1">
        <property type="nucleotide sequence ID" value="XM_062871257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H440"/>
    <dbReference type="GeneID" id="87890086"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2570:FF:000001">
        <property type="entry name" value="Autophagy-related protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039113">
        <property type="entry name" value="ATG29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040666">
        <property type="entry name" value="Atg29_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039362">
        <property type="entry name" value="ATG29_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40012">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40012:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18388">
        <property type="entry name" value="ATG29_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Atg29 N-terminal" evidence="9">
        <location>
            <begin position="30"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="114"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="153"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="235"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="252"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="281"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="295"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="374"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="456"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00060351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3311382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="516" mass="55058" checksum="CF121097BFE3DE96" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H4C6</accession>
    <name>A0AAJ0H4C6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RTA1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_79781</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727341.1">
        <property type="nucleotide sequence ID" value="XM_062871328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H4C6"/>
    <dbReference type="GeneID" id="87890157"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF34">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00480)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3311561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="353" mass="39604" checksum="138126E445B8EA4B" modified="2024-07-24" version="1">MAAGEPIRLSLYIYAPNKGAPIFFAIAYFISAVFHIWQCYRYKAWRLIGLHPVCALLFTVGYALREYGAYNYLFSTTTKVPLSIFIVSQIFIYICPPLLELANYHVLGRVFYYVPYCSPLPPNRVLSTFGGLMMLVEVLNSLGVSLAANTSGKASTQKIGSSLTIAAVSIQLLVILMFFSLAAVFHHRCANKAQIRAANVYTLLTTLYLSMALILVRCIYRLAEHTVGPHKIEINNLEALRQLSPLLRYEVFFYVFEASLMLVNSLLWNVWHPGRLVASDNRVYLARDGTEAYRDEDEDKRPLFAKTANMFTFGLLFRRKGSAERFHQLDEYSSVAGGSRGEDGGESGAGPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H4F1</accession>
    <name>A0AAJ0H4F1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chitin biosynthesis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_571736</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727135.1">
        <property type="nucleotide sequence ID" value="XM_062870869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H4F1"/>
    <dbReference type="GeneID" id="87889698"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034044">
        <property type="term" value="C:exomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000747">
        <property type="term" value="P:conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17742">
        <property type="entry name" value="BRCT_CHS5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000453">
        <property type="entry name" value="Chitin biosynthesis protein CHS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.120.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031673">
        <property type="entry name" value="Chs5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052827">
        <property type="entry name" value="CHS_Export/Cell_Fusion_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031669">
        <property type="entry name" value="Fn3_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47351">
        <property type="entry name" value="CHITIN BIOSYNTHESIS PROTEIN CHS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47351:SF1">
        <property type="entry name" value="CHITIN BIOSYNTHESIS PROTEIN CHS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16892">
        <property type="entry name" value="CHS5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16893">
        <property type="entry name" value="fn3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="129"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="217"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="317"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3311355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="449" mass="48040" checksum="2CFD7B2E68A0D3AF" modified="2024-07-24" version="1">MVGFINAKAMLGGDKGSSTEPKRQTCDRSPTSSGNLASSYQAAASTRATSRMRTGHTTAYPESMLVSLTVGKVDAGVTIEFPSILLPPDITSGSIVDINVARNKNSESEAERAFRELQDQILSSFGSVEPSPPVLRCRNATQTSVVLEWDPIQLATADLISLALYRNGQKAGNIPKPLSMHTTKISGLAVDTEYTFHLVLRTTAGTFSSQRVTVRTHKMTDLSGITITTGILPAAVRESLTAAVERIGAKIVDGVRIDTTHFVTTEGRGVQWEKANELNIPIVRPEWVEACERNGRILGVTKFYLDAVRPPFEERPGTAGTTSTTTAAPASAPAPPPPEKDAPRNHARTTSTASQIAEPTPEEVAGQEKEGDAELESSGTEEEESQKAISGGQDEQKVLADERDQNRLAARPKPTVEDEDETQENKAASEDEKGGKSPGDGSSFQDVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H4K8</accession>
    <name>A0AAJ0H4K8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cupin type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_388820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727461.1">
        <property type="nucleotide sequence ID" value="XM_062864460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H4K8"/>
    <dbReference type="GeneID" id="87883289"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02231">
        <property type="entry name" value="cupin_BLL6423-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047142">
        <property type="entry name" value="OryJ/VirC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36156:SF2">
        <property type="entry name" value="CUPIN TYPE-2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36156">
        <property type="entry name" value="SLR2101 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="2">
        <location>
            <begin position="121"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3311681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="226" mass="23868" checksum="3CAE43E6D160F562" modified="2024-07-24" version="1">MSNPNSDSSSPPSTNTNPASSDHSKCPFGSPNRYTTTHDTTTHNAIFFPSDSTTLPSPIPSYTAGGMVVHDAWSTTTTTHPSSRLSFTSDADISSSPHLLPPPPTRSIWFPSPGETLLRYCDWPPGATLPLHRTETLDLGVCVAGSMELTLDSGQTRTLRVGDVVVQRGTMHAWRNASGTEWARVVFFLAGAEAVDVGGGGVVMREVLPWAASGGGGGSESDIVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H4M3</accession>
    <name>A0AAJ0H4M3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histidine phosphatase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_387846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727269.1">
        <property type="nucleotide sequence ID" value="XM_062864408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H4M3"/>
    <dbReference type="GeneID" id="87883237"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050278">
        <property type="term" value="F:sedoheptulose-bisphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046390">
        <property type="term" value="P:ribose phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000022">
        <property type="entry name" value="Phosphoglycerate mutase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF15">
        <property type="entry name" value="SEDOHEPTULOSE 1,7-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="23"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3311489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="268" mass="30050" checksum="8B7EF256956619A9" modified="2024-07-24" version="1">MSSPRVFIVRHGETEWSLDGRHTGSTDIPLTANGEKRVLATGKALVGNDRLIAPSKLAHIYVSPRRRAQRTLELLNLVQRHQLPWEAHGEPYCEHLQCGAQVEVTEDIREWDYGDYEGITSPEIRELRKQQGLDPNWDIWRDGCPGGESPSDINERLDRLIKEIREKWHAPVMDKPTGQGGNGDVLIVAHGHILRAFAQRWAGQSLHGGPSFLLEAGGVGTLSYEHHNINEPAILLGGAFVVDLPGMLTPRIRRGILSLILRFFLHTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H4Z1</accession>
    <name>A0AAJ0H4Z1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_521904</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDSL' lipolytic enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727360.1">
        <property type="nucleotide sequence ID" value="XM_062868588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H4Z1"/>
    <dbReference type="GeneID" id="87887417"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037459">
        <property type="entry name" value="RhgT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695:SF1">
        <property type="entry name" value="RHAMNOGALACTURONAN ACETYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042521327" evidence="4">
        <location>
            <begin position="20"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3311580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="264" mass="27989" checksum="095EAEA30A8196E0" modified="2024-07-24" version="1">MLPWSTLLVAGFAAAGAHGSPVEVCRRATPTVYLAGDSTTAKTGNGLMGWGEYLPKYLTVPVVNKAVAGRSARSYTNEGRFSELTNLVKRDDIVVIEFGHNDGGSPNSANDNGRSDCPGTGDEVCRSGKTGETVYTFNHYIETAARALVAKGARVIVSSQTPNNMWEGGQYNPAPPRFVAYAALAARNVGAPGATFVDHFQSVANMYRKLGSAKTNALYPKDHTHTSPEGADLVAQAFVQAVGRDLNGTTPLKGFLKSPVPVVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H4Z3</accession>
    <name>A0AAJ0H4Z3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">NAD(P)H-hydrate epimerase</fullName>
            <ecNumber evidence="3 10">5.1.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">NAD(P)HX epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0T15DRAFT_82371</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>(6R)-NADHX = (6S)-NADHX</text>
            <dbReference type="Rhea" id="RHEA:32215"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:64075"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 10">
            <text>(6R)-NADPHX = (6S)-NADPHX</text>
            <dbReference type="Rhea" id="RHEA:32227"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:64077"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="10">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.99.6" evidence="3 10"/>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727449.1">
        <property type="nucleotide sequence ID" value="XM_062871357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H4Z3"/>
    <dbReference type="GeneID" id="87890186"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052856">
        <property type="term" value="F:NAD(P)HX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10260:FF:000005">
        <property type="entry name" value="NAD(P)H-hydrate epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="entry name" value="YjeF N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01966">
        <property type="entry name" value="NADHX_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032976">
        <property type="entry name" value="YJEFN_prot_NAXE-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00197">
        <property type="entry name" value="yjeF_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13232">
        <property type="entry name" value="NAD(P)H-HYDRATE EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13232:SF10">
        <property type="entry name" value="NAD(P)H-HYDRATE EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="YjeF N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 10" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF N-terminal" evidence="11">
        <location>
            <begin position="11"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="61"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="127"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3311669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="236" mass="25535" checksum="45FBFAAD785BA421" modified="2024-07-24" version="1">MALKTLGAKAAAALDKELMSTGAFSLDQLMELAGLSVSQVVYRVHPVSKGRRVLVAVGPGNNGGDGLVAARHLRHYGYQPTIYYPKRPKNELYQRLAKQLEDLDVPFVDDFPVALQSTDHVVDAIFGFSFSGEVREPFPAVIQAMAETKLPVTSVDAPSSWDIEEGPPKSGVGSNFHPDVLVSLTAPKPLVKHFRGRHFIGGRFVAPAIAKKYGFDVPAYEGLDQIVEVGPDGLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LXX1</accession>
    <name>A0AAJ0LXX1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_544389</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717480.1">
        <property type="nucleotide sequence ID" value="XM_062870065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LXX1"/>
    <dbReference type="GeneID" id="87888894"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3301700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="149" mass="15836" checksum="38AE36B2A3BAD920" modified="2024-07-24" version="1">MADQEDPIHHITSLSSLAPLSSTHKYLILDFTAQWCPPCKAIAPLFSRLAKESAVPNVLAFAKVDVDEAPDVAQKFGVTAMPTFLFLVDGEPKGVPVEAVAAVPSVSKDDEGRVVQIRGADPRSLVAVVQEVARLAKEEAEGGGEEKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LXZ5</accession>
    <name>A0AAJ0LXZ5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_515051</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717584.1">
        <property type="nucleotide sequence ID" value="XM_062868156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LXZ5"/>
    <dbReference type="GeneID" id="87886985"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18621">
        <property type="entry name" value="GH32_XdINV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800">
        <property type="entry name" value="EXOINULINASE INUD (AFU_ORTHOLOGUE AFUA_5G00480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800:SF3">
        <property type="entry name" value="GLYCOSYL HYDROLASE FAMILY 32 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 32 N-terminal" evidence="5">
        <location>
            <begin position="18"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="412"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="427"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3301804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="459" mass="51035" checksum="B4DE1B3DFC0D667E" modified="2024-07-24" version="1">MDLTSRSKQQPHPKPRMHFTANSWINDPCAPGYDPHTKLYHLFYQCNPTGCEWGNMSWGHIVSRDMVSWTQADVSPALIPDQPYDAQGVFTGCWIPPIDDESGNTLWVAYSSVKHLPFHWTTPPYPRNAAGLAIASSRDGGRTWTKSARNPMVAGEPGGLKVTGFRDPFVTELPLISNTSDRGCVLYGLVSGGIQDSGPTVFLYEIHRDNPEQEWRYLGPLVELPSRFQPSEKWSGNFGVNWECANLVALRAGPDVRHFLVMGAEGDVEKEHVRSYQRPATAPSRTVRAQLWMSGRLLPPASGDGVRFQYESGGYLDHGPYYAANSFMDPQSGRTIVHGWNPEEDLTLGAAAKKGWNGSLAIPREIFLLRIPKVVGALRSALQDISPFELITEEDRTTTVLTLAYPPLPYRNQTPSHAGPFARQRPQAGNSRRPLQSTRDVKKSAFTCATMMISPFAPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZ41</accession>
    <name>A0AAJ0LZ41_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_538796</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718784.1">
        <property type="nucleotide sequence ID" value="XM_062869701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZ41"/>
    <dbReference type="GeneID" id="87888530"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3303004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="583" mass="64323" checksum="9F06D09011199390" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZD1</accession>
    <name>A0AAJ0LZD1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_266062</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718963.1">
        <property type="nucleotide sequence ID" value="XM_062863405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZD1"/>
    <dbReference type="GeneID" id="87882234"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF148">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3303183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="307" mass="33811" checksum="F708B3C81510D3D5" modified="2024-07-24" version="1">MTAVAKTIVATGASSGIGFELVKQLLFQPSTTPYRFILGARDVARTQAAYDALRYDSARHSLTVLPLELSDLRATRSFAQLTLQRLRDEGHNGGLDYLLLNAAVTNPAGANLKGQEEGKGEFGEKGWCESFVVNHLSQHYLVHLLREKLVESKARIVVVSSGAIRRVQQTDSLDSDLKAGSGADGQTTYSQTKFVQLLGAHWWRRQLKGQCTVVAVSPGLIPDTGIGRGSGMKLTMDMPDAKTVPEGAQSIFRAFTRDIPEDPDQIFLTSWGEWWSKDVYALSLDKALQDKWCPSKEEIERKNGLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZL0</accession>
    <name>A0AAJ0LZL0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_513703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719321.1">
        <property type="nucleotide sequence ID" value="XM_062868061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZL0"/>
    <dbReference type="GeneID" id="87886890"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3303541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="358" mass="38023" checksum="579683643145BD22" modified="2024-07-24" version="1">MSQAPCFPSGGGLPAAEPLRGPVLSSDSGQAPSAPHALPQKTPGRQRPERPLRSRLLQRLEASLAVDPDKEVILPVLVVGADLRQHALLARFSQLYELSLVTDAAVRFLGFEPLSLPAGVLKPFSCPLGRINPVRYVGLVVEQARNNLSQTTIGHVIVLDGRFNDRGPDLYLGRRFLQDVFDGGLPPKAAYAVGGAGQQSNLPNPMSLGQFGNPNPPSWTPVMPVGTAAQQFWGQTQMPSWPGQGGGSSSLSYAQPSEGFPVANQTSVLPAPQIPMAGNTGALLYYAQAAGGAYPYEFPQSTQTPEEQHAPGPGGQEMPLWNASNIVSNQLLFASPPPPPPPQDFDPSFGINGDREVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZL7</accession>
    <name>A0AAJ0LZL7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Chromatin structure-remodeling complex subunit rsc9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_540479</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
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        <location>
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        <location>
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        <location>
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            <end position="938"/>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="EMBL" id="KAK3303530.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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        </alternativeName>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
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        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_062869793.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0005832">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="TCP1_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="T-complex protein 1 subunit delta"/>
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    </dbReference>
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        <property type="entry name" value="T-complex protein 1 subunit epsilon"/>
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    </dbReference>
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        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Chap_CCT_epsi"/>
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        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
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        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="GROEL-like_equatorial_sf"/>
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        <property type="entry name" value="TCP-1_chaperonin"/>
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        <property type="entry name" value="thermosome_alpha"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TCOMPLEXTCP1"/>
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        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
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    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3303545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="550" mass="59701" checksum="123E5460649E13F1" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ0M008_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">IMS import disulfide relay-system CHCH-CHCH-like Cx9C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_535154</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3303976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719756.1">
        <property type="nucleotide sequence ID" value="XM_062869482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M008"/>
    <dbReference type="GeneID" id="87888311"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034595">
        <property type="entry name" value="NDUFAF8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34561">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34561:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3303976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="61" mass="6826" checksum="BA1CEC27FB035616" modified="2024-07-24" version="1">MQPKPRPIQRFAQAVSKCSAEAAVYGQCIVADYNSVHKDKCAKEFMKLKDCYLQAMSKGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M097</accession>
    <name>A0AAJ0M097_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_233603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720015.1">
        <property type="nucleotide sequence ID" value="XM_062862980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M097"/>
    <dbReference type="GeneID" id="87881809"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042495894" description="Secreted protein" evidence="1">
        <location>
            <begin position="38"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3304235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="114" mass="13114" checksum="6343E3B5BFA4296D" modified="2024-07-24" version="1">MLRIHRHRPRIFGRPLLSAPAFAWLLQHAVLLPSGRSQTERAYRRCSMRTRLPGQLRTMPRILWHIGRPAGSRKFRAPTFVVTSALDERRCLGMRLASGRLFTCLLRPRLGSGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M0S3</accession>
    <name>A0AAJ0M0S3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FMN-dependent dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_486278</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
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                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720537.1">
        <property type="nucleotide sequence ID" value="XM_062866344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M0S3"/>
    <dbReference type="GeneID" id="87885173"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF75">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE (AFU_ORTHOLOGUE AFUA_4G07050)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN-dependent dehydrogenase" evidence="2">
        <location>
            <begin position="27"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="FMN-dependent dehydrogenase" evidence="2">
        <location>
            <begin position="213"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3304757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="283" mass="31083" checksum="8C21B3E2F17D6668" modified="2024-07-24" version="1">MLVDTNARDTATATTTLFFGGTQKHRGHSHSHKVVAAPIGFAHVGHQQDLPPRHGKLAVARAPRAELKLAPIESVPEANGAGASGGVRFFQLYMPHDDELTVRVLFLTVDTWQLGWRHDDVATSNYAFYHGIGAELGLSDPVFQKRLKEKSIDPVKQPDEAGALWIDNVWHGRAHTWEKVKWVMGDAKRAVEIGCDGIVVSNHAGRHTSYSISGIRGASDVFKALALGAKFVFHGVRHVMKSLLADFDILLNVAGFQSVDQIDRTALESYPRGYPLLPEKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M0X3</accession>
    <name>A0AAJ0M0X3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_255867</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720701.1">
        <property type="nucleotide sequence ID" value="XM_062863245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M0X3"/>
    <dbReference type="GeneID" id="87882074"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042469513" description="Secreted protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3304921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="95" mass="10553" checksum="4E8F9E5C2129CB56" modified="2024-07-24" version="1">MLHAFLISIACLPLSRHFHTVHALTRQLTYQALRPYGVAIFRPSRFASLSAIALADDRSSLRLVNVGALTVSPCSRPVCTSTLCRRVSRNQCRTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M152</accession>
    <name>A0AAJ0M152_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_190249</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720941.1">
        <property type="nucleotide sequence ID" value="XM_062862434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M152"/>
    <dbReference type="GeneID" id="87881263"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042580506" evidence="3">
        <location>
            <begin position="20"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="345"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="293"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3305161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="431" mass="44937" checksum="1817AFEBE222CB4D" modified="2024-07-24" version="1">MSAFNLLLILLFLVHLVASDSDHCYLPNGQLAESAASCWDPAVGPTGLCCRQGDLCLNNSLCQHGSGALYRGFCLDSTWSSPGCPNFCVQPGQQNDSQPVVRCKDVDRWYCAPGGLSNEHLCEVVDDKVDGLFVVADNFSVYATAGTQPNPLFLRDSAEGNPHTTDPVTSEDSPTAKDTPTAKDSPTAKDSPTPKDSPTAKDSPTAKDAPTAKDSTEDHRPASTSPPSVTQTPSVSLPTGVYISIPTQSSPGPVSTDASITSIDVPKSKHSSSGPGGVSISIPTQSSPEAHTTDTATLPTPATRSDSDVAGQSSPTATASEAVPGTESPTAADSKTSPDDGKASLAVPIGVGVGIGTSVVVAASVFGFFYMRKRRRQAPVRAETPPPFEFPLVNDQGRGWPGPPYGTRLPPMRTCNTYVPELGGCARYELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M1W0</accession>
    <name>A0AAJ0M1W0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_502968</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062867452.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87886281"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SET domain"/>
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    </dbReference>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SET_dom"/>
    </dbReference>
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        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053185">
        <property type="entry name" value="SET_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332:SF6">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042559040" description="SET domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="3">
        <location>
            <begin position="133"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3305945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="457" mass="50904" checksum="10ABBCC3A53B47ED" modified="2024-07-24" version="1">MRSHLTLHLTLLILPTLSLSSQTSEPSQCASPAPSRPLHSHLTDITAPSCLDSHISPSQPSAWHPWTHQPYCIPASDTPWCVFTDAAHGISVITTPEEAADALHPHTHLVFGDDDDDDELLLFFEPDKVMKPRPYEVREIPGKGKGAVATRRIEKGKVMLVDTVSVLAAVEYPADVLREEVQDLLRVAAERLGEPGRVTGLAKQGVKGRVMGRRRSGGTEEHEQEQEGEDEEEEDGVQEMSEMEDVMLTNSFGVTVGGKEYMGLFADLARFNHACKPNAFIHFSETKLAMTVWSAQDIEPGEEITISYANAGMTSQERQQLLEQIWGFQCQCSLCTASPAARNASDSRRIEIRHLQDEVVSLAQNGEFDTAIEQAERLFSLVDEEGLTEQMSGMYEVPARLYYHVGNLEKALQYTLKVRHEIDGYAVPSKQGREKLEMLDGVIARIERELREKREGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M2B0</accession>
    <name>A0AAJ0M2B0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_527335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722261.1">
        <property type="nucleotide sequence ID" value="XM_062868966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M2B0"/>
    <dbReference type="GeneID" id="87887795"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3306481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="243" mass="27366" checksum="B3F9AF8CF2DB1FEB" modified="2024-07-24" version="1">MAARASSFSRPLRQRLALLSQFVLGCPIVGFSALYLWTSRCRFEPFGPENSTLFRHPILKTINPRNNPSSNDCCVRAVPLAQVRPELLEDARRGGARMVETFCAGMWGGYGYGIQRNIMRMTKDGSNINDLWTKQELLRDSYEPGTVITNHFLVLDKTPSTLTFRGCLGPKQLPPTPQELDNIFELSATVDEKNQRVEFRLKCITFDGTDLTGREDPYGGFPGFLHRQYAKLLVEAAVSNCVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M2Q1</accession>
    <name>A0AAJ0M2Q1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_151865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722533.1">
        <property type="nucleotide sequence ID" value="XM_062862006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M2Q1"/>
    <dbReference type="GeneID" id="87880835"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3306753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="63" mass="7020" checksum="FEE7D2DA4F2C5066" modified="2024-07-24" version="1">MPSNPMPEGTKDPSSRSEAKQQMKQEEKEARKEHSKSGANTGEKQGMDYVPRKTHAADVPHNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M3Q2</accession>
    <name>A0AAJ0M3Q2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6603 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_490449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3307833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723613.1">
        <property type="nucleotide sequence ID" value="XM_062866680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M3Q2"/>
    <dbReference type="GeneID" id="87885509"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046538">
        <property type="entry name" value="DUF6603"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20248">
        <property type="entry name" value="DUF6603"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6603" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6603" evidence="1">
        <location>
            <begin position="98"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6603" evidence="1">
        <location>
            <begin position="182"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3307833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="295" mass="30851" checksum="4D568EE00909DD53" modified="2024-07-24" version="1">MGAYRQTKSADFRSVFVYGRLNGPLFTISFAEVSGVAVSSGYNYTSHSPSAADVETFPLLSRQGPAEVGANSNPLDMIIGNSPSSFSSWLQAEEGMLKASLIGRATAQMPPAANKSPVTFVYAELGIVASIDSTSFVVKSQLSSNSFVLTPLCRIRGGFALAFWSYRTGSASAAKATLPSPPKAVIGGAYMIATFNTGLIYADFEAWVLFLLNHKPLFFVTEVGLSITVGACINMGFICIDINGTVNADLPKALIFDEFADAVAKPALTGVEGTKGADKAALVVVALSAGAITDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M3R6</accession>
    <name>A0AAJ0M3R6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_572218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3307951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723731.1">
        <property type="nucleotide sequence ID" value="XM_062870886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M3R6"/>
    <dbReference type="GeneID" id="87889715"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoribulokinase/uridine kinase" evidence="1">
        <location>
            <begin position="26"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3307951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="238" mass="26403" checksum="B4FE75F231E39AD7" modified="2024-07-24" version="1">MDLALDRLVGEAWSGFLETPKNMRYLIAIGGIPGSGKTTLSKRLTAALNARHAAQFPDQPQPVAAFVPMDGYHLTRAQLDAMPDPATAHARRGAEFTFDGERFYGLVQRLREPLTDKTGTVWAPSFDHAIKDPKEDDIAVERTHRIVVLEGNYLLLNKPPWRQASQLASLKIFVSVSPDLARKRLVARHLAAGLCATPEEADRRAVENDLPNGEEIVRLRIEDVDDVVESREDGSWSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M3X8</accession>
    <name>A0AAJ0M3X8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PRELI-like family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_97748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723882.1">
        <property type="nucleotide sequence ID" value="XM_062871508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M3X8"/>
    <dbReference type="GeneID" id="87890337"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006797">
        <property type="entry name" value="PRELI/MSF1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037365">
        <property type="entry name" value="Slowmo/Ups"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11158">
        <property type="entry name" value="MSF1/PX19 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04707">
        <property type="entry name" value="PRELI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50904">
        <property type="entry name" value="PRELI_MSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRELI/MSF1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3308102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="238" mass="26415" checksum="8C867E311EA1DE5E" modified="2024-07-24" version="1">MVLTHTTNHTYSHPFPTVTLAFFLRYCSPQLNPFASHVLSTDTIESRVDPVTGRLHTTRIHLKKSRLPPAVMKLLPSSLTGGTSDKASYILETSVVDMREGWMQTESRNLNFVGVLSVVERQLYTVPKNKPAVENTEVETKVVFRSRLGDRIRDRLGQAQAQAEAAANDGGGGFFARLGARGVQRSIETLASTKTQDQLGKSREGMRIILERLRQTGIMGVLELRKMASQRSSEAVPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M3Y2</accession>
    <name>A0AAJ0M3Y2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">asparaginase</fullName>
            <ecNumber evidence="1">3.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_508649</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the asparaginase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.1" evidence="1"/>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723930.1">
        <property type="nucleotide sequence ID" value="XM_062867738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M3Y2"/>
    <dbReference type="GeneID" id="87886567"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009066">
        <property type="term" value="P:aspartate family amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08963">
        <property type="entry name" value="L-asparaginase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1170:FF:000003">
        <property type="entry name" value="60 kDa lysophospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.40:FF:000001">
        <property type="entry name" value="L-asparaginase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1170">
        <property type="entry name" value="L-asparaginase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036152">
        <property type="entry name" value="Asp/glu_Ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006034">
        <property type="entry name" value="Asparaginase/glutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040919">
        <property type="entry name" value="Asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027473">
        <property type="entry name" value="L-asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041725">
        <property type="entry name" value="L-asparaginase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027474">
        <property type="entry name" value="L-asparaginase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037152">
        <property type="entry name" value="L-asparaginase_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707:SF28">
        <property type="entry name" value="60 KDA LYSOPHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00710">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17763">
        <property type="entry name" value="Asparaginase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001220">
        <property type="entry name" value="L-ASNase_gatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500176">
        <property type="entry name" value="L_ASNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00139">
        <property type="entry name" value="ASNGLNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00057">
        <property type="entry name" value="Glutaminase/Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00870">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53774">
        <property type="entry name" value="Glutaminase/Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51732">
        <property type="entry name" value="ASN_GLN_ASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="L-asparaginase N-terminal" evidence="8">
        <location>
            <begin position="20"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Asparaginase/glutaminase C-terminal" evidence="9">
        <location>
            <begin position="258"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="443"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="476"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="511"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="541"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3308150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="660" mass="71043" checksum="054F37210805E6EC" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M427</accession>
    <name>A0AAJ0M427_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Homoserine kinase</fullName>
            <ecNumber evidence="3">2.7.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B0T15DRAFT_523219</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Commits homoserine to the threonine biosynthesis pathway by catalyzing its O-phosphorylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-homoserine + ATP = O-phospho-L-homoserine + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.39"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:13986"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GHMP kinase family. Homoserine kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.39" evidence="3"/>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3307999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723779.1">
        <property type="nucleotide sequence ID" value="XM_062868675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M427"/>
    <dbReference type="GeneID" id="87887504"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004413">
        <property type="term" value="F:homoserine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000068">
        <property type="entry name" value="Homoserine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00384">
        <property type="entry name" value="Homoser_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000870">
        <property type="entry name" value="Homoserine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00191">
        <property type="entry name" value="thrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20861:SF1">
        <property type="entry name" value="HOMOSERINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20861">
        <property type="entry name" value="HOMOSERINE/4-DIPHOSPHOCYTIDYL-2-C-METHYL-D-ERYTHRITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000676">
        <property type="entry name" value="Homoser_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00958">
        <property type="entry name" value="HOMSERKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="11" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="12" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="7" id="KW-0791">Threonine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="16">
        <location>
            <begin position="74"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="17">
        <location>
            <begin position="272"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007370"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3307999.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="358" mass="38529" checksum="AABB4C7B38D9003E" modified="2024-07-24" version="1">MASATESFTIKTPCSSANIGPGFDVIGLALSMYLELQVTIDRTKTKSEHPLNCRITYEGEGEGTDEISLDPQVNLLTRVALYVLRCHDQRSFPVETHVHIKNPIPLGRGLGSSGAAVVAGVMLGKECGGLHHLTPERLFDFCLMIERHPDNVGAALFGGFVGTYLKPLAPEDVARVEIPLSEVLPAPAGGVDTGAKPPAPPHGIGHHIKFPWAPEIKAVAIIPEFEVPTAKAREVLPLQYPRPDVTFNLQRIALLPVALGQSPPDPELIYLAMQDKLHQPYRQTLIPGLTEIVESMTPATQPGLLGVCLSGAGPTILALATGHFGEIADRIIAKFEENKIVCNWKVLEPAEGTQVIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M4S5</accession>
    <name>A0AAJ0M4S5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_551122</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GeneID" id="87889095"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:clathrin coat disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="putative tyrosine-protein phosphatase auxilin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UBA domain-containing protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
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    </dbReference>
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        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23172">
        <property type="entry name" value="AUXILIN/CYCLIN G-ASSOCIATED KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23172:SF19">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="287"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
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        </location>
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        <location>
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        </location>
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            <begin position="20"/>
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        </location>
    </feature>
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        </location>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3308780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="908" mass="96865" checksum="8183E03FE8DBCC21" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M581</accession>
    <name>A0AAJ0M581_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Xylose isomerase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_756</name>
    </gene>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725114.1">
        <property type="nucleotide sequence ID" value="XM_062871286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M581"/>
    <dbReference type="GeneID" id="87890115"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050312">
        <property type="entry name" value="IolE/XylAMocC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110:SF56">
        <property type="entry name" value="DEHYDRATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08740)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110">
        <property type="entry name" value="HYDROXYPYRUVATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="2">
        <location>
            <begin position="32"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3309334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="355" mass="39164" checksum="DEA2E2C8B5070911" modified="2024-07-24" version="1">MSQNLNRAPSHLPVAFASCSIGLPRHTLHQKVEAIREAGFDGIELSFPDLQAYASRHFGRDIAADDYGSLCEAAKAVGRMVAGHGLKILVLQPFANFEGWPRGSAQRREAFARAEAWIDIMEAAGTDMLQVGSSDSPDMSRDVDQLAADLACLADMLAARGFRLAYENWCWATRAPRWRDVWDIVQKADRPNLGLCLDTFQTAGSEWADPTTKSGRIEAAGGITTVEEELCEAYAASLEGLATTVPADKIFFLQISDAYRPDPPLGEEADPESGLRPRGRWSHDQRPLPYDGGYLPAPIKQFVRAVLATGFKGWCSIEVFDGRFEEKYGDDLRKFARRGMQAYQRLLSEATAEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M594</accession>
    <name>A0AAJ0M594_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_515349</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725159.1">
        <property type="nucleotide sequence ID" value="XM_062868183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M594"/>
    <dbReference type="GeneID" id="87887012"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042577434" evidence="1">
        <location>
            <begin position="22"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="73"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3309379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="341" mass="37966" checksum="9FD9C752F245DDE1" modified="2024-07-24" version="1">MDFTILIPAFLYLLLAHQAQAGGYTPPYMTLPAPPSLPDAVATGYVNLSDGVDIWYAHFGPTLEESFARGRAPVLFLHGAHASSDYWGHQIRYLLSQNDPRTILAIDSRLMGRSTYGDMTTSFARKAADAIAVLDHFHIPQAAVVGWSNGAAVLINLLLDYPSRVERAFVFAGWYDASTSLNQTTGTAQYNATSAVYFNRTLEELMRLSVHPELVPAARQAYYEEYMREPHWDSTDFARIPTGLDNCQDSPLVWYVEAAEEEVINRGVAGIMHKWTPGSTLWVLPNVSHWALLQDPVAFNDVLHRFLEDPRHCGLWGATCLNPGFAQQLQDRGPGFPLVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M597</accession>
    <name>A0AAJ0M597_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_2115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725174.1">
        <property type="nucleotide sequence ID" value="XM_062862679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M597"/>
    <dbReference type="GeneID" id="87881508"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042605960" evidence="1">
        <location>
            <begin position="21"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3309394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="453" mass="48719" checksum="2FF8A6722589AC95" modified="2024-07-24" version="1">MPVNLAFFVLLLLQATLSLSLTSSRTNPLPFQHVRKPIFAPLPIDKHGSITDQPSRPAFQPGKAYTYNLSLNTTSELYSYNYQHDSDTGSGIADADSSGFSAAVASNLTILTQADSPEPGTLIFLAYVSVPDCLVEAGNPIGESGLRVIRNTFGTDQECVKRSEGVDNQTSVWVTQDLTSGEFKNVYYNASVTYDPDSQSQDPLGYHKLILSSLRTLQSYYNGSESYEHETTDRFGNPRTVKYQYIGKLADSQCWQADSQSINGDELAADTKNVCWSPAGGVSAMTGGDATELGTTHGAAEIVDKVTVSSGLYATLSQNGTLEVLQSGIPTLVNYSSCSGPFSDIQQGQSANLDPILLALNPSGQVCRFAWSGSGTPQIEVDTSPPFSGLAGGPPVELPGQYRSQWALDTFGAIWETHDTSPNSPSSPITWTNYTDPGSVNDAFRPILVRQML</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M5U7</accession>
    <name>A0AAJ0M5U7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="6">PPIase</shortName>
            <ecNumber evidence="6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_517725</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cyclophilin-type PPIase family. PPIase H subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="6"/>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725981.1">
        <property type="nucleotide sequence ID" value="XM_062868323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M5U7"/>
    <dbReference type="GeneID" id="87887152"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000035">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="7">
        <location>
            <begin position="15"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3310201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="182" mass="19965" checksum="F9B97B6CAAA03E5E" modified="2024-07-24" version="1">MAPTKLPESGNPLVFFDITLGGEPLGRVTFELFKDVVPRTAENFRQFCTGEHRNNLGRPQGYKGSKFHRIIPNFMCQGGDFLNGDGTGSTCIYGTKSFADENFTLKHDQPGLLSMANAGPNTNGSQFFITTVPTPFLDGKHVVFGKVVDGMDIVRKMEHTKTGYRGKDVPNLDVVIAQCGEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M632</accession>
    <name>A0AAJ0M632_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Armadillo-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_31269</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726044.1">
        <property type="nucleotide sequence ID" value="XM_062863948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M632"/>
    <dbReference type="GeneID" id="87882777"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000362">
        <property type="entry name" value="Importin 11, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058669">
        <property type="entry name" value="TPR_IPO7/11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF7">
        <property type="entry name" value="IMPORTIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25758">
        <property type="entry name" value="TPR_IPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="5">
        <location>
            <begin position="38"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3310264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1049" mass="118491" checksum="32BB05EF230FC4EC" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M6V3</accession>
    <name>A0AAJ0M6V3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Reactive mitochondrial oxygen species modulator 1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_387416</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MGR2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062864383.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87883212"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Romo1/Mgr2"/>
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        <property type="entry name" value="REACTIVE OXYGEN SPECIES MODULATOR 1"/>
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        <property type="entry name" value="REACTIVE OXYGEN SPECIES MODULATOR 1"/>
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    </dbReference>
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        <property type="entry name" value="Romo1"/>
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    </dbReference>
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    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3310997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="117" mass="12460" checksum="213163165ED5CB29" modified="2024-07-24" version="1">MPPPPSHPGAVGPSNFDKLKMGAMMGGTVGMIIGFIFGTVNIFRYGAGPNGIMRTLGQYMLGSGATFGFFMSIGSVIRSDSSPIVQEAYLRAQRRPIIMASQAFRAPYQTARRPGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ0M6V4_9PEZI</name>
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        </submittedName>
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        <lineage>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726884.1">
        <property type="nucleotide sequence ID" value="XM_062864280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M6V4"/>
    <dbReference type="GeneID" id="87883109"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044398">
        <property type="entry name" value="Globin-sensor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039379">
        <property type="entry name" value="Protoglobin_sensor_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42071:SF1">
        <property type="entry name" value="GLOBIN-SENSOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42071">
        <property type="entry name" value="PROTOGLOBIN DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Globin-sensor" evidence="2">
        <location>
            <begin position="22"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3311104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="304" mass="33876" checksum="2C1E158D719C7F6A" modified="2024-07-24" version="1">MSTARSRPMQHIDRKSLYTNLEARIQYLHSFLDFGSGDIDALRSGSKYIQALIPAVVNIVYRKLLQYDITARAFTTRSTSFEGPMDEEPDEMSPQILHRKQFLRAYLKKLCSDPSQMEFWEYLDKVGMMHTGIGRTHPLHIEYVHIGAALAVIQDILSEAILSHPRLHIARKIAIVKALGKVIWIQNDLFAKWYVHDGEEYTEGMDYEALVEREGFMHGKKVLAHDEESISGASDDSPAPQRGEKKDGGDAAAAPSAPVGVCPFTGMTTGMGGLKMQEGTVQDAKPKVKFDEEPKAAEVVVNGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GKW0</accession>
    <name>A0AAJ0GKW0_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_497538</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717604.1">
        <property type="nucleotide sequence ID" value="XM_062867275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GKW0"/>
    <dbReference type="GeneID" id="87886104"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3301824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="59" mass="6230" checksum="A04CE9ABABF91F75" modified="2024-07-24" version="1">MSTMNMRAPGLARKRGAPPGLSIVAPSPQQFATERVIQAANMAQPATLAPALLSTAWRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GL29</accession>
    <name>A0AAJ0GL29_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_403347</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3301911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717691.1">
        <property type="nucleotide sequence ID" value="XM_062865199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GL29"/>
    <dbReference type="GeneID" id="87884028"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42032">
        <property type="entry name" value="YALI0E30679P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42032:SF1">
        <property type="entry name" value="YALI0E30679P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3301911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="426" mass="47316" checksum="2B81380293D59AFD" modified="2024-07-24" version="1">MLQDLACPPSTIDESDTEPTPAPRRHRRRSSAFSAYSFDEVTRDLQEITDPAKAANVRFRRPTWKSWFPIILAAVPPIGGLVFKNGATFFSDVIMLILAAILLKWSVTAPWEWYHSAQEVRVLNEGADLDSQRNSKPSSGLGSSRATSPSRAGRQGMEAREVVDVARAKLRSHERWALLSCFLAPAATTYLLWYVRKTLGSPAGSILSSFNLGAFLIAAEIPTVLHMLKLAMDATLHLQRIVHANPYHIPAVTSDQLEDAISRIEELEARLLSESNDPMKEQQKTQQTRAALARDIRAAIQPQIDALNRAVRRYEKKTSMQELEMEERLWELENRVDDAVAFTAVVAKAANANLWNFLERGVAAMWHIATLPLSVTLQMLGVVALSASRTFTRSGSRKVVGVTGLEEYNGQRRIMSGPSSTLSIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GM93</accession>
    <name>A0AAJ0GM93_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_543136</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718297.1">
        <property type="nucleotide sequence ID" value="XM_062869965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GM93"/>
    <dbReference type="GeneID" id="87888794"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3302517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="73" mass="7887" checksum="7F102767DE526381" modified="2024-07-24" version="1">MLPFIFTAQLTFDLTAGAIRMSFSPQCLQSIPEREVSWICGRRLYGTNLDGGGPGMNAALAEFWTSGSVVSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GME0</accession>
    <name>A0AAJ0GME0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Bacteriocin-protection, YdeI or OmpD-associated-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_487678</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718414.1">
        <property type="nucleotide sequence ID" value="XM_062866455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GME0"/>
    <dbReference type="GeneID" id="87885284"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13376">
        <property type="entry name" value="OmdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3302634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="216" mass="24108" checksum="5A4E9D98AA15B217" modified="2024-07-24" version="1">MTARTNRLASKALQAAKSAPALTPTSAAPVVAPIRLFEDAAAWERWLEANHADTMGLWLKISKKGSAIPSVTYEEALDTALCFGWIDGQKKSHDADHFLQRFTPRRRNSMWSKRNVEKVAALLAAGRMREPGLAEVESAKADGRWERAYSASSVMEVPADLQAALDRNKKAKTFFKGLGKTKQYSFLWRLATTKREETRKKKIEQFVGLLAEGKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GMK4</accession>
    <name>A0AAJ0GMK4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD linked oxidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_313787</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718516.1">
        <property type="nucleotide sequence ID" value="XM_062863961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GMK4"/>
    <dbReference type="GeneID" id="87882790"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042585378" evidence="6">
        <location>
            <begin position="16"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="59"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3302736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="500" mass="54023" checksum="AA016B696F36C4EC" modified="2024-07-24" version="1">MRLSLALTATGAVLAAANTSSPHAKRAALDDCLQSAKVPVSARNSAEWKQDARPFNQRLPYTPAAIAVPTTVEHIQAAVSCAAKVGVKVNAKSGGHSYASFGLGGEDGHLVVELDRMYNVTLDPQTNIATVQPGARLGHIATVLYREGKRAFSHGTCPGVGVGGHSLHGGFGFSSHTHGLAVDWITGASVVLANGSLVTASETENADLFWALRGAGSNFGIVASFRFKTFAAPANLTSYQINLPWSTSSAIVKGWGALQDWLLNGSMPEAMNMRILGNGYQTQLQGLYHGNASALRTAAAPLLTLLNATLSNVREYDWMGAFGEYAYSNDIDITTPSYSAAETFYSKSLVTSALPPTVLQNVADYWITTAKKVSRAWYIIIDLYGGPTSAITKVGPGATAYAFRDPTKHLFLYELYDRSFGSSYPADGFSFLDGWVKAFTQGLDATQWGMYINYADPRLNRSEAQQVYYRQNLARLRRIKRLVDPDQVFYYPQAVEPAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GMS5</accession>
    <name>A0AAJ0GMS5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_562518</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718375.1">
        <property type="nucleotide sequence ID" value="XM_062870580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GMS5"/>
    <dbReference type="GeneID" id="87889409"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3302595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="341" mass="38410" checksum="537E995DBB8481AC" modified="2024-07-24" version="1">MTSHYRPLLPRPGPEIFEMNNDCAQTPVFRKTLTGEILIWLEMAATDASQVYPTPPLDEIPDALPDIETDATSTFTELATPPLYEIPPVLAIDTPQDLATQPLYELPPLPAIDTSEELATQPLDKILDALPNINTNATDTFTELASQPLYELPPLLAIDKSEAFATQPLYGIPPVLATDTSQDPATQPLDEIPPVPCYPKKPILHGPKGLHSWEAFIRRELGGMHLEPLVDCTDEELADLAARCPEEHALNEDIAFLIVARRLGTGIRRRLKNERDYPINHDGSRSPHQTVKELWTHVFALCCPSRDEMWEELRTMTLDRTLHDYINRALWLRRQLLRLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GN10</accession>
    <name>A0AAJ0GN10_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_368310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3302919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718699.1">
        <property type="nucleotide sequence ID" value="XM_062864181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GN10"/>
    <dbReference type="GeneID" id="87883010"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="31"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3302919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="163" mass="17803" checksum="ED5E3557BEB2D6FB" modified="2024-07-24" version="1" fragment="single">VLLDDQVKESLLENVRGFLNPATLEQQRGPYRRCYLFHGPTGTGKTCLALALAGHFDLDVYIVCQPVNDSDLKTLFSRIPPRSIIVLDGAEDANSQPREGTASLSALLDTIDSAGDGHVIIMTTRHIALVDSALIMEPSRVALTAGFGLADKEMIARLFRFTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GNS3</accession>
    <name>A0AAJ0GNS3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="17">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">B0T15DRAFT_271176</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="function">
        <text evidence="16">This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports the calcium to the vacuole and participates in the control of the cytosolic free calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="17"/>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719106.1">
        <property type="nucleotide sequence ID" value="XM_062863459.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87882288"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02081">
        <property type="entry name" value="P-type_ATPase_Ca_PMCA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000028">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000031">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000018">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF369">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 17" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 17" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13 17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 17" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="508"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="551"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1063"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1103"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1142"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1174"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1324"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="21">
        <location>
            <begin position="270"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="19">
        <location>
            <begin position="374"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase C-terminal" evidence="20">
        <location>
            <begin position="1021"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="234"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1267"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1343"/>
            <end position="1428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="116"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="153"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1272"/>
            <end position="1290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00059328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAK3303326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1428" mass="154675" checksum="24581F3EFD522C1F" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GNU6</accession>
    <name>A0AAJ0GNU6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_273768</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719184.1">
        <property type="nucleotide sequence ID" value="XM_062863490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GNU6"/>
    <dbReference type="GeneID" id="87882319"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052099">
        <property type="entry name" value="Regulatory_TF_Diverse"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="3">
        <location>
            <begin position="343"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="49"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="141"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="295"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="407"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="181"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3303404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="459" mass="49540" checksum="2FBE807D0AA3DE58" modified="2024-07-24" version="1">MDSDPLKHLEFFSMPNNQTVNPVDQPFLGRSSAQSSSIWDTAGLEAGLAASPSTAPTSLSLDSVTQPSPLTGLTTMSMSSDLTSRSRPSTQGIQSRPIRPARGPSSRDTHERKRSRLSIDATTPLDSVDYWIDFDKDDGLTSVPEGFEPPSQTVEGKGKGPTTSGPTNPTPQPSGLKQDDFFDDSALDNALSDDDDGFSSINVADQLSKIDTAPPQEVPPREGLYSTPLSWERPQPGIRMDSLIGFHGPSLNEAEQRRLIAIAMNPGPSMGGLGSNINLNFSGLAPGIPMTFGTGLGSSGVGEGPKPVSPPQPPAAPPRPAPPNPPKKQGSVSDKGKEKPKSGDRTAHNDIERKYRTNLKDKIAELRDAVPTLRTISENGGEEEGAQPQRTAKVSKGTVLTKATEYIHFLERRNKQIMQEHRDLSRRLQAFEQLLNATARSSYTMPTYSRTLFDPRGFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GNX1</accession>
    <name>A0AAJ0GNX1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ubiquitin-conjugating enzyme/RWD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_513589</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719181.1">
        <property type="nucleotide sequence ID" value="XM_062868052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GNX1"/>
    <dbReference type="GeneID" id="87886881"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23797">
        <property type="entry name" value="UBCc_UBE2H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000061">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="6">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="149"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="155"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="172"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3303401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="191" mass="21696" checksum="9DECB9D5F6E77D21" modified="2024-07-24" version="1">MASPRRRIETDVMKMLMSDYEVTLVNDNMQEFYVRFKGPAETPFEGGVWKVHVELPDQYPYKSPSIGFVNRIFHPNIDELSGSVCLDVINQTWSPMFDMINIFEVFLPQLLRYPNPSDPLNGEAAALMLREPKSYEQKVKEYVQKYATKNAADEATNETGDEDDLSSVGSYGDDDDNDDDDAQATGQMDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GNY7</accession>
    <name>A0AAJ0GNY7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Enolase C-terminal domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_275223</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719224.1">
        <property type="nucleotide sequence ID" value="XM_062863507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GNY7"/>
    <dbReference type="GeneID" id="87882336"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050023">
        <property type="term" value="F:L-fuconate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03324">
        <property type="entry name" value="rTSbeta_L-fuconate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.120:FF:000007">
        <property type="entry name" value="Mitochondrial enolase superfamily member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034610">
        <property type="entry name" value="L-fuconate_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018110">
        <property type="entry name" value="Mandel_Rmase/mucon_lact_enz_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046945">
        <property type="entry name" value="RHMD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13794">
        <property type="entry name" value="ENOLASE SUPERFAMILY, MANDELATE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13794:SF58">
        <property type="entry name" value="MITOCHONDRIAL ENOLASE SUPERFAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00111">
        <property type="entry name" value="L-fuconate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00270">
        <property type="entry name" value="L-galactonate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00179">
        <property type="entry name" value="mandelate_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00909">
        <property type="entry name" value="MR_MLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mandelate racemase/muconate lactonizing enzyme C-terminal" evidence="5">
        <location>
            <begin position="200"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3303444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="449" mass="50099" checksum="027D57E36D478136" modified="2024-07-24" version="1">MPEITITGWTTRDVRFPTSLDKTGSDAMNAAGDYSSAYCILKTDSSYTGHGMTFTIGRGNDIVCAAINHVAERIKGRTLSSLVAHWGQTWRHLVNDSQLRWIGPEKGVIHLALGAVVNAIWDLWAKVLGKPVWRVVAEMTPEQFVDCIDFRYITDAVTPEEAIAMLKEAEAGKAERMRDAENSRAVPAYTTSAGWLGYGEDKMRALLQETQAKGYKHFKLKVGGNVEQDRRRLTIAREVIGYDKGNVLMVDANQVWSVPEAIEYMKQLAEFKPWFIEEPTSPDDILGHKAVRDALRPYGIGVATGEMCQNRVVFKQLLMSGAIDVCQIDACRMGGVNEVLAVLLMARKYGVPIVPHSGGVGLPEYTQHLSTIDYVVVSGKRSVLEYVDHLHEHFLHPSVIKDGYYQTPTDPGYSVEMKPESMDRYEFPGGDGSWWRSEEAKPILESEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GP94</accession>
    <name>A0AAJ0GP94_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peroxin 20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_513566</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719155.1">
        <property type="nucleotide sequence ID" value="XM_062868048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GP94"/>
    <dbReference type="GeneID" id="87886877"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005052">
        <property type="term" value="F:peroxisome matrix targeting signal-1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024111">
        <property type="entry name" value="PEX5/PEX5L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10130:SF4">
        <property type="entry name" value="MICROBODY (PEROXISOME) BIOGENESIS PROTEIN PEROXIN 20 (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10130">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 1 RECEPTOR PEX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="335"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="339"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="363"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3303375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="373" mass="39731" checksum="539615940F01199F" modified="2024-07-24" version="1">MADNMCGPSNGAKDLLAHADRDRTIHQDRLVNAPQAGPGNAFRSQLPVDHGAAEMAFGNFQEGGAPMDATFNPGLHMTTVAPIGHHAPGAPAYGPPAVGTPMSMGYAGPSAPAARLASPLIGSDSHQEWVNQFARMQVAPGAAGPGTAMPNHLMNPAMRLQSAPFGAPMLGGAPPALLPFHGPVMNAGTQEQAQVGPLQDNAALIDDEAFNRAFDEYDDVFVDQSADWEEKQKLANTEFIKAQDQWMAEHGPRAESKRVVTPPTAEEMKVIDADLEKIAQEQDKKRSEDELARAAGEIVNSVIDDDSDKFKNSRFFELMRRIRDREVVIAGDNFVDTATGEKVEQSHSDEGDSGFNSEAIANGESNGAGSHSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GPF7</accession>
    <name>A0AAJ0GPF7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-binding-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_560939</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719497.1">
        <property type="nucleotide sequence ID" value="XM_062870547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GPF7"/>
    <dbReference type="GeneID" id="87889376"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00385">
        <property type="entry name" value="Isoprenoid_Biosyn_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32487">
        <property type="entry name" value="3-OXO-DELTA(4,5)-STEROID 5-BETA-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32487:SF29">
        <property type="entry name" value="NAD-DEPENDENT EPIMERASE_DEHYDRATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19086">
        <property type="entry name" value="Terpene_syn_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3303717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="706" mass="78531" checksum="3E166F3E3A34883F" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GPU7</accession>
    <name>A0AAJ0GPU7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tyrosinase copper-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_557322</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3303912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719692.1">
        <property type="nucleotide sequence ID" value="XM_062870443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GPU7"/>
    <dbReference type="GeneID" id="87889272"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF126">
        <property type="entry name" value="TYROSINASE-LIKE PROTEIN TYR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042607647" description="Tyrosinase copper-binding domain-containing protein" evidence="4">
        <location>
            <begin position="19"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="5">
        <location>
            <begin position="69"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3303912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="326" mass="35954" checksum="F2CB7AD78BE5479F" modified="2024-07-24" version="1">MKLSSMLMAAGAIGQAAALPANQARQGCTSPAKRIEWRQLSAADQQSYIKAVLCLKTKPSRMGLSTPLYDDFPHLHFKLNEYIHGGPPFLPWHRYFGVVYENALRECGYEGPGTYWDWTLDTAGLRLSPVMSAETGFGGNGSPNKTETSPGDGRTLQCVDSGPFAALRPEYLAIDPKTMVNFNHCLFRNLPEVSEPAAFETMAAIFGPDGIAEVQATGNWSDYHWALEAGPHGTIHACLGGEMNPTTSPNEPLFFLHHAQVDRLWWLWQQQDPARLSEYNGEASHFGEPGSREVSLDDKLLMGGIEDDVTVRDVIDTQGGRLCYTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GPX8</accession>
    <name>A0AAJ0GPX8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">serine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Seryl-tRNA synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Seryl-tRNA(Ser) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_225241</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="1"/>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3303969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719749.1">
        <property type="nucleotide sequence ID" value="XM_062862869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GPX8"/>
    <dbReference type="GeneID" id="87881698"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000069">
        <property type="entry name" value="Seryl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="entry name" value="Serine-tRNA synthetase, tRNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="SERYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719964.1">
        <property type="nucleotide sequence ID" value="XM_062869516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQB6"/>
    <dbReference type="GeneID" id="87888345"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="472"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="506"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="543"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="569"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="650"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3304184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="695" mass="78487" checksum="A70263A8F2832C84" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GQL4</accession>
    <name>A0AAJ0GQL4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_237617</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720123.1">
        <property type="nucleotide sequence ID" value="XM_062863029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GQL4"/>
    <dbReference type="GeneID" id="87881858"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1120.10:FF:000001">
        <property type="entry name" value="Ribosomal protein L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1120.10">
        <property type="entry name" value="Ribosomal protein l15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024794">
        <property type="entry name" value="Rbsml_eL15_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000439">
        <property type="entry name" value="Ribosomal_eL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020925">
        <property type="entry name" value="Ribosomal_eL15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003269">
        <property type="entry name" value="PRK04243.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847">
        <property type="entry name" value="RIBOSOMAL PROTEIN L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00827">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01384">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01194">
        <property type="entry name" value="RIBOSOMAL_L15E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3304343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="203" mass="24145" checksum="6C27B81C5AE4BBC7" modified="2024-07-24" version="1">MGALKYLEELSKKKQSDVVRFLLRVRCWELRQLNVIHRASRPSRPDKARRLGYKAKQGYVIYRVRVRRGGRKRPVPKGATYGKPTNQGVNQLKYQRSLKATAEERVGRRCANLRVLNSYWINQDSTYKYYEVILVDPQHKAIRRDPRINWIVNPVHKHREARGLTATGKKSRGLNKGHRYNKTRAGRRKTWKRHNTLSLWRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GR49</accession>
    <name>A0AAJ0GR49_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_374924</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OXA1/ALB3/YidC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720408.1">
        <property type="nucleotide sequence ID" value="XM_062864223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GR49"/>
    <dbReference type="GeneID" id="87883052"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032979">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane from matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428:SF65">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX18, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="OXA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3304628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="342" mass="37351" checksum="3F98A46A8233229D" modified="2024-07-24" version="1" fragment="single">RQFSITPFITSAISSAETVLTTLHSVTATPWYITIPLFALTLNLFTRLPAVIYSRRVAVRRATLQLQPLERAYVVRLRSELIRDMAEEVKTNNGSSHRSSLATLDKRKRLLLKANNQETARRNKRWGVQRWKDWVPSLMVFPFWVVGIEALRRMCGGPRGLLGTFVLGPPKKQPEADGAVAPGGSSGGGVGTGGIEGQVHETLASAVSGVGADTSMATGGCLWFPDLMVADPYHVLPLALSAILVMNLVPKSQVGLRALLNLDTPPEATVATSKWRLRMHRGFLVVATSAGFLTMDLPAALHLYWVTSAALTWAQTSIVWKLMPLPKQVPPAKPKERPIVPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GRM7</accession>
    <name>A0AAJ0GRM7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_537919</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720663.1">
        <property type="nucleotide sequence ID" value="XM_062869653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GRM7"/>
    <dbReference type="GeneID" id="87888482"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19077">
        <property type="entry name" value="AKR_AKR8A1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF78">
        <property type="entry name" value="PYRIDOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="13"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3304883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="329" mass="35597" checksum="2C432CBB2C0E9F6E" modified="2024-07-24" version="1">MPSLVGKQIGSTGFGLMGLATRVPPISDEQAIGAMRAAIESGMTFWNGGDHYGTPERNSQTLLANYLRRYPEDADKIVLSVKGAFDFATMSPDGSPEGIRKSIDKILADLDGTHRIDIFECSRVDPKIPLETTLKFLEEGYVNKGIIGGIALSEVAAPTIRRAAAITKIVAVEVEVSLWNTHVLENGVAAACAELNIPIVAYSPIGQGMLGGLFKSLDDLPQGDLRRYYPRFQPENFAINLELVKQLETLAKQKGCTPAQLALGWIQSLSKKPNMPTFIPIPGATTEARVRENGVHVELMEGDLKAIDHVLAKFEVVGERYPAGIPTDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GRR6</accession>
    <name>A0AAJ0GRR6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Lysozyme-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_437284</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Hydrolysis of (1-&gt;4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.17"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720460.1">
        <property type="nucleotide sequence ID" value="XM_062865847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GRR6"/>
    <dbReference type="GeneID" id="87884676"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031640">
        <property type="term" value="P:killing of cells of another organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00737">
        <property type="entry name" value="lyz_endolysin_autolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.530.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_04110">
        <property type="entry name" value="ENDOLYSIN_T4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051018">
        <property type="entry name" value="Bacteriophage_GH24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033907">
        <property type="entry name" value="Endolysin_autolysin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034690">
        <property type="entry name" value="Endolysin_T4_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002196">
        <property type="entry name" value="Glyco_hydro_24"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF00959">
        <property type="entry name" value="Phage_lysozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-1035">Host cytoplasm</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="18"/>
        </location>
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        <location>
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            <end position="96"/>
        </location>
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        <source>
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        </source>
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        <source>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51781"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3304680.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">Uncharacterized protein</fullName>
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    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
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            <taxon>Chaetomium</taxon>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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    <dbReference type="GeneID" id="87884354"/>
    <dbReference type="Proteomes" id="UP001273166">
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3304810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ0GRY8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_576190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720620.1">
        <property type="nucleotide sequence ID" value="XM_062871019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GRY8"/>
    <dbReference type="GeneID" id="87889848"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3304840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="197" mass="22594" checksum="1143F02C0ED9E45A" modified="2024-07-24" version="1">MVSITDQQGRRAELPVTGDMATKINQVVEELFQICDTPKRARLSWMKDYFLTTQADNTTLRALTQEVVKKRFESRKKSSRKHFGEARVLTVEDIRARISEREAKEAVEAREKERRIALRGVVGFAKGVWKDYKMGPDVFNFNFDPAVIMLVMPKLPGPDPCTARIYPSPESEFRAAPFDSLCCSWLVPPRPSLEEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ0GRZ6_9PEZI</name>
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        <recommendedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_398302</name>
    </gene>
    <organism evidence="3 4">
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720819.1">
        <property type="nucleotide sequence ID" value="XM_062864943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GRZ6"/>
    <dbReference type="GeneID" id="87883772"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042459130" description="C2H2-type domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3305039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="30396" checksum="AAB3DDBE7F122249" modified="2024-07-24" version="1">MSLWEWLTHARAVHKWALPGLAPCLLCGHLCAPGPGLRRHFATQHRDKLGERFNCAACLASTVPAGEAQGTYDFEELLRHGVDKHPLGQLAADGAGGKRKRDGGMSGEHTAPAAKRTKGDGDGKHPALAARRTESDGDGDRKCPAPAARHTESDGERECPALPANRKRAAGHKVAYRKELSPVAIYNADSDPCEDVIICASTINEQQTCHFTKNLIGSSAALDSEFLGNVDPALLAPWRPASAVHHTAAMLSDLPTPEALRRPRRYRGPLPWLSRRILVTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GSB5</accession>
    <name>A0AAJ0GSB5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="7">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_191442</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="7"/>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062720996.1">
        <property type="nucleotide sequence ID" value="XM_062862445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GSB5"/>
    <dbReference type="GeneID" id="87881274"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF120">
        <property type="entry name" value="BIFUNCTIONAL 3'-5' EXONUCLEASE_ATP-DEPENDENT HELICASE WRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="104"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="337"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3305216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="775" mass="86780" checksum="97CCDE2FA7E92E9C" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GSQ7</accession>
    <name>A0AAJ0GSQ7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_493412</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721010.1">
        <property type="nucleotide sequence ID" value="XM_062866943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GSQ7"/>
    <dbReference type="GeneID" id="87885772"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3305230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="93" mass="10076" checksum="0253B956914984EA" modified="2024-07-24" version="1">MDGAKSSAPAGQTSSNRVVKVNRKTVAARYNIKVLRGLETALLKDPEANLGDLLSSSYPQQLKSFKEAVPRLHGVIRIGRYGLLFTSFVSGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GTA5</accession>
    <name>A0AAJ0GTA5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1,3-beta-glucan synthase</fullName>
            <ecNumber evidence="3">2.4.1.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">1,3-beta-D-glucan-UDP glucosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0T15DRAFT_511604</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[(1-&gt;3)-beta-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;3)-beta-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21476"/>
            <dbReference type="Rhea" id="RHEA-COMP:11146"/>
            <dbReference type="Rhea" id="RHEA-COMP:14303"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37671"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.34"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.34" evidence="3"/>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721492.1">
        <property type="nucleotide sequence ID" value="XM_062867925.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87886754"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000148">
        <property type="term" value="C:1,3-beta-D-glucan synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003843">
        <property type="term" value="F:1,3-beta-D-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006075">
        <property type="term" value="P:(1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051278">
        <property type="term" value="P:fungal-type cell wall polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026899">
        <property type="entry name" value="FKS1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056261">
        <property type="entry name" value="FKS1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003440">
        <property type="entry name" value="Glyco_trans_48_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741:SF48">
        <property type="entry name" value="1,3-BETA-GLUCAN SYNTHASE COMPONENT FKS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741">
        <property type="entry name" value="LYST-INTERACTING PROTEIN LIP5 DOPAMINE RESPONSIVE PROTEIN DRG-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14288">
        <property type="entry name" value="FKS1_dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23605">
        <property type="entry name" value="FKS1_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02364">
        <property type="entry name" value="Glucan_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01205">
        <property type="entry name" value="FKS1_dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="496"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="540"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="583"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="621"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="679"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="734"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1356"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1408"/>
            <end position="1429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1499"/>
            <end position="1519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1525"/>
            <end position="1543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1615"/>
            <end position="1636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1664"/>
            <end position="1691"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1703"/>
            <end position="1729"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1741"/>
            <end position="1760"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1800"/>
            <end position="1823"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1865"/>
            <end position="1888"/>
        </location>
    </feature>
    <feature type="domain" description="1,3-beta-glucan synthase component FKS1-like" evidence="13">
        <location>
            <begin position="350"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="159"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1904"/>
            <end position="1926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3305712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1950" mass="222896" checksum="4C8C11257729EBA4" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GTB1</accession>
    <name>A0AAJ0GTB1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyruvate decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0T15DRAFT_199727</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2-oxocarboxylate + H(+) = an aldehyde + CO2</text>
            <dbReference type="Rhea" id="RHEA:11628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="EC" id="4.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 1 Mg(2+) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.1" evidence="4"/>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721285.1">
        <property type="nucleotide sequence ID" value="XM_062862559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GTB1"/>
    <dbReference type="GeneID" id="87881388"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004737">
        <property type="term" value="F:pyruvate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000949">
        <property type="term" value="P:aromatic amino acid family catabolic process to alcohol via Ehrlich pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02005">
        <property type="entry name" value="TPP_PDC_IPDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07038">
        <property type="entry name" value="TPP_PYR_PDC_IPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000019">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000024">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012110">
        <property type="entry name" value="PDC/IPDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047214">
        <property type="entry name" value="TPP_PDC_IPDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047213">
        <property type="entry name" value="TPP_PYR_PDC_IPDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452:SF30">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE ISOZYME 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036565">
        <property type="entry name" value="Pyruvt_ip_decrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="15">
        <location>
            <begin position="16"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="13">
        <location>
            <begin position="212"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="14">
        <location>
            <begin position="411"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="481"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR036565-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3305505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="574" mass="63555" checksum="20BABBD9563F843C" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GTD2</accession>
    <name>A0AAJ0GTD2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cleavage and polyadenylation specificity factor subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cleavage and polyadenylation specificity factor 100 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_209432</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721551.1">
        <property type="nucleotide sequence ID" value="XM_062862653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GTD2"/>
    <dbReference type="GeneID" id="87881482"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16293">
        <property type="entry name" value="CPSF2-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027075">
        <property type="entry name" value="CPSF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025069">
        <property type="entry name" value="Cpsf2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035639">
        <property type="entry name" value="CPSF2_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922:SF1">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13299">
        <property type="entry name" value="CPSF100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Beta-Casp" evidence="6">
        <location>
            <begin position="286"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="514"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="616"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="835"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="523"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="682"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="838"/>
            <end position="856"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3305771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="990" mass="107312" checksum="0619215E33C0905E" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GU24</accession>
    <name>A0AAJ0GU24_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial inner membrane protein 1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_503125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3306143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721923.1">
        <property type="nucleotide sequence ID" value="XM_062867460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GU24"/>
    <dbReference type="GeneID" id="87886289"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021836">
        <property type="entry name" value="DUF3429"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15887">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15887:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11911">
        <property type="entry name" value="DUF3429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="225"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3306143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="448" mass="49739" checksum="09F6EBC93281670D" modified="2024-07-24" version="1">MLSTAVRRAQPLSTRARMFAINGRAQRSAPISSLLGLSPSPRPSPAPATAGTYSRTTFSTKPPLQPKGIDKDFEKEVAQKKLEPRPEEVTTQSSVRHVMEQSQAPPEQTPDVMVDLKNDLNTVKETFALGSVPRENYALGLAGTLPYLATSLSTVFLSWNLNIDYPTKSLHLNSLLFDHDAATYWLQVLEPIQVGYGAVIVSFLGAIHWGLELAEKQPARDRTRFRYAIGVLAPAVAWPTIFMPTVWALTTQFGAFGALYFADARATAKGWAPPWYQTYRFVLTAVVGVALMVSLLGRAKVGEGHPRLSKADIAERLKGNIKTEDYRKWAKEEEKEKERVREEKKKEEERRKEAEKKAKEEEQKNKEQKGDPEKSEHKSGSEDKDSSKSDDKQKGGEQQDGKQKEGEKKDGGKKDGEKKDGEQKDGAQKDGAQKDGAQKDGAQKDGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GUE7</accession>
    <name>A0AAJ0GUE7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_526803</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722049.1">
        <property type="nucleotide sequence ID" value="XM_062868928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GUE7"/>
    <dbReference type="GeneID" id="87887757"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042506913" description="Secreted protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3306269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="88" mass="9702" checksum="2B91806D29C23F0C" modified="2024-07-24" version="1">MLLCILLASDSCFPSLASASCTLVSLKLPRYVTAWALLCHHSVACMCALNLLFRPCFLFLFSVFQCLYPVSCSLCPCLILVGYPETFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GUF7</accession>
    <name>A0AAJ0GUF7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">3-ketoacyl-CoA thiolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0T15DRAFT_136359</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21564"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.3.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722059.1">
        <property type="nucleotide sequence ID" value="XM_062861816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GUF7"/>
    <dbReference type="GeneID" id="87880645"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050215">
        <property type="entry name" value="Thiolase-like_sf_Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853:SF10">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="10">
        <location>
            <begin position="30"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="11">
        <location>
            <begin position="293"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="8">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="370"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3306279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="415" mass="44031" checksum="7A0313ECADF1D9D5" modified="2024-07-24" version="1">MAVERLGSILKHLSPGSALSQITSKNADDIVITLAVRTPLTKAKKGGFKDTSLEYMVYALLKEVRERSKLDPALVEDICLGNVSDSKAAYKLRAAMLAAGFPNTTSGSSLNRFCSSGLKAVADIAHAISSGSIEIGVAMGAEQMTIGGDALDKPFDEEVTKHSQEAVDSMQPMGWTSENVSRDFGITREEMDKYAAESFQRAERAQKAGLFDDEIVPIQTRVKDANGEWKSVTLTRDDGIRPGTTAEGLSKIRVAFPQWGPTTTGGNASQVTDGAAAILLMKRSTAIKLGQPILAKYVGSTVAGLAPRIMGIGPTVAIPKLLAQHNLSLADVDVIEINEAFASMAVYCRDKLGLDWAKMNPRGGAIALGHPLGATGARQIVTGLSECRRTGKKILLTSMCIGTGMGMAGLFVNEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GUX9</accession>
    <name>A0AAJ0GUX9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein uL29m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">54S ribosomal protein L4, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_527839</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722421.1">
        <property type="nucleotide sequence ID" value="XM_062868996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GUX9"/>
    <dbReference type="GeneID" id="87887825"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038340">
        <property type="entry name" value="MRP-L47_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010729">
        <property type="entry name" value="Ribosomal_uL29_mit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21183:SF18">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL29M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21183">
        <property type="entry name" value="RIBOSOMAL PROTEIN L47, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06984">
        <property type="entry name" value="MRP-L47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="231"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="232"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3306641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="282" mass="31335" checksum="15CB07BC71EB45D2" modified="2024-07-24" version="1">MASAAIRPSLGAFGRISSAAAATTAPRSLVSTTQTASLSTTTSLLKRHKYPGARDNKDYSKHRGESAIRRTGTRWRLSMSDEPLPKPVPREQLPPIETDPDHGLWEFFANRKTVANAPEEDAKYGRSWSVEELRHKSWDDLHRLWWVCVKERNRIATANWERNKSKLGFGEAEALARDREVRATMRAIKHALTERFYTWEDAVKLAENDPEVNLTGDGPAFTPRDYLEEGEATAAEGEQQQQVAEAAEAAEETAVKAQPAPPVTPDPAMIPASQPQAEAPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GVK1</accession>
    <name>A0AAJ0GVK1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_484174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TTI2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722716.1">
        <property type="nucleotide sequence ID" value="XM_062866211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GVK1"/>
    <dbReference type="GeneID" id="87885040"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110078">
        <property type="term" value="C:TTT Hsp90 cochaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018870">
        <property type="entry name" value="Tti2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32226">
        <property type="entry name" value="TELO2-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32226:SF2">
        <property type="entry name" value="TELO2-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10521">
        <property type="entry name" value="Tti2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3306936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="573" mass="62623" checksum="7C376DE1F09AF135" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GVZ8</accession>
    <name>A0AAJ0GVZ8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase</fullName>
            <ecNumber evidence="4">1.1.1.302</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0T15DRAFT_484250</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes an early step in riboflavin biosynthesis, the NADPH-dependent reduction of the ribose side chain of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NAD(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27274"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58890"/>
            <dbReference type="ChEBI" id="CHEBI:59545"/>
            <dbReference type="EC" id="1.1.1.302"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NADP(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27278"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58890"/>
            <dbReference type="ChEBI" id="CHEBI:59545"/>
            <dbReference type="EC" id="1.1.1.302"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; riboflavin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HTP reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.302" evidence="4"/>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722795.1">
        <property type="nucleotide sequence ID" value="XM_062866220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GVZ8"/>
    <dbReference type="GeneID" id="87885049"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="entry name" value="Dihydrofolate Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050765">
        <property type="entry name" value="Riboflavin_Biosynth_HTPR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38011:SF7">
        <property type="entry name" value="2,5-DIAMINO-6-RIBOSYLAMINO-4(3H)-PYRIMIDINONE 5'-PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38011">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_8G06820)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="Dihydrofolate reductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="domain" description="Bacterial bifunctional deaminase-reductase C-terminal" evidence="13">
        <location>
            <begin position="45"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3307015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="282" mass="30012" checksum="6F2C7B13F8DF4528" modified="2024-07-24" version="1">MAAAGWEPREQETLSFPSEARALITPYLPPSTPTTQTLQEPRKYPHVTLTYAQSLDTSLALAPGVRTALSGPQSKAMTHFLRAHHDAILVGAGTAVADDPGLNSRLLDPRRQPRPIVLDPRGRWSVHEGSKAVRVARAGKGLGPWVLVAGDHGDGTGVVVDEARRRVVEEVGGKYIPLEARAEGGRFEWVDVLGLLKREGLESVMIEGGGEVINSLLASPGNGLVDSVIVTIAPTWLGQGGVVVSPARTVGEHGQPAQPVRLTGVKWCPLGEDVVLCGRILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GWU8</accession>
    <name>A0AAJ0GWU8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Beta-glucuronidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_530686</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723396.1">
        <property type="nucleotide sequence ID" value="XM_062869187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GWU8"/>
    <dbReference type="GeneID" id="87888016"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052974">
        <property type="entry name" value="GH79_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031728">
        <property type="entry name" value="GlcAase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183:SF2">
        <property type="entry name" value="BETA-GLUCURONIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16862">
        <property type="entry name" value="Glyco_hydro_79C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042577602" description="Beta-glucuronidase C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-glucuronidase C-terminal" evidence="2">
        <location>
            <begin position="448"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3307616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="542" mass="57660" checksum="AC8535D74BF2A705" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GXH9</accession>
    <name>A0AAJ0GXH9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_181803</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723320.1">
        <property type="nucleotide sequence ID" value="XM_062862320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GXH9"/>
    <dbReference type="GeneID" id="87881149"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052250">
        <property type="entry name" value="PDI_TMX3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46426">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46426:SF1">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042543022" evidence="6">
        <location>
            <begin position="19"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="7">
        <location>
            <begin position="8"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="7">
        <location>
            <begin position="248"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="163"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="180"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3307540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="746" mass="83976" checksum="F0C2A092454BF78E" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GXI4</accession>
    <name>A0AAJ0GXI4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_549913</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723782.1">
        <property type="nucleotide sequence ID" value="XM_062870235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GXI4"/>
    <dbReference type="GeneID" id="87889064"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF11">
        <property type="entry name" value="O-METHYLTRANSFERASE (AFU_ORTHOLOGUE AFUA_2G17820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="227"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3308002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="397" mass="45112" checksum="FBC698CDDDE00821" modified="2024-07-24" version="1">MEDTSAALRAAEELVEALKRHPRASKAEHLALLERVDKVRSLLETPYDVMERQQEVMCAAGVMYTLIMTGAIKKVPNEGTITARELAVEMNMDVSAIQRLMRAAIVSGFFAETAPDTYAHNALSQAYQLDAQGPFFVLCMGFNKMCMTLPEYFKTHQPEEIYDLKKSPFCFSIGKEGKTYYEAIDEDAEQRDIWNKCLQIIEKNMPISGMFPWESLKEQVEKEPERPFFVDVAGGRGQACLKLQEEIPGTFGGKLILQDLPIVINSLKPEEIPNIEPMAYDIFTPQPVKNAHVYFMRRLLHDFYPSVCIDILRNTVSAMGPESRLIVCDMLVPEKVEPGHLKELYWLDLNLMSISGKEKTLDEFREMFDAVGLELVKVWPSSIGATVQLETRLKRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GXP9</accession>
    <name>A0AAJ0GXP9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_549614</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3307785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723565.1">
        <property type="nucleotide sequence ID" value="XM_062870222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GXP9"/>
    <dbReference type="GeneID" id="87889051"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="29"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="99"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3307785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="483" mass="53481" checksum="7B4629963A557AC9" modified="2024-07-24" version="1">MLRISSVRGGIKDTAPSAAVIADNIIRVYGSESRSRSEASSHGRKRVRGPVRSSTPTPTRSPSAGRSRPRQHREPSPAAQTVDEKVQRFLRSMSPPSPTEELKKENRSLHQRVAALQLTERDLLNDNQDLARRLASTQKRQETRRRQWKEELLNREKVFEARIKDLESRLARQEEELVRVTLGRTRETAGLSDHAIASWFATKASAWHGWAEDFAHQDPDRVRSGLHPLQLQLPEGLLSPAGNDGAQTAQVLLQGITLELESPGVSRIDSPIGFRMDLAMWDLDVSPPGDVRSPRPAVMANGGRHGPHAMRSLPRLVTSMESAGSSPLGQNLPTRRATEGLHRMFLNAPGGAENVNAWRSSVLKAFCEGGMSTSVDSILLTEDAARPLSRGQAPVRGLKDAFLRSPARFLLRDQDAAGIEKLERRLVQEMDSALRFSCQLWCRREPISVRGLDELVDTAFSAASDSMELCQAQQAPPPPRYAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GXT3</accession>
    <name>A0AAJ0GXT3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_490709</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723889.1">
        <property type="nucleotide sequence ID" value="XM_062866703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GXT3"/>
    <dbReference type="GeneID" id="87885532"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3308109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="55" mass="6227" checksum="AC1E18B3687F7061" modified="2024-07-24" version="1">MAATAFFATSSLVSYGRSGYNKGNSDDDEEQNKLRDYGRSGYNKDDKDDEEDKQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GY79</accession>
    <name>A0AAJ0GY79_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA replication licensing factor MCM2</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">DNA replication licensing factor mcm2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Minichromosome maintenance protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">B0T15DRAFT_428486</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3307930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723710.1">
        <property type="nucleotide sequence ID" value="XM_062865689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GY79"/>
    <dbReference type="GeneID" id="87884518"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17753">
        <property type="entry name" value="MCM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000002">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000138">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008045">
        <property type="entry name" value="MCM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF44">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12619">
        <property type="entry name" value="MCM2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01658">
        <property type="entry name" value="MCMPROTEIN2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="20">
        <location>
            <begin position="491"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="697"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="868"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="736"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00074927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00078186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAK3307930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="888" mass="98779" checksum="7D000936ED4D8337" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GYD8</accession>
    <name>A0AAJ0GYD8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acyl-CoA dehydrogenase/oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_428612</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723800.1">
        <property type="nucleotide sequence ID" value="XM_062865691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GYD8"/>
    <dbReference type="GeneID" id="87884520"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052904">
        <property type="entry name" value="Acyl-CoA_dehydrogenase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041504">
        <property type="entry name" value="AidB_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42707:SF2">
        <property type="entry name" value="ACD11 DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42707">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18158">
        <property type="entry name" value="AidB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="2 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Adaptive response protein AidB N-terminal" evidence="7">
        <location>
            <begin position="19"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="6">
        <location>
            <begin position="190"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="5">
        <location>
            <begin position="325"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF18158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3308020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="663" mass="72691" checksum="70B67D69C95DE140" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GYZ9</accession>
    <name>A0AAJ0GYZ9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent DNA ligase family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_483355</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_062866157.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032807">
        <property type="term" value="C:DNA ligase IV complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
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        <property type="entry name" value="LIG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45997:SF2">
        <property type="entry name" value="ATP DEPENDENT DNA LIGASE DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G02430)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45997">
        <property type="entry name" value="DNA LIGASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="7">
        <location>
            <begin position="380"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="655"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="898"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="656"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="684"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="746"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="801"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="918"/>
            <end position="946"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3308766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1031" mass="115171" checksum="18978C16CD348918" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GZM4</accession>
    <name>A0AAJ0GZM4_9PEZI</name>
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        <recommendedName>
            <fullName evidence="2">Pleckstrin homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_129854</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_062861739.1"/>
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    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:phospholipid binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032065">
        <property type="term" value="P:maintenance of protein location in cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053005">
        <property type="entry name" value="Nuclear_Pos-Cytoskel_Interact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024774">
        <property type="entry name" value="PH_dom-Mcp5-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28190:SF2">
        <property type="entry name" value="MIGRATION PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G07730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28190">
        <property type="entry name" value="NUCLEAR MIGRATION PROTEIN NUM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12814">
        <property type="entry name" value="Mcp5_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="950"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="700"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="795"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1125"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="1355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
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            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="414"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="469"/>
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    </feature>
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        <location>
            <begin position="509"/>
            <end position="530"/>
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    </feature>
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        <location>
            <begin position="653"/>
            <end position="663"/>
        </location>
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        <location>
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        <location>
            <begin position="721"/>
            <end position="734"/>
        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="851"/>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
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            <end position="1322"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1345"/>
            <end position="1355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3309103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1355" mass="148774" checksum="E23AF41963FF39EB" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GZS5</accession>
    <name>A0AAJ0GZS5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BAR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_526320</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3309144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724924.1">
        <property type="nucleotide sequence ID" value="XM_062868902.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87887731"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990528">
        <property type="term" value="C:Rvs161p-Rvs167p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07599">
        <property type="entry name" value="BAR_Rvs167p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000048">
        <property type="entry name" value="BAR adaptor protein RVS167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000189">
        <property type="entry name" value="BAR adaptor protein RVS167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF1">
        <property type="entry name" value="REDUCED VIABILITY UPON STARVATION PROTEIN 167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="BAR" evidence="8">
        <location>
            <begin position="17"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="403"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="303"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="331"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="354"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3309144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="463" mass="51746" checksum="B30BD1360457043D" modified="2024-07-24" version="1">MSLRGFQKGIVRAPQQIKAKFNIGEHTKDAVYIDSERRFQELETETKHLHDESKKYFDAINGMLTHQIEFSKAMTEIYKPISGRMSDPETLVVQGNPEGIRACEEYEAVVKDLQETLAPELEMIESRVIRPANELLDVIKVIRKTAVKREHKKLDYDRHRATLKKLQEKKDKTAKDEKAMWKAENDVEQSTQEFNYFNDLLKEELPRLFALEREFIQPLFQSFYYMQLNIFYTLHERMQQVDIGYFDLTLDVEEAFHKKRGDIQERAEALSIVRFKTSGQKRPPKYGGPRPGTAIEGRQNAGLLTAGPASSSSSTSTPGGAESVTAAAATPSKSAVVSSLRPTWQPRQTDVVENPPPPYSPAPVSPALGSPGTASLAVAAAAKSKPKPPPPPKPKPSRLSATPKVETVTALYDYAAQAEGDLSFRAGDVIEVVTRTANENEWWTGRLNGKSGQFPGNYVKLNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GZZ5</accession>
    <name>A0AAJ0GZZ5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_376043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3309283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725063.1">
        <property type="nucleotide sequence ID" value="XM_062864231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GZZ5"/>
    <dbReference type="GeneID" id="87883060"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3309283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="206" mass="23275" checksum="302249F10E13ED47" modified="2024-07-24" version="1" fragment="single">GYTQDEWPLEDECRTVALLEKIKRAMADAGAHPDRPIGPMRKPKTAGDVVANLRSFSDEARRSPPSTDSTPPPDDSIPLPPFPPLPACYGWTAVPRDETPYLNPPVSDLVDWEVDWHWAIVYELVPGAPQDIQVGQAHLDFFYAVGFAMEAYKPDNWRGGRLVDFNDVCSPFTIGWTRTAVVPRDAQTWFWTLDFRNDRGIRHTIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H021</accession>
    <name>A0AAJ0H021_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_126813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3309015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724795.1">
        <property type="nucleotide sequence ID" value="XM_062861696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H021"/>
    <dbReference type="GeneID" id="87880525"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3309015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="142" mass="15977" checksum="AD80FF64190BD5B2" modified="2024-07-24" version="1">MDTEFSFWFNGLGFEDGGELTWGLEGEAGKRRAYLGVYDVQVVLCGCGIYTTYLGRQLIVRCCVFLSTSCNIIILVPSKPEMSLNWVRFALGFPLLVCHTMPCHHRKTDKLTYAPAFARVSLPIILFLSFLTYTSGIMSLRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H046</accession>
    <name>A0AAJ0H046_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Putative transcription factor kapC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_128129</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Putative transcription factor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the bZIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3309060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724840.1">
        <property type="nucleotide sequence ID" value="XM_062861718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H046"/>
    <dbReference type="GeneID" id="87880547"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF11">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="10">
        <location>
            <begin position="92"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3309060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="196" mass="21821" checksum="BD2174A26B98AADE" modified="2024-07-24" version="1">MEDLGNFVDFPSPPHSLYYAYGDSEPHASEFQSPSDSVYDTTSAAESGISSRYPSPGHEEGDSSESTQQQKPAAKRKRENRYKNAPPAVLSRRRAQNRASQRAYRERKDQRIKDLEQMLNDAKQRNDVLSQAYAALHAEYAALKASQASEPSPSYSQRYDLQTYSGGGPSMGLPAGADSLDMDMFVYHDMSTTYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H0K6</accession>
    <name>A0AAJ0H0K6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_545341</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725332.1">
        <property type="nucleotide sequence ID" value="XM_062870131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H0K6"/>
    <dbReference type="GeneID" id="87888960"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053247">
        <property type="entry name" value="GPCR_GPR1/git3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42058:SF1">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 2 PROFILE 2 DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="7tm_2"/>
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    </dbReference>
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        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="221"/>
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            <end position="289"/>
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        <source>
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        </source>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ0H0Q6_9PEZI</name>
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        <recommendedName>
            <fullName evidence="1">DUF7580 domain-containing protein</fullName>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
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    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Bonometti L."/>
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                <person name="Cros-Aarteil S."/>
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
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                <person name="Chen C."/>
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                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
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                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <location>
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            <end position="585"/>
        </location>
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    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24476"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3309627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="593" mass="67221" checksum="4547D6BA6E0ADFA4" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H0W6</accession>
    <name>A0AAJ0H0W6_9PEZI</name>
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        <recommendedName>
            <fullName evidence="10">WD repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_515414</name>
    </gene>
    <organism evidence="8 9">
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        <lineage>
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            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
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                <person name="Martin F."/>
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                <person name="Lalanne C."/>
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                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
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                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
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                <person name="Westerberg I."/>
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                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062868191.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87887020"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0061700">
        <property type="term" value="C:GATOR2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:positive regulation of macroautophagy"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037590">
        <property type="entry name" value="WDR24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46200">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46200:SF1">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0853">WD repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="164"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="260"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="446"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1305"/>
            <end position="1352"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="449"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="476"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="488"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1316"/>
            <end position="1328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3309415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1352" mass="146337" checksum="7466C1A68B5E03B2" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H102</accession>
    <name>A0AAJ0H102_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_570538</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725626.1">
        <property type="nucleotide sequence ID" value="XM_062870839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H102"/>
    <dbReference type="GeneID" id="87889668"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF210">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ASQL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3309846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="507" mass="56588" checksum="6FE5A75CE2094248" modified="2024-07-24" version="1">MAGLIPLACVACVLLLVYWVSGAAYNLFLHPLRRYPGPRHWAATRLFLTASTLRGRAVHEINAMHRRYGHVVRIAPDQLSYTDERAWRDICGVTRAAPLGMRKDDRLNDLVGGHATNPDPSKHKADMQHTRMRRALAPAFTMASLRQQVPLVMRHVDELVALLMTAAREGRPVDMGRLYTFTLYDIFSDLFLGESFHLLSDAALHQWASSMVGFAKATTALAALSHFPLARLVIRLLLKFAGAKSRDAFMNPCFDRFERRAAQGSKGGTTGGRCDVVHFVLESRNSKQQVTEKELRDFSPFLMIGGGETMASLMPCLTYLLLKHPDVYQRLTSEIRGADFASDATADLTVEGILRLPYLGACIDEALRMYPPVPHGNERVVPAGGASVCGDRLPEGTIVVVSQLSTYRQKRNWFRPDSFLPEMWLPGAATEFAQDCHASFKPFLVGPQGCVGQELANLTMRLILSKLLLNFDLELEPESDMAWQADLPVYNVWIKPPLRVQLTRCRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H2C1</accession>
    <name>A0AAJ0H2C1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cysteine synthase 2</fullName>
            <ecNumber evidence="4">2.5.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Cysteine synthase-like protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">O-acetylserine (thiol)-lyase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">O-acetylserine sulfhydrylase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B0T15DRAFT_39751</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate</text>
            <dbReference type="Rhea" id="RHEA:14829"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.5.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="4"/>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726271.1">
        <property type="nucleotide sequence ID" value="XM_062864905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H2C1"/>
    <dbReference type="GeneID" id="87883734"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000096">
        <property type="entry name" value="Related to cysteine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="17">
        <location>
            <begin position="81"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00078263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00078545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00079149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK3310491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="439" mass="47353" checksum="D76A8FEF9CE54ED6" modified="2024-07-24" version="1">MSLSDHPRVYGTAALAVAFIAGIFATLGFKDLYPELEARYQGRRKRPRRGSMLFGPVKLEDREESFMSSSARGNGIVDGIEGTIGNTPLIKIRSLSEATGCTILAKAEFLNGAGGSPKDRVALNMIQVAEEQGLLSPGRGDTIYEGTVGSTGISLAVLARARGYKAHICMPDDMAIEKSDLLHHLGATVERVAVAPITDPGHFVNLARSRAKEHTAASDTPSRGFFADQFESMANYTAHMKTTGPEIYAQTEGRLDAFVAGAGTGGTIAGVTKYLKEERKLTALKVVLADPQGSGLYNKIRHGVMYSPTEREGTRRRQQVDTMVEGIGINRITENFEVGRGLIDDAVKVTDEQACRMARWLVEHDGIFVGSSSAVNCVAAVVTALKMPRGSQVVTILCDSGTRHLSKFWKHIAAMGLEDETQEQGEDLLAALGLQNLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H2L0</accession>
    <name>A0AAJ0H2L0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Telomere length regulation protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_45913</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TEL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726473.1">
        <property type="nucleotide sequence ID" value="XM_062865968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H2L0"/>
    <dbReference type="GeneID" id="87884797"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051083">
        <property type="term" value="P:'de novo' cotranslational protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.720:FF:000004">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.720">
        <property type="entry name" value="Telomere length regulation protein 2, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038528">
        <property type="entry name" value="TEL2_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051970">
        <property type="entry name" value="TEL2_Regulation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019337">
        <property type="entry name" value="Telomere_length_regulation_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15830">
        <property type="entry name" value="TELOMERE LENGTH REGULATION PROTEIN TEL2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15830:SF10">
        <property type="entry name" value="TELOMERE LENGTH REGULATION PROTEIN TEL2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10193">
        <property type="entry name" value="Telomere_reg-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Telomere length regulation protein conserved" evidence="3">
        <location>
            <begin position="605"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="531"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="808"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="540"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="565"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="826"/>
            <end position="838"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3310693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1018" mass="111725" checksum="25DEF78AD8F9564F" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H2Q7</accession>
    <name>A0AAJ0H2Q7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_507387</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726531.1">
        <property type="nucleotide sequence ID" value="XM_062867643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H2Q7"/>
    <dbReference type="GeneID" id="87886472"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12400">
        <property type="entry name" value="RRM_Nop6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000376">
        <property type="entry name" value="Putative RNA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034228">
        <property type="entry name" value="Nop6_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF51">
        <property type="entry name" value="NUCLEOLAR PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="180"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="262"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="90"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="146"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="270"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="318"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3310751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="329" mass="36894" checksum="86DE7FF3C7A1C7A6" modified="2024-07-24" version="1">MGKSSRKRERTSDEDVADTNDAKPIVKKSKLDHTDQTEVKKGSKTKEAKSGPAAVEQSSKSKKEKKEKKEKKEKKEKKEKKEKKHEVTEAETAAESVTEPTTVAPADSEPKEENGATNGVPSSTDKQSTKEEKKKKKKDKKKKAKPSAEAHPDAGPEKEEASFEETAAAADGEKEKQTRFICFVGNLPFTATVDAVTKHFSSLQPTSVRLLTQRDDPSKSRGIAFVEFGRYDHMKTCLEKFHHTEFDDGISPPRRINVELTAGGGGKTAKRVDKIKQKNAKLNEERAQRMKKEEEAKQEKERVAPKTQEQRDEDAIHPSRRARVPYGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H388</accession>
    <name>A0AAJ0H388_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA-directed RNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0T15DRAFT_386669</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RdRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="2"/>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726519.1">
        <property type="nucleotide sequence ID" value="XM_062864336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87883165"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058752">
        <property type="entry name" value="RDRP_C_head"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF55">
        <property type="entry name" value="RNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26253">
        <property type="entry name" value="RdRP_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RDRP core" evidence="10">
        <location>
            <begin position="505"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="domain" description="RDRP C-terminal head" evidence="11">
        <location>
            <begin position="1103"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="25"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1327"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1456"/>
            <end position="1491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1370"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1461"/>
            <end position="1475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF26253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3310739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1502" mass="168517" checksum="24E8D52AFB41FC74" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H3W8</accession>
    <name>A0AAJ0H3W8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear protein localization protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_520917</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the import of nuclear-targeted proteins into the nucleus and the export of poly(A) RNA out of the nucleus. Has a role in the endoplasmic reticulum-associated degradation (ERAD) pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NPL4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727042.1">
        <property type="nucleotide sequence ID" value="XM_062868533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H3W8"/>
    <dbReference type="GeneID" id="87887362"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08061">
        <property type="entry name" value="MPN_NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17055">
        <property type="entry name" value="Ubl_AtNPL4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Westerberg I."/>
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                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
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                <person name="Haridas S."/>
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                <person name="Riley R."/>
                <person name="LaButti K."/>
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                <person name="Chen C."/>
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                <person name="Ohm R.A."/>
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                <person name="Ament-Velasquez S.L."/>
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                <person name="Grigoriev I.V."/>
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
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        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
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                <person name="Lipzen A."/>
                <person name="Chen C."/>
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                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
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                <person name="Natvig D."/>
                <person name="Lalanne C."/>
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                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
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                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the annexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727386.1">
        <property type="nucleotide sequence ID" value="XM_062867697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H4F7"/>
    <dbReference type="GeneID" id="87886526"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:calcium-dependent phospholipid binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="4"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Annexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502:SF102">
        <property type="entry name" value="ANNEXIN B11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00191">
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="ANNEXIN"/>
    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0041">Annexin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="18"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="77"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
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            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="143"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3311606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="486" mass="53128" checksum="F37B168139FE64F6" modified="2024-07-24" version="1">MSSQQPYYGQQPPQDYGGPPPPGAPPGNYPPQGAPIPSAPYQYPPGLAPGQAPGQAPYQQPVQPPYGYQSAPPPQPGAQTGQYQYPQAPQGAPYGQQLPPNVAYAPYGQQPPPPPPPGQYAAQPPYGQPSAGYGQAPPPHGYPPQGQQQWPGFGAPAVQAAPASPGYDIAQKAWAQPVNTSSDAEALRRAMKGMGCDEKALIRVLTSPQYANPWAMLQLVQDYNTRFLRNLEEDIKGETRGLLETALLALMRGPLGHDAYVLDKALNRLGTDEEALMDVLLNRSNADLRAITAEYKRVTQRDLLVDIKDDVDEALFRLCSMLLAANRAEDAAPVLAHEIDAKVTELQRATEGMIGANAVAVVQIFASSNAAQINAMAEAYQRKYHRPLADVIEKEFRGGMEDALLRMLTSAQNRAEYDAFRLREALTKRKDKLVINRVVSLYWDLPRLEAAKQAYQRKFNANFAKEVKALLKGDLEDVILAMIREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H4J8</accession>
    <name>A0AAJ0H4J8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine hydrolase FSH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_386887</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727426.1">
        <property type="nucleotide sequence ID" value="XM_062864349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H4J8"/>
    <dbReference type="GeneID" id="87883178"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF6">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="3">
        <location>
            <begin position="38"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3311646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="314" mass="33833" checksum="BB78A1458FC1E223" modified="2024-07-24" version="1">MGDAIATPPSEPSAHPPPQQQQQQRPPKKKNAAAPAKKEVRILMLHGYTQSGPLFRAKTRALEKLLAKALAPAGLVPALLYPTAPTRLSARDIPGFDAFRRSSGDDQQGEEGGTVEEEEMDAWAWFRHDRAAGRYKLVEEGMVSLAKGISEWKEEGVAEGEEGGGVVDGVLGFSQGGCVAGMLAAALEEGRTTTTTTTTGEEAKEHEGWVRAVREANGGRPLKFAVVYSGFWATPADLGWLYEPKIRTPTLHVLGSLDTVVEESRSQGLVERCEDPLVLTHPGGHYVPVNKEWVMPVAGFIKKCVESAADATKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H4K2</accession>
    <name>A0AAJ0H4K2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_522337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727502.1">
        <property type="nucleotide sequence ID" value="XM_062868619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H4K2"/>
    <dbReference type="GeneID" id="87887448"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="63"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3311722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="218" mass="24350" checksum="B67D90A7B3B72BA8" modified="2024-07-24" version="1">MWVHGVAGKGAEGRVAVNRSLGRVLSKGCIADSSGEAMSTKVRPHLEAILASPLDEVATYRPLLQEFFDKLNEISKLPLWVSHYDLNDVNVLIDESCEVTGLVDWELSTPKPFGVGLGRIQTLAGEYTGGEFWRPDEFEVAERAFWKELFAGMSQKTREMLEKNIGLVQDAVILGTLLDTFFWEDGKVGCGEVSMKTLPKFLTYRIPQARGHELPYKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0H4L9</accession>
    <name>A0AAJ0H4L9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_521481</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727220.1">
        <property type="nucleotide sequence ID" value="XM_062868564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0H4L9"/>
    <dbReference type="GeneID" id="87887393"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034647">
        <property type="term" value="F:histone H3K4me/H3K4me2/H3K4me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694:SF33">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="4">
        <location>
            <begin position="336"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="76"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="163"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="573"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="610"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="764"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="576"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="645"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3311440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1194" mass="132762" checksum="C36B9C0766C255B5" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LXU4</accession>
    <name>A0AAJ0LXU4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0T15DRAFT_563064</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717434.1">
        <property type="nucleotide sequence ID" value="XM_062870603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LXU4"/>
    <dbReference type="GeneID" id="87889432"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17966">
        <property type="entry name" value="DEADc_DDX5_DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000079">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="13">
        <location>
            <begin position="135"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="166"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="373"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="9">
        <location>
            <begin position="135"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3301654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="561" mass="60375" checksum="E7BFFA915402D653" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LXV5</accession>
    <name>A0AAJ0LXV5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Glycoside hydrolase family 17 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_321056</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717464.1">
        <property type="nucleotide sequence ID" value="XM_062864054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LXV5"/>
    <dbReference type="GeneID" id="87882883"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000490">
        <property type="entry name" value="Glyco_hydro_17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF16">
        <property type="entry name" value="GPI-ANCHORED CELL WALL BETA-1,3-ENDOGLUCANASE EGLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00332">
        <property type="entry name" value="Glyco_hydro_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00587">
        <property type="entry name" value="GLYCOSYL_HYDROL_F17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="319"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="320"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3301684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="417" mass="43189" checksum="A9D633C0D3BB1DDE" modified="2024-07-24" version="1">MRPTTAFLAGALASGVSAENYLGFNSGATLADRSAKFKSDFLAEFKTAQGLKNAPGKFNAVRLYTNIQAYSETDPIQAFEAAIETNTKLLLGIWTSGTDNIDKELAALKKAIEKYGSKFTDLVIGMSIGSEDLYRVSATGIANKSGVGAGPDVLVNFINQYKKAVANTALAKVPIGHVDTWDAWTNGTNKAVVDAVDWVGVDEYPYYENGKGNDIKNSGKLFDRAYDAVAGAVGGKPVWVTETGWPSTGPNWDQAVPSVENAKYYWDEVGCRKLFNKVPTFWYNLRDSNPDNEMKFAITKDLSTTPLFDLTCPTKFDTPTATAKTSSAAATGSSSTAVSAPGSSSTGSAGSTNSTAGSGSGSGSSGTDNGSGSGTGTGEQAAGPSSSVVTGGAFVGKSLSAAAVVSLALVAGVFALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LXX0</accession>
    <name>A0AAJ0LXX0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_514979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717509.1">
        <property type="nucleotide sequence ID" value="XM_062868151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LXX0"/>
    <dbReference type="GeneID" id="87886980"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="248"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3301729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="313" mass="33382" checksum="C4B6A9DE3F25175D" modified="2024-07-24" version="1">MGSQDSSRYGSGRSSPRAIPSVRLDPSAGPGLTWAAGYGRNNSSTRITSSTHSAGDDGLLFPLDPEPWRNPFSTRSPPPAYPGRGASSTAAASGSYSGAPSGNPSPAGSFNHSRSPTVAGSTCSSSTSSALGSYSSLLNPYRPSTRRLRERDRTTTTSSRRYGSPSPFRLPCPLPETPRARSPTTSTSTDLSSRYNPNSSRHPRPRNRDRLRGYGTFDSPQGSDISRRSSSRLSRASTAVDDEPPSPSIYAASPAARSYADSTAPGYRDPNPGYYSPIVESPAFGSSPTRWARAPGRRDMDSRRDRSSRGYTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LY03</accession>
    <name>A0AAJ0LY03_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thioesterase-like superfamily-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_405190</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717553.1">
        <property type="nucleotide sequence ID" value="XM_062865285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LY03"/>
    <dbReference type="GeneID" id="87884114"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03444">
        <property type="entry name" value="Thioesterase_II_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="entry name" value="Acyl-CoA thioesterase, double hotdog domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049450">
        <property type="entry name" value="ACOT8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049449">
        <property type="entry name" value="TesB_ACOT8-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066:SF64">
        <property type="entry name" value="ACYL-COA THIOESTERASE (AFU_ORTHOLOGUE AFUA_1G12060)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13622">
        <property type="entry name" value="4HBT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20789">
        <property type="entry name" value="4HBT_3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioesterase-like N-terminal HotDog" evidence="4">
        <location>
            <begin position="55"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA thioesterase-like C-terminal" evidence="5">
        <location>
            <begin position="269"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="122"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="169"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="122"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3301773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="371" mass="40473" checksum="F6B11F56EBCE9EB9" modified="2024-07-24" version="1">MPSPHNDPPLPLQEVLDVVNLTPEGEARRFMGRRAAHLPGSDFTGDELLLPRHNAAFGGHVYAQAALAVARAWRELEDERGAKQGERLDLHTIHGFFTRRGISDRPFLYTVTPITTSRSFSTLSVTARQPSEPSTNPQGDHFPPADASLPLSPPCFTAICSLKLPEPDSAGVSMQEDPPQTRFAPILSSRKPEDWPPSPPVDITGMVELAGADQAGRFPVATMRKVDMTAYNADRPVHERRELILYKLLRPLPCSSSSGGEGLLWDANAHIVAHAFVADKNGLLMTGNHVGFGYSLARAASLSYSFVVHVNAEQAVMREEDGWWVQEACFPRAAAGRGVVECKIWSPRGVHVATEYQDGLVQGLEMGSSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LY52</accession>
    <name>A0AAJ0LY52_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquinol-cytochrome C chaperone-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_541736</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBP3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717806.1">
        <property type="nucleotide sequence ID" value="XM_062869884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LY52"/>
    <dbReference type="GeneID" id="87888713"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021150">
        <property type="entry name" value="Ubiq_cyt_c_chap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007129">
        <property type="entry name" value="Ubiqinol_cyt_c_chaperone_CPB3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12184">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX ASSEMBLY FACTOR 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12184:SF1">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME-C REDUCTASE COMPLEX ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03981">
        <property type="entry name" value="Ubiq_cyt_C_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquinol-cytochrome c chaperone" evidence="2">
        <location>
            <begin position="156"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3302026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="332" mass="36677" checksum="EB2BF5EB4231D289" modified="2024-07-24" version="1">MACRSCGAGLARLPSRASSPLSRSFLETTPLQLPSPSPSFCYGATSRSASGFVLTYAMIPSLQITAPARTPRRALHTTSSRQKFKLREMLLGRIAQTLATEKSSYYIYGAAERLYNACAAPADYTIDPKDRKAGKLQTTAEGEEIGVSKGGSWHNDLGLLPTFNTWAHITMLHMYLLVVRFRCFDAASQQAWQTYLVNHFFYHAEAKMDEVHELTSRLIRQKYLKDLFVQWRGLMLAYDEGLVKGDAVLASAVWRNLFKAREDVDVRALAAVVAWMRAGLAELGGMTDDEVEVGGHAAFGELTEKFQAVDLPTASMRAVLEQAALKPEASRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZ36</accession>
    <name>A0AAJ0LZ36_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_260634</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3302989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718769.1">
        <property type="nucleotide sequence ID" value="XM_062863323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZ36"/>
    <dbReference type="GeneID" id="87882152"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF232">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="524"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3302989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="579" mass="64768" checksum="BA9D03FBAEB1B1BC" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ0LZH6_9PEZI</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_539834</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719098.1">
        <property type="nucleotide sequence ID" value="XM_062869758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZH6"/>
    <dbReference type="GeneID" id="87888587"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3303318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="333" mass="37670" checksum="73AE91E9B65B6578" modified="2024-07-24" version="1">MRRCTFFSRFCSRPPRTDDGLGEDGEANNEKRVRSPRDWSAIALAVLRSLQFLYVAFAYYSLQDFQRSSYFRDDGPWHHPPDQMRQSWRTLRWVRTQASVILVYHTFIIVIPGLLRLLKPTRRPFTGLSAVFGDGCAMVAMLNIMVQLDTAHEDYCHRPPPRADPITHAMFSFGRNDQHHHHNMDRHRAVCRSLDVVFGLGGIIIVSYLWSALVTAWRAKQSSPPSVHAKVEQVRDVEQGVTPRPAVVMPEAATRPQATSSQRQDSPPPPYRPAVAELAQEPDAGTGYPRGRVSMETVSSVGLDNYLVSDGWRAPEEPPVYSSRPPSLHHAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZM5</accession>
    <name>A0AAJ0LZM5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_486954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719367.1">
        <property type="nucleotide sequence ID" value="XM_062866396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZM5"/>
    <dbReference type="GeneID" id="87885225"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="742"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="343"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="749"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="788"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="815"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="829"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="917"/>
            <end position="926"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3303587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="926" mass="101208" checksum="8CA9E46FB9706089" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZN9</accession>
    <name>A0AAJ0LZN9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquinone biosynthesis O-methyltransferase, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">3-demethylubiquinol 3-O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.64</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">3-demethylubiquinone 3-O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Polyprenyldihydroxybenzoate methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.114</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">COQ3</name>
        <name evidence="7" type="ORF">B0T15DRAFT_401242</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">O-methyltransferase required for two non-consecutive steps during ubiquinone biosynthesis. Catalyzes the 2 O-methylation of 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid into 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid. Also catalyzes the last step of ubiquinone biosynthesis by mediating methylation of 3-demethylubiquinone into ubiquinone. Also able to mediate the methylation of 3-demethylubiquinol into ubiquinol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-methionine = a 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44452"/>
            <dbReference type="Rhea" id="RHEA-COMP:10930"/>
            <dbReference type="Rhea" id="RHEA-COMP:10931"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64694"/>
            <dbReference type="ChEBI" id="CHEBI:84443"/>
            <dbReference type="EC" id="2.1.1.114"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3-demethylubiquinol + S-adenosyl-L-methionine = a ubiquinol + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44380"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="Rhea" id="RHEA-COMP:10914"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:84422"/>
            <dbReference type="EC" id="2.1.1.64"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3-demethylubiquinone + S-adenosyl-L-methionine = a ubiquinone + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:81215"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:19654"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:231825"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion inner membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.64" evidence="5"/>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EC" id="2.1.1.114" evidence="5"/>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0LZN9"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061542">
        <property type="term" value="F:3-demethylubiquinol 3-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010420">
        <property type="term" value="F:polyprenyldihydroxybenzoate methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00472">
        <property type="entry name" value="UbiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010233">
        <property type="entry name" value="UbiG_MeTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01983">
        <property type="entry name" value="UbiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464:SF19">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS O-METHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 5 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 5" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="22"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3303498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="295" mass="32279" checksum="54D1FA7BD8E7A589" modified="2024-07-24" version="1">MRPLLRHAPRLFRPAQSLRRVAAGAAHSTPAAEPCQPSTPYRQLSSTPTLPHTHPASAASSSSSVNETEISHFSALASSWWDPHGPSRPLHLMNPLRHDFIRACLSSSPTSTSTPTALRYLDVGCGGGIFAESAARLPSTLSVTAIDPSPTILAVARSHARRDPALGLSKKLVYLNETIESLPLPESPVGRFDVVSVFEVVEHVDYPAAFLDRVGQFVKPGGWLVLSTIARTWTSWVTTNLVAEDLLGVVPKGTHDWNKYINEGELRRYFDGKGGAWGRRWSWAWCMCPAWGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0LZQ1</accession>
    <name>A0AAJ0LZQ1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_513783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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            <strain evidence="2">CBS 333.67</strain>
        </source>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Cros-Aarteil S."/>
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                <person name="Kuo A."/>
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                <person name="LaButti K."/>
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                <person name="Ament-Velasquez S.L."/>
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                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
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                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 333.67</strain>
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    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Kuo A."/>
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                <person name="LaButti K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 333.67</strain>
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    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
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                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR38119">
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        <source>
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        <source>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
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                <person name="Ament-Velasquez S.L."/>
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                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062867080.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="87885909"/>
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            <end position="152"/>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
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                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
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                <person name="Hiltunen Thoren M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000005">
        <property type="protein sequence ID" value="KAK3304744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_062867081.1"/>
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    <dbReference type="GeneID" id="87885910"/>
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            <begin position="1"/>
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    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3304744.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="561" mass="61311" checksum="6567C55CEC9F1373" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M189</accession>
    <name>A0AAJ0M189_9PEZI</name>
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        <submittedName>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
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                <person name="Cros-Aarteil S."/>
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                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
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                <person name="Ament-Velasquez S.L."/>
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                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
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                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_062864809.1"/>
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        <property type="entry name" value="AGP_Transferase"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
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        <property type="entry name" value="APH"/>
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        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="323"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK3305285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="442" mass="51033" checksum="1692DB29D54E3D65" modified="2024-07-24" version="1">MNDQHREGLEWDDSGWDLVPRWAREPRLEAIAELCRRVLELAAGDHCHVAFYAEGAFNKLYLVESRRGKSLLRVSLPVDPRHKTHGECATLHWIREMTTVPVPKVIAFDDCRDNEIGFEWILMELMPGVSAYKRWRKLSMAEKTQVVEQVAEFQSQLFRHGIEDANFQSIGTLRFGDGTSQLGPGNPKPGRLVSRFFFGGDRFNYDVPRGPFRSSHDWLGTQLGIVREEQSRILETAEDEEDRADAKAILRGAEKLAALLPKIFPQLQNNPLERTVLWHDDLSLANILIGEKDAKITAIIDWEGVSCEPLWVAAEMPKFLRGPSREEEPQRDRYGEANEYDQDDELDNEGKTGLYWIHLMEYDMTQLRKVYAAKMRELWPRWEEEVTYSSLKSDLYEALHRLSDGWQVKRVEKWVDLVIEGGEFPRLSDVLARPADEARTIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M1M2</accession>
    <name>A0AAJ0M1M2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0T15DRAFT_533058</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721451.1">
        <property type="nucleotide sequence ID" value="XM_062869340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M1M2"/>
    <dbReference type="GeneID" id="87888169"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF81">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="49"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="115"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="796"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="883"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="929"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1026"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="129"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="159"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="883"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="894"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="935"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="961"/>
            <end position="973"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3305671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1140" mass="124168" checksum="8603F1D1888A39C2" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M1U5</accession>
    <name>A0AAJ0M1U5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">E3 ubiquitin ligase complex SCF subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_494028</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Controls sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SKP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000004">
        <property type="protein sequence ID" value="KAK3305896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062721676.1">
        <property type="nucleotide sequence ID" value="XM_062866988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M1U5"/>
    <dbReference type="GeneID" id="87885817"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016897">
        <property type="entry name" value="SKP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036296">
        <property type="entry name" value="SKP1-like_dim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016072">
        <property type="entry name" value="Skp1_comp_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11165">
        <property type="entry name" value="SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01466">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028729">
        <property type="entry name" value="E3_ubiquit_lig_SCF_Skp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81382">
        <property type="entry name" value="Skp1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SKP1 component POZ" evidence="7">
        <location>
            <begin position="19"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="SKP1 component dimerisation" evidence="6">
        <location>
            <begin position="145"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00045385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR028729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3305896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="182" mass="20773" checksum="5D4C431F6A84D7E8" modified="2024-07-24" version="1">MAANPTLRLQNMLNPKRRVFEVDRVAAEHSTVIRTILAEFDESYLAGNVIPILVDVCDAALAKVLEWVTRWRDLPKAADVVVDYNQPGRRTTTHAATTRKAEQANEKEMDTTDVMRSPWNKVFFRGVNGEILYEILVIANYLDIKPLCDLCCQLVANMIRDKPIEEVCEILCIDMEFENAFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M297</accession>
    <name>A0AAJ0M297_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_509813</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722216.1">
        <property type="nucleotide sequence ID" value="XM_062867814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M297"/>
    <dbReference type="GeneID" id="87886643"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000009">
        <property type="entry name" value="MFS multidrug transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF51">
        <property type="entry name" value="QUINIDINE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="353"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="436"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="472"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="499"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="76"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3306436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="547" mass="59285" checksum="44BDB22D17AF4896" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M2C1</accession>
    <name>A0AAJ0M2C1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_412668</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722202.1">
        <property type="nucleotide sequence ID" value="XM_062865409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M2C1"/>
    <dbReference type="GeneID" id="87884238"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000106">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF65">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="488"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="523"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3306422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="581" mass="66413" checksum="19E7BBBAB4DB5F40" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M2M1</accession>
    <name>A0AAJ0M2M1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_149230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3306663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722443.1">
        <property type="nucleotide sequence ID" value="XM_062861968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M2M1"/>
    <dbReference type="GeneID" id="87880797"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="307"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3306663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="338" mass="38541" checksum="C3E98794F71E1F3C" modified="2024-07-24" version="1">MDEDDSQTVPVDNTYREVIVHDNREFQRYALENGIYFAPVDDDEIDRLQYMHEIFNMMFDNRLIFPPLPRPRRILDCGYGSGAWAIDVAEQYPECEVIGIDVYPYPVPEALPPNLDFQVDDLNSPSTFPSNYFDLVHSRMMAGGIHADRWMNYLGDTLRILRPGGWCQMVEIYFNAQSDNGTLTSNHALQVWSQSYMQSIQPAKDPRAPLRLQSWMTQAGFVEVESRLLTLPLSGWPTDPRDHAIGTANRPNVHRLLSSLAVFPFAHALNMSNTDIQLLVAQARSEADNPAFKAYFPVYVCIGRKPGSSRHHRQGDSRSHQIPKGARHGDSRKRVRHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M333</accession>
    <name>A0AAJ0M333_9PEZI</name>
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        <recommendedName>
            <fullName evidence="1">Cupin type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_574010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062722938.1">
        <property type="nucleotide sequence ID" value="XM_062870943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M333"/>
    <dbReference type="GeneID" id="87889772"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="1">
        <location>
            <begin position="56"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3307158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="288" mass="32726" checksum="9D62A37FC1A431B6" modified="2024-07-24" version="1">MGFVPITISAGQNPLVQFDGKIKTHFLQPPAGTAFQILQTYQPLAKGDTSGVYRGPPPHFHVHQTERFRVLKGRIGVEINEQAIILRPGDEVAVCPAGNIHRFFLDVDDYVNSEGGGEEDGDWDGESILMVNATDSGKDFVLDRIFLENWYGVRADSFKYYNNKIDFIQQCATFDGGDHYLPFPATLPEWVPKPWSVWIRTLLGYWMTVLIGRWIGGLLGYQPFYREYTTDWELAVAKMQGTWFYRKNVQTAYRAASSWAKLQQMEPWSDEGAARMGLDKANGNLRKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M3A5</accession>
    <name>A0AAJ0M3A5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_510770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723281.1">
        <property type="nucleotide sequence ID" value="XM_062867876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M3A5"/>
    <dbReference type="GeneID" id="87886705"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3307501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="235" mass="26310" checksum="67934710410B745D" modified="2024-07-24" version="1">MPDCDAASPFSPTWRPPRIRARLAESLSKTQGYSQYSLNPLPPGWGRLAFAEEHLVPATTSLWPSIVSFRSTVEAVKSGKCWWLSVGSVMPPHRSSYAGSGRRRRRTAQATMQIDTGFAIVYESAPVVQPVPYLRRCNCGVSRDRHAIIPGVPPKPRSFLDMLPKPDFLRVVGLYHGSNHNIFELESTLEQPQFYGCVRLVYVAEGRTSDVHAYSFESVQSPSESRPQQARDQHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M3N9</accession>
    <name>A0AAJ0M3N9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Utp21 specific WD40 associated putative domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_433228</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000003">
        <property type="protein sequence ID" value="KAK3307579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723359.1">
        <property type="nucleotide sequence ID" value="XM_062865769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M3N9"/>
    <dbReference type="GeneID" id="87884598"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000565">
        <property type="entry name" value="Putative snoRNA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059157">
        <property type="entry name" value="WDR36-Utp21_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007319">
        <property type="entry name" value="WDR36/Utp21_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22840">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22840:SF12">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25171">
        <property type="entry name" value="Beta-prop_WDR36-Utp21_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25168">
        <property type="entry name" value="Beta-prop_WDR36-Utp21_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04192">
        <property type="entry name" value="Utp21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDR36/Utp21 N-terminal" evidence="5">
        <location>
            <begin position="61"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="617"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="702"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="domain" description="WDR36/Utp21 C-terminal" evidence="4">
        <location>
            <begin position="834"/>
            <end position="1043"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3307579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="1047" mass="114805" checksum="1183314DD8460795" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M3P2</accession>
    <name>A0AAJ0M3P2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_85528</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3307803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723583.1">
        <property type="nucleotide sequence ID" value="XM_062871392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M3P2"/>
    <dbReference type="GeneID" id="87890221"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042514416" evidence="3">
        <location>
            <begin position="20"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3307803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="330" mass="34606" checksum="A37A8B412026366E" modified="2024-07-24" version="1">MRALFSLLVQLALLRTCFGKKCYYPNGNEAGIDWACDENAENSPCCAGAPFGFACLENGLCQGKDGKVIRGSCTDETWMSPECPHFCLNWDSVGHDLVPCSNVTGRDTSYCCDEMPNCCDGGVGRFEVPPSNPKTWALLNSESRQYVVVTPRSTTSSSASKTSDASAQPTTDSAEPSTAATSSANTIPAQTASGDSTDNQSQAEPSGQSTGLSTGAQAGIGVGAAVGALLVGAVAYLWWKLNKIKKMAEATGPMPGSYPQPAQGLPMTTYYAGDARHSQKSELPVEPVAHELQGYHPHIQQGEAELAGFPLYSPVATSPSSHTASPHSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M3S7</accession>
    <name>A0AAJ0M3S7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0T15DRAFT_92534</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Tom70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3307985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062723765.1">
        <property type="nucleotide sequence ID" value="XM_062871459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M3S7"/>
    <dbReference type="GeneID" id="87890288"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005687">
        <property type="entry name" value="Tom70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00990">
        <property type="entry name" value="3a0801s09"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46208">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46208:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 10" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="130"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="334"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="402"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="470"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="545"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="59"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3307985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="617" mass="68699" checksum="082F53EF4BEC4ED6" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M421</accession>
    <name>A0AAJ0M421_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_102365</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724017.1">
        <property type="nucleotide sequence ID" value="XM_062861376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M421"/>
    <dbReference type="GeneID" id="87880205"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF12">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_1G14540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3308237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="285" mass="29160" checksum="D97129853D0ABB3D" modified="2024-07-24" version="1">MAEAQLQDFSSLFSLDGKVAVVTGGSRGLGLSAASALLQAGASTVFISSRKAKACETACAALNAQPNLRPGARAIPVPADCATLEGVKQLVAGVSAHGADHVDILLANAGATWGEAFDTHPDGAFAKVMDLNVRGVFNLIREFAPLLQKRASAEDPSRVVITSSVAGLGIGTLGKQATFGYSASKAAVLHLGRNLAVELGPRGITVNSICPGFFPSKMSNGLLAMAGGVEKLAKANPMRRLGRSEDIAGAVVYLTSRAGAHVNGAAIEIDGGAMWQRGQLDVSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M4B1</accession>
    <name>A0AAJ0M4B1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GIY-YIG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0T15DRAFT_109919</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Forms a heterodimer with SLX4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the SLX1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724317.1">
        <property type="nucleotide sequence ID" value="XM_062861489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M4B1"/>
    <dbReference type="GeneID" id="87880318"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033557">
        <property type="term" value="C:Slx1-Slx4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="entry name" value="GIY-YIG endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03100">
        <property type="entry name" value="Endonuc_su_Slx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027520">
        <property type="entry name" value="Slx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048749">
        <property type="entry name" value="SLX1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050381">
        <property type="entry name" value="SLX1_endonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20208">
        <property type="entry name" value="STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20208:SF10">
        <property type="entry name" value="STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21202">
        <property type="entry name" value="SLX1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIY-YIG" evidence="10">
        <location>
            <begin position="10"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3308537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="327" mass="36723" checksum="87E45C203EE6E66A" modified="2024-07-24" version="1">MAVQCKPIPAFYAVYILRSTVRHASLYIGSTPNPPRRLSQHNGLAKGGAARTARRRLRPWEMVGLVSGFPSMTAALKFEWALNNPHLSVHIPSEARITISSQVKRNGQPKKPSKSLSSVMSNLHLLLRVPSFVRWPLTLHFFDRNVFAAWERWCATASEQLRPSLRVVTDFGSGKLPSVAGTERAAAERNGPDDGEEGRAWGIHALPLNYEPIKDYVAKAQETFEFERQGRCIICREDMPSGEGLHVICTNDACDGVGHLACWSRHILKGHEEDSILPIQGQCPKCMGEVHWGLMMKELTLRTRGQKEVETLLKRKCRRATRKDLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M4S8</accession>
    <name>A0AAJ0M4S8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_118892</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3308795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724575.1">
        <property type="nucleotide sequence ID" value="XM_062861600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M4S8"/>
    <dbReference type="GeneID" id="87880429"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3308795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="379" mass="40348" checksum="AC9527BDE8F654DD" modified="2024-07-24" version="1">MPPKEGKSTNFKTYEAQLRLLAAIVASMPQPWKFDFKEIHKLFGESTPDGISWQMRAVKQGANVLKTARDNGEDPVAAFTDHLYKGDGSRGAGTPATPKHRTTSLTKRARSAGKAPASGTTPASKRRKADVKAKEEWEDDEDSPEVDYDELDTTPTKLKPKVLSTPRKFPPLLPHEAWKNPEPGSRPAAKRHVPIAPAPPRPAAPSYNLAPIPGVSSAAGPNVYTNPSDAVGYHYSPQTSMANSPAMDMNATNAMRRGSVVSVSSGNEMFNPFDAASPSASASDANTPQTVASSNAMMMADQQAAAPAQSSSSIKAEDYISPEYAHFASYAANGNGNDNDGGNGSVYGFDFNNQAQDNGHVECGGWQQDAQGYEDAGDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M516</accession>
    <name>A0AAJ0M516_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_128547</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000002">
        <property type="protein sequence ID" value="KAK3309065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062724845.1">
        <property type="nucleotide sequence ID" value="XM_062861720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M516"/>
    <dbReference type="GeneID" id="87880549"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021840">
        <property type="entry name" value="DUF3433"/>
    </dbReference>
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        <property type="entry name" value="SPRAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544">
        <property type="entry name" value="SPRAY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11915">
        <property type="entry name" value="DUF3433"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="480"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="618"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="707"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="785"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="750"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="559"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="579"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="590"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="750"/>
            <end position="759"/>
        </location>
    </feature>
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        <location>
            <begin position="760"/>
            <end position="769"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3309065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="914" mass="99647" checksum="4EC319CC71300E13" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M5I2</accession>
    <name>A0AAJ0M5I2_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_387260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725651.1">
        <property type="nucleotide sequence ID" value="XM_062864371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M5I2"/>
    <dbReference type="GeneID" id="87883200"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF17">
        <property type="entry name" value="ACETYLTRANSFERASE, GNAT FAMILY FAMILY (AFU_ORTHOLOGUE AFUA_8G05690)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="86"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3309871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="271" mass="29709" checksum="97342CDFF957D967" modified="2024-07-24" version="1" fragment="single">PHPGHFYTFSVFRDLKTMATTSRIRVREGTPADVDAIVDIYYKAFRDNVMDQLMYPGGPSEDARRKFTAKVLPRSTPEGEKGESLLCVAEYLPEGSPADGPWEVVAFGKWDLYREARTEEEWKADEFNATADTFGAGCDPSVINAFIGGMTRKQRDHAKGEAALFLGLLACSPARQGLGAGSALMKWGVDLADSLGLPCRLEASPAGYRLYKKFGFEDFDVLDLPVTEKWGVANTKGDNWGQDIAVGLAGRAPDGVHRCALMRRPPKSVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M5R2</accession>
    <name>A0AAJ0M5R2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_17563</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3309904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725684.1">
        <property type="nucleotide sequence ID" value="XM_062862251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M5R2"/>
    <dbReference type="GeneID" id="87881080"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF234">
        <property type="entry name" value="MFS-TYPE TRANSPORTER DBAD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="262"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="354"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="63"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3309904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="454" mass="48494" checksum="7B4CCCA355586B97" modified="2024-07-24" version="1">MEKDADKTYNSESDRTEGDASIRIPDDKTVEAADAEVGNPPARVDPPPSAPNEIPDGGLTAWMQVVGSAAILVNTWGVINTFGVFQAYYETELLKDHPSSDISWIGSLQGGLLFLVGVIAGPLYDSGYFRELLLVGLFLIVFGQFMTSLCTAFWQVMLAQGITMGIGMGLTFLPSAAILGQYFSRHRALALGLASVGSPVAGVIFPVIFDRVRHAAGFGWATRAIAFILLGMSVIPIAFMRMRVPPTGKARALIDTSALRDVPFLLFVAAGLFSFLTLYVGFFYIQLFATSQKTTSESFAPYLVTLLNVGSIFGRVIPNAFADRFGSLNLIIVCIFASAVLAFGWVGITNVGGSVVWVLLYGAFSGGVVSLTPSVIVGLTPDMGRVGARMGVAFVVSGIAILVGTPIAGAILGDQHNPRWLGMILYSAFGMLLATLFYAASRLLLYKHKGTWKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M609</accession>
    <name>A0AAJ0M609_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Peroxidase</fullName>
            <ecNumber evidence="14">1.11.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0T15DRAFT_24852</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 Fe(II)-[cytochrome c] + H2O2 + 2 H(+) = 2 Fe(III)-[cytochrome c] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:16581"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.11.1.5"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Forms a one-to-one complex with cytochrome c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peroxidase family. Cytochrome c peroxidase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="14"/>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062725892.1">
        <property type="nucleotide sequence ID" value="XM_062863140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M609"/>
    <dbReference type="GeneID" id="87881969"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004130">
        <property type="term" value="F:cytochrome-c peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00691">
        <property type="entry name" value="ascorbate_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.420.10:FF:000009">
        <property type="entry name" value="Ascorbate peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.520.10:FF:000005">
        <property type="entry name" value="Cytochrome c peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044831">
        <property type="entry name" value="Ccp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002207">
        <property type="entry name" value="Peroxidase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019793">
        <property type="entry name" value="Peroxidases_heam-ligand_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356:SF58">
        <property type="entry name" value="CYTOCHROME C PEROXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356">
        <property type="entry name" value="THYLAKOID LUMENAL 29 KDA PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00459">
        <property type="entry name" value="ASPEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00435">
        <property type="entry name" value="PEROXIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 14 16" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="15">
        <location>
            <begin position="104"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3310112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="357" mass="39981" checksum="CD7F9CD8B084EE75" modified="2024-07-24" version="1">MATATRTFTRALRTSARPAFTAAPRVAFHQSGRRFYSSEPAAKQGSSAWLWLASAAAVGGGAGWFYLNNQGSATPNVFAPKFEDYQAVYNEIANRLDENSDYDDGSYGPVLLRLAWHASGTYDKETGTGGSNGATMRFAPESDHGANAGLKAARDFLEPVKQKFPWITYSDLWILGGVCAIQEMLGPQIPYRPGRQDKDVAACTPDGRLPDAAQAQDHLRAIFYRMGFNDQEIVALAGAHALGRCHTDRSGYSGPWTFSPTVLTNDYYKLLLDEKWQWKKWNGPKQYEDKKTKSLMMLPADMALIQDKKFKEWVQKYAADNDLFFRDFANVIVKLFELGVPFQPENKERWVFKPVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M6B5</accession>
    <name>A0AAJ0M6B5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_46016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
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                <person name="Powell A.J."/>
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                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
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                <person name="Hiltunen Thoren M."/>
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            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
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                <person name="Cros-Aarteil S."/>
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                <person name="Kuo A."/>
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                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
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                <person name="Ng V."/>
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                <person name="Steindorff A."/>
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                <person name="Labutti K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 333.67</strain>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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            <fullName evidence="6">Pre-rRNA-processing protein IPI3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0T15DRAFT_426688</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the WD repeat IPI3/WDR18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3310939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062726719.1">
        <property type="nucleotide sequence ID" value="XM_062865654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M6Q2"/>
    <dbReference type="GeneID" id="87884483"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120330">
        <property type="term" value="C:rixosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000929">
        <property type="entry name" value="Ribosomal assembly complex component Ipi3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045227">
        <property type="entry name" value="WDR18/Ipi3/RID3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763">
        <property type="entry name" value="WD-REPEAT PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 5 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="171"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3310939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="440" mass="47486" checksum="59F7F33EA4FC0AE9" modified="2024-07-24" version="1">MLSEEFVSAICGPPLSSNTAIAKDVGIYCHTLSPTYSVKSTFKKSSAPVNCLAVSETHVFAAQHEKAYVHVYSRLRGNQEAFVAFPERIRCLTLAGDVLVMGTTEGRLMLWETCTGRLVSTPARHVQAVSCVVATPFHVLTGSDDSDIHVWSLPQLLELDSAAEHEPQRSLSNHRTAITGLSVSPSVSSDTNFCVSASKDRSCIIWNYQTGDALRTVLFPSSPLCLALDPSSRAVCVSCEDGSLYLTELFAGKPLLGPGSEDAATVVQISSPFGATQPDVGPASCLSLSYDGTMLLTGHPRGQIMRWDIAENKSPVELANLNAAVTNVAFVSPFPANKPTKTVTITKPSQAERAYTFTGQFETYAATGTRFDSLLNATGFPQEAMEDAIAAFYQPAAAAAESAGDQELQRQNDELWEIINEQRALQKHTFQRYVEAKSSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0M7D3</accession>
    <name>A0AAJ0M7D3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B0T15DRAFT_521873</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="JAUDZG010000001">
        <property type="protein sequence ID" value="KAK3311567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062727347.1">
        <property type="nucleotide sequence ID" value="XM_062868584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0M7D3"/>
    <dbReference type="GeneID" id="87887413"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF9">
        <property type="entry name" value="ENDOGLUCANASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042478010" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="16">
        <location>
            <begin position="20"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="17">
        <location>
            <begin position="298"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK3311567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="338" mass="33746" checksum="9FFA33CA126DA6A9" modified="2024-07-24" version="1">MRSTFTAALAALAAQQAAGHATFQQLWVDGTDYGTSCVRLPSSNSPVTNVGSRDFACNAGTRPVSGKCPVRAGGTVTVEMHQQPGDRSCNNEAIGGAHWGPVQVYLSKVPDASTADGASVGWFKIFSDSWAKKAGGAVGDDDHWGTRDLNACCGKMDVKIPADLAPGDYLLRAEALALHTAGQSGGAQFYMSCYQITVSGGSGGTSTPATVRFPGAYSANDPGIKINIHAAVSNYVAPGPAVYSGGTTKKAGSGCAGCENTCKVGSSPTAVAPSSGNGAANGGGATPGQGTGSGAGACSVQAYGQCGGSGYSGCTQCASGYTCKDVSPPHYSQCVPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GKT6</accession>
    <name>A0AAJ0GKT6_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_323202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717559.1">
        <property type="nucleotide sequence ID" value="XM_062864074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GKT6"/>
    <dbReference type="GeneID" id="87882903"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3301779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="316" mass="35647" checksum="82DE9CEB23D27E27" modified="2024-07-24" version="1">MLTEAGLDHPMFKDKVWLHQPCWSRNFHFRLVPISTLLATVVKPRRGIWSGCGLQVRSARHSIVRAVFWPGGLSMLFAGASWACVGKPDLARSDTRLRMRQRLSEFDPRPERPLPCGRSLSWDISLAIAALHSNAPLEIHTARYRRRLDRPKASSPDSWCQGQPTPHPGEGTRPANVIITCGWRFMTYEEAVLCAFAAERIGTTCAATPMGEREEPPASRRPPRRHRKLRRVSGAGSRMRADGLHGVNHDNWVETMSCFNRRHVKPNKRPRGVDVWDLASCKQMVEVDIEVEPGKETLSSGPRCGVAQSRRPRLCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GKU0</accession>
    <name>A0AAJ0GKU0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_323215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717558.1">
        <property type="nucleotide sequence ID" value="XM_062864075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GKU0"/>
    <dbReference type="GeneID" id="87882904"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3301778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="379" mass="39267" checksum="9F60231227CA0EDA" modified="2024-07-24" version="1">MMSSAMQMAGQHVPYIPTSDTMNRHEYGITKNRKTAASTGGGRAWSEDEEAYLLQTRLQKMPYKHIAAHLKKTELACRLHYHQLSHGSNRRKRTTSMSSGSSASGHSPVLHTSIPSPIHEHGGAPSRSVSPPESAGSYDSRSPGGIQLPSIMSAAASTNTSPRLPTILPKPASMTLALASSLGASGSTNTASPTAPRGYPAPFYGAASGSAPLPAARGSNGSAHQHGPGRLRLDCSALPPAPSAGGLPAPPGFMASHPVDMARLTAVYNAHRASFWAAVAADYGPGANPLVLEQAWRGTAPGNTPSSSSGLVGIAAHTPITPVGSPEDQVYGAAQGSHPKPDKTRISAILGIEADPRSPSEREMVRRLEEDRGVGVVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GKU3</accession>
    <name>A0AAJ0GKU3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Clr5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0T15DRAFT_323067</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717556.1">
        <property type="nucleotide sequence ID" value="XM_062864072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GKU3"/>
    <dbReference type="GeneID" id="87882901"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025676">
        <property type="entry name" value="Clr5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173">
        <property type="entry name" value="ANKYRIN REPEAT CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173:SF74">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14420">
        <property type="entry name" value="Clr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clr5" evidence="5">
        <location>
            <begin position="10"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="320"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="353"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="461"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="494"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="112"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3301776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="632" mass="70188" checksum="92B37F5A7BEFCF22" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GKX5</accession>
    <name>A0AAJ0GKX5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_324670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000008">
        <property type="protein sequence ID" value="KAK3301826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717606.1">
        <property type="nucleotide sequence ID" value="XM_062864091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GKX5"/>
    <dbReference type="GeneID" id="87882920"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="21"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3301826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="240" mass="27280" checksum="04BDDE1450A495CD" modified="2024-07-24" version="1">MTSPADPHTKCYSHNNGNAADLLDRLAVSELCKGWPVYRDASEWKNYRSLFTDDALVWTTWSGPRPVDEFIAISKAGKEKGVFIMHRECGTLVELSQQNRRAIGKMKATITHRFTFDPATGGRGAVSATETAEFDVDCDCRFIFFCEKNDANEWKTKYVKLFYEKDKVVPVDGYTAPRFTVEELSPIPRGYKYLGAAQARLGYEIDLELPTASGALWDRMYGEMEKWLDGQAVDLCWEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GLC0</accession>
    <name>A0AAJ0GLC0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Intradiol ring-cleavage dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_289343</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the intradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062717803.1">
        <property type="nucleotide sequence ID" value="XM_062863689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GLC0"/>
    <dbReference type="GeneID" id="87882518"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018576">
        <property type="term" value="F:catechol 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009712">
        <property type="term" value="P:catechol-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03461">
        <property type="entry name" value="1_2-HQD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039390">
        <property type="entry name" value="1_2-HQD/HQD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007535">
        <property type="entry name" value="Catechol_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050770">
        <property type="entry name" value="Intradiol_RC_Dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711">
        <property type="entry name" value="DIOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711:SF7">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASES DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04444">
        <property type="entry name" value="Dioxygenase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00083">
        <property type="entry name" value="INTRADIOL_DIOXYGENAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Intradiol ring-cleavage dioxygenases" evidence="8">
        <location>
            <begin position="164"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3302023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="313" mass="34715" checksum="D04EEC53A40E47AF" modified="2024-07-24" version="1">MGQMIPDHASRAPVDPKPNDTSKKPKYDPAFTDKVIAATGPNANRRLAEVMPSLVRHLHAFAREVNLTVEEWTAAVEFINECGQMSDDRRNETQLLCDIVGLESLVGEITSKLVSTSESETPSAVLGPFYRQDAPLLPHGSSIIKDLGPSVPWYEQAVADSAFVTGRVLSNSGEPIQGAILDVWHAAPNGLYEQQDESQPDMNFRGRFETDASGRYAFYALRPVPYPIPDDGPAGRLLALLDRHPYRPGHIHFIVTAPGFRPLTTQLYDDRDQYLGKDSVFAVKDELVVRFAPREGDPNARWSLQYDFVLGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GLM8</accession>
    <name>A0AAJ0GLM8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Calpain catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0T15DRAFT_297498</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family. PalB/RIM13 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718008.1">
        <property type="nucleotide sequence ID" value="XM_062863775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GLM8"/>
    <dbReference type="GeneID" id="87882604"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022683">
        <property type="entry name" value="Calpain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036213">
        <property type="entry name" value="Calpain_III_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051297">
        <property type="entry name" value="PalB/RIM13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46143">
        <property type="entry name" value="CALPAIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46143:SF1">
        <property type="entry name" value="CALPAIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25435">
        <property type="entry name" value="PalB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00720">
        <property type="entry name" value="calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49758">
        <property type="entry name" value="Calpain large subunit, middle domain (domain III)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="8">
        <location>
            <begin position="71"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="619"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="634"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR622684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3302228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="890" mass="96113" checksum="48D4C1DF258929EA" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GLQ5</accession>
    <name>A0AAJ0GLQ5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0T15DRAFT_404179</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718007.1">
        <property type="nucleotide sequence ID" value="XM_062865240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GLQ5"/>
    <dbReference type="GeneID" id="87884069"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015217">
        <property type="term" value="F:ADP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052217">
        <property type="entry name" value="Mito/Peroxisomal_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939:SF1">
        <property type="entry name" value="MITOCHONDRIAL THIAMINE PYROPHOSPHATE CARRIER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="10"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="119"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="212"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3302227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="337" mass="36481" checksum="CE5D4727766AF1B8" modified="2024-07-24" version="1">MAVQSKPAPIGPWGKATAGAAGAVLANALVYPLDLVKTKLQVQVKLSDAEKADSNPNEAHYKSTWDAITRIASSEGVTGLYAGMGGSLLGVASTNFAYFYWYSVVRTLYFKYAKAVAQPSTVVELSLGAVAGALAQLFTIPVAVITTRQQTQSKEERKGFIETAREVIEGEDGVCGLWRGLKASLVLVINPSITYGAYERLKEVLFPGKKNLSPWEAFALGAMSKALATIVTQPLIVAKVGLQSKPPPARQGKPFKSFVEVMQFIIQNEGPLSLFKGIGPQILKGLLVQGILMMTKERVELMFVLFVRYLQVVRSRQLQRTTNLADAAKLVTPMTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GMD2</accession>
    <name>A0AAJ0GMD2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chaperonin Cpn60/TCP-1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0T15DRAFT_487539</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718145.1">
        <property type="nucleotide sequence ID" value="XM_062866444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GMD2"/>
    <dbReference type="GeneID" id="87885273"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03341">
        <property type="entry name" value="TCP1_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000008">
        <property type="entry name" value="T-complex protein 1 subunit theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012721">
        <property type="entry name" value="Chap_CCT_theta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02346">
        <property type="entry name" value="chap_CCT_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3302365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="547" mass="59381" checksum="334E4F1DC34C66D7" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GMK2</accession>
    <name>A0AAJ0GMK2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_313054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000007">
        <property type="protein sequence ID" value="KAK3302707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718487.1">
        <property type="nucleotide sequence ID" value="XM_062863954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GMK2"/>
    <dbReference type="GeneID" id="87882783"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3302707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="228" mass="25182" checksum="EA5EDA02748B93B6" modified="2024-07-24" version="1">MNFLRKLVGRPEDANKPPTDANDQPQSTFITPDPFASPAQFQAVKEHIQALARRDPARFAALRRMAAFQGSLAWLEANFPDESKHEIIVPGPFPDAFPGPLNGPGLEHIQPGDTRIFFMRRKDVSGPAGIVLMQLTVFPGTEVTGEDGESVMWLGTPAMETAVAAFLGLLRRMVDSGNLEKCTAIIAMGVDMTIYHFTPERGFFDPPEGFGFRQEKLDWDQEGILPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GMU5</accession>
    <name>A0AAJ0GMU5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0T15DRAFT_495475</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3302901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718681.1">
        <property type="nucleotide sequence ID" value="XM_062867102.1"/>
    </dbReference>
    <dbReference type="GeneID" id="87885931"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000209">
        <property type="entry name" value="Polyketide synthase Pks12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056501">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF29">
        <property type="entry name" value="ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23297">
        <property type="entry name" value="ACP_SdgA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23114">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="10">
        <location>
            <begin position="46"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="11">
        <location>
            <begin position="1010"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="2650"/>
            <end position="2727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="7">
        <location>
            <begin position="1010"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="7">
        <location>
            <begin position="1169"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1745"/>
            <end position="1768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2612"/>
            <end position="2638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1756"/>
            <end position="1767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="2612"/>
            <end position="2623"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="7">
        <location>
            <position position="1042"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="7">
        <location>
            <position position="1235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3302901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="2731" mass="295043" checksum="CD93BF117AD0AA4A" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GN32</accession>
    <name>A0AAJ0GN32_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase family 55 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0T15DRAFT_559472</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3302964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718744.1">
        <property type="nucleotide sequence ID" value="XM_062870509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GN32"/>
    <dbReference type="GeneID" id="87889338"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23668">
        <property type="entry name" value="GH55_beta13glucanase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000049">
        <property type="entry name" value="Putative exo-beta-1,3-glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039279">
        <property type="entry name" value="QRT3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="RHGA/B-epi-like_pectate_lyase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928:SF2">
        <property type="entry name" value="PECTATE LYASE SUPERFAMILY PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928">
        <property type="entry name" value="POLYGALACTURONASE QRT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pect-lyase_RHGA_epim"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042589265" evidence="1">
        <location>
            <begin position="22"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="2">
        <location>
            <begin position="91"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="2">
        <location>
            <begin position="419"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3302964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="775" mass="82751" checksum="7B93F745851B9285" modified="2024-07-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GN58</accession>
    <name>A0AAJ0GN58_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Isochorismatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0T15DRAFT_559724</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062718822.1">
        <property type="nucleotide sequence ID" value="XM_062870517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GN58"/>
    <dbReference type="GeneID" id="87889346"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050272">
        <property type="entry name" value="Isochorismatase-like_hydrls"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540:SF6">
        <property type="entry name" value="ISOCHORISMATASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540">
        <property type="entry name" value="PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="5"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3303042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="212" mass="23351" checksum="A9A3855A1AF2BC90" modified="2024-07-24" version="1">MTTKTALFVIDIQNDLTTDPKTRIPHADRIRTAGTKILSVARARLDKNSPSSTHHTDVPPPALIVFVQHEERPEDGPLVRGSEAWKLVFEPRADAPYYERLVGKYTRDTFQSNPSLASELKEQHGIQQIVAFGIQSECCVEATCAGALAAGFGVTLLSGAHSTYDDVPQGPDGSVSKTAVEIEREVEERLKRKGARVVAWEDVVAEWERDVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GNN2</accession>
    <name>A0AAJ0GNN2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0T15DRAFT_539664</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719046.1">
        <property type="nucleotide sequence ID" value="XM_062869748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GNN2"/>
    <dbReference type="GeneID" id="87888577"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3303266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <sequence length="87" mass="9962" checksum="26F5C0C676BCBC87" modified="2024-07-24" version="1">MCFNLVVVTCVVVDWFSCINYSRPVPHLSHSFRRMRLCIVVMQSRSQEPSSAPPLNSTTWLLKMTRKQAGTGMHIPLVADRYQSRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GNW6</accession>
    <name>A0AAJ0GNW6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0T15DRAFT_495986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719214.1">
        <property type="nucleotide sequence ID" value="XM_062867142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GNW6"/>
    <dbReference type="GeneID" id="87885971"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13214">
        <property type="entry name" value="PH-GRAM_WBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044852">
        <property type="entry name" value="WBP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31606">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 2, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31606:SF1">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 2, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="190"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3303434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001273166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="260" mass="28857" checksum="17E0CA43990DF024" modified="2024-07-24" version="1">MADQFLAEQHTWTLFRHSQSDEEDSWVMLTRDGQIVPIPGEKILHTSRPRVSLEISTPRELQIAEPFSLKCDNGIAYITNERVIYLPARPSEDFKSFFTPVLNFSDTHVHSSWIGPWSWGGTVRPVPGGGIPMHIPRIDVKFAFRDGGHSDFQTKFEWLKERLHHAQELGLIPGQNLEPPPPYEVGTQGPSPSSSSSSSSAAAAAAAAAPGDGHAQASTQTQQQPPQPAPDEPPPDYVEAQTQAVAMRYEERMREEAERQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ0GPD0</accession>
    <name>A0AAJ0GPD0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0T15DRAFT_496179</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Chaetomium strumarium</name>
        <dbReference type="NCBI Taxonomy" id="1170767"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Chaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Mondo S.J."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Labutti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 333.67</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAUDZG010000006">
        <property type="protein sequence ID" value="KAK3303641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_062719421.1">
        <property type="nucleotide sequence ID" value="XM_062867164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ0GPD0"/>
    <dbReference type="GeneID" id="87885993"/>
    <dbReference type="Proteomes" id="UP001273166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050745">
        <property type="entry name" value="Multifunctional_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189:SF50">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="288"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="409"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="366"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="498"